@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu01120: (2016-06-02 )
MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAHAIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAVCELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLDYLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTLDSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEKDLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIISGMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHVWIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLFDGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITSRRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVAEEIIKKNKGE
Atome Classification :
(20 SA)
--------.........10........20........30........40........50........60........70...-------.....80........90........100.......110.......120.......130.......140.......150.......160.......170.--------------------......180..-....-.190....----------------...200.......210.......220.......230.......240...---....250.......260..--.....270.......280..-.....290-----.....-...300.......310.......320-.......330.......340....---------...350.......360.......370.......380-.......390-..-..--....400----.-.......410.......420.......430.......440.......450.......460......-.470.......480.......490........500.......510.......---520..-----------------------------------------.....530.----......540.......550.......560.......570-........580.......590.......600.......610.......620.......630.....--..640.......650.......660.......670......------.680.......690-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MAREFSLEKTRNI
G
I
M
A
H
IDAGKTTT
T
E
R
I
L
F
YTG
R
I
H
KIGETHEG
A
S
Q
M
D
W
M
E
Q
E
Q
ER
G
I
T
I
T
SAATT
A
Q
WK
G
-------
Y
R
V
N
I
I
DTPG
H
V
D
F
T
V
E
V
E
RS
L
R
V
LD
G
A
V
A
V
L
DAQSGVEP
Q
T
E
T
V
W
R
QATTYGV
P
R
I
V
F
V
N
K
M
D
K
I
G
A
D
F
L
Y
S
V
G
T
L
R
D
R
L
QANA
H
A
I
QLPIGAED
N
F
E
--------------------
G
I
I
D
L
V
E
N
V
A
Y
-
F
Y
ED-DLGTR
S
D
A
----------------
K
E
I
P
E
E
Y
K
E
Q
A
E
E
L
R
N
S
L
I
E
A
V
C
E
L
D
E
E
L
M
D
K
YLEGEEI
T
I
D
E
L
K
A
G
I
R---KG
T
L
N
V
E
F
Y
P
V
LVGSAFKN--K
G
V
Q
L
V
L
D
A
V
L
D
YLPAPT
D
V
-
A
AIKGTR------PD
T
N
E
-
E
I
E
RHSSDEE
P
F
S
A
L
A
F
K
VMTDPYV
G
-
K
L
T
F
F
R
V
YSGTLDSGSYVKNSTKG---------
K
R
E
R
V
G
R
I
L
Q
M
HAN
S
R
E
E
I
S
T
VYAG
D
I
A
A
AVGLKDT-TTGDTLCD-E-K
D
-
L
V
--
I
L
ESME-----F-PEP
V
I
D
V
A
IEPKSKA
D
Q
D
K
M
G
I
A
L
A
K
LAEEDPTFRTQTNPET
G
Q
T
I
I
S
G
M
G
E
L
H
L
D
I
I
V
D
R
M
K
R
E
F
-
K
V
E
ANVGA
P
Q
V
A
Y
R
E
T
FRTGAK-
V
E
G
K
F
V
RQSGGRGQF
G
H
V
W
I
E
FEPNEEGA---GFEFE-----------------------------------------NAIVGGVV
P
----
R
E
Y
I
P
A
V
Q
A
G
L
E
D
A
L
ENGVLAGF
P
L
I
D
I
K
A
K
LFDGSYH--DVDSN
E
M
A
F
K
V
A
A
S
M
A
L
K
N
A
V
S
KCN
P
V
L
L
EP
I
M
K
V
E
V
V
I
P
E
E
Y
M
G
D
I
M
G
D
I
T
SRRGRVEGMEARG
N
--
A
Q
V
V
R
A
M
V
P
L
A
E
M
F
G
Y
A
T
A
LRSNTQGR
G
T
F
T
M
H
M
D
H
Y
E
E
V
P
------
K
S
V
A
E
E
I
I
KKNKGE-----------------
21
PsiBlast_CBE
89.88
78%
-15
- C- -
2XEX
2
EFG_STAAU
B:
[2-693]
---------
A
R
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
G
----
G
A
S
Q
M
D
W
M
E
Q
E
--------
S
A
A
T
T
A
A
W
E
G
-------
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
F
E
Y
S
V
S
T
L
H
D
R
L
Q
A
N
A
A
P
I
Q
L
P
I
G
A
E
D
E
F
E
--------------------
A
I
I
D
L
V
E
M
K
C
F
-
K
Y
T
N
-
D
L
G
T
E
I
E
E
----------------
I
E
I
P
E
D
H
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
---
Q
A
T
T
N
V
E
F
Y
P
V
L
C
G
T
A
F
K
N
--
K
G
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
V
-
K
P
I
I
G
H
R
A-----
S
N
P
E
E
-
E
V
I
A
K
A
D
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
