@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03040: (2016-06-05 )
MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTAPSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWLYQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPNWTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDAAKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSIRSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVIASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEELSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGKLTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQINNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIGYQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVIFNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH
Atome Classification :
(20 SA)
.........10........20........30........40........50-.--........60...-...-..-70........80....--....90........100.......110.......120.......130.......140...-----------....----------150------------....----.-----.-------------..-----160---.-------..-------..-----..--170........180.......190.......200.......210.......220.....--------..230......------.240-----------.------------........250......--..--.260.......270.......280----..-.-....290..---.---.---...300.......310.......-.----320-.........330-......-.-340....---------.-----------------------..350--..------------------.------....--360..--------.----.-----.---..370----.----......380....---..-.390...-.-.-..400.......410........420.......430.......440--------.---------.-----------...-...450-.....---.---.460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
F
A
K
R
F
K
T
S
L
L
P
L
F
A
G
F
L
L
L
F
H
L
V
LAGPAAASAETANKSNELTAPSIKS
G
--
T
--
I
L
H
A
WNWS
F
N
T
L
K
-
H
N
M
-
K
D
-
I
H
D
AGY
T
A
IQTSP
I
N
Q
--
V
KEGNQGDKSMS
N
W
Y
W
L
YQPTS
Y
Q
IGNRYLG
T
E
Q
E
F
K
E
M
C
A
A
A
E
EYG
I
K
V
I
V
D
A
V
INHTT-----------
S
D
Y
A
----------
A
I
-------------
S
N
E
V
----
K
-----S-------------IP-----NWT---H-------GN-------TQ-----IK--NW-SDRWDVTQN
S
L
L
G
L
Y
DWNTQ
N
T
Q
V
Q
S
Y
L
K
R
F
L
D
R
ALNDGADG
F
R
FDA
A
K
HIELPDD--------GSYGSQFWPNI------TN-------------T------------SAEF
Q
Y
G
E
I
--
L
Q
DSAS--RD--AAY
A
N
Y
M
D
V
T
A
SNY
G
H
S
I
R
S
A
L
KN----RN-L-G
V
S
N
I
S
H
Y
A---S---D---V
S
A
D
K
L
V
T
W
V
E
SHDT-YANDDEE-S----T---WMSDDD
I
R
L
G
W
A
-
V
I
ASRS-G-ST
P
L
F
F
S---------R-----------------------PEGGG--NG------------------V------RFPG--KSQIG--------D----R-----G---S
A
L
F
E
----
D
----
Q
A
I
T
A
V
N
R
F
H
N
V
M---AG-Q
P
E
ELSN-P-N-GN
N
Q
I
F
M
NQRGSH
G
-
V
V
L
ANAGS
S
S
V
S
I
N
T
ATKLPDGRYDNKAGA---------G---------
S
-----------
F
Q
V-NDG
K
L
T
-
G
T
I
NA---
R
---
S
V
A
V
LY
P
D
D
IAKA
P
H
V
F
L
E
NYKTGVTHSFND
Q
L
T
I
T
L
RADANT
T
K
A
V
Y
Q
INNGPETAFKDGD
Q
F
TIGKGDPFG
K
T
Y
T
I
M
L
KGTNSDGVTRT
E
K
Y
S
F
VKRDPASAKTIGYQNPNHWSQ
V
N
A
Y
I
Y
KHDG
S
R
V
I
E
L
TGSWPGKPMTKNAD
G
I
Y
T
L
T
LPADTDTT
N
A
K
V
I
FNNGSAQVPGQNQP
G
F
D
Y
V
L
N
G
LYNDSGLSGSLPH
1
PsiBlast_PDB
86.14
99%
-51
- C2 -
1BAG
4
AMY_BACSU
A:
[1-425]
-----------------------------------------
L
T
A
P
S
I
K
S
G
--
T
--
I
L
H
A
W
N
W
S
F
N
T
L
K
-
H
N
M
-
K
D
-
I
H
D
A
G
Y
T
A
I
Q
T
S
P
I
N
Q
--
V
K
E
G
N
Q
G
D
K
S
M
S
N
W
Y
W
L
Y
Q
P
T
S
Y
Q
I
G
N
R
Y
L
G
T
E
Q
E
F
K
E
M
C
A
A
A
E
E
Y
G
I
K
V
I
V
D
A
V
I
N
H
T
T
-----------
F
D
Y
A
----------
A
I
-------------
S
N
E
V
----
K
-----
S
-------------
I
P
-----
N
W
T
---
H
-------
G
N
-------
T
Q
-----
I
K
--
N
W
-
S
D
R
W
D
V
T
Q
N
S
L
L
G
L
Y
D
W
N
T
Q
N
T
Q
V
Q
S
Y
L
K
R
F
L
E
R
A
L
N
D
G
A
D
G
F
R
F
D
A
A
K
H
I
E
L
P
D
D
--------
G
S
Y
G
S
Q
F
W
P
N
I
------
T
N
-------------
T
------------
S
A
E
F
Q
Y
G
Q
I
--
L
Q
D
S
A
S
--
R
D
--
A
A
Y
A
N
Y
M
D
V
T
A
S
N
Y
G
H
S
I
R
S
A
L
K
N
----
R
N
-
L
-
G
V
S
N
I
S
H
Y
A
---
S
---
D
---
V
S
A
D
K
