@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu02100: (2016-06-03 )
MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVKERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSREREMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQSLHYSLARMPSLPESGFVMSGIRRKS
Atome Classification :
(22 SA)
.........10........20........30....-....40...-......50........60........70........80........90........100.......110.......120.......130.......140.......150........160.......170...---....180.----......190.......200.......210.......220.-......230.......240.......250.......260.......270.-......280.......290.......300.......310.......320.......330.......340.......350...----....360.......370.......380.......390.......400.......410.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNEQIPHDKSLD
N
S
L
T
L
L
KE
G
Y
L
F
I
KN
R
T
E
RYN
S
D
-
L
F
Q
A
R
-LLG-K
N
F
I
C
MTGA
E
A
A
K
V
F
YD
T
D
R
F
Q
R
QNA
L
P
K
R
V
Q
K
S
LFGVNAIQGMDG
S
A
H
I
H
R
K
M
L
F
L
SLMTP
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
WEKAD
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
WA-GVPL
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
GA---VGPRHWKG----RRARP
R
A
E
E
W
I
E
V
M
I
E
D
ARAG
L
L
KTTSGT
A
L
H
E
M
AFHTQE-D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
LHEHP
K
Y
K
E
W
L
RSGN
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
YYP
F
G
P
F
L
G
A
L
V
K
K
D
FVWNNCEFKKG
T
S
V
L
L
D
L
YGTNHDPRLWDH
P
D
EF
R
P
E
R
F
A
E
R
E
E
N
L
F
D
MIPQGGG----HAEKGHRCPGE
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
EYDV
P
E
Q
S
L
H
Y
S
L
A
RMPSLPESGF
V
M
SGIRRKS
2
PsiBlast_PDB
95.85
100%
-107
- C4 -
2ZQX
1
CYPC_BACSU
A:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
25
PsiBlast_CBE
94.96
100%
-99
- C4 -
1IZO
2
CYPC_BACSU
C:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
26
PsiBlast_CBE
94.78
100%
-102
- C4 -
1IZO
2
CYPC_BACSU
B:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
22
PsiBlast_CBE
94.67
100%
-102
- C4 -
2ZQX
1
CYPC_BACSU
B:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
89
Fugue
94.37
100%
-98
- C4 -
1IZO
2
CYPC_BACSU
A:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
3
PsiBlast_PDB
94.33
100%
-102
- C4 -
2ZQJ
1
CYPC_BACSU
A:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
21
PsiBlast_CBE
94.13
100%
-102
- C4 -
2ZQX
1
CYPC_BACSU
C:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
1
PsiBlast_PDB
94.12
100%
-98
* C4 *
1IZO
2
CYPC_BACSU
A:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
23
PsiBlast_CBE
94.09
100%
-102
- C4 -
2ZQJ
1
CYPC_BACSU
C:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
24
PsiBlast_CBE
93.71
100%
-98
- C4 -
2ZQJ
1
CYPC_BACSU
B:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
N
S
-
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
99
HHSearch
91.49
100%
-99
- C4 -
1IZO
2
CYPC_BACSU
A:
[6-416]
-----
P
H
D
K
S
L
D
N
S
L
T
L
L
K
E
G
Y
L
F
I
K
N
R
T
E
R
Y
N
S
D
-
L
F
Q
A
R
-
L
L
G
-
K
N
F
I
C
M
T
G
A
E
A
A
K
V
F
Y
D
T
D
R
F
Q
R
Q
N
A
L
P
K
R
V
Q
K
S
L
F
G
V
N
A
I
Q
G
M
D
G
S
A
H
I
H
R
K
M
L
F
L
S
L
M
T
P
P
H
Q
K
R
L
A
E
L
M
T
E
E
W
K
A
A
V
T
R
W
E
K
A
D
E
V
V
L
F
E
E
A
K
E
I
L
C
R
V
A
C
Y
W
A
-
G
V
P
L
K
E
T
E
V
K
E
R
A
D
D
F
I
D
M
V
D
A
F
G
A
---
V
G
P
R
H
W
K
G
----
R
R
A
R
P
R
A
E
E
W
I
E
V
M
I
E
D
A
R
A
G
L
L
K
T
T
S
G
T
A
L
H
E
M
A
F
H
T
Q
E
-
D
G
S
Q
L
D
S
R
M
A
A
I
E
L
I
N
V
L
R
P
I
V
A
I
S
Y
F
L
V
F
S
A
L
A
L
H
E
H
P
K
Y
K
E
W
L
R
S
G
-
N
S
R
E
R
E
M
F
V
Q
E
V
R
R
Y
Y
P
F
G
P
F
L
G
A
L
V
K
K
D
F
V
W
N
N
C
E
F
K
K
G
T
S
V
L
L
D
L
Y
G
T
N
H
D
P
R
L
W
D
H
P
D
E
F
R
P
E
R
F
A
E
R
E
E
N
L
F
D
M
I
P
Q
G
G
G
----
H
A
E
K
G
H
R
C
P
G
E
G
I
T
I
E
V
M
K
A
S
L
D
F
L
V
H
Q
I
E
Y
D
V
P
E
Q
S
L
H
Y
S
L
A
R
M
P
S
L
P
E
S
G
F
V
M
S
G
I
R
R
K
-
8
PsiBlast_PDB
76.86
44%
-110
- C4 -
3VM4
4
?
