@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu02490: (2016-06-04 )
MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSPFFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFGDQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGYLFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKGGVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDENGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVRVAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPFEISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKRPCLVR
Atome Classification :
(30 SA)
.........10........20........30..-......40........50-........60......-..-70........80........90........100..---.....110.------......120---.----......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.....-.-.-330.......340.......350.......360.......370.......380--.--..-....-.390........400.......410.......420.......430.......440.......450...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSS
P
I
Q
E
Q
V
Q
K
E
K
RSNIPSIS
E
M
K
V
I
P
VAGH
D
S
-
M
L
L
N
LSGAHSP
F
F
T
R
N
I
V
-
I
L
TDSSGNQGVGEVP
G
-
G
E
-
H
I
R
R
T
LELSE
P
L
V
VGKSI
G
A
Y
Q
A
I
L
Q
T
V
R
K
QFGDQ---DRGGRGN
Q
T
------
F
D
L
R
T
T
V
H
A
---
V
----
T
A
L
E
A
A
L
L
D
L
L
G
K
F
L
Q
E
P
V
A
A
L
L
GEGKQ
R
D
E
V
K
M
L
G
Y
L
F
Y
IGDRNRTTLPYQSDEQSD
C
A
W
F
R
L
RHEEAL
T
P
E
A
I
V
R
L
A
E
S
A
Q
E
RYGFQD
F
K
LKGGVLR
G
E
E
E
I
E
A
V
T
A
L
S
K
RFPE
A
R
I
T
LDPNGAW
S
L
E
E
A
I
A
L
CKGK
Q
D
V
L
A
YAEDPCGDENGY
S
A
R
E
V
M
A
E
F
R
R
ATGLPT
A
T
N
M
I
A
T
D
W
R
EMG
H
A
I
Q
L
H
A
VDIPLADP
H
F
W
-
T
-M-QG
S
V
R
V
A
Q
M
C
H
D
WGLTWGSHSN
N
H
F
D
I
S
L
A
M
F
T
H
V
A
AAAPG
R
I
T
A
I
D
T
H
W
I
W---Q--DG-
Q
R
LT-KQ-PFEISSG
C
V
KVPDKPGLGVDI
D
M
E
Q
V
E
K
A
H
E
I
Y
R
K
MNLGARNDAI
P
M
Q
F
L
I
SNWEFDRKRPCLVR
2
PsiBlast_PDB
86.10
72%
-87
- C1 -
1EC7
3
GUDD_ECOLI
A:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
----------------------
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
21
PsiBlast_CBE
85.80
74%
-80
- C1 -
4G8T
4
?
D:
[24-464]
---------------
S
T
P
I
I
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
L
N
L
S
G
A
H
S
P
Y
F
T
R
N
I
V
-
I
L
K
D
N
S
G
N
T
G
V
G
E
V
P
G
-
G
E
-
K
I
R
Q
T
L
E
D
A
K
P
L
V
I
G
K
T
L
G
E
Y
K
N
V
M
N
T
V
R
Q
T
F
N
D
H
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
A
I
E
A
A
M
L
D
L
L
G
Q
F
L
G
V
T
V
A
S
L
L
G
D
G
Q
Q
R
D
A
V
E
M
L
G
Y
L
F
F
I
G
D
R
K
K
T
T
L
A
Y
Q
N
Q
E
N
D
P
C
D
W
Y
R
V
R
H
E
E
A
M
T
P
E
S
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
D
G
F
E
E
A
E
A
V
T
A
L
A
K
R
F
P
D
A
R
I
T
L
D
P
N
G
A
W
S
L
D
E
A
V
K
I
G
K
Q
L
K
G
V
L
A
Y
A
E
D
P
C
G
A
E
Q
G
Y
S
G
R
E
I
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
I
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
I
R
V
A
Q
M
C
H
E
W
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
D
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
Q
I
K
G
G
L
V
E
V
P
K
K
P
G
L
G
V
E
L
D
M
D
Q
V
M
K
A
N
E
L
Y
K
S
M
G
L
G
A
R
D
D
A
M
A
M
Q
F
L
I
P
G
W
K
F
D
N
K
K
P
C
L
V
R
1
PsiBlast_PDB
85.41
74%
-78
- C1 -
4G8T
7
?