L
V
T
W
V
E
S
H
D
T
-
Y
A
N
D
D
E
E
-
S
----
T
---
W
M
S
D
D
D
I
R
L
G
W
A
-
V
I
A
S
R
S
-
G
-
S
T
P
L
F
F
S
---------
R
-----------------------
P
E
G
G
G
--
N
G
------------------
V
------
R
F
P
G
--
K
S
Q
I
G
--------
D
----
R
-----
G
---
S
A
L
F
E
----
D
----
Q
A
I
T
A
V
N
R
F
H
N
V
M
---
A
G
-
Q
P
E
E
L
S
N
-
P
-
N
-
G
N
N
Q
I
F
M
N
Q
R
G
S
H
G
-
V
V
L
A
N
A
G
S
S
S
V
S
I
N
T
A
T
K
L
P
D
G
R
Y
D
N
K
A
G
A
---------
G
---------
S
-----------
F
Q
V
-
N
D
G
K
L
T
-
G
T
I
N
A
---
R
---
S
V
A
V
L
Y
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.63
99%
-46
- C2 -
1UA7
4
AMY_BACSU
A:
[1-422]
--------------------------------------------
P
S
I
K
S
G
--
T
--
I
L
H
A
W
N
W
S
F
N
T
L
K
-
H
N
M
-
K
D
-
I
H
D
A
G
Y
T
A
I
Q
T
S
P
I
N
Q
--
V
K
E
G
N
Q
G
D
K
S
M
S
N
W
Y
W
L
Y
Q
P
T
S
Y
Q
I
G
N
R
Y
L
G
T
E
Q
E
F
K
E
M
C
A
A
A
E
E
Y
G
I
K
V
I
V
D
A
V
I
N
H
T
T
-----------
F
D
Y
A
----------
A
I
-------------
S
N
E
V
----
K
-----
S
-------------
I
P
-----
N
W
T
---
H
-------
G
N
-------
T
Q
-----
I
K
--
N
W
-
S
D
R
W
D
V
T
Q
N
S
L
L
G
L
Y
D
W
N
T
Q
N
T
Q
V
Q
S
Y
L
K
R
F
L
E
R
A
L
N
D
G
A
D
G
F
R
F
D
A
A
K
H
I
E
L
P
D
D
--------
G
S
Y
G
S
Q
F
W
P
N
I
------
T
N
-------------
T
------------
S
A
E
F
Q
Y
G
E
I
--
L
Q
D
S
A
S
--
R
D
--
A
A
Y
A
N
Y
M
D
V
T
A
S
N
Y
G
H
S
I
R
S
A
L
K
N
----
R
N
-
L
-
G
V
S
N
I
S
H
Y
A
---
S
---
D
---
V
S
A
D
K
L
V
T
W
V
E
S
H
D
T
-
Y
A
N
D
D
E
E
-
S
----
T
---
W
M
S
D
D
D
I
R
L
G
W
A
-
V
I
A
S
R
S
-
G
-
S
T
P
L
F
F
S
---------
R
-----------------------
P
E
G
G
G
--
N
G
------------------
V
------
R
F
P
G
--
K
S
Q
I
G
--------
D
----
R
-----
G
---
S
A
L
F
E
----
D
----
Q
A
I
T
A
V
N
R
F
H
N
V
M
---
A
G
-
Q
P
E
E
L
S
N
-
P
-
Q
-
G
N
N
Q
I
F
M
N
Q
R
G
S
H
G
-
V
V
L
A
N
A
G
S
S
S
V
S
I
N
T
A
T
K
L
P
D
G
R
Y
D
N
K
A
G
A
---------
G
---------
S
-----------
F
Q
V
-
N
D
G
K
L
T
-
G
T
I
N
A
---
R
---
S
V
A
V
L
Y
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.72
94%
-50
- C2 -
3DC0
3
?
A:
[1-422]
--------------------------------------------
P
S
I
K
S
G
--
T
--
I
L
H
A
W
N
W
S
F
N
T
L
K
-
N
N
M
-
K
D
-
I
H
D
A
G
Y
T
A
I
Q
T
S
P
I
N
Q
--
V
K
E
G
N
K
G
D
K
S
M
G
N
W
Y
W
L
Y
Q
P
T
S
Y
Q
I
G
N
R
Y
L
G
S
E
E
E
F
K
E
M
C
A
A
A
E
E
Y
G
V
K
V
I
V
D
A
V
I
N
H
T
T
-----------
S
D
Y
A
----------
A
I
-------------
S
N
E
I
----
K
-----
S
-------------
I
S
-----
N
W
T
---
H
-------
G
N
-------
T
Q
-----
I
K
--
N
W
-
S
D
R
W
D
V
T
Q
N
S
L
L
G
L
Y
D
W
N
T
Q
N
T
Q
V
Q
S
Y
L
K
R
F
L
E
R
A
L
N
D
G
A
D
G
F
R
Y
D
A
A
K
H
I
E
L
P
D
D
--------
G
N
Y
G
S
Q
F
W
P
N
I
------
T
N
-------------
T
------------
S
A
E
F
Q
Y
G
E
I
--
L
Q
D
S
A
S
--
R
D
--
A
A
Y
A
N
Y
M
N
V
T
A
S
N
Y
G
H
S
I
R
S
A
L
K
N
----
R
N
-
L
-
S
V
S
N
I
S
H
Y
A
---
S
---
D
---
V
S
A
D
K
L
V
T
W
V
E
S
H
D
T
-
Y
A
N
D
D
E
E
-
S
----
T
---
W
M
S
D
D
D
I
R
L
G
W
A
-
V
I
A
S
R
S
-
G
-
S
T
P
L
F
F
S
---------
R
-----------------------
P
D
G
G
G
--
N
G
------------------
V
------
R
F
P
G
--
K
T
Q
I
G
--------
D
----
R
-----
G
---
S
A
L
F
E
----
D
----
Q
A
I
V
A
V
N
T
F
H
N
V
M
---
A
G
-
Q
P
E
E
L
S
N
-
P
-
N
-
G
N
N
Q
I
F
M
N
Q
R
G
S
K
G
-
V
V
L
A
N
A
G
S
S
S
V
S
I
N
A
S
T
K
L
P
D
G
S
Y
D
N
K
A
G
T
---------
G
---------
S
-----------
F
Q
V
-
R
D
G
K
L
T
-
G
T
I
N
A
---
R
---
S
V
A
V
L
Y
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
82.60
96%
-50
- C2 -
1UA7
4
AMY_BACSU
A:
[3-421]
----------------------------------------------
I
K
S
G
--
T
--
I
L
H
A
W
N
W
S
F
N
T
L
K
-
H
N
M
-
K
D
-
I
H
D
A
G
Y
T
A
I
Q
T
S
P
I
N
Q
--
V
K
E
G
N
Q
G
D
K
S
M
S
N
W
Y
W
L
Y
Q
P
T
S
Y
Q
I
G
N
R
Y
L
G
T
E
Q
E
F
K
E
M
C
A
A
A
E
E
Y
G
I
K
V
I
V
D
A
V
I
N
H
T
T
-----------
F
D
Y
A
----------
A
I
-------------
S
N
E
V
----
K
-----
S
-------------
I
P
-----
N
W
T
---
H
-------
G
N
-------
T
Q
-----
I
K
--
N
W
-
S
D
R
