@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00940: (2016-06-02 )
MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARPAIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVGALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSIDELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLGDQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVLVHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSSTNLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVITAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMNIILEDTAQGTRWKRGE
Atome Classification :
(20 SA)
.........10........20........--30........40...-.....50........60........70---.--.......80........90........100.......110......--.--..120.......130......-.----140.......150.....-..160..---------------------------------.------------------------------.--------.-.----------.------.170--.--------.------.---------------------------------------------------------------------.----------.-----...----.----------------------------180-.---.---------.-.---.-..-------------------------------------------.----------.-190-----------....---.----....200..-----.--------...-------------------------------------------.------------210---.-----------.------.----------------.--------------------..---------.----------------------.------.220----........230.......240....--.----------.-.250.......260.-----------------------------------------------.-------......270.......280-.-.-.....290...-.-.-..300.......310.--.--.--....320.......330.--.------.-------.---------...340.--.....-.350.......360.......370.......380.......----------390.......400.--------......410---------..---.---------...-----------.420.......430........440.......450.......460....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
I
T
L
YNTLTRQKET
F
V
PLEEG
K
V
K
M
Y
V
C--GP
T
V
Y
N
Y
I
H
IGNAR
P
-
A
I
V
Y
D
T
V
R
N
Y
L
E
YKGY
D
V
Q
Y
VSNFTD
V
---
D
--
D
K
L
I
K
A
A
N
E
LGEDV
P
T
I
S
E
R
F
I
K
A
Y
F
E
D
V
G
ALGCRKAD--L
H
P
R
V
M
--
E
--
N
M
D
A
I
I
E
F
V
D
Q
L
V
KKGYAYES-E----G
D
V
Y
F
K
T
RAFEGYG
K
L
S
Q
-
Q
S
I
D
-
E
L
---------------------------------R------------------------------S--------G-
A
----------
R
------
I
R----V--------G------E---------------------------------------------------------------------K----------K-----E
D
A
----
L
----------------------------
D
---
F
---
A
---------
L
-
W
---
K
-AA-------------------------------------------K----------E-G-------------EISW---D----SPWGKGRPG-----
W
--------
H
I
E
-------------------------------------------
C
------------
S
-----
A
-----------
M
------
V
----------------
K
--------------------
K
Y---------L----------------------G------D
Q
I
-----
D
I
HAGGQDLTFPHH
E
N
E
I
A
QSEALT--
G
----------
K
-
T
F
A
K
Y
W
LHN
G
Y
I
N
-I-----------------------------------------------
D
-------
N
E
K
M
S
K
S
LGN
F
V
L
V
H
D
I
I
K
-Q-H-
D
P
Q
L
L
R
F
F
M
L
S
-
V
-H-YRHPI
N
Y
S
E
E
L
L
E
N
T
K
--
S
--
A
--
F
S
R
L
K
T
A
Y
S
N
L
Q
H
R
LNSS--T------N-------L---------TED
D
D
Q
W
--
L
E
K
V
E
-
E
H
R
K
A
F
E
E
E
MDDDFN
T
A
N
A
I
S
V
L
F
D
L
A
K
HAN
Y
Y
L
QKDHT
A
D
----------
H
V
I
T
A
F
I
E
M
F
D
R
I
V
--------
S
V
LGFSL
G
E
---------
Q
E
---
L
---------
L
D
Q
-----------
E
I
E
D
L
I
E
K
R
N
E
A
R-RNRDF
A
L
S
D
Q
I
R
D
Q
L
K
SM
N
I
I
L
EDTAQGTRWKRGE
49
Fugue
97.21
45%
-81
- C3 -
1U0B
1
SYC_ECOLI
B:
[1-461]
-
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
G
M
Y
V
C
--
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
--
D
K
I
I
K
R
A
N
E
N
G
E
S
F
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
E
P
R
A
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
-
D
N---
G
D
V
M
F
D
V
P
T
D
P
T
Y
G
V
L
S
R
-
Q
D
L
D
-
Q
L
---------------------------------
Q
------------------------------
A
--------
G
-
A
----------
R
------
V
D
----
V
--------
V
------
D
---------------------------------------------------------------------
D
----------
K
-----
R
N
P
----
M
----------------------------
D
---
F
---
V
---------
L
-
W
---
K
-
M
S
-------------------------------------------
K
----------
E
-
G
-------------
E
P
S
W
---
P
----
S
P
W
G
A
G
R
P
G
-----
W
--------
H
I
E
-------------------------------------------
C
------------
S
-----
A
-----------
M
------
N
----------------
C
--------------------
K
Q
---------
L
----------------------
G
------
N
H
F
-----
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
--
D
----------
G
-
Q
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-------
R
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
-
Y
-
Y
-
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
-
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
--
L
E
R
L
Y
T
A
L
R
G
T
D
K
T
V
A
P
--------------------------------------
A
G
G
E
-
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
E
V
N
R
L
K
A
E
D
M
A
A
A
----------
N
A
M
A
S
H
L
R
K
L
S
A
V
L
GLLEQEPE
A
F
L
Q
S
G
A
Q
A
---------
D
D
---
S
---------
E
V
A
-----------
E
I
E
A
L
I
Q
Q
R
L
D
A
R
-
K
A
K
D
W
A
A
A
D
A
A
R
D
R
L
N
E
M
G
I
V
L
E
D
G
P
Q
G
T
T
W
R
R
K
-
3
PsiBlast_PDB
97.07
44%
-80
- C3 -
1U0B
1
SYC_ECOLI
B:
[2-460]
--
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
