@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu01630: (2016-06-03 )
MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYLDKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGEKMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLTGKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYGDLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWKSLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN
Atome Classification :
(20 SA)
.........10........20........30........40.---.-...-.-.-.50....--....60-...--.-.....-70....--....80..-..--.--....90.-..--...---..100........110.......120...-..------..130..-..-...140.----.---.----.-...150.---......160.--......170...---....180......---.190--........200......-...210.......220...--..--..-----230------........------.240.......250.......260-.---........270..----.....280....-..-.290..---.--....300.......310.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
I
S
L
T
L
L
I
L
L
L
A
L
T
A
A
ACGSKNESTASKASGTA
S
E
K
K
K
I
E
---Y-LD
K
-
T
-
Y
-
E
V
T
VPT
D
--
K
I
A
I
T--GSV--E-SMED
A
-
K
L
L
D
VH--PQ
G
A
I
-
S
F-SG--K--F
P
D
M
F
K
D
-
I
T--DKA---EPTG-EKMEP
N
I
E
K
I
LEMKP
D
V
I
L
ASTKF-
P
E
------
K
T
L
Q
K
I
S-TA-G
T
T
I
P
V
S
----
H
---I----S-SN
W
K
E
N
M
---
M
L
L
A
Q
LTG
K
E
--
K
K
A
K
K
I
I
A
D
Y
E
Q
---
D
L
K
E
I
K
T
KINDKA---KDS---
K
A
L
V
I
R
I
RQ--G
N
I
Y
I
Y
-
P
E
Q
V
Y
FNS
T
L
YGDLGLKAP--
N
E
--
V
K
-----
A
--------
A
K
A
Q
E
L
S
S
------
L
E
K
L
SEMNP
D
H
I
F
V
Q
FSDDENA---D---K
P
D
A
L
K
D
LEKN
P
I
----
W
K
S
L
K
A
V
KED
H
V
-
Y
V-NSV
D
P
L---A--QGGT
A
W
S
K
V
R
F
L
K
A
A
A
E
K
LTQN
4
PsiBlast_PDB
99.49
98%
-80
- C1 -
2XV1
6
FEUA_BACSU
A:
[18-298]
------------------------------------
E
K
K
K
I
E
---
Y
-
L
D
K
-
T
-
Y
-
E
V
T
V
P
T
D
--
K
I
A
I
T
--
G
S
V
--
E
-
S
M
E
D
A
-
K
L
L
D
V
H
--
P
Q
G
A
I
-
S
F
-
S
G
--
K
--
F
P
D
M
F
K
D
-
I
T
--
D
K
A
---
E
P
T
G
-
E
K
M
E
P
N
I
E
K
I
L
E
M
K
P
D
V
I
L
A
S
T
K
F
-
P
E
------
K
T
L
Q
K
I
S
-
T
A
-
G
T
T
I
P
V
S
----
H
---
I
----
S
-
S
N
W
K
E
N
M
---
M
L
L
A
Q
L
T
G
K
E
--
K
K
A
K
K
I
I
A
D
Y
E
Q
---
D
L
K
E
T
K
T
K
I
N
D
K
A
---
K
D
S
---
K
A
L
V
I
R
I
R
Q
--
G
N
I
Y
I
Y
-
P
E
Q
V
Y
F
N
S
T
L
Y
G
D
L
G
L
K
A
P
--
N
E
--
V
K
-----
A
--------
A
K
A
Q
E
L
I
S
------
L
E
K
L
S
E
M
N
P
D
H
I
F
V
Q
F
S
D
D
E
N
A
---
D
---
K
P
D
A
L
K
D
L
E
K
N
P
I
----
W
K
S
L
K
A
V
K
E
D
H
V
-
Y
V
-
N
S
V
D
P
L
---
A
--
Q
G
G
T
A
W
S
K
V
R
F
L
K
A
A
A
E
K
L
T
Q
N
1
PsiBlast_PDB
99.24
98%
-79
- C1 -
2WI8
3
FEUA_BACSU
A:
[17-298]
