@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03110: (2016-06-05 )
MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGFSVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEMLITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTAAIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVMGLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGYNLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPALGLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQIYLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP
Atome Classification :
(20 SA)
........-----.10........20........30.----....--------------------...40.---.......50--..--------...-...60...-.....70--.-...-....80......----...-90...--------------.....100....---...110.....----..120------.--..-----...---.---..130.......140-----------.--.......------------------150.------......160.......170.......--180.......190--.....-....200....--...---------210.---......220.......230--....-..-.-.240----.........250.....---..260.-.-.---....270....------..--.280.......--290....-----------...300.......----310......----.320..------.....330---.......340....-..--------.350.--.-------------------..---....360.........370-------........380....---------...390.......400..-.....410---...-----------.-------------...420.......----430.......440....---------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQTKKDQ-----PKG
N
L
A
W
W
Q
L
S
L
I
G
V
G
C
TIG
T
G
F
F----LGS
S
--------------------
I
A
I
V
K
S
---
G
F
S
V
L
L
S
F
L
--
I
A
--------
G
I
G
-
T
Y
F
V
F
E
Q
L
-
A
K
L
SAKQ--P-EKG-
S
F
C
A
Y
-
A
R
K
A
F
G
----KWA-GFSN
G
--------------
W
V
Y
W
TS
E
M
L
I
TG---S
Q
L
T
A
I
S
L
F
T
K
----HWF--------P--QV-----
P
L
W
---
V
---
F
A
S
I
Y
A
V
L
G
L
L
I
I
F
------------
T
--
G
L
S
V
F
E
K
------------------
T
E
N
V
------
L
A
V
I
K
T
A
A
I
F
M
F
I
V
I
A
I
L
A
L
C
G
I
LSG--GNH
G
I
HVPNKT----SEFFP-YG
A
M
G
L
W
T
G
L
I
--
Y
A
F
---------
Y
A
FG---GI
E
V
M
G
L
M
A
V
HLKK
P
E
EA---SKSG-K
L
-
M
-
L
A
------
T
L
A
I
I
Y
I
I
S
I
G
L
A
L
L
L
V
---PLHTFT-E-Q---DSP
F
I
T
SLKGY------
N
L
--
E
I
I
L
D
IFN
G
I
F
--
I
IA
G
F
S
T
-----------
L
V
A
S
L
F
A
V
T
T
L
L
C
----TMADDGDAP----
K
C
F
T
LK------EG
K
K
I
C
W
P
---
A
L
G
L
T
F
A
G
L
V
L
S
I
I
-
L
S
--------
L
V-L
P
--
K
-------------------
N
I
---
Y
E
H
M
T
--
T
A
A
G
L
M
L
L
Y
T
W
--------
L
F
I
L
FSSKKLTDPEG---------MG
K
T
Q
I
Y
L
A
M
V
L
I
A
A
A
VS-G
T
L
FEKSS---RP
G
-----------
F
-------------
F
V
S
I
G
F
L
V
I
I
A
I
V
----
T
M
I
Y
Q
KKQGHKDRPASP---------------------------
1
PsiBlast_PDB
88.34
22%
-165
- C4 -
3GI8
-
Y609_METJA
C:
[8-375]
-----------------
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
SIFG
V
G
A
K
--------------------
I
A
-------
G
R
N
L
P
E
T
F
I
--
L
S
--------
G
I
Y
-
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
--
V
-
S
N
A
-
G
P
I
A
F
-
I
H
K
A
I
G
-----------
D
N
--------------
I
I
T
G
A
L
S
I
L
L
W
M
---
S
Y
V
I
S
I
A
L
F
A
K
GFAG
Y
F
L
--------
P
LI
N
A
-----
P
I
N
---
T
---
F
N
I
A
I
T
E
I
G
I
V
A
F
F
------------
T
--
A
L
N
F
F
G
S
------------------
K
----------
A
V
G
R
--
A
E
F
F
I
V
L
V
A
L
L
I
L
G
L
F
I
F
A
--
G
L
I
T
I
H
P
S
Y
V
I
----
P
D
L
A
P
-
S
A
V
S
G
M
I
F
A
S
A
--
I
F
F
---------
L
S
Y
M
---
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
-----
N
V
P
-
R
A
-
I
-
F
I
------
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
GNL
P
I
D
E
L
I
-
K
A
S
---
E
N
A
L
A
V
A
A
K
P
F
LG----
N
L
--
G
F
L
L
I
S
I
G
A
L
F
--
S
I
S
--
S
A
-----------
M
N
A
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
K
D
G
E
L
P
----
E
F
F
E
R
K
VWFKST
E
G
L
Y
I
T
-
S
---
A
L
G
V
L
F
A
-
L
L
F
N
M
---------------------------------------------
E
G
V
A
--
S
I
T
S
A
V
F
M
V
I
Y
--------
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
----------
G
R
K
E
I
-----------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.25
22%
-165
- C4 -
3GIA
6
Y609_METJA
A:
[8-375]