G
M
Y
V
C
--
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
--
D
K
I
I
K
R
A
N
E
N
G
E
S
F
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
E
P
R
A
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
-
D
N---
G
D
V
M
F
D
V
P
T
D
P
T
Y
G
V
L
S
R
-
Q
D
L
D
-
Q
L
---------------------------------
Q
------------------------------
A
--------
G
-
A
----------
R
------
V
D
----
V
--------
V
------
D
---------------------------------------------------------------------
D
----------
K
-----
R
N
P
----
M
----------------------------
D
---
F
---
V
---------
L
-
W
---
K
-
M
S
-------------------------------------------
K
----------
E
-
G
-------------
E
P
S
W
---
P
----
S
P
W
G
A
G
R
P
G
-----
W
--------
H
I
E
-------------------------------------------
C
------------
S
-----
A
-----------
M
------
N
----------------
C
--------------------
K
Q
---------
L
----------------------
G
------
N
H
F
-----
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
--
D
----------
G
-
Q
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-------
R
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
-
Y
-
Y
-
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
-
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
--
L
E
R
L
Y
T
A
L
R
G
T
D
K
T
V
A
P
A
--
G
------
G
------------------------------
E
-
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
E
V
N
R
L
K
A
E
D
M
A
A
A
----------
N
A
M
A
S
H
L
R
---
K
L
S
--------
A
V
L
G
L
L
E
Q
E
---------
P
E
---
A
---------
F
L
Q
SGAQADDSEVA
E
I
E
A
L
I
Q
Q
R
L
D
A
R
-
K
A
K
D
W
A
A
A
D
A
A
R
D
R
L
N
E
M
G
I
V
L
E
D
G
P
Q
G
T
T
W
R
R
--
50
Fugue
92.13
47%
-95
- C3 -
1LI5
1
SYC_ECOLI
A:
[1-402]
-
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
G
M
Y
V
C
--
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
--
D
K
I
I
K
R
A
N
E
N
G
E
S
F
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
E
P
R
A
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
-
D
N---
G
D
V
M
F
D
V
P
T
D
P
T
Y
G
V
L
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----------
K
-----
R
N
P
----
M
----------------------------
D
---
F
---
V
---------
L
-
W
---
K
-
M
S
-------------------------------------------
K
----------
E
-
G
-------------
E
P
S
W
---
P
----
S
P
W
G
A
G
R
P
G
-----
W
--------
H
I
E
-------------------------------------------
C
------------
S
-----
A
-----------
M
------
N
----------------
C
--------------------
K
Q
---------
L
----------------------
G
------
N
H
F
-----
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
--
D
----------
G
-
Q
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-------
R
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
-
Y
-
Y
-
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
-
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
--
L
E
R
L
Y
T
A
L
R
G
T
D
K
T
V
A
P
--------------------------------------
A
G
G
E
-
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
E
V
N
R
L
K
A
E
D
---
M
----------
A
A
A
N
A
M
A
S
H
L
R
K
L
S
--------
A
V
L
G
-------------------
L
---------
L
E
Q
-----------
E
P
E
A
F
L
-------------------------------------------
25
HHSearch
91.70
47%
-94
- C3 -
1LI5
1
SYC_ECOLI
A:
[1-402]
-
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
G
M
Y
V
C
--
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
--
D
K
I
I
K
R
A
N
E
N
G
E
S
F
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
E
P
R
A
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
D
N
----
G
D
V
M
F
D
V
P
T
D
P
T
Y
G
V
L
S
R
-
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
R
N
P
----
M
----------------------------
D
---
F
---
V
---------
L
-
W
---
K
-
M
S
-------------------------------------------
K
----------
E
-
G
-------------
E
P
S
W
---
P
----
S
P
W
G
A
G
R
P
G
-----
W
--------
H
I
E
-------------------------------------------
C
------------
S
-----
A
-----------
M
------
N
----------------
C
--------------------
K
Q
---------
L
----------------------
G
------
N
H
F
-----
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
--
D
----------
G
-
Q
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-------
R
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
-
Y
-
Y
-
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
-
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
--
L
E
R
L
Y
T
A
L
R
G
T
D
K
T
V
------------------------------------
A
--
P
A
G
G
E
-
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
E
V
N
R
L
K
A
E
D
M
A
-------------
A
A
N
A
M
A
S
H
L
R
K
L
S
--------
A
V
L
G
L
L
E
Q
E
---------
P
E
AFL-------------------------------------------------------------------------
22
PsiBlast_CBE
90.29
35%
-90
- C3 -
3SP1
3
SYC_BORBU
B:
[22-501]
M
I
L
K
L
Y
N
T
R
T
K
D
F
S
E
L
T
N
F
E
N
--
V
K
V
Y
A
C
--
G
P
T
V
Y
N
Y
A
H
I
G
N
F
R
T
-
Y
I
F
G
D
L
L
I
K
T
L
R
F
L
G
Y
K
V
N
Y
A
M
N
I
T
D
I
GH--------------
G
L
T
V
Y
E
I
S
E
F
F
T
E
A
F
F
N
D
C
R
K
L
N
I
V
Y
P
D
--
K
V
L
V
A
S
--
K
--
H
I
P
I
M
I
E
V
V
K
I
L
E
E
K
K
I
T
Y
F
S
-
N
----
G
N
V
Y
F
D
T
S
C
F
K
S
Y
G
E
M
A
G
I--------------------------------------------------------------------------------------------------------------------------
