@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu01480: (2016-06-03 )
MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRIPVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHARFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAAKTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVKSMLEAKDREAAGRTAPGHGLYLWNVYYDN
Atome Classification :
(20 SA)
----------.........10........20-.-.--......30-....-------.----..-------.40........-----50----------........60.--......------------.70---.---....--....80.-.----------......----90-------------------...-.....-.100..----.....110.----...------...-120........------130.....--..140......-.---150-.......160--.-....-.--...170.--.....----.180-----..---...--..190.......200.......210.......220..-.....230.......240..-...--------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------
M
R
L
K
C
T
I
SYDG
H
L
FN
G
Y
Q
VQP-G-K--
R
T
V
Q
D
E
L
E
-
K
A
L
A
-------
V
----
L
H-------KSKDRI
P
V
VSS-----GR----------TDSGVHAAG
Q
V
--
I
H
FDTP------------LS----I---P
A
E
R--W
P
Y
A
L
N
A-L----------LPDDI
A
----
V
--------------------
K
Q
A
-EIADD-
G
F
H
A
R
F
----
S
A
V
K
K
E
Y
R
Y
----
F
V
Y
------TEK-H
P
-
D
V
F
K
R
H
Y
A
------
Y
H
F
S
Y
R
L
N
--
V
Q
D
M
R
E
A
A
K
H
L
-I---GTH-
D
F
T
S
F
C
AA----
K
-
T
E
V
Q
-
D
--
K
V
R
T
I
Y
E--LDWTE----TAD
G
-----
L
Q
---
M
R
I
--TG
S
G
F
L
Y
N
M
V
R
I
I
A
G
T
L
L
D
A
GIGKI
S
P
D
E
V
K
S
M
L
E
A
K
-
D
R
EAAGRTAPGH
G
L
Y
L
W
N
V
Y
-YDN--------------------------------------------
21
PsiBlast_CBE
88.78
37%
-108
- C3 -
1DJ0
1
TRUA_ECOLI
B:
[5-248]
-----------
K
I
A
L
G
I
E
Y
D
G
S
K
Y
Y
G
W
Q
R
Q
N
-
E
-
V
--
R
S
V
Q
E
K
L
E
-
K
A
L
S
-------
Q
----
V
---------
A
N
E
P
I
T
V
F
C
A
-----
G
R
----------
T
D
A
G
V
H
G
T
G
Q
V
--
V
H
F
E
T
T
------------
A
L
----
R
---
K
D
A
A
--
W
T
L
G
V
N
A
-
N
----------
L
P
G
D
I
A
----
V
--------------------
R
W
V
-
K
T
V
P
D
-
D
F
H
A
R
F
----
S
A
T
A
R
R
Y
R
Y
----
I
I
Y
------
N
H
R
L
R
P
-
A
V
L
S
K
G
V
T
-------
H
F
Y
E
P
L
D
--
