@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03260: (2016-06-05 )
MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTALIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSGICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAFPRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLKDLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGSILLGFLES
Atome Classification :
(20 SA)
...--......10........20--.--.......30---..------.--...---..40..-......50........60....---..----.-.70-----.........80........90........100.......-110......---------.120......---.130.......140.-......150.......160.......-170-----------.--...-----.----..180--..-......190.-----..--....200.--.-.......210.......220-----.......230.......240-.......250.......260.....-..-270........280..---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKR--
R
V
E
T
I
T
FDG
G
T
L
E
Y
S
VTG--K--G
T
P
I
L
V
M
HG---GH------
S
--
N
C
Y
---
E
E
FG
Y
T
-
A
L
I
EQG
Y
S
IITPSRPGYGR
T
S
K
---
E
I
----
G
-
K
S
------
L
A
N
A
C
R
F
Y
V
K
L
L
D
HL
Q
I
E
S
V
H
V
I
A
I
SAGGP
S
G
I
C
FASHY-PERV
N
T
L
T
L
---------
Q
S
A
V
T
KEWLT---PKDTEY
K
L
G
E
I
L
FRP-
P
V
E
K
W
I
W
K
L
I
S
S
L
N
N
A
F
P
R
L
M
F
R
AMS-PQF-----------S--TL
P
-----
F
----
Q
R
I
K
---
S
L
-
M
N
E
K
D
I
E
A
F
R
-----
K
M
--
N
S
RQR--S--G-E
G
F
L
I
DLSQ
T
A
A
V
S
L
K
D
L
Q
A
-----
I
I
C
P
V
L
I
M
Q
S
V
Y
D
G
L
V
D
L
S
H
-
A
H
H
A
K
E
H
I
R
G
A
V
L
C
L
L
H
SWG
H
L
I
W
L-GK-E-AAETG
S
I
L
L
G
FLES---
15
PsiBlast_PDB
87.06
25%
-134
- C1 -
2D0D
3
?
A:
[8-252]
-------
K
S
I
L
A
A
G
V
L
T
N
Y
H
D
V
G
--
E
--
G
Q
P
V
I
L
I
H
G
---
S
G
------
P
GV
S
A
Y
---
A
N
W
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
PE-
N
Y
----
N
-
Y
S
------
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
S
F
G
G
G
L
A
I
A
T
A
L
R
Y
-
S
E
R
V
D
R
M
V
L
---------
M
G
A
V
G
-----------
T
R
F
D
V
T
E
G
L
-------
N
A
V
W
G
Y
T
P
S
I
E
N
M
R
N
L
L
D
I
F
A
Y
D
-
R
S
L
-----------
V
--
T
D
E
-----
L
----
A
R
L
R
Y
E
-
A
S
-
I
Q
P
G
F
Q
E
S
F
S
-----
S
M
FP
E
P
R
Q
R
----------
W
I
D
---
A
L
A
S
S
D
E
D
I
K
T
-----
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
L
S
S
-
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
---------------------------
18
PsiBlast_PDB
85.83
24%
-131
- C1 -
1IUP
3
?
A:
[8-252]
-------
K
S
I
L
A
A
G
V
L
T
N
Y
H
D
V
G
--
E
--
G
Q
P
V
I
L
I
H
G
---
S
G
------
P
GV
S
A
Y
---
A
N
W
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
PE-
N
Y
----
N
-
Y
S
------
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
I
A
T
A
L
R
Y
-
S
E
R
V
D
R
M
V
L
---------
M
G
A
A
G
-----------
T
R
F
D
V
T
E
G
L
-------
N
A
V
W
G
Y
T
P
S
I
E
N
M
R
N
L
L
D
I
F
A
Y
D
-
R
S
L
-----------
V
--
T
D
E
-----
L
----
A
R
L
R
Y
E
-
A
S
-
I
Q
P
G
F
Q
E
S
F
S
-----
S
M
FP
E
P
R
Q
R
----------
W
I
D
---
A
L
A
S
S
D
E
D
I
K
T
-----
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
L
S
S
-
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
---------------------------
20
PsiBlast_PDB
85.69
24%
-128
- C1 -
1UK7
1
?
