@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03310: (2016-06-05 )
MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVTRKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHIKDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAATAANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDPRETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDSLDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLITGKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDELPRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISETAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKGRYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTESFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARHFESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQNVNDLIGEALDPACKMPGFKVCAVRIIPI
Atome Classification :
(20 SA)
---------------------------------.........10........20........30.......--.---40..------------------------------------------......50-...-..---...--60........70.....-----.-----..80...------.-------.--.-------..90........100.......110.......120--.----..----......130.......140.......150---.........160.......170.......180.......190..-.....-----200..----------.--.---.------------.----------.--.-------.--210.......220.....--------.--------.230-.........240.......250--.......260...----------------------------------....270.......280.......290.....-..300.-.------.-.------.-----.-.-.310.......320.......330.......340----------........-----------.350.-..-.-.-..360.......370.....----..380.......390.-...-....400.......410-.........420.......------------------------------430...----.----.--.-.-440-.......450........460.......470.....---..480.......490..-..-----------------.----------------..-------------500..----.-------.-...-------------510--------------------------.....-.--------...520.-...----.---------.-----..-530--------------.--.-.-..------.-..540--------.-----------------....--..---------.550----------.....--------------.----.---560---.------------.-------.----.---.-.---------------..570.......580..-......--590.......600.......610.......620.......630.......640--.......650..--..--...--660.--....----..670......-.-680......------------..690........700.......710-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------M
T
E
R
L
L
R
Y
F
R
D
K
Q
Q
D
VQSEKTYDTQCP
F
C
S
M
Q
C
K
M
Q
L
V
--
E
---
Q
T
I
V
------------------------------------------TRK
K
Y
T
A
I-GID-NP---TTQ--
G
R
L
C
IKGM
N
A
H
Q
HAL
N
S
-----
S
-----RI
T
R
P
L
L
------K-------K--N-------GEFMPV
S
W
E
E
A
L
N
H
I
K
D
Q
V
T
M
I
Q
TEHGHD
A
M
A
V
----Y----GS----ASITN
E
E
A
Y
L
L
G
K
F
A
RVG
L
Q
T
K
Y
IDYN-----G
R
L
C
M
S
A
A
A
T
AANQTFGADRGLTNPLSDIPH
T
R
V
I
I
L
AGT
N
I
AE-CQ
P
T
I
-----
M
--
P
Y
----------
F
--
E
---
K
------------A----------K--E-------N--G
A
Y
F
I
A
IDPRETA
T
T
K
I
A
--------
D
--------
L
H
---
L
K
IKPGT
D
A
A
L
AN
G
L
V
K
I
I
ID
E
--
Q
LI
N
E
D
F
I
Q
S
R
TN----------------------------------
G
F
E
E
L
K
Q
H
TDSL
D
L
N
D
I
A
E
Q
TS
V
S
L
V
D
I
R
K
A
A
-
V
K
F
-
A
K
-E------T-S------
G
-----
M
-
L
-
F
T
ARGIEQQTD
G
T
A
A
V
K
G
F
L
N
M
V
L
I
TGKIGKP------------YSG
Y
G
A
IT-----------GQGNG-Q
G
-
A
-
R
-
E
HGQKADQLPGYRSIE
N
E
E
H
----
R
A
H
I
A
K
V
WGI
H
Q
D
E-L-PRK-G
V
S
A
Y
E
M
M
E
KINDGD---
I
K
G
L
F
L
M
CSNPAVSSP
N
A
N
------------------------------
L
V
K
K
A
L
----
R
----
R
--
L
-
T
-
F
F
V
-
A
I
D
L
F
I
S
E-TAKY
A
D
V
I
LP
A
S
SYLEDEG
T
M
TNV
E
G
R
---
V
T
L
REASRPCPGEAKH
D
-
W
Q
-----------------
I
----------------
I
C
-------------
D
L
A
S
A
----L-------G-KG
R
-------------
Y
----------------------------
F
S
YT
S
-
A
--------
E
D
I
F
N
-
E
-
L
R
E
----A---------S-----RG-GI---------------A--D-Y-SG------I-SY
G
R
---------
L
-----------------RREG--GI---------HWPC----------PESDH--------------P----G---TG----R------------
L
-------
F
----
T
---
E
-S---------------FAHPD
Q
K
A
A
L
SVIP-NE-PPVPKE--KPTADY
P
L
Y
L
T
T
G
R
V
M
S
H
Y
L
T
G
V
Q
T
R
K
S
A
A
L
A
A
R
H
F
E
S
F
M
E
IHPQT
A
A
T
YNIE--
D
R
V
L
V
K
I
ESPRG--
S
I
--
T
V
R
--
S
K
L
S
--
E
Q
I
R----KD
T
V
F
V
P
I
HWA-D-A-Q
N
V
N
D
L
I
------------
G
E
AL-D
P
A
CKMPG
F
K
V
C
A
V
R
I
IPI-------------------
8
PsiBlast_PDB
78.07
31%
-73
- C3 -
2V3V
9
NAPA_DESDA
A:
[3-720]
------------------------------------------------
N
R
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
---------
V
------------------------------------------
K
D
G
K
A
V
A
I
Q
G
D
P
-
N
N
---
H
N
A
--
G
L
L
C
L
K
G
-
S
L
L
I
P
V
L
N
S
-----
K
E----
R
V
T
Q
P
L
V
------
R
RH-----
K
--
G
-------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
----
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
-
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-----
F
--
R
R
----------
I
--
A
---
R
------------
R
----------
K
Q
V
E
-------
P
--
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
--------
M
H
---
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
--
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
-
R
A
F
-
A
E
-
S
------
A
-
A
------
T
-----
M
-
S
-
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
------------
G
A
T
S
F
S
L
T
-----------
G
Q
P
N
A
C
G
G
-
V
-
R
-
D
G
G
A
L
S
H
L
L
P
A
G
R
A
I
P
N
A
K
H
----
R
A
E
M
E
K
L
W
G
L
P
E
G
R
-
I
A
P
E
P
-
G
Y
H
T
V
A
L
F
E
A
L
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
------------------------------
K
V
H
K
A
M
----
S
----
H
--
P
E
S
-
F
I
V
-
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
-----------------
T
----------------
L
V
-------------
E
F
A
R
R
----
A
-------
G
V
D
P
Q
-------------
L
----------------------------
V
N
F
R
N
-
A
--------
E
D
V
W
N
-
E
-
W
R
M
----
V
---------
S
-----
K
G
-
T
T
---------------
Y
--
D
-
F
-
W