A:
[24-464]
---------------
S
T
P
I
I
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
L
N
L
S
G
A
H
S
P
Y
F
T
R
N
I
V
-
I
L
K
D
N
S
G
N
T
G
V
G
E
V
P
G
-
G
E
-
K
I
R
Q
T
L
E
D
A
K
P
L
V
I
G
K
T
L
G
E
Y
K
N
V
M
N
T
V
R
Q
T
F
N
D
H
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
A
I
E
A
A
M
L
D
L
L
G
Q
F
L
G
V
T
V
A
S
L
L
G
D
G
Q
Q
R
D
A
V
E
M
L
G
Y
L
F
F
I
G
D
R
K
K
T
T
L
A
Y
Q
N
Q
E
N
D
P
C
D
W
Y
R
V
R
H
E
E
A
M
T
P
E
S
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
D
G
F
E
E
A
E
A
V
T
A
L
A
K
R
F
P
D
A
R
I
T
L
D
P
N
G
A
W
S
L
D
E
A
V
K
I
G
K
Q
L
K
G
V
L
A
Y
A
E
D
P
C
G
A
E
Q
G
Y
S
G
R
E
I
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
I
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
I
R
V
A
Q
M
C
H
E
W
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
D
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
Q
I
K
G
G
L
V
E
V
P
K
K
P
G
L
G
V
E
L
D
M
D
Q
V
M
K
A
N
E
L
Y
K
S
M
G
L
G
A
R
D
D
A
M
A
M
Q
F
L
I
P
G
W
K
F
D
N
K
K
P
C
L
V
R
5
PsiBlast_PDB
84.80
72%
-79
- C1 -
1ECQ
4
GUDD_ECOLI
A:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
22
PsiBlast_CBE
84.53
74%
-78
- C1 -
4G8T
5
?
C:
[24-464]
---------------
S
T
P
I
I
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
L
N
L
S
G
A
H
S
P
Y
F
T
R
N
I
V
-
I
L
K
D
N
S
G
N
T
G
V
G
E
V
P
G
-
G
E
-
K
I
R
Q
T
L
E
D
A
K
P
L
V
I
G
K
T
L
G
E
Y
K
N
V
M
N
T
V
R
Q
T
F
N
D
H
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
A
I
E
A
A
M
L
D
L
L
G
Q
F
L
G
V
T
V
A
S
L
L
G
D
G
Q
Q
R
D
A
V
E
M
L
G
Y
L
F
F
I
G
D
R
K
K
T
T
L
A
Y
Q
N
Q
E
N
D
P
C
D
W
Y
R
V
R
H
E
E
A
M
T
P
E
S
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
D
G
F
E
E
A
E
A
V
T
A
L
A
K
R
F
P
D
A
R
I
T
L
D
P
N
G
A
W
S
L
D
E
A
V
K
I
G
K
Q
L
K
G
V
L
A
Y
A
E
D
P
C
G
A
E
Q
G
Y
S
G
R
E
I
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
I
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
I
R
V
A
Q
M
C
H
E
W
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
D
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
Q
I
K
G
G
L
V
E
V
P
K
K
P
G
L
G
V
E
L
D
M
D
Q
V
M
K
A
N
E
L
Y
K
S
M
G
L
G
A
R
D
D
A
M
A
M
Q
F
L
I
P
G
W
K
F
D
N
K
K
P
C
L
V
R
44
PsiBlast_CBE
84.44
72%
-79
- C1 -
3PWG
5
GUDD_ECOLI
B:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
G
G
A
H
A
A
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
23
PsiBlast_CBE
84.29
74%
-76
- C1 -
4G8T
8
?