W
D
V
T
Q
N
S
L
L
G
L
Y
D
W
N
T
Q
N
T
Q
V
Q
S
Y
L
K
R
F
L
E
R
A
L
N
D
G
A
D
G
F
R
F
D
A
A
K
H
I
E
L
P
D
D
--------
G
S
Y
G
S
Q
F
W
P
N
I
------
T
N
-------------
T
------------
S
A
E
F
Q
Y
G
E
I
--
L
Q
D
S
A
S
--
R
D
--
A
A
Y
A
N
Y
M
D
V
T
A
S
N
Y
G
H
S
I
R
S
A
L
K
N
----
R
N
-
L
-
G
V
S
N
I
S
H
Y
A
---
S
---
D
---
V
S
A
D
K
L
V
T
W
V
E
S
H
D
T
-
Y
A
N
D
D
E
E
-
S
----
T
---
W
M
S
D
D
D
I
R
L
G
W
A
-
V
I
A
S
R
S
-
G
S
T
P
L
F
F
S
R
---------------------------------
P
E
G
G
G
--
N
G
------------------
V
------
R
F
P
G
--
K
S
Q
I
G
--------
D
----
R
-----
G
---
S
A
L
F
E
----
D
----
Q
A
I
T
A
V
N
R
F
H
N
V
M
---
A
G
-
Q
P
E
E
L
S
N
-
P
-
Q
G
N
N
Q
I
F
M
N
Q
-
R
G
S
H
G
-
V
V
L
A
N
A
G
S
S
S
V
S
I
N
T
A
T
K
L
P
D
G
R
Y
D
N
K
A
G
A
---------
G
---------
S
-----------
F
Q
V
-
N
D
G
K
L
T
-
G
T
I
N
A
---
R
---
S
V
A
V
L
Y
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
50.95
23%
-55
- C2 -
1DHK
3
AMYP_PIG
A:
[3-449]
-------------------------------------------
A
P
Q
T
Q
S
G
RT
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
G
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
V
V
V
T
N
P
S
R
P
---
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
N
E
F
R
D
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
S
G
A
----------
A
A
GTGTTCG
S
Y
C
N
PG
S
R
E
F
----
P
-----
A
-------------
V
P
YSAW-
D
F
N
---
D
-------
G
K
-------
C
K
TASGG
I
E
--
S
Y
-
N
D
P
Y
Q
V
R
D
C
Q
L
V
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
M
I
A
D
Y
L
N
K
L
I
D
I
G
V
A
G
F
R
I
D
A
S
K
H
M
W
P
G
D
I
--------
K
A
V
L
D
K
L
H
N
L
N
------
T
N
WFPA---------
G
------------
S
R
P
F
I
F
Q
E
V
I
D
L
G
G
E
A
I
--
Q
S
--
S
E
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
V
R
K
WSGE
K
M
-
S
-
Y
L
K
N
W
G
E
G
W
---
G
---
F
---
M
P
S
D
R
A
L
V
F
V
D
N
H
D
N
Q
R
G
H
G
A
G
G
-
A
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
V
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
ARNFVNGEDVNDWIGP
P
N
N
N
G
VI
K
E
------------------
V
------
T
I
N
A
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
E
I
R
N
M
V
W
F
R
N
V
V
---
D
G
-
Q
P
F
A
N
W
W
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
Q
L
S
S
T
L
Q
T
G
L
P
G
G
T
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.64
23%
-49
- C2 -
1KXQ
2
AMYP_PIG
A:
[3-449]
-------------------------------------------
A
P
Q
T
Q
S
G
RT
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
G
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
I
V
V
T
N
P
S
R
P
---
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
N
E
F
R
D
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
S
G
A
----------
A
A
GTGTTCG
S
Y
C
N
PG
S
R
E
F
----
P
-----
A
-------------
V
P
YSAW-
D
F
N
---
D
-------
G
K
-------
C
K
TASGG
I
E
--
S
Y
-
N
D
P
Y
Q
V
R
D
C
Q
L
V
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
M
I
A
D
Y
L
N
K
L
I
D
I
G
V
A
G
F
R
I
D
A
S
K
H
M
W
P
G
D
I
--------
K
A
V
L
D
K
L
H
N
L
N
------
T
N
WFPA---------
G
------------
S
R
P
F
I
F
Q
E
V
I
D
L
G
G
E
A
I
--
K
S
--
S
E
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
V
R
K
WSGE
K
M
-
S
-
Y
L
K
N
W
G
E
G
W
---
G
---
F
---
M
P
S
D
R
A
L
V
F
V
D
N
H
D
N
Q
R
G
H
G
A
G
G
-
S
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
I
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
A
R
N
F
V
NGEDVNDWIGP
P
N
N
N
G
VI
K
E
------------------
V
------
T
I
N
A
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
E
I
R
N
M
V
W
F
R
N
V
V
---
D
G
-
Q
P
F
A
N
W
W
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
Q
L
S
S
T
L
Q
T
G
L
P
G
G
T
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
50.63
23%
-51
- C2 -
1PPI
3
AMYP_PIG
A:
[3-449]
-------------------------------------------
A
P
Q
T
Q
S
G
R
T
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
