@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00760: (2016-06-02 )
MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLDWHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFVAQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREIGNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDIGLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKEIKNMIHEKGGRAWRSTQ
Atome Classification :
(20 SA)
---.........10----........20........30.....-.----.-----.----40----.........50........60........70........--80..---------......90...---....-.100-........110.......120.-......130..----..-----.---.--.-140--.....-.-.-.-------------150.......160........170.......180.......190.......200.......210.......220.......230.......240.......250..-....-.-260.-.......270.......280.......290.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---
M
I
Y
VN
G
R
Y
MEE----KDAVLSPFDHG
F
L
Y
G
I
G
V
F
E
T
F
R
L
Y-E----G-----C----P-----
F
L
L
D
W
H
I
E
R
L
E
R
A
L
KD
L
Q
I
E
Y
TV
S
K
H
E
I
L
E
M
L
D
K
L
L
K
LN--DIKD---------GN
A
R
V
R
L
N
I
SA---GISD-KG-
F
-
V
A
QTYDK
P
T
V
L
C
F
VNQLKPESL-PLQKE
G
K
V
L
S
I
----RR-----N---T--P-E-G--
S
F
R
L
K-
S
-
H
-
H
-------------
Y
L
N
N
M
Y
A
K
REIG-NDPR
V
E
G
I
F
LTEDG
A
V
A
E
G
I
I
S
N
V
F
WRKG
R
C
I
YTPSL
D
T
G
I
L
D
G
V
T
R
R
F
I
IENAKDI
G
L
E
L
KTG
R
Y
E
L
E
A
LLTA
D
E
A
WMTN
S
V
L
E
IIPFT
K
I
E
-
E
VNY-G-S-QS-G
E
A
T
S
A
L
Q
L
L
Y
K
K
E
I
K
N
M
I
H
E
KGGRAWRSTQ
27
HHSearch
88.90
26%
-95
- C5 -
3U0G
3
?
A:
[30-320]
---
K
I
W
M
D
G
K
L
I
E
W
----
R
D
A
K
I
H
V
L
T
H
T
L
H
Y
G
M
G
V
F
E
G
V
R
A
Y
-
K
----
T
ADG
G
T
A
----
I
-----
F
R
L
K
E
H
T
K
R
L
L
N
S
A
K
I
F
Q
M
D
V
P
F
D
Q
E
T
L
E
A
A
Q
R
D
V
V
R
E
N
--
K
L
-----------
E
S
C
Y
L
R
P
I
I
W
I
---
G
S
E
K
-
L
G
-
V
-
S
A
K
G
-
N
T
I
H
V
A
I
A
A
W
P
W
G
----
E
E
G
L
A
K
G
I
R
V
K
T
----
S
S
F----
T
RHH
V
--
N
-
V
-
S
--
M
V
R
A
K
-
A
-
S
G
W
-------------
Y
V
N
S
I
L
A
N
Q
E
A
T
A
D
G
Y
-
D
E
A
L
L
L
D
V
D
G
Y
V
S
E
G
S
G
E
N
F
F
L
V
N
R
G
K
L
Y
T
P
D
L
A
-
S
C
L
D
G
I
T
R
D
T
V
I
T
L
A
K
E
A
G
I
E
V
I
E
K
R
I
T
R
D
E
V
Y
T
A
D
E
A
F
F
T
G
T
A
A
E
V
T
P
I
R
E
L
D
-
N
R
T
I
-
G
G
G
-
A
R
-
G
P
I
T
E
K
L
Q
S
A
F
F
D
V
V
N
G
K
S
A
K
----------
33
HHSearch
87.52
25%
-92
- C5 -
5CE8
1
?
A:
[15-299]
----
V
W
L
D
G
R
L
V
D
E
----
E
E
A
K
V
T
V
L
S
P
S
L
N
Y
G
F
G
V
F
E
G
I
R
A
Y
W
N
----
G
E
N
L
--
Y
----
V
-----
F
R
L
R
D
H
M
E
R
L
L
R
S
A
K
I
I
G
L
D
V
P
Y
T
A
E
E
L
S
K
A
V
V
E
T
V
R
A
N
--
G
F
-
K
---------
E
D
L
Y
I
R
P
V
A
Y
I
---
S
K
P
Q
-
I
S
-
L
-
D
V
R
G
-
L
Q
A
S
V
A
I
A
A
I
P
F
G
K
Y
----
L
K
V
E
G
V
R
A
A
V
----
V
S
W----
R
RV-
H
--
T
S
M
-
M
--
P
V
M
A
K
-
A
-
T
G
I
-------------
Y
L
N
S
I
M
A
A
V
E
A
R
A
R
G
Y
-
D
E
A
I
M
L
N
A
E
G
K
V
V
E
G
S
G
E
N
I
F
I
V
R
R
G
V
L
M
T
P
P
L
E
D
G
I
L
E
G
I
T
R
E
T
V
I
S
I
A
G
D
L
G
I
P
L
L
E
K
S
I
T
R
E
E
L
Y
A
A
D
E
A
F
F
V
G
T
A
A
E
I
T
P
I
I
E
I
D
-
G
R
V
L
-
Q
----
R
-
G
P
I
T
Q
K
I
A
E
T
Y
R
R
I
V
L
G
K
E
E
K
Y
---------
23
HHSearch
86.98
26%
-97
- C5 -
2EIY
5
?