-----------------------------------
S
E
K
K
K
I
E
---
Y
-
L
D
K
-
T
-
Y
-
E
V
T
V
P
T
D
--
K
I
A
I
T
--
G
S
V
--
E
-
S
M
E
D
A
-
K
L
L
D
V
H
--
P
Q
G
A
I
-
S
F
-
S
G
--
K
--
F
P
D
M
F
K
D
-
I
T
--
D
K
A
---
E
P
T
G
-
E
K
M
E
P
N
I
E
K
I
L
E
M
K
P
D
V
I
L
A
S
T
K
F
-
P
E
------
K
T
L
Q
K
I
S
-
T
A
-
G
T
T
I
P
V
S
----
H
---
I
----
S
-
S
N
W
K
E
N
M
---
M
L
L
A
Q
L
T
G
K
E
--
K
K
A
K
K
I
I
A
D
Y
E
Q
---
D
L
K
E
T
K
T
K
I
N
D
K
A
---
K
D
S
---
K
A
L
V
I
R
I
R
Q
--
G
N
I
Y
I
Y
-
P
E
Q
V
Y
F
N
S
T
L
Y
G
D
L
G
L
K
A
P
--
N
E
--
V
K
-----
A
--------
A
K
A
Q
E
L
I
S
------
L
E
K
L
S
E
M
N
P
D
H
I
F
V
Q
F
S
D
D
E
N
A
---
D
---
K
P
D
A
L
K
D
L
E
K
N
P
I
----
W
K
S
L
K
A
V
K
E
D
H
V
-
Y
V
-
N
S
V
D
P
L
---
A
--
Q
G
G
T
A
W
S
K
V
R
F
L
K
A
A
A
E
K
L
T
Q
N
2
PsiBlast_PDB
98.98
98%
-79
- C1 -
2WHY
11
FEUA_BACSU
A:
[19-298]
-------------------------------------
K
K
K
I
E
---
Y
-
L
D
K
-
T
-
Y
-
E
V
T
V
P
T
D
--
K
I
A
I
T
--
G
S
V
--
E
-
S
M
E
D
A
-
K
L
L
D
V
H
--
P
Q
G
A
I
-
S
F
-
S
G
--
K
--
F
P
D
M
F
K
D
-
I
T
--
D
K
A
---
E
P
T
G
-
E
K
M
E
P
N
I
E
K
I
L
E
M
K
P
D
V
I
L
A
S
T
K
F
-
P
E
------
K
T
L
Q
K
I
S
-
T
A
-
G
T
T
I
P
V
S
----
H
---
I
----
S
-
S
N
W
K
E
N
M
---
M
L
L
A
Q
L
T
G
K
E
--
K
K
A
K
K
I
I
A
D
Y
E
Q
---
D
L
K
E
T
K
T
K
I
N
D
K
A
---
K
D
S
---
K
A
L
V
I
R
I
R
Q
--
G
N
I
Y
I
Y
-
P
E
Q
V
Y
F
N
S
T
L
Y
G
D
L
G
L
K
A
P
--
N
E
--
V
K
-----
A
--------
A
K
A
Q
E
L
I
S
------
L
E
K
L
S
E
M
N
P
D
H
I
F
V
Q
F
S
D
D
E
N
A
---
D
---
K
P
D
A
L
K
D
L
E
K
N
P
I
----
W
K
S
L
K
A
V
K
E
D
H
V
-
Y
V
-
N
S
V
D
P
L
---
A
--
Q
G
G
T
A
W
S
K
V
R
F
L
K
A
A
A
E
K
L
T
Q
N
3
PsiBlast_PDB
98.36
98%
-77
- C1 -
2XUZ
6
FEUA_BACSU
A:
[19-298]
-------------------------------------
K
K
K
I
E
---
Y
-
L
D
K
-
T
-
Y
-
E
V
T
V
P
T
D
--
K
I
A
I
T
--
G
S
V
--
E
-
S
M
E
D
A
-
K
L
L
D
V
H
--
P
Q
G
A
I
-
S
F
-
S
G
--
K
--
F
P
D
M
F
K
D
-
I
T
--
D
K
A
---
E
P
T
G
-
E
K
M
E
P
N
I
E
K
I
L
E
M
K
P
D
V
I
L
A
S
T
K
F
-
P
E
------
K
T
L
Q
K
I
S
-
T
A
-
G
T
T
I
P
V
S
----
H
---
I
----
S
-
S
N
W
K
E
N
M
---
M
L
L
A
Q
L
T
G
K
E
--
K
K
A
K
K
I
I
A
D
Y
E
Q
---
D
L
K
E
T
K
T
K
I
N
D
K
A
---
K
D
S
---
K
A
L
V
I
R
I
R
Q
--
G
N
I
Y
I
Y
-
P
E
Q
V
Y
F
N
S
T
L
Y
G
D
L
G
L
K
A
P
--
N
E
--
V
K
-----
A
--------
A
K
A
Q
E
L
I
S
------
L
E
K
L
S
E
M
N
P
D
H
I
F
V
Q
F
S
D
D
E
N
A
---
D
---
K
P
D
A
L
K
D
L
E
K
N
P
I
----
W
K
S
L
K
A
V
K
E
D
H
V
-
Y
V
-
N
S
V
D
P
L
---
A
--
Q
G
G
T
A
W
S
K
V
R
F
L
K
A
A
A
E
K
L
T
Q
N
31
HHSearch
95.64
94%
-75
- C1 -
2WI8
3
FEUA_BACSU
A:
[17-298]
-----------------------------------
S
E
K
K
K
I
E
---
Y
-
L
D
K
-
T
-
Y
-
E
V
T
V
P
T
D
--
K
I
-
A
I
--
T
G
S
--
V
E
S
M
E
D
A
-
K
L
L
D
V
H
--
P
Q
G
A
I
-
S
F
-
S
G
--
K
--
F
P
D
M
F
K
D
-
I
T
--
D
K
A
---
E
P
T
G
-
E
K
M
E
P
N
I
E
K
I
L
E
M
K
P
D
V
I
L
A
S
T
K
F
-
P
E
------
K
T
L
Q
K
I
S
-
T
A
-
G
T
T
I
P
V
S
----
H
---
I
----
S
-
S
N
W
K
E
N
M
---
M
L
L
A
Q
L
T
G
K
E
--
K
K
A
K
K
I
I
A
D
Y
E
Q
---
D
L
K
E
T
K
T
K
I
N
D
K
A
---
K
D
S
---
K
A
L
V
I
R
I
R
Q
--
G
N
I
Y
I
Y
-
P
E
Q
V
Y
F
N
S
T
L
Y
G
D
L
G
L
K
A
P
--
N
E
--
V
K
-----
A
--------
A
K
A
Q
E
L
I
S
------
L
E
K
L
S
E
M
N
P
D
H
I
F
V
Q
F
S
D
D
E
N
A
---
D
---
K
P
D
A
L
K
D
L
E
K
N
P
I
----
W
K
S
L
K
A
V
K
E
D
H
V
-
Y
V
-
N
S
V
D
P
L
AQ-
G
--
G
T
A
W
S
K
V
R
F
--
L
K
A
A
A
E
K
L
T
Q
N
11
PsiBlast_PDB
62.35
24%
-39
- C1 -
3LHS
4
?
A:
[12-282]
------------------------------------------------
D
E
-
N
-
G
-
T
V
K
V
P
K
D
--
A
K
R
I
V
--
V
L
E
--
Y
-
S
F
A
D
A
L
A
A
L
D
V
K
--
P
V
G
-
I
-
A
D
-
D
G
--
K
--
K
K
R
I
I
K
P
-
V
R
--
E
K
I
G
D
Y
T
S
V
G
-
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
K
------
G
I
N
K
E
L
N
-
K
I
-
A
P
T
L
S
L
K
----
S
---
F
----
D
-
G
D
Y
K
Q
N
I
N
S
F
K
T
I
A
K
A
L
N
K
E
--
K
E
G
E
K
R
L
A
E
H
D
K
---
L
I
N
K
Y
K
D
E
I
K
F
D
----
R
N
Q
---
K
V
L
P
A
V
V
A
K
--
A
G
L
L
A
H
-
P
N
Y
S
Y
V
G
Q
F
L
-
N
E
L
G
F
K
N
A
LS
D
D
--
V
T
-----
K
--------
G
L
S
K
Y
L
K
G
P
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
R
M
I
I
-
M
T
D
H
A
K
K
---
D
---
S
A
E
-
F
K
K
L
Q
E
D
A
T
----
W
K
K
L
N
A
V
K
N
N
R
V
-
D
I
-
V
D
R
D
------------
V
W
A
R
S
R
G
L
I
S
S
E
E
-----
10
PsiBlast_PDB
62.17
24%
-38
- C1 -
3EIW
1
?
A:
[12-282]
------------------------------------------------
D
E
-
N
-
G
-
T
V
K
V
P
K
D
--
A
K
R
I
V
--
V
L
E
--
Y
-
S
F
A
D
A
L
A
A
L
D
V
K
--
P
V
G
-
I
-
A
D
-
D
G
--
K
--
K
K
R
I
I
K
P
-
V
R
--
E
K
I
G
D
Y
T
S
V
G
-
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
K
------
G
I
N
K
E
L
N
-
K
I
-
A
P
T
L
S
L
K
----
S
---
F
----
D
-
G
D
Y
K
Q
N
I
N
S
F
K
T
I
A
K
A
L
N
K
E
--
K
E
G
E
K
R
L
A
E
H
D
K
---
L
I
N
K
Y
K
D
E
I
K
F
D
----
R
N
Q
---
K
V
L
P
A
V
V
A
K
--
A
G
L
L
A
H
-
P
N
Y
S
Y
V
G
Q
F
L
-
N
E
L
G
F
K
N
A
LS
D
D
--
V
T
-----
K
--------
G
L
S
K
Y
L
K
G
P
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
R
M
I
I
-
M
T
D
H
A
K
K
---
D
---
S
A
E
-
F
K
K
L
Q
E
D
A
T
----
W
K
K
L
N
A
V
K
N
N
R
V
-
D
I
-
V
D
R
D
------------
V
W
A
R
S
R
G
L
I
S
S
E
E
-----
13
PsiBlast_PDB
62.05
24%
-36
- C1 -
3EIX
1
?
