@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00860: (2016-06-02 )
MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEGIAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANTPTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRFQPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAIDLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHSRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDEESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNHKDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLSIELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVEDGEFVVKTTAKTN
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70-----....------...---..80........90........100.......110.......120.......130.......140...--....150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......-270........280.......290..-......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......-440.......450.......460.----------------------------------------------------------......------------------------------------------------------------470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.--......--800.......810
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMF
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
LGHNNI
G
T
E
H
I
L
L
G
L
VREGE
G
I
A
A
K
A
L
Q
A
LGL
G
S
E
K
I
Q
K
E
V
E
S
L
I
GR------
G
Q
E
M
------
S
Q
T---IHYTPRA
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
YV
G
T
E
H
I
L
L
G
L
IREG
E
G
V
A
A
R
V
L
N
N
LGV
S
L
N
K
A
R
Q
Q
V
L
Q
L
LGSN--ETGSSAAGTNSNANTP
T
L
D
S
L
A
R
D
L
T
A
I
AKEDSLDPVIGR
S
K
E
I
Q
R
V
I
E
V
L
S
R
RTKNN
P
V
L
I
GEPGV
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
NNE
V
P
E
I
L
RDK
R
V
M
T
L
DM
G
T
V
VAGTKYR
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
-QA-G
N
I
I
L
F
I
D
E
L
H
T
L
I
GAGGA-EGA-I
D
A
S
N
ILKPSLARG
E
L
Q
C
IGAT
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
RRFQ
P
I
QVDQPS
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
EAHH
R
V
S
I
T
D
D
A
I
E
A
A
V
K
LS
D
R
YISDRFL
P
D
K
A
I
D
L
I
D
EAG
S
K
V
R
L
R
SFTTPP
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
DAA
V
Q
S
Q
E
F
E
K
A
-ASL
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K----------------------------------------------------------QGQENS------------------------------------------------------------EV
T
V
D
D
I
A
M
V
V
S
SWTGV
P
V
S
K
I
AQT
E
T
D
K
L
L
N
M
E
N
I
L
H
S
RVIGQ
D
E
A
V
V
A
V
A
K
A
V
R
R
A
RAGLKDPKRPIG
S
F
I
F
LGPTGV
G
K
T
E
L
A
R
A
L
A
E
S
IFGDEE
S
M
I
R
I
D
M
S
E
Y
M
E
K
HSTSRLVGSPPGYVGYDEG
G
Q
L
T
E
K
V
RRKP
Y
S
V
V
L
L
D
E
I
E
K
AH
P
D
V
F
N
I
L
L
Q
V
L
EDGRLTDSKG
R
T
V
D
FR
N
T
I
L
I
M
TSNV
G
A
S
E
L
KRNK
Y
V
G
F
N
VQDETQN
H
K
D
M
K
D
K
V
M
G
E
L
K
R
AF
R
P
E
F
I
N
R
I
D
E
I
I
V
F
HSL
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
EQDL
S
I
E
LTDAA
K
A
K
V
A
EEGVDLEYG
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
RGNIHKG
Q
H
I
V
--
L
D
VEDG--
E
F
V
V
K
TTAKTN
4
PsiBlast_PDB
91.33
99%
-80
- C2 -
3J3U
-
CLPC_BACSU
A:
[3-807]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
------
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
--
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
-
Q
A
-
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
-
E
G
A
-
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
-
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
----------------------------------------------------------
Q
G
Q
E
N
S
------------------------------------------------------------
E
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
V
Q
D
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
--
L
D
V
E
D
G
--
E
F
V
V
K
T
T
A
---
1
PsiBlast_PDB
90.50
99%
-78
- C2 -
3J3S
-
CLPC_BACSU
A:
[3-807]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
------
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
--
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
-
Q
A
-
G
N
I
I
L
F
I
D
E
L
H
T
L
I
G
A
G
G
A
-
E
G
A
-
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
-
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
----------------------------------------------------------
Q
G
Q
E
N
S
------------------------------------------------------------
E
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
V
Q
D