-----------------
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
SI
F
G
V
G
A
K
--------------------
I
A
-------
G
R
N
L
P
E
T
F
I
--
L
S
--------
G
I
Y
-
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
--
V
-
S
N
A
-
G
P
I
A
F
-
I
H
K
A
I
G
-----------
D
N
--------------
I
I
T
G
A
L
S
I
L
L
W
M
---
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
--------
P
L
I
N
A
-----
P
I
N
---
T
---
F
N
I
A
I
T
E
I
G
I
V
A
F
F
------------
T
--
A
L
N
F
F
G
S
------------------
K
----------
A
V
G
R
--
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
--
G
L
I
T
I
H
P
S
Y
V
I
----
P
D
L
A
P
-
S
A
V
S
G
M
I
F
A
S
A
--
I
F
F
---------
L
S
Y
M
---
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
-----
N
V
P
-
R
A
-
I
-
F
I
------
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
E
L
I
-
K
A
S
---
E
N
A
L
A
V
A
A
K
P
F
LG----
N
L
--
G
F
L
L
I
S
I
G
A
L
F
--
S
I
S
--
S
A
-----------
M
N
A
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
K
D
G
E
L
P
----
E
F
F
E
R
K
VWFKS
T
E
G
L
Y
I
T
-
S
---
A
L
G
V
L
F
A
-
L
L
F
N
M
---------------------------------------------
E
G
V
A
--
S
I
T
S
A
V
F
M
V
I
Y
--------
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
----------
G
R
K
E
I
-----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.88
22%
-166
- C4 -
3GI9
-
Y609_METJA
C:
[8-375]
-----------------
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
SI
F
G
V
G
A
K
--------------------
I
A
-------
G
R
N
L
P
E
T
F
I
--
L
S
--------
G
I
Y
-
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
--
V
-
S
N
A
-
G
P
I
A
F
-
I
H
K
A
I
G
-----------
D
N
--------------
I
I
T
G
A
L
S
I
L
L
W
M
---
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
--------
P
L
I-
A
-----
P
I
N
---
T
---
F
N
I
A
I
T
E
I
G
I
V
A
F
F
------------
T
--
A
L
N
F
F
G
S
------------------
K
----------
A
V
G
R
--
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
--
G
L
I
T
I
H
P
S
Y
V
I
----
P
D
L
A
P
-
S
A
V
S
G
M
I
F
A
S
A
--
I
F
F
---------
L
S
Y
M
---
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
-----
N
V
P
-
R
A
-
I
-
F
I
------
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
E
L
I
-
K
A
S
---
E
N
A
L
A
V
A
A
K
P
F
LG----
N
L
--
G
F
L
L
I
S
I
G
A
L
F
--
S
I
S
--
S
A
-----------
M
N
A
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
K
D
G
E
L
P
----
E
F
F
E
R
K
VWFKS
T
E
G
L
Y
I
T
-
S
---
A
L
G
V
L
F
A
-
L
L
F
N
M
---------------------------------------------
E
G
V
A
--
S
I
T
S
A
V
F
M
V
I
Y
--------
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
----------
G
R
K
E
I
-----------------------------------------------------------------------------------------------------------------
14
HHSearch
83.16
17%
-153
- C4 -
3L1L
2
ADIC_ECO57
A:
[7-378]
--------------
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
----
L
L
P
A
--------------------
N
L
A
S
-
T
---
G
G
I
A
I
Y
G
W
L
--
V
T
--------
I
I
G
-
A
L
G
L
S
M
V
Y
-
A
K
M
S
F
L
D
--
P
-
S
P
G
-
G
S
Y
A
Y
-
A
R
R
C
F
G
----
P
F
L
-
G
Y
Q
T
N
--------------
V
L
Y
W
L
A
C
W
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
--------
P
--
I
L
K----
D
P
W
---
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
------------
V
--
G
P
K
M
I
T
R
------------------
V
Q
A
V
------
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
------
F
--
R
G
E
T
Y
M
-
A
-----------------
A
I
Q
S
T
L
N
--
V
T
L
---------
W
S
F
I
---
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
---
V
P
I
A
-
T
I
G
G
-
V
L
------
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
---
P
N
A
A
L
R
-
V
-
S
---
A
S
P
F
G
D
A
A
R
M
A
------
L
G
--
D
T
A
G
A
I
V
S
F
C
A
--
A
A
G
C
L
G
S
-----------
L
G
G
W
T
L
L
A
G
Q
T
A
K
----
A
A
A
D
D
G
L
F
P
----
P
I
F
A
R
V
------
N
K
A
G
T
P
V
A
---
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
-
S
S
---------
I
-
S
P
NA
T
-------------------
K
E
---
F
G
L
V
S
--
S
V
S
V
I
F
T
L
V
P
Y
--------