A:
[8-252]
-------
K
S
I
L
A
A
G
V
L
T
N
Y
H
D
V
G
--
E
--
G
Q
P
V
I
L
I
H
G
---
S
G
------
P
GV
S
A
Y
---
A
N
W
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
PE-
N
Y
----
N
-
Y
S
------
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
I
A
T
A
L
R
Y
-
S
E
R
V
D
R
M
V
L
---------
M
G
A
A
G
-----------
T
R
F
D
V
T
E
G
L
-------
N
A
V
W
G
Y
T
P
S
I
E
N
M
R
N
L
L
D
I
F
A
Y
D
-
R
S
L
-----------
V
--
T
D
E
-----
L
----
A
R
L
R
Y
E
-
A
S
-
I
Q
P
G
F
Q
E
S
F
S
-----
S
M
FP
E
P
R
Q
R
----------
W
I
D
---
A
L
A
S
S
D
E
D
I
K
T
-----
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
L
S
S
-
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
---------------------------
19
PsiBlast_PDB
85.64
24%
-129
- C1 -
1UK6
2
?
A:
[8-252]
-------
K
S
I
L
A
A
G
V
L
T
N
Y
H
D
V
G
--
E
--
G
Q
P
V
I
L
I
H
G
---
S
G
------
P
GV
S
A
Y
---
A
N
W
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
PE-
N
Y
----
N
-
Y
S
------
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
I
A
T
A
L
R
Y
-
S
E
R
V
D
R
M
V
L
---------
M
G
A
A
G
-----------
T
R
F
D
V
T
E
G
L
-------
N
A
V
W
G
Y
T
P
S
I
E
N
M
R
N
L
L
D
I
F
A
Y
D
-
R
S
L
-----------
V
--
T
D
E
-----
L
----
A
R
L
R
Y
E
-
A
S
-
I
Q
P
G
F
Q
E
S
F
S
-----
S
M
FP
E
P
R
Q
R
----------
W
I
D
---
A
L
A
S
S
D
E
D
I
K
T
-----
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
L
S
S
-
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
---------------------------
17
PsiBlast_PDB
85.42
24%
-127
- C1 -
1IUO
2
?
A:
[8-252]
-------
K
S
I
L
A
A
G
V
L
T
N
Y
H
D
V
G
--
E
--
G
Q
P
V
I
L
I
H
G
---
S
G
------
P
GV
S
A
Y
---
A
N
W
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
PE-
N
Y
----
N
-
Y
S
------
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
I
A
T
A
L
R
Y
-
S
E
R
V
D
R
M
V
L
---------
M
G
A
A
G
-----------
T
R
F
D
V
T
E
G
L
-------
N
A
V
W
G
Y
T
P
S
I
E
N
M
R
N
L
L
D
I
F
A
Y
D
-
R
S
L
-----------
V
--
T
D
E
-----
L
----
A
R
L
R
Y
E
-
A
S
-
I
Q
P
G
F
Q
E
S
F
S
-----
S
M
FP
E
P
R
Q
R
----------
W
I
D
---
A
L
A
S
S
D
E
D
I
K
T
-----
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
L
S
S
-
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
---------------------------
16
PsiBlast_PDB
84.13
24%
-127
- C1 -
1IUN
1
?