A:
[12-282]
------------------------------------------------
D
E
-
N
-
G
-
T
V
K
V
P
K
D
--
A
K
R
I
V
--
V
L
E
--
Y
-
S
F
A
D
A
L
A
A
L
D
V
K
--
P
V
G
-
I
-
A
D
-
D
G
--
K
--
K
K
R
I
I
K
P
-
V
R
--
E
K
I
G
D
Y
T
S
V
G
-
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
K
------
G
I
N
K
E
L
N
-
K
I
-
A
P
T
L
S
L
K
----
S
---
F
----
D
-
G
D
Y
K
Q
N
I
N
S
F
K
T
I
A
K
A
L
N
K
E
--
K
E
G
E
K
R
L
A
E
H
D
K
---
L
I
N
K
Y
K
D
E
I
K
F
D
----
R
N
Q
---
K
V
L
P
A
V
V
A
K
--
A
G
L
L
A
H
-
P
N
Y
S
Y
V
G
Q
F
L
-
N
E
L
G
F
K
N
A
LS
D
D
--
V
T
-----
K
--------
G
L
S
K
Y
L
K
G
P
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
R
M
I
I
M
-
T
D
H
A
K
K
---
D
---
S
A
E
-
F
K
K
L
Q
E
D
A
T
----
W
K
K
L
N
A
V
K
N
N
R
V
-
D
I
-
V
D
R
D
------------
V
W
A
R
S
R
G
L
I
S
S
E
E
-----
23
HHSearch
61.37
25%
-41
- C1 -
3TNY
1
?
A:
[17-296]
------------------------------------
E
V
V
T
V
E
---
H
-
A
M
G
-
K
-
T
-
E
V
P
A
N
P
K
--
R
V
-
V
I
--
L
T
N
--
E
-
G
T
E
A
L
-
L
E
L
G
V
K
--
P
V
G
A
V
-
K
S
W
T
G
D-
P
--
W
Y
P
H
I
K
D
-
K
M
--
K
D
V
---
K
V
V
G
-
D
E
G
Q
V
N
V
E
T
I
A
S
L
K
P
D
L
I
I
G
N
K
M
R
-
H
E
------
K
V
Y
E
Q
L
K
-
A
I
-
A
P
T
V
F
S
E
----
T
---
L
----
R
-
G
E
W
K
D
N
F
---
K
F
Y
A
K
A
L
N
K
E
--
K
E
G
Q
K
V
V
A
D
Y
E
S
---
R
M
K
D
L
K
G
K
L
G
D
K
V
---
N
Q
E
---
I
S
M
-
V
R
F
M
P
--
G
D
V
R
I
Y
-
H
G
D
T
F
S
G
V
-
I
L
K
E
L
G
F
K
R
P
--
G
D
--
Q
N
-----
K
D-------
D
F
A
E
R
N
V
S
------
K
E
R
I
S
A
M
D
G
D
V
L
F
Y
F
T
F
D
K
G
N
E
---
K
K
--
G
S
E
L
E
K
E
Y
I
N
D
P
L
----
F
K
N
L
N
A
V
K
N
G
K
A
-
Y
K
-
V
D
D
V
I
W
NT-
A
--
G
G
V
I
A
A
N
L
L
--
L
D
D
I
E
K
R
F
V
--
12
PsiBlast_PDB
60.06
24%
-37
- C1 -
3LI2
6
?
