@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu02060: (2016-06-03 )
MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVLLAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVGMSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTIILMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIGITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKIGITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGTIAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKHPFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRTQANLTKSEQAAE
Atome Classification :
(20 SA)
--.........10------........20........30...--.....40........50..-......60..-----....-...-70........80...-..-...90......-..--100.---......110..----...----..-120---.---.----.---..---------....130.-..------....140......----.150..----------...--..160-----........170.-......180.......190.......200.......210.......220.......230...----------...-.240-----------..---.....250-........------.260-----.-..---....-270....------..--.----280..------....------.290.......300.......310.--------...----.----..320...-....330-.....-----....340-......-----.--.-350-------.--.....----..360.......---..---370-----...-....380....-------...390....---...----400.......410......-----.420.--......----430---.-----.-.....440.......450.......460-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MA
N
K
E
L
K
R
GLG------A
R
H
I
Q
M
I
A
LGG
T
I
G
V
G
L
F
MGSA
S
--
T
I
SWT
G
P
S
V
L
L
A
Y
A
I
C
G
I
F
-
I
F
F
I
M
R
A-MG-----
E
M
L
Y
-VEP-STG
S
F
A
T
F
G
H
Q
Y
I
H
P
-
M
A
-
G
Y
I
T
A
W
S
N
W
F
Q
-
W
I
--
I
V
G
M
---
S
E
I
I
A
VGSY
T
K
----
Y
WF----PD-L-----
P
---
A
----
W
---
I
P
---------
G
I
V
A
M
V
I
L-GA------A
N
L
I
S
V
KSFG
E
F
E
----
F
W
F
A
M
I
----------
K
I
V
--
T
I
I
L
------
M
I
I
AGI
G
I
I
F
F
G
-FGNGGDAI
G
L
S
N
L
WSHGGFFAG
G
F
S
G
F
F
F
A
L
S
L
V
I
A
A
YQG
V
E
L
I
G
I
TAGEAK
D
P
Q
N
T
L
R
N
A
I
----------
Q
S
I
-
I
W
R
I
-----------
L
I
---
F
Y
I
G
A
I
---
F
V
I
V
T
VY
P
------
W
D
E
L
-----
N
-SL---G
S
P
F
-
V
S
T
F
S
KI------
G
I
--
T
----
A
A
A
G
I
------
I
N
F
V
------
V
I
T
A
A
M
S
GCN
S
G
I
F
SAG
R
M
L
Y
T
LGV--------NGQ----A----
P
K
F
F
K
K
I
S-RNGVP---
L
Y
G
T
I
-----
A
V
L
I
G
L
--
A
V
G
V
V
L
-----N--Y-IA--------P--
P
K
I
F
V
----
Y
V
Y
--SASVLP
G
---
M
I
---
P
W
F
-----
I
I
L
-
I
S
HIGFRKAKG-------AALDKHPFKM---PF
A
----
P
F
T
N
Y
L
T
I
A
F
L
L
M
V
L
V
G
M
W-----FNDD
T
--
R
I
S
L
I
V
----
G
V
I
---
F
-----
L
-
A
L
V
V
I
S
Y
Y
V
F
GIGKRTQANLTKSEQAAE-------
1
PsiBlast_PDB
89.15
24%
-126
- C3 -
3L1L
2
ADIC_ECO57
A:
[7-388]
--------
A
H
K
V
G
------
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
S
-
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
-
Y
A
-----
K
M
S
F
-
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
-
C
W
--
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
----
P
I
-
L
K----
D
---
P
----
W
---
V
L
---------
T
I
T
C
V
V
V
L
-
W
I
------
F
V
L
L
N
I
V
G
----
P
----
K
M
I
T
R
V
----------
Q
A
V
--
A
T
V
L
------
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
M
A
---------------
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
---
R
N
V
P
----------
I
A
T
-
I
G
G
V
-----------
L
I
A
A
V
C
Y
V
L
S
T
---
T
A
I
M
G
M
I
P
------
N
A
A
L
-----
R
-
V
S
---
A
S
P
F
G
D
A
A
R
M
A
L
------
G
D
--
T
----
A
G
A
-
I
------
V
S
F
C
------
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
--------
D
G
L
----
F
----
P
P
I
F
A
R
V
N
-
K
A
G
T
P
---
V
A
G
L
I
-----
I
V
G
I
L
M
--