A
E
R
M
H
R
A
A
Q
C
L
-
L
---
G
E
N
-
D
F
T
S
F
R
A
V
----
Q
-
C
Q
S
R
-
T
--
P
W
R
N
V
M
H
--
I
N
V
T
R
----
H
G
P
Y
-----
V
V
---
V
D
I
--
K
A
N
A
F
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
A
H
N
Q
P
E
S
W
I
A
E
L
L
A
A
K
-
D
R
T
L
A
A
A
T
A
K
A
E
G
L
Y
L
V
A
V
D
-
Y
P
D
--------------------------------------------
3
PsiBlast_PDB
88.66
37%
-105
- C3 -
2NQP
-
TRUA_ECOLI
A:
[11-254]
-----------
K
I
A
L
G
I
E
Y
D
G
S
K
Y
Y
G
W
Q
R
Q
N
-
E
-
V
--
R
S
V
Q
E
K
L
E
-
K
A
L
S
-------
Q
----
V
---------
A
N
E
P
I
T
V
F
C
A
-----
G
R
----------
T
D
A
G
V
H
G
T
G
Q
V
--
V
H
F
E
T
T
------------
A
L
----
R
---
K
D
A
A
--
W
T
L
G
V
N
A
-
N
----------
L
P
G
D
I
A
----
V
--------------------
R
W
V
-
K
T
V
P
D
-
D
F
H
A
R
F
----
S
A
T
A
R
R
Y
R
Y
----
I
I
Y
------
N
H
R
L
R
P
-
A
V
L
S
K
G
V
T
-------
H
F
Y
E
P
L
D
--
A
E
R
M
H
R
A
A
Q
C
L
-
L
---
G
E
N
-
D
F
T
S
F
R
A
V
----
Q
-
C
Q
S
R
-
T
--
P
W
R
N
V
M
H
--
I
N
V
T
R
----
H
G
P
Y
-----
V
V
---
V
D
I
--
K
A
N
A
F
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
A
H
N
Q
P
E
S
W
I
A
E
L
L
A
A
K
-
D
R
T
L
A
A
A
T
A
K
A
E
G
L
Y
L
V
A
V
D
-
Y
P
D
--------------------------------------------
1
PsiBlast_PDB
88.05
42%
-88
- C3 -
1VS3
-
TRUA_THET8
A:
[3-248]
-----------
R
L
L
L
L
C
E
Y
D
G
T
L
F
A
G
L
Q
R
Q
G
R
G
-
L
--
R
T
V
Q
G
E
L
E
-
R
A
L
P
-------
G
----
I
G
-------
A
L
P
K
---
A
V
A
A
-----
G
R
----------
T
D
A
G
V
H
A
L
A
M
P
--
F
H
V
D
V
E
------------
S
A
----
I
---
P
V
E
K
--
V
P
E
A
L
N
R
-
L
----------
L
P
E
D
L
K
----
V
--------------------
V
G
A
R
E
V
A
P
D
--
F
H
A
R
K
----
D
A
L
W
R
A
Y
R
Y
----
R
I
L
------
V
R
P
-
H
P
-
S
P
L
L
R
H
R
A
------
L
W
V
R
R
P
L
D
--
L
E
A
M
E
E
A
L
S
L
L
-
L
---
G
R
H
-
N
F
L
G
F
--
A
----
K
-
E
E
T
R
-
P
--
G
E
R
E
L
L
E
A
R
L
Q
V
A
E
----
G
E
A
G
-----
L
E
---
V
R
L
Y
F
R
G
K
S
F
L
R
G
Q
V
R
G
M
V
G
T
L
L
E
V
G
L
G
K
R
P
P
E
S
L
K
A
I
L
K
T
A
-
D
R
R
L
A
G
P
T
A
P
A
H
G
L
Y
F
V
E
A
A
-
Y
P
E
--------------------------------------------
2