A:
[3-403]
-----------
D
E
T
L
S
L
L
A
D
P
Y
R
F
I
S
R
Q
C
Q
R
L
G
A
N
-
A
F
E
S
R
-
F
L
L
-
K
K
T
N
C
L
K
G
A
K
A
A
E
I
F
Y
D
T
T
R
F
E
R
E
G
A
M
P
V
A
I
Q
K
T
L
L
G
Q
G
G
V
Q
G
L
D
G
E
T
H
R
H
R
K
Q
M
F
M
G
L
M
T
P
E
R
V
R
A
L
A
Q
L
F
E
A
E
W
R
R
A
V
P
G
W
T
R
K
G
E
I
V
F
Y
D
E
L
H
E
P
L
T
R
A
V
C
A
W
A
-
G
V
P
L
P
D
D
E
A
G
N
R
A
G
E
L
R
A
L
F
D
A
A
G
S
---
A
S
P
R
H
L
W
S
----
R
L
A
R
R
R
V
D
A
W
A
K
R
I
I
E
G
I
R
A
G
S
I
G
S
G
S
G
T
A
A
Y
A
I
A
W
H
R
D
R
-
H
D
D
L
L
S
P
H
V
A
A
V
E
L
V
N
V
L
R
P
T
V
A
I
A
V
Y
I
T
F
V
A
H
A
L
Q
T
C
S
G
I
R
A
A
L
V
Q
-
Q
P
-
D
Y
A
E
L
F
V
Q
E
V
R
R
F
Y
P
F
F
P
A
V
V
A
R
A
S
Q
D
F
E
W
E
G
M
A
F
P
E
G
R
Q
V
V
L
D
L
Y
G
S
N
H
D
A
A
T
W
A
D
P
Q
E
F
R
P
E
R
F
R
A
W
D
E
D
S
F
N
F
I
P
Q
G
G
G
----
D
H
Y
L
G
H
R
C
P
G
E
W
I
V
L
A
I
M
K
V
A
A
H
L
L
V
N
A
M
R
Y
D
V
P
D
Q
D
L
S
I
D
F
A
R
L
P
A
L
P
K
S
G
F
V
M
R
N
V
----
6
PsiBlast_PDB
76.76
44%
-108
- C4 -
3AWM
3
?
