@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00820: (2016-06-02 )
MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQEVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVGDDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVEQRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARPFITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATGVDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEISPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAHLMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR
Atome Classification :
(35 SA)
.........10........20-........30........40........50........60........70.......-.80.........90---........100-.-....-.-..110--....--.....120.......130.......140.......150.......160.......170.......180.......190.......200.....--------..210.......220.......230.......240.......250.......260.......270.......280.......290.....--..300-...-....---310-----..----......-.320.......330..-..------..-.-340.------....--...350....----.----.-----.----360.-......370.......380---.......390..-.....400-----........410.......420.......430-------.....--------------------------...440.......450.......460.......470.......480.......490.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQEEH
N
H
E
E
L
N
D
Q
L
Q
V
R
R
D
K
-
M
N
Q
L
R
DNGID
P
F
G
A
R
F
E
R
TH
Q
S
Q
E
V
I
S
A
Y
Q
D
L
T
K
E
E
L
EEK
A
I
E
V
T
IAG
R
M
MTKRGKG-KA-G
F
A
H
L
Q
DLE
G
Q
---
I
Q
I
Y
V
R
KDSV--G-D
D
Q
Y
-
E
-
I
FK----SSDL--
G
D
L
I
GVTG
K
V
F
KTNV
G
E
L
S
V
K
A
T
S
F
E
L
L
T
K
A
L
RPLPDKYH
G
L
K
D
V
E
Q
R
Y
R
Q
R
Y
L
D
L
I
VNPDSK
H
T
F
I
T
R
S
K
I
I
Q
A
M
R
R
Y
LDDHG
Y
L
E
VETPTM--------HSIPGGASAR
P
F
I
THHNALD
I
P
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
NEGVSTRHNPE
F
T
M
I
E
L
Y
E
A
Y
A
D
Y
K
D
I
M
S
L
T
E
N
L
V
A
H
I
--
A
Q
E
V
L
-GT
T
-
T
I
QY---G-------EE----QIDLKP-E
W
K
R
I
H
M
V
D
A
V
K
E
ATG-V
D
------
F
W
-
E
-
E
V
-
T
------
V
E
Q
A
--
R
E
Y
A
K
EH
E
V
E
----I----K-----D----SM
T
V
-
G
H
I
I
N
E
F
F
E
Q
K
I
E
E
T
LIQ
P
---
T
F
IYGHPVEISP-LAKKNPE------DPRFT
D
R
F
E
L
F
I
V
GREHA
N
A
F
TELNDP
I
D
Q
--------
R
E
R
F
E
--------------------------
A
Q
L
K
EREAGNDEAHL
M
D
E
D
F
V
E
A
L
EYGMPPTGGL
G
I
G
I
D
R
L
V
M
L
LTNAPS
I
R
D
V
L
LF
P
Q
MRQR
27
PsiBlast_CBE
94.32
78%
-89
- C5 -
3A74
5
SYK_GEOSE
D:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
29
PsiBlast_CBE
93.99
78%
-88
- C5 -
3A74
5
SYK_GEOSE
B:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
65
HHSearch
93.87
79%
-89
- C5 -
3A74
5
SYK_GEOSE
A:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
3
PsiBlast_PDB
93.61
78%
-89
- C5 -
3A74
5
SYK_GEOSE
A:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
28
PsiBlast_CBE
93.56
78%
-89
- C5 -
3A74
5
SYK_GEOSE
C:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
24
PsiBlast_CBE
93.46
78%
-90
- C5 -
3E9H
2
SYK_GEOSE
D:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
1
PsiBlast_PDB
93.46
78%
-88
- C5 -
3E9H
2
SYK_GEOSE
A:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
26
PsiBlast_CBE
93.36
78%
-90
- C5 -
3E9H
2
SYK_GEOSE
B:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
2
PsiBlast_PDB
93.33
78%
-87
- C5 -
3E9I
4
SYK_GEOSE
A:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
22
PsiBlast_CBE
93.12
78%
-90
- C5 -
3E9I
4
SYK_GEOSE
C:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
21
PsiBlast_CBE
93.11
78%
-89
- C5 -
3E9I
4
SYK_GEOSE
D:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
25
PsiBlast_CBE
92.56
78%
-88
- C5 -
3E9H
2
SYK_GEOSE
C:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
23
PsiBlast_CBE
91.88
78%
-87
- C5 -
3E9I
4
SYK_GEOSE
B:
[4-492]
---------
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
---
I
Q
I
Y
V
R
Q
D
D
V
--
G
-
E
Q
Q
Y
-
E
-
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
--
A
T
E
V
L
-
G
T
T
-
K
I
Q
Y
---
G
-------
E
H
----
L
V
D
L
T
P
-
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
------
F
W
-
R
-
Q
M
-
S
------
D
E
E
A
--
R
E
L
A
K
E
H
G
V
E
----
V
----
A
-----
P
----
H
M
T
F
-