A:
[7-296]
---
L
I
W
M
N
G
A
F
V
P
Q
----
E
E
A
K
T
S
V
L
S
H
A
L
H
Y
G
T
S
V
F
E
G
I
R
A
Y
-
E
----
T
AK
G
P
-
A
----
I
-----
F
R
L
K
E
H
V
K
R
F
Y
N
S
A
K
V
L
R
M
E
I
P
F
A
P
E
E
L
E
E
A
I
K
E
V
V
R
R
N
--
G
Y
-----------
R
S
C
Y
I
R
P
L
A
W
M
---
G
A
K
A
-
L
G
-
V
-
N
P
L
P
N
N
P
A
E
V
M
V
A
A
W
E
W
--------
V
R
K
G
A
R
L
I
T
----
S
S
W----
A
RFP
A
--
N
-
V
-
M
--
P
G
K
A
K
-
V
G
G
-
N
-------------
Y
V
N
S
A
L
A
K
M
E
A
V
A
A
G
A
-
D
E
A
L
L
L
D
E
E
G
Y
V
A
E
G
S
G
E
N
L
F
F
V
R
D
G
V
I
Y
A
L
E
H
S
-
V
N
L
E
G
I
T
R
D
S
V
I
R
I
A
K
D
L
G
Y
E
V
Q
V
V
R
A
T
R
D
Q
L
Y
M
A
D
E
V
F
M
T
G
T
A
A
E
V
T
P
V
S
M
I
D
-
W
R
P
I
-
G
K
G
-
T
A
-
G
P
V
A
L
R
L
R
E
V
Y
L
E
A
V
T
G
R
R
P
-----------
43
Fugue
84.62
25%
-86
- C5 -
1A3G
1
ILVE_ECOLI
A:
[4-308]
KAD
Y
I
W
F
N
G
E
M
V
R
W
----
E
D
A
K
V
H
V
M
S
H
A
L
H
Y
G
T
S
V
F
E
G
I
R
C
Y
-
D
SHKG
P
-----
V
----
V
-----
F
R
H
R
E
H
M
Q
R
L
H
D
S
A
K
I
Y
R
F
P
V
S
Q
S
I
D
E
L
M
E
A
C
R
D
V
I
R
K
N
--
N
L
T
S
-----------
A
Y
I
R
P
L
I
F
V
---
G
D
V
G
-
M
G
-
V
-
N
P
P
A
G
-
Y
S
T
D
V
I
I
A
A
F
P
W
---------
Q
G
I
D
A
M
V
S
SWN
R
A
-----
A
---
P
--
N
-
T
-
I
--
P
T
A
A
K
A
G
-
G
-
N
-------------
Y
L
S
S
L
L
V
G
S
E
A
R
-
R
H
G
Y
Q
E
G
I
A
L
D
V
N
G
Y
I
S
E
G
A
G
E
N
L
F
E
V
K
D
G
V
L
F
T
P
P
F
T
S
S
A
L
P
G
I
T
R
D
A
I
I
K
L
A
K
E
L
G
I
E
V
R
E
Q
V
L
S
R
E
S
L
Y
L
A
D
E
V
F
M
S
G
T
A
A
E
I
T
P
V
R
S
V
D
-
G
I
Q
V
-
G
-
E
G
R
C
-
G
P
V
T
K
R
I
Q
Q
A
F
F
G
L
F
T
G
E
T
E
D
K
W
G
W
L
D
Q
V
N
Q
22
HHSearch
82.33
25%
-88
* C5 *
1IYE
1