G
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
V
V
V
T
N
P
S
R
P
---
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
N
E
F
R
D
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
S
G
A
----------
A
A
GTGTTCGSYCNPG
S
R
E
F
----
P
-----
A
-------------
V
P
YSAW-
D
F
N
---
D
-------
G
K
-------
C
K
TASGG
I
E
--
S
Y
-
N
D
P
Y
Q
V
R
D
C
Q
L
V
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
M
I
A
D
Y
L
N
K
L
I
D
I
G
V
A
G
F
R
I
D
A
S
K
H
M
W
P
G
D
I
--------
K
A
V
L
D
K
L
H
N
L
N
------
T
N
WFPA---------
G
------------
S
R
P
F
I
F
Q
E
V
I
D
L
G
G
E
A
I
--
K
S
--
S
E
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
V
R
K
WSGE
K
M
-
S
-
Y
L
K
N
W
G
E
G
W
---
G
---
F
---
M
P
S
D
R
A
L
V
F
V
D
N
H
D
N
Q
R
G
H
G
A
G
G
-
S
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
V
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
A
R
N
F
V
NGEDVNDWIGP
P
N
N
N
G
VI
K
E
------------------
V
------
T
I
N
A
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
E
I
R
N
M
V
W
F
R
N
V
V
---
D
G
-
E
P
F
A
N
W
W
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
Q
L
S
S
T
L
Q
T
G
L
P
G
G
T
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
50.54
23%
-51
- C2 -
1KXV
-
AMYP_PIG
A:
[3-449]
-------------------------------------------
A
P
Q
T
Q
S
G
R
T
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
G
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
I
V
V
T
N
P
S
R
P
---
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
N
E
F
R
D
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
S
G
A
----------
A
A
G
TGTTCG
S
Y
C
N
PG
S
R
E
F
----
P
-----
A
-------------
V
P
YSAW-
D
F
N
---
D
-------
G
K
-------
C
K
TASGG
I
E
--
S
Y
-
N
D
P
Y
Q
V
R
D
C
Q
L
V
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
M
I
A
D
Y
L
N
K
L
I
D
I
G
V
A
G
F
R
I
D
A
S
K
H
M
W
P
G
D
I
--------
K
A
V
L
D
K
L
H
N
L
N
------
T
N
WFPA---------
G
------------
S
R
P
F
I
F
Q
E
V
ID
L
G
G
E
A
I
--
K
S
--
S
E
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
V
R
K
WSGE
K
M
-
S
-
Y
L
K
N
W
G
E
G
W
---
G
---
F
---
M
P
S
D
R
A
L
V
F
V
D
N
H
D
N
Q
R
G
H
G
A
G
G
-
S
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
I
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
A
R
N
F
V
NGEDVNDWIGP
P
N
N
N
G
VI
K
E
------------------
V
------
T
I
N
A
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
E
I
R
N
M
V
W
F
R
N
V
V
---
D
G
-
Q
P
F
A
N
W
W
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
Q
L
S
S
T
L
Q
T
G
L
P
G
G
T
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
49.64
23%
-47
- C2 -
1KXT
2
AMYP_PIG
A:
[3-449]
-------------------------------------------
A
P
Q
T
Q
S
G
RT
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
G
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
I
V
V
T
N
P
S
R
P
---
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
N
E
F
R
D
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
S
G
A
----------
A
A
G
TGTTCG
S
Y
C
N
PG
S
R
E
F
----
P
-----
A
-------------
V
P
YSAW-
D
F
N
---
D
-------
G
K
-------
C
K
TASGG
I
E
--
S
Y
-
N
D
P
Y
Q
V
R
D
C
Q
L
V
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
M
I
A
D
Y
L
N
K
L
I
D
I
G
V
A
G
F
R
I
D
A
S
K
H
M
W
P
G
D
I
--------
K
A
V
L
D
K
L
H
N
L
N
------
T
N
WFPA---------
G
------------
S
R
P
F
I
F
Q
E
V
ID
L
G
G
E
A
I
--
K
S
--
S
E
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
V
R
K
WSGE
K
M
-
S
-
Y
L
K
N
W
G
E
G
W
---
G
---
F
---
M
P
S
D
R
A
L
V
F
V
D
N
H
D
N
Q
R
G
H
G
A
G
G
-
S
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
I
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
A
R
N
F
V
NGEDVNDWIGP
P
N
N
N
G
V
I
K
E
------------------
V
------
T
I
N
A
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
E
I
R
N
M
V
W
F
R
N
V
V
---
D
G
-
Q
P