A:
[8-252]
-------
K
S
I
L
A
A
G
V
L
T
N
Y
H
D
V
G
--
E
--
G
Q
P
V
I
L
I
H
G
---
S
G
------
P
GV
S
A
Y
---
A
N
W
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
PE-
N
Y
----
N
-
Y
S
------
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
I
A
T
A
L
R
Y
-
S
E
R
V
D
R
M
V
L
---------
M
G
A
A
G
-----------
T
R
F
D
V
T
E
G
L
-------
N
A
V
W
G
Y
T
P
S
I
E
N
M
R
N
L
L
D
I
F
A
Y
D
-
R
S
L
-----------
V
--
T
D
E
-----
L
----
A
R
L
R
Y
E
-
A
S
-
I
Q
P
G
F
Q
E
S
F
S
-----
S
M
FP
E
P
R
Q
R
----------
W
I
D
---
A
L
A
S
S
D
E
D
I
K
T
-----
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
L
S
S
-
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
---------------------------
31
HHSearch
82.41
22%
-129
- C1 -
1IUP
3
?
A:
[9-272]
--------
S
I
L
A
A
G
V
L
T
N
Y
H
D
V
G
--
E
--
G
Q
P
V
I
L
I
H
G
---
S
G
------
P
--
G
V
S
A
Y
A
N
W
R
L
T
I
-
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
---
P
E
N
Y
--
N
-
Y
S
------
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
I
A
T
A
L
R
Y
-
S
E
R
V
D
R
M
V
L
---------
M
G
A
A
G
T
R
F
D
V
---
T
E
G
---
L
N
A
V
W
G
Y
T
P
-
S
I
E
N
-
M
R
N
L
L
D
I
F
A
---
Y
D
---
R
S
L
V
-
T
D
E
---------------
L
A
-----
R
----
L
R
Y
E
---
A
S
-
I
Q
P
G
F
Q
E
S
F
S
-----
S
M
--
F
P
E
----
P
--
R
-
Q
R
W
I
D
A
L
----
A
S
S
D
E
D
I
K
T
-----
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
L
S
S
-
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
W
T
Q
I
-
E
Q
---
T
D
R
F
N
R
L
V
V
E
F
F
N
E
---
32
HHSearch
80.39
22%
-108
- C1 -
4Y7D
2
?
A:
[17-300]
--------
T
V
S
T
A
R
G
E
V
D
C
V
I
V
G
--
A
--
G
P
P
V
L
V
V
H
G
---
S
P
------
G
--
G
H
D
---
A
G
L
A
M
A
R
F
L
V
A
E
G
L
R
A
I
V
V
D
R
P
G
Y
F
G
T
P
L
---
G
S
----
G
-
V
T
------
P
D
E
Q
A
E
L
Y
A
A
L
F
D
A
L
G
L
A
A
A
G
V
L
C
W