ILVE_ECOLI
A:
[8-298]
---
Y
I
W
F
N
G
E
M
V
R
W
----
E
D
A
K
V
H
V
M
S
H
A
L
H
Y
G
T
S
V
F
E
G
I
R
C
Y
-
D
----
S
-----
H
K
G
P
V
V
-----
F
R
H
R
E
H
M
Q
R
L
H
D
S
A
K
I
Y
R
F
P
V
S
Q
S
I
D
E
L
M
E
A
C
R
D
V
I
R
K
N
--
N
L
-----------
T
S
A
Y
I
R
P
L
I
F
V
---
G
D
V
G
-
M
G
-
V
-
N
P
P
A
G
Y
S
T
D
V
I
I
A
A
F
P
W
G
A
Y
L
G
A
E
A
L
E
Q
G
I
D
A
M
V
----
S
S
W----
N
---
R
AA
P
-
N
T
I
--
P
T
A
A
K
-
A
G
G
-
N
-------------
Y
L
S
S
L
L
V
G
S
E
A
R
R
H
G
Y
-
Q
E
G
I
A
L
D
V
N
G
Y
I
S
E
G
A
G
E
N
L
F
E
V
K
D
G
V
L
F
T
P
P
F
T
S
S
A
L
P
G
I
T
R
D
A
I
I
K
L
A
K
E
L
G
I
E
V
R
E
Q
V
L
S
R
E
S
L
Y
L
A
D
E
V
F
M
S
G
T
A
A
E
I
T
P
V
R
S
V
D
-
G
I
Q
V
-
G
E
G
-
R
C
-
G
P
V
T
K
R
I
Q
Q
A
F
F
G
L
F
T
G
E
T
E
-----------
30
HHSearch
81.94
27%
-87
- C5 -
2Y4R
15
?
A:
[23-290]
---
L
D
W
V
D
G
R
P
--------
A
A
E
L
S
V
R
D
R
G
L
A
Y
G
D
G
L
F
E
T
L
A
V
R
-
A
----
G
-----
T
----
P
-----
R
L
L
E
R
H
L
A
R
L
E
E
G
C
R
R
L
A
I
P
L
D
--
T
A
A
L
R
Q
E
L
L
A
F
C
A
A
L
---------------
G
D
G
V
A
K
L
I
V
T
R
---
G
E
G
L
-
R
G
-
Y
-
A
P
P
A
E
A
S
P
R
R
I
L
S
G
S
P
R
P
A
Y
P
E
-
R
H
W
Q
Q
G
V
R
L
F
A
----
C
R
T
R
L
--
A
---
E
--
Q
-
P
-
L
--
L
A
G
L
K
-
H
-
L
-
N
-------------
R
L
E
Q
V
L
A
R
A
E
W
S
D
A
G
H
-
A
E
G
L
M
L
D
V
H
E
R
V
V
E
G
V
F
S
N
L
L
L
V
L
D
G
T
L
V
A
P
D
L
R
R
C
G
V
A
G
V
M
R
A
E
L
L
E
R
A
E
G
I
G
V
P
L
A
I
R
D
V
S
M
A
E
L
A
T
A
D
E
V
F
L
C
N
S
Q
F
G
I
W
P
V
R
A
L
D
-
E
H
V
W
-
P
----
V
-
G
E
L
T
R
K
L
Q
D
Q
L
R
D
D
L
----------------
14
PsiBlast_PDB
81.50
26%
-92
- C5 -
3U0G
3
?