F
A
N
W
W
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
Q
L
S
S
T
L
Q
T
G
L
P
G
G
T
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
49.37
23%
-51
- C2 -
1BVN
2
AMYP_PIG
P:
[3-451]
-------------------------------------------
A
P
Q
T
Q
S
G
--
R
TD
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
G
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
V
V
V
T
N
P
S
R
P
---
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
N
E
F
R
D
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
S
G
A
----------
A
A
GTGTTCGSYCNPG
S
R
E
F
----
P
-----
A
-------------
V
P
YSAW-
D
F
N
---
D
-------
G
K
-------
C
K
TASGG
I
E
--
S
Y
-
N
D
P
Y
Q
V
R
D
C
Q
L
V
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
M
I
A
D
Y
L
N
K
L
I
D
I
G
V
A
G
F
R
L
D
A
S
K
H
M
W
P
G
D
I
--------
K
A
V
L
D
K
L
H
N
L
N
------
T
N
WFPA---------
G
------------
S
R
P
F
I
F
Q
E
V
ID
L
G
G
E
A
I
--
S
S
--
S
E
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
V
R
K
WSGE
K
M
-
S
-
Y
L
K
N
W
G
E
G
W
---
G
---
F
---
M
P
S
D
R
A
L
V
F
V
D
N
H
D
N
Q
R
G
H
G
A
G
G
-
S
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
V
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
VMSSYRWARNFVNGEDVNDWIGP
P
N
N
N
G
VI
K
E
------------------
V
------
T
I
N
A
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
E
I
R
N
M
V
W
F
R
N
V
V
---
D
G
-
Q
P
F
A
N
W
W
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
Q
L
S
S
T
L
Q
T
G
L
P
G
G
T
Y
C
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
48.64
23%
-50
- C2 -
1PIG
8
AMYP_PIG
A:
[3-451]
-------------------------------------------
A
P
Q
T
Q
S
G
RT
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
G
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
V
V
V
T
N
P
S
R
P
---
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
N
E
F
R
D
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
S
G
A
----------
A
A
GTGTTCG
S
Y
C
N
PG
S
R
E
F
----
P
-----
A
-------------
V
P
YSAW-
D
F
N
---
D
-------
G
K
-------
C
K
TASGG
I
E
--
S
Y
-
N
D
P
Y
Q
V
R
D
C
Q
L
V
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
M
I
A
D
Y
L
N
K
L
I
D
I
G
V
A
G
F
R
I
D
A
S
K
H
M
W
P
G
D
I
--------
K
A
V
L
D
K
L
H
N
L
N
------
T
N
WFPA---------
G
------------
S
R
P
F
I
F
Q
E
V
ID
L
G
G
E
A
I
--
S
S
--
S
E
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
V
R
K
WSGE
K
M
-
S
-
Y
L
K
N
W
G
E
G
W
---
G
---
F
---
M
P
S
D
R
A
L
V
F
V
D
N
H
D
N
Q
R
G
H
G
A
G
G
-
S
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
V
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
A
R
N
F
V
NGEDVNDWIGP
P
N
N
N
G
V
I
K
E
------------------
V
------
T
I
N
A
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
E
I
R
N
M
V
W
F
R
N
V
V
---
D
G
-
Q
P
F
A
N
W
W
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
Q
L
S
S
T
L
Q
T
G
L
P
G
G
T
Y
C
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.29
23%
-48
- C2 -
4X0N
3
AMYP_PIG
A:
[3-451]
-------------------------------------------
A
P
Q
T
Q
S
G
RT
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
G
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
V
V
V
T
N
P
S
R
P
---
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
N
E
F
R
D
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
S
G
A
----------
A
A
G
TGTTCG
S
Y
C
N
PG
S
R
E
F
----
P
-----
A
-------------
V
P
YSAW-
D
F
N
---
D
-------
G
K
-------
C
K
TASGG
I
E
--
S
Y
-
N
D
P
Y
Q
V
R
D
C
Q
L
V
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
M
I
A
D
Y
L
N
K
L
I
D
I
G
V
A
G
F
R
I
D
A
S
K
H
M
W
P
G
D
I
--------
K
A
V
L
D
K
L
H
N
L
N
------
T
N
WFPA---------
G
------------
S
R
P
F
I
F
Q
E
V
I
D
L
G
G
E
A
I
--
S
S
--
S
E
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
V
R
K
WSGE
K
M
-
S
-
Y
L
K
N
W
G
E
G
W
---
G
---
F
---
M
P
S
D
R
A
L