A:
[12-282]
------------------------------------------------
D
E
-
N
-
G
-
T
V
K
V
P
K
D
--
A
K
R
I
V
--
V
L
E
--
Y
-
S
F
A
D
A
L
A
A
L
D
V
K
--
P
V
G
-
I
-
A
D
-
D
G
--
K
--
K
K
R
I
I
K
P
-
V
R
--
E
K
I
G
D
Y
T
S
V
G
-
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
K
------
G
I
N
K
E
L
N
-
K
I
-
A
P
T
L
S
L
K
----
S
---
F
----
D
-
G
D
Y
K
Q
N
I
N
S
F
K
T
I
A
K
A
L
N
K
E
--
K
E
G
E
K
R
L
A
E
H
D
K
---
L
I
N
K
Y
K
D
E
I
K
F
D
----
R
N
Q
---
K
V
L
P
A
V
V
A
K
--
A
G
L
L
A
H
-
P
N
Y
S
Y
V
G
Q
F
L
-
N
E
L
G
F
K
N
A
LS
D
D
--
V
T
-----
K
--------
G
L
S
K
Y
L
K
G
P
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
R
M
I
I
-
M
T
D
H
A
K
K
---
D
---
S
A
E
-
F
K
K
L
Q
E
D
A
T
----
W
K
K
L
N
A
V
K
N
N
R
V
-
D
I
-
V
D
R
D
------------
V
W
A
R
S
R
G
L
I
S
S
E
E
-----
39
HHSearch
59.74
26%
-44
- C1 -
3MWF
1
?
A:
[5-293]
-------------------------------------
T
T
S
I
K
---
H
-
A
M
G
-
T
-
T
-
E
I
K
G
K
P
K
--
R
V
-
V
T
--
L
Y
Q
--
G
-
A
T
D
V
A
-
V
S
L
G
V
K
--
P
V
G
A
V
-
E
S
-
W
T
QK
P
--
K
F
E
Y
I
K
N
-
D
L
--
K
D
T
---
K
I
V
G
-
Q
E
P
A
P
N
L
E
E
I
S
K
L
K
P
D
L
I
V
A
S
K
V
R
-
N
E
------
K
V
Y
D
Q
L
S
-
K
I
-
A
P
T
V
S
T
D
----
T
---
V
------
F
K
F
K
D
T
T
---
K
L
M
G
K
A
L
G
K
E
--
K
E
A
E
D
L
L
K
K
Y
D
D
---
K
V
A
A
F
Q
K
D
A
K
A
K
Y
KDA
W
P
L
---
K
A
S
V
V
N
F
R
A
--
D
H
T
R
I
Y
-
A
G
-
G
Y
A
G
E
-
I
L
N
D
L
G
F
K
R
N
--
K
D
--
L
Q
-----
K
Q
V
D
N
G---
K
D
I
I
Q
L
T
S
------
K
E
S
I
P
L
M
N
A
D
H
I
F
V
V
K
S
D
P
N
A
K
---
D
A
A
L
V
K
K
T
E
S
E
W
T
S
S
K
E
----
W
K
N
L
D
A
V
K
N
N
Q
V
-
S
D
D
L
D
E
I
T
W
NL-
A
--
G
G
Y
K
S
S
L
K
L
--
I
D
D
L
Y
E
K
L
N
I
-
25
HHSearch
57.80
19%
-42
* C1 *
3LHS
4
?
A:
[5-293]
-----------------------------------
A
S
T
I
S
V
K
---
D
-
E
N
G
-
T
-
V
-
K
V
P
K
D
A
K
--
R
I
-
V
V
--
L
E
Y
--
S
-
F
A
D
A
L
-
A
A
L
D
V
K
--
P
V
G
I
A
-
D
D
-
G
K
KK
R
--
I
I
K
P
V
R
E
-
K
I
--
G
D
Y
---
T
S
V
G
-
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
K
------
G
I
N
K
E
L
N
-
K
I
-
A
P
T
L
S
L
K
----
S
F--
D
G---
D
Y
K
Q
N
I
N
S
F
---
K
T
I
A
K
A
L
N
K
E
--
K
E
G
E
K
R
L
A
E
H
D
K
---
L
I
N
K
Y
K
D
E
I
K
F
D
----
R
N
Q
---
K
V
L
P
A
V
V
A
K
--
A
G
L
L
A
H
-
P
N
Y
S
Y
V
G
Q
-
F
L
N
E
L
G
F
K
N
A
--
L
S
--
D
D
-----
V
T
K
G
L
SKYL
K
G
P
Y
L
Q
L
D
------
T
E
H
L
A
D
L
N
P
E
R
M
I
I
M
T
D
H
A
K
K
--------
D
S
A
E
F
K
K
L
Q
E
D
A
T
----
W
K
K
L
N
A
V
K
N
N
R
V
-
D
I
-
V
D
R
D
V
W
AR-
S
--
R
G
L
I
S
S
E
E
M
--
A
K
E
L
V
E
L
S
K
K
-
9
PsiBlast_PDB
54.76
27%
-43
- C1 -
3GFV
1
YCLQ_BACSU
A:
[14-295]
-----------------------------------
K
E
Q
I
T
V
K
---
H
Q
L
D
K
-
N
---
G
T
K
V
P
K
N
PK
K
V
V
V
F
D
F
G
S
L
--
D
-
T
L
D
K
L
-
G
L
D
D
I
V
--
A
G
L
P
K
-
Q
V
-
L
P
--
K
--
Y
L
S
K
F
K
D
-----
D
K
Y
---
A
D
V
G
-
S
L
K
E
P
D
F
D
K
V
A
E
L
D
P
D
L
I
I
I
S
A
R
Q
-
S
E
S
Y
----
K
E
F
S
K
I
A
P
T
I
-
Y
L
G
V
D
T
A
----
K
---
Y
----
M
-
E
S
F
K
S
D
A
---
E
T
I
G
K
I
F
D
K
E
--
D
K
V
K
D
E
L
A
N
I
D
H
S
I
A
D
V
K
K
T
A
E
K
L
N
--------
K
---
N
G
L
V
I
M
A
N
D
--
G
K
I
S
A
F
G
P
K
S
R
Y
---
G
L
I
H
D
V
F
G
V
A
P
--
A
D
QN
I
K
-----
A
--------
S
T
H
G
Q
S
V
S
------
Y
E
Y
I
S
K
T
N
P
D
Y
L
F
V
-
I
D
R
G
T
A
I
---
G
---
E
T
S
S
T
K
Q
V
V
E
N
D
Y
----
V
K
N
V
N
A
V
K
N
G
H
V
I
Y
L
-
D
S
A
T
W
Y
---
L
--
S
G
G
G
L
E
S
M
T
Q
M
I
K
E
V
K
D
G
L
---
38
HHSearch
52.99
22%
-41
- C1 -
4JCC
5
?
A:
[3-285]
----------------------------------
A
P
T
E
V
T
I
K
---
S
-
S
L
D
-
E
-
V
-
K
L
S
K
V
P
E
--
K
I
-
V
T
--
F
D
L
--
G
-
A
A
D
T
I
-
R
A
L
G
F
A
KN
I
V
G
M
P
-
T
K
-
T
------
V
P
T
Y
L
K
D
-
L
V
--
G
T
V
---
K
N
V
G
-
S
M
K
E
P
D
L
E
A
I
A
A
L
E
P
D
L
I
I
A
S
P
R
T
--
Q
------
K
F
V
D
K
F
K
-
E
I
-
A
P
T
V
L
F
Q
----
A
---
S
KDD-
Y
W
T
S
T
K
A
N
I
---
E
S
L
A
S
A
F
G
E
T
G
T
Q
K
A
K
E
E
L
A
K
L
D
E
---
S
I
Q
E
V
A
T
K
N
E
S
-----
S
D
K
---
K
A
L
A
I
L
L
N
E
--
G
K
M
A
A
F
-
G
A
K
S
R
F
S
F
-
L
Y
Q
T
L
K
F
K
P
T
--
D
T
--
K
F
-----
E
D-------
S
R
H
G
Q
E
V
S
------
F
E
S
V
K
E
I
N
P
D
I
L
F
V
I
N
R
T
L
A
I
G
---
G
---
D
N
S
S
N
D
G
V
L
E
N
A
L
----
I
A
E
T
P
A
A
K
N
G
K
I
-
I
Q
-
L
T
P
D
L
W
Y
LS
G
--
G
G
L
E
S
T
K
L
M
--
I
E
D
I
Q
K
A
L
---
43
Fugue
52.57
18%
-45
- C1 -
2CHU
4
?
A:
[10-296]
---------------------------
L
P
I
S
M
S
D
E
G
D
S
F
L
V
K
---
D
-
S
L
G
-
E
-
N
-
K
I
P
K
N
P
S
--
K
V
V
I
L
---
D
L
--
G
-
I
L
D
T
F
-
D
A
L
K
L
N
--
D
K
V
V
G
-
V
P
-
A
K
--
N
--
L
P
K
Y
L
Q
Q
-
F
K
--
N
-
K
---
P
S
V
G
-
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
--
Q
S
------
K
F
Y
D
K
L
K
-
E
I
-
A
P
T
L
F
V
G
LDNA
N
---
F
----
L
-
S
S
F
E
N
N
V
---
L
S
V
A
K
L
Y
G
L
E
--
K
E
A
L
E
K
I
S
D
I
K
N
---
E
I
E
K
A
K
S
I
V
D
E
D
------
K
---
K
A
L
I
I
L
T
N
S
--
N
K
I
S
A
F
-
G
P
Q
S
R
F
-
G
I
I
H
D
V
L
G
I
N
A
V
--
D
E
------------------
N
I
K
G
K
S
I
N
------
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
-
V
D
R
N
V
I
L
---
G
---
N
K
E
R
A
Q
G
I
L
D
N
A
L
----
V
A
K
T
K
A
A
Q
N
K
K
I
-
I
Y
-
L
D
P
E
Y
W
YL-
A
--
S
G
N
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
K
--
7
PsiBlast_PDB
52.12
30%
-53
- C1 -
3MWF
1
?