A:
[31-310]
----
I
W
M
D
G
K
L
I
E
W
----
R
D
A
K
I
H
V
L
T
H
T
L
H
Y
G
M
G
V
F
E
G
V
R
A
Y
-
K
----
T
-----
A
----
D
G
G
T
A
I
F
R
L
K
E
H
T
K
R
L
L
N
S
A
K
I
F
Q
M
D
V
P
F
D
Q
E
T
L
E
A
A
Q
R
D
V
V
R
E
N
--
K
L
E
S
---------
C
Y
L
R
P
I
I
W
I
G
S
EKL
G
V
S
A
-
K
G
-----------
N
T
I
H
V
A
I
A
A
W
P
W
G
-----
E
E
G
L
A
K
G
I
----
R
V
-----
K
---
T
--
S
-
S
-------
F
T
-
R
-
H
-
H
VNVSMVRAKASGW
Y
V
N
S
I
L
A
N
Q
E
A
T
-
A
D
G
Y
D
E
A
L
L
L
D
V
D
G
Y
V
S
E
G
S
G
E
N
F
F
L
V
N
R
G
K
L
Y
T
P
D
L
A
S
-
C
L
D
G
I
T
R
D
T
V
I
T
L
A
K
E
A
G
I
E
V
I
E
K
R
I
T
R
D
E
V
Y
T
A
D
E
A
F
F
T
G
T
A
A
E
V
T
P
I
R
E
L
D
-
N
R
T
I
-
G
-
G
-
G
A
R
G
P
I
T
E
K
L
Q
S
A
F
--------------------
34
HHSearch
81.21
25%
-98
- C5 -
3CSW
6
ILVE_THEMA
A:
[14-281]
---
L
I
W
W
R
G
K
F
R
R
A
----
D
E
I
S
L
D
F
S
L
F
E
K
S
L
Q
G
A
V
Y
E
T
L
R
T
Y
-
S
----
R
-----
A
----
P
-----
F
A
A
Y
K
H
Y
T
R
L
K
R
S
A
D
F
F
N
L
P
L
S
L
S
F
D
E
F
T
K
V
L
K
A
G
A
D
E
F
--
K
------------
Q
E
V
R
I
K
V
Y
L
F
P
---
D
S
G
E
---------------
V
L
F
V
F
S
P
L
N
I
P
----
D
L
E
T
G
V
E
V
K
I
----
S
N
VRRI-
P
---
D
--
L
-
S
-
T
--
P
P
A
L
K
-
I
-
T
-
G
-------------
R
T
D
I
V
L
A
R
R
E
I
--
V
D
C
-
Y
D
V
I
L
L
G
L
N
G
Q
V
C
E
G
S
F
S
N
V
F
L
V
K
E
G
K
L
I
T
P
S
L
D
S
G
I
L
D
G
I
T
R
E
N
V
I
K
L
A
K
S
L
E
I
P
V
E
E
R
V
V
W
V
W
E
L
F
E
A
D
E
M
F
L
T
H
T
S
A
G
V
V
P
V
R
R
L
N
-
E
H
S
F
-
F
E
E
-
E
P
-
G
P
V
T
A
T
L
M
E
N
F
E
P
F
V
L
N
L
E
E
N
----------
6
PsiBlast_PDB
80.74
25%
-91
- C5 -
1I1K
1
ILVE_ECOLI
A:
[9-289]
----
I
W
F
N
G
E
M
V
R
W
----
E
D
A
K
V
H
V
M
S
H
A
L
H
Y
G
T
S
V
F
E
G
I
R
C
Y
-
D
----
S
HK
G
P
-
V
----
V
-----
F
R
H
R
E
H
M
Q
R
L
H
D
S
A
K
I
Y
R
F
P
V
S
Q
S
I
D
E
L
M
E
A
C
R
D
V
I
R
K
N
--
N
L
T
S
A
Y
I
R
P
L
I
F
V
G
D
V
G
M
G
V
N
P
P
A
---
G
Y
S
T
-
D
V
-
I
-
I
A
-------
A
F
P
W
-------
A
L
-
E
Q
G
I
D
A
M
V
S
S
W
----
N
R
-----
A
---
A
--
P
-
N
-
T
IP
T
A
A
K
A
-
G
-
G
-
N
-------------
Y
L
S
S
L
L
V
G
S
E
A
R
-
R
H
G
Y
Q
E
G
I
A
L
D
V
N
G
Y
I
S
E
G
A
G
E
N
L
F
E
V
K
D
G
V
L
F
T
P
P
F
T
S
S
A
L
P
G
I
T
R
D
A
I
I
K
L
A
K
E
L
G
I
E
V
R
E
Q
V
L
S
R
E
S
L
Y
L
A
D
E
V
F
M
S
G
T
A
A
E
I
T
P
V
R
S
V
D
-
G
I
Q
V
-
G
E
G
-
R
C
-
G
P
V
T
K
R
I
Q
Q
A
F
--------------------
12
PsiBlast_PDB
80.54
25%
-110
- C5 -
4PBC
2
?