P
Y
V
G
-
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
---------
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
V
G
L
K
D
T
-
G
T
G
D
T
L
C
G
-
E
-
K
N
-
D
I
--
I
L
E
S
M
E
-----
F
-
P
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
-----
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
-
N
V
E
C
N
V
G
A
P
M
V
S
Y
R
E
T
F
K
S
S
A
Q
-
V
Q
G
K
F
S
R
Q
S
G
G
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
T
G
A
---
G
F
E
F
E
-----------------------------------------
N
A
I
V
G
G
V
V
P
----
R
E
Y
I
P
S
V
E
A
G
L
K
D
A
M
E
N
G
V
L
A
G
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
--
D
V
D
S
S
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
R
V
D
G
M
E
P
R
G
N
--
A
Q
V
V
N
A
Y
V
P
L
S
E
M
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
------
K
S
I
A
E
D
I
I
K
K
N
K
G
E
-----------------
130
Fugue
89.84
66%
-87
- C4 -
4M1K
2
?
A:
[6-688]
-----------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
-
D
A
P
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
L
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
-----------------------
7
PsiBlast_PDB
89.50
66%
-86
- C4 -
4M1K
2
?
A:
[6-688]
-----------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
L
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
-----------------------
12
PsiBlast_PDB
89.12
66%
-84
- C4 -
2BM0
2
?
A:
[6-689]
-----------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
A
--------------------
T
I
T
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
K
----------------------
1
PsiBlast_PDB
88.29
78%
-15
- C- -
2XEX
2
EFG_STAAU
A:
[2-693]
---------
A
R
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
-------------------------
T
S
A
A
T
T
A
A
W
E
G
-------
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
F
E
Y
S
V
S
T
L
H
D
R
L
Q
A
N
A
A
P
I
Q
L
P
I
G
A
E
D
E
F
E
--------------------
A
I
I
D
L
V
E
M
K
C
F
-
K
Y
T
N
-
D
L
G
T
E
I
E
E
----------------
I
E
I
P
E
D
H
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
---
Q
A
T
T
N
V
E
F
Y
P
V
L
C
G
T
A
F
K
N
--
K
G
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
V
-
K
P
I
I
G
H
R
A-----
S
N
P
E
E
-
E
V
I
A
K
A
D
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
P
Y
V
G
-
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
---------
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
V
G
L
K
D
T
-
G
T
G
D
T
L
C
G
-
E
-
K
N
-
D
I
--
I
L
E
S
M
E
-----
F
-
P
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
---
T
G
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
-
N
V
E
C
N
V
G
A
P
M
V
S
Y
R
E
T
F
K
S
S
A
Q
-
V
Q
G
K
F
S
R
Q
S
G
G
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
T
G
A
---
G
F
E
F
E
-----------------------------------------
N
A
I
V
G
G
V
V
P
----
R
E
Y
I
P
S
V
E
A
G
L
K
D
A
M
E
N
G
V
L
A
G
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
--
D
V
D
S
S
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
R
V
D
G
M
E
P
R
G
N
--
A
Q
V
V
N
A
Y
V
P
L
S
E
M
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
------
K
S
I
A
E
D
I
I
K
K
N
K
G
E
-----------------
3
PsiBlast_PDB
88.23
66%
-80
- C4 -
2J7K
2
EFG_THETH
A:
[6-688]
-----------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
------------------------
I
T
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
-----------------------
9
PsiBlast_PDB
88.13
66%
-81
- C4 -
1FNM
2
EFG_THETH
A:
[6-688]
-----------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
A
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
-----------------------
2
PsiBlast_PDB
87.86
66%
-79
- C5 -
2OM7
-
?