G
------
M
-
T
R
E
R
---------
L
-----------------
R
K
E
S
--
G
L
---------
I
W
P
C
----------
P
S
E
D
H
--------------
P
----
G
---
T
S
----
L
------------
R
-------
Y
----
V
---
R
-
G
QDPCVPADHPDRFFF
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
-
G
A
A
--
E
--
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
--
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
--
A
R
V
S
--
D
V
C
R
----
P
G
L
I
A
V
P
F
-
F
D
-
P
-
K
-
K
L
V
N
K
L
F
------------
L
D
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
C
A
A
R
V
----------------------
1
PsiBlast_PDB
77.45
31%
-72
- C3 -
2NAP
5
NAPA_DESDA
A:
[4-720]
-------------------------------------------------
R
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
-----------
L
V
------------------------------------------
G
V
K
D
G
K
A
V
-
A
I
Q
G
N
P
---
N
N
H
NA
G
L
L
C
L
K
G
-
S
L
L
I
P
V
L
N
S
-----
K
E----
R
V
T
Q
P
L
V
------
R
RH-----
K
--
G
-------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
----
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
-
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-----
F
--
R
R
----------
I
--
A
---
R
------------
R
----------
K
Q
V
E
-------
P
--
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
--------
M
H
---
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
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I
N
E
--
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
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Q
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Y
G
A
A
-
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A
F
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A
E
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S
------
A
-
A
------
T
-----
M
-
S
-
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
------------
G
A
T
S
F
S
L
T
-----------
G
Q
P
N
A
C
G
G
-
V
-
R
-
D
G
G
A
L
S
H
L
L
P
A
G
R
A
I
P
N
A
K
H
----
R
A
E
M
E
K
L
W
G
L
P
E
G
R
-
I
A
P
E
P
-
G
Y
H
T
V
A
L
F
E
A
L
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
------------------------------
K
V
H
K
A
M
----
S
----
H
--
P
E
S
-
F
I
V
-
C
I
E
A
F
P
D
A
V
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L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
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V
N
-----------------
T
----------------
L
V
-------------
E
F
A
R
R
----
A
-------
G
V
D
P
Q
-------------
L
----------------------------
V
N
F
R
N
-
A
--------
E
D
V
W
N
-
E
-
W
R
M
----
V
---------
S
-----
K
G
-
T
T
---------------
Y
--
D
-
F
-
W
G
------
M
-
T
R
E
R
---------
L
-----------------
R
K
E
S
--
G
L
---------
I
W
P
C
----------
P
S
E
D
H
--------------
P
----
G
---
T
S
----
L
------------
R
-------
Y
----
V
---
R
-
G
QDPCVPADHPDRFFF
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
-
G
A
A
--
E
--
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
--
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
--
A
R
V
S
--
D
V
C
R
----
P
G
L
I
A
V
P
F
-
F
D
-
P
-
K
-
K
L
V
N
K
L
F
------------
L
D
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
C
A
A
R
V
----------------------
5
PsiBlast_PDB
77.37
31%
-72
- C3 -
2V45
6
NAPA_DESDA
A:
[2-720]
-----------------------------------------------
D
N
R
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
-----------
L
V
------------------------------------------
G
V
K
D
G
K
A
V
-
A
I
Q
G
N
P
---
N
N
H
NA
G
L
L
C
L
K
G
-
S
L
L
I
P
V
L
N
S
-----
K
E----
R
V
T
Q
P
L
V
------
R
RH-----
K
--
G
-------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
----
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
-
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-----
F
--
R
R
----------
I
--
A
---
R
------------
R
----------
K
Q
V
E
-------
P
--
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
--------
M
H
---
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
--
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
-
R
A
F
-
A
E
-
S
------
A
-
A
------
T
-----
M
-
S
-
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
------------
G
A
T
S
F
S
L
T
-----------
G
Q
P
N
A
C
G
G
-
V
-
R
-
D
G
G
A
L
S
H
L
L
P
A
G
R
A
I
P
N
A
K
H
----
R
A
E
M
E
K
L
W
G
L
P
E
G
R
-
I
A
P
E
P
-
G
Y
H
T
V
A
L
F
E
A
L
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
------------------------------
K
V
H
K
A
M
----
S
----
H
--
P
E
S
-
F
I
V
-
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
-----------------
T
----------------
L
V
-------------
E
F
A
R
R
----
A
-------
G
V
D
P
Q
-------------
L
----------------------------
V
N
F
R
N
-
A
--------
E
D
V
W
N
-
E
-
W
R
M
----
V
---------
S
-----
K
G
-
T
T
---------------
Y
--
D
-
F
-
W
G
------
M
-
T
R
E
R
---------
L
-----------------
R
K
E
S
--
G
L
---------
I
W
P
C
----------
P
S
E
D
H
--------------
P
----
G
---
T
S
----
L
------------
R
-------
Y
----
V
---
R
-
G
QDPCVPADHPDRFFF
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
-
G
A
A
--
E
--
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
--
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
--
A
R
V
S
--
D
V
C
R
----
P
G
L
I
A
V
P
F
-
F
D
-
P
-
K
-
K
L
V
N
K
L
F
------------
L
D
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
C
A
A
R
V
----------------------
7
PsiBlast_PDB
77.22
31%
-72
- C3 -
2JIQ
12
NAPA_DESDA
A:
[4-720]
-------------------------------------------------
R
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
---------
V
------------------------------------------
K
D
G
K
A
V
A
I
Q
G
D
P
-
N
N
---
H
N
A
--
G
L
L
C
L
K
G
-
S
L
L
I
P
V
L
N
S
-----
K
E----
R
V
T
Q
P
L
V
------
R
RH-----
K
--
G
-------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
----