PsiBlast_PDB
87.99
37%
-109
- C3 -
1DJ0
1
TRUA_ECOLI
A:
[5-248]
-----------
K
I
A
L
G
I
E
Y
D
G
S
K
Y
Y
G
W
Q
R
Q
N
-
E
-
V
--
R
S
V
Q
E
K
L
E
-
K
A
L
S
-------
Q
----
V
---------
A
N
E
P
I
T
V
F
C
A
-----
G
R
----------
T
D
A
G
V
H
G
T
G
Q
V
--
V
H
F
E
T
T
------------
A
L
----
R
---
K
D
A
A
--
W
T
L
G
V
N
A
-
N
----------
L
P
G
D
I
A
----
V
--------------------
R
W
V
-
K
T
V
P
D
-
D
F
H
A
R
F
----
S
A
T
A
R
R
Y
R
Y
----
I
I
Y
------
N
H
R
L
R
P
-
A
V
L
S
K
G
V
T
-------
H
F
Y
E
P
L
D
--
A
E
R
M
H
R
A
A
Q
C
L
-
L
---
G
E
N
-
D
F
T
S
F
R
A
V
----
Q
-
C
Q
S
R
-
T
--
P
W
R
N
V
M
H
--
I
N
V
T
R
----
H
G
P
Y
-----
V
V
---
V
D
I
--
K
A
N
A
F
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
A
H
N
Q
P
E
S
W
I
A
E
L
L
A
A
K
-
D
R
T
L
A
A
A
T
A
K
A
E
G
L
Y
L
V
A
V
D
-
Y
P
D
--------------------------------------------
22
PsiBlast_CBE
87.84
37%
-105
- C3 -
2NQP
1
TRUA_ECOLI
C:
[11-254]
-----------
K
I
A
L
G
I
E
Y
D
G
S
K
Y
Y
G
W
Q
R
Q
N
-
E
-
V
--
R
S
V
Q
E
K
L
E
-
K
A
L
S
-------
Q
----
V
---------
A
N
E
P
I
T
V
F
C
A
-----
G
R
----------
T
D
A
G
V
H
G
T
G
Q
V
--
V
H
F
E
T
T
------------
A
L
----
R
---
K
D
A
A
--
W
T
L
G
V
N
A
-
N
----------
L
P
G
D
I
A
----
V
--------------------
R
W
V
-
K
T
V
P
D
-
D
F
H
A
R
F
----
S
A
T
A
R
R
Y
R
Y
----
I
I
Y
------
N
H
R
L
R
P
-
A
V
L
S
K
G
V
T
-------
H
F
Y
E
P
L
D
--
A
E
R
M
H
R
A
A
Q
C
L
-
L
---
G
E
N
-
D
F
T
S
F
R
A
V
----
Q
-
C
Q
S
R
-
T
--
P
W
R
N
V
M
H
--
I
N
V
T
R
----
H
G
P
Y
-----
V
V
---
V
D
I
--
K
A
N
A
F
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
A
H
N
Q
P
E
S
W
I
A
E
L
L
A
A
K
-
D
R
T
L
A
A
A
T
A
K
A
E
G
L
Y
L
V
A
V
D
-
Y
P
D
--------------------------------------------
32
HHSearch
87.52
37%
-112
- C3 -
1DJ0
1
TRUA_ECOLI
A:
[4-248]
----------
Y
K
I
A
L
G
I
E
Y
D
G
S
K
Y
Y
G
W
Q
R
Q
N
-
E
-
V
--
R
S
V
Q
E
K
L
E
-
K
A
L
S
-------
Q
----
V
A
---------
N
E
P
I
T
V
F
C
A
-----
G
R
----------
T
D
A
G
V
H
G
T
G
Q
V
--
V
H
F
E
T
T
------------
A
L
----
R
---
K
D
A
A
--
W
T
L
G
V
N
A
-
N