T
I
-
F
Q
L
-----
S
--
S
-
I
S
--------
P
NA
T
K
E
F
G
----
L
V
S
--
S
V
S
V
I
F
T
---
L
V
---
P
Y
L
Y
T
C
A
A
L
L
L
-
L
G
H
G
H
F
G
K
A
R
P
-------
A
Y
L
-----------------------------------------------------------------------------------------------------------
14
HHSearch
88.95
18%
-143
- C3 -
3L1L
2
ADIC_ECO57
A:
[7-435]
--------
A
H
K
V
G
------
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
S
-
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
-
Y
A
-----
K
M
S
F
-
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
-
C
W
--
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
----
P
I
-
L
K----
D
---
P
----
W
V
L
T
I
T
---------
C
V
V
V
L
W
I
F
-
V
L
------
L
N
I
V
G
P
K
M
I
T
R
V
Q
----
A
V
A
T
V
L
----------
A
L
I
--
P
I
V
G
------
I
A
V
F
G
W
F
W
F
R
G
---------
E
T
Y
M
A
-------------
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
----------
I
G
G
-
V
L
I
A
-----------
A
V
---
C
Y
V
L
S
T
---
T
A
I
M
G
M
I
P
------
N
A
A
L
-----
R
-
V
S
---
A
S
P
F
-
G
D
A
A
R
M
A
------
L
G
--
D
----
T
A
G
A
I
------
V
S
F
C
------
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
--------
D
G
L
----
F
----
P
P
I
F
A
R
V
N
-
K
A
G
T
P
---
V
A
G
L
I
-----
I
V
G
I
L
M
--
T
I
F
Q
L
S
-----
S
--
I
S
P
N
--------
A
--
T
K
E
F
G
----
L
V
S
--
S
V
S
V
I
F
T
---
L
V
---
P
Y
L
-----
Y
T
C
-
A
A
L
L
L
L
G
H
G
H
F
-------
G
K
--
A
R
P
A
-------
Y
----
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
------------
A
K
E
V
M
W
----
S
F
V
---
T
-----
L
-
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
-----------------
2
PsiBlast_PDB
88.01
25%
-121
- C3 -
3OB6
1
ADIC_ECOLI
A:
[5-388]
------
A
D
A
H
K
V
G
------
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
S
-
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
-
Y
A
-----
K
M
S
F
-
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
--
G
A
I
A
---
M
V
V
I
G
V
G
-
Y
L
S
----
Y
F
F
----
P
I
-
L
-----
K
---
D
P
L
V
L
T
---
I
T
---------
C
V
V
V
L
W
I
F
-
V
L
------
L
N
I
V
G
P
K
M
I
T
R
-----------
V
----------
Q
A
V
--
A
T
V
L
------
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
M
A
A
--
W
N
V
S
G
L
--
G
T
F
G
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
---
R
N
V
P
----------
I
A
T
-
I
G
G
V
-----------
L
I
A
A
V
C
Y
V
L
S
T
---
T
A
I
M
G
M
I
P
------
N
A
A
L
-----
R
-
V
S
---
A
S
P
F
G
D
A
A
R
M
A
L
------
G
D
--
T
----
A
G
A
-
I
------
V
S
F
C
------
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
--------
D
G
L
----
F
----
P
P
I
F
A
R
V
N
-
K
A
G
T
P
---
V
A
G
L
I
-----
I
V
G
I
L
M
--
T
I
-
F
Q
L
-----
S
--
S
-
I
S
--------
P
------
G
----
L
V
S
--
S
V
S
V
I
F
T
---
L
V
---
P
Y
L
Y
T
C
A
A
L
L
L
-
L
G
H
G
H
F
G
K
A
R
P
-------
A
Y
L
-----------------------------------------------------------------------------------------------------------
23
Fugue
87.92
16%
-140
* C3 *
3GIA
7
Y609_METJA
A:
[3-435]
------
L
K
N
K
K
L
S
------
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
--
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
-
Y
T
-----
K
L
G
A
-
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
-
T
G
A
L
S
I
L
L
W
M
S
-
Y
V
--
I
S
I
A
---
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
NAPI
N
T
-
F
-----
N
---
I
----
A
---
I
T
---------
E
I
G
I
V
A
F
F
-
T
A
------
L
N
F
F
G
S
K
A
V
G
R
A
E
----
F
F
I
V
L
V
----------
K
L
L
--
I
L
G
L
------
F
I
F
A
G
L
I
T
I
H
-------------
P
S
Y
V
I
P
D
-
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