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
-
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-----
F
--
R
R
----------
I
--
A
---
R
------------
R
----------
K
Q
V
E
-------
P
--
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
--------
M
H
---
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
--
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
-
R
A
F
-
A
E
-
S
------
A
-
A
------
T
-----
M
-
S
-
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
------------
G
A
T
S
F
S
L
T
-----------
G
Q
P
N
A
C
G
G
-
V
-
R
-
D
G
G
A
L
S
H
L
L
P
A
G
R
A
I
P
N
A
K
H
----
R
A
E
M
E
K
L
W
G
L
P
E
G
R
-
I
A
P
E
P
-
G
Y
H
T
V
A
L
F
E
A
L
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
------------------------------
K
V
H
K
A
M
----
S
----
H
--
P
E
S
-
F
I
V
-
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
-----------------
T
----------------
L
V
-------------
E
F
A
R
R
----
A
-------
G
V
D
P
Q
-------------
L
----------------------------
V
N
F
R
N
-
A
--------
E
D
V
W
N
-
E
-
W
R
M
----
V
---------
S
-----
K
G
-
T
T
---------------
Y
--
D
-
F
-
W
G
------
M
-
T
R
E
R
---------
L
-----------------
R
K
E
S
--
G
L
---------
I
W
P
C
----------
P
S
E
D
H
--------------
P
----
G
---
T
S
----
L
------------
R
-------
Y
----
V
---
R
-
G
QDPCVPADHPDRFFF
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
-
G
A
A
--
E
--
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
--
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
--
A
R
V
S
--
D
V
C
R
----
P
G
L
I
A
V
P
F
-
F
D
-
P
-
K
-
K
L
V
N
K
L
F
------------
L
D
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
C
A
A
R
V
----------------------
6
PsiBlast_PDB
76.59
31%
-71
- C3 -
2JIO
5
NAPA_DESDA
A:
[4-720]
-------------------------------------------------
R
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
---------
V
------------------------------------------
K
D
G
K
A
V
A
I
Q
G
D
P
-
N
N
---
H
N
A
--
G
L
L
C
L
K
G
-
S
L
L
I
P
V
L
N
S
-----
K
E----
R
V
T
Q
P
L
V
------
R
RH-----
K
--
G
-------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
----
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
-
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-----
F
--
R
R
----------
I
--
A
---
R
------------
R
----------
K
Q
V
E
-------
P
--
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
--------
M
H
---
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
--
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEG
K
P
S
-------------------------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
-
R
A
F
-
A
E
-
S
------
A
-
A
------
T
-----
M
-
S
-
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
------------
G
A
T
S
F
S
L
T
-----------
G
Q
P
N
A
C
G
G
-
V
-
R
-
D
G
G
A
L
S
H
L
L
P
A
G
R
A
I
P
N
A
K
H
----
R
A
E
M
E
K
L
W
G
L
P
E
G
R
-
I
A
P
E
P
-
G
Y
H
T
V
A
L
F
E
A
L
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
------------------------------
K
V
H
K
A
M
----
S
----
H
--
P
E
S
-
F
I
V
-
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
-----------------
T
----------------
L
V
-------------
E
F
A
R
R
----
A
-------
G
V
D
P
Q
-------------
L
----------------------------
V
N
F
R
N
-
A
--------
E
D
V
W
N
-
E
-
W
R
M
----
V
---------
S
-----
K
G
-
T
T
---------------
Y
--
D
-
F
-
W
G
------
M
-
T
R
E
R
---------
L
-----------------
R
K
E
S
--
G
L
---------
I
W
P
C
----------
P
S
E
D
H
--------------
P
----
G
---
T
S
----
L
------------
R
-------
Y
----
V
---
R
-
G
QDPCVPADHPDRFFF
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
-
G
A
A
--
E
--
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
--
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
--
A
R
V
S
--
D
V
C
R
----
P
G
L
I
A
V
P
F
-
F
D
-
P
-
K
-
K
L
V
N
K
L
F
------------
L
D
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
C
A
A
R
V
----------------------
2
PsiBlast_PDB
76.57
31%
-71
- C3 -
2JIM
5
NAPA_DESDA
A:
[4-720]
-------------------------------------------------
R
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
-----------
L
V
------------------------------------------
G
V
K
D
G
K
A
V
-
A
I
Q
G
N
P
---
N
N
H
NA
G
L
L
C
L
K
G
-
S
L
L
I
P
V
L
N
S
-----
K
E----
R
V
T
Q
P
L
V
------
R
RH-----
K
--
G
-------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
----
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
-
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-----
F
--
R
R
----------
I
--
A
---
R
------------
R
----------
K
Q
V
E
-------
P
--
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
--------
M
H
---
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
--
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEG
K
P
S
-------------------------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
-
R
A
F
-
A
E
-
S
------
A
-
A
------
T
-----
M
-
S
-
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
------------
G
A
T
S
F
S
L
T
-----------
G
Q
P
N
A
C
G
G
-
V
-
R
-
D
G
G
A
L
S
H
L
L
P
A
G
R
A
I
P
N
A
K
H
----
R
A
E
M
E
K
L
W
G
L
P
E
G
R
-
I
A
P
E
P
-
G
Y
H
T
V
A
L
F
E
A
L
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
------------------------------
K
V
H
K
A
M
----
S
----
H
--
P
E
S
-
F
I
V
-
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
-----------------
T
----------------
L
V
-------------
E
F
A
R
R
----
A
-------
G
V
D
P
Q
-------------
L
----------------------------
V
N
F
R
N
-
A
--------
E
D
V
W
N
-
E
-
W
R
M
----
V
---------
S
-----
K
G
-
T
T
---------------
Y
--
D
-
F
-
W
G
------
M
-
T
R
E
R
---------
L
-----------------
R
K
E
S
--
G
L
---------
I
W
P
C
----------
P
S
E
D
H
--------------
P
----
G
---
T
S
----
L
------------
R
-------
Y
----
V
---
R
-
G
QDPCVPADHPDRFFF