B:
[24-464]
---------------
S
T
P
I
I
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
L
N
L
S
G
A
H
S
P
Y
F
T
R
N
I
V
-
I
L
K
D
N
S
G
N
T
G
V
G
E
V
P
G
-
G
E
-
K
I
R
Q
T
L
E
D
A
K
P
L
V
I
G
K
T
L
G
E
Y
K
N
V
M
N
T
V
R
Q
T
F
N
D
H
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
A
I
E
A
A
M
L
D
L
L
G
Q
F
L
G
V
T
V
A
S
L
L
G
D
G
Q
Q
R
D
A
V
E
M
L
G
Y
L
F
F
I
G
D
R
K
K
T
T
L
A
Y
Q
N
Q
E
N
D
P
C
D
W
Y
R
V
R
H
E
E
A
M
T
P
E
S
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
D
G
F
E
E
A
E
A
V
T
A
L
A
K
R
F
P
D
A
R
I
T
L
D
P
N
G
A
W
S
L
D
E
A
V
K
I
G
K
Q
L
K
G
V
L
A
Y
A
E
D
P
C
G
A
E
Q
G
Y
S
G
R
E
I
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
I
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
I
R
V
A
Q
M
C
H
E
W
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
D
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
Q
I
K
G
G
L
V
E
V
P
K
K
P
G
L
G
V
E
L
D
M
D
Q
V
M
K
A
N
E
L
Y
K
S
M
G
L
G
A
R
D
D
A
M
A
M
Q
F
L
I
P
G
W
K
F
D
N
K
K
P
C
L
V
R
35
PsiBlast_CBE
84.25
72%
-85
- C1 -
1EC7
3
GUDD_ECOLI
C:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
-----------------------
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
7
PsiBlast_PDB
84.03
72%
-78
- C1 -
1JDF
5
GUDD_ECOLI
A:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
D
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
42
PsiBlast_CBE
83.75
72%
-90
- C1 -
3PWG
4
GUDD_ECOLI
D:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
G
G
A
H
A
A
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
------------------------
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
39
PsiBlast_CBE
83.69
72%
-78
- C1 -
1JDF
5
GUDD_ECOLI
B:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
D
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
36
PsiBlast_CBE
83.69
72%
-77
- C1 -
1EC7
3
GUDD_ECOLI
B:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
--
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
27
PsiBlast_CBE
83.46
72%
-78
- C1 -
1ECQ
4
GUDD_ECOLI
B:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
6
PsiBlast_PDB
83.42
72%
-76
- C1 -
4GYP
5
GUDD_ECOLI
A:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
33
PsiBlast_CBE
83.27
72%
-75
- C1 -
1EC8
4
GUDD_ECOLI
B:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
34
PsiBlast_CBE
83.24
72%
-82
- C1 -
1EC7
3
GUDD_ECOLI
D:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---------------------
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
28
PsiBlast_CBE
83.18
72%
-75
- C1 -
1EC9
4
GUDD_ECOLI
D:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
4
PsiBlast_PDB
83.16
72%
-75
- C1 -
1EC9
4
GUDD_ECOLI
A:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
24
PsiBlast_CBE
83.06
72%
-77
- C1 -
4GYP
5
GUDD_ECOLI
B:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
3
PsiBlast_PDB
82.99
72%
-77
- C1 -
1EC8
4
GUDD_ECOLI
A:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
9
PsiBlast_PDB
82.54
72%
-78
- C1 -
1JCT
3
GUDD_ECOLI
A:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
L
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
8
PsiBlast_PDB
82.45
72%
-77
- C1 -
3PWI
3
GUDD_ECOLI
A:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
A
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
40
PsiBlast_CBE
81.76
72%
-77
- C1 -
3PWI
3
GUDD_ECOLI
B:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
A
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
N
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
41
PsiBlast_CBE
81.24
72%
-79
- C1 -
1JCT
3
GUDD_ECOLI
B:
[8-446]
-----------------
P
V
V
T
E
M
Q
V
I
P
V
A
G
H
D
S
-
M
L
M
N
L
S
G
A
H
A
P
F
F
T
R
N
I
V
-
I
I
K
D
N
S
G
H
T
G
V
G
E
I
P
G
-
G
E
-
K
I
R
K
T
L
E
D
A
I
P
L
V
V
G
K
T
L
G
E
Y
K
N
V
L
T
L
V
R
N
T
F
A
D
R
---
D
A
G
G
R
G
L
Q
T
------
F
D
L
R
T
T
I
H
V
---
V
----
T
G
I
E
A
A
M
L
D
L
L
G
Q
H
L
G
V
N
V
A
S
L
L
G
D
G
Q
Q
R
S
E
V
E
M
L
G
Y
L
F
F
V
G
N
R
K
A
T
P
L
P
Y
Q
S
Q
P
D
D
S
C
D
W
Y
R
L
R
H
E
E
A
M
T
P
D
A
V
V
R
L
A
E
A
A
Y
E
K
Y
G
F
N
D
F
K
L
K
G
G
V
L
A
G
E
E
E
A
E
S
I
V
A
L
A
Q
R
F
P
Q
A
R
I
T
L
D
P
N
G
A
W
S
L
N
E
A
I
K
I
G
K
Y
L
K
G
S
L
A
Y
A
E
D
P
C
G
A
E
Q
G
F
S
G
R
E
V
M
A
E
F
R
R
A
T
G
L
P
T
A
T
N
M
I
A
T
D
W
R
Q
M
G
H
T
L
S
L
Q
S
V
D
I
P
L
A
D
P
H
F
W
-
T
-
M
-
Q
G
S
V
R
V
A
Q
M
C
H
E
F
G
L
T
W
G
S
H
S
L
N
H
F
D
I
S
L
A
M
F
T
H
V
A
A
A
A
P
G
K
I
T
A
I
D
T
H
W
I
W
---
Q
--
E
G
N
Q
R
L
T
-
K
E
-
P
F
E
I
K
G
G
L
V
Q
V
P
E
K
P
G
L
G
V
E
I
D
M
D
Q
V
M
K
A
H
E
L
Y
Q
K
H
G
L
G
A
R
D
D
A
M
G
M
Q
Y
L
I
P
G
W
T
F
D
N
K
R
P
C
M
V
R
68
PsiBlast_CBE
64.47
34%
-92
- C1 -
3VC6
3
?
A:
[25-423]
-------------------
I
R
E
V
R
V
T
P
V
A
F
R
D
P
-
P
L
L
N
A
A
G
V
H
Q
P
W
A
L
R
T
I
V
-
E
V
V
T
D
E
G
I
T
G
L
G
E
T
Y
G
-
D
L
-
A
H
L
E
Q
V
R
A
A
A
A
R
L
P
G
L
D
V
Y
A
L
H
R
I
Y
R
R
V
A
D
V
V
G
A
N
I
V
T
D
M
H
G
L
T
G
S
S
------
S
R
V
K
T
V
D
R
V
---
F
----
A
A
F
E
V
A
C
L
D
I
Q
G
K
A
A
G
R
P
V
A
D
L
L
G
-
G
K
V
R
D
A
V
P
Y
S
A
Y
L
F
Y
----
K
W
A
G
H
P
G
K
P
E
D
---------
R
F
G
P
A
L
D
P
D
G
I
V
A
Q
A
R
L
L
I
G
E
Y
G
F
R
S
I
K
L
K
G
G
V
F
P
P
E
Q
E
A
E
A
I
Q
A
L
R
D
A
F
P
G
L
P
L
R
L
D
P
N
A
A
W
T
V
E
T
S
I
R
V
G
R
A
L
D
G
V
L
E
Y
L
E
D
P
T
P
G
I
D
G
------
M
A
R
V
A
A
E
V
P
M
P
L
A
T
N
M
C
V
V
T
P
E
H
L
P
A
A
V
E
R
R
P
I
G
V
L
L
I
D
H
H
Y
W
G
G
-
L
-
V
R
S
A
H
I
A
T
L
C
A
T
F
G
I
E
L
S
M
H
S
N
S
H
L
G
I
S
L
A
A
M
T
H
L
A
A
A
T
P
A
I
T
H
A
C
D
T
H
T
P
W
---
Q
--
D
G
-
Q
D
V
V
-
A
P
G
A
L
R
F
V
D
G
A
V
P
V
P
D
G
P
G
L
G
V
E
L
D
R
D
A
L
A
V
M
H
E
Q
Y
E
R
C
G
I
R
T
R
D
D
----------------------
77
HHSearch
60.43
33%
-84
- C1 -
3VDG
4
?