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
------
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
--------
R
Q
R
F
E
--------------------------
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
4
PsiBlast_PDB
86.24
54%
-79
- C5 -
1LYL
1
SYK2_ECOLI
A:
[14-501]
----------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
D
S
L
--
P
-
E
G
V
Y
N
D
-
Q
F
K
----
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
E
V
L
-
G
T
T
-
K
V
T
Y
---
G
-------
E
H
----
V
F
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
-
D
-
L
D
-
N
------
F
D
A
A
--
K
A
L
A
E
S
I
G
I
T
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
31
PsiBlast_CBE
85.38
54%
-81
- C5 -
1LYL
1
SYK2_ECOLI
B:
[14-501]
----------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
D
S
L
--
P
-
E
G
V
Y
N
D
-
Q
F
K
----
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
E
V
L
-
G
T
T
-
K
V
T
Y
---
G
-------
E
H
----
V
F
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
-
D
-
L
D
-
N
------
F
D
A
A
--
K
A
L
A
E
S
I
G
I
T
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
30
PsiBlast_CBE
84.78
54%
-81
- C5 -
1LYL
1
SYK2_ECOLI
C:
[14-501]
----------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
D
S
L
--
P
-
E
G
V
Y
N
D
-
Q
F
K
----
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
E
V
L
-
G
T
T
-
K
V
T
Y
---
G
-------
E
H
----
V
F
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
-
D
-
L
D
-
N
------
F
D
A
A
--
K
A
L
A
E
S
I
G
I
T
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
5
PsiBlast_PDB
84.37
54%
-80
- C5 -
1E1O
9
SYK2_ECOLI
A:
[13-501]
---------
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
D
S
L
--
P
-
E
G
V
Y
N
D
-
Q
F
K
----
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
E
V
L
-
G
T
T
-
K
V
T
Y
---
G
-------
E
H
----
V
F
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
-
D
-
L
D
-
N
------
F
D
A
A
--
K
A
L
A
E
S
I
G
I
T
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
6
PsiBlast_PDB
84.13
54%
-78
- C5 -
1E1T
11
SYK2_ECOLI
A:
[13-501]
---------
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
D
S
L
--
P
-
E
G
V
Y
N
D
-
Q
F
K
----
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
E
V
L
-
G
T
T
-
K
V
T
Y
---
G
-------
E
H
----
V
F
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
-
D
-
L
D
-
N
------
F
D
A
A
--
K
A
L
A
E
S
I
G
I
T
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
55
Fugue
84.12
53%
-77
- C5 -
1LYL
1
SYK2_ECOLI
A:
[14-502]
----------
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
-
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
-----
D
-
S
L
P
E
-
G
-
V
Y
N
DQFK
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
-------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
E
V
L
-
G
T
T
-
K
V
T
Y
---
G
-------
E
H
----
V
F
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
-
E
T
------
D
M
-
A
-
D
L
D
N
------
F
D
A
A
--
K
A
L
A
E
S
I
G
I
T
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
-P
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-
9
PsiBlast_PDB
84.05
53%
-76
- C5 -
1BBU
1
SYK1_ECOLI
A:
[13-501]
---------
D
L
N
N
E
L
K
T
R
R
E
K
-
L
A
N
L
R
E
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
K
E
N
E
E
L
E
A
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
D
D
L
--
P
-
E
G
V
Y
N
E
-
Q
F
K
----
K
W
D
L
--
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
D
I
L
-
G
K
T
-
E
V
T
Y
---
G
-------
D
V
----
T
L
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
-
D
-
L
D
-
N
------
F
D
S
A
--
K
A
I
A
E
S
I
G
I
H
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
Q
R
F
L
--------------------------
D
Q
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
66
HHSearch
83.96
54%
-78
- C5 -
1E1O
9
SYK2_ECOLI
A:
[12-502]
--------
I
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
D
S
L
--
P
-
E
G
V
Y
-
N
D
Q
F
K
----
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
E
V
L
-
G
T
T
-
K
V
T
Y
---
G
-------
E
H
----
V
F
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