A:
[17-301]
---
I
V
Y
L
S
V
S
A
Q
E
E
L
V
P
L
S
E
A
R
V
P
V
L
D
R
G
F
I
F
G
D
G
V
Y
E
V
V
P
V
Y
-
A
----
H
DG
A
H
-
V
----
P
-----
F
R
I
E
Q
H
L
D
R
L
A
R
S
L
K
K
I
G
I
D
N
P
H
D
A
A
G
W
R
A
L
I
E
R
V
V
A
A
N
A
E
G
L
G
D
---------
G
N
A
L
V
Y
L
Q
V
T
R
---
G
V
A
K
-
R
G
-
H
-
A
F
P
A
N
A
V
P
T
V
F
A
M
T
S
P
L
R
---
L
-
P
S
E
E
E
-
R
A
K
G
V
----
R
C
-----
V
---
T
--
A
-
E
-
D
R--
C
D
I
K
-
S
-
I
-
S
-------------
L
L
G
N
V
L
M
A
Q
H
A
A
-
E
R
D
A
F
E
T
I
Q
L
R
D
E
N
-
V
T
E
G
S
S
S
N
V
W
I
V
K
N
G
E
L
F
A
P
P
R
--------
R
Y
A
L
V
E
Q
L
A
D
E
C
G
I
R
F
V
A
R
E
I
S
E
V
E
L
R
S
A
D
E
I
M
L
T
S
A
T
K
E
I
L
P
V
T
S
L
D
-
D
L
P
V
Q
G
-
G
-
K
P
-
G
P
V
F
A
A
L
Y
D
A
Y
Q
R
------------------
11
PsiBlast_PDB
79.93
25%
-88
- C5 -
1A3G
1
ILVE_ECOLI
A:
[8-288]
----
I
W
F
N
G
E
M
V
R
W
----
E
D
A
K
V
H
V
M
S
H
A
L
H
Y
G
T
S
V
F
E
G
I
R
C
Y
-
D
----
S
HKGP-
V
----
V
-----
F
R
H
R
E
H
M
Q
R
L
H
D
S
A
K
I
Y
R
F
P
V
S
Q
S
I
D
E
L
M
E
A
C
R
D
V
I
R
K
N
--
N
L
T
S
A
Y
I
R
P
L
I
F
V
G
D
V
G
M
G
V
N
P
P
A
---
G
Y
S
T
-
D
V
-
I
-
I
A
-------
A
F
P
W
-----------
Q
G
I
D
A
M
V
S
S
W
----
N
R
-----
A
---
A
--
P
-
N
-
T
IP
T
A
A
K
A
-
G
-
G
-
N
-------------
Y
L
S
S
L
L
V
G
S
E
A
R
-
R
H
G
Y
Q
E
G
I
A
L
D
V
N
G
Y
I
S
E
G
A
G
E
N
L
F
E
V
K
D
G
V
L
F
T
P
P
F
T
S
S
A
L
P
G
I
T
R
D
A
I
I
K
L
A
K
E
L
G
I
E
V
R
E
Q
V
L
S
R
E
S
L
Y
L
A
D
E
V
F
M
S
G
T
A
A
E
I
T
P
V
R
S
V
D
-
G
I
Q
V
-
G
E
G
-
R
C
-
G
P
V
T
K
R
I
Q
Q
A
F
--------------------
7
PsiBlast_PDB
79.93
25%
-85
- C5 -
1I1L
2
ILVE_ECOLI
A:
[9-289]
----
I
W
F
N
G
E
M
V
R
W
----
E
D
A
K
V
H
V
M
S
H
A
L
H
Y
G
T
S
V
F
E
G
I
R
C
Y
-
D
----
S
HK
G
P
-
V
----
V
-----
F
R
H
R
E
H
M
Q
R
L
H
D
S
A
K
I
Y
R
F
P
V
S
Q
S
I
D
E
L
M
E
A
C
R
D
V
I
R
K
N
--
N
L
T
S
A
Y
I
R
P
L
I
F
V
G
D
V
G
M
G
V
N
P
P
A
---
G
Y
S
T
-
D
V
-
I
-
I
A
-------
A
F
P
W
G
A
Y
L
G
A
E
A
L
-
E
Q
G
I
D
A
M
V
S
S
W
----
N
R
-----
A
---
A
--
P
-
N
-
T
IP
T
A
A
K
A
-
G
-
G
-
N
-------------
Y
L
S
S
L
L
V
G
S
E
A
R
-
R
H
G
Y
Q
E
G
I
A
L
D
V
N
G
Y
I
S
E
G
A
G
E
N
L
F
E
V
K
D
G
V
L
F
T
P
P
F
T
S
S
A
L
P
G
I
T
R
D
A
I
I
K
L
A
K
E
L
G
I
E
V
R
E
Q
V
L
S
R
E
S
L
Y
L
A
D
E
V
F
M
S
G
T
A
A
E
I
T
P
V
R
S
V
D
-
G
I
Q
V
-
G
E
G
-
R
C
-
G
P
V
T
K
R
I
Q
Q
A
F
--------------------
8
PsiBlast_PDB
79.87
25%
-79
- C5 -
1I1M
2
ILVE_ECOLI