L:
[6-688]
-----------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
-----------------------
8
PsiBlast_PDB
87.68
66%
-82
- C4 -
4MYU
2
EFG_THETH
A:
[6-688]
-----------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
K
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
-----------------------
104
HHSearch
87.40
78%
-14
- C- -
2XEX
2
EFG_STAAU
A:
[2-693]
---------
A
R
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
-------------------------
T
S
A
A
T
T
A
A
W
E
G
-------
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
F
E
Y
S
V
S
T
L
H
D
R
L
Q
A
N
A
A
P
I
Q
L
P
I
G
A
E
D
E
F
E
--------------------
A
I
I
D
L
V
E
M
K
C
F
K
Y
T
N
D
-
L
-
G
T
E
I
E
E
----------------
I
E
I
P
E
D
H
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
---
Q
A
T
T
N
V
E
F
Y
P
V
L
C
G
T
A
F
K
N
--
K
G
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
V
K
P
I
I
G
H
R
A
------
S
N
P
E
E
-
E
V
I
A
K
A
D
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
P
Y
V
G
-
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
---------
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
V
G
L
K
D
T
-
G
T
G
D
T
L
C
G
-
E
-
K
N
-
D
I
--
I
L
E
S
M
E
-----
F
-
P
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
---
T
G
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
-
N
V
E
C
N
V
G
A
P
M
V
S
Y
R
E
T
F
K
S
S
A
Q
-
V
Q
G
K
F
S
R
Q
S
G
G
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
T
G
A
---
G
F
E
F
E
-----------------------------------------
N
A
I
V
G
G
V
V
P
----
R
E
Y
I
P
S
V
E
A
G
L
K
D
A
M
E
N
G
V
L
A
G
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
--
D
V
D
S
S
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
R
V
D
G
M
E
P
R
G
N
--
A
Q
V
V
N
A
Y
V
P
L
S
E
M
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
------
K
S
I
A
E
D
I
I
K
K
N
K
G
E
-----------------
11
PsiBlast_PDB
86.74
66%
-81
- C4 -
2BM1
2
EFG_THETH
A:
[6-688]
-----------
E
Y
D
L
K
R
L
R
N
I
V
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
-------------------------
I
T
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
-----------------------
6
PsiBlast_PDB
85.64
66%
-75
- C4 -
4MYT
2
EFG_THETH
A:
[6-688]
-----------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
--
E
V
D
S
S
A
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
-----------------------
13
PsiBlast_PDB
83.95
66%
-68
- C5 -
3IZP
-
?
E:
[6-688]
-----------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
G
E
V
H
E
G
A
A
T
M
D
F
M
E
Q
E
R
E
R
G
I
T
I
T
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
I
E
-----
V
-
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
A
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
-----------------------
132
Fugue
82.27
65%
-79
- C4 -
1ELO
-
?
?:
[5-689]
----------
V
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
-
D
A
-
P
R
--
V
I
L
--------------
I
D
V
A
I
E
P
K
S
Q
A
--------
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
Q
T
---
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
------