L
Y
T
C
A
A
L
L
L
L
G
H
G
----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.29
23%
-161
- C4 -
3L1L
2
ADIC_ECO57
A:
[15-349]
----------------------
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
----
L
L
P
A
---------------------
N
L
A
S
T
---
G
G
I
A
I
Y
G
W
L
--
V
T
--------
I
I
G
-
A
L
G
L
S
M
V
Y
-
A
K
M
S
F
L
D
--
P
-
S
P
G
-
G
S
Y
A
Y
-
A
R
R
C
F
G
----
P
F
L
-
G
Y
Q
T
N
--------------
V
L
Y
W
L
A
C
W
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
--------
P
IL
K
D
-----
P
-
W
---
V
---
L
T
I
T
C
V
V
--
V
L
W
I
F
------------
V
--
L
L
N
I
V
G
P
-------------------
K
M
I
------
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
--
R
G
E
T
Y
M
A
----------------
A
I
Q
--
S
T
L
N
--
V
T
L
---------
W
S
F
I
---
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
-
G
V
-
L
-
I
A
--------
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
---
P
N
A
A
L
R
-
V
-
S
---
A
S
P
F
G
D
A
A
R
------------
M
A
L
G
D
T
A
G
A
I
V
--
S
F
C
A
A
A
G
-----------
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
----
P
I
F
--
A
------
R
V
N
K
A
G
T
P
---
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
--------
S
I
-
S
P
--
N
-------------------
A
T
---
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.94
22%
-152
- C4 -
3LRB
-
ADIC_ECO57
A:
[15-349]
----------------------
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
----
L
L
P
A
---------------------
N
L
A
S
T
---
G
G
I
A
I
Y
G
W
L
--
V
T
--------
I
I
G
-
A
L
G
L
S
M
V
Y
-
A
K
M
S
F
L
D
--
P
-
S
P
G
-
G
S
Y
A
Y
-
A
R
R
C
F
G
----
P
F
L
-
G
Y
Q
T
N
--------------
V
L
Y
W
L
A
C
W
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
--------
P
--
I
L
-----
K
D
P
---
L
---
V
L
T
I
T
C
V
V
-
V
L
W
I
F
------------
V
--
L
L
N
I
V
G
P
-------------------
K
M
I
------
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
--
R
G
E
T
Y
M
A
A
W
N
V
----
S
G
L
G
T
-
F
G
A
--
I
Q
S
T
L
N
--
V
T
L
---------
W
S
F
I
---
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
-
G
V
-
L
-
I
A
--------
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
---
P
N
-------------------------------------
T
A
G
A
I
V
--
S
F
C
A
A
A
G
-----------
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
----
P
I
F
--
A
------
R
V
N
K
A
G
T
P
---
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
--------
S
I
-
S
P
--
N
-------------------
A
T
---
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.90
20%
-147
- C4 -
3NCY
-
ADIC_SALTY
A:
[15-372]
----------------------
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
----
L
L
P
A
---------------------
N
L
A
A
T
---
G
G
I
A
I
Y
G
W
L
--
V
T
--------
I
I
G
-
A
L
A
L
S
M
V
Y
-
A
K
M
S
S
L
D
--
P
-
S
P
G
-
G
S
Y
A
Y
-
A
R
R
C
F
G
----
P
F
L
-
G
Y
Q
T
N
--------------
V
L
Y
W
L
A
C
W
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
--------
P
IL
K
D
-----
P
L
V
---
L
---
T
L
T
C
V
A
V
L
W
I
F
V
L
L
------------
N
I
V
G
P
K
M
I
T
R
------------------
V
Q
A
V
------------
A
T
V
L
A
L
V
P
I
V
G
I
A
V
F
G
W
F
W
F
--
K
G
E
-----
W
N
V
----
S
G
M
N
T
-
F
G
A
--
I
Q
S
T
L
N
--
V
T
L
---------
W
S
F
I
---
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
-
G
V
-
L
-
I
A
--------
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
---
P
N
A
A
L
R
-
V
-
S
---
A
S
P
F
G
D
A
A
R
------------
M
A
L
G
D
T
A
G
A
I
V
--
S
F
C
A
A
A
G
-----------
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
----
P
I
F
--
A
------
R
-----
T
P
---
V
A
G
L
L
I
V
G
V
L
M
T
I
F
-
Q
F
--------
S
S
-
M
S
--
P
-------------------
N
A
---
A
K
E
F
G
--
L
V
S
S
V
S
V
I
F
T
L
--------
V
P
Y
L
Y
T
C
A
A
L
-------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.75
22%
-149
- C4 -
3LRC
-
ADIC_ECO57
A:
[15-349]
----------------------
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
----
L
L
P
A
---------------------
N
L
A
S
T
---
G
G
I
A
I
Y
G
W
L
--
V
T
--------
I
I
G
-
A
L
G
L
S
M
V
Y
-
A
K