A:
[9-289]
----
I
W
F
N
G
E
M
V
R
W
----
E
D
A
K
V
H
V
M
S
H
A
L
H
Y
G
T
S
V
F
E
G
I
R
C
Y
-
D
----
S
HK
G
P
-
V
----
V
-----
F
R
H
R
E
H
M
Q
R
L
H
D
S
A
K
I
Y
R
F
P
V
S
Q
S
I
D
E
L
M
E
A
C
R
D
V
I
R
K
N
--
N
L
T
S
A
Y
I
R
P
L
I
F
V
G
D
V
G
M
G
V
N
P
P
A
---
G
Y
S
T
-
D
V
-
I
-
I
A
-------
A
F
P
W
G
A
Y
L
G
A
E
A
L
-
E
Q
G
I
D
A
M
V
S
S
W
----
N
R
-----
A
---
A
--
P
-
N
-
T
IP
T
A
A
K
A
-
G
-
G
-
N
-------------
Y
L
S
S
L
L
V
G
S
E
A
R
-
R
H
G
Y
Q
E
G
I
A
L
D
V
N
G
Y
I
S
E
G
A
G
E
N
L
F
E
V
K
D
G
V
L
F
T
P
P
F
T
S
S
A
L
P
G
I
T
R
D
A
I
I
K
L
A
K
E
L
G
I
E
V
R
E
Q
V
L
S
R
E
S
L
Y
L
A
D
E
V
F
M
S
G
T
A
A
E
I
T
P
V
R
S
V
D
-
G
I
Q
V
-
G
E
G
-
R
C
-
G
P
V
T
K
R
I
Q
Q
A
F
--------------------
24
HHSearch
79.78
24%
-92
- C5 -
3DAA
2
DAAA_BACYM
A:
[2-276]
---
Y
T
L
W
N
D
Q
I
V
K
D
----
E
E
V
K
I
D
K
E
D
R
G
Y
Q
F
G
D
G
V
Y
E
V
V
K
V
Y
-
N
----
G
-----
E
----
M
-----
F
T
V
N
E
H
I
D
R
L
Y
A
S
A
E
K
I
R
I
T
I
P
Y
T
K
D
K
F
H
Q
L
L
H
E
L
V
E
K
N
--
E
L
-----------
N
T
G
H
I
Y
F
Q
V
T
R
---
G
T
S
P
-
R
A
H
Q
-
F
P
E
N
T
V
K
P
V
I
I
G
Y
T
K
E
N
P
R
P
-
L
-
E
N
L
E
K
G
V
K
A
T
F
----
V
E
-----
D
---
I
--
R
-
W
-
L
--
R
C
D
I
K
-
S
-
L
-
N
-------------
L
L
G
A
V
L
A
K
Q
E
A
H
E
K
G
C
-
Y
E
A
I
L
H
R
-
N
N
T
V
T
E
G
S
S
S
N
V
F
G
I
K
D
G
I
L
Y
T
H
P
A
N
N
M
I
L
K
G
I
T
R
D
V
V
I
A
C
A
N
E
I
N
M
P
V
K
E
I
P
F
T
T
H
E
A
L
K
M
D
E
L
F
V
T
S
T
T
S
E
I
T
P
V
I
E
I
D
-
G
K
L
I
-
R
D
G
-
K
V
-
G
E
W
T
R
K
L
Q
K
Q
F
E
T
K
I
----------------
9
PsiBlast_PDB
79.26
25%
-77
- C5 -
1IYD
2
ILVE_ECOLI
A:
[9-289]
----
I
W
F
N
G
E
M
V
R
W
----
E
D
A
K
V
H
V
M
S
H
A
L
H
Y
G
T
S
V
F
E
G
I
R
C
Y
-
D
----
S
HK
G
P
-
V
----
V
-----
F
R
H
R
E
H
M
Q
R
L
H
D
S
A
K
I
Y
R
F
P
V
S
Q
S
I
D
E
L
M
E
A
C
R
D
V
I
R
K
N
--
N
L
T
S
A
Y
I
R
P
L
I
F
V
G
D
V
G
M
G
V
N
P
P
A
---
G
Y
S
T
-
D
V
-
I
-
I
A
-------
A
F
P
W
G
A
Y
L
G
A
E
A
L
-
E
Q
G
I
D
A
M
V
S
S
W
----
N
R
-----
A
---
A
--
P
-
N
-
T
IP
T
A
A
K
A
-
G
-
G
-
N
-------------
Y
L
S
S
L
L
V
G
S
E
A
R
-
R
H
G
Y
Q
E
G
I
A
L
D
V
N
G
Y
I
S
E
G
A
G
E
N
L
F
E
V
K
D
G
V
L
F
T
P
P
F
T
S
S
A
L
P
G
I
T
R
D
A
I
I
K
L
A
K
E
L
G
I
E
V
R
E
Q
V
L
S
R
E
S
L
Y
L
A
D
E
V
F
M
S
G
T
A
A
E
I
T
P
V
R
S
V
D
-
G
I
Q
V
-
G
E
G
-
R
C
-
G
P
V
T
K
R
I
Q
Q
A
F
--------------------
21
HHSearch
79.08
23%
-83
- C5 -
3WWH
2
?