A:
[38-262]
--------------------------------------------------------------------------------------
L
G
V
K
--
P
V
G
A
V
E
S
W
-
T
Q
--
K
PK
F
E
Y
I
K
N
D
-
L
K
--
D
-
T
---
K
I
V
G
-
Q
E
P
A
P
N
L
E
E
I
S
K
L
K
P
D
L
I
V
A
S
K
V
R
-
N
E
------
K
V
Y
D
Q
L
S
-
K
I
-
A
P
T
V
S
T
D
----
T
---
V
----
F
-
K
-
F
K
D
T
T
---
K
L
M
G
K
A
L
G
K
E
--
K
E
A
E
D
L
L
K
K
Y
D
D
---
K
V
A
A
F
Q
K
D
A
K
A
K
Y
---
K
D
A
WP
L
K
A
S
V
V
N
F
R
A
--
D
H
T
R
I
Y
-
A
G
G
--
Y
A
G
E
I
L
N
D
L
G
F
K
R
N
--
K
D
--
L
Q
K
Q
V
D
N
G
--------
K
D
I
I
Q
L
T
S
------
K
E
S
I
P
L
M
N
A
D
H
I
F
V
V
K
S
-
D
P
N
A
---
K
---
D
A
A
L
V
K
K
T
E
S
E
W
T
S
S
K
E
W
K
N
L
D
A
V
K
N
N
Q
V
--------------------------------------
36
HHSearch
51.69
20%
-46
- C1 -
3GFV
1
YCLQ_BACSU
A:
[14-297]
-----------------------------------
K
E
Q
I
T
V
K
---
H
-
Q
L
D
K
N
G
T
-
K
V
P
K
N
P
K
--
K
V
-
V
V
--
F
D
F
--
G
-
S
L
D
T
L
-
D
K
L
G
L
D
DI
V
A
G
L
P
-
K
Q
-
V
------
L
P
K
Y
L
-
S
-
K
F
KD
D
K
Y
---
A
D
V
G
-
S
L
K
E
P
D
F
D
K
V
A
E
L
D
P
D
L
I
I
I
S
A
R
Q
--
S
------
E
S
Y
K
E
F
S
-
K
I
-
A
P
T
I
Y
L
G
----
V
DTA
K
----
Y
M
E
S
F
K
S
D
A
---
E
T
I
G
K
I
F
D
K
E
--
D
K
V
K
D
E
L
A
N
I
D
H
---
S
I
A
D
V
K
K
T
A
E
K
L
N
-----
K
---
N
G
L
V
I
M
A
N
D
--
G
K
I
S
A
F
-
G
P
K
S
R
Y
G
L
-
I
H
D
V
F
G
V
A
P
A
--
D
Q
--
N
I
K----
A
--------
S
T
H
G
Q
S
V
S
------
Y
E
Y
I
S
K
T
N
P
D
Y
L
F
V
I
D
R
G
T
A
I
G
-------
E
T
S
S
T
K
Q
V
V
E
N
D
Y
----
V
K
N
V
N
A
V
K
N
G
H
V
-
I
Y
-
L
D
S
A
T
W
Y
LS
G
--
G
G
L
E
S
M
T
Q
M
--
I
K
E
V
K
D
G
L
E
K
-
22
HHSearch
51.66
18%
-45
- C1 -
4N01
6
?