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
-
G
A
A
--
E
--
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
--
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
--
A
R
V
S
--
D
V
C
R
----
P
G
L
I
A
V
P
F
-
F
D
-
P
-
K
-
K
L
V
N
K
L
F
------------
L
D
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
C
A
A
R
V
----------------------
4
PsiBlast_PDB
76.19
31%
-70
- C3 -
2JIR
6
NAPA_DESDA
A:
[4-720]
-------------------------------------------------
R
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
-----------
L
V
------------------------------------------
G
V
K
D
G
K
A
V
-
A
I
Q
G
N
P
---
N
N
H
NA
G
L
L
C
L
K
G
-
S
L
L
I
P
V
L
N
S
-----
K
E----
R
V
T
Q
P
L
V
------
R
RH-----
K
--
G
-------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
----
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
-
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-----
F
--
R
R
----------
I
--
A
---
R
------------
R
----------
K
Q
V
E
-------
P
--
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
--------
M
H
---
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
--
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
-
R
A
F
-
A
E
-
S
------
A
-
A
------
T
-----
M
-
S
-
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
------------
G
A
T
S
F
S
L
T
-----------
G
Q
P
N
A
C
G
G
-
V
-
R
-
D
G
G
A
L
S
H
L
L
P
A
G
R
A
I
P
N
A
K
H
----
R
A
E
M
E
K
L
W
G
L
P
E
G
R
-
I
A
P
E
P
-
G
Y
H
T
V
A
L
F
E
A
L
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
------------------------------
K
V
H
K
A
M
----
S
----
H
--
P
E
S
-
F
I
V
-
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
-----------------
T
----------------
L
V
-------------
E
F
A
R
R
----
A
-------
G
V
D
P
Q
-------------
L
----------------------------
V
N
F
R
N
-
A
--------
E
D
V
W
N
-
E
-
W
R
M
----
V
---------
S
-----
K
G
-
T
T
---------------
Y
--
D
-
F
-
W
G
------
M
-
T
R
E
R
---------
L
-----------------
R
K
E
S
--
G
L
---------
I
W
P
C
----------
P
S
E
D
H
--------------
P
----
G
---
T
S
----
L
------------
R
-------
Y
----
V
---
R
-
G
QDPCVPADHPDRFFF
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
-
G
A
A
--
E
--
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
--
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
--
A
R
V
S
--
D
V
C
R
----
P
G
L
I
A
V
P
F
-
F
D
-
P
-
K
-
K
L
V
N
K
L
F
------------
L
D
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
C
A
A
R
V
----------------------
3
PsiBlast_PDB
75.88
31%
-72
- C3 -
2JIP
5
NAPA_DESDA
A:
[4-720]
-------------------------------------------------
R
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
-----------
L
V
------------------------------------------
G
V
K
D
G
K
A
V
-
A
I
Q
G
N
P
---
N
N
H
NA
G
L
L
C
L
K
G
-
S
L
L
I
P
V
L
N
S
-----
K
E----
R
V
T
Q
P
L
V
------
R
RH-----
K
--
G
-------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
----
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
-
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-----
F
--
R
R
----------
I
--
A
---
R
------------
R
----------
K
Q
V
E
-------
P
--
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
--------
M
H
---
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
--
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
-
R
A
F
-
A
E
-
S
------
A
-
A
------
T
-----
M
-
S
-
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
------------
G
A
T
S
F
S
L
T
-----------
G
Q
P
N
A
C
G
G
-
V
-
R
-
D
G
G
A
L
S
H
L
L
P
A
G
R
A
I
P
N
A
K
H
----
R
A
E
M
E
K
L
W
G
L
P
E
G
R
-
I
A
P
E
P
-
G
Y
H
T
V
A
L
F
E
A
L
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
------------------------------
K
V
H
K
A
M
----
S
----
H
--
P
E
S
-
F
I
V
-
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
-----------------
T
----------------
L
V
-------------
E
F
A
R
R
----
A
-------
G
V
D
P
Q
-------------
L
----------------------------
V
N
F
R
N
-
A
--------
E
D
V
W
N
-
E
-
W
R
M
----
V
---------
S
-----
K
G
-
T
T
---------------
Y
--
D
-
F
-
W
G
------
M
-
T
R
E
R
---------
L
-----------------
R
K
E
S
--
G
L
---------
I
W
P
C
----------
P
S
E
D
H
--------------
P
----
G
---
T
S
----
L
------------
R
-------
Y
----
V
---
R
-
G
QDPCVPADHPDRFFF
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
-
G
A
A
--
E
--
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
--
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
--
A
R
V
S
--
D
V
C
R
----
P
G
L
I
A
V
P
F
-
F
D
-
P
-
K
-
K
L
V
N
K
L
F
------------
L
D
A
T
-
D
P
V
S
R
E
P
E
Y
K
I
C
A
A
R
V
----------------------
17
PsiBlast_PDB
74.78
23%
0
- C- -
1G8K
5
AIOA_ALCFA
A:
[119-772]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
A
P
R
L
------
Y
-------
A
--
A
-------
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
C
F
D
H
----
G
G
----
A
G
G
G
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
-----
N
R
P
A
Y
N
S
E
C
H
A
T
R
E
M
G
I
G
E
--
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
Q
T
N
Y
F
L
NH
W
L
--
P
N
----------
L
--
Q
---
G
------------
A
T
T
S
K
K
K
E
R
F
P
N
--
E
-------
N
F
P
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
I
A
--------
R
H
V
AGNDRV
L
H
---
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
--
G
W
I
D
K
P
F
I
E
A
H
T
K
----------------------------------
G
F
D
D
A
V
K
-
T
N
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
Y
-
K
P
-
K
------
A
-
S
------
G
QAPR
T
M
-
H
-
A
Y
E
K
G
I
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
--------------
R
G
T
G
C
V
R
-----------------
M
G
-
G
-
H
-
Q
E
G
Y
T
R
P
P
Y
P
G
D
K
K
I
Y
I
D
Q
E
L
I
K
G
K
G
R
I
M
T
W
W
G
C
N
N
F
Q
-
T
-
S
N
N
-
A
Q
A
L
R
E
A
I
--
L
Q
R
S
A
---
I
V
K
Q
A
M
Q
K
A
R
G
A
T
T
E
E
M
V
D
------------------------------