A:
[38-322]
---
A
A
W
I
E
G
A
F
V
P
P
----
S
E
A
R
I
S
I
F
D
Q
G
Y
L
H
S
D
V
T
Y
T
V
F
H
V
W
-
N
----
G
-----
N
----
A
-----
F
R
L
D
D
H
I
E
R
L
F
S
N
A
E
S
M
R
I
I
P
P
L
T
Q
D
E
V
K
E
I
A
L
E
L
V
A
K
T
--
E
L
-----------
R
E
A
F
V
S
V
S
I
T
R
---
G
Y
S
S
T
P
G
-
E
-
R
D
I
T
K
H
R
P
Q
V
Y
M
Y
A
V
P
Y
Q
W
I
V
P
F
D
R
I
R
D
G
V
H
A
M
V
----
A
Q
SVRRT
P
---
R
--
S
-
S
-
I
--
D
P
Q
V
K
-
N
-
F
-
Q
-------------
W
G
D
L
I
R
A
V
Q
E
T
H
D
R
G
F
-
E
A
P
L
L
L
D
G
D
G
L
L
A
E
G
S
G
F
N
V
V
V
I
K
D
G
V
V
R
S
P
G
--
R
A
A
L
P
G
I
T
R
K
T
V
L
E
I
A
E
S
L
G
H
E
A
I
L
A
D
I
T
L
A
E
L
L
D
A
D
E
V
L
G
C
T
T
A
G
G
V
W
P
F
V
S
V
D
-
G
N
P
I
-
S
D
G
-
V
P
-
G
P
I
T
Q
S
I
I
R
R
Y
W
E
L
N
V
E
S
S
------------
10
PsiBlast_PDB
79.05
25%
-78
- C5 -
1IYE
1
ILVE_ECOLI
A:
[9-289]
----
I
W
F
N
G
E
M
V
R
W
----
E
D
A
K
V
H
V
M
S
H
A
L
H
Y
G
T
S
V
F
E
G
I
R
C
Y
-
D
----
S
HK
G
P
-
V
----
V
-----
F
R
H
R
E
H
M
Q
R
L
H
D
S
A
K
I
Y
R
F
P
V
S
Q
S
I
D
E
L
M
E
A
C
R
D
V
I
R
K
N
--
N
L
T
S
A
Y
I
R
P
L
I
F
V
G
D
V
G
M
G
V
N
P
P
A
---
G
Y
S
T
-
D
V
-
I
-
I
A
-------
A
F
P
W
G
A
Y
L
G
A
E
A
L
-
E
Q
G
I
D
A
M
V
S
S
W
----
N
R
-----
A
---
A
--
P
-
N
-
T
IP
T
A
A
K
A
-
G
-
G
-
N
-------------
Y
L
S
S
L
L
V
G
S
E
A
R
-
R
H
G
Y
Q
E
G
I
A
L
D
V
N
G
Y
I
S
E
G
A
G
E
N
L
F
E
V
K
D
G
V
L
F
T
P
P
F
T
S
S
A
L
P
G
I
T
R
D
A
I
I
K
L
A
K
E
L
G
I
E
V
R
E
Q
V
L
S
R
E
S
L
Y
L
A
D
E
V
F
M
S
G
T
A
A
E
I
T
P
V
R
S
V
D
-
G
I
Q
V
-
G
E
G
-
R
C
-
G
P
V
T
K
R
I
Q
Q
A
F
--------------------
5
PsiBlast_PDB
77.12
25%
-77
- C5 -
2DAA
2
DAAA_BACYM
A:
[6-277]
-------
N
D
Q
I
V
K
D
----
E
E
V
K
I
D
K
E
D
R
G
Y
Q
F
G
D
G
V
Y
E
V
V
K
V
Y
-
N
----
G
-----
E
----
M
-----
F
T
V
N
E
H
I
D
R
L
Y
A
S
A
E
K
I
R
I
T
I
P
Y
T
K
D
K
F
H
Q
L
L
H
E
L
V
E
K
N
--
E
L
N
T
---------
G
H
--
I
Y
F
Q
V
T
R
---
G
T
S
P
-
R
A
-
H
Q
F
P
E
N
T
V
K
P
V
I
I
G
Y
T
K
E
-
N
P
R
P
L
-
E
N
L
E
K
G
V
K
A
T
F
----
V
E