----------
L
P
G
D
I
A
----
V
--------------------
R
W
V
-
K
T
V
P
D
-
D
F
H
A
R
F
----
S
A
T
A
R
R
Y
R
Y
----
I
I
Y
------
N
H
R
-
L
R
-
P
A
V
L
S
K
G
V
------
T
H
F
Y
E
P
L
D
--
A
E
R
M
H
R
A
A
Q
C
L
-
L
---
G
E
N
-
D
F
T
S
F
R
A
V
----
Q
-
C
Q
S
R
-
T
--
P
W
R
N
V
M
H
--
I
N
V
T
R
----
H
G
P
Y
-----
V
V
---
V
D
I
--
K
A
N
A
F
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
A
H
N
Q
P
E
S
W
I
A
E
L
L
A
A
K
-
D
R
T
L
A
A
A
T
A
K
A
E
G
L
Y
L
V
A
V
D
-
Y
P
D
--------------------------------------------
42
Fugue
87.10
36%
-111
* C3 *
1DJ0
1
TRUA_ECOLI
A:
[1-264]
-------P
P
V
Y
K
I
A
L
G
I
E
Y
D
G
S
K
Y
Y
G
W
Q
R
Q
N
-
E
-
V
--
R
S
V
Q
E
K
L
E
-
K
A
L
S
-------
Q
----
V
A
-------
N
E
P
--
I
T
V
F
C
A
-----
G
R
----------
T
D
A
G
V
H
G
T
G
Q
V
--
V
H
F
E
T
T
------------
A
L
----
R
---
K
D
A
A
--
W
T
L
G
V
N
A
-
N
----------
L
P
G
D
I
A
----
V
--------------------
R
W
V
-
K
T
V
P
D
-
D
F
H
A
R
F
----
S
A
T
A
R
R
Y
R
Y
----
I
I
Y
------
N
H
R
-
L
R
-
P
A
V
L
S
K
G
V
------
T
H
F
Y
E
P
L
D
--
A
E
R
M
H
R
A
A
Q
C
L
-
L
---
G
E
N
-
D
F
T
S
F
R
A
V
----
Q
-
C
Q
S
R
-
T
--
P
W
R
N
V
M
H
--
I
N
V
T
R
----
H
G
P
Y
-----
V
V
---
V
D
I
--
K
A
N
A
F
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
A
H
N
Q
P
E
S
W
I
A
E
L
L
A
A
K
-
D
R
T
L
A
A
A
T
A
K
A
E
G
L
Y
L
V
A
V
D
-
Y
P
D
RYD
L
P
K
P
PMGPLFLAD----------------------------
4
PsiBlast_PDB
87.06
37%
-108
- C3 -
2NR0
-
TRUA_ECOLI
A:
[11-254]
-----------
K
I
A
L
G
I
E
Y
D
G
S
K
Y
Y
G
W
Q
R
Q
N
-
E
-
V
--
R
S
V
Q
E
K
L
E
-
K
A
L
S
-------
Q
----
V
---------
A
N
E
P
I
T
V
F
C
A
-----
G
R
----------
T
D
A
G
V
H
G
T
G
Q
V
--
V
H
F
E
T
T
------------
A
L
----
R
---
K
D
A
A
--
W
T
L
G
V
N
A
-
N
----------
L
P
G
D
I
A
----
V
--------------------
R
W
V
-
K
T
V
P
D
-
D
F
H
A
R
F
----
S
A
T
A
R
R
Y
R
Y
----
I
I
Y
------
N
H
R
L
R
P
-
A
V
L
S
K
G
V
T
-------
H
F
Y
E
P
L
D
--
A
E
R
M
H
R
A
A
Q
C
L
-
L
---
G
E
N
-
D
F
T
S
F
R
A
V
----
Q
-
C
Q
S
R
-
T
--
P
W
R
N
V
M
H
--
I
N
V
T
R
----
H
G
P
Y
-----
V
V