S
G
G
G
P
S
S
Y
R
L
A
A
R
H
-
P
D
R
V
R
A
L
V
S
---------
V
A
A
V
S
H
R
Y
H
F
---
D
G
-
E
K
G
-
A
E
K
V
L
M
G
T
----
G
L
G
R
R
M
L
Q
L
M
A
A
H
T
P
E
K
L
V
S
A
T
I
-
A
A
E
-----------
G
--
H
L
S
-----
K
E
H
V
A
E
R
V
A
---
Q
I
M
A
D
P
D
K
E
R
F
T
L
-----
E
L
--
A
V
S
A
N
HS
G
PR
K
-
A
G
F
D
N
D
M
D
Q
F
A
R
I
D
S
L
E
L
D
R
-----
I
T
A
P
T
L
V
V
S
G
T
A
D
S
D
V
D
P
E
F
-
S
R
F
A
A
A
Q
I
A
G
S
E
L
V
H
L
D
A
G
T
H
L
A
F
W
-
V
H
P
D
-
S
G
P
V
R
R
R
A
A
E
L
L
R
A
---
4
PsiBlast_PDB
80.11
25%
-98
- C1 -
2PUH
2
BPHD_BURXL
A:
[14-283]
-----
K
I
N
E
K
G
F
S
D
F
N
I
H
Y
N
E
A
G
--
N
--
G
E
T
V
I
M
L
H
G
---
G
G
PGAG
G
W
S
--
N
Y
Y
---
R
N
V
G
---
P
F
V
D
A
G
Y
R
V
I
L
K
D
S
P
G
F
N
K
S
D
A
---
V
V
M
DE-
Q
-
R
G
------
L
V
N
A
-
R
A
V
K
G
L
M
D
A
L
D
I
D
R
A
H
L
V
G
N
A
M
G
G
A
T
A
L
N
F
A
L
E
Y
-
P
D
R
I
G
K
L
I
L
-----------------
M
G
---
P
G
----
G
L
G
P
S
M
F
A
P
M
P
M
E
G
-------------
I
K
L
L
F
K
L
Y
A
E
P
S
Y
-----------
E
--
T
L
K
Q
M
L
Q
V
F
----
L
Y
D
Q
---
S
L
-
I
T
E
E
L
L
Q
G
R
W
-----
E
A
--
I
Q
R
Q
P
--
E
--
H
L
K
N
F
L
I
S
-
A
Q
K
A
P
L
S
T
W
D
V
T
A
RLGE-
I
K
A
K
T
F
I
T
W
G
R
D
D
R
F
V
P
L
D
H
-
G
L
K
L
L
W
N
I
D
D
A
R
L
H
V
F
S
K
C
G
H
--
W
A
-
Q
W
-
E
H
A
D
E
F
N
R
L
V
I
D
F
L
-----
6
PsiBlast_PDB
79.96
25%
-100
- C1 -
2RHW
2
BPHD_BURXL
A:
[11-280]
-----
K
I
N
E
K
G
F
S
D
F
N
I
H
Y
N
E
A
G
--
N
--
G
E
T
V
I
M
L
H
G
---
G
G
PGAG
G
W
S
--
N
Y
Y
---
R
N
V
G
---
P
F
V
D
A
G
Y
R
V
I
L
K
D
S
P
G
F
N
K
S
D
A
---
V
V
M
DE-
Q
-
R
G
------
L
V
N
A
-
R
A
V
K
G
L
M
D
A
L
D
I
D
R
A
H
L
V
G
N
A
M
G
G
A
T
A
L
N
F
A
L
E
Y
-
P
D
R
I
G
K
L
I
L
-----------------
M
G
---
P
G
----
G
L
G
P
S
M
F
A
P
M
P
M
E
G
-------------
I
K
L
L
F
K
L
Y
A
E
P
S
Y
-----------
E
--
T
L
K
Q
M
L
Q
V
F
----
L
Y
D
Q
---
S
L
-
I
T
E
E
L
L
Q
G
R
W