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
K
----------------------
15
PsiBlast_PDB
82.03
61%
-65
- C5 -
3J0E
2
EFG_ECOLI
H:
[1-699]
---------
A
R
T
T
P
I
A
R
Y
R
N
I
G
I
S
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
F
Y
T
G
V
N
H
K
I
G
E
V
H
D
G
A
A
T
M
D
W
M
E
Q
E
Q
E
R
G
I
T
I
T
S
A
A
T
T
A
F
W
S
G
MAKQYEP
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
V
M
V
Y
C
A
V
G
G
V
Q
P
Q
S
E
T
V
W
R
Q
A
N
K
Y
K
V
P
R
I
A
F
V
N
K
M
D
R
M
G
A
N
F
L
K
V
V
N
Q
I
K
T
R
L
G
A
N
P
V
P
L
Q
L
A
I
G
A
E
E
H
F
T
--------------------
G
V
V
D
L
V
K
M
K
A
I
-
N
W
N
D
A
D
Q
G
V
T
F
E
Y
----------------
E
D
I
P
A
D
M
V
E
L
A
N
E
W
H
Q
N
L
I
E
S
A
A
E
A
S
E
E
L
M
E
K
Y
L
G
G
E
E
L
T
E
A
E
I
K
G
A
L
R
---
Q
R
V
L
N
N
E
I
I
L
V
T
C
G
S
A
F
K
N
--
K
G
V
Q
A
M
L
D
A
V
I
D
Y
L
P
S
P
V
D
V
-
P
A
I
N
G
I
L
------
D
D
G
K
D
T
P
A
E
R
H
A
S
D
D
E
P
F
S
A
L
A
F
K
I
A
T
D
P
F
V
G
-
N
L
T
F
F
R
V
Y
S
G
V
V
N
S
G
D
T
V
L
N
S
V
K
A
---------
A
R
E
R
F
G
R
I
V
Q
M
H
A
N
K
R
E
E
I
K
E
V
R
A
G
D
I
A
A
A
I
G
L
K
D
V
-
T
T
G
D
T
L
C
D
-
P
-
D
A
-
P
I
--
I
L
E
R
M
E
-----
F
-
P
E
P
V
I
S
I
A
V
E
P
K
T
K
A
D
Q
E
K
M
G
L
A
L
G
R
L
A
K
E
D
P
S
F
R
V
W
T
D
E
E
S
N
Q
T
I
I
A
G
M
G
E
L
H
L
D
I
I
V
D
R
M
K
R
E
F
-
N
V
E
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
R
Q
K
V
T
D
V
E
G
K
H
A
K
Q
S
G
G
R
G
Q
Y
G
H
V
V
I
D
M
Y
P
L
E
P
G
S
NPK
G
Y
E
F
I
-----------------------------------------
N
D
I
K
G
G
V
I
P
----
G
E
Y
I
P
A
V
D
K
G
I
Q
E
Q
L
K
A
G
P
L
A
G
Y
P
V
V
D
M
G
I
R
L
H
F
G
S
Y
H
--
D
V
D
S
S
E
L
A
F
K
L
A
A
S
I
A
F
K
E
G
F
K
K
A
K
P
V
L
L
E
P
I
M
K
V
E
V
E
T
P
E
E
N
T
G
D
V
I
G
D
L
S
R
R
R
G
M
L
K
G
Q
E
S
E
V
T
--
G
V
K
I
H
A
E
V
P
L
S
E
M
F
G
Y
A
T
Q
L
R
S
L
T
K
G
R
A
S
Y
T
M
E
F
L
K
Y
D
E
A
P
------
S
N
V
A
Q
A
V
I
E
----------------------
4
PsiBlast_PDB
81.84
66%
-78
- C4 -
2EFG
1
EFG_THET8
A:
[7-689]
------------
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
--------------------
G
I
I
D
V
L
R
M
K
A
Y
-
T
Y
G
N
-
D
L
G
T
D
I
R
E
----------------
I
P
I
P
E
E
Y
L
D
N
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
---
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
--
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
-
P
P
I
K
G
T
T
------
P
E
-
G
E
-
V
V
E
I
H
P
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
-
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
---------
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
G
L
K
E
T
-
I
T
G
D
T
L
V
G
-
E
D
A
P
-
R
V
--
I
L
E
S
---------------------------------------------------------------------------------
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
-
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---
G
F
E
F
V
-----------------------------------------
N
A
I
V
G
G
V
I
P
----
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
--
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
--
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
------
K
Q
V
Q
E
K
L
I
K
----------------------
17
PsiBlast_PDB
75.30
35%
-69
- C4 -
1WDT
2
?