K
---------------------------------------------------------------------
F
----------
K
-----
R
N
K
----
T
----------------------------
D
---
F
---
V
---------
L
-
W
F
T
N
S
-
K
F
-------------------------------------------
K
----------
D
-
Q
-------------
E
M
K
W
---
D
----
S
P
W
G
F
G
Y
P
S
-----
W
--------
H
L
E
-------------------------------------------
C
------------
A
-----
A
-----------
M
------
N
----------------
L
--------------------
E
Y
---------
F
----------------------
K
------
D
A
L
-----
D
I
H
L
G
G
V
D
H
I
G
V
H
H
I
N
E
I
A
I
A
E
C
F
L
--
N
----------
K
-
K
W
C
D
V
F
V
H
G
E
F
L
I
-
M
-----------------------------------------------
D
-------
Y
N
K
M
S
-----
F
I
T
V
K
D
L
E
D
-
Q
-
N
F
S
P
L
D
F
R
Y
L
C
L
T
-
S
-
H
-
Y
R
N
Q
L
K
F
S
L
D
N
L
Q
A
S
K
--
I
--
A
--
R
E
N
L
I
N
K
L
S
Y
F
Y
E
S
L
D
P
V
D
L
N
------
T
-------
L
---------
N
K
D
L
K
N
F
--
G
F
S
V
E
K
E
Y
Y
D
S
F
V
E
K
I
S
F
D
L
N
V
A
Q
G
L
A
L
L
W
E
I
I
K
S
D
N
L
S
F
-----
V
S
----------
K
L
R
L
A
F
I
--
F
D
E
I
M
--------
S
L
---
N
L
R
E
---------
E
I
---
L
K
N
L
Q
N
HDVV
I
D
E
-----------
N
M
K
A
L
I
E
E
R
R
I
A
K
-
C
E
K
N
F
K
R
A
D
E
I
R
D
F
F
A
K
K
G
F
V
L
V
D
---
G
T
K
V
K
R
G
-
1
PsiBlast_PDB
90.07
44%
-88
- C3 -
1LI5
1
SYC_ECOLI
A:
[2-402]
--
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
G
M
Y
V
C
--
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
--
D
K
I
I
K
R
A
N
E
N
G
E
S
F
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
E
P
R
A
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
-
D
N---
G
D
V
M
F
D
V
P
T
D
P
T
Y
G
V
L
S
R
-
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
R
N
P
----
M
----------------------------
D
---
F
---
V
---------
L
-
W
---
K
-
M
S
-------------------------------------------
K
----------
E
-
G
-------------
E
P
S
W
---
P
----
S
P
W
G
A
G
R
P
G
-----
W
--------
H
I
E
-------------------------------------------
C
------------
S
-----
A
-----------
M
------
N
----------------
C
--------------------
K
Q
---------
L
----------------------
G
------
N
H
F
-----
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
--
D
----------
G
-
Q
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-------
R
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
-
Y
-
Y
-
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
-
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
--
L
E
R
L
Y
T
A
L
R
G
T
D
K
T
V
A
P
A
--
G
------
G
------------------------------
E
-
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
E
V
N
R
L
K
A
E
D
M
A
A
A
----------
N
A
M
A
S
H
L
R
---
K
L
S
--------
A
V
L
G
L
L
E
Q
E
---------
P
E
---
A
---------
F
L
-------------------------------------------------------------
2
PsiBlast_PDB
89.92
44%
-87
- C3 -
1LI7
2
SYC_ECOLI
A:
[2-402]
--
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
G
M
Y
V
C
--
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
--
D
K
I
I
K
R
A
N
E
N
G
E
S
F
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
E
P
R
A
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
-
D
N---
G
D
V
M
F
D
V
P
T
D
P
T
Y
G
V
L
S
R
-
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
R
N
P
----
M
----------------------------
D
---
F
---
V
---------
L
-
W
---
K
-
M
S
-------------------------------------------
K
----------
E
-
G
-------------
E
P
S
W
---
P
----
S
P
W
G
A
G
R
P
G
-----
W
--------
H
I
E
-------------------------------------------
C
------------
S
-----
A
-----------
M
------
N
----------------
C
--------------------
K
Q
---------
L
----------------------
G
------
N
H
F
-----
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
--
D
----------
G
-
Q
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-------
R
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
-
Y
-
Y
-
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
-
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
--
L
E
R
L
Y
T
A
L
R
G
T
D
K
T
V
A
P
A
--
G
------
G
------------------------------
E
-
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
E
V
N
R
L
K
A
E
D
M
A
A
A
----------
N
A
M
A
S
H
L
R
---
K
L
S
--------
A
V
L
G
L
L
E
Q
E
---------
P
E
---
A
---------
F
L
-------------------------------------------------------------
21
PsiBlast_CBE
86.73
44%
-88
- C3 -
1LI7
2
SYC_ECOLI
B:
[2-402]
--
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
G
M
Y
V
C
--
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
--
D
K
I
I
K
R
-----
E
S
F
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
E
P
R
A
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
-
D
N---
G
D
V
M
F
D
V
P
T
D
P
T
Y
G
V
L
S
R
-
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
P
----
M
----------------------------
D
---
F
---
V
---------
L
-
W
---
K
-
M
S
-------------------------------------------
K
----------
E
-
G
-------------
E
P
S
W
---
P
----
S
P
W
G
A
G
R
P
G
-----
W
--------
H
I
E
-------------------------------------------
C
------------
S
-----
A
-----------
M
------
N
----------------
C
--------------------
K
Q
---------
L
----------------------
G
------
N
H
F
-----
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