V
I
Y
E
A
T
----
Q
----
N
--
G
-
G
-
L
F
V
T
S
I
N
L
Y
P
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-
C
L
-----------------
I
----------------
A
A
-------------
R
I
A
N
A
----
L
R
D
M
Y
Q
K
D
G
-
K
A
E
-------------
M
A
A
Q
F
EG----------------------
F
D
W
K
T
-
E
--------
E
D
A
F
N
-
D
G
F
R
R
----
A
---------
G
-----
Q
P
-
G
A
---------------
P
A
I
D
-
S
-
Q
G
GSTGHL
V
-
T
Y
D
R
---------
L
-----------------
R
K
S
G
NN
G
V
---------
Q
L
P
V
----------
V
S
W
D
E
--------------
S
K
G
L
V
G
---
T
E
----
M
------------
L
-------
Y
----
T
---
E
-
G
K--------------
F
D
T
D
D
G
K
A
H
F
K
P
A
P
W
N
G
-
L
P
A
T
V
Q
--
Q
Q
K
D
K
Y
R
F
W
L
N
N
G
R
N
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
--
G
G
D
I
V
E
V
Y
N
D
F
G
--
S
T
--
F
A
M
--
V
Y
P
V
--
A
E
I
K
----
R
G
Q
T
F
M
------------------------------------------------------------------------
31
HHSearch
74.23
32%
-64
- C3 -
2NAP
5
NAPA_DESDA
A:
[5-723]
--------------------------------------------------
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
--
V
---
K
D
G
-------------------------------------------
K
A
V
A
I
Q
G
--
N
P
N
-
N
----
H
N
A
--
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
K
-----
E
-----
R
V
T
Q
P
L
V
------
R
-------
R
HK
G
-------
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
----
Y
----
G
S
----
G
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
-
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-----
F
--
R
R
----------
I
--
A
---
R
------------
R
----------
K
Q
V
E
-------
P
--
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
--------
M
H
---
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
EL
D
N
--
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPS-------------------------
D
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
-
R
A
F
-
A
E
-
S
------
A
-
A
------
T
-----
M
-
S
-
L
W
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
------------
G
A
T
S
F
S
L
T
-----------
G
Q
P
N
A
-
C
G
-
G
V
R
-
D
G
G
A
L
S
H
L
L
P
A
G
R
A
I
P
N
A
K
H
----
R
A
E
M
E
K
L
W
G
L
P
E
G
R
I
A
-
P
E
P
-
G
Y
H
T
V
A
L
F
E
A
L
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
------------------------------
K
V
H
K
A
M
----
S
----
H
--
P
E
S
-
F
I
V
-
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
-----------------
T
----------------
L
V
-------------
E
F
A
R
R
----
A
-------
G
-
V
D
P
Q------------
L
----------------------------
V
N
F
R
N
-
A
--------
E
D
V
W
N
-
E
-
W
R
M
----
V
---------
S
-----
K
G
-
T
T
---------------
Y
--
D
-
F
-
W
G
------
M
-
T
R
E
R
---------
L
-----------------
R
K
E
S
--
G
L
---------
I
W
P
C
----------
P
S
E
D
H
--------------
P
----
G
---
T
S
----
L
RYVRGQDPCVPA
D
-------
H
----
P
DRF
F
-
F
---------------
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
-
A
K
-
G
A
--
A
E
--
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
--
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
--
A
R
V
S
--
D
V
C
R
----
P
G
L
I
A
V
P
F
F
D
P
K
K
-
L
-
V
N
K
L
F
L
D
------------
A
T
D
P
V
S
---
R
E
P
E
Y
K
I
C
A
A
R
V
R
K
A
-------------------
39
HHSearch
72.91
23%
0
- C- -
1G8K
5
AIOA_ALCFA
A:
[13-807]
--------------------------------------------------
N
A
Q
R
T
N
M
T
C
H
F
C
I
V
G
C
G
Y
H
V
Y
--
K
---
W
P
E
L
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
Y
D
I
M
V
V
P
--
D
K
A
-
C
V
---
V
N
S
--
G
L
S
S
T
R
G
G
K
M
A
S
Y
M
Y
T
P
TGDGK
E
-----
R
L
S
A
P
R
L
------
Y
-------
A
--
A
-------
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
----
S
----
C
F
DHGG
A
G
G
G
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
NRPAY
N
S
E
C
H
A
T
R
------
E
M
G
I
G
E
-
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
Q
T
N
Y
-----
F
L
N
H
W
----------
L
--
P
N
L
Q
G
AT
T
S
K
K
K
E
R
F
PN
E
----------
N
--
F
-------
P
--
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
I
A
R
H
V
AGNDR
V
--------
L
H
---
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
GW
I
D
--
K
P
F
I
E
A
H
T
K
----------------------------------
G
F
D
D
A
V
K
T
-
N
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
-
E
W
S
-
Y
K
-
P
KASGQA
P
-
R
------
T
-----
M
-
H
-
A
Y
E
K
G
I
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
------------
G
T
G
C
V
R
M
G
-----------
G
H
Q
E
G
-
Y
T
----------
R
P
P
Y
P
G
D
-----------------------------------
K
K
I
Y
I
D
Q
E
L
I
K
G
K
---
G
R
I
M
T
W
W
G
C
N
N
F
Q
T
S
N
N
A
Q
A
L
R
E
A
I
L
Q
R
S
A
I
V
K
Q
A
M
Q
K
ARGAT
T
E
E
M
V
D
V
I
Y
E
A
T
----
Q
----
N
--
G
G
L
-
F
V
T
-
S
I
N
L
Y
P
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-
C
L
-----------------
I
----------------
A
A
-------------
R
I
A
N
A
----
L
-------
R
-
D
M
Y
Q
K
D
GK
A
E
M
A
A
Q
F
E
G
----------------------------
F
D
W
K
T
-
E
--------
E
D
A
F
N
-
D
-
G
F
R
----
R
---------
A
GQPGA
P
A
-
I
D
S
QGG-----------
S
--
T
-
G
-
H
L
------
V
-
T
Y
D
R
---------
L
-----------------
R
K
S
G
NN
G
V
---------
Q
L
P
V
----------
V
S
W
D
E
--------------
S
K
G
L
V
G
---
T
E
----
M
L-----------
Y
-------
T
----
E
---
G
-
K
---------------
F
D
T
D
D
G
K
A
H
F
K
P
A
P
-
W
N
-
G
L
-
P
A
T
V
Q
Q
Q
K
D
K
Y
R
F
W
L
N
N
G
R
N
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
--
G
G
D
I
V
E
V
Y
N
D
F
G
--
S
T
--
F
A
M
--
V
Y
P
V
--
A
E
I
K
----
R
G
Q
T
F
M
L
F
G
Y
V
-
N
G
I
-
Q
G
D
V
T
T
-------------
D
W
T
D
R
D
---
I
I
P
Y
Y
K
G
T
W
G
D
I
R
K
V
-------------------
55
Fugue
71.97
22%
0
- C- -
1G8K
6
AIOA_ALCFA
A:
[4-825]
ND
R
I
T
L
P
P
AN
A
Q
R
T
N
M
T
CHFCIVG
C
G
Y
H
V
Y
K
W
P
E
L
E
E
G
G
R
A
P
E
Q
N
A
L
G
L
D
F
R
K
Q
L
P
P
L
A
V
T
L
T
P
A
M
T
N
V
V
T
--
E
---
H
D
G
A
------------------------------------------
R
Y
D
I
M
V
V
P
-
D
K
A
-
C
V
---
V
N
S
--
G
L