----------
F
I
S
-
I
L
I
V
-----------
M
F
---
V
Y
V
G
V
A
---
I
S
A
I
G
N
L
P
------
I
D
E
L
-----
I
K
A
S
---
E
N
A
L
-
A
V
A
A
K
P
F
------
L
G
--
N
----
L
G
F
L
L
------
I
S
I
G
------
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
--------
D
G
E
----
L
----
P
E
F
F
E
R
K
V
W
F
K
S
T
E
---
G
L
Y
I
T
-----
S
A
L
G
V
L
--
F
A
L
L
F
---------------------
N
--
M
E
G
V
A
----
S
I
T
--
S
A
V
F
M
V
I
---
Y
L
-----------
F
V
I
-
L
S
H
Y
I
L
I
D
E
V
G
------------
G
R
K
E
I
---
V
I
F
----
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
-----
N
-------
R
F
V
F
Y
----
G
I
I
---
A
-----
T
-
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--------
3
PsiBlast_PDB
86.46
24%
-120
- C3 -
3LRB
-
ADIC_ECO57
A:
[6-388]
-------
D
A
H
K
V
G
------
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
S
-
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
-
Y
A
-----
K
M
S
F
-
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
-
C
W
--
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
----
P
I
-
L
-----
K
---
D
PL
V
L
T
---
I
T
---------
C
V
V
V
L
W
I
F
-
V
L
------
L
N
I
V
G
P
K
M
I
T
R
-----------
V
----------
Q
A
V
--
A
T
V
L
------
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
M
A
A
--
W
N
V
S
G
L
--
G
T
F
G
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
---
R
N
V
P
----------
I
A
T
-
I
G
G
V
-----------
L
I
A
A
V
C
Y
V
L
S
T
---
T
A
I
M
G
M
I
P
------
N
-------------------------------------
T
----
A
G
A
-
I
------
V
S
F
C
------
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
--------
D
G
L
----
F
----
P
P
I
F
A
R
V
N
-
K
A
G
T
P
---
V
A
G
L
I
-----
I
V
G
I
L
M
--
T
I
-
F
Q
L
-----
S
--
S
-
I
S
--------
P
NA
T
K
E
F
G
----
L
V
S
--
S
V
S
V
I
F
T
---
L
V
---
P
Y
L
Y
T
C
A
A
L
L
L
-
L
G
H
G
H
F
G
K
A
R
P
-------
A
Y
L
-----------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.72
24%
-123
- C3 -
3LRC
-
ADIC_ECO57
A:
[6-388]
-------
D
A
H
K
V
G
------
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
S
-
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
-
Y
A
-----
K
M
S
F
-
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
-
C
W
--
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
----
P
I
-
L
-----
K
---
D
PL
V
L
T
---
I
T
---------
C
V
V
V
L
W
I
F
-
V
L
------
L
N
I
V
G
P
K
M
I
T
R
-----------
V
----------
Q
A
V
--
A
T
V
L
------
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
M
A
A
--
W
N
V
S
G
L
--
G
T
F
G
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
---
R
N
V
P
----------
I
A
T
-
I
G
G
V
-----------
L
I
A
A
V
C
Y
V
L
S
T
---
T
A
I
M
G
M
I
P
------
N
-------------------------------------
T
----
A
G
A
-
I
------
V
S
F
C
------
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
--------
D
G
L
----
F
----
P
P
I
F
A
R
V
N
-
K
A
G
T
P
---
V
A
G
L
I
-----
I
V
G
I
L
M
--
T
I
-
F
Q
L
-----
S
--
S
-
I
S
--------
P
NA
T
K
E
F
G
----
L
V
S
--
S
V
S
V
I
F
T
---
L
V
---
P
Y
L
Y
T
C
A
A
L
L
L
-
L
G
H
G
H
F
G
K
A
R
P
-------
A
Y
L
-----------------------------------------------------------------------------------------------------------
12
HHSearch
83.29
18%
-128
- C3 -
3GIA
6
Y609_METJA
A:
[3-371]
------
L
K
N
K
K
L
S
------
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
--
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
-
Y
T
-----
K
L
G
A
-
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
-
N
I
I
T
G
A
L
S
I
L
L
W
M
S
-
Y
V
--
I
S
I
A
---
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