---
V
D
I
--
K
A
N
A
F
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
A
H
N
Q
P
E
S
W
I
A
E
L
L
A
A
K
-
D
R
T
L
A
A
A
T
A
K
A
E
G
L
Y
L
V
A
V
D
-
Y
P
D
--------------------------------------------
33
HHSearch
86.17
39%
-95
- C3 -
1VS3
-
TRUA_THET8
A:
[2-248]
----------
R
R
L
L
L
L
C
E
Y
D
G
T
L
F
A
G
L
Q
R
Q
G
-
R
G
L
--
R
T
V
Q
G
E
L
E
-
R
A
L
P
-------
G
----
I
G
-------
A
---
L
P
K
A
V
A
A
-----
G
R
----------
T
D
A
G
V
H
A
L
A
M
P
--
F
H
V
D
V
E
------------
S
A
----
I
---
P
V
E
K
--
V
P
E
A
L
N
R
-
L
----------
L
P
E
D
L
K
----
V
--------------------
V
G
A
-
R
E
V
A
P
-
D
F
H
A
R
K
----
D
A
L
W
R
A
Y
R
Y
----
R
I
L
------
V
R
P
-
H
P
-
S
P
L
L
R
H
R
A
------
L
W
V
R
R
P
L
D
--
L
E
A
M
E
E
A
L
S
L
L
-
L
---
G
R
H
-
N
F
L
G
F
A
K
E
----
E
-
T
--
R
-
P
--
G
E
R
E
L
L
E
--
A
R
L
Q
V
A
EGE
A
G
L
E
-----
V
R
---
L
Y
F
--
R
G
K
S
F
L
R
G
Q
V
R
G
M
V
G
T
L
L
E
V
G
L
G
K
R
P
P
E
S
L
K
A
I
L
K
T
A
-
D
R
R
L
A
G
P
T
A
P
A
H
G
L
Y
F
V
E
A
A
-
Y
P
E
--------------------------------------------
5
PsiBlast_PDB
85.78
37%
-98
- C3 -
2NRE
-
TRUA_ECOLI
A:
[11-254]
-----------
K
I
A
L
G
I
E
Y
D
G
S
K
Y
Y
G
W
Q
R
Q
N
-
E
-
V
--
R
S
V
Q
E
K
L
E
-
K
A
L
S
-------
Q
----
V
---------
A
N
E
P
I
T
V
F
C
A
-----
G
R
----------
T
D
A
G
V
H
G
T
G
Q
V
--
V
H
F
E
T
T
------------
A
L
----
R
---
K
D
A
A
--
W
T
L
G
V
N
A
-
N
----------
L
P
G
D
I
A
----
V
--------------------
R
W
V
-
K
T
V
P
D
-
D
F
H
A
R
F
----
S
A
T
A
R
R
Y
R
Y
----
I
I
Y
------
N
H
R
L
R
P
-
A
V
L
S
K
G
V
T
-------
H
F
Y
E
P
L
D
--
A
E
R
M
H
R
A
A
Q
C
L
-
L
---
G
E
N
-
D
F
T
S
F
R
A
V
-----------
T
--
P
W
R
N
V
M
H
--
I
N
V
T
R
----
H
G
P
Y
-----
V
V
---
V
D
I
--
K
A
N
A
F
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
A
H
N
Q
P
E
S
W
I
A
E
L
L
A
A
K
-
D
R
T
L
A
A
A
T
A
K
A
E
G
L
Y
L
V
A
V
D
-
Y
P
D
--------------------------------------------
7
PsiBlast_PDB
74.08
24%
-79
- C3 -
4IQM
-
TRUA_HUMAN
A:
[90-350]
----------------
M
A
Y
S
G
K
G
Y
H
G
M
Q
R
N
-----F-
K
T
I
E
D
D
L
V
-
S
A
L