A:
[22-445]
-----------
S
M
A
H
N
R
I
R
I
T
G
A
R
V
T
P
V
A
F
A
D
P
P
L
L
N
T
V
G
V
H
Q
-
P
Y
A
L
R
A
V
I
-
Q
L
D
T
D
A
G
L
T
G
L
G
E
T
Y
A
-
D
T
-
V
H
L
E
R
L
Q
A
A
A
H
A
I
V
G
R
S
V
F
S
T
N
V
I
R
A
L
I
S
D
A
L
G
G
D
----
R
--
T
G
D
G
S
GLAGMI
T
S
A
S
V
V
D
R
V
---
F
----
S
P
F
E
V
A
C
L
D
V
Q
G
Q
V
T
G
R
P
V
S
D
L
L
G
-
G
A
V
R
D
A
V
P
F
S
A
Y
L
F
Y
K
W
A
A
------
H
P
G
--
A
E
P
D
G
W
-----
G
A
A
L
D
P
D
G
I
V
A
Q
A
R
R
M
I
D
E
Y
G
F
S
A
I
K
L
K
G
G
V
F
A
P
E
E
E
M
A
A
V
E
A
L
R
A
A
F
P
D
H
P
L
R
L
D
P
N
A
A
W
T
P
Q
T
S
V
K
V
A
A
G
L
E
G
V
L
E
Y
L
E
D
P
T
P
G
L
D
G
------
M
A
E
V
A
A
Q
A
P
M
P
L
A
T
N
M
C
V
V
A
F
D
Q
L
P
A
A
V
A
K
N
S
V
Q
V
V
L
S
D
H
H
Y
W
-
G
-
G
L
Q
R
S
R
L
L
A
G
I
C
D
T
F
G
L
G
L
S
M
H
S
N
S
H
L
G
I
S
L
A
A
M
V
H
L
A
A
A
T
P
N
L
T
Y
A
C
D
T
H
W
P
W
---
R
--
H
--
E
D
V
V
A
P
G
-
A
L
N
F
C
D
G
E
V
Q
V
P
A
T
P
G
L
G
V
E
I
D
E
D
A
L
A
A
L
H
E
Q
Y
L
R
C
G
I
R
D
R
D
D
T
G
Y
M
R
S
I
D
P
G
F
N
A
S
G
P
R
W
----
65
PsiBlast_CBE
60.26
34%
-90
- C1 -
3VDG
4
?