A:
[41-333]
-----------------------------------
G
T
S
V
T
W
S
E
T
F
D
-
G
T
K
-
T
-
D
F
A
V
K
S
A
P
T
--
H
A
-
V
S
--
M
S
Q
--
A
-
T
T
E
M
M
-
L
Q
L
G
L
D
DK
M
A
G
T
A
-
F
K
-
E
E
--
E
--
I
Y
P
P
L
Q
A
-
A
Y
--
D
K
V
---
K
V
L
S
--
D
K
W
P
S
Y
E
V
F
M
S
V
K
P
D
F
A
T
G
W
P
D
S
F
S
K
RAIP
A
D
K
M
I
S
Q
K
V
-
N
I
W
I
P
E
S
M
L
S
----
T
K--
A
----
D
L
E
T
N
F
S
D
M
---
I
K
L
G
E
I
F
G
V
K
--
P
K
A
E
E
W
V
A
D
Q
R
K
---
T
L
A
A
I
Q
N
K
L
K
D
L
----
P
R
K
---
R
V
F
I
Y
D
S
E
D
--
G
Q
P
F
T
A
-
F
-
E
G
Y
T
T
N
-
I
L
K
L
I
G
A
D
N
V
--
M
S
--
G
L
-----
G
V-------
D
K
T
W
A
K
G
S
------
W
E
T
V
I
A
Q
N
P
D
Y
I
I
I
A
D
Y
G
N
S
I
R
ND
D
D
---
F
Q
Q
K
I
E
K
I
K
A
N
P
Q
----
L
Q
D
I
T
A
V
K
E
G
H
F
-
I
R
-
V
K
L
S
E
I
---
T
--
P
G
V
R
T
V
-
D
A
--
L
K
R
L
A
E
E
I
H
G
-
27
HHSearch
51.37
20%
-44
- C1 -
3TEF
-
?
A:
[51-329]
------------------------------------
E
T
V
T
I
E
---
H
-
R
L
G
-
K
-
T
-
T
L
E
Q
K
P
Q
--
R
V
-
V
V
--
I
G
V
--
G
-
A
L
D
A
I
-
D
S
F
G
I
E
--
P
V
A
V
S
-
K
F
-
D
G
-----
T
P
D
Y
L
A
K
Y
K
S
--
D
K
Y
---
P
S
A
G
-
S
L
F
E
P
D
F
E
T
I
Y
T
Q
K
P
D
L
I
V
I
G
P
R
A
--
S
------
K
S
Y
D
E
L
S
-
K
I
-
A
P
T
I
V
F
A
----
A
---
E
ADQG
Y
W
E
S
T
Q
Q
Q
W
---
R
N
L
G
K
V
F
A
I
E
--
P
A
V
E
A
K
I
E
Q
V
D
A
---
Q
F
K
S
I
M
Q
Y
N
Q
Q
-----
H
K
S
---
D
A
M
L
V
M
S
S
G
--
G
N
L
T
T
F
-
G
A
N
S
R
F
S
S
-
V
Y
K
D
F
G
F
S
E
T
--
V
P
--
V
S
-----
K
E-------
S
S
H
G
D
L
I
S
------
F
E
Y
I
R
E
H
N
P
K
T
L
L
V
V
D
R
D
K
V
V
T
---
K
---
G
E
T
N
I
R
Q
T
F
E
N
D
L
----
V
K
A
T
T
A
Y
K
N
G
H
I
-
A
Y
-
L
D
V
N
A
W
Y--
I
AI
S
G
V
K
A
T
E
Q
M
--
V
A
D
M
K
A
S
----
41
HHSearch
50.75
17%
-35
- C1 -
5AZ3
1
?
A:
[48-332]
-------------------------------
N
A
S
P
A
L
P
V
S
L
T
---
D
-
A
D
G
-
N
-
D
V
V
V
E
-
D
V
S
--
R
I
-
L
P
--
L
D
L
YG
T
-
Y
S
K
T
I
-
A
G
L
G
L
V
DN
I
V
G
R
T
-
V
S
-
S
T
--------
E
--
P
-
A
L
--
A
D
T
---
E
V
V
T
T
G
G
H
T
L
N
A
E
A
I
L
N
L
H
P
T
L
V
I
I
D
H
S
I
G
P
R
------
E
V
I
D
Q
I
R
-
A
A
G
V
A
T
V
I
M
S
----
P
Q--
R
----
S
I
A
S
I
G
D
D
I
---
R
D
I
A
S
V
V
G
L
P
--
E
E
G
E
K
L
A
E
R
S
V
A
---
E
V
E
E
A
S
T
V
V
D
E
L
T
PE-
D
P
L
---
K
M
V
F
L
Y
A
R
G
TG
G
V
F
F
I
L
-
G
D
A
Y
G
G
R
D
-
L
I
E
G
L
G
G
V
D
M
--
A
A
--
E
K
-----
G
--------
I
M
D
L
A
P
A
N
------
A
E
A
L
A
E
L
N
P
D
V
F
V
M
M
S
E
G
L
V
S
---------
T
G
G
I
D
G
L
M
E
R
P
G
----
I
A
Q
T
T
A
G
Q
N
Q
R
V
-
L
A
-
L
P
D
G
Q
S
L--
A
--
F
G
A
Q
T
G
-
E
L
--
L
L
R
A
S
R
E
L
Y
V
-