V
-------
R
----
S
G
CIP
E
N
H
G
E
D
M
R
K
M
S
F
Q
R
C
-----
A
R
----------
T
D
K
G
V
S
A
A
G
Q
V
--
V
S
L
K
V
W
------------
L
----------
I
D
D
--
I
L
E
K
I
N
S
-
H
----------
L
P
S
H
I
R
----
I
--------------------
L
G
L
-
K
R
V
T
G
-
G
F
N
S
K
N
----
R
C
D
A
R
T
Y
C
Y
L
L
P
T
F
A
F
------
A
H
K
-
D
R
-
D
V
Q
D
E
------------
T
Y
R
L
S
--
A
E
T
L
Q
Q
V
N
R
L
L
-
A
C
Y
K
G
T
H
-
N
F
H
N
F
T
S
Q
----
K
G
P
Q
D
P
-
S
--
A
C
R
Y
I
L
E
--
M
Y
C
E
E
P
F
--
V
R
E
G
-----
L
E
F
A
V
I
R
V
--
K
G
Q
S
F
M
M
H
Q
I
R
K
M
V
G
-
L
V
V
A
I
V
K
G
Y
A
P
E
S
V
L
E
R
S
W
G
T
-
E
K
V
D
V
P
K
-
A
P
G
L
G
L
V
L
E
R
V
H
-
F
E
---------------------------------------------
8
PsiBlast_PDB
73.75
25%
-83
- C3 -
4NZ7
2
TRUA_HUMAN
A:
[9-263]
----------------
M
A
Y
S
G
K
G
Y
H
G
M
Q
-------QF
K
T
I
E
D
D
L
V
-
S
A
L
V
-------
R
----
S
G
CIP
E
N
H
G
E
D
M
R
K
M
S
F
Q
R
C
-----
A
R
----------
T
A
K
G
V
S
A
A
G
Q
V
--
V
S
L
K
V
W
------------
L
----------
I
D
D
--
I
L
E
K
I
N
S
-
H
----------
L
P
S
H
I
R
----
I
--------------------
L
G
L
-
K
R
V
T
G
-
G
F
N
S
K
N
----
R
C
D
A
R
T
Y
C
Y
L
L
P
T
F
A
F
------
A
H
K
-
D
R
-
D
V
Q
D
E
------------
T
Y
R
L
S
--
A
E
T
L
Q
Q
V
N
R
L
L
-
A
C
Y
K
G
T
H
-
N
F
H
N
F
T
S
Q
----
K
-
G
P
-
Q
-
D
PS
A
C
R
Y
I
L
E
--
M
Y
C
E
E
P
F
--
V
R
E
G
-----
L
E
F
A
V
I
R
V
--
K
G
Q
S
F
M
M
H
Q
I
R
K
M
V
G
-
L
V
V
A
I
V
K
G
Y
A
P
E
S
V
L
E
R
S
W
G
T
-
E
K
V
D
V
P
K
-
A
P
G
L
G
L
V
L
E
R
V
H
-
F
E
---------------------------------------------
6
PsiBlast_PDB
73.27
25%
-77
- C3 -
4NZ6
3
TRUA_HUMAN
A:
[9-262]
----------------
M
A
Y
S
G
K
G
Y
H
G
M
Q
R
------QF
K
T
I
E
D
D
L
V
-
S
A
L
V
-------
R
----
S
G
CIP
E
N
H
G
E
D
M
R
K
M
S
F
Q
R
C
-----
A
R
----------
T
D
K
G
V
S
A
A
G
Q
V
--
V
S
L
K
V
W
------------
L
----------
I
D
D
--
I
L
E
K
I
N
S
-
H
----------
L
P
S
H
I
R
----
I
--------------------
L
G
L
-
K
R
V
T
G
-
G
F
N
S
K
N
----
R
C
D
A
R
T
Y
C
Y
L
L
P
T
F
A
F
------
A
H
K
-
D
R
-
D
V
Q
D
E
------------
T
Y
R
L
S
--
A
E
T
L
Q
Q
V
N
R
L
L
-
A
C
Y