-----
E
A
--
I
Q
R
Q
P
--
E
--
H
L
K
N
F
L
I
S
-
A
Q
K
A
P
L
S
T
W
D
V
T
A
RLGE-
I
K
A
K
T
F
I
T
W
G
R
D
D
R
F
V
P
L
D
H
-
G
L
K
L
L
W
N
I
D
D
A
R
L
H
V
F
S
K
C
G
H
--
W
A
-
Q
W
-
E
H
A
D
E
F
N
R
L
V
I
D
F
L
-----
7
PsiBlast_PDB
79.71
25%
-100
- C1 -
2RI6
2
BPHD_BURXL
A:
[11-280]
-----
K
I
N
E
K
G
F
S
D
F
N
I
H
Y
N
E
A
G
--
N
--
G
E
T
V
I
M
L
H
G
---
G
G
PGAGGW
S
--
N
Y
Y
---
R
N
V
G
---
P
F
V
D
A
G
Y
R
V
I
L
K
D
S
P
G
F
N
K
S
D
A
---
V
V
M
DE-
Q
-
R
G
------
L
V
N
A
-
R
A
V
K
G
L
M
D
A
L
D
I
D
R
A
H
L
V
G
N
A
M
G
G
A
T
A
L
N
F
A
L
E
Y
-
P
D
R
I
G
K
L
I
L
-----------------
M
G
---
P
G
----
G
L
G
P
S
M
F
A
P
M
P
M
E
G
-------------
I
K
L
L
F
K
L
Y
A
E
P
S
Y
-----------
E
--
T
L
K
Q
M
L
Q
V
F
----
L
Y
D
Q
---
S
L
-
I
T
E
E
L
L
Q
G
R
W
-----
E
A
--
I
Q
R
Q
P
--
E
--
H
L
K
N
F
L
I
S
-
A
Q
K
A
P
L
S
T
W
D
V
T
A
RLGE-
I
K
A
K
T
F
I
T
W
G
R
D
D
R
F
V
P
L
D
H
-
G
L
K
L
L
W
N
I
D
D
A
R
L
H
V
F
S
K
C
G
H
--
W
A
-
Q
W
-
E
H
A
D
E
F
N
R
L
V
I
D
F
L
-----
2
PsiBlast_PDB
79.29
25%
-93
- C1 -
2OG1
6
BPHD_BURXL
A:
[14-283]
-----
K
I
N
E
K
G
F
S
D
F
N
I
H
Y
N
E
A
G
--
N
--
G
E
T
V
I
M
L
H
G
---
G
G
PGAG
G
W
S
--
N
Y
Y
---
R
N
V
G
---
P
F
V
D
A
G
Y
R
V
I
L
K
D
S
P
G
F
N
K
S
D
A
---
V
V
M
DE-
Q
-
R
G
------
L
V
N
A
-
R
A
V
K
G
L
M
D
A
L
D
I
D
R
A
H
L
V
G
N
S
M
G
G
A
T
A
L
N
F
A
L
E
Y
-
P
D
R
I
G
K
L
I
L
-----------------
M
G
---
P
G
----
G
L
G
P
S
M
F
A
P
M
P
M
E
G
-------------
I
K
L
L
F
K
L
Y
A
E
P
S
Y
-----------
E
--
T
L
K
Q
M
L
Q
V
F
----
L
Y
D
Q
---
S
L
-
I
T
E
E
L
L
Q
G
R
W
-----
E
A
--
I
Q
R
Q
P
--
E
--
H
L
K
N
F
L
I
S
-
A
Q
K
A
P
L
S
T
W
D
V
T
A
RLGE-
I
K
A
K
T
F
I
T
W
G
R
D
D
R
F
V
P
L
D
H
-
G
L
K
L
L
W
N
I
D
D
A
R
L
H
V
F
S
K
C
G
H
--
W
A
-
Q
W
-
E
H
A
D
E
F
N
R
L
V
I
D
F
L
-----
1
PsiBlast_PDB
79.21
25%
-98
- C1 -
4Y7D
2
?