V
F
V
D
N
H
D
N
Q
R
G
H
G
A
G
G
-
S
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
V
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
A
R
N
F
V
NGEDVNDWIGP
P
N
N
N
G
V
I
K
E
------------------
V
------
T
I
N
A
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
E
I
R
N
M
V
W
F
R
N
V
V
---
D
G
-
Q
P
F
A
N
W
W
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
Q
L
S
S
T
L
Q
T
G
L
P
G
G
T
Y
C
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
47.84
22%
-66
- C2 -
1JAE
2
AMY_TENMO
A:
[4-469]
------------------------------------------
A
N
F
A
S
G
R
N
--
S
--
I
V
H
L
F
E
W
K
W
N
D
I
A
-
D
E
C
E
R
F
-
L
Q
P
Q
G
F
G
G
V
Q
I
S
P
P
N
E
--
Y
L
V
A
-----
D
G
R
P
W
W
E
R
Y
Q
P
V
S
Y
I
-
I
N
T
R
S
G
D
E
S
A
F
T
D
M
T
R
R
C
N
D
A
G
V
R
I
Y
V
D
A
V
I
N
H
M
T
-----------
G
M
N
G
----------
V
G
-------------
T
S
G
S
----
S
-----
A
DHDGMNYPAVPYG
S
G
-----
D
F
H
---
S
--------
P
-------
C
E
-----
V
N
--
N
Y
-
Q
D
A
D
N
V
R
N
C
E
L
V
G
L
R
D
L
N
Q
G
S
D
Y
V
R
G
V
L
I
D
Y
M
N
H
M
I
D
L
G
V
A
G
F
R
V
D
A
A
K
H
M
S
P
G
----------------
D
L
S
V
I
------
F
S
G
LKNLNTDYGFAD
G
------------
A
R
P
F
I
Y
Q
E
V
--
I
D
L
G
G
E
--
A
I
SK
N
E
Y
T
G
F
G
C
V
L
E
F
Q
F
G
V
S
L
G
N
A
F
Q
G
----
G
N
---
Q
L
K
N
L
A
N
W
G
---
P
EWG
L
---
L
E
G
L
D
A
V
V
F
V
D
N
H
D
N
-
Q
R
T
G
G
S
Q
I
L
----
T
---
Y
K
N
P
K
P
Y
K
M
A
I
A
-
F
M
L
A
H
P
Y
G
-
T
T
R
I
M
S
S
---------
F
------------------------
D
F
T
D
--
N
D
------------------
Q
------
G
P
P
Q
DG
S
G
N
L
I
--------
S
PGIN
D
-----
D
NTC
S
N
G
Y
V
CEHR
W
----
R
Q
V
Y
G
M
V
G
F
R
N
A
V
---
E
G
T
Q
V
E
N
W
W
S
N
D
-
D
-
N
Q
I
A
F
S
R
G
--
S
Q
G
F
-
V
A
F
T
N
G
G
D
L
N
Q
N
L
N
--
T
G
L
P
A
G
T
Y
C
D
V
I
S
G
ELSGGSCT
G
K
---------
S
-----------
V
T
V
G
D
N
G
S
A
D
-
I
S
L
G
S
---
A
EDD
G
V
L
A
I
H
V
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
47.21
23%
-47
- C2 -
1PIF
2
AMYP_PIG
A:
[3-451]
-------------------------------------------
A
P
Q
T
Q
S
G
RT
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
G
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
V
V
V
T
N
P
S
R
P
---
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
N
E
F
R
D
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
S
G
A
----------
A
A
GTGTTCG
S
Y
C
N
PG
S
R
E
F
----
P
-----
A
-------------
V
P
YSAW-
D
F
N
---
D
-------
G
K
-------
C
K
TASGG
I
E
--
S
Y
-
N
D
P
Y
Q
V
R
D
C
Q
L
V
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
M
I
A
D
Y
L
N
K
L
I
D
I
G
V
A
G
F
R
I
D
A
S
K
H
M
W
P
G
D
I
--------
K
A
V
L
D
K
L
H
N
L
N
------
T
N
WFPA---------
G
------------
S
R
P
F
I
F
Q
E
V
ID
L
G
G
E
A
I
--
S
S
--
S
E
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
V
R
K
WSGE
K
M
-
S
-
Y
L
K
N
W
G
E
G
W
---
G
---
F
---
M
P
S
D
R
A
L
V
F
V
D
N
H
D
N
Q
R
G
H
G
A
G
G
-
S
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
V
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
A
R
N
F
V
NGEDVNDWIGP
P
N
N
N
G
V
I
K
E
------------------
V
------
T
I
N
A
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
E
I
R
N
M
V
W
F
R
N
V
V
---
D
G
-
Q
P
F
A
N
W
W
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
Q
L
S
S
T
L
Q
T
G
L
P
G
G
T
Y
C
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
46.34
22%
-61
- C2 -
4X9Y
2
AMYP_HUMAN
A:
[4-494]
------------------------------------------
P
N
T
Q
Q
G
R
T
--
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
L
E
C
E
-
R
Y
-
L
A
P
K
G
F
G
G
V
Q
V
S
P
P
N
E
--
N
V
A
I
Y
---
N
P
F
R
P
W
W
E
R
Y
Q
P
V
S
Y
-
K
L
C
T
R
S
G
N
E
D
E
F
R
N
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
N
A
V
SAGTSSTCG
S
Y
F
-------------
N
P
G
S
----
R
DFPAV
P
-------------
Y
S
-----
G
W
D
---
F
-------
N
D
GKCKTGS
G
D
-----
I
E
--
N
Y
-
N
D
A
T
Q
V
R
D
C
R
L
T
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
K
I