K
G
T
H
-
N
F
H
N
F
T
S
Q
----
K
-
G
P
-
Q
-
D
PS
A
C
R
Y
I
L
E
--
M
Y
C
E
E
P
F
--
V
R
E
G
-----
L
E
F
A
V
I
R
V
--
K
G
Q
S
F
M
M
H
Q
I
R
K
M
V
G
-
L
V
V
A
I
V
K
G
Y
A
P
E
S
V
L
E
R
S
W
G
T
-
E
K
V
D
V
P
K
-
A
P
G
L
G
L
V
L
E
R
V
H
-
F
E
---------------------------------------------
43
Fugue
70.42
23%
-84
- C3 -
4J37
4
TRUA_HUMAN
A:
[9-327]
-------P
P
K
R
K
I
V
L
L
M
A
Y
S
G
K
G
Y
H
G
M
Q
R
N
Q
---
F
--
K
T
I
E
D
D
L
V
-
S
A
L
V
R
S
GCIP
E
N
----
H
G
-------
E
D
M
R
K
M
S
F
Q
R
C
-----
A
R
----------
T
D
K
G
V
S
A
A
G
Q
V
--
V
S
L
K
V
W
----------------------
L
I
D
D
--
I
L
E
K
I
N
S
-
H
----------
L
P
S
H
I
R
----
I
--------------------
L
G
L
-
K
R
V
T
G
-
G
F
N
R
C
-----
D
A
R
T
Y
C
Y
L
L
----
P
T
F
------
A
F
A
-
H
K
-
D
R
D
V
Q
D
E
T
------
Y
R
L
S
-
A
E
T
--
L
Q
Q
V
N
R
L
L
A
C
Y
-
K
---
G
T
H
-
N
F
H
N
F
T
S
Q
----
K
-
G
P
Q
D
P
S
--
A
C
R
Y
I
L
E
--
M
Y
C
E
E
----
P
F
V
R
EG
L
E
F
A
V
---
I
R
V
--
K
G
Q
S
F
M
M
H
Q
I
R
K
M
V
G
L
V
V
A
I
V
K
G
Y
A
P
E
S
V
L
E
R
S
W
G
T
E
-
K
V
D
V
P
--
K
A
P
G
L
G
L
V
L
E
R
V
H
-
F
E
P
LDWAQE
E
G
K
V
A
A
F
K
E
E
H
I
Y
P
T
I
I
G
T
E
R
D
ER
S
M
A
Q
W
L
S
T
LPIHNF
47
Fugue
54.53
21%
-61
- C3 -
4RHJ
1
?
A:
[19-318]
---------------
S
H
M
F
S
K
F
L
M
N
V
K
G
V
T
P
-
R
-
G
--
S
D
W
A
N
R
L
G
P
V
A
L
F
-------
G
Y
G
A
G
M
P
-------
R
R
A
P
L
L
D
F
F
L
Q
-----
S
P
----------
R
D
C
D
-
H
Y
A
E
L
T
--
I
H
D
K
G
P
------------
I
E
----
C
---
P
P
E
T
V
M
F
M
P
V
L
N
C
G
Q
----------
M
L
D
E
A
A
GTET
P
--------------------
T
S
D
-
E
W
Y
L
G
-
S
L
E
A
S
T
----
E
L
L
E
K
G
Y
V
P
----
V
S
V
G
GDG
S
A
T
L
S
-
M
V
-
E
A
Y
K
R
L
F
P
S
D
D
I
V
I
V
H
F
S
A
R
P
S
--
V
S
D
P
R
S
P
L
R
V
L
-
L
---
D
K
G
-
L
L
K
G
V
V
S
V
GNRQ
V
-
S
S
E
D
-
R
--
K
V
R
K
L
H
K
--
M
F
Y
M
D
------------------
M
R
D
--
I
R
N
D
--
Y
P
V
F
I
S
I
D
A
S
V
L
D
P
A
F
A
P
A
V
D
S
P
V
A
G
G
L
S
T
R
-
D
L
L
H
I
M
N
G
I
R
G
P
K
V
V
G
I
D
V
Y
G
Y
N
P
DL
D
V
Y
R
KDNVG
L
T
A
I
A
L
S
K
I
I
K
E
G
I
LK-----------------
46
Fugue
47.53
18%
-53
- C3 -
4QTZ
-
?