--
D
----------
G
-
Q
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-------
R
E
K
M
-----
N
F
F
T
V
R
D
V
L
K
-
Y
-
Y
-
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
-
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
--
L
E
R
L
Y
T
A
L
R
G
T
D
K
T
V
A
P
A
--
G
------
G
------------------------------
E
-
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
E
V
N
R
L
K
A
E
D
M
A
A
A
----------
N
A
M
A
S
H
L
R
---
K
L
S
--------
A
V
L
G
L
L
E
Q
E
---------
P
E
---
A
---------
F
L
-------------------------------------------------------------
4
PsiBlast_PDB
85.91
35%
-92
- C3 -
3SP1
2
SYC_BORBU
A:
[22-490]
M
I
L
K
L
Y
N
T
R
T
K
D
F
S
E
L
T
N
F
E
N
--
V
K
V
Y
A
C
--
G
P
T
V
Y
N
Y
A
H
I
G
N
F
R
T
-
Y
I
F
G
D
L
L
I
K
T
L
R
F
L
G
Y
K
V
N
Y
A
M
N
I
T
D
I
GHL--------------
L
T
V
Y
E
I
S
E
F
F
T
E
A
F
F
N
D
C
R
K
L
N
I
V
Y
P
D
--
K
V
L
V
A
S
--
K
--
H
I
P
I
M
I
E
V
V
K
I
L
E
E
K
K
I
T
Y
F
S
-
N
----
G
N
V
Y
F
D
T
S
C
F
K
S
Y
G
E
M
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
----------
K
-----
R
N
K
----
T
----------------------------
D
---
F
---
V
---------
L
-
W
F
T
N
S
-
K
------------------------------------------------------------------------
M
K
W
---
D
----
S
P
W
G
F
G
Y
P
S
-----
W
--------
H
L
E
-------------------------------------------
C
------------
A
-----
A
-----------
M
------
N
----------------
L
--------------------
E
Y
---------
F
----------------------
K
------
D
A
L
-----
D
I
H
L
G
G
V
D
H
I
G
V
H
H
I
N
E
I
A
I
A
E
C
F
L
--
N
----------
K
-
K
W
C
D
V
F
V
H
G
E
F
L
I
-
M
-----------------------------------------------
D
-----------------
F
I
T
V
K
D
L
E
D
-
Q
-
N
F
S
P
L
D
F
R
Y
L
C
L
T
-
S
-
H
-
Y
R
N
Q
L
K
F
S
L
D
N
L
Q
A
S
K
--
I
--
A
--
R
E
N
L
I
N
K
L
S
Y
F
Y
E
S
L
D
P
V
D
L
N
------
T
-------
L
---------
N
K
D
L
K
N
F
--
G
F
S
V
E
K
E
Y
Y
D
S
F
V
E
K
I
S
F
D
L
N
V
A
Q
G
L
A
L
L
W
E
I
I
K
S
D
N
L
S
F
-----
V
S
----------
K
L
R
L
A
F
I
--
F
D
E
I
M
--------
S
L
---
N
L
R
E
---------
E
I
---
L
K
N
L
Q
N
H
D
V
V
I
D
E
-----------
N
M
K
A
L
I
E
E
R
R
I
A
K
-
C
E
K
N
F
K
R
A
D
E
I
R
D
F
F
A
K
K
G
F
V
L
V
------------
27
HHSearch
84.01
35%
-87
- C3 -
3SP1
2
SYC_BORBU
A:
[22-490]
M
I
L
K
L
Y
N
T
R
T
K
D
F
S
E
L
T
N
F
--
E
N
V
K
V
Y
A
C
--
G
P
T
V
Y
N
Y
A
H
I
G
N
F
R
T
-
Y
I
F
G
D
L
L
I
K
T
L
R
F
L
G
Y
K
V
N
Y
A
M
N
I
T
D
I
---
G
HL-----------
L
T
V
Y
E
I
S
E
F
F
T
E
A
F
F
N
D
C
R
K
L
N
I
V
Y
P
D
--
K
V
L
V
A
S
--
K
--
H
I
P
I
M
I
E
V
V
K
I
L
E
E
K
K
I
T
Y
F
S
-
N
----
G
N
V
Y
F
D
T
S
C
F
K
S
Y
G
E
M
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
----------
K
-----
R
N
K
----
T
----------------------------
D
---
F
---
V
---------
L
-
W
---
F
-
T
N
-------------------------------------------
S
----------
K
----------------
M
K
W
---
D
----
S
P
W
G
F
G
Y
P
S
-----
W
--------
H
L
E
-------------------------------------------
C
------------
A
-----
A
-----------
M
------
N
----------------
L
--------------------
E
Y
---------
F
----------------------
K
------
D
A
L
-----
D
I
H
L
G
G
V
D
H
I
G
V
H
H
I
N
E
I
A
I
A
E
C
F
L
--
N
----------
K
-
K
W
C
D
V
F
V
H
G
E
F
L
I
-
M
-----------------------------------------------
D
-----------------
F
I
T
V
K
D
L
E
D
-
Q
N
F
-
S
P
L
D
F
R
Y
L
C
L
T
-
S
-
H
-
Y
R
N
Q
L
K
F
S
L
D
N
L
Q
A
S
K
--
I
--
A
--
R
E
N
L
I
N
K
L
S
Y
F
Y
E
S
L
D
P
V
--
D
------
L
-------
N
T
L
N
------
K
D
L
K
N
F
G
--
F
S
V
E
K
-
E
Y
Y
D
S
F
V
E
K
I
S
F
D
L
N
V
A
Q
G
L
A
L
L
W
E
I
I
K
S
D
N
L
S
F
V
S
K
L
--------------------
R
L
A
F
I
F
D
--------
E
I
M
S
L
N
L
R
E
E
I
L
K
N
L
Q
N
H
D
V
---
V
---------
I
D
E
-----------
N
M
K
A
L
I
E
E
R
R
I
A
K
-
C
E
K
N
F
K
R
A
D
E
I
R
D
F
F
A
K
K
G
F
V
L
V
------------
28
HHSearch
83.59
34%
-82
- C3 -
3C8Z
7
MSHC_MYCS2
A:
[20-413]
-
A
L
R
L
F
D
S
A
D
R
Q
V
R
P
V
T
P
G
--
P
T
A
T
M
Y
V
C
--
G
I
T
P
Y
D
A
T
H
L
G
H
A
A
T
-
Y
L
T
F
D
L
V
H
R
L
W
L
D
A
G
H
T
V
Q
Y
V
Q
N
V
T
D
V
---
D
--
D
P
L
F
E
R
A
E
R
D
G
I
D
W
R
T
L
G
D
R
E
T
Q
L
F
R
E
D
M
A
A
L
R
V
L
P
P
H
--
D
Y
V
A
A
T
--
D
--
A
I
A
E
V
V
E
M
V
E
K
L
L
A
S
G
A
A
Y
I
V
-
E
DAEY
P
D
V
Y
F
R
A
D
A
T
A
Q
F
G
Y
E
S
G
-
Y
D
R
D
-
T
M
---------------------------------
L
T
L
F
---------------------------
A
--------
E
-
R
----------
G
------
G
D
----
P
D-------
R
------
P
---------------------------------------------------------------------
G
----------
K
-----
S
D
Q
----
L
----------------------------
D
---
A
---
L
---------
L
-
W
---
R
-
A
E
-------------------------------------------
R
----------
P
-
G
-------------
E
P
S
W
---
P
----
S
P
F
G
R
G
R
P
G
-----
W
--------
H
V
E
-------------------------------------------
C
------------
S
-----
A
-----------
I
------
A
----------------
L
--------------------
T
R
---------
I
----------------------
G
------
T
G
L
-----
D
I
Q
G
G
G
S
D
L
I
F
P
H
H
E
Y
S
A
A
H
A
E
S
V
T
--
G
----------
E
R
R
F
A
R
H
Y
V
H
T
G
M
I
G
--------------------------------------------------------------------
V
L
V
S
Q
L
R
A
Q
G
-
V
-
D
P
S
A
I
R
L
G
L
F
S
-
G
-
H
-
Y
R
E
D
R
F
W
S
N
E
V
L
D
E
A
N
--
A
--
R
--
L
A
R
W
R
S
A
T
A
L
P
E
------------------------------------------
A
P
D
A
T
-
D
V
I
A
R
V
R
Q
Y
L
A
D
D
L
D
T
P
K
A
L
A
A
L
D
G
W