----
N
A
P
I
-----
N
T
F
N
I
----
A
---
I
T
---------
E
I
G
I
V
A
F
F
-
T
A
------
L
N
F
F
G
S
K
A
V
G
R
A
E
----
F
F
I
V
L
V
----------
K
L
L
--
I
L
G
L
------
F
I
F
A
G
L
I
T
I
H
------------
P
S
Y
V
I
--
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
----------
F
I
S
-
I
L
I
V
-----------
M
F
---
V
Y
V
G
V
A
---
I
S
A
I
G
N
L
P
------
I
D
E
L
-----
I
K
A
S
---
E
N
A
L
-
A
V
A
A
K
P
F
------
L
G
--
N
----
L
G
F
L
L
------
I
S
I
G
------
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
--------
D
G
E
----
L
----
P
E
F
F
E
R
K
V
-
W
F
K
S
T
----
E
G
L
Y
-----
I
T
S
A
L
G
--
V
L
F
A
L
L
-----
F
-------------------
N
M
E
----
G
V
A
--
S
I
T
S
A
V
F
---
M
V
---
I
Y
L
-----
F
V
I
-
L
S
H
Y
I
L
I
D
E
V
G
-------
G
-------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.48
22%
-122
- C3 -
3NCY
-
ADIC_SALTY
A:
[10-384]
-----------
V
G
------
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
---
L
A
A
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
A
L
S
M
V
-
Y
A
-----
K
M
S
S
-
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
-
C
W
--
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
----
P
I
-
L
-----
K
---
D
---------
P
---------
L
V
L
T
L
T
C
V
-
A
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
-----------
V
----------
Q
A
V
--
A
T
V
L
------
A
L
V
P
I
V
G
I
A
V
F
G
W
F
W
F
K
G
E
-------
W
N
V
S
G
M
--
N
T
F
G
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
---
R
N
V
P
----------
I
A
T
-
I
G
G
V
-----------
L
I
A
A
V
C
Y
V
L
S
T
---
T
A
I
M
G
M
I
P
------
N
A
A
L
-----
R
-
V
S
---
A
S
P
F
G
D
A
A
R
M
A
L
------
G
D
--
T
----
A
G
A
-
I
------
V
S
F
C
------
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
--------
D
G
L
----
F
----
P
P
I
F
A
R
------
T
P
---
V
A
G
L
-----------
L
--
I
V
G
V
L
M
T
I
F
Q
F
S
--
S
-
M
S
--------
P
NA
A
K
E
F
G
----
L
V
S
--
S
V
S
V
I
F
T
---
L
V
---
P
Y
L
Y
T
C
A
A
L
L
L
-
L
G
H
G
H
F
G
K
A
R
----------------------------------------------------------------------------------------------------------------------
25
Fugue
77.05
14%
-130
- C3 -
4DJK
-
GADC_ECOLI
A:
[12-501]
----------
Q
L
T
------
L
L
G
F
F
A
I
T
A
S
M
V
M
A
V
Y
E
Y
P
T
F
A
T
--
S
-----
G
F
S
L
V
F
F
L
L
L
G
G
I
-
L
W
F
I
P
V
G
-
L
C
-----
A
A
E
M
-
A
T
V
-
D
G
W
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
F
A
A
I
S
F
G
Y
L
Q
-
I
A
--
I
G
-
F
---
I
P
M
L
Y
F
V
L
G
A
L
----
S
Y
I
----
L
K
-
W
-----
P
---
A
----
L
------------------------
N
------
E
D
P
I
T
K
T
I
A
A
L
I
I
----
L
W
A
L
A
L
----------
T
Q
F
GG
T
K
Y
T
------
A
R
I
A
K
V
G
F
F
A
G
I
-
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
T
F
F
P
D
F
S
K
V
G
T
L
V
V
F
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
----------
L
L
L
-
M
V
A
A
-----------
I
C
---
L
S
S
V
G
G
---
L
S
I
A
M
V
I
P
------
G
N
E
I
-------
N
L
---
S
A
G
V
-
M
Q
T
F
T
V
L
M
SHVAP
E
I
--
E
----
W
T
V
R
V
------
I
S
A
L
------
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
--------
K
N
L
----
L
----
P
A
A
F
A
K
M
N
-
K
N
G
V
P
V
T
L
V
I
S
Q
L
-----
V
I
T
S
I
A
--
L
I
I
L
T
N
-----
T
--
G
-
G
G
--------
N
--
N
M
S
F
L
----
I
A
L
--
A
L
T
V
V
I
Y
---
L
C
---
A
Y
F
-----
M
L
F
-
I
G
Y
I
V
L
V
L
K
H
P
-------
D
L
K
R
T
F
N
I
P
G
---
G
K
G
----
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
----
F
L
P
P
D
--
N
I
Q
G
D
S
----
T
D
M
---
Y
-----
V
-
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
RSP----
28
Fugue
76.99
19%
-121
- C1 -
4Z2T
1
?