A
E
Y
M
N
H
L
I
D
I
G
V
A
G
F
R
L
D
A
S
K
H
M
W
P
----------------
G
D
I
K
A
I
------
L
D
-------------
K
LHNLNSNWFPAG
S
K
P
F
I
Y
Q
E
V
--
I
D
L
G
G
E
PI
K
S
--
S
D
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
I
R
K
----
W
N
-
G
E
K
M
S
Y
L
K
N
W
G
EGW
G
---
F
---
V
P
S
D
R
A
L
V
F
V
D
N
H
D
N
-
Q
R
G
H
G
A
G
-
G
ASIL
T
---
F
W
D
A
R
L
Y
K
M
A
V
G
-
F
M
L
A
H
P
Y
G
-
F
T
R
V
M
S
S
Y
R
-------
W
-----------------------
P
R
Q
F
Q
--
N
G
------------------
N
DVNDWV
G
P
P
N
--
N
N
G
V
I
K
E
V
T
I
N
PD
T
----
T
-----
C
---
G
N
D
W
V
CEHR
W
----
R
Q
I
R
N
M
V
I
F
R
N
V
V
D--
G
Q
-
P
F
T
N
W
Y
D
-
N
G
S
-
N
Q
V
A
F
G
R
G
---
N
R
G
-
F
I
V
F
N
N
D
D
W
S
F
S
L
T
L
Q
T
G
L
P
A
G
T
Y
C
D
V
I
S
G
---------
D
KINGNCT
G
I
K
-----------
I
Y
V
S
D
D
G
K
A
H
-
F
S
I
S
N
SAE
D
---
P
F
I
A
I
H
A
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
45.43
23%
-53
- C2 -
1XGZ
1
AMYP_HUMAN
A:
[3-449]
-------------------------------------------
S
P
N
T
Q
Q
G
RT
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
A
P
K
G
F
G
G
V
Q
V
S
P
P
N
-----
E
N
V
A
I
Y
N
P
F
R
P
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
D
E
F
R
N
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
N
A
V
----------
S
A
GTSSTCG
S
Y
F
N
PG
S
R
D
F
----
P
-----
A
-------------
V
P
YS---
G
W
D
---
F
NDGKCKT
G
S
-------
G
D
-----
I
E
--
N
Y
-
N
D
A
T
Q
V
R
D
C
R
L
T
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
K
I
A
E
Y
M
N
H
L
I
D
I
G
V
A
G
F
R
L
D
A
S
K
H
M
-
W
P
G
D
I
K
A
I
L
D
K
L
H
N
L
N
S
N
W
F
P
---------
A
-------------
G
------------
S
K
P
F
I
Y
Q
E
V
ID
L
G
G
E
P
I
--
K
S
--
S
D
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
I
R
K
----
W
N
G
E
-
K
M
S
Y
L
K
N
W
G
---
E
---
G
WGF
V
P
S
D
R
A
L
V
F
V
D
S
H
D
N
Q
R
G
H
G
A
G
G
-
A
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
M
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
----------------
P
R
Q
F
Q
--
N
G
NDVNDWVGPPNNNGVIK
E
V
------
T
I
N
P
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
Q
I
R
N
M
V
I
F
R
N
V
V
---
D
G
-
Q
P
F
T
N
W
Y
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
S
F
S
L
T
L
Q
T
G
L
P
A
G
T
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
45.36
23%
-53
- C2 -
1XH1
2
AMYP_HUMAN
A:
[3-449]
-------------------------------------------
S
P
N
T
Q
Q
G
RT
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
A
P
K
G
F
G
G
V
Q
V
S
P
P
N
-----
E
N
V
A
I
Y
N
P
F
R
P
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
D
E
F
R
N
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
N
A
V
----------
S
A
G
TSSTCG
S
Y
F
N
PG
S
R
D
F
----
P
-----
A
-------------
V
P
YS---
G
W
D
---
F
NDGKCKT
G
S
-------
G
D
-----
I
E
--
N
Y
-
N
D
A
T
Q
V
R
D
C
R
L
T
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
K
I
A
E
Y
M
N
H
L
I
D
I
G
V
A
G
F
R
L
D
A
S
K
H
M
-
W
P
G
D
I
K
A
I
L
D
K
L
H
N
L
N
S
N
W
F
P
---------
A
-------------
G
------------
S
K
P
F
I
Y
Q
E
V
ID
L
G
G
E
P
I
--
K
S
--
S
D
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
I
R
K
----
W
N
G
E
-
K
M
S
Y
L
K
N
W
G
---
E
---
G
WGF
V
P
S
D
R
A
L
V
F
V
D
S
H
D
N
Q
R
G
H
G
A
G
G
-
A
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
M
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
----------------
P
R
Q
F
Q
--
N
G
NDVNDWVGPPNNNGVIK
E
V
------
T
I
N
P
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
Q
I
R
N
M
V
I
F
R
N
V
V
---
D
G
-
Q
P
F
T
N
W
Y
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
S
F
S
L
T
L
Q
T
G
L
P
A
G
T
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
45.04
23%
-55
- C2 -
1XH0
1
AMYP_HUMAN
A:
[3-449]
-------------------------------------------
S
P
N
T
Q
Q
G
RT
S
--
I
V
H
L
F
E
W
R
W
V
D
I
A
-
L
E
C
-
E
R
Y
L
A
P
K
G
F
G
G
V
Q
V
S
P
P
N
-----
E
N
V
A
I
Y
N
P
F
R
P
W
W
E