A:
[30-427]
-------------------
I
T
G
A
R
V
T
P
V
A
F
A
D
P
-
P
L
L
N
T
V
G
V
H
Q
P
Y
A
L
R
A
V
I
-
Q
L
D
T
D
A
G
L
T
G
L
G
E
T
Y
A
-
D
T
V
H
L
E
R
-
L
Q
A
A
A
H
A
I
V
G
R
S
V
F
S
T
N
V
I
R
A
L
I
S
D
A
L
G
G
----
D
R
T
G
D
G
S
G
L
------
A
G
M
I
T
S
A
S
V
---
V
D
R
V
F
S
P
F
E
V
A
C
L
D
V
Q
G
Q
V
T
G
R
P
V
S
D
L
L
G
-
G
A
V
R
D
A
V
P
F
S
A
Y
L
F
Y
K
W
A
A
H
P
G
A
E
P
D
--------
G
W
-----
G
A
A
L
D
P
D
G
I
V
A
Q
A
R
R
M
I
D
E
Y
G
F
S
A
I
K
L
K
G
G
V
F
A
P
E
E
E
M
A
A
V
E
A
L
R
A
A
F
P
D
H
P
L
R
L
D
P
N
A
A
W
T
P
Q
T
S
V
K
V
A
A
G
L
E
G
V
L
E
Y
L
E
D
P
T
P
G
L
D
G
------
M
A
E
V
A
A
Q
A
P
M
P
L
A
T
N
M
C
V
V
A
F
D
Q
L
P
A
A
V
A
K
N
S
V
Q
V
V
L
S
D
H
H
Y
W
-
G
G
L
-
Q
R
S
R
L
L
A
G
I
C
D
T
F
G
L
G
L
S
M
H
S
N
S
H
L
G
I
S
L
A
A
M
V
H
L
A
A
A
T
P
N
L
T
Y
A
C
D
T
H
W
P
W
---
R
--
H
E
-
D
V
V
A
-
P
G
-
A
L
N
F
C
D
G
E
V
Q
V
P
A
T
P
G
L
G
V
E
I
D
E
D
A
L
A
A
L
H
E
Q
Y
L
R
C
G
I
R
D
R
D
D
----------------------
64
PsiBlast_CBE
59.73
34%
-95
- C1 -
3VFC
3
?
A:
[30-427]
-------------------
I
T
G
A
R
V
T
P
V
A
F
A
D
P
-
P
L
L
N
T
V
G
V
H
Q
P
Y
A
L
R
A
V
I
-
Q
L
D
T
D
A
G
L
T
G
L
G
E
T
Y
A
-
D
T
V
H
L
E
R
-
L
Q
A
A
A
H
A
I
V
G
R
S
V
F
S
T
N
V
I
R
A
L
I
S
D
A
L
G
G
----
D
R
-------------
A
G
M
I
T
S
A
S
V
---
V
D
R
V
F
S
P
F
E
V
A
C
L
D
V
Q
G
Q
V
T
G
R
P
V
S
D
L
L
G
-
G
A
V
R
D
A
V
P
F
S
A
Y
L
F
Y
K
W
A
A
H
P
G
A
E
P
D
--------
G
W
-----
G
A
A
L
D
P
D
G
I
V
A
Q
A
R
R
M
I
D
E
Y
G
F
S
A
I
K
L
K
G
G
V
F
A
P
E
E
E
M
A
A
V
E
A
L
R
A
A
F
P
D
H
P
L
R
L
D
P
N
A
A
W
T
P
Q
T
S
V
K
V
A
A
G
L
E
G
V
L
E
Y
L
E
D
P
T
P
G
L
D
G
------
M
A
E
V
A
A
Q
A
P
M
P
L
A
T
N
M
C
V
V
A
F
D
Q
L
P
A
A
V
A
K
N
S
V
Q
V
V
L
S
D
H
H
Y
W
-
G
G
L
-
Q
R
S
R
L
L
A
G
I
C
D
T
F
G
L
G
L
S
M
H
S
N
S
H
L
G
I
S
L
A
A
M
V
H
L
A
A
A
T
P
N
L
T
Y
A
C
D
T
H
W
P
W
---
R
--
H
E
-
D
V
V
A
-
P
G
-
A
L
N
F
C
D
G
E
V
Q
V
P
A
T
P
G
L
G
V
E
I
D
E
D
A
L
A
A
L
H
E
Q
Y
L
R
C
G
I
R
D
R
D
D
----------------------
83
HHSearch
57.70
35%
-82
- C1 -
3VA8
3
?