A:
[11-591]
--
A
E
T
D
V
L
I
V
G
A
G
------
P
A
G
A
M
S
A
T
L
L
A
S
L
G
I
R
S
L
M
I
N
R
W
--
R
S
T
S
P
G
P
R
S
H
----
I
I
N
Q
R
-
T
M
E
I
L
R
D
-
I
G
L
E
E
S
A
K
S
L
A
-
V
P
K
-
E
Y
M
G
E
H
V
Y
A
T
S
L
A
G
E
-
E
F
-
G
R
I
P
A
W
A
S
H
--------
P
Q
A
---
H
A
E
H
E
L
A
S
P
S
R
----
Y
C
D
----
L
P
-
Q
-----
L
---
Y
----
F
---
E
P
---------
M
V
V
S
E
A
A
L
R
G
A
------
D
V
R
F
L
T
E
Y
L
G
H
V
E
D
QD
G
V
T
A
R
L
L
D
HVSG
A
E
Y
E
V
R
A
K
--
Y
I
I
G
ADGAHS
L
V
A
Q
N
A
G
L
P
F
E
G
-
Q
M
G
G
S
I
N
I
E
F
S
A
D
L
S
S
L
C
E
H
R
K
G
D
M
Y
Y
M
F
V
A
A
L
R
M
I
R
P
W
N
K
W
I
C
V
W
G
E
I
T
K
E
E
A
K
K
I
I
H
E
I
I
GTDEI
P
V
E
V
G
P
I
S
-
T
W
T
I
N
Q
Q
Y
A
VRNTSG
R
V
---
F
C
M
G
D
A
---
V
H
R
H
T
P
M
G
------
G
L
G
L
-----
N
-
T
S
---
V
Q
D
A
-
Y
N
L
A
W
K
L
------
A
L
--
V
L
K
GT
A
A
P
T
L
------
L
D
S
Y
D
A
E
R
S
P
V
A
K
Q
I
V
E
R
A
F
K
S
L
S
T
F
P
P
V
F
E
A
L
S
L
PPAPT
E
S
E
M
A
E
----
A
----
L
V
R
L
K
D
A
S
-
E
E
G
A
K
---
R
R
A
A
L
R
K
A
M
D
A
T
I
I
G
L
GG
G
H
G
V
E
L
-----
N
Q
R
Y
-
V
S
RAVFPDGT
P
--
D
P
G
F
V
RDQE
F
F
Y
--
Q
A
S
T
R
P
G
---
A
H
L
P
H
V
W
L
-----
T
E
N
-
Q
R
R
I
S
T
L
D
L
C
G
KG
R
F
T
L
L
T
G
L
S
G
A
A
W
K
H
---
E
A
E
----
Q
V
S
Q
S
L
G
I
E
L
K
V
C
V
I
G
P
G
Q
EFVDT
Y
G
E
Y
A
--
K
I
S
E
I
G
----
E
S
G
---
A
-----
L
-
L
V
R
P
D
M
F
I
A
F
R
A
K
D
A
S
R
E
G
L
E
Q
L
N
V
A
V
K
S
I
L
GR--
13
HHSearch
76.39
16%
-143
- C3 -
4DJK
-
GADC_ECOLI
A:
[12-457]
----------
Q
L
T
------
L
L
G
F
F
A
I
T
A
S
M
V
M
--
A
V
Y
E
Y
P
----
T
F
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
C
-
A
A
-----
E
M
A
T
-
V
D
G
W---
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
F
A
A
I
S
F
G
Y
L
Q
-
I
A
--
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
----
K
W
-----
P
A
-
L
NEDP
I
T
---
K
----
T
---
I
A
---------
A
L
I
I
L
W
A
L
-
A
L
------
T
Q
F
G
G
T
K
Y
T
A
R
I
A
----
K
V
G
F
F
A
----------
G
I
L
--
L
P
A
F
------
I
L
I
A
L
A
A
I
Y
L
H
------------------
T
F
F
P
D
F
S
K
V
G
T
L
V
V
F
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
----------
L
L
L
-
M
V
A
A
-----------
I
C
---
L
S
S
V
G
G
---
L
S
I
A
M
V
I
P
------
G
N
E
I
-----
N
-
L
S
A
G
V
M
Q
T
F
-
T
V
L
M
S
H
V
------
A
P
EI
E
----
W
T
V
R
V
------
I
S
A
L
------
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
--------
K
N
L
----
L
----
P
A
A
F
A
K
M
N
-
K
N
G
V
P
---
V
T
L
V
I
-----
S
Q
L
V
I
T
--
S
I
A
L
I
I
-----
L
T
-
N
-
T
G
--------
G
--
G
N
N
M
S
----
F
L
I
A
L
A
L
T
V
V
I
Y
---
L
C
---
A
Y
F
-----
M
L
F
-
I
G
Y
I
V
L
V
L
K
H
P
-------
D
L
--
K
R
T
F
N
I
---
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
