@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu01700: (2016-06-03 )
MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAAVQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGIMAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARKVGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMVKIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLKTSTDQKQAQTLLDEANGFIDKAIEHYHP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100....-...110.......120-...--....-..---130-........140-.-......150.......160......---.170----......-..180.......190.-----...-----...200.......210.......220.......230.......240.......250.......260..--------------------------.....270.......280.......290.......300..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEPL
N
L
H
R
LTTESRNS
Q
T
V
E
I
HKANT
L
G
I
L
K
MINNE
D
M
K
V
A
A
A
V
Q
E
V
L
P
D
I
K
T
A
V
D
C
A
Y
E
S
F
QNG
G
R
L
I
Y
TGAGTSGRLG
V
M
D
AVECPPTYSV
S
P
D
Q
V
I
G
I
MAG
G
-
P
E
A
F
L
Q
A
AEGIED
S
---
E
E
A--
G
A
E
D
-
L
R
---
N
I
--
Q
LTSND
T
V
I
A
I
-A-ASGRTP
Y
A
A
G
A
L
R
Y
A
R
KVG
A
H
T
I
A
L
---TCN-----ENSAIS-KDAD
H
S
I
E
V
V
VGPEAI-----TGS-----TRM
K
A
A
T
A
H
K
M
I
L
N
M
I
S
T
A
V
M
V
K
I
G
K
V
Y
EN
L
M
V
D
V
NVS
N
K
K
L
K
E
R
A
I
S
I
I
Q
S
L
TNASYDT
A
R
Y
T
L
E
QA--------------------------DHH
V
K
T
A
I
V
M
L
KTST
D
Q
K
Q
A
Q
T
L
L
D
EAN
G
F
I
D
K
A
I
E
HYHP
32
HHSearch
97.43
51%
-92
- C4 -
4S12
4
?
A:
[4-298]
----
M
K
L
G
A
L
I
S
E
S
R
N
P
D
T
M
D
L
D
T
L
S
T
L
E
M
L
T
R
I
N
D
E
D
R
K
V
P
E
A
I
R
L
V
I
P
N
I
A
Q
A
V
D
L
A
A
K
A
L
R
D
G
G
R
L
I
Y
L
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
P
H
G
R
V
I
G
L
I
A
G
G
-
P
G
A
L
L
K
A
V
E
G
A
E
D
D
---
V
S
L
--
G
E
R
D
-
L
R
---
D
L
--
Q
L
T
A
T
D
M
V
V
G
L
-
A
-
A
S
G
R
T
P
Y
V
I
G
A
L
R
F
A
R
Q
L
G
C
P
T
A
A
I
---
S
C
N
-----
P
D
S
P
I
A
-
Q
E
A
L
V
A
I
S
P
V
V
G
P
E
A
L
-----
T
G
S
-----
T
R
M
K
S
G
T
A
Q
K
L
V
L
N
M
L
S
T
G
A
M
V
K
L
G
K
V
Y
Q
N
L
M
V
D
V
K
A
T
N
V
K
L
V
D
R
A
C
R
I
V
V
E
A
T
G
A
S
R
V
E
A
E
N
A
L
S
Q
T
--------------------------
E
F
E
V
K
P
A
I
L
M
I
L
K
G
V
S
V
E
Q
A
R
L
N
L
Q
Q
H
N
G
Y
L
R
A
A
L
-----
1
PsiBlast_PDB
97.43
51%
-92
- C4 -
4S12
4
?