M
S
F
L
D
--
P
-
S
P
G
-
G
S
Y
A
Y
-
A
R
R
C
F
G
----
P
F
L
-
G
Y
Q
T
N
--------------
V
L
Y
W
L
A
C
W
I
G
N
I
---
A
M
V
V
I
G
V
G
Y
L
S
----
Y
F
F
--------
P
--
I
L
-----
K
D
P
---
L
---
V
L
T
I
T
C
V
V
-
V
L
W
I
F
------------
V
--
L
L
N
I
V
G
P
-------------------
K
M
I
------
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
--
R
G
E
T
Y
M
A
A
W
N
V
----
S
G
L
G
T
-
F
G
A
--
I
Q
S
T
L
N
--
V
T
L
---------
W
S
F
I
---
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
-
G
V
-
L
-
I
A
--------
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
---
P
N
-------------------------------------
T
A
G
A
I
V
--
S
F
C
A
A
A
G
-----------
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
TAK
A
A
A
D
D
G
L
F
P
----
P
I
F
--
A
------
R
V
N
K
A
G
T
P
---
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
--------
S
I
-
S
P
--
N
-------------------
A
T
---
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
76.88
16%
-148
- C4 -
3GIA
6
Y609_METJA
A:
[3-369]
-------
L
-----
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
----
S
I
F
G
--------------------
V
G
A
K
I
A
---
G
R
N
L
P
E
T
F
I
--
L
S
--------
G
I
Y
-
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
--
V
-
S
N
A
-
G
P
I
A
F
-
I
H
K
A
I
G
----
D
N
I
I
T
G
A
L
S
--------------
I
L
L
W
M
S
Y
V
I
S
I
A
---
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
--------
N
--
A
P
I----
N
T
F
N
I
A
I
---
T
E
I
G
I
V
A
F
F
T
A
L
N
F
------------
F
--
G
S
K
A
V
G
R
------------------
A
E
F
F
------
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
------
I
-------
H
P
S
Y
V
I
----
P
D
L
A
P
-
S
A
V
S
G
M
I
F
A
S
A
--
I
F
F
---------
L
S
Y
M
---
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
---
V
P
R
A
-
I
F
I
S
-
I
L
------
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
---
P
I
D
E
L
I
K
A
-
S
---
E
N
A
L
A
V
A
A
K
P
F
------
L
G
--
N
L
G
F
L
L
I
S
I
G
A
--
L
F
S
I
S
S
A
-----------
M
N
A
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
K
D
G
E
L
P
----
E
F
F
E
R
K
------
V
W
F
K
S
T
-
E
---
G
L
Y
I
T
S
A
L
G
---
V
L
-
F
A
--------
L
L
-
F
------------------------
N
---
M
E
G
V
A
--
S
I
T
S
A
V
F
M
V
I
Y
--------
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
---------------------------------------------------------------------------------------------------------------------------------
25
Fugue
76.62
14%
-151
- C4 -
3GIA
7
Y609_METJA
A:
[3-435]
-------
L
-----
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
----
S
I
F
G
--------------------
V
G
A
K
I
A
---
G
R
N
L
P
E
T
F
I
--
L
S
--------
G
I
Y
-
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
--
V
-
S
N
A
-
G
P
I
A
F
-
I
H
K
A
I
G
D---
N
I
I
-
T
G
A
L
S
--------------
I
L
L
W
M
S
Y
V
I
S
I
A
---
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
NAP-----
I
--
N
T
-----
F
N
I
---
A
---
I
T
E
I
G
I
V
A
F
F
T
A
L
N
------------
F
F-
G
S
K
A
V
G
R
------------------
A
E
F
F
------
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
-------------
I
H
P
S
Y
V
I
----
P
D
L
A
P
-
S
A
V
S
G
M
I
F
A
S
A
--
I
F
F
---------
L
S
Y
M
---
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
---
V
P
R
A
I
F
I
-
S
-
I
L
------
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
---
P
I
D
E
L
I
-
K
A
S
---
E
N
A
L
A
V
A
A
K
P
F
------
L
G
--
N
L
G
F
L
L
I
S
I
G
A
--
L
F
S
I
S
S
A
-----------
M
N
A
T
I
Y
G
G
A
N
V
A
Y
----
S
L
A
K
D
G
E
L
P
----
E
F
F
E
R
K
------
V
W
F
---
K
S
---
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
-
A
L
--------
L
F
-
N
M
--
E
-------------------
G
V
---
A
S
I
T
S
--
A
V
F
M
V
I
Y
L
F
V
I
--------
L
S
H
Y
I
L
I
D
E
V
G
G
R
------------
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
-
L
L
Y
Y
Q
W
I
T
---
N
R
F
-----------
V
-------------
F
Y
G
I
I
A
T
F
I
G
V
L
I
----
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
YVKS-----------------------
31
Fugue
74.47
19%
-159
- C4 -
4US3
13
?