A:
[9-411]
---------
G
P
D
E
T
L
S
L
L
A
D
P
Y
R
F
I
S
R
Q
C
Q
R
L
G
A
N
-
A
F
E
S
R
-
F
L
L
-
K
K
T
N
C
L
K
G
A
K
A
A
E
I
F
Y
D
T
T
R
F
E
R
E
G
A
M
P
V
A
I
Q
K
T
L
L
G
Q
G
G
V
Q
G
L
D
G
E
T
H
R
H
R
K
Q
M
F
M
G
L
M
T
P
E
R
V
R
A
L
A
Q
L
F
E
A
E
W
R
R
A
V
P
G
W
T
R
K
G
E
I
V
F
Y
D
E
L
H
E
P
L
T
R
A
V
C
A
W
A
-
G
V
P
L
P
D
D
E
A
G
N
R
A
G
E
L
R
A
L
F
D
A
A
G
S
---
A
S
P
R
H
L
W
S
----
R
L
A
R
R
R
V
D
A
W
A
K
R
I
I
E
G
I
R
A
G
S
I
G
S
G
S
G
T
A
A
Y
A
I
A
W
H
R
D
R
-
H
D
D
L
L
S
P
H
V
A
A
V
E
L
V
N
V
L
R
P
T
V
A
I
A
V
Y
I
T
F
V
A
H
A
L
Q
T
C
S
G
I
R
A
A
L
V
Q
-
Q
P
-
D
Y
A
E
L
F
V
Q
E
V
R
R
F
Y
P
F
F
P
A
V
V
A
R
A
S
Q
D
F
E
W
E
G
M
A
F
P
E
G
R
Q
V
V
L
D
L
Y
G
S
N
H
D
A
A
T
W
A
D
P
Q
E
F
R
P
E
R
F
R
A
W
D
E
D
S
F
N
F
I
P
Q
G
G
G
----
D
H
Y
L
G
H
R
C
P
G
E
W
I
V
L
A
I
M
K
V
A
A
H
L
L
V
N
A
M
R
Y
D
V
P
D
Q
D
L
S
I
D
F
A
R
L
P
A
L
P
K
S
G
F
V
M
R
N
V
----
5
PsiBlast_PDB
76.20
44%
-107
- C4 -
3AWQ
2
?
A:
[9-411]
---------
G
P
D
E
T
L
S
L
L
A
D
P
Y
R
F
I
S
R
Q
C
Q
R
L
G
A
N
-
A
F
E
S
R
-
F
L
L
-
K
K
T
N
C
L
K
G
A
K
A
A
E
I
F
Y
D
T
T
R
F
E
R
E
G
A
M
P
V
A
I
Q
K
T
L
F
G
Q
G
G
V
Q
G
L
D
G
E
T
H
R
H
R
K
Q
M
F
M
G
L
M
T
P
E
R
V
R
A
L
A
Q
L
F
E
A
E
W
R
R
A
V
P
G
W
T
R
K
G
E
I
V
F
Y
D
E
L
H
E
P
L
T
R
A
V
C
A
W
A
-
G
V
P
L
P
D
D
E
A
G
N
R
A
G
E
L
R
A
L
F
D
A
A
G
S
---
A
S
P
R
H
L
W
S
----
R
L
A
R
R
R
V
D
A
W
A
K
R
I
I
E
G
I
R
A
G
S
I
G
S
G
S
G
T
A
A
Y
A
I
A
W
H
R
D
R
-
H
D
D
L
L
S
P
H
V
A
A
V
E
L
V
N
V
L
R
P
T
V
A
I
A
V
Y
I
T
F
V
A
H
A
L
Q
T
C
S
G
I
R
A
A
L
V
Q
-
Q
P
-
D
Y
A
E
L
F
V
Q
E
V
R
R
F
Y
P
F
F
P
A
V
V
A
R
A
S
Q
D
F
E
W
E
G
M
A
F
P
E
G
R
Q
V
V
L
D
L
Y
G
S
N
H
D
A
A
T
W
A
D
P
Q
E
F
R
P
E
R
F
R
A
W
D
E
D
S
F
N
F
I
P
Q
G
G
G
----
D
H
Y
L
G
H
R
C
P
G
E
W
I
V
L
A
I
M
K
V
A
A
H
L
L
V
N
A
M
R
Y
D
V
P
D
Q
D
L
S
I
D
F
A
R
L
P
A
L
P
K
S
G
F
V
M
R
N
V
----
9
PsiBlast_PDB
76.17
44%
-109
- C4 -
3VOO
1
?