-
E
T
------
D
M
A
D
-
L
D
-
N
------
F
D
A
A
--
K
A
L
A
E
S
I
G
I
T
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-
7
PsiBlast_PDB
83.93
54%
-80
- C5 -
1E22
11
SYK2_ECOLI
A:
[13-501]
---------
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
D
S
L
--
P
-
E
G
V
Y
N
D
-
Q
F
K
----
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
E
V
L
-
G
T
T
-
K
V
T
Y
---
G
-------
E
H
----
V
F
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
-
D
-
L
D
-
N
------
F
D
A
A
--
K
A
L
A
E
S
I
G
I
T
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
8
PsiBlast_PDB
83.83
54%
-80
- C5 -
1E24
7
SYK2_ECOLI
A:
[13-501]
---------
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
---
I
Q
L
Y
V
A
R
D
S
L
--
P
-
E
G
V
Y
N
D
-
Q
F
K
----
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
--
A
Q
E
V
L
-
G
T
T
-
K
V
T
Y
---
G
-------
E
H
----
V
F
D
F
G
K
-
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
------
M
A
-
D
-
L
D
-
N
------
F
D
A
A
--
K
A
L
A
E
S
I
G
I
T
----
V
----
E
-----
K
----
S
W
G
L
-
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
------
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
--------
A
E
R
F
Q
--------------------------
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
67
HHSearch
82.67
52%
-79
- C5 -
4EX5
1
SYK_BURTA
A:
[36-527]
----------
E
N
Q
I
V
A
E
R
R
D
K
-
L
R
A
L
R
D
Q
G
I
A
-
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
K
S
L
E
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
-
S
F
A
T
V
Q
D
G
S
G
Q
---
I
Q
F
F
V
T
P
A
D
V
--
G
-
A
E
T
Y
-
D
-
A
F
K
----
K
W
D
L
--
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
--------
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
--
A
V
D
A
L
-
G
T
A
-
T
I
Q
Y
---
Q
-------
G
R
----
E
L
D
L
A
Q
-
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
A
P
-
S
Y
------
T
D
-
G
Q
L
S
-
D
------
D
A
F
L
--
R
S
E
L
K
R
L
G
V
D
----
V
TQPA
F
-----
L
----
N
A
G
I
-
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
---
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
------
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
--------
A
A
R
F
K
--------------------------
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
-
11
PsiBlast_PDB
81.90
51%
-82
- C5 -
4EX5
1
SYK_BURTA
A:
[43-527]
-----------------
R
R
D
K
-
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
K
S
L
E
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
-
S
F
A
T
V
Q
D
G
S
G
Q
---
I
Q
F
F
V
T
P
A
D
V
--
G
-
A
E
T
Y
-
D
-
A
F
K
----
K
W
D
L
--
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
--------
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
--
A
V
D
A
L
-
G
T
A
-
T
I
Q
Y
---
Q
-------
G
R
----
E
L
D
L
A
Q
-
P
F
H
R
L
T
I
T
Q
A
I
Q
K
-
Y
A
-
P
S
------
Y
T
-
D
-
G
Q
-
L
------
S
D
D
A
F
L
R
S
E
L
K
R
L
G
V
D
----
V
----
T
-----
Q
PAFL
N
A
G
I
-
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
---
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
------
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
--------
A
A
R
F
K
--------------------------
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
-
68
HHSearch
81.58
43%
-76
* C5 *
4YCU
4
SYK_HUMAN
A:
[4-508]
---------
D
P
N
Q
Y
Y
K
I
R
S
Q
A
-
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
H
-
L
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
G
K
L
-
I
F
Y
D
L
R
G
E
G
V
K
---
L
Q
V
M
A
N
S
R
N
Y
--
K
S
E
E
E
F
-
I
H
I
N
N
----
K
L
R
R
--
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
--------
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
--
V
K
H
I
T
-
G
S
Y
-
K
V
T
Y
---
H
PDGPE
G
Q
A
Y
----
D
V
D
F
T
P
-
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
-
M
K
------
L
P
-
E
-
T
N
-
L
FET
E
E
T
R
K
I
L
--
D
D
I
C
V
A
K
A
V
E
----
C
----
P
-----
P
----
P
R
T
T
-
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
---
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
------
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
--------
R
Q
L
F
E
--------------------------