A:
[10-450]
-
G
R
E
Q
W
A
S
-----
R
L
G
F
I
L
A
A
M
G
S
A
V
G
L
G
N
I
W
R
F
S
Y
V
----
T
G
E
-------------------------
N
G
---
G
A
A
F
L
L
V
Y
L
G
F
I
A
--------
L
I
G
-
I
P
I
V
L
A
E
F
-
T
I
G
R
R
A
Q
--
S
---
D
-
A
V
G
S
F
-
E
K
L
A
P
G
K---
P
W
K
-
V
A
G
L
M
--------------
G
V
A
A
G
F
L
I
L
S
F
Y
---
G
V
I
A
G
W
I
L
F
Y
L
----
F
N
Y
--------
I
--
T
G
-----
Q
L
W
---
S
---
A
P
A
----
E
G
F
G
G
F
F
------------
E
--
G
F
I
A
-----------------------
N
P
------
T
L
P
L
F
W
Q
A
L
F
M
I
A
T
I
W
I
V
A
I
-----
G
--
V
K
K
G
I
E
R
S
N
K
I
------------
L
M
P
L
L
G
V
L
L
--
I
A
L
---------
A
I
Y
S
L
T
L
G
G
A
K
E
G
L
A
F
L
F
S
P
D
W
S
A
L
---
K
D
P
G
-
V
Y
-
L
-
A
A
------
I
S
Q
A
F
F
T
L
S
L
G
M
G
A
L
I
T
---
Y
G
-
S
Y
V
-
S
-
K
---
D
S
R
-----------------------
L
P
G
A
A
V
--
S
V
A
G
L
D
T
-----------
A
F
A
I
I
A
G
I
M
I
F
P
A
----
V
F
A
L
G
L
S
P
S
----
G
------------
G
P
G
L
V
F
V
---
V
L
P
D
I
F
D
S
I
R
L
G
P
I
-
V
G
--------
I
A
-
F
F
--
I
-------------------
L
L
---
G
A
A
A
L
--
S
S
A
-
V
S
L
L
E
V
P
--------
V
A
Y
F
M
R
K
F
D
W
S
R
K
Q
A
---------
A
I
T
L
G
V
I
I
T
L
L
G
I
P
S
S
L
S
F
G
V
L
G
E
V
T
I
---
I
P
G
-----------
L
N
I
F
D
S
V
D
F
I
A
SSV
F
L
P
L
G
G
M
I
I
A
L
F
I
----
G
W
G
W
K
T
S
D
A
L
A
E
S
D
L
T
D
S
V
W
G
K
L
W
I
L
S
L
R
F
I
A
P
I
A
I
L
I
V
F
L
S
A
F
27
Fugue
71.50
12%
-168
- C4 -
4DJK
-
GADC_ECOLI
A:
[12-501]
----------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
--------
V
Y
E
Y
--------------------
P
T
F
A
T
S
---
G
F
S
L
V
F
F
L
L
--
L
G
--------
G
I
L
----
W
F
I
P
V
-
G
L
C
A
A
E
M
A
T
V
-
D
G
W
-
G
V
F
A
W
-
V
S
N
T
L
G
----
P
R
W
-
G
F
A
A
I
--------------
S
F
G
Y
L
Q
I
A
I
G
F
I
---
P
M
L
Y
F
V
L
G
A
L
S
----
Y
I
L
--------
K
--
W
P
-----
A
L
----
N
---
E
D
P
I
T
K
T
I
A
A
L
I
I
L
------------
W
--
A
L
A
L
T
Q
F
------------------
G
G
T
K
------
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
--
I
Y
L
H
T
F
F
P
D
F
S
----
K
--------
V
G
T
L
V
V
F
V
--
A
F
I
---------
L
S
Y
M
---
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
---
Y
P
L
A
-
M
L
-
L
-
L
M
------
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
---
I
P
G
N
E
I
-
N
-
L
---
S
A
G
V
M
Q
T
F
T
V
L
M
SHVAP
E
I
--
E
W
T
V
R
V
I
S
A
L
L
--
L
L
G
V
L
A
E
-----------
I
A
S
W
I
V
G
P
S
R
G
M
Y
----
V
T
A
Q
K
N
L
L
P
----
A
A
F
A
K
M
------
N
K
N
G
V
P
V
T
---
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
-
I
L
--------
T
N
-
T
G
--
G
-------------------
G
N
N
M
S
F
L
I
A
L
--
A
L
T
V
V
I
Y
L
C
A
Y
--------
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
DLKRT
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
-
M
A
F
I
V
S
F
L
---
P
P
D
NIQGDSTDMY
V
E
-------------
L
L
V
V
S
F
L
V
V
L
A
L
P
----
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
---------------------------
33
Fugue
63.64
11%
-156
- C4 -
2JLN
2
?