C
T
D
A
L
S
Y
G
G
H
D
T
----------------
E
S
P
R
L
V
A
T
T
V
D
--------
A
L
L
G
V
D
------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.09
33%
-77
- C3 -
3C8Z
7
MSHC_MYCS2
A:
[20-409]
-
A
L
R
L
F
D
S
A
D
R
Q
V
R
P
V
T
P
G
P
--
T
A
T
M
Y
V
C
--
G
I
T
P
Y
D
A
T
H
L
G
H
A
A
T
-
Y
L
T
F
D
L
V
H
R
L
W
L
D
A
G
H
T
V
Q
Y
V
Q
N
V
T
D
V
---
D
--
D
P
L
F
E
R
A
E
R
D
G
I
D
W
R
T
L
G
D
R
E
T
Q
L
F
R
E
D
M
A
A
L
R
V
L
P
P
H
--
D
Y
V
A
A
T
--
D
--
A
I
A
E
V
V
E
M
V
E
K
L
L
A
S
G
A
A
Y
I
V
-
E
DAEY
P
D
V
Y
F
R
A
D
A
T
A
Q
F
G
Y
E
S
G
-
Y
D
R
D
-
T
M
L
T
L
F
A
E
---------------------------
R
------------------------------
G
--------
G
-
D
----------
P
------
D
R
----
P
--------
G
---------------------------------------------------------------------------------------
K
-----
S
D
Q
----
L
----------------------------
D
---
A
---
L
---------
L
-
W
---
R
-
A
E
-------------------------------------------
R
----------
P
-
G
-------------
E
P
S
W
---
P
----
S
P
F
G
R
G
R
P
G
-----
W
--------
H
V
E
-------------------------------------------
C
------------
S
-----
A
-----------
I
------
A
----------------
L
--------------------
T
R
---------
I
----------------------
G
------
T
G
L
-----
D
I
Q
G
G
G
S
D
L
I
F
P
H
H
E
Y
S
A
A
H
A
E
S
V
T
--
G
E---------
R
-
R
F
A
R
H
Y
V
H
T
G
M
I
G
--------------------------------------------------------------------
V
L
V
S
Q
L
R
A
-
Q
-
G
V
D
P
S
A
I
R
L
G
L
F
S
-
G
-
H
-
Y
R
E
D
R
F
W
S
N
E
V
L
D
E
A
N
--
A
--
R
--
L
A
R
W
R
-----------
S
A
--
T
------
A
-------
L
---------
P
E
A
P
D
A
T
D
V
I
A
R
V
R
-
Q
Y
-------
L
A
D
D
L
D
T
P
K
A
L
A
A
L
D
G
W
C
T
D
A
L
S
Y
G
G
H
D
T
E
S
P
----------
R
L
V
A
T
T
V
D
A
L
------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.73
33%
-79
- C3 -
3C8Z
5
MSHC_MYCS2
B:
[20-409]
-
A
L
R
L
F
D
S
A
D
R
Q
V
R
P
V
T
P
G
P
--
T
A
T
M
Y
V
C
--
G
I
T
P
Y
D
A
T
H
L
G
H
A
A
T
-
Y
L
T
F
D
L
V
H
R
L
W
L
D
A
G
H
T
V
Q
Y
V
Q
N
V
T
D
V
---
D
--
D
P
L
F
E
R
A
E
R
D
G
I
D
W
R
T
L
G
D
R
E
T
Q
L
F
R
E
D
M
A
A
L
R
V
L
P
P
H
--
D
Y
V
A
A
T
--
D
--
A
I
A
E
V
V
E
M
V
E
K
L
L
A
S
G
A
A
Y
I
V
-
E
DAEY
P
D
V
Y
F
R
A
D
A
T
A
Q
F
G
Y
E
S
G
-
Y
D
R
D
-
T
M
L
T
L
F
A
E
---------------------------
R
------------------------------
G
--------
G
-
D
----------
P
------
D
R
----
P
--------
G
---------------------------------------------------------------------------------------
K
-----
S
D
Q
----
L
----------------------------
D
---
A
---
L
---------
L
-
W
---
R
-
A
E
-------------------------------------------
R
----------
P
-
G
-------------
E
P
S
W
---
P
----
S
P
F
G
R
G
R
P
G
-----
W
--------
H
V
E
-------------------------------------------
C
------------
S
-----
A
-----------
I
------
A
----------------
L
--------------------
T
R
---------
I
----------------------
G
------
T
G
L
-----
D
I
Q
G
G
G
S
D
L
I
F
P
H
H
E
Y
S
A
A
H
A
E
S
V
T
--
G
E---------
R
-
R
F
A
R
H
Y
V
H
T
G
M
I
G
--------------------------------------------------------------------
V
L
V
S
Q
L
R
A
-
Q
-
G
V
D
P
S
A
I
R
L
G
L
F
S
-
G
-
H
-
Y
R
E
D
R
F
W
S
N
E
V
L
D
E
A
N
--
A
--
R
--
L
A
R
W
R
-----------
S
A
--
T
------
A
-------
L
---------
P
E
A
P
D
A
T
D
V
I
A
R
V
R
-
Q
Y
-------
L
A
D
D
L
D
T
P
K
A
L
A
A
L
D
G
W
C
T
D
A
L
S
Y
G
G
H
D
T
E
S
P
----------
R
L
V
A
T
T
V
D
A
L
------------------------------------------------------------------------------------------------------------
34
HHSearch
70.29
19%
-78
- C3 -
4PY2
2
?
A:
[26-506]
----------------------
K
Y
Y
I
T
T
A
--
I
A
Y
P
N
G
K
P
H
I
G
H
A
Y
E
-
L
I
A
T
D
A
M
A
R
F
Q
R
L
N
G
M
D
V
Y
F
L
T
G
T
D
E
H
---
G
--
I
K
M
L
Q
S
A
R
K
E
G
I
T
P
R
D
L
A
D
R
N
T
S
A
F
R
R
M
A
E
V
L
N
S
S
-
N
D
--
D
Y
I
R
T
S
--
E
E
R
H
Y
K
A
S
Q
A
I
W
Q
A
M
V
A
N
G
D
I
Y
K
G
-
G
----
Y
A
G
W
Y
S
V
R
D
E
-
A
Y
--
Y
G
E
-
E
E
T
E
-
V
R
---------------------------------
A
DG
V
R
Y
G
P-----------------------
Q
--------
G
-
T
----------
P
------
V
E
----
W
V
E
E
E
S
Y
F
F
R
------
L
---------------------------------------------------------------------
S
AY
Q
D
K
L
L
D
L
Y
E
-----
N
N
P
---------------------------------
G
---
F
---
I
---------
M
-
P
---
A
-
E
R
-------------------------------------------
R
N
E
I
V
S
F
V
K
--
S
-
G
L
K
D
L
---------
S
I
S
R
---
T
T---
F
D
W
G
I
P
V
P
G
-----
D
--------
E
K
H
-------------------------------------------
V
M
Y
VWVDAL----
T
-----
N
-----------
Y
------
I
----------------
T
A
L
------------------
G
Y
PDTTDER--
W
A---------------------
Y
------
W
P
A
-----
N
A
H
I
I
G
K
D
I
S
R
F
H
A
V
Y
W
P
A
F
L
M
S
A
---
Q
----------
L
-
P
L
P
K
R
V
F
A
H
G
F
L
F
-
N
-----------------------------------------------
R
------------------
I
D
P
F
E
L
V
E
-
R
-
Y
-
G
L
D
Q
L
R
Y
F
L
M
R
-
E
V
P
-
F
G
Q
D
G
S
Y
S
H
E
A
I
V
N
R
T
N
A
D
--
L
--
A
N
D
L
G
N
L
A
Q
R
S
L
S
M
I
A
K
N
--
C
------
E
-------
G
KVPQPGAF-
S
E
A
D
K
A
I
--
L
D
Q
A
D
-
A
A
L
E
T
A
R
K
A
M
D
-
D
Q
A
L
H
L
A
L
G
A
I
F
A
V
V
A
E
A
N
R
Y
F
A
G
Q
E
P
W
A
LRKTD
P
----
A
R
M
G
T
V
L
Y
V
T
A
E
V
L
--------
R
R
V
G
I
M
V
Q
P
--------------
F
---------
I
P
Q
-----------
S
A
E
K
L
L
D
I
L
A
V
P
A
-
D
K
R
Q
F
A
-----------------------------
30
HHSearch
69.40
19%
-74
* C3 *
4QRE
4
?