-----
L
P
----------------------------------------------------------------
27
Fugue
70.69
20%
-171
- C4 -
5EGS
3
ANM6_HUMAN
A:
[40-376]
---
T
K
R
E
R
D
Q
L
Y
Y
E
C
Y
SD
V
S
V
H
E
E
M
I
A
D
R
V
R
T
D
A
Y
R
L
G
I
L
R
N
--
W
A
A
L
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
-
S
I
F
C
A
Q
A
-
G
A
-----
R
R
V
Y
A
V
E
A
-
S
A
----------
I
W
Q
-
Q
A
-
R
E
V
V
R
F
N
G
L
E
D
-
R
V
--
H
V
L
P
---
G
P
V
E
T
V
-----------------
E
-
L
-----
P
---
E
----
Q
---
V
D
---------
A
I
V
S
E
---------------------------------------------------------------------
W
M
G
-
Y
G
----------
L
L
H
E
S
------------
M
L
S
S
V
L
H
A
R
T
K
W
---------------------------------
L
-
K
E
G
G
-----------
L
L
---
L
P
A
S
A
E
---
L
F
I
V
P
I
S
--------
D
Q
M
-----
L
-
E
W
---
R
L
G
F
-
W
S
Q
V
K
Q
H
Y-----
G
V
--
D
----
M
-----------------------
S
C
L
E
G
F
A
T
R
C
L
M
G
H
S
E
I
V
V
Q
G
L
--------
S
G
E
----
D
VLAR
P
Q
R
F
A
Q
L
E
-
L
S
R
A
G
---
L
E
Q
E
L
-----
E
A
G
V
G
--------------------------------
G
R
F
R
C
----
S
C
Y
--
G
S
A
P
M
H
G
---
F
A
---
I
W
F
-----
Q
V
T
-
F
P
G
------------------
G
E
K
P
L
V
L
S
TS
P
F
H
----
P
A
T
H
W
K
Q
A
L
L
Y
L
N
E
P
V
Q
V
E
-----
Q
D
T
D
V
S
G
E
I
T
L
L
P
----
S
R
D
---
N
-----
P
R
R
L
R
V
L
L
R
Y
K
V
G
D
Q
E
E
K
T
K
D
F
A
M
E
D
-----------
30
Fugue
68.71
18%
-172
* C4 *
4QPP
3
ANM6_HUMAN
A:
[48-376]
--
Y
Y
E
C
Y
S
D
V
S
V
H
------
E
E
M
I
A
D
R
V
R
T
D
A
Y
R
L
G
I
L
R
N
W
A
A
--
L
---
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
-
S
I
F
C
A
Q
A
-
G
A
-----
R
R
V
Y
-
A
V
E
-
A
S
A
---------
I
W
Q
-
Q
A
-
R
E
V
V
R
F
N
G
L
E
D
-
R
V
--
H
V
L
P
---
G
P
V
E
T
V
-----------------
E
-
L
-----
P
---
E
----
Q
---
V
D
---------
A
I
V
S
E
--------------------------------------------------------------------------------------
W
M
G
Y
G
L
L
H
E
S
M
------
L
S
S
V
L
H
A
R
T
K
W
---------------------------------
L
-
K
E
G
G
-----------
L
L
---
L
P
A
S
A
E
---
L
F
I
V
P
I
S
--------
D
Q
M
-----
L
-
E
W
---
R
L
G
F
-
W
S
Q
V
K
Q
H
Y-----
G
V
--
D
----
M
-----------------------
S
C
L
E
G
F
A
T
R
C
L
M
G
H
S
E
I
V
V
Q
G
L
--------
S
G
E
DVLA
R
----
P
Q
R
F
A
Q
L
E
-
L
S
R
A
G
---
L
E
Q
E
L
-----
E
A
G
V
G
--------------------------------
G
R
F
R
C
----
S
C
Y
--
G
S
A
P
M
H
G
---
F
A
---
I
W
F
-----
Q
V
T
-
F
P
----------------
G
G
E
S
E
K
P
L
V
L
S
TS
P
F
H
----
P
A
T
H
W
K
Q
A
L
L
Y
L
N
E
P
V
Q
V
-------
E
Q
D
T
--
D
V
S
G
E
I
----
T
L
L
---
P
S
RDNP
R
-
R
L
R
V
L
L
R
Y
K
V
G
D
Q
E
E
K
T
K
D
F
A
M
E
D
-----------
29
Fugue
60.50
13%
-147
* C2 *
4HU8
3
?