A:
[15-281]
------
V
Q
T
V
S
T
A
R
G
E
V
D
C
V
I
V
G
--
A
--
G
P
P
V
L
V
V
H
G
SPG
G
H
------
D
--
A
G
L
---
A
M
A
R
F
---
L
V
A
E
G
L
R
A
I
V
V
D
R
P
G
Y
F
G
T
P
L
---
G
S
----
G
-
V
T
------
P
D
E
Q
A
E
L
Y
A
A
L
F
D
A
L
G
L
A
A
A
G
V
L
C
W
S
G
G
G
P
S
S
Y
R
L
A
A
R
H
-
P
D
R
V
R
A
L
V
S
---------
V
A
A
V
S
H
R
Y
H
F
-----
D
G
E
K
G
A
E
K
V
L
M
G
T
-
G
L
G
R
R
M
L
Q
L
M
A
A
H
T
---
P
E
K
L
V
S
A
T
I
-
A
A
E
-----------
G
--
H
L
S
K
E
H
V
-
A
----
E
R
V
A
---
Q
I
-
M
A
D
P
D
K
E
R
F
T
L
E
L
A
V
S
A
--
N
H
S
G
P
--
R
--
K
-
A
G
F
D
N
D
M
D
Q
F
A
R
I
D
S
L
E
L
D
R
-----
I
T
A
P
T
L
V
V
S
G
T
A
D
S
D
V
D
P
E
F
-
S
R
F
A
A
A
Q
I
A
G
S
E
L
V
H
L
D
A
G
T
H
L
A
F
------------------------
5
PsiBlast_PDB
78.27
25%
-98
- C1 -
2RHT
3
BPHD_BURXL
A:
[11-280]
-----
K
I
N
E
K
G
F
S
D
F
N
I
H
Y
N
E
A
G
--
N
--
G
E
T
V
I
M
L
H
G
---
G
G
PGAG
G
W
S
--
N
Y
Y
---
R
N
V
G
---
P
F
V
D
A
G
Y
R
V
I
L
K
D
S
P
G
F
N
K
S
D
A
---
V
V
M
DE-
Q
-
R
G
------
L
V
N
A
-
R
A
V
K
G
L
M
D
A
L
D
I
D
R
A
H
L
V
G
N
A
M
G
G
A
T
A
L
N
F
A
L
E
Y
-
P
D
R
I
G
K
L
I
L
-----------------
M
G
---
P
G
----
G
L
G
P
S
M
F
A
P
M
P
M
E
G
-------------
I
K
L
L
F
K
L
Y
A
E
P
S
Y
-----------
E
--
T
L
K
Q
M
L
Q
V
F
----
L
Y
D
Q
---
S
L
-
I
T
E
E
L
L
Q
G
R
W
-----
E
A
--
I
Q
R
Q
P
--
E
--
H
L
K
N
F
L
I
S
-
A
Q
K
A
P
L
S
T
W
D
V
T
A
RLGE-
I
K
A
K
T
F
I
T
W
G
R
D
D
R
F
V
P
L
D
H
-
G
L
K
L
L
W
N
I
D
D
A
R
L
H
V
F
S
K
C
G
H
--
W
A
-
Q
W
-
E
H
A
D
E
F
N
R
L
V
I
D
F
L
-----
3
PsiBlast_PDB
77.82
25%
-92
- C1 -
2PU5
1
BPHD_BURXL
A:
[14-283]
-----
K
I
N
E
K
G
F
S
D
F
N
I
H
Y
N
E
A
G
--
N
--
G
E
T
V
I
M
L
H
G
---
G
G
PGAG
G
W
S
--
N
Y
Y
---
R
N
V
G
---
P
F
V
D
A
G
Y
R
V
I
L
K
D
S
P
G
F
N
K
S
D
A
---
V
V
M
DE-
Q
-
R
G
------
L
V
N
A
-
R
A
V
K
G
L
M
D
A
L
D
I
D
R
A
H
L
V
G
N
S
M
G
G
A
T
A
L
N
F
A
L
E
Y
-
P
D
R
I
G
K
L
I
L
-----------------
M
G
---
P
G
----
G
L
G
P
S
M
F
A
P
M
P
M
E
G
-------------
I
K
L
L
F
K
L
Y
A
E
P
S
Y
-----------
E
--
T
L
K
Q
M
L
Q
V
F
----
L
Y
D
Q
---
S
L
-
I
T
E
E
L
L
Q
G
R
W
-----
E
A
--
I
Q
R
Q
P
--
E
--
H
L
K
N
F
L
I
S
-
A
Q
K
A
P
L
S
T
W
D
V
T
A
RLGE-
I
K
A
K
T
F
I
T
W
G
R
D
D
R
F
V
P
L
D
H
-
G
L
K
L
L
W
N
I
D
D
A
R
L
H
V
F
S
K
C
G
H
--
W
A
-
Q
W
-
E
H
A
D
E
F
N
R
L
V
I
D
F
L
-----
27
HHSearch
71.43
16%
-123
- C1 -
3G9X
3
DHAA_RHOSO
A:
[14-291]
--------
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
R
D
--
G
T
P
V
L
F
L
H
G
---
N
P
------
T
--
S
S
Y
---
L
W
R
N
I
I
-
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
---
P
D
L---
D
-
Y
F
------
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
-
P
E
R
V
K
G
I
A
C
---------
M
E
F
I
R
P
F
P
T
W
---
D
E
-
W
P
E
F
A
R
E
T
F
Q
A
F
-
R
T
A
D
V
G
R
E
L
I
-----
I
D
Q
N
A
F
I
E
G
A
L
-
P
K
C
-----------
V
VR
P
L
T
-----
E
----
V
E
M
D
H
Y
R
E
P
F
L
K
P
V
D
R
E
P
L
W
-----
R
F
--
P
N
E
L
P
-----
I
-
A
G
E
P
A
N
I
V
A
L
V
E
A
Y
M
N
W
L
H
Q
-----
S
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
-
A
A
R
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
-
D
N
---
P
D
L
I
G
S
E
I
A
R
W
L
P
----
41
Fugue
70.27
19%
-109
- C1 -
1A88
-
PRXC_STRLI
A:
[1-275]
G
T
V
--
T
T
S
D
----
G
T
N
I
F
Y
K
D
W
G
--
P
RD
G
L
P
V
V
F
H
H
G
W
P-
L
S
------
A
--
D
D
----
W
D
N
Q
M
L
-
F
F
L
S
H
G
Y
R
V
I
A
H
D
R
R
G
H
G
R
S
D
Q
PST------
G
-
H
D
------
M
D
T
Y
A
A
D
V
A
A
L
T
E
A
L
D
L
R
G
A
V
H
I
G
H
S
T
G
G
G
E
V
A
R
Y
V
A
R
A
E
P
G
R
V
A
K
A
V
L
V
SAVPPVMV
K
S
---
D
T
N
P
D
---
G
-
L
P
L
E
V
F
D
E
F
R
--------
A
A
L
A
A
------
N
R
A
Q
F
Y
I
D
V
P
S
-
G
P
F
YGFNREGATVS
Q
--
G
L
I
-----
D
----
H
W
W
L
---
Q
G
-
M
M
-
G
A
A
N
A
H
Y
-----
E
C
--
I
A
A
F
S
--
E
----------
T
D
F
-
T
D
D
L
K
----
R
-----
I
D
V
P
V
L
V
A
H
G
T
D
D
Q
V
V
P
Y
A
D
A
A
P
K
S
A
E
L
L
A
N
A
T
L
K
S
Y
E
G
L
P
H
G
M
L
S
T---
H
-
P
E
V
L
N
P
D
L
L
A
F
V
K
S
---
24
HHSearch
69.05
21%
-114
- C1 -
3OM8
2
?
A:
[9-266]
--------
L
A
T
S
D
G
A
S
L
A
Y
R
L
D
G
A
A
E
--
K
P
L
L
A
L
S
N
S
---
I
G
------
T
--
T
L
H
---
M
W
D
A
Q
L
-
P
A
L
T
R
H
F
R
V
L
R
Y
D
A
R
G
H
G
A
S
S
V
---
P
P
G---
P
-
Y
T
------
L
A
R
L
G
E
D
V
L
E
L
L
D
A
L
E
V
R
R
A
H
F
L
G
L
S
L
G
G
I
V
G
Q
W
L
A
L
H
A
-
P
Q
R
I
E
R
L
V
L
---------
A
N
T
S
A
W
L
G
P
A
---
A
Q
-
W
D
E
R
I
A
A
V
L
Q
A
-----
E
D
M
----
S
E
T
----
A
A
G
F
L
G
N
W
F
-
P
P
A
--------------
L
L
------------------
E
--
R
A
E
P
V
V
E
R
F
R
-----
A
M
--
L
M
A
T
N
R
H
G
--
L
-
A
G
S
F
A
A
V
R
D
--
T
D
L
R
A
Q
L
A
R
-----
I
E
R
P
T
L
V
I
A
G
A
Y
D
T
V
T
A
A
S
H
-
G
E
L
I
A
A
S
I
A
G
A
R
L
V
T
L
P
-
A
V
H
L
S
N
V
-
E
F
---
P
Q
A
F
E
G
A
V
L
S
F
L
G
A
---
37
HHSearch
68.45
18%
-141
- C1 -
3QVM
4
?