A:
[29-517]
---------------------
A
K
E
T
F
Y
I
T
T
P
I
Y
Y
P
S
G
N
L
H
I
G
H
A
Y
S
-
T
V
A
G
D
V
I
A
R
Y
K
R
M
Q
G
Y
D
V
R
Y
L
T
G
T
D
E
H
---
G
--
Q
K
I
Q
E
K
A
Q
K
A
G
K
T
E
I
E
Y
L
D
E
M
I
A
G
I
K
Q
L
W
A
K
L
E
I
S
N
-
D
--
D
F
I
R
T
T
--
E
E
R
H
K
H
V
V
E
Q
V
F
E
R
L
L
K
Q
G
D
I
Y
L
G
-
E
----
Y
E
G
W
Y
S
V
P
D
E
-
T
Y
--
Y
T
E
-
S
Q
L
V
-
D
P
Q
Y
E
NGKIIGGKSP--------------------
D
------------------------------
S
--------
G
-
H
----------
E
------
V
E
--------------------
L
---------------------------------------------------------------------
V
----------
K
-----
E
E
S
----
Y
----------------------------
F
---
F
---
N
---------
I
-
S
---
K
-
Y
T
D
R
L
L
E
F
Y
D
Q
N
PDFIQPP
S
R
K
N
E
M
I
N
NF----------------
I
----------
K
P
G
LADL---------
A
V
S
R
---
T
S---
F
N
W
G
V
H
V
P
S
-----
N
PKH-----
V
V
Y
-------------------------------------------
V
------------
W
IDALV
N
-----------
Y
I
S
----
A
----------------
L
--------------------
G
Y
---------
L
SDDE
S
L
F
N
K
-------------
Y
------
W
P
A
-----
D
I
H
L
M
A
K
E
I
V
R
F
H
S
I
I
W
P
I
L
L
M
A
L
---
D
----------
L
-
P
L
P
K
K
V
F
A
H
G
W
I
L
-
M
-----------------------------------------------
K
-------
D
G
K
M
S
K
S
K
G
N
V
V
D
P
N
I
L
I
D
-
R
-
Y
-
G
L
D
A
T
R
Y
Y
L
M
R
-
E
L
P
-
F
G
S
D
G
V
F
T
P
E
A
F
V
E
R
T
--
N
F
D
L
--
A
N
D
L
G
N
L
V
N
R
T
I
S
M
V
N
K
Y
--
F
------
D
-------
G
E
L
P
A
Y
QGPL
H
E
L
D
E
E
M
--
E
A
M
A
L
-
E
T
V
K
S
Y
T
E
S
M
E
-
S
L
Q
F
S
V
A
L
S
T
V
W
K
F
I
S
R
T
N
K
Y
I
D
E
T
T
P
W
V
L
A
K
D
DSQ
K
--
D
M
L
G
N
V
M
A
H
L
V
E
N
I
--------
R
Y
A
A
V
L
L
R
P
--------------
F
---------
L
T
H
-----------
A
P
K
E
I
F
E
Q
L
N
I
N
N
------------------------------------
45
HHSearch
69.03
18%
-79
- C3 -
2V0C
10
?
A:
[34-809]
----------------------
K
Q
Y
V
L
V
M
--
F
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
-
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
---
G
--
L
P
A
E
N
A
A
L
K
F
G
V
H
P
K
D
W
T
Y
A
N
I
R
Q
A
K
E
S
L
R
L
M
G
I
L
Y
-
D
WD
R
E
V
T
T
C
E
P
E
--
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
-
K
----
G
L
V
N
W
C
P
K
C
Q
-
T
V
--
L
A
N
-
E
Q
V
V
-
E
G
RCWRHED
T
P
V
E
K
R
E
L
E
Q
W
Y
L
RITAY
A
E
R
L
L
K
D
L
E
GLNWP
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
EG
K
--------
E
-
V
R
I
P
V
F
T
TRPD
T
LFGAT
F
L
V
----
L
A
P------
E
HP----
L
TLELAAPEK
R
E
E
V
L
A
Y
V
E
A
A
K
R
KT
E
I
E
R
Q
AEGRE
K
T
G
V
F
LG
A
Y
A
L
NPATG
E
R
I
P
I
W
T
A
DYVLFGYGTG
A
I
----------
M
-----
A
V
P
AHD
Q
R
----------------------------
D
---
Y
---
E
---------
F
-
A
---
R
-
K
F
G
L
P
I
K
K
V
I
E
R
P
GEPLPEPLERAYE
E
P
G
I
M
V
NSGPFDGTE
S
E
E
G
K
R
K
V
I
A
W
L
E
E
-
K
-
G
L
G
K
G
R
V
T
Y
RLRDW
L
I
S
R
---
Q
----
R
Y
W
G
T
P
I
P
M
-----
V
--------
H
C
E
AC
G
V
V
P
V
P
EEELPVLLPDLKDVEDIRPKGKSPLEAHPEFY
E
T
T
C
------------
P
-----
K
CG
G
P
A
K
R
DT
D
T
M
D
T
F
F
D
S
S
----------------
W
Y
Y
L
R
Y
T
D
PHNDRLPFD
P
E
K
A
N
A
---------
W
-----------------------------
M
P
V
-----
D
Q
Y
I
G
G
V
E
H
A
V
L
H
L
L
Y
S
R
F
F
T
K
F
L
H
D
L
G
MVKV------
E
-
E
P
F
Q
G
L
F
T
Q
G
M
V
L
-
A
WTDF
G
P
V
E
V
E
GS
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
E
D
G
T
L
H
L
W
K
P
A
V
M
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
-
E
-
Q
-
G
A
D
I
A
R
I
T
I
L
F
-
A
A
P
-
P
E
N
E
M
V
W
T
E
E
G
V
Q
G
A
W
--
R
--
F
--
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
E
T
--
S
GVFQAE
A
-------
L
---------
E
G
K
D
R
E
L
--
Y
G
K
L
H
-
E
T
L
K
K
V
T
E
D
L
E
-
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
N
A
L
Y
E
Y
R
K
D
R
P
V
------------------
T
P
V
Y
R
T
A
I
--------
R
Y
Y
L
Q
M
L
F
P
--------------
F
---------