S
S
T
R
G
G
K
M
A
S
Y
M
Y
T
P
-----
T
GDGKE
R
L
S
A
P
R
L
------
Y
-------
A
--
A
-------
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
----
S
C
F
DH
G
G
----
A
G
G
G
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
-----
N
R
P
A
Y
N
S
E
C
-
H
A
T
R
E
M
G
I
G
-
E
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
Q
T
N
Y
-----
F
--
L
N
H
W
L
P
N
L
Q
GAT
T
--
S
---
K
------------
K
----------
K
--
E
R
F
PN
E
N
F
P
--
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
I
A
--------
R
H
V
AGNDRV
L
H
---
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
--
G
W
I
D
K
P
F
I
E
A
H
T
K
----------------------------------
G
F
D
D
A
V
K
T
N
R
L
-
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
-
E
W
S
-
Y
K
-
P
------
K
-
A
SGQAPR
T
-----
M
-
H
-
A
Y
E
K
G
I
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
------------
G
T
G
C
V
R
M
G
-----------
G
H
Q
E
G
-
Y
T
-
R
-
P
-
P
Y
P
G
D
K
---
K
I
Y
I
D
Q
E
L
I
K
G
----
K
G
R
I
M
T
W
W
G
C
N
N
F
Q
-
T
-
S
N
N
-
A
Q
A
L
R
E
A
I
L
Q
--
R
S
A
---
I
V
K
Q
A
M
Q
K
A
R
G
A
T
T
E
E
M
V
D
------------------------------
V
I
Y
E
A
T
----
Q
----
N
--
G
-
G
L
F
V
T
-
S
I
N
L
Y
P
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-
C
L
-----------------
I
----------------
A
A
-------------
R
I
A
N
A
----
L
-------
R
-
D
M
Y
-------------
Q
K
D
GK
A
E
M
A
A
Q
F
EG---------------
F
D
W
K
T
-
E
--------
E
D
A
F
N
-
D
-
G
F
R
----
R
AGQPGA
P
A
I
D
-----
S
Q
-
G
G
---------------
S
--
T
-
G
-
H
L
------
V
-
T
Y
D
R
---------
L
-----------------
R
K
S
G
NN
G
V
---------
Q
L
P
V
----------
V
S
W
D
E
--------------
S
K
G
L
V
G
---
T
E
----
M
------------
L
-------
Y
----
T
---
E
G
K
---------------
F
D
T
D
D
G
K
A
H
F
K
P
A
P
-
W
N
G
L
P
A
T
V
Q
--
Q
Q
K
D
K
Y
R
F
W
L
N
N
G
R
N
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
--
G
G
D
I
V
E
V
Y
N
D
F
G
--
S
T
--
F
A
M
--
V
Y
P
V
--
A
E
I
K
----
R
G
Q
T
F
M
L
F
G
Y
V
-
N
---
G
I
Q
G
D
V
T
------------
T
D
W
T
-
D
R
D
-
I
I
P
Y
Y
K
G
T
W
G
D
I
R
K
V
GSM
S
E
F
K
R
TVSFKSRRFG-
10
PsiBlast_PDB
68.09
27%
-49
- C3 -
2NYA
4
NAPA_ECOLI
A:
[10-789]
----------------------------------------------------------
C
R
F
C
G
T
G
C
G
V
L
V
G
--
T
---
Q
Q
--------------------------------------------
G
R
V
V
A
C
Q
G
-
D
P
D
-
A
P
---
V
N
R
--
G
L
N
C
I
K
G
Y
F
L
P
K
I
M
Y
G
K
-----
D
-----
R
L
T
Q
P
L
L
------
R
MKNGKYD
K
--
E
-------
G
E
F
T
P
I
T
W
D
Q
A
F
D
V
M
E
E
K
F
K
T
A
L
K
E
K
G
P
E
S
I
G
M
----
F
----
G
S
----
G
Q
W
T
I
W
E
G
Y
A
A
S
K
L
F
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
V
V
G
F
M
R
T
F
G
M
D
E
P
M
-
G
C
Y
D
D
I
E
Q
A
D
A
F
V
L
W
G
A
N
M
A
E
-
M
H
P
I
L
-----
W
--
S
R
----------
I
T
N
R
---
R
------------
L
----------
S
--
N
-------
Q
--
N
V
T
V
A
V
L
S
T
Y
Q
H
R
S
F
E
L
A
--------
D
--------
N
G
---
I
I
F
T
P
Q
S
D
L
V
I
L
N
Y
I
A
N
Y
I
I
Q
N
--
N
A
I
N
Q
D
F
F
S
K
H
V
N
L
R
K
G
A
T
DIGYGLRPTH
P
L
E
K
A
AKNPGSDASEPM-
S
F
E
D
Y
K
A
F
V
A
E
Y
T
L
E
K
T
A
E
M
T
G
V
P
K
D
Q
L
E
Q
L
A
-
Q
L
Y
-
A
D
-
P
------
N
-
K
------
K
-----
V
-
I
S
Y
W
T
M
G
F
N
Q
H
T
R
G
V
W
A
N
N
L
V
Y
N
L
H
L
L
T
G
K
I
S
Q
P
------------
G
C
G
P
F
S
L
T
-----------
G
Q
P
S
A
-
C
G
T
A
-
R
-
E
V
G
T
F
A
H
R
L
P
A
D
M
V
V
T
N
E
K
H
----
R
D
I
C
E
K
K
W
N
I
P
S
G
T
-
I
-
P
A
K
I
G
L
H
A
V
A
Q
D
R
A
L
K
D
G
K
---
L
N
V
Y
W
T
M
C
T
N
N
M
Q
A
G
P
N
I
N
------------------------------
E
E
R
M
P
G
----
W
----
R
DP
R
-
N
-
F
I
I
-
V
S
D
P
Y
P
T
V
-
S
A
L
A
A
D
L
I
L
P
T
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
---
T
Q
F
W
R
Q
Q
V
Q
A
P
G
E
A
K
S
D
L
W
Q
-----------------
L
----------------
V
Q
F
S
R
R
F
KTEEVWP
E
D
L
L
A
K
K
PEL
R
-------
G
-
K
T
L
-------------
Y
EVLYATPEVSK-----------------
F
P
V
S
E
L
A
--------
E
D
Q
L
N
D
E
-
S
R
E
L
GFY
L
---------
Q
-----
K
G
-
L
F
---------------
E
--
E
-
Y
-
A
W
------
F
-
G
R
G
H
GHDLAP
F
D
D
Y
-----------------
H
K
A
R
--
G
L
---------
R
W
P
V
VNGKETQWRY
S
E
G
N
D
--------------
P
YVKA
G
---
E
G
----
Y
------------
K
-------
F
--------------------------
Y
G
K
P
D
G
K
A
V
I
F
A
L
P
-
F
E
-
P
A
A
--
E
--
A
P
D
E
E
Y
D
L
W
L
S
T
G
R
V
L
E
H
W
H
T
G
S
M
T
R
R
V
P
E
L
H
R
A
F
P
E
A
V
L
F
I
H
P
L
D
A
K
A
R
D
L
R
--
R
G
D
K
V
K
V
V
S
R
R
G
--
E
V
I
S
I
V
E
--
T
R
G
R
--
N
R
P
P
----
Q
G
L
V
Y
M
P
F
F
D
A
---
A
-
Q
L
V
N
K
L
T
------------
L
D
A
T
-
D
P
L
S
K
E
T
D
F
K
K
C
A
V
K
L
----------------------
11
PsiBlast_PDB
66.64
25%
-56
- C3 -
3ML1
5
NAPA_CUPNH
A:
[8-802]
-----------------------------------------------
E
V
T
K
L
K
W
S
K
A
P
C
R
F
C
G
T
G
C
G
V
----------
T
V
A
------------------------------------------
V
K
D
N
K
V
V
A
-
T
Q
G
-
D
P
QAE
V
N
K
--
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
Q
-----
D
-----
R
L
T
R
P
L
M
------
R
M
K
NGKYD
K
--
N
-------
G
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
G
M
----
F
----
G
S
----
G
Q
W
T
V
W
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
M
D
E
P
M
-
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-----
W
--
T
R
----------
V
T
D
R
---
R
------------
L
----------
S
--
H
-------
P
--
K
T
R
V
V
V
L
S
T
F
T
H
R
C
F
D
L
A
--------
D
--------
I
G
---
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
--
N
K
V
N
K
D
F
V
N
K
H
T
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
T
F
D
E
F
A
K
F
V
S
K
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
-
E
L
Y
-
A
D
P
N
------
I
-
K
------
V
-----
M
-
S
-
L
W
T
M
G
F
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
------------
G
N
S
P
F
S
L
T
-----------
G
Q
P
S
A
-
C
G
T
A
-
R
-
E
V
G
T
F
S
H
R
L
P
A
D
M
V
V
T
N
P
K
H
----
R
E
E
A
E
R
I
W
K
L
P
P
G
T
-
I
-
P
D
K
P
G
Y
D
A
V
L
Q
N
R
M
L
K
D
G
K
---
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