A:
[4-298]
----
M
K
L
G
A
L
I
S
E
S
R
N
P
D
T
M
D
L
D
T
L
S
T
L
E
M
L
T
R
I
N
D
E
D
R
K
V
P
E
A
I
R
L
V
I
P
N
I
A
Q
A
V
D
L
A
A
K
A
L
R
D
G
G
R
L
I
Y
L
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
P
H
G
R
V
I
G
L
I
A
G
G
-
P
G
A
L
L
K
A
V
E
G
A
E
D
D
---
V
S
L
--
G
E
R
D
-
L
R
---
D
L
--
Q
L
T
A
T
D
M
V
V
G
L
-
A
-
A
S
G
R
T
P
Y
V
I
G
A
L
R
F
A
R
Q
L
G
C
P
T
A
A
I
---
S
C
N
-----
P
D
S
P
I
A
-
Q
E
A
L
V
A
I
S
P
V
V
G
P
E
A
L
-----
T
G
S
-----
T
R
M
K
S
G
T
A
Q
K
L
V
L
N
M
L
S
T
G
A
M
V
K
L
G
K
V
Y
Q
N
L
M
V
D
V
K
A
T
N
V
K
L
V
D
R
A
C
R
I
V
V
E
A
T
G
A
S
R
V
E
A
E
N
A
L
S
Q
T
--------------------------
E
F
E
V
K
P
A
I
L
M
I
L
K
G
V
S
V
E
Q
A
R
L
N
L
Q
Q
H
N
G
Y
L
R
A
A
L
-----
21
PsiBlast_CBE
97.31
51%
-100
- C4 -
4S12
5
?
C:
[11-298]
-----------
S
E
S
R
N
P
D
T
M
D
L
D
T
L
S
T
L
E
M
L
T
R
I
N
D
E
D
R
K
V
P
E
A
I
R
L
V
I
P
N
I
A
Q
A
V
D
L
A
A
K
A
L
R
D
G
G
R
L
I
Y
L
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
P
H
G
R
V
I
G
L
I
A
G
G
-
P
G
A
L
L
K
A
V
E
G
A
E
D
D
---
V
S
L
--
G
E
R
D
-
L
R
---
D
L
--
Q
L
T
A
T
D
M
V
V
G
L
-
A
-
A
S
G
R
T
P
Y
V
I
G
A
L
R
F
A
R
Q
L
G
C
P
T
A
A
I
---
S
C
N
-----
P
D
S
P
I
A
-
Q
E
A
L
V
A
I
S
P
V
V
G
P
E
A
L
-----
T
G
S
-----
T
R
M
K
S
G
T
A
Q
K
L
V
L
N
M
L
S
T
G
A
M
V
K
L
G
K
V
Y
Q
N
L
M
V
D
V
K
A
T
N
V
K
L
V
D
R
A
C
R
I
V
V
E
A
T
G
A
S
R
V
E
A
E
N
A
L
S
Q
T
--------------------------
E
F
E
V
K
P
A
I
L
M
I
L
K
G
V
S
V
E
Q
A
R
L
N
L
Q
Q
H
N
G
Y
L
R
A
A
L
-----
2
PsiBlast_PDB
94.34
47%
-96
- C4 -
4LZJ
2
MURQ_HAEIN
A:
[11-301]
--------
T
L
I
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
-
E
C
A
I
R
H
P
V
E
G
A
E
D
N
---
T
K
A
--
V
L
N
D
-
L
Q
---
S
I
--
H
F
S
K
N
D
V
L
V
G
I
-
A
-
A
S
G
R
T
P
Y
V
I
A
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
---
A
S
N
-----
P
K
S
E
M
A
-
E
I
A
D
I
A
I
E
T
I
V
G
P
E
I
L
-----
T
G
S
-----
S
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
T
D
C
N
K
T
L
A
E
Q
T
L
L
E
A
--------------------------
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
K
V
L
L
E
R
H
Q
G
K
L
R
N
A
L
-----
3
PsiBlast_PDB
94.28
47%
-98
- C4 -
4M0D
-
MURQ_HAEIN
A:
[8-301]
-----
S
L
S
T
L
I
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
-
E
C
A
I
R
H
P
V
E
G
A
E
D
N
---
T
K
A
--
V
L
N
D
-
L
Q
---
S
I
--
H
F
S
K
N
D
V
L
V
G
I
-
A
-
A
S
G
R
T
P
Y
V
I
A
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
---
A
S
N
-----
P
K
S
E
M
A
-
E
I
A
D
I
A
I
E
T
I
V
G
P
E
I
L
-----
T
G
S
-----
S
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
T
D
C
N
K
T
L
A
E
Q
T
L
L
E
A
--------------------------
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
K
V
L
L
E
R
H
Q
G
K
L
R
N
A
L
-----
23
PsiBlast_CBE
94.16
47%
-96
- C4 -
4LZJ
2
MURQ_HAEIN
D:
[8-301]
-----
S
L
S
T
L
I
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
-
E
C
A
I
R
H
P
V
E
G
A
E
D
N
---
T
K
A
--
V
L
N
D
-
L
Q
---
S
I
--
H
F
S
K
N
D
V
L
V
G
I
-
A
-
A
S
G
R
T
P
Y
V
I
A
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
---
A
S
N
-----
P
K
S