-----
D
---
I
--
R
-
W
-
L
--
R
C
D
I
K
-
S
-
L
-
N
-------------
L
L
G
A
V
L
A
K
Q
E
A
H
-
E
K
G
C
Y
E
A
I
-
L
H
R
N
N
T
V
T
E
G
S
S
S
N
V
F
G
I
K
D
G
I
L
Y
T
H
P
A
N
N
M
I
L
K
G
I
T
R
D
V
V
I
A
C
A
N
E
I
N
M
P
V
K
E
I
P
F
T
T
H
E
A
L
K
M
D
E
L
F
V
T
S
T
T
S
E
I
T
P
V
I
E
I
D
G
K
L
I
R
-
D
-
G
-
K
V
-
G
E
W
T
R
K
L
Q
K
Q
F
E
T
K
I
P
---------------
18
PsiBlast_PDB
76.97
25%
-73
- C5 -
3DAA
2
DAAA_BACYM
A:
[6-276]
-------
N
D
Q
I
V
K
D
----
E
E
V
K
I
D
K
E
D
R
G
Y
Q
F
G
D
G
V
Y
E
V
V
K
V
Y
-
N
----
G
-----
E
----
M
-----
F
T
V
N
E
H
I
D
R
L
Y
A
S
A
E
K
I
R
I
T
I
P
Y
T
K
D
K
F
H
Q
L
L
H
E
L
V
E
K
N
--
E
L
N
T
---------
G
H
--
I
Y
F
Q
V
T
R
---
G
T
S
P
-
R
A
-
H
Q
F
P
E
N
T
V
K
P
V
I
I
G
Y
T
K
E
-
N
P
R
P
L
-
E
N
L
E
K
G
V
K
A
T
F
----
V
E
-----
D
---
I
--
R
-
W
-
L
--
R
C
D
I
K
-
S
-
L
-
N
-------------
L
L
G
A
V
L
A
K
Q
E
A
H
-
E
K
G
C
Y
E
A
I
-
L
H
R
N
N
T
V
T
E
G
S
S
S
N
V
F
G
I
K
D
G
I
L
Y
T
H
P
A
N
N
M
I
L
K
G
I
T
R
D
V
V
I
A
C
A
N
E
I
N
M
P
V
K
E
I
P
F
T
T
H
E
A
L
K
M
D
E
L
F
V
T
S
T
T
S
E
I
T
P
V
I
E
I
D
G
K
L
I
R
-
D
-
G
-
K
V
-
G
E
W
T
R
K
L
Q
K
Q
F
E
T
K
I
----------------
17
PsiBlast_PDB
76.96
24%
-75
- C5 -
2DAB
1
DAAA_BACYM
A:
[6-280]
-------
N
D
Q
I
V
K
D
----
E
E
V
K
I
D
K
E
D
R
G
Y
Q
F
G
D
G
V
Y
E
V
V
K
V
Y
-
N
----
G
-----
E
----
M
-----
F
T
V
N
E
H
I
D
R
L
Y
A
S
A
E
K
I
R
I
T
I
P
Y
T
K
D
K
F
H
Q
L
L
H
E
L
V
E
K
N
--
E
L
N
T
---------
G
H
--
I
Y
F
Q
V
T
R
---
G
T
S
P
-
R
A
-
H
Q
F
P
E
N
T
V
K
P
V
I
I
G
Y
T
K
E
-
N
P
R
P
L
-
E
N
L
E
K
G
V
K
A
T
F
----
V
E
-----
D
---
I
--
R
-
W
-
L
--
R
C
D
I
K
-
S
-
L
-
N
-------------
L
L
G
A
V
L
A
K
Q
E
A
H
-
E
K
G
C
Y
E
A
I
-
L
H
R
N
N
T
V
T
E
G
S
S
S
N
V
F
G
I
K
D
G
I
L
Y
T
H
P
A
N
N
M
I
A
K
G
I
T
R
D
V
V
I
A
C
A
N
E
I
N
M
P
V
K
E
I
P
F
T
T
H
E
A
L
K
M
D
E
L
F
V
T
S
T
T
S
E
I
T
P
V
I
E
I
D
G
K
L
I
R
-
D
-
G
-
K
V
-
G
E
W
T
R
K
L
Q
K
Q
F
E
T
K
I
P
K
P
L
------------