--
A
N
------------------------------
L
M
E
E
G
L
P
G
Y
R
N
----
P
--
A
-
N
-
F
I
V
-
V
S
D
A
Y
P
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
---
T
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
L
W
Q
L
V
E
F
A
K
R
F
KVEEVWP
P
E
L
----------------
I
A
-------------
K
K
P
E
Y
----
K
-------
G
-
K
T
L
-------------
Y
D
V
L
YRNGQVDKFPLKDVNAEYHN
A
E
A
K
A
F
G
F
Y
L
-
Q
--------
K
G
L
F
E
-
E
-
Y
A
T
----
F
---------
G
-----
R
G
-
H
G
---------------
H
--
D
-
L
-
A
P
------
F
D
A
Y
H
E
---------
A
-----------------
R
-----
G
L
---------
R
W
P
V
VNGKETRWRY
R
E
G
S
D
--------------
P
YVKA
G
---
T
G
----
F
------------
Q
-------
F
--------------------------
Y
G
N
P
D
G
K
A
V
I
F
A
L
P
-
Y
E
-
P
P
A
--
E
--
S
P
D
K
E
Y
P
Y
W
L
V
T
G
R
V
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
--
R
G
V
E
V
E
V
V
S
R
R
G
--
R
M
----
R
--
S
R
I
E
--
T
R
G
R
D
A
P
P
R
G
L
V
F
V
P
--
W
F
-
D
-
A
S
Q
L
I
N
K
V
T
------------
L
D
A
T
-
C
P
I
S
L
Q
T
D
F
K
K
C
A
V
K
I
V
K
V
-------------------
9
PsiBlast_PDB
65.63
26%
-55
- C3 -
1OGY
5
NAPA_RHOS4
A:
[19-799]
----------------------------------------------------------
C
R
F
C
G
T
G
C
G
V
M
V
G
--
T
R
DG
Q
V
V
A
------------------------------------------
T
H
G
D
T
Q
A
-------
E
---
V
N
R
--
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
E
-----
D
-----
R
L
T
T
P
L
L
------
R
MKDGVYH
K
--
E
-------
G
E
F
A
P
V
S
W
D
E
A
F
D
V
M
A
A
Q
A
K
L
V
L
K
E
K
A
P
E
A
V
G
M
----
F
----
G
S
----
G
Q
W
T
I
W
E
G
Y
A
A
S
K
L
M
R
A
G
F
R
S
N
N
L
D
P
N
-----
A
R
H
C
M
A
S
A
A
T
A
F
M
R
T
F
G
M
D
E
P
M
-
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-----
W
--
S
R
----------
L
--
T
---
D
------------
R
----------
R
--
L
-------
S
--
H
E
H
-
V
R
V
A
V
L
S
T
F
T
H
R
S
S
--------
D
--------
L
S
D
T
P
I
I
F
R
P
G
T
D
R
A
I
L
N
Y
I
A
H
H
I
I
S
T
--
G
R
V
N
R
D
F
V
D
R
H
T
N
F
A
L
G
ATDIGYGLRPEH
Q
L
Q
L
A
AKGAADAG
A
M
T
P
T
D
F
E
T
F
A
A
L
V
S
E
Y
T
L
E
K
A
A
E
I
S
G
V
E
P
A
L
L
E
E
L
A
-
E
L
Y
-
A
D
P
D
------
R
-
K
------
W
-----
M
-
S
-
L
W
T
M
G
F
N
Q
H
V
R
G
V
W
A
N
H
M
V
Y
N
L
H
L
L
T
G
K
I
S
E
P
------------
G
N
S
P
F
S
L
T
-----------
G
Q
P
F
A
-
C
G
T
A
-
R
-
E
V
G
T
F
A
H
R
L
P
A
D
M
V
V
T
N
P
E
H
----
R
A
H
A
E
E
I
W
K
L
P
A
G
L
-
L
-
P
D
W
V
G
A
H
A
V
E
Q
D
R
K
L
H
D
G
E
---
I
N
F
Y
W
V
Q
V
N
N
N
M
Q
A
A
P
N
I
D
------------------------------
Q
E
T
Y
P
G
----
Y
----
R
NP
E
-
N
-
F
I
V
-
V
S
D
A
Y
P
T
V
-
T
G
R
A
A
D
L
V
L
P
A
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
---
T
H
F
W
H
Q
L
V
E
A
P
G
E
A
R
S
D
L
W
Q
-----------------
L
M
E
F
S
K
R
FTTDEVWP
E
E
I
L
-------------
S
A
A
P
A
----
Y
R------
G
-
K
T
L
-------------
F
E
V
L
FANGSVDRFPASDVNPDHAN
H
E
A
A
L
F
G
F
Y
P
-
Q
--------
K
G
L
F
E
-
E
-
Y
A
A
----
F
---------
G
-----
R
G
-
H
G
---------------
H
--
D
-
L
-
A
P
------
F
D
T
Y
H
E
---------
V
-----------------
R
-----
G
L
---------
H
W
P
V
----------
V
E
G
E
E
TRWRYREGFDPYVK
P
----
G
---
E
G
----
L
------------
R
-------
F
--------------------------
Y
G
K
P
D
G
R
A
V
I
L
G
V
P
-
Y
E
-
P
P
A
--
E
--
S
P
D
E
E
F
G
F
W
L
V
T
G
R
V
L
E
H
W
H
S
G
S
M
T
L
R
W
P
E
L
Y
K
A
F
P
G
A
V
C
F
M
H
P
E
D
A
R
S
R
G
L
N
--
R
G
S
E
V
R
V
I
S
R
R
G
--
E
I
--
R
T
R
L
E
T
R
G
R
--
N
R
M
P
----
R
G
V
V
F
V
P
--
W
F
-
D
-
A
S
Q
L
I
N
K
V
T
------------
L
D
A
N
-
D
P
I
S
R
Q
T
D
F
K
K
C
A
V
K
I
----------------------
57
Fugue
63.56
25%
-65
- C3 -
2VPZ
4
?
A:
[30-763]
--------------------------------------------
A
P
W
Y
A
Q
E
V
K
S
V
Y
Q
I
C
E
G
C
F
W
R
C
G
I
V
A
H
A
V
G
---
N
R
V
Y
------------------------------------------
K
V
E
G
Y
E
-----
A
-
N
P
---
K
S
R
--
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
P
-----
D
-----
R
L
K
R
P
L
I
R
VEGSQ
R
-------
G
--
E
-------
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
----
F
----
G
H
----
G
---
T
G
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
S
-----
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
-
I
G
G
H
E
P
I
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
N
T
Q
-----
L
--
Q
D
----------
F
--
A
---
L
------------
A
----------
L
--
K
-------
N
--
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
--------
R
W
---
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
--
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------
G
F
E
E
L
K
A
H
V
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
-
R
E
M
-
A
A
-
H
------
K
-
P
------
R
-----
A
V
L
-
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
GGFY
I
A
Q
S
P
Y
L
E
K
Y
P
L
P
P
L
P
-----------
L
E
P
A
A
-
G
G
-
C
-
S
-
G
P
S
G
G
D
H
E
P
E
G
F
K
P
R
A
D
K
G
K
----
F
--
F
A
R
S
T
A
I
Q
------------
E
L
I
E
P
M
I
T
G
E
P
Y
P
---
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
------------------------------
R
T
K
E
A
L
----
K
----
N
--
L
-
D
-
L
Y
V
-
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
-
W
W
-----------------
I
----------------
A
R
-------------
E
L
G
L
R
----
L
-------
G
-
L
E
Q
-------------
Y
----------------------------
F
P
-------------
W
K
T
I
E
-
E
-
Y
L
E
----
T
---------
R
-------------------------
L
--
Q
-
S
-
L
G
------
L
-
D
L
E
T
---------
M
-----------------
K
G
M
G
--
T
L
V
Q
R
G
K
P
W
L
E
D
W
E
K
----------
E
G
R
L
P
--------------
F
----
G
---
T
A
----
S
------------
G
-------
K
----
I
---
E
-
L
---------------
Y
C
Q
R
F
K
E
A
G
-
H
Q
P
L
-
P
V
-
F
T
P
P
E
E
--
P
P
E
G
F
Y
R
L
L
Y
G
R
----
S
P
V
H
T
F
A
R
T
Q
N
N
W
V
L
M
E
M
D
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
--
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
G
--
P
V
R
--
V
K
P
T
--
A
R
I
R
----
K
D
C
V
Y
I
V
H
G
F
G
-
H
-
K
-
A
P
L
M
R
L
A
HGRGASDNYLQT
R
Y
K
L
-
D
P
I
S
G
G
A
G
L
R
V
N
F
V
R
L
E
K