A:
[6-326]
LG
N
V
V
C
V
T
GA
S
G
Y
I
A
S
W
L
V
R
L
L
L
H
R
G
Y
T
V
K
A
-
T
-
V
--
R
D
P
N
D
P
K
K
V
D
H
L
V
-------
K
----
L
D
-------
G
A
K
E
R
L
Q
L
F
K
A
N
LLEE
G
A
----------
F
D
S
V
V
Q
G
C
H
G
V
--
F
H
T
A
S
P
F
Y
H
DVKDPQAEL
I
D
----
P
---
A
L
K
G
--
T
L
N
V
L
N
S
-
C
A
K
SPSLK
R
V
V
L
T
S
S
I
A
----
A
VAYNGKPRTPDVVVDETWFT
D
A
D
-
F
C
A
K
S
-
N
L
W
Y
V
V
----
S
K
T
L
A
E
E
A
A
----
W
K
F
------
V
K
E
-
N
N
I
D
M
V
T
I
N
P
A
------
M
V
I
G
P
L
L
Q
PV
L
N
T
S
A
A
A
I
L
N
L
-
I
N--
G
A
Q
-
T
F
P
N
A
S
F
G
----
W
-
V
N
V
K
-
D
--
V
A
N
A
H
I
L
--
A
Y
E
N
A
----
S
A
S
G
-----
R
H
---
C
L
V
--
E
R
V
A
H
Y
S
E
V
V
R
I
L
R
E
L
Y
P
S
L
Q
L
P
E
K
C
A
D
D
K
P
Y
V
P
I
Y
Q
V
S
K
E
K
A
K
S
--
L
G
L
E
Y
T
P
L
E
V
S
-
I
K
E
T
V
E
S
L
K
E
K
KFANL-------------------------------
35
HHSearch
38.45
16%
-54
- C3 -
2V9K
4
PUS10_HUMAN
A:
[317-440]
-------------------------------------
S
S
V
E
E
L
I
S
-
D
H
L
L
-------
A
----
V
F
-------
K
-
A
E
S
F
N
F
S
S
S
-----
G
R
----------
E
D
V
D
V
R
T
L
G
N
G
R
P
F
A
I
E
L
V
------------
N
P
HRVH
F
T
S
Q
E
I
K
E
--
L
Q
Q
K
I
N
N
------------
S
S
N
K
I
Q
----
V
--------------------
R
D
L
-
Q
L
V
T
R
-
E
A
I
G
H
M
K
E
G
E
E
E
K
T
K
T
Y
S
A
----
L
I
W
------
T
N
K
-----------------------
A
I
Q
--
K
K
D
I
E
F
L
N
D
I
K
-
D
---
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
35.48
11%
-21
- C3 -
3I4H
-
CAS6_PYRFU
X:
[3-245]
------HHHG
S
R
F
L
I
R
L
V
P
E
D
K
D
R
A
F
K
V
P
Y
N
-
H
-
Q
--
Y
Y
L
Q
G
L
I
Y
-
N
A
I
K
-------
S
----
S
N
-------
P
K
L
A
T
Y
L
H
E
V
K
-----
G
P
KLFTYSLFMA
E
K
R
E
H
P
K
G
L
P
Y
--
F
L
G
Y
K
K
------------
G
F
----
F
---
Y
F
S
T
--
C
V
P
E
I
A
E
-
A
----------
L
V
N
G
L
L
M---
N
--------------------
P
E
V
-
R
L
W
D
E
-
R
F
Y
L
H
E
----
I
K
V
L
R
E
P
K
K
FNG-
S
T
F
------
V
T
L
-
S
P
-
I
A
V
T
V
V
Y
D
------
V
P
P
M
---
E
--
K
E
F
Y
S
I
I
K
D
D
L
-
Q
---
D
K
Y
-
V
M
A
Y
G
D
K
P
----
P
-
S
E
F
E
-
M
--
E
V
L
I
A
K
P
--
K
R
F
R
Q
----
T
A
W
H
-----
L
V
---
F
R
A
--
Y
G
N
-------
D
D
L
L
K
V
G
Y
E
V
G
F
G
E
--------------------
K
N
S
L
G
F
G
M
----
V
K
-
V
E
G
--------------------------------------------
9
PsiBlast_PDB
33.88
32%
4
- C3 -
2PRR
1
?
A:
[8-59]
--------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
R
--
Y
P
V
P
E
L
A
-
A
----------
L
P
D
D
I
R
----
Q
--------------------
R
I
L
-
E
V
Q
D
K
A
G
F
V
P
-------------
N
V
----
F
L
T
------
L
A
H
-
R
P
-
D
E
F
R
A
F
F
A
------
Y
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
33.58
44%
173
- C3 -
3PF6
-
?
A:
[24-41]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
E
E
A
R
L
L
F
P
G
---
G
T
H
H
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------