A
P
H
-----------
L
A
E
E
L
W
H
W
F
W
P
D
S
L
F
E
A
G
W
P
E
L
D
E
-------------------------
37
HHSearch
64.64
18%
-63
- C3 -
2D5B
1
SYM_THET8
A:
[8-470]
--------------------------
T
T
P
--
I
Y
Y
V
N
A
E
P
H
L
G
H
A
Y
T
-
T
V
V
A
D
F
L
A
R
W
H
R
L
D
G
Y
R
T
F
F
L
T
G
T
D
E
H
---
G
--
E
T
V
Y
R
A
A
Q
A
A
G
E
D
P
K
A
F
V
D
R
V
S
G
R
F
K
R
A
W
D
L
L
G
I
A
Y
-
D
--
D
F
I
R
T
T
--
E
E
R
H
K
K
V
V
Q
L
V
L
K
K
V
Y
E
A
G
D
I
Y
Y
G
-
E
----
Y
E
G
L
Y
C
V
S
C
E
-
R
F
--
Y
T
E
-
K
E
L
V
E
G
L
---------------------------------
C
PI----------------------------
H
--------
G
-
R
----------
P
------
V
E
----
R
R
K
E
G
N
Y
F
F
R
------
M
---------------------------------------------------------------------
E
KY
R
P
W
L
Q
E
Y
I
Q
E
N
PDL
I
R
P
----
E
----------------------------
G
Y
R
N
E
---
V
---------
L
A
M
---
L
-
A
E
-------------------------------------------
P
----------
I
-
G
DL-----------
S
I
S
R
PKS
R
----
V
P
W
G
I
P
L
P
W
DE---
N
--------
H
V
T
-------------------------------------------
F
------------
V
-----
W
-----------
F
D
A
----
L
----------------
L
--------------------
N
Y
---------
V
S
A
L
DYPE---------------
G
E
A
Y
R
T
F
W
P
H
-----
A
W
H
L
I
G
K
D
I
L
K
P
H
A
V
F
W
P
T
M
L
K
A
A
---
G
----------
I
-
P
M
Y
R
H
L
N
V
G
G
F
L
L
G
P
-----------------------------------------------
D
-------
G
R
K
M
S
K
T
L
G
N
V
V
D
P
F
A
L
L
E
-
K
-
Y
-
G
R
D
A
L
R
Y
Y
L
L
R
-
E
I
P
-
Y
G
Q
D
T
P
V
S
E
E
A
L
R
T
R
Y
--
E
A
D
L
--
A
D
D
L
G
N
L
V
Q
R
T
R
A
M
L
F
R
F
--
A
------
E
-------
G
RIP------
E
P
V
A
G
E
E
--
L
A
E
G
T
-
G
L
A
G
R
L
R
P
L
V
R
-
E
L
K
F
H
V
A
L
E
E
A
M
A
Y
V
K
A
L
N
R
Y
I
N
E
K
K
P
W
E
L
F
K
K
E
P
----
E
E
A
R
A
V
L
Y
R
V
V
E
G
L
--------
R
I
A
S
I
L
L
T
P
--------------
A
---------
M
P
D
-----------
K
M
A
E
L
R
R
A
L
G
L
K
-------------------------------------
31
HHSearch
64.27
15%
-70
- C3 -
3KFL
14
?
A:
[31-518]
--------------------------
T
T
P
--
I
Y
Y
V
N
A
S
P
H
I
G
H
V
Y
S
-
T
L
I
V
D
V
L
G
R
Y
H
R
V
K
G
E
E
V
F
V
M
T
G
T
D
E
H
---
G
--
Q
K
V
A
E
A
A
A
K
Q
G
V
S
P
M
D
F
T
T
S
V
S
S
E
F
K
Q
C
F
Q
E
M
N
Y
D
-
M
N
--
Y
F
I
R
T
T
--
N
P
T
H
E
K
L
V
Q
D
I
W
K
K
L
A
A
K
G
D
I
Y
L
G
-
K
----
Y
E
G
W
Y
S
V
S
D
E
-
S
F
--
L
T
A
-
Q
N
V
A
-
D
G
---------------------------------
V
D
RDG
K
P
C
K
V
S
LE------------------
S
--------
G
-
H
----------
V
------
V
T
----
W
--------
V
E
E
E
N
Y
M
F
---------------------------------------------------------------------
R
----------
L
-----
S
A
F
----
R
----------------------------
E
---
R
---
L
L
K
Y
F
H
D
H
P
N
C
-
I
---
V
-
P
E
-------------------------------------------
F
R
R
R
E
V
I
K
T
V
E
K
-
G
LFDL---------
S
I
S
R
---
K
RESV
M
N
W
S
I
P
V
P
G
DERHC
I
--------
Y
V
W
-------------------------------------------
L
------------
D
-----
A
-----------
L
------
F
----------------
N
--------------------
Y
Y
---------
T
G
A
L
T
R
V
A
TDG
T
E
T
L
D
EDHHALN
R
------
W
P
A
-----
D
V
H
V
V
G
K
D
I
L
K
F
H
A
I
Y
W
P
A
F
L
M
S
A
---
E
----------
L
-
P
L
P
E
R
L
V
S
H
G
W
W
T
-
K
-----------------------------------------------
D
-------
H
K
K
I
S
K
S
L
G
N
A
F
D
P
V
E
K
A
K
-
E
-
F
-
G
I
D
A
L
K
Y
F
L
M
R
E
S
-
N
-
F
Q
D
D
G
D
Y
S
D
K
N
M
V
A
R
L
--
N
G
E
L
--
A
D
T
L
G
N
L
V
S
R
C
V
A
P
K
I
N
V
--
N
------
G
MW
P
E
P
A
E
Y
---------
S
E
S
D
K
T
L
--
I
A
S
L
N
-
N
L
A
G
T
V
D
H
Y
Y
C
-
L
P
D
I
Q
H
A
L
I
A
I
F
D
V
L
R
S
L
N
A
Y
V
T
E
N
A
P
W
K
LVKMD
T
----
A
R
L
G
T
V
L
Y
V
T
M
E
G
L
--------
R
I
C
T
M
F
L
Q
P
--------------
V
---------
M
P
Q
-----------
K
A
K
E
I
M
D
A
L
G
V
P
E
-
A
----------------------------------
36
HHSearch
63.75
17%
-74
- C3 -
2X1L
4
?