A:
[3-403]
-----------
D
E
T
L
S
L
L
A
D
P
Y
R
F
I
S
R
Q
C
Q
R
L
G
A
N
-
A
F
E
S
R
-
F
L
L
-
K
K
T
N
C
L
K
G
A
K
A
A
E
I
F
Y
D
T
T
R
F
E
R
E
G
A
M
P
V
A
I
Q
K
T
L
L
G
Q
G
G
V
Q
G
L
D
G
E
T
H
R
H
R
K
Q
M
F
M
G
L
M
T
P
E
R
V
R
A
L
A
Q
L
F
E
A
E
W
R
R
A
V
P
G
W
T
R
K
G
E
I
V
F
Y
D
E
L
H
E
P
L
T
R
A
V
C
A
W
A
-
G
V
P
L
P
D
D
E
A
G
N
R
A
G
E
L
R
A
L
F
D
A
A
G
S
---
A
S
P
R
H
L
W
S
----
R
L
A
R
R
R
V
D
A
W
A
K
R
I
I
E
G
I
R
A
G
S
I
G
S
G
S
G
T
A
A
Y
A
I
A
W
H
R
D
R
-
H
D
D
L
L
S
P
H
V
A
A
V
E
L
V
N
V
L
R
P
T
V
E
I
A
V
Y
I
T
F
V
A
H
A
L
Q
T
C
S
G
I
R
A
A
L
V
Q
-
Q
P
-
D
Y
A
E
L
F
V
Q
E
V
R
R
F
Y
P
F
F
P
A
V
V
A
R
A
S
Q
D
F
E
W
E
G
M
A
F
P
E
G
R
Q
V
V
L
D
L
Y
G
S
N
H
D
A
A
T
W
A
D
P
Q
E
F
R
P
E
R
F
R
A
W
D
E
D
S
F
N
F
I
P
Q
G
G
G
----
D
H
Y
L
G
H
R
C
P
G
E
W
I
V
L
A
I
M
K
V
A
A
H
L
L
V
N
A
M
R
Y
D
V
P
D
Q
D
L
S
I
D
F
A
R
L
P
A
L
P
K
S
G
F
V
M
R
N
V
----
7
PsiBlast_PDB
75.98
44%
-106
- C4 -
3VTJ
1
?
A:
[9-411]
---------
G
P
D
E
T
L
S
L
L
A
D
P
Y
R
F
I
S
R
Q
C
Q
R
L
G
A
N
-
A
F
E
S
R
-
F
L
L
-
K
K
T
N
C
L
K
G
A
K
A
A
E
I
F
Y
D
T
T
R
F
E
R
E
G
A
M
P
V
A
I
Q
K
T
L
L
G
Q
G
G
V
Q
G
L
D
G
E
T
H
R
H
R
K
Q
M
F
M
G
L
M
T
P
E
R
V
R
A
L
A
Q
L
F
E
A
E
W
R
R
A
V
P
G
W
T
R
K
G
E
I
V
F
Y
D
E
L
H
E
P
L
T
R
A
V
C
A
W
A
-
G
V
P
L
P
D
D
E
A
G
N
R
A
G
E
L
R
A
L
F
D
A
A
G
S
---
A
S
P
R
H
L
W
S
----
R
L
A
R
R
R
V
D
A
W
A
K
R
I
I
E
G
I
R
A
G
S
I
G
S
G
S
G
T
A
A
Y
A
I
A
W
H
R
D
R
-
H
D
D
L
L
S
P
H
V
A
A
V
E
L
V
N
V
L
R
P
T
V
H
I
A
V
Y
I
T
F
V
A
H
A
L
Q
T
C
S
G
I
R
A
A
L
V
Q
-
Q
P
-
D
Y
A
E
L
F
V
Q
E
V
R
R
F
Y
P
F
F
P
A
V
V
A
R
A
S
Q
D
F
E
W
E
G
M
A
F
P
E
G
R
Q
V
V
L
D
L
Y
G
S
N
H
D
A
A
T
W
A
D
P
Q
E
F
R
P
E
R
F
R
A
W
D
E
D
S
F
N
F
I
P
Q
G
G
G
----
D
H
Y
L
G
H
R
C
P
G
E
W
I
V
L
A
I
M
K
V
A
A
H
L
L
V
N
A
M
R
Y
D
V
P
D
Q
D
L
S
I
D
F
A
R
L
P
A
L
P
K
S
G
F
V
M
R
N
V
----
4
PsiBlast_PDB
75.91
44%
-105
- C4 -
3AWP
4
?