A:
[8-470]
E
A
R
S
L
L
N
P
SNAPT
R
Y
A
E
R
S
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
----
I
F
I
A
--------------------
A
G
Q
M
T
S
---
S
F
Q
V
W
Q
V
I
V
--
A
I
--------
A
A
G
-
C
T
I
A
V
I
L
L
-
F
F
T
Q
S
A
A
--
I
-
R
W
G
I
N
F
T
V
A
-
A
R
M
P
F
G
IRGS
L
I
P
-
I
T
L
K
A
--------------
L
L
S
L
F
W
F
G
F
Q
T
W
---
L
G
A
L
A
L
D
E
I
T
R
----
L
L
T
--------
G
--
F
T
-----
N
L
P
---
L
---
W
I
V
I
F
G
A
I
Q
V
V
T
T
F
------------
Y
--
G
------------------------
I
T
F
I
------
R
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
--
D
V
S
L
G
E
V
M
S
M
G
----
G
E
N
P
G
-
M
P
F
S
T
A
I
M
I
F
V
G
G
W
I
A
---------
V
V
V
S
---
I
H
D
I
V
K
E
C
K
V
D
P
N
A
S
R
E
G
---
Q
T
K
A
-
D
A
-
R
-
Y
A
------
T
A
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
---
G
A
A
S
M
V
-
L
-
V
---
G
E
W
N
P
V
I
A
I
T
E
------
V
V
--
G
G
V
S
I
P
M
A
I
L
F
--
Q
V
F
V
L
L
A
-----------
T
W
S
T
N
P
A
A
N
L
L
S
P
----
A
Y
T
L
C
S
T
F
P
----
R
V
F
T
F
K
------
T
G
V
I
V
S
A
V
---
V
G
L
L
M
M
P
W
Q
F
A
G
V
L
-
N
T
--------
F
L
-
N
L
--
L
-------------------
A
S
---
A
--
L
G
--
P
L
A
G
I
M
I
S
D
Y
F
LVRRRRIS
L
H
D
L
Y
R
T
K
G
I
Y
T
Y
W
R
----------
G
V
N
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
-
F
L
T
P
D
L
M
F
---
V
T
G
-----------
L
-------------
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
R
P
IG-------------------------
15
HHSearch
63.26
12%
-179
* C4 *
4DJK
-
GADC_ECOLI
A:
[12-418]
----------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
--
A
V
Y
----
E
Y
P
----------------------
T
F
A
T
S
---
G
F
S
L
V
F
F
L
L
--
L
G
--------
G
I
L
W
F
I
P
V
G
L
C
A
-
A
E
M
A
T
V
D
--
G
W----
G
V
F
A
W
-
V
S
N
T
L
G
----
P
R
W
-
G
F
A
A
I
--------------
S
F
G
Y
L
Q
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
----
K
W
---------
P
--
A
L
NEDP
I
T
K
T
---
I
---
A
A
L
I
I
L
W
A
L
A
L
T
Q
F
------------
G
--
G
T
K
Y
T
A
R
------------------
I
A
K
V
------
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
---
H
-------------------
T
F
F
P
D
F
S
K
V
G
T
L
V
V
F
V
--
A
F
I
---------
L
S
Y
M
---
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
---
Y
P
L
A
-
M
L
-
L
L
M
V
------
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
I
---
P
G
N
E
I
N
-
L
-
S
A
G
V
M
Q
T
F
T
V
L
M
S
H
V
------
A
P
EI
E
W
T
V
R
V
I
S
A
L
L
--
L
L
G
V
L
A
E
-----------
I
A
S
W
I
V
G
P
S
R
G
M
Y
----
V
T
A
Q
K
N
L
L
P
----
A
A
F
A
K
M
------
N
K
N
G
V
P
V
T
---
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
-
I
L
--------
T
N
T
G
G
--
G
-------------------
N
N
---
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
--------
F
M
L
F
I
G
Y
I
V
L
V
L
-----------------------------------------------------------------------------------------------------------------------------------
32
Fugue
60.07
12%
-176
* C3 *
1EHK
6
COX1_THET8
A:
[14-562]
A
Y
P
E
K
K
A
T
-----
L
Y
F
L
V
L
G
F
L
A
L
I
V
G
S
L
F
G
P
F
Q
A
L
N
----