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
P
E
44
PsiBlast_CBE
81.34
43%
-78
- C5 -
4YCU
4
SYK_HUMAN
B:
[6-506]
-----------
N
Q
Y
Y
K
I
R
S
Q
A
-
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
-
H
L
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
----
G
K
L
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
--
K
-
S
E
E
E
-
F
-
I
H
I
----
N
N
K
L
RR
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
-----
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
--------
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
--
V
K
H
I
T
-
G
S
Y
-
K
V
T
Y
HPD
G
-------
P
E
G
Q
A
Y
D
V
D
F
T
P
-
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
-
M
K
LPETNL
F
E
-
T
-
E
E
-
T
------
R
K
I
L
--
D
D
I
C
V
A
K
A
V
E
----
C
----
P
-----
P
----
P
R
T
T
-
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
---
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
------
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
--------
R
Q
L
F
E
--------------------------
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
--
32
PsiBlast_CBE
81.24
51%
-82
- C5 -
4EX5
1
SYK_BURTA
B:
[43-527]
-----------------
R
R
D
K
-
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
K
S
L
E
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
-
S
F
A
T
V
Q
D
G
S
G
Q
---
I
Q
F
F
V
T
P
A
D
V
--
G
-
A
E
T
Y
-
D
-
A
F
K
----
K
W
D
L
--
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
-------
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
--------
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
--
A
V
D
A
L
-
G
T
A
-
T
I
Q
Y
---
Q
-------
G
R
----
E
L
D
L
A
Q
-
P
F
H
R
L
T
I
T
Q
A
I
Q
K
-
Y
A
-
P
S
------
Y
T
-
D
-
G
Q
-
L
------
S
D
D
A
F
L
R
S
E
L
K
R
L
G
V
D
----
V
----
T
-----
Q
PAFL
N
A
G
I
-
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
---
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
------
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
--------
A
A
R
F
K
--------------------------
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
-
17
PsiBlast_PDB
80.84
43%
-75
- C5 -
4YCU
4
SYK_HUMAN
A:
[6-506]
-----------
N
Q
Y
Y
K
I
R
S
Q
A
-
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
-
H
L
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
----
G
K
L
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
--
K
-
S
E
E
E
-
F
-
I
H
I
----
N
N
K
L
RR
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
--------
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
--
V
K
H
I
T
-
G
S
Y
-
K
V
T
Y
H
PD
G
-------
P
E
G
Q
A
Y
D
V
D
F
T
P
-
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
-
M
K
L
P
E
TNL
F
E
-
T
-
E
E
-
T
------
R
K
I
L
--
D
D
I
C
V
A
K
A
V
E
----
C
----
P
-----
P
----
P
R
T
T
-
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
---
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
------
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
--------
R
Q
L
F
E
--------------------------
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
--
70
HHSearch
79.03
44%
-70
- C5 -
4UP7
1
?
A:
[11-569]
-----------
K
Q
L
F
L
N
R
C
K
D
-
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
--
S
D
D
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
S
A
L
-
M
F
I
D
L
H
D
S
Q
T
K
---
L
Q
I
M
L
N
K
S
A
Y
--
E
N
K
E
D
F
-
V
S
L
T
K
----
M
I
Y
R
--
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
--------
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
--
V
K
D
I
T
-
G
G
S
T
K
L
E
I
K---FV
T
E
K
--
K
M
----
V
L
D
F
T
A
-
P
F
K
R
I
S
Y
V
H
A
L
E
E
K
F
G
-
E
K
------
I
P
-
R
-
P
L
-
D
------
G
P
E
A
--
L
T
F
L
K
K
Q
A
I
R
F
N
A
I
C
----
A
-----
E
----
P
Q
T
T
-
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
---
T
F
V
C
D
Q
P
Q
L
M
S
P
-
L
A
K
Y
H
R
S
------
E
P
E
L
T
E
R
F
E
L
F
I
L
K
R
E
I
A
N
A
Y
T
E
L
N
N
P
I
V
Q
--------
R
S
N
F
E
--------------------------
Q
Q
A
K
D
K
A
A
G
D
D
E
A
Q
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
P
-
20
PsiBlast_PDB
69.17
35%
-73
- C5 -
4UPA
1
?