A:
[9-411]
---------
G
P
D
E
T
L
S
L
L
A
D
P
Y
R
F
I
S
R
Q
C
Q
R
L
G
A
N
-
A
F
E
S
R
-
F
L
L
-
K
K
T
N
C
L
K
G
A
K
A
A
E
I
F
Y
D
T
T
R
F
E
R
E
G
A
M
P
V
A
I
Q
K
T
L
L
G
Q
G
G
V
Q
G
L
D
G
E
T
H
R
H
R
K
Q
M
F
M
G
L
M
T
P
E
R
V
R
A
L
A
Q
L
F
E
A
E
W
R
R
A
V
P
G
W
T
R
K
G
E
I
V
F
Y
D
E
L
H
E
P
L
T
R
A
V
C
A
W
A
-
G
V
P
L
P
D
D
E
A
G
N
R
A
G
E
L
R
A
L
F
D
A
A
G
S
---
A
S
P
R
H
L
W
S
----
R
L
A
R
R
R
V
D
A
W
A
K
R
I
I
E
G
I
R
A
G
S
I
G
S
G
S
G
T
A
A
Y
A
I
A
W
H
R
D
R
-
H
D
D
L
L
S
P
H
V
A
A
V
E
L
V
N
V
L
R
P
T
V
A
I
A
V
Y
I
T
F
V
A
H
A
L
Q
T
C
S
G
I
R
A
A
L
V
Q
-
Q
P
-
D
Y
A
E
L
F
V
Q
E
V
R
R
F
Y
P
F
G
P
A
V
V
A
R
A
S
Q
D
F
E
W
E
G
M
A
F
P
E
G
R
Q
V
V
L
D
L
Y
G
S
N
H
D
A
A
T
W
A
D
P
Q
E
F
R
P
E
R
F
R
A
W
D
E
D
S
F
N
F
I
P
Q
G
G
G
----
D
H
Y
L
G
H
R
C
P
G
E
W
I
V
L
A
I
M
K
V
A
A
H
L
L
V
N
A
M
R
Y
D
V
P
D
Q
D
L
S
I
D
F
A
R
L
P
A
L
P
K
S
G
F
V
M
R
N
V
----
10
PsiBlast_PDB
75.90
44%
-107
- C4 -
3VNO
2
?
A:
[3-403]
-----------
D
E
T
L
S
L
L
A
D
P
Y
R
F
I
S
R
Q
C
Q
R
L
G
A
N
-
A
F
E
S
R
-
F
L
L
-
K
K
T
N
C
L
K
G
A
K
A
A
E
I
F
Y
D
T
T
R
F
E
R
E
G
A
M
P
V
A
I
Q
K
T
L
L
G
Q
G
G
V
Q
G
L
D
G
E
T
H
R
H
R
K
Q
M
F
M
G
L
M
T
P
E
R
V
R
A
L
A
Q
L
F
E
A
E
W
R
R
A
V
P
G
W
T
R
K
G
E
I
V
F
Y
D
E
L
H
E
P
L
T
R
A
V
C
A
W
A
-
G
V
P
L
P
D
D
E
A
G
N
R
A
G
E
L
R
A
L
F
D
A
A
G
S
---
A
S
P
R
H
L
W
S
----
R
L
A
R
R
R
V
D
A
W
A
K
R
I
I
E
G
I
R
A
G
S
I
G
S
G
S
G
T
A
A
Y
A
I
A
W
H
R
D
R
-
H
D
D
L
L
S
P
H
V
A
A
V
E
L
V
N
V
L
E
P
T
V
A
I
A
V
Y
I
T
F
V
A
H
A
L
Q
T
C
S
G
I
R
A
A
L
V
Q
-
Q
P
-
D
Y
A
E
L
F
V
Q
E
V
R
R
F
Y
P
F
F
P
A
V
V
A
R
A
S
Q
D
F
E
W
E
G
M
A
F
P
E
G
R
Q
V
V
L
D
L
Y
G
S
N
H
D
A
A
T
W
A
D
P
Q
E
F
R
P
E
R
F
R
A
W
D
E
D
S
F
N
F
I
P
Q
G
G
G
----
D
H
Y
L
G
H
R
C
P
G
E
W
I
V
L
A
I
M
K
V
A
A
H
L
L
V
N
A
M
R
Y
D
V
P
D
Q
D
L
S
I
D
F
A
R
L
P
A
L
P
K
S
G
F
V
M
R
N
V
----
12
PsiBlast_PDB
72.25
41%
-96
- C4 -
4L54
1
?