E
M
A
-
E
I
A
D
I
A
I
E
T
I
V
G
P
E
I
L
-----
T
G
S
-----
S
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
T
D
C
N
K
T
L
A
E
Q
T
L
L
E
A
--------------------------
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
K
V
L
L
E
R
H
Q
G
K
L
R
N
A
L
-----
25
PsiBlast_CBE
93.61
47%
-95
- C4 -
4LZJ
2
MURQ_HAEIN
B:
[8-301]
-----
S
L
S
T
L
I
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
-
E
C
A
I
R
H
P
V
E
G
A
E
D
N
---
T
K
A
--
V
L
N
D
-
L
Q
---
S
I
--
H
F
S
K
N
D
V
L
V
G
I
-
A
-
A
S
G
R
T
P
Y
V
I
A
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
---
A
S
N
-----
P
K
S
E
M
A
-
E
I
A
D
I
A
I
E
T
I
V
G
P
E
I
L
-----
T
G
S
-----
S
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
T
D
C
N
K
T
L
A
E
Q
T
L
L
E
A
--------------------------
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
K
V
L
L
E
R
H
Q
G
K
L
R
N
A
L
-----
22
PsiBlast_CBE
93.61
51%
-96
- C4 -
4S12
3
?
B:
[7-298]
-------
G
A
L
I
S
E
S
R
N
P
D
T
M
D
L
D
T
L
S
T
L
E
M
L
T
R
I
N
D
E
D
R
K
V
P
E
A
I
R
L
V
I
P
N
I
A
Q
A
V
D
L
A
A
K
A
L
R
D
G
G
R
L
I
Y
L
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
P
H
G
R
V
I
G
L
I
A
G
G
-
P
-----
A
V
E
G
A
E
D
D
---
V
S
L
--
G
E
R
D
-
L
R
---
D
L
--
Q
L
T
A
T
D
M
V
V
G
L
-
A
-
A
S
G
R
T
P
Y
V
I
G
A
L
R
F
A
R
Q
L
G
C
P
T
A
A
I
---
S
C
N
-----
P
D
S
P
I
A
-
Q
E
A
L
V
A
I
S
P
V
V
G
P
E
A
L
-----
T
G
S
-----
T
R
M
K
S
G
T
A
Q
K
L
V
L
N
M
L
S
T
G
A
M
V
K
L
G
K
V
Y
Q
N
L
M
V
D
V
K
A
T
N
V
K
L
V
D
R
A
C
R
I
V
V
E
A
T
G
A
S
R
V
E
A
E
N
A
L
S
Q
T
--------------------------
E
F
E
V
K
P
A
I
L
M
I
L
K
G
V
S
V
E
Q
A
R
L
N
L
Q
Q
H
N
G
Y
L
R
A
A
L
-----
24
PsiBlast_CBE
93.05
47%
-94
- C4 -
4LZJ
2
MURQ_HAEIN
C:
[9-293]
------
L
S
T
L
I
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
-
E
C
A
I
R
H
P
V
E
G
A
E
D
N
---
T
K
A
--
V
L
N
D
-
L
Q
---
S
I
--
H
F
S
K
N
D
V
L
V
G
I
-
A
-
A
S
G
R
T
P
Y
V
I
A
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
---
A
S
N
-----
P
K
S
E
M
A
-
E
I
A
D
I
A
I
E
T
I
V
G
P
E
I
L
-----
T
G
S
-----
S
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
T
D
C
N
K
T
L
A
E
Q
T
L
L
E
A
--------------------------
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
K
V
L
L
E
R
H
-------------
34
HHSearch
72.13
23%
-100
- C4 -
4BB9
2
GCKR_HUMAN
A:
[290-604]
----------------------------
R
C
L
L
E
I
L
R
T
F
E
R
A
H
Q
V
T
Y
S
Q
S
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
T
T
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
G
D
-
H
S
D
M
F
N
Q
K
A
E
L
T
N
Q
GPQ
F
T
F
--
S
Q
E
D
-
F
L
T
SI
L
P
--
S
L
T
E
I
D
T
V
V
F
I
-
F
T
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
---
A
H
S
T
VGQT
L
P
I
P
L
K
-
K
L
F
P
S
I
I
S
-
I
T
W
P
L
L
F
FEY--
E
G
N
F
I
---
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
I
H
FPQPLS
D
D
I
R
A
AP
I
S
C
H
V
Q
V
A
HEK
E
Q
V
I
P
I
A
L
L
S
L
L
F
R
C
S
I
T
E
A
Q
A
H
L
A
A
A
P
-
S
V
C
E
A
V
R
S
A
--
11
PsiBlast_PDB
64.12
26%
-91
- C4 -
4BBA
1
GCKR_HUMAN
A:
[311-543]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