A:
[13-498]
----------------------
P
F
Y
I
T
T
A
--
I
A
Y
P
N
G
V
P
H
I
G
H
A
Y
E
-
Y
I
A
T
D
A
I
A
R
F
K
R
L
D
G
Y
D
V
R
Y
L
T
G
T
D
V
H
---
G
--
Q
K
M
A
E
T
A
A
K
E
G
I
P
A
A
E
L
A
R
R
N
S
D
V
F
Q
R
L
Q
E
K
L
N
I
S
-
F
D
--
R
F
I
R
T
S
D
A
D
--
H
Y
E
A
S
K
A
I
W
K
R
M
A
D
A
G
D
I
Y
L
D
-
A
----
Y
K
G
W
Y
S
I
R
D
E
-
R
F
--
F
T
E
-
N
E
T
T
-
E
Q
---------------------------------
P
DG
T
R
I
A
TE----------------------
T
--------
G
-
A
----------
P
------
V
T
----
W
T
E
E
Q
T
Y
F
F
R
LSA---
Y
---------------------------------------------------------------------
T
D
R
--------
L
-----
L
A
L
----
Y
----------------------------
E
---
E
---
H
P--------
E
-
F
---
I
G
P
D
A
------------------------------------------
R
R
N
E
I
V
S
F
V
S
-
G
-
G
LKDL---------
S
I
S
R
---
T
T---
F
D
W
G
V
P
V
P
D
-----
H
PDHVMY
V
W
V
D
A
-------------------------------------------
L
------------
T
-----
N
-----------
Y
------
L
----------------
T
--------------------
G
V
GFPDTES
E
S
F
R
R
--------------------
Y
------
W
P
A
-----
D
L
H
M
I
G
K
D
I
I
R
F
H
T
V
Y
W
P
A
F
L
M
S
A
---
G
----------
L
-
P
L
P
K
R
I
F
A
H
G
W
L
L
-
N
-----------------------------------------------
R
-------
G
E
K
M
S
K
S
I
G
N
V
V
D
P
V
N
L
V
D
-
T
-
F
-
G
L
D
Q
V
R
Y
F
L
L
R
-
E
-
V
P
F
G
Q
D
G
S
Y
N
E
D
A
I
I
G
R
V
--
N
AD
L
--
A
N
E
L
G
N
L
A
Q
R
S
L
S
M
V
A
K
N
--
L
------
G
-------
A
A
V
P
D
P
G
E
F-
T
D
E
D
T
A
L
--
L
A
A
A
D
-
A
L
L
E
R
V
R
E
H
F
D
-
V
P
A
M
H
L
A
L
E
A
I
W
S
V
L
G
A
A
N
R
Y
F
S
A
Q
E
P
W
V
L
R
K
SDA
A
E
D
Q
Q
R
F
R
T
V
L
Y
T
T
L
E
V
V
--------
R
I
A
S
L
L
L
Q
P
--------------
V
---------
M
P
E
-----------
S
T
A
K
L
L
D
L
L
G
Q
P
T
-
D
E
R
D
F
------------------------------
29
HHSearch
63.59
19%
-73
- C3 -
1RQG
2
SYM_PYRAB
A:
[4-522]
-----------------------
Y
M
V
T
S
A
--
L
P
Y
A
N
G
P
I
H
A
G
H
L
A
G
A
Y
L
P
A
D
I
F
V
R
Y
L
R
L
K
G
E
D
V
V
F
I
C
G
T
D
E
H
---
G
--
T
P
I
S
F
R
A
L
K
E
G
R
S
P
R
E
I
V
D
E
F
H
E
Q
I
K
I
T
F
Q
R
A
K
I
S
-
F
D
--
F
F
G
R
T
E
L
P
I
--
H
Y
K
L
S
Q
E
F
F
L
K
A
Y
E
N
G
H
L
V
K
K
-
V
----
T
K
Q
A
Y
C
E
H
D
K
-
M
F
--
L
P
D
-
R
F
V
I
-
G
T
---------------------------------
C
------------------------------
P
Y
C
G
A
E
D
QK
G
D
Q
----------
C
------
E
V
CGRP
L
--------
T
P-----
E
---------------------------------------------------------------------
I
----------
L
-----
I
N
P
----
R
CAICGRP
I
S
F
R
D
S
A
H
Y
Y
I
KMQDF
A
E
R
L
K
R
---
W
I
E
K
Q
---------
P
-
W
---
K
-
P
N
-------------------------------------------
V
K
N
M
V
L
S
W
I
E-
E
-
G
LEER---------
A
I
T
R
---
D
----
L
N
W
G
I
P
V
P
L
-----
D
--------
E
E
D
-------------------------------------------
M
KGKVLYVWFE
A
P
I
-----
G
-----------
Y
------
I
S
I
T
I
E
H
F
K
R
I
GKPNEW
K
--------------------
K
Y
---------
W
-----------------------------
L
N
I
D
G
Q
T
R
V
I
H
F
I
G
K
D
N
I
P
F
H
A
I
F
W
P
A
F
L
M
A
Y
---
G
K
Y
K
D
EEVE
A
E
W
-
N
L
P
Y
D
I
P
A
N
E
Y
L
T
-
L
-----------------------------------------------
E
-------
G
K
K
F
S
T
S
R
N
W
A
I
W
V
H
E
F
L
D
-
V
-
F
-
P
A
D
Y
L
R
Y
Y
L
T
T
-
I
-
M
P
E
T
R
D
S
D
F
S
F
S
D
F
K
V
R
I
--
N
--
E
EL
V
N
N
L
G
N
F
V
H
R
A
L
T
F
V
N
R
Y
--
F
------
D
-------
G
V
V
P
E
R
G
E
L-
D
E
L
D
R
E
A
--
L
E
E
I
E
-
K
A
F
K
E
V
G
E
L
I
M
-
N
Y
R
F
K
D
A
L
K
R
V
M
S
L
A
S
F
G
N
R
Y
F
D
H
K
Q
P
W
K
T
A
K
ED
K
----
V
R
T
G
T
T
V
N
I
S
L
Q
I
V
--------
K
A
L
G
I
L
L
E
P
--------------
F
---------
L
P
D
-----------
A
S
E
K
I
W
H
L
L
N
L
D
-------------------------------------