A:
[4-416]
----
L
K
R
D
K
G
L
D
N
T
L
K
V
L
K
Q
G
Y
L
Y
T
T
N
Q
R
N
R
L
N
T
S
-
V
F
Q
T
K
-
A
L
G
G
K
P
F
V
V
V
T
G
K
E
G
A
E
M
F
Y
N
N
D
V
V
Q
R
E
G
M
L
P
K
R
I
V
N
T
L
F
G
K
G
A
I
H
T
V
D
G
K
K
H
V
D
R
K
A
L
F
M
S
L
M
T
E
G
N
L
N
Y
V
R
E
L
T
R
T
L
W
H
A
N
T
Q
R
M
E
S
M
D
E
V
N
I
Y
R
E
S
I
V
L
L
T
K
V
G
T
R
W
A
-
G
V
Q
A
P
P
E
D
I
E
R
I
A
T
D
M
D
I
M
I
D
S
F
R
A
---
L
G
G
-
A
F
K
G
Y
K
A
S
K
E
A
R
R
R
V
E
D
W
L
E
E
Q
I
I
E
T
R
K
G
N
I
H
P
P
E
G
T
A
L
Y
E
F
A
H
W
E
D
Y
-
L
G
N
P
M
D
S
R
T
C
A
I
D
L
M
N
T
F
R
P
L
I
A
I
N
R
F
V
S
F
G
L
H
A
M
N
E
N
P
I
T
R
E
K
I
K
S
E
P
D
-
Y
A
Y
K
-
F
A
Q
E
V
R
R
Y
Y
P
F
V
P
F
L
P
G
K
A
K
V
D
I
D
F
Q
G
V
T
I
P
A
G
V
G
L
A
L
D
V
Y
G
T
T
H
D
E
S
L
W
D
D
P
N
E
F
R
P
E
R
F
E
T
W
D
G
S
P
F
D
L
I
P
Q
G
G
G
----
D
Y
W
T
N
H
R
C
A
G
E
W
I
T
V
I
I
M
E
E
T
M
K
Y
F
A
E
K
I
T
Y
D
V
P
E
Q
D
L
E
V
D
L
N
S
I
P
G
Y
V
K
S
G
F
V
I
K
N
V
R
---
11
PsiBlast_PDB
72.03
41%
-96
- C4 -
4L40
2
?
A:
[4-416]
----
L
K
R
D
K
G
L
D
N
T
L
K
V
L
K
Q
G
Y
L
Y
T
T
N
Q
R
N
R
L
N
T
S
-
V
F
Q
T
K
-
A
L
G
G
K
P
F
V
V
V
T
G
K
E
G
A
E
M
F
Y
N
N
D
V
V
Q
R
E
G
M
L
P
K
R
I
V
N
T
L
F
G
K
G
A
I
H
T
V
D
G
K
K
H
V
D
R
K
A
L
F
M
S
L
M
T
E
G
N
L
N
Y
V
R
E
L
T
R
T
L
W
H
A
N
T
Q
R
M
E
S
M
D
E
V
N
I
Y
R
E
S
I
V
L
L
T
K
V
G
T
R
W
A
-
G
V
Q
A
P
P
E
D
I
E
R
I
A
T
D
M
D
I
M
I
D
S
F
R
A
---
L
G
G
-
A
F
K
G
Y
K
A
S
K
E
A
R
R
R
V
E
D
W
L
E
E
Q
I
I
E
T
R
K
G
N
I
H
P
P
E
G
T
A
L
Y
E
F
A
H
W
E
D
Y
-
L
G
N
P
M
D
S
R
T
C
A
I
D
L
M
N
T
F
R
P
L
I
A
I
N
R
F
V
S
F
G
L
H
A
M
N
E
N
P
I
T
R
E
K
I
K
S
E
P
D
-
Y
A
Y
K
-
F
A
Q
E
V
R
R
Y
Y
P
F
V
P
F
L
P
G
K
A
K
V
D
I
D
F
Q
G
V
T
I
P
A
G
V
G
L
A
L
D
V
Y
G
T
T
H
D
E
S
L
W
D
D
P
N
E
F
R
P
E
R
F
E
T
W
D
G
S
P
F
D
L
I
P
Q
G
G
G
----
D
Y
W
T
N
H
R
C
A
G
E
W
I
T
V
I
I
M
E
E
T
M
K
Y
F
A
E
K
I
T
Y
D
V
P
E
Q
D
L
E
V
D
L
N
S
I
P
G
Y
V
K
S
G
F
V
I
K
N
V
R
---
101
HHSearch
71.82
43%
-108
- C4 -
3AWM
3
?