T
T
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
G
D
H
S
D
M
F
N
Q
K
A
E
L
T
N
Q
G
---
P
Q
F
T
F
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
-----
F
E
Y
E
G
N
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------
12
PsiBlast_PDB
63.95
26%
-99
- C4 -
4OLH
9
GCKR_HUMAN
A:
[323-555]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------------
F
TF
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
FEYEG
N
F
I
-----
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------
19
PsiBlast_PDB
63.29
26%
-102
- C4 -
4OHK
6
GCKR_HUMAN
A:
[323-555]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------------
F
TF
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
FEYEG
N
F
I
-----
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------
14
PsiBlast_PDB
63.23
26%
-92
- C4 -
4OHO
6
GCKR_HUMAN
A:
[323-555]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------------
F
TF
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
FEYEG
N
F
I
-----
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------
6
PsiBlast_PDB
62.73
26%
-95
- C4 -
4MSU
9
GCKR_HUMAN
A:
[322-554]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------------
F
TF
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
FEYEG
N
F
I
-----
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------
13
PsiBlast_PDB
62.68
26%
-96
- C4 -
4OHM
7
GCKR_HUMAN
A:
[323-555]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------------
F
TF
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
FEYEG
N
F
I
-----
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------
16
PsiBlast_PDB
62.65
26%
-94
- C4 -
4OP1
9
GCKR_HUMAN
A:
[323-555]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------------
F
TF
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
FEYEG
N
F
I
-----
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------
18
PsiBlast_PDB
62.56
26%
-97
- C4 -
4OP3
8
GCKR_HUMAN
A:
[323-555]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------------
F
TF
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
FEYEG
N
F
I
-----
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------
17
PsiBlast_PDB
62.40
26%
-93
- C4 -
4OP2
7
GCKR_HUMAN
A:
[323-555]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------------
F
TF
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
FEYEG
N
F
I
-----
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------
20
PsiBlast_PDB
62.35
26%
-100
- C4 -
4PXS
8
GCKR_HUMAN
A:
[323-555]
-------------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------------
F
TF
S
Q
E
D
F
L
T
---
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
-
L
D
D
N
L
T
E
V
Q
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
T
V
G
-----
Q
T
L
P
I
P
L
K
K
L
F
P
S
I
I
S
I
T
W
P
L
L
F
FEYEG
N
F
I
-----
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
G
Q
S
K
A
R
C
I
E
S
L
L
R
A
--------------------------
I
H
--------------------------------------