A:
[9-568]
----------
L
S
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
D
I
--
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
---
L
Q
I
M
L
N
K
S
A
Y
EN
K
-
E
D
F
V
-
S
-
L
T
K
----
M
I
Y
R
--
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
--------
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
--
V
K
D
I
T
G
G
S
T
-
K
L
E
I
---
K
------------------------------------------------------------------------
K
K
M
V
----
L
----
D
FTAP
F
K
----
R
I
S
Y
-
V
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
-
I
C
A
E
-
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
YHRSEPE
L
T
E
R
F
E
L
F
I
LKREI
A
N
A
Y
TELNN
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
-------
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
--
52
PsiBlast_CBE
68.49
35%
-67
- C5 -
4UP7
1
?
A:
[9-568]
----------
L
S
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
D
I
--
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
---
L
Q
I
M
L
N
K
S
A
Y
EN
K
-
E
D
F
V
-
S
-
L
T
K
----
M
I
Y
R
--
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
--------
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
--
V
K
D
I
T
G
G
S
T
-
K
L
E
I
---
K
--------------------------------------------------------------------
F
V
T
E
K
K
M
V
----
L
----
D
FTAP
F
K
----
R
I
S
Y
-
V
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
-
I
C
A
E
-
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
YHRSEPEL
T
E
R
F
E
L
F
I
LKREI
A
N
A
Y
TELNN
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
A
G
D
D
E
A
Q
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
--
19
PsiBlast_PDB
67.31
35%
-71
- C5 -
4UP9
1
?
A:
[9-568]
----------
L
S
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
D
I
--
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
---
L
Q
I
M
L
N
K
S
A
Y
EN
K
-
E
D
F
V
-
S
-
L
T
K
----
M
I
Y
R
--
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
--------
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
--
V
K
D
I
T
G
G
S
T
-
K
L
E
I
---
K
-------------------------------------------------------------------------
K
M
V
----
L
----
D
FTAP
F
K
----
R
I
S
Y
-
V
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
-
I
C
A
E
-
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
YHRSEPE
L
T
E
R
F
E
L
F
I
LKREI
A
N
A
Y
TELNN
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
-------
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
--
54
PsiBlast_CBE
51.78
31%
-62
- C5 -
3G1Z
4
EPMA_SALTY
A:
[16-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
SQATVTDI
H
L
F
P
F
E
T
R
---
F
V
G
---
S
Q
G
I
N
L
Y
L
M
T
S
P
E
Y
H
M
K
R
L
L
A
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
H
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
Q
P
A
E
-
S
L
S
-
Y
Q
Q
A
---
F
-------
Q
R
----
H
L
E
I
D
P
L
S
A
D
K
T
Q
L
R
E
A
---
A
A
K
-
L
D
------
L
S
-
N
-
I
A
-
D
------
T
E
E
D
--
R
D
T
L
----
L
Q
----
L
----
L
-----
F
----
T
M
G
V
E
P
H
I
G
K
E
-----------
K
P
---
T
F
I
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
------
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
--------
Q
Q
R
F
E
--------------------------
Q
D
N
R
K
R
A
A
R
-
L
P
Q
Q
P
I
D
Q
N
L
L
D
A
L
A
A
G
L
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
S
L
A
D
V
I
A
F
------
53
PsiBlast_CBE
50.95
31%
-63
- C5 -
3G1Z
5
EPMA_SALTY
B:
[16-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
SQATVTDI
H
L
F
P
F
E
T
R
---
F
V
G
P
---
Q
G
I
N
L
Y
L
M
T
S
P
E
Y
H
M
K
R
L
L
A
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
H
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
Q
P
A
E
-
S
L
S
-
Y
Q
Q
A
---
F
-------
Q
R
----
H
L
E
I
D
P
L
S
A
D
K
T
Q
L
R
E
A
---
A
A
K
-
L
D
------
L
---------------
E
E
D
--
R
D
T
L
----
L
Q
----
L
----
L
-----
F
----
T
M
G
V
E
P
H
I
G
K
E
-----------
K
P
---
T
F
I
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
------
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
--------
Q
Q
R
F
E
--------------------------
Q
D
N
R
K
---
R
G
L
P
Q
Q
P
I
D
Q
N
L
L
D
A
L
A
A
G
L
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
S
L
A
D
V
I
A
F
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