A:
[27-277]
-------------------------
G
--
E
K
T
V
L
L
A
H
G
---
F
G
------
C
--
D
Q
N
---
M
W
R
F
M
L
-
P
E
L
E
K
Q
F
T
V
I
V
F
D
Y
V
G
S
G
Q
S
D
L
---
E
S
FSTK
R
Y
S
S
------
L
E
G
Y
A
K
D
V
E
E
I
L
V
A
L
D
L
V
N
V
S
I
I
G
H
S
V
S
S
I
I
A
G
I
A
S
T
H
V
-
G
D
R
I
S
D
I
T
M
---------
I
C
P
S
P
C
F
M
N
F
---
P
P
D
Y
V
G
G
F
E
----
R
D
-
D
L
E
E
L
----
I
N
L
M
D
K
N
Y
I
--
G
W
A
N
Y
L
A
P
L
V
-----------
M
--
G
A
S
--------------------
H
S
S
E
L
I
G
E
L
S
G
----
S
F
--
C
T
T
D
P
--
I
--
V
-
A
K
T
F
A
K
A
-
T
F
F
S
D
Y
R
S
L
L
E
D
-----
I
S
T
P
A
L
I
F
Q
S
A
K
D
S
L
A
S
P
E
V
-
G
Q
Y
M
A
E
N
I
P
N
S
Q
L
E
L
I
Q
A
E
G
H
C
L
H
M
-
T
D
---
A
G
L
I
T
P
L
L
I
H
F
I
Q
N
---
49
Fugue
66.89
17%
-112
- C1 -
1Y37
1
DEHA_BURSP
A:
[1-294]
M
F
E
G
F
E
R
R
L
V
D
V
G
D
V
T
I
N
C
V
V
G
G
--
S
--
G
P
A
L
L
L
L
H
G
---
F
P
------
Q
--
N
L
H
---
M
W
A
R
V
A
-
P
L
L
A
N
E
Y
T
V
V
C
A
D
L
R
G
Y
G
G
S
S
K
---
P
V
----
G
-
A
P
DHANYS
F
R
A
M
A
S
D
Q
R
E
L
M
R
T
L
G
F
E
R
F
H
L
V
G
H
D
R
G
G
R
T
G
H
R
M
A
L
D
H
-
P
D
S
V
L
S
L
A
V
---------
L
D
I
I
P
T
Y
V
M
F
E
E
V
D
R
F
V
A
R
A
Y
W
H
W
Y
F
L
Q
-
Q
P
A
P
Y
P
E
K
V
I
G
A
D
P
D
T
F
Y
E
G
C
L
F
G
W
G
-
A
T
------------------------------
G
A
---
D
G
-
F
D
P
E
Q
L
E
E
Y
R
-----
K
Q
--
W
R
D
P
A
--
A
--
I
-
H
G
S
C
C
D
Y
R
A
G
G
T
I
D
F
E
L
D
H
G
D
LG
R
Q
V
Q
C
P
A
L
V
F
S
G
S
A
G
L
M
H
S
L
F
E
-
M
Q
V
V
W
A
P
R
L
A
N
M
R
F
A
S
L
P
G
G
H
F
F
V
D
-
R
F
---
P
D
D
T
A
R
I
L
R
E
F
L
S
D
A
R
S