A:
[10-664]
------------------
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
R
G
R
V
E
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
R
G
-------
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
V
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
P
R
M
V
V
V
T
K
L
D
K
-
G
G
D
Y
Y
A
L
L
E
D
L
R
S
T
L
-
G
P
I
L
P
I
D
L
P
L
Y
E
G
G
K
W
V
--------------------
G
L
I
D
V
F
H
G
K
A
Y
-
R
Y
E
N
---
G
E
E
R
E
A
-----------------
E
V
P
P
E
E
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
E
V
T
G
E
A
L
E
K
A
F
H
---
E
A
V
R
R
G
L
L
Y
P
V
A
L
A
S
G
E
R
E
--
I
G
V
L
P
L
L
E
L
I
L
E
A
L
P
S
P
T
E
-------------------------
R
F
G
D
G
P
P
L
A
K
V
-
F
K
V
Q
V
D
P
F
M
G
-
Q
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
Q
--
S
E
A
---------
G
Q
V
R
L
P
H
L
Y
V
P
M
G
K
D
L
L
E
V
E
E
A
E
A
G
F
V
L
G
V
P
K
A
E
G
L
-
H
R
G
M
V
L
W
Q
G
E
-
K
P
-------
E
S
E
E
V
P
F
A
R
L
-
P
D
P
N
V
P
V
A
L
H
P
K
G
R
T
D
E
A
R
L
G
E
A
L
R
K
L
L
E
E
D
P
S
L
K
L
E
R
Q
E
E
T
G
E
L
L
L
W
G
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
-
D
Y
-
G
V
E
V
E
F
S
V
P
K
V
P
Y
R
E
T
I
K
K
V
A
E
-
G
Q
G
K
Y
K
K
Q
T
G
G
H
G
Q
Y
G
D
V
W
L
R
L
E
P
A
S
E
------
Y
G
F
E
-----------------------------------------
W
R
I
T
G
G
V
I
P
----
S
K
Y
Q
E
A
I
E
E
G
I
K
E
A
A
K
K
G
V
L
A
G
F
P
V
M
G
F
K
A
I
V
Y
N
G
S
Y
H
--
E
V
D
S
S
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
E
A
H
P
V
L
L
E
P
I
Y
R
L
K
V
L
A
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
R
I
L
G
M
E
Q
E
G
A
--
L
S
V
V
H
A
E
V
P
L
A
E
V
L
E
Y
Y
K
A
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
Y
A
E
V
P
------
P
H
L
A
Q
R
I
V
Q
E
R
A
Q
E
-----------------
109
HHSearch
75.28
35%
-71
* C4 *
2DY1
2
?
A:
[6-664]
--------------
G
A
M
I
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
R
G
R
V
E
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
R
G
-------
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
V
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
P
R
M
V
V
V
T
K
L
D
K
G
G
-
D
Y
Y
A
L
L
E
D
L
R
S
T
L
G
P
-
I
L
P
I
D
L
P
L
Y
E
G
G
K
W
V
--------------------
G
L
I
D
V
F
H
G
K
A
Y
R
Y
E
N
G
-
E
E
----
R
E
----------------
A
E
V
P
P
E
E
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
E
V
T
G
E
A
L
E
K
A
F
H
---
E
A
V
R
R
G
L
L
Y
P
V
A
L
A
S
G
E
R
E
--
I
G
V
L
P
L
L
E
L
I
L
E
A
L
P
S
P
T
E
R
--------------------------
F
G
D
G
P
P
L
A
K
V
F
K
V
Q
V
D
P
F
M
G
-
Q
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
Q
S
E
A
-----------
G
Q
V
R
L
P
H
L
Y
V
P
M
G
K
D
L
L
E
V
E
E
A
E
A
G
F
V
L
G
V
P
K
A
E
G
L
-
H
R
G
M
V
L
W
Q
-
G
-
E
K
-
P
E
SE
E
V
P
F
A
R
-----
L
-
P
D
P
N
V
P
V
A
L
H
P
K
G
R
T
D
E
A
R
L
G
E
A
L
R
K
L
L
E
E
D
P
S
L
K
L
E
R
Q
E
E
T
G
E
L
L
L
W
G
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
-
D
Y
-
G
V
E
V
E
F
S
V
P
K
V
P
Y
R
E
T
I
K
K
V
A
E
-
G
Q
G
K
Y
K
K
Q
T
G
G
H
G
Q
Y
G
D
V
W
L
R
L
E
P
A
S
------
E
Y
G
F
E
-----------------------------------------
W
R
I
T
G
G
V
I
P
----
S
K
Y
Q
E
A
I
E
E
G
I
K
E
A
A
K
K
G
V
L
A
G
F
P
V
M
G
F
K
A
I
V
Y
N
G
S
Y
H
--
E
V
D
S
S
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
E
A
H
P
V
L
L
E
P
I
Y
R
L
K
V
L
A
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
R
I
L
G
M
E
Q
E
G
A
--
L
S
V
V
H
A
E
V
P
L
A
E
V
L
E
Y
Y
K
A
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
Y
A
E
V
P
------
P
H
L
A
Q
R
I
V
Q
E
R
A
Q
E
-----------------
18
PsiBlast_PDB
75.26
35%
-71
- C4 -
2DY1
2
?
A:
[10-664]
------------------
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
R
G
R
V
E
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
R
G
-------
H
R
V
F
L
L
D
A
P
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134
Fugue
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