A:
[20-433]
----------
F
Q
S
M
S
Q
R
S
I
I
K
E
I
V
I
T
P
V
A
F
H
D
M
-
P
L
L
N
S
V
G
V
H
E
P
F
A
L
R
S
I
I
-
E
I
I
T
E
-
D
S
Y
G
L
G
E
S
Y
G
-
D
S
-
A
H
L
D
R
L
Q
K
A
A
D
K
I
K
G
L
S
V
Y
S
T
N
V
I
Y
Q
R
C
V
E
S
L
R
N
D
TN---
G
-
D
G
M
G
G
MV----
V
T
A
S
V
A
D
K
V
---
F
----
S
P
F
E
V
A
C
L
D
L
Q
G
K
L
A
G
I
S
V
S
D
L
L
G
-
G
R
V
R
D
S
V
Q
Y
S
A
Y
L
F
Y
K
W
G
G
------
H
P
G
--
D
E
D
D
E
Y
-----
G
P
A
L
D
P
E
G
V
V
K
Q
A
K
K
I
I
D
E
Y
G
F
K
A
I
K
L
K
G
G
V
F
P
P
A
D
E
V
A
A
I
K
A
L
H
K
A
F
P
G
V
P
L
R
L
D
P
N
A
A
W
T
V
E
T
S
K
W
V
A
K
E
L
E
G
I
V
E
Y
L
E
D
P
A
G
E
I
------
E
G
M
A
A
V
A
K
E
A
S
M
P
L
A
T
N
M
A
V
V
A
F
D
H
L
P
P
S
I
L
Q
D
A
V
Q
V
I
L
S
D
H
H
F
W
-
G
-
G
L
R
K
S
Q
T
L
A
S
I
C
A
T
W
G
L
R
L
S
M
H
S
N
S
H
L
G
I
S
L
A
A
M
T
H
L
A
S
A
T
P
N
L
D
Y
A
C
D
T
H
W
P
W
KRR
D
--
E
--
D
V
V
I
-
E
G
-
A
L
K
W
K
D
G
G
V
I
V
P
S
G
P
G
L
G
V
E
L
D
R
E
R
L
A
K
L
H
Q
Q
Y
V
D
C
G
L
K
K
R
D
D
T
T
Y
M
K
R
----------------
63
PsiBlast_CBE
56.61
34%
-83
- C1 -
3VA8
3
?
A:
[29-443]
-------------------
I
K
E
I
V
I
T
P
V
A
F
H
D
M
-
P
L
L
N
S
V
G
V
H
E
P
F
A
L
R
S
I
I
E
I
I
T
E
D
S
--
Y
G
L
G
E
S
Y
G
D
S
A
-
H
L
D
R
-
L
Q
K
A
A
D
K
I
K
G
L
S
V
Y
S
T
N
V
I
Y
Q
R
C
V
E
S
L
R
N
D
---
T
N
--
G
D
G
M
G
------
G
M
V
V
T
A
S
V
A
D
K
V
F
----
S
P
F
E
V
A
C
L
D
L
Q
G
K
L
A
G
I
S
V
S
D
L
L
G
-
G
R
V
R
D
S
V
Q
Y
S
A
Y
L
F
Y
K
W
G
G
H
----
P
G
D
E
D
D
E
---------
Y
G
P
A
L
D
P
E
G
V
V
K
Q
A
K
K
I
I
D
E
Y
G
F
K
A
I
K
L
K
G
G
V
F
P
P
A
D
E
V
A
A
I
K
A
L
H
K
A
F
P
G
V
P
L
R
L
D
P
N
A
A
W
T
V
E
T
S
K
W
V
A
K
E
L
E
G
I
V
E
Y
L
E
D
P
A
G
E
I
E
G
------
M
A
A
V
A
K
E
A
S
M
P
L
A
T
N
M
A
V
V
A
F
D
H
L
P
P
S
I
L
Q
D
A
V
Q
V
I
L
S
D
H
H
F
W
G
G
-
L
-
R
K
S
Q
T
L
A
S
I
C
A
T
W
G
L
R
L
S
M
H
S
N
S
H
L
G
I
S
L
A
A
M
T
H
L
A
S
A
T
P
N
L
D
Y
A
C
D
T
H
W
P
W
---
K
RR
D
E
-
D
V
V
I
-
E
G
-
A
L
K
W
K
D
G
G
V
I
V
P
S
G
P
G
L
G
V
E
L
D
R
E
R
L
A
K
L
H
Q
Q
Y
V
D
C
G
L
K
K
R
D
D
T
T
Y
M
K
R
F
K
P
--
E
F
S
E
K
I
P
----