A:
[3-452]
-----
N
E
I
T
L
T
I
G
----------
Q
Q
K
D
L
A
S
M
V
P
-
A
K
F
A
G
Q
E
L
--
S
W
T
S
S
D
P
E
T
A
S
V
T
D
K
-
G
I
V
-
T
A
L
K
F
S
S
-
G
G
-----
A
N
L
F
-
L
K
A
-
P
A
T
G
E
A
I
I
T
V
T
A
-
G
K
-
Q
S
-
H
S
V
K
V
I
T
T
--------
V
K
G
K
---
E
D
I
E
K
L
P
P
L
K
D
----
H
F
K
----
D
Y
-
F
------------------------------
L
I
G
N
I
F
N
-
N
R
------
D
V
S
G
S
M
M
D
N
D
W
L
A
----
H
H
Y
A
I
L
T
PENHM----
K
P
S
--
N
L
T
N
------
N
R
N
E
T
T
G
E
I
T
Y
T
-
F
---
S
T
A
D
R
M
V
N
A
A
I
A
E
G
L
K
I
H
G
H
T
L
L
W
H
Q
-----------
Q
I
P
P
W
Q
R
S
M
E
S
A
A
K
D
A
A
L
S
V
M
----------
K
K
Y
-
I
T
E
V
-----------
M
T
---
H
Y
K
G
K
I
YSW
D
V
L
N
E
I
F
P
DGRGDN
W
T
T
A
-----
M
-
R
P
---
E
N
P
W
-
F
K
S
I
G
S
D
------
F
V
--
Y
----
E
A
Y
L
A
------
A
R
Q
A
------
D
P
N
A
I
L
Y
Y
N
D
Y
N
M
D
Q
A
G
K
A
A
L
I
A
A
M
--------
V
R
D
----
V
----
N
A
K
Y
K
Q
A
Y
-
P
R
E
T
R
---
L
----------
L
I
E
G
I
--
G
M
Q
S
H
H
-----
N
--
M
-
D
V
--------
P
--
A
S
N
I
R
----
N
T
I
--
N
R
Y
R
E
L
G
V
K
I
S
V
---
S
E
L
-----
D
I
L
C
M
G
W
S
A
F
R
G
S
T
G
-------
Q
G
A
D
K
--
D
D
M
---
T
I
A
----
T
N
R
N
I
L
D
Q
A
Y
K
F
N
E
Y
M
K
L
Y
-----
L
E
N
S
D
--
I
I
E
R
V
S
M
WGV
S
D
R
---
Y
-----
S
-
W
R
S
G
G
L
P
L
L
F
D
A
D
N
K
A
K
P
A
Y
Y
S
F
V
R
A
R
E
D
Y
E
A
A
K
A
32
Fugue
60.20
18%
-128
- C2 -
4MUO
-
YBIB_ECOLI
A:
[1-320]
--
M
D
Y
R
K
I
I
K
E
I
G
------
R
G
K
----------------
N
H
A
R
--
D
L
D
R
D
T
A
R
G
L
Y
A
H
M
L
N
G
E
V
-
P
D
L
E
L
G
G
-
V
L
-----
I
A
L
R
-
I
K
G
-
E
G
----------
E
A
E
-
M
L
-
G
F
Y
E
A
M
Q
N
H
T
I
-
K
L
T
P
P
A
G
K
---
P
M
P
I
V
I
P
S
Y
N
------------------------------------------------------
G
A
------
R
K
Q
A
N
-----------------------------
L
T
--
P
L
L
A
------
I
L
L
H
K
L
G
F
P
V
V
V
-
H
G
V
S
E
D
P
T
R
-------------------------
V
L
T
E
T
I
F
E
L
M
G
I
T
P
T
L
H
G
G
Q
A
Q
A
K
L
D
E
H
----------
Q
P
V
-
F
M
P
-------------------------------------------
V
-----
G
-
A
F
---
C
P
P
L
-
E
K
Q
L
A
M
-----------
R
----
W
R
M
G
V
------
R
N
S
A
------
H
T
L
A
K
L
A
T
----
P
F
A
E
G
E
A
L
R
L
S
S
V
--------
S
H
----------
P
E
Y
I
G
R
V
A
-
K
F
F
S
D
---
I
G
G
R
A
-----
L
L
M
H
G
T
--
E
G
E
V
Y
A
-----
N
------------------------------------
P
Q
---
R
C
---
P
-
Q
-----
I
N
L
-
I
D
R
E
G
M
R
V
L
Y
E
---------------
K
Q
---
A
K
D
----
P
E
T
T
A
Q
W
I
E
R
C
L
-------------
A
G
S
E
--
P
I
P
E
S
L
----
K
I
Q
---
M
-----
A
-
C
C
L
V
A
T
----
G
E
A
A
T
I
S
D
G
L
A
R
V
N
Q
A
F
--------
26
Fugue
59.57
15%
-188
- C4 -
5E8R
14
ANM6_HUMAN
B:
[41-375]
KR
E
R
D
Q
L
Y
Y
E
C
Y
S
------
D
V
S
V
H
E
E
M
I
A
D
R
V
R
T
D
A
Y
R
L
G
I
L
R
N
W
A
A
L
R
G
K
T
V
L
D
V
G
A
G
T
G
I
L
-
S
I
F
C
A
Q
A
G
A
R
-----
R
V
Y
A
-
V
E
A
-
S
A
------------------------------
I
--
W
Q
Q
A
---
R
E
V
V
R
F
N
G
L
E
D
----
R
------------------------------------------
V
H
V
L
P
-
G
P
------
V
E
T
V
E
L
P
E
Q
--------------------------
V
--
D
A
I
V
------
S
E
W
M
G
Y
G
L
L
H
E
S
-
M
-----------------------------
L
S
S
V
L
H
A
R
T
K
W
L
K
E
G
---------------------------
G
L
L
-
L
P
A
S
-----------
A
E
---
L
F
I
V
P
I
S
D
Q
M
L
E
W
R
L
G
F
------
W
S
Q
V
-----
K
-
Q
H
---
Y
G
V
D
-
M
S
C
L
E
G
F
------
A
T
--
R
----
C
L
M
G
H
------
S
E
I
V
------
V
Q
G
L
S
G
E
D
V
L
A
R
---------------------------------
P
Q
R
F
A
Q
L
E
-
L
S
R
A
G
---
L
E
Q
E
L
-----
E
A
G
V
G
--------------------------------
G
R
F
R
C
----
S
C
Y
--
G