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
--
L
D
V
E
D
G
--
E
F
V
V
K
T
T
A
---
3
PsiBlast_PDB
90.20
99%
-79
- C2 -
3J3R
-
CLPC_BACSU
A:
[3-807]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
------
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
--
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
-
Q
A
-
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
-
E
G
A
-
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
-
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
----------------------------------------------------------
Q
G
Q
E
N
S
------------------------------------------------------------
E
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
V
Q
D
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
--
L
D
V
E
D
G
--
E
F
V
V
K
T
T
A
---
2
PsiBlast_PDB
89.17
99%
-75
- C1 -
3J3T
-
CLPC_BACSU
A:
[3-807]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
------
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
--
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
-
Q
A
-
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
-
E
G
A
-
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
-
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
----------------------------------------------------------
Q
G
Q
E
N
S
------------------------------------------------------------
E
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
V
Q
D
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
--
L
D
V
E
D
G
--
E
F
V
V
K
T
T
A
---
97
HHSearch
88.67
99%
-99
- C2 -
3PXI
-
CLPC_BACSU
A:
[3-807]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
------
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
--
E
T
G
S
-----
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
-
Q
A
-
G
N
I
I
L
F
I
D
A
----------------------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
--
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
-
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
----------------------------------------------------------
Q
G
Q
E
---------------------------------------------------------------
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
--------------
S
---
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
K
D
K
---------------------
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
--
L
D
V
E
D
G
--
E
F
V
V
K
T
T
A
---
5
PsiBlast_PDB
87.85
93%
-99
- C2 -
3PXI
-
CLPC_BACSU
A:
[3-807]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
------
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
--
E
T
G
S
-----
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
-
Q
A
-
G
N
I
I
L
F
I
D
-------------
A
---------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
--
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
-
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
----------------------------------------------------------
Q
G
Q
E
---------------------------------------------------------------
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
-----------------
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
---------------------
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
--
L
D
V
E
D
G
--
E
F
V
V
K
T
T
A
---
84
Fugue
78.46
49%
-81
- C1 -
1QVR
7
CLPB_THET8
A:
[4-850]
---
E
R
W
T
Q
A
A
R
E
A
L
A
Q
A
Q
V
L
A
Q
R
M
K
H
Q
A
I
D
L
P
H
L
W
A
V
L
L
K
D
E
R
S
L
A
W
R
L
L
E
K
A
G
A
D
P
K
A
L
K
E
L
Q
E
R
E
L
A
R
------
L
P
K
V
------
E
G
A
EVG
Q
Y
L
T
S
R
L
S
G
A
L
N
R
A
E
G
L
M
E
E
L
K
D
R
Y
V
A
V
D
T
L
V
L
A
L
A
E
A
T
P
G
L
-------------
P
G
L
E
A
L
K
G
A
L
K
E
L
--
R
G
G
R
T
V
Q
T
E
H
A
E
S
T
Y
N
A
L
E
Q
Y
G
I
D
L
T
R
L
A
A
E
G
K
L
D
P
V
I
G
R
D
E
E
I
R
R
V
I
Q
I
L
L
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
V
E
G
L
A
Q
R
I
V
K
G
D
V
P
E
G
L
K
G
K
R
I
V
S
L
Q
M
-----------
E
F
E
E
R
L
K
A
V
I
Q
E
V
V
-
Q
S
Q
G
E
V
I
L
F
I
D
E
L
---------------------
K
P
A
L
A
R
G
E
L
R
L
I
G
A
T
T
L
D
E
Y
R
E
I
-
E
K
D
P
A
L
E
R
R
F
Q
P
V
Y
V
D
E
P
T
V
E
E
T
I
S
I
L
R
G
L
K
E
K
Y
E
V
H
H
G
V
R
I
S
D
S
A
I
I
A
A
A
T
L
S
H
R
Y
I
T
E
R
R
L
P
D
K
A
I
D
L
I
D
E
A
A
A
R
L
R
M
A
L
E
S
A
P
E
E
I
D
A
L
E
R
K
K
L
Q
L
E
I
E
R
E
A
L
K
K
E
K
D
P
D
S
Q
-
E
R
L
K
A
I
E
A
E
I
A
K
L
T
E
E
I
A
K
L
R
A
E
W
----------------------------------------------------------
E
R
E
R