R
Y
Q
P
V
S
Y
K
L
C
T
R
S
-
G
N
E
D
E
F
R
N
M
V
T
R
C
N
N
V
G
V
R
I
Y
V
D
A
V
I
N
H
M
C
-----------
G
N
A
V
----------
S
A
G
TSSTCG
S
Y
F
N
PG
S
R
D
F
----
P
-----
A
-------------
V
P
YS---
G
W
D
---
F
NDGKCKT
G
S
-------
G
D
-----
I
E
--
N
Y
-
N
D
A
T
Q
V
R
D
C
R
L
T
G
L
L
D
L
A
L
E
K
D
Y
V
R
S
K
I
A
E
Y
M
N
H
L
I
D
I
G
V
A
G
F
R
L
D
A
S
K
H
M
-
W
P
G
D
I
K
A
I
L
D
K
L
H
N
L
N
S
N
W
F
P
---------
A
-------------
G
------------
S
K
P
F
I
Y
Q
E
V
ID
L
G
G
E
P
I
--
K
S
--
S
D
Y
F
G
N
G
R
V
T
E
F
K
Y
G
A
K
L
G
T
V
I
R
K
----
W
N
G
E
-
K
M
S
Y
L
K
N
W
G
---
E
---
G
WGF
V
P
S
D
R
A
L
V
F
V
D
S
H
D
N
Q
R
G
H
G
A
G
G
-
A
----
S
---
I
L
T
F
W
D
A
R
L
-
Y
K
-
M
A
V
G
F
M
-
L
-
A
H
P
Y
G
F
T
---------
R
V
M
S
S
Y
R
W
----------------
P
R
Q
F
Q
--
N
G
NDVNDWVGPPNNNGVIKE
V
------
T
I
N
P
--
D
T
T
C
G
--------
N
----
D
-----
W
---
V
C
E
H
R
----
W
----
R
Q
I
R
N
M
V
I
F
R
N
V
V
---
D
G
-
Q
P
F
T
N
W
Y
-
D
-
N
-
G
S
N
Q
V
A
F
G
-
R
G
N
R
G
-
F
I
V
F
N
N
D
D
W
S
F
S
L
T
L
Q
T
G
L
P
A
G
T
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
44.47
21%
-61
- C2 -
1G94
4
AMY_PSEHA
A:
[2-445]
------------------------------------------------
P
T
--
T
--
F
V
H
L
F
E
W
N
W
Q
D
V
A
-
Q
E
C
E
Q
Y
-
L
G
P
K
G
Y
A
A
V
Q
V
S
P
P
N
E
--
H
I
T
G
-------
S
Q
W
W
T
R
Y
Q
P
V
S
Y
-
E
L
Q
S
R
G
G
N
R
A
Q
F
I
D
M
V
N
R
C
S
A
A
G
V
D
I
Y
V
D
T
L
I
N
H
M
A
-----------
A
G
S
G
----------
T
G
-------------
T
A
G
N
SFGN
K
-----
S
-------------
F
P
IYSPQ
D
F
H
---
E
--------
S
-------
C
T
-----
I
N
N
S
D
Y
G
N
D
R
Y
R
V
Q
N
C
E
L
V
G
L
A
D
L
D
T
A
S
N
Y
V
Q
N
T
I
A
A
Y
I
N
D
L
Q
A
I
G
V
K
G
F
R
F
D
A
S
K
H
V
A
A
----------------
S
D
I
Q
S
L
------
M
A
-------------
K
VN----------
G
S
P
V
V
F
Q
E
V
--
I
D
Q
G
G
E
AV
G
A
--
S
E
Y
L
S
T
G
L
V
T
E
F
K
Y
S
T
E
L
G
N
T
F
R
N
----
G
S
-
L
---
A
W
L
S
N
F
G
EGW
G
---
F
---
M
P
S
S
S
A
V
V
F
V
D
N
H
D
N
-
Q
R
G
H
G
G
A
-
G
----
N
VIT
F
E
D
G
R
L
Y
D
L
A
N
V
-
F
M
L
A
Y
P
Y
G
-
Y
P
K
V
M
S
S
---------------------------------
Y
D
F
H
G
--
D
T
------------------
D
------
A
G
G
P
--
N
V
P
V
H
--------
N
----
N
GNLEC
F
---
A
S
N
W
K
----
C
EHRW
S
Y
I
A
G
G
V
D
F
R
N
N
T
ADN
W
A
-
V
T
N
W
W
D
N
-
T
-
N
-
N
Q
I
S
F
G
R
G
---
S
S
G
-
H
M
A
I
N
K
E
D
S
T
L
T
A
T
V
Q
T
D
M
A
S
G
Q
Y
C
N
V
L
K
G
---------
E
---------
L
S
ADAKSCS
G
E
V
I
T
V
N
S
D
G
T
I
N
-
L
N
I
G
A
---
W
---
D
A
M
A
I
H
K
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
44.12
24%
-58
- C2 -
1CLV
2
AMY_TENMO
A:
[12-444]
----------------------------------------------------
S
--
I
V
H
L
F
E
W
K
W
N
D
I
A
-
D
E
C
-
E
R
F
L
Q
P
Q
G
F
G
G
V
Q
I
S
P
P
N
E
YL
V
A
D
G
R
P
-------
W
W
E
R
Y
Q
P
V
S
Y
I
I
N
T
R
S
-
G
D
E
S
A
F
T
D
M
T
R
R
C
N
D
A
G
V
R
I
Y
V
D
A
V
I
N
H
M
T
G
M
N
G
V
G
TSG
S
S
A
D
H
D
----------
G
M
-------------
N
--
Y
----
P
-----
A
-------------
V
P
-----
Y
G
S
GDF
H
-------
S
P
-------
C
E
-----
V
N
--
N
Y
-
Q
D
A
D
N
V
R
N
C
E
L
V
G
L
R
D
L
N
Q
G
S
D
Y
V
R
G
V
L
I
D
Y
M
N
H
M
I
D
L
G
V
A
G
F
R
V
D
A
A
K
H
M
S
-
P
G
D
--------
L
S
V
I
F
S
G
L
K
N
L
NTDYGF
A
D
-------------
G
------------
A
R
P
F
I
Y
Q
E
V
ID
L
G
G
E
A
I
--
S
K
--
N
E
Y
T
G
F
G
C
V
L
E
F
Q
F
G
V
S
L
G
N
A
F
Q
G
----
G
N
-
Q
--
L
K
N
L
A
N
W
G
---
P
---
E
WGL
L
E
G
L
D
A
V
V
F
V
D
N
H
D
N
-
Q
R
T
G
G
S
Q
-
I
L---
T
---
Y
K
N
P
K
P
Y
K
M
A
I
A
F
M
L
A
H
P
Y
-
G
-
T
T
R
I
M
S
S
F
D
FTDNDQG
P
-----------------------
P
Q
D
G
S
--
G
N
------------------
L
------
I
S
P
G
--
I
N
D
D
N
--------
T
----
C
-----
S
---
N
G
Y
V
C
----
E
HRW-
R
Q
V
Y
G
M
V
G
F
R
N
A
V
---
E
G
-
T
Q
V
E
N
W
W
-
S
-
N
-
D
D
N
Q
I
A
F
S
-
R
G
S
Q
G
F
V
A
F
T
N
G
G
D
L
N
Q
N
L
N
T
G
--
L
P
A
G
T
Y
-------------------------------------
C
D
V
-
I
S
G
E
L
S
G
G
S
C
T
G
---
K
---
S
V
T
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------