A:
[9-414]
---------
G
P
D
E
T
L
S
L
L
A
D
P
Y
R
F
I
S
R
Q
C
Q
R
L
G
-
A
N
A
F
E
S
R
-
F
L
L
-
K
K
T
N
C
L
K
G
A
K
A
A
E
I
F
Y
D
T
T
R
F
E
R
E
G
A
M
P
V
A
I
Q
K
T
L
L
G
Q
G
G
V
Q
G
L
D
G
E
T
H
R
H
R
K
Q
M
F
M
G
L
M
T
P
E
R
V
R
A
L
A
Q
L
F
E
A
E
W
R
R
A
V
P
G
W
T
R
K
G
E
I
V
F
Y
D
E
L
H
E
P
L
T
R
A
V
C
A
-
W
A
G
V
P
L
P
D
D
E
A
G
N
R
A
G
E
L
R
A
L
F
D
A
A
G
S
---
A
S
P
R
H
L
W
S
----
R
L
A
R
R
R
V
D
A
W
A
K
R
I
I
E
G
I
R
A
G
S
I
-
G
S
G
S
G
T
A
A
Y
A
I
A
W
H
R
D
R
H
D
D
L
L
S
P
H
V
A
A
V
E
L
V
N
V
L
R
P
T
V
A
I
A
V
Y
I
T
F
V
A
H
A
L
Q
T
C
S
G
I
R
A
A
L
V
Q
Q
-
P
-
D
Y
A
E
L
F
V
Q
E
V
R
R
F
Y
P
F
F
P
A
V
V
A
R
A
S
Q
D
F
E
W
E
G
M
A
F
P
E
G
R
Q
V
V
L
D
L
Y
G
S
N
H
D
A
A
T
W
A
D
P
Q
E
F
R
P
E
R
F
R
A
W
D
E
D
S
F
N
F
I
P
Q
G
G
G
----
D
H
Y
L
G
H
R
C
P
G
E
W
I
V
L
A
I
M
K
V
A
A
H
L
L
V
N
A
M
R
Y
D
V
P
D
Q
D
L
S
I
D
F
A
R
L
P
A
L
P
K
S
G
F
V
M
R
N
V
H
I
G
-
100
HHSearch
69.67
41%
-92
- C4 -
4L54
1
?
A:
[4-418]
----
L
K
R
D
K
G
L
D
N
T
L
K
V
L
K
Q
G
Y
L
Y
T
T
N
Q
R
N
R
L
N
T
S
-
V
F
Q
T
K
A
L
G
G
-
K
P
F
V
V
V
T
G
K
E
G
A
E
M
F
Y
N
N
D
V
V
Q
R
E
G
M
L
P
K
R
I
V
N
T
L
F
G
K
G
A
I
H
T
V
D
G
K
K
H
V
D
R
K
A
L
F
M
S
L
M
T
E
G
N
L
N
Y
V
R
E
L
T
R
T
L
W
H
A
N
T
Q
R
M
E
S
M
D
E
V
N
I
Y
R
E
S
I
V
L
L
T
K
V
G
T
R
-
W
A
G
V
Q
A
P
P
E
D
I
E
R
I
A
T
D
M
D
I
M
I
D
S
F
R
A
LGG
A
F
K
G
Y
K
A
S
----
K
E
A
R
R
R
V
E
D
W
L
E
E
Q
I
I
E
T
R
K
G
N
I
H
P
P
E
G
T
A
L
Y
E
F
A
H
W
E
D
Y
-
L
G
N
P
M
D
S
R
T
C
A
I
D
L
M
N
T
F
R
P
L
I
A
I
N
R
F
V
S
F
G
L
H
A
M
N
E
N
P
I
T
R
E
K
I
K
S
E
-
P
-
D
Y
A
Y
K
F
A
Q
E
V
R
R
Y
Y
P
F
V
P
F
L
P
G
K
A
K
V
D
I
D
F
Q
G
V
T
I
P
A
G
V
G
L
A
L
D
V
Y
G
T
T
H
D
E
S
L
W
D
D
P
N
E
F
R
P
E
R
F
E
T
W
D
G
S
P
F
D
L
I
P
Q
G
G
G
DYWT
N
----
H
R
C
A
G
E
W
I
T
V
I
I
M
E
E
T
M
K
Y
F
A
E
K
I
T
Y
D
V
P
E
Q
D
L
E
V
D
L
N
S
I
P
G
Y
V
K
S
G
F
V
I
K
N
V
R
E
V
-