E
I
L
R
K
L
R
E
A
Q
H
R
L
D
E
V
R
R
E
I
E
L
A
E
R
Q
YDLN
R
A
A
E
L
R
Y
G
E
L
P
K
L
E
A
E
V
E
A
L
S
E
K
L
RGARFVRL
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
-------
W
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
A
---
98
HHSearch
77.43
57%
-96
- C1 -
4CIU
2
CLPB_ECOLI
A:
[17-711]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
K
K
Y
T
I
D
L
T
E
R
A
E
Q
G
K
L
D
P
V
I
G
R
D
E
E
I
R
R
T
I
Q
V
L
Q
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
V
E
G
L
A
Q
R
I
I
N
G
E
V
P
E
G
L
K
G
R
R
V
L
A
L
D
M
G
A
L
V
A
-----
G
E
F
E
E
R
L
K
G
V
L
N
D
L
A
K
Q
E
-
G
N
V
I
L
F
I
D
A
L
H
T
M
V
G
----------
D
A
G
N
M
L
K
P
A
L
A
R
G
E
L
H
C
V
G
A
T
T
L
D
E
Y
R
Q
Y
I
---------
F
Q
K
V
F
V
A
E
P
S
V
E
D
T
I
A
I
L
R
G
L
K
E
R
Y
E
L
H
H
H
V
Q
I
T
D
P
A
I
V
A
A
A
T
L
S
H
R
Y
I
A
D
R
Q
L
P
D
K
A
I
D
L
I
D
E
A
A
S
S
I
R
M
Q
I
D
S
K
P
E
E
L
D
R
L
D
R
R
I
I
Q
L
K
L
E
Q
Q
A
L
M
--------L
D
M
L
N
E
E
L
S
D
K
E
R
Q
Y
S
E
L
E
E
E
W
K
A
E
K
A
S
L
S
G
T
Q
T
I
K
A
E
L
E
Q
A
K
I
A
I
E
Q
A
R
R
VGDLA
R
M
S
E
L
Q
Y
GK
I
P
E
L
E
K
Q
L
E
A
A
T
Q
L
E
G
K
T
M
R
L
L
R
N
------------------------------------------------------------
K
V
T
D
A
E
I
A
E
V
L
A
R
W
T
G
I
P
V
S
R
M
M
E
S
E
R
E
K
L
L
R
M
E
Q
E
L
H
H
R
V
I
G
Q
N
E
A
V
D
A
V
S
N
A
I
R
R
S
R
A
G
L
A
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
C
K
A
L
A
N
F
M
F
D
S
D
E
A
M
V
R
I
D
M
S
E
F
M
E
K
H
S
V
S
R
L
V
G
A
---------
G
G
Y
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
L
D
A
V
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
D
D
G
R
L
T
D
G
Q
G
R
T
V
D
F
R
N
T
V
V
I
M
T
S
N
L
G
S
D
L
I
Q
E
R
F
------
L
----
D
Y
A
H
M
K
E
L
V
L
G
V
V
S
H
N
F
R
P
E
F
I
N
R
I
D
E
V
V
V
F
H
P
L
G
E
Q
H
I
A
S
I
A
Q
I
Q
L
K
R
L
Y
K
R
L
E
E
R
G
Y
E
I
H
I
S
D
E
A
L
K
L
L
S
E
N
G
Y
D
P
V
Y
G
A
R
P
L
K
R
A
I
Q
Q
Q
I
E
N
P
L
A
Q
Q
I
L
S
G
E
L
V
P
G
K
V
I
R
--
L
E
V
N
E
D
--
R
I
---------
96
HHSearch
74.54
41%
-88
- C1 -
1R6B
5
CLPA_ECOLI
X:
[1-746]
----
M
L
N
Q
E
L
E
L
S
L
N
M
A
F
A
R
A
R
E
H
R
H
E
F
M
T
V
E
H
L
L
L
A
L
L
S
N
P
S
--
A
R
E
A
L
E
A
C
S
V
D
L
V
A
L
R
Q
E
L
E
A
F
I
E
Q
------
T
T
P
V
LPASEE
E
R
D
---
T
Q
P
T
L
S
F
Q
R
V
L
Q
R
A
V
F
H
V
Q
S
S
G
R
N
E
V
T
G
A
N
V
L
V
A
I
F
S
E
Q
E
S
Q
A
A
Y
L
L
R
K
H
E
V
S
R
L
D
V
V
N
F
I
S
H
G
-----------------------
L
E
N
F
T
T
N
L
N
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
R
G
D
F
E
K
R
F
K
A
L
L
K
Q
L
E
-
Q
D
-
T
N
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
S
G
G
Q
-
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
G
A
R
A
R
L
M
P
V
S
K
--------------------------------------------------------------------------------------------------------------------
R
K
K
------------------------------------------------------------
T
V
N
V
A
D
I
E
S
V
V
A
R
I
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
D
R
L
K
M
L
V
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
K
A
L
G
---
I
E
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
G
F
D
Q
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
-------------------------
A
M
E
E
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
N
E
L
L
F
G
S
L
V
D
G
G
Q
V
T
--
V
A
L
D
K
E
KN
E
L
T
Y
G
F
-----
8
PsiBlast_PDB
72.31
38%
-83
- C1 -
1R6B
5
CLPA_ECOLI
X:
[22-742]
-------------------------
H
E
F
M
T
V
E
H
L
L
L
A
L
L
S
N
P
S
--
A
R
E
A
L
E
A
C
S
V
D
L
V
A
L
R
Q
E
L
E
A
F
I
E
Q
TTPVLP
A
S
E
E
------
E
R
D
---
T
Q
P
T
L
S
F
Q
R
V
L
Q
R
A
V
F
H
V
Q
S
S
G
R
N
E
V
T
G
A
N
V
L
V
A
I
F
S
E
Q
E
S
Q
A
A
Y
L
L
R
K
H
E
V
S
----
R
L
D
V
V
N
F
I
S
H
G
-------------------
L
E
N
F
T
T
N
L
N
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
R
G
D
F
E
K
R
F
K
A
L
L
K
Q
L
E
-
Q
D
-
T
N
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
-
S
G
G
Q
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
G
A
R
A
R
L
M
P
V
S
---------------
K
R
K
K
T
V
N
V
A
D
I
E
S
V
V
A
-
R
I
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
----------------------------------------------------------------------------------------------------------------------------------
D
R
L
K
M
L
V
------------------------------
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
K
A
L
-
G
I
E
--
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
G
F
D
Q
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