Y
G
N
V
DA
Y
P
L
L
K
R
L
L
PFVQS
Y
Y
Q
G
L
T
L
H
G
V
L
---
N
A
I
V
F
T
Q
L
F
--
A
Q
--------
A
I
M
-
V
Y
L
P
A
R
E
L
N
M
R
P
N
M
G
L
--
M
-
W
L
S
-
W
W
M
A
F
-
I
G
L
V
V
A
----
A
L
P
-
L
L
A
N
E
ATVLYTFYPPLKGH
W
A
F
Y
L
G
A
S
V
F
V
L
---
S
T
W
V
S
I
Y
I
V
L
D
----
L
W
R
R
W
K
A
A
N
PG
K
--
V
T
-----
P
L
V
---
T
---
Y
M
A
V
V
F
W
L
M
W
F
L
A
S
------------
L
--
G
L
V
L
E
A
V
L
F
L
L
P
W
S
F
GLVEGVD
P
L
V
A
R
T
L
------
F
W
W
T
G
H
P
I
V
Y
F
W
L
L
P
A
Y
A
I
I
Y
T
I
L
P
K
Q
A
G
G
K
L
V
S
D
P
M
A
R
----
L
A
F
L
L
-
F
L
L
L
S
T
P
V
G
F
H
--
H
Q
F
ADPGID
P
T
W
K
M
I
H
---
S
V
L
T
L
F
V
A
V
P
S
L
M
T
A
F
T
V
---
A
A
S
L
-
E
F
-
A
-
G
R
L
R
GGRG
L
F
G
W
I
R
A
L
P
W
D
N
P
A
F
V
A
---
P
V
L
G
L
L
-
G
-
F
---
I
P
G
G
A
G
G
I
V
N
A
------
S
F
--
T
L
D
Y
V
V
H
N
T
A
W
--
V
P
G
H
F
H
L
-----------
Q
V
A
S
L
V
T
L
T
A
M
G
S
----
L
Y
W
L
L
P
N
L
T
----
G
K
P
I
S
D
------
A
Q
R
R
L
G
L
A
---
V
V
W
L
W
F
L
G
M
M
I
M
A
V
-
G
L
--------
H
W
-
A
G
--
L
L
NVPRRAYIAQVPDAYPHA
A
V
---
P
M
V
F
N
--
V
L
A
G
I
V
L
L
V
A
L
--------
L
L
F
I
Y
G
L
F
S
V
L
L
S
R
----------
L
A
E
A
P
L
P
F
A
E
V
I
S
G
P
E
D
R
-
R
L
V
L
A
M
D
R
---
I
G
F
-----------
W
-------------
F
A
V
A
A
I
L
V
V
L
A
Y
G
----
P
T
L
V
Q
L
F
G
H
L
N
P
V
P
G
W
R
LW-------------------------
28
Fugue
59.42
17%
-162
- C3 -
4IKW
20
?
A:
[3-494]
--
S
I
D
K
Q
Q
-----
I
A
A
S
V
P
--
Q
R
G
F
F
G
H
P
K
G
L
F
T
L
F
F
----
T
E
F
W
--------------------
E
R
F
S
Y
Y
---
G
M
R
A
I
L
V
Y
Y
--
M
Y
YEVSKGGL
G
L
D
-
E
H
L
A
L
A
I
M
-
S
I
Y
G
A
L
V
--
Y
-
M
S
G
-
I
I
G
G
W
L
A
D
R
V
F
G
----------
T
S
R
--------------
A
V
F
Y
G
G
L
L
I
M
A
G
---
H
I
A
L
A
I
P
G
G
V
A
----
A
L
F
--------
V
--
S
M
-----
A
L
I
---
V
---
L
G
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
KPGDDR
R
D
A
--
G
F
S
I
F
Y
M
------------------
G
I
N
L
G
A
F
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
--
L
V
V
F
V
A
T
R
K
K
N
LGLA
G
T
Y
V
P
-
N
P
L
T
P
A
E
K
K
K
A
--
A
A
I
---------
M
A
V
G
---
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
F
T
---
V
E
T
F
-
I
S
-
L
-
V
G
------
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
R
S
---
P
-
K
T
T
A
-
E
-
E
---
R
S
R
V
I
A
Y
I
P
L
F
------
V
A
--
S
A
M
F
W
A
I
Q
E
Q
G
ST
I
L
A
N
Y
A
D
KRTQLDVAG
I
H
L
S
P
A
W
F
Q
S
L
N
P
L
F
----
I
I
I
L
A
P
V
F
A
----
W
M
W
V
K
L
------
G
K
R
Q
P
T
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
F
I
V
I
-
L
V
P
G
H
L
S
GGG
L
V
-
H
P
--
I
-------------------
W
L
---
V
L
S
Y
F
--
I
V
V
L
G
E
L
C
L
S
P
--------
V
G
L
S
A
T
T
K
L
A
P
A
A
F
S
---------
A
Q
T
M
S
L
W
F
L
S
N
A
A
A
Q
A
I
N
-
A
Q
L
V
R
F
Y
T
PEN
E
T
A
-----------
Y
-------------
F
G
T
I
G
G
A
A
L
V
L
G
L
----
I
L
L
A
I
A
P
R
I
G
R
L
M
K
G
-----------------------------
29
Fugue
52.89
15%
-151
- C2 -
3VH3
1
ATG7_YEAST
A:
[4-323]
M
L
K
I
A
D
Q
S
-----
V
D
L
N
L
K
L
M
K
W
R
I
L
P
---
D
L
N
L
D
I
I
----
K
N
T
K
--------------------
V
L
L
L
G
A
G
T
L
G