S
A
P
M
H
G
---
F
A
---
I
W
F
-----
Q
V
T
-
F
P
G
------------------
G
E
K
P
L
V
L
S
TS
P
F
H
----
P
A
T
H
W
K
Q
A
L
L
Y
L
N
E
P
V
Q
V
E
-----
Q
D
T
D
V
--
S
G
E
I
T
L
----
L
P
S
RDN
P
-----
R
-
R
L
R
V
L
L
R
Y
K
V
G
D
Q
E
E
K
T
K
D
F
A
M
E
------------
8
PsiBlast_PDB
59.27
23%
-120
- C3 -
3GI8
-
Y609_METJA
C:
[91-314]
------------------------------------------------------------------------------------------------------------------------
I
--
L
L
W
M
---
S
Y
V
I
S
I
A
L
F
A
K
GFAG
Y
F
L
----
P
L
-
I
-----
N
---
A
----
P
---
I
N
TFNIAITEI
G
I
V
A
F
--
F
-
T
A
------
L
N
F
F
G
S
K
A
V
G
R
A
E
----
F
F
I
V
L
V
----------
A
L
L
--
I
L
G
L
------
F
I
F
A
G
L
--------------
I
T
I
H
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
----------
F
I
S
-
I
L
I
V
-----------
M
F
---
V
Y
V
G
V
A
---
I
S
A
I
G
N
L
P
------
I
D
E
L
IKASE
N
-
A
L
AVA
A
K
P
F
-
L
G
N
L
G
F
L
------
L
I
--
S
----
I
G
A
----------
L
F
------
S
I
S
S
A
M
---
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
--------
D
G
E
----
L
----
P
E
F
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.65
23%
-121
- C3 -
3GIA
4
Y609_METJA
A:
[91-314]
------------------------------------------------------------------------------------------------------------------------
I
--
L
L
W
M
---
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
-
I
-----
N
---
A
----
P
---
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
--
F
-
T
A
------
L
N
F
F
G
S
K
A
V
G
R
A
E
----
F
F
I
V
L
V
----------
K
L
L
--
I
L
G
L
------
F
I
F
A
G
L
--------------
I
T
I
H
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
----------
F
I
S
-
I
L
I
V
-----------
M
F
---
V
Y
V
G
V
A
---
I
S
A
I
G
N
L
P
------
I
D
E
L
I
K
A
SE
N
-
A
L
A
V
A
A
K
P
F
-
L
G
N
L
G
F
L
------
L
I
--
S
----
I
G
A
----------
L
F
------
S
I
S
S
A
M
---
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
--------
D
G
E
----
L
----
P
E
F
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.04
23%
-117
- C3 -
3GI9
-
Y609_METJA
C:
[91-314]
------------------------------------------------------------------------------------------------------------------------
I
--
L
L
W
M
---
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
-
I
---------
A
----
P
---
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
--
F
-
T
A
------
L
N
F
F
G
S
K
A
V
G
R
A
E
----
F
F
I
V
L
V
----------
K
L
L
--
I
L
G
L
------
F
I
F
A
G
L
--------------
I
T
I
H
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
----------
F
I
S
-
I
L
I
V
-----------
M
F
---
V
Y
V
G
V
A
---
I
S
A
I
G
N
L
P
------
I
D
E
L
I
K
A
SE
N
-
A
L
A
V
A
A
K
P
F
-
L
G
N
L
G
F
L
------
L
I
--
S
----
I
G
A
----------
L
F
------
S
I
S
S
A
M
---
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
--------
D
G
E
----
L
----
P
E
F
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
43.52
23%
-70
- C3 -
4DJI
-
GADC_ECOLI
A:
[211-359]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
----------
L
L
L
M
V
A
A
I
-----------
C
L
---
S
S
V
G
G
L
----
S
I
A
M
V
I
P
------
G
N
E
I
-----
N
--
L
---
S
A
G
V
-
M
Q
T
F
T
V
L
------
M
S
--
H
----
V
A
P
E
I
EW
T
V
R
V
I
S
A
L
------
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
--------
K
N
L
----
L
----
P
A
A
F
A
K
M
N
-
K
N
G
V
P
---
V
T
L
V
I
-----
S
Q
L
V
I
T
--
S
I
A
L
I
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------