-------------------------
A
M
E
E
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
N
E
L
L
F
G
S
L
V
D
G
G
Q
V
T
VA
L
D
K
E
K
N
--
E
L
---------
7
PsiBlast_PDB
71.15
38%
-84
* C1 *
1KSF
12
CLPA_ECOLI
X:
[22-742]
-------------------------
H
E
F
M
T
V
E
H
L
L
L
A
L
L
S
N
P
S
--
A
R
E
A
L
E
A
C
S
V
D
L
V
A
L
R
Q
E
L
E
A
F
I
E
Q
TTPVLP
A
S
E
E
------
E
R
D
---
T
Q
P
T
L
S
F
Q
R
V
L
Q
R
A
V
F
H
V
Q
S
S
G
R
N
E
V
T
G
A
N
V
L
V
A
I
F
S
E
Q
E
S
Q
A
A
Y
L
L
R
K
H
E
V
S
----
R
L
D
V
V
N
F
I
S
H
G
TR-----------------
L
E
N
F
T
T
N
L
N
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
R
G
D
F
E
K
R
F
K
A
L
L
K
Q
L
E
-
Q
D
-
T
N
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
-
S
G
G
Q
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
G
A
R
A
R
L
M
P
V
S
---------------
K
R
K
K
T
V
N
V
A
D
I
E
S
V
V
A
-
R
I
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
----------------------------------------------------------------------------------------------------------------------------------
D
R
L
K
M
L
V
------------------------------
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
K
A
L
-
G
I
E
--
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
G
F
D
Q
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
---------------------
N
S
T
D
A
M
E
E
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
N
E
L
L
F
G
S
L
V
D
G
G
Q
V
T
VA
L
D
K
E
K
N
--
E
L
---------
6
PsiBlast_PDB
64.85
96%
-72
- C2 -
3PXG
-
CLPC_BACSU
A:
[3-484]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
------
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
--
E
T
G
S
-----
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
-
Q
A
-
G
N
I
I
L
F
I
D
-------------
A
---------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
-
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
E
K
----------------------------------------------------------
Q
G
Q
E
N
S
------------------------------------------------------------
E
V
T
V
D
D
I
A
M
V
V
S
S
W
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
61.54
98%
-78
- C2 -
3PXG
-
CLPC_BACSU
A:
[3-406]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
------
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
--
E
T
G
S
-----
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
-
Q
A
-
G
N
I
I
L
F
I
D
A
----------------------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.72
57%
-100
- C1 -
4LJ7
2
CLPB_THET8
A:
[30-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
----
22
PsiBlast_CBE
58.59
57%
-100
- C1 -
4LJ7
2
CLPB_THET8
B:
[34-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
----
10
PsiBlast_PDB
58.51
57%
-98
- C1 -
4LJ5
1
A:
[4-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------------------------------------------------------------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
----
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
----
17
PsiBlast_PDB
58.39
56%
-96
- C1 -
4FCW
1
CLPB_THET8
A:
[16-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
A
R
V
-
12
PsiBlast_PDB
58.09
57%
-95
- C1 -
4LJ9
3
A:
[3-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
------------------------------------------------------------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
----
24
PsiBlast_CBE
58.01
57%
-94
- C1 -
4FD2
1
CLPB_THET8
B:
[13-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
A
R
V
-
102
HHSearch
57.95
59%
-95
- C1 -
4LJ9
3
A:
[6-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
-----
13
PsiBlast_PDB
57.66
57%
-97
- C1 -
4LJA
3
A:
[3-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
------------------------------------------------------------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
----
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
----
16
PsiBlast_PDB
57.65
56%
-93
- C1 -
4FCV
1
CLPB_THET8
A:
[16-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
A
R
V
-
21
PsiBlast_CBE
57.54
57%
-103
- C1 -
4LJ7
2
C:
[34-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
----
15
PsiBlast_PDB
57.47
57%
-94
- C1 -
4FD2
1
CLPB_THET8
A:
[13-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
A
R
V
-
23
PsiBlast_CBE
57.03
57%
-95
- C1 -
4FD2
1
D:
[13-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
--
V
D
V
G
P
A
--
G
L
V
F
A
V
P
A
R
V
-