C
Y
V
S
R
A
L
I
--
A
W
--------
G
V
R
-
K
I
T
F
V
D
N
--
G
T
V
S
Y
S
N
--
P
-
V
R
Q
-
A
L
Y
N
F
-
E
D
C
G
K
P
----
K
A
E
-
L
A
A
A
S
--------------
L
K
R
I
F
P
L
M
D
A
T
G
---
V
K
L
S
-----------------------------------------------------
I
P
M
------------
I
--
G
H
K
L
V
N
E
------------------
E
A
Q
H
------
K
D
F
D
R
L
R
A
L
I
K
E
H
D
I
I
F
L
L
V
---------------
D
S
R
E
----
S
R
W
L
P
-
S
L
L
S
N
I
-----------------------------------------------------------------
E
N
K
T
V
I
N
A
A
L
G
F
D
S
Y
L
V
---
M
R
H
G
N
R
-
D
-
E
---
Q
S
S
---------------------------------------------------------
K
Q
L
G
C
----
Y
F
C
H
D
V
V
A
P
TDSL
T
D
R
T
L
D
------
Q
M
C
T
V
T
R
P
---
G
V
A
M
M
A
S
S
L
A
V
E
L
M
-
T
S
--------
L
L
-
Q
T
--
K
-------------------
Y
----
S
G
S
E
T
--
T
V
L
G
D
I
P
H
Q
I
R
--------
G
F
L
H
N
F
S
I
L
K
L
E
T
P
A
---------
Y
E
H
----------
C
P
A
C
S
-
P
K
V
I
E
A
F
T
---
D
L
G
----------------------------
W
E
F
V
K
K
A
L
E
H
----
P
L
Y
L
E
E
I
S
G
L
S
V
I
K
Q
E
V
E
R-------------------------
9
PsiBlast_PDB
45.91
33%
-175
- C- -
3S5I
-
?
A:
[986-1037]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
L
F
D
E
E
K
---------
V
K
K
E
F
F
V
L
P
T
F
V
N
S
V
S
M
S
-
G
I
L
F
-------
K
P
G
-----------
E
-------------
Y
L
D
P
S
F
T
V
I
V
A
A
L
----
K
N
S
Y
----------------------------------------
30
Fugue
45.54
14%
-120
- C3 -
1W5C
9
PSBD_THEEB
D:
[1-350]
M
T
I
A
I
G
R
A
-----
P
A
E
R
G
--
W
F
D
I
L
D
D
W
L
K
R
D
R
F
V
F
V
----
G
W
S
G
--------------------
I
L
L
F
P
C
---
A
Y
L
A
L
G
G
W
L
--
T
G
--------
T
T
F
-
V
T
S
W
Y
--
T
-
H
G
L
A
S
S
Y
--
L
-
E
G
C
-
N
F
L
T
V
-
A
V
S
T
P
A
----
N
S
M
-
G
H
S
L
---------------
L
L
L
W
G
P
E
A
-------------
Q
G
D
F
T
----
R
W
C
--------
Q
--
L
G
-----
G
L
W
---
T
---
F
I
A
L
H
G
A
F
G
L
I
G
F
M
------------
L
--
R
Q
F
E
I
A
R
------------------
L
V
G
V
RP----
Y
N
A
I
A
F
S
A
P
I
A
V
F
V
S
V
F
L
I
Y
P
L
G
Q
S
S
--
W
F
F
A
P
S
F
G
V
A
A
----
I
F
R
F
L
-
L
F
F
Q
G
F
H
N
W
T
L
--
N
P
F
---------
H
M
M
G
---
V
A
G
V
L
G
G
A
L
L
C
A
I
H
G
A
T
V
---
E
N
T
----------------------------------------
L
-
F
-
Q
---
D
G
E
G
A
S
T
F
R
A
F
------
N
P
-------------------------------------------------------
T
Q
A
E
----
E
T
Y
S
M
V
------
T
A
N
R
F
W
S
Q
---
I
F
G
I
A
F
S
N
K
R
W
L
H
F
-
F
M
--------
L
F
-
V
P
--
V
-------------------
T
G
---
L
W
M
S
A
--
I
G
V
V
G
L
A
L
N
L
R
--------
S
Y
D
F
I
S
Q
E
I
R
A
A
E
D
P
---------
E
F
E
T
F
Y
T
K
N
L
L
L
N
E
G
I
R
A
-
W
M
A
P
Q
D
Q
P
---
H
E
N
-----------
F
------------------------------------
V
F
P
E
E
V
L
P
R
G
N
---------------------------
10
PsiBlast_PDB
45.46
33%
-208
- C4 -
3S5K
-
?
A:
[986-1037]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
L
F
D
E
E
K
---------
V
K
K
E
F
F
V
L
P
T
F
V
N
S
V
S
M
S
-
G
I
L
F
-------
K
P
G
-----------
E
-------------
Y
L
D
P
S
F
T
V
I
V
A
A
L
----
K
N
S
Y
----------------------------------------