A
E
R
P
R
L
P
S
L
T
G
L
A
K
R
P
F
D
ER
35
HHSearch
63.20
25%
-52
- C3 -
3ML1
5
NAPA_CUPNH
A:
[5-802]
-------------------------------------------
T
D
S
E
V
T
-
K
L
K
W
S
K
A
P
C
R
F
C
G
T
G
C
G
V
T
V
A
--
V
---
K
D
N
-------------------------------------------
K
V
V
A
T
Q
G
--
D
P
Q
-
A
E
---
V
N
K
--
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
Q
-----
D
-----
R
L
T
R
P
L
M
------
R
-------
M
--
K
NGKYDKN
G
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
G
M
----
F
----
G
S
----
G
Q
W
T
V
W
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
M
D
E
-
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-----
W
--
T
R
----------
V
--
T
---
D
------------
R
----------
R
L
-
S
H
------
P
--
K
T
R
V
V
V
L
S
T
F
T
H
R
C
F
D
L
A
--------
D
--------
I
G
---
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
NK
V
N
--
K
D
F
V
N
K
H
T
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
T
F
D
E
F
A
K
F
V
S
K
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
-
E
L
Y
-
A
D
-
P
------
N
I
K
------
V
-----
M
-
S
-
L
W
T
M
G
F
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
------------
G
N
S
P
F
S
L
T
-----------
G
Q
P
S
A
-
C
G
-
T
-
A
R
E
V
G
T
F
S
H
R
L
P
A
D
M
V
V
T
N
P
K
H
----
R
E
E
A
E
R
I
W
K
L
P
P
G
T
I
P
-
D
K
P
-
G
Y
D
A
V
L
Q
N
R
M
L
K
D
G
K
---
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
--------------------------------
L
M
E
E
G
L
----
P
G
Y
R
N
P
--
A
-
N
-
F
I
V
-
V
S
D
A
Y
P
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
E
R
R
---
T
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
-
L
W
-----------------
Q
----------------
L
V
-------------
E
F
A
K
R
----
F
-------
K
-
V
E
E
-------------
V
----------------------------
W
P
P
E
L
-
I
A
K
K
PEYKG
K
T
L
Y
D
-
V
-
L
Y
R
----
N
---------
G
QV---
D
K
-
F
P
LKDVNAEYHN
A
E
A
K
A
F
--
G
F
Y
L
Q
K
------
G
-
L
F
E
E
---------
Y
A
T
F
G
RGHGHDLAP
F
D
A
Y
H
E
A
R
--
G
L
---------
R
W
P
V
----------
V
N
G
K
E
--------------
T
----
R
WRY
R
E
GSDP
Y
------------
V
-------
K
AGTG
F
---
Q
-
F
---------------
Y
G
N
P
D
G
K
A
V
I
F
A
L
P
-
Y
---
E
P
P
A
E
--
S
P
D
K
E
Y
P
Y
W
L
V
T
G
R
V
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
--
R
G
V
E
V
E
V
V
S
R
R
G
--
R
M
--
R
S
R
--
I
E
T
R
GR
D
A
P
P
----
R
G
L
V
F
V
P
W
F
D
A
S
Q
-
L
-
I
N
K
V
T
L
D
------------
A
T
C
P
I
S
---
L
Q
T
D
F
K
K
C
A
V
K
I
V
K
V
-------------------
15
PsiBlast_PDB
62.95
26%
-64
- C3 -
2VPZ
4
?
A:
[35-695]
-------------------------------------------------
Q
E
V
K
S
V
Y
Q
I
C
E
G
C
F
W
R
C
G
---
I
--
V
---
A
H
A
V
------------------------------------------
G
N
R
V
Y
K
V
E
-
G
Y
E
A
N
P
---
K
S
R
--
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
P
-----
D
-----
R
L
K
R
P
L
I
------
R
VEGSQR-
G
--
E
-------
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
----
F
----
G
H
----
G
T
---
G
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
S
-----
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
I
G
G
H
E
P
I
-
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
N
T
Q
-----
L
--
Q
D
----------
F
--
A
---
L
------------
A
----------
L
--
K
-------
N
--
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
--------
R
W
---
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
--
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------
G
F
E
E
L
K
A
H
V
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
-
R
E
M
A
A
H
-
K
------
P
-
R
------
A
-----
V
-
L
-
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
------------
G
G
F
Y
I
A
Q
S
P
Y
L
E
K
YPLPPL
P
L
E
P
A
-
A
G
-
G
-
C
-
S
G
P
S
G
G
D
H
E
P
-----
E
G
F
K
P
----
R
A
D
K
G
K
F
F
A
----------
R
-
S
T
A
I
Q
E
L
I
E
P
M
I
T
G
E
PYP
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
------------------------------
R
T
K
E
A
L
----
K
----
N
--
L
-
D
-
L
Y
V
-
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
-
W
W
-----------------
I
----------------
A
R
-------------
E
L
G
L
R
----
L
-------
G
-
L
E
Q
-------------
Y
----------------------------
F
P
W
K
T
-
I
--------
E
E
-
Y
L
-
E
-
T
R
L
----
Q
---------
S
-----
L
G
L
D
L
---------------
E
--
T
-
M
-
K
G
------
M
---
G
T
---------
L
-----------------
V
Q
R
G
--
K
------------
P
W
----------
L
E
-
D
W
--------------
E
----
K
---
E
G
----
R
------------
L
P
F
GTASG
K
----
I
---
E
-
L
---------------
Y
C
Q
R
F
K
E
A
G
H
Q
P
L
P
-
V
F
-
T
P
-
P
E
E
--
P
P
E
G
F
Y
--
R
L
L
Y
G
R
S
P
V
H
--
T
F
A
R
T
Q
N
N
W
V
L
M
E
M
D
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
EG
D
Y
V
M
L
V
N
Q
D
G
V
K
--
E
G
--
P
V
R
--
V
K
P
T
--
A
R
I
R
----
K
D
C
V
Y
I
------------------------------------------------------------------------
14
PsiBlast_PDB
62.82
26%
-62
- C3 -
2VPY
4
?
A:
[35-695]
-------------------------------------------------
Q
E
V
K
S
V
Y
Q
I
C
E
G
C
F
W
R
C
G
---
I
--
V
---
A
H
A
V
------------------------------------------
G
N
R
V
Y
K
V
E
-
G
Y
E
A
N
P
---
K
S
R
--
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
P
-----
D
-----
R
L
K
R
P
L
I
------
R
VEGSQR-
G
--
E
-------
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
----
F
----
G
H
----
G
T
---
G
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
S
-----
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
I
G
G
H
E
P
I
-
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
N
T
Q
-----
L
--
Q
D
----------
F
--
A
---
L
------------
A
----------
L
--
K
-------
N
--
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
--------
R
W
---
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
--
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------
G
F
E
E
L
K
A
H
V
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
-
R
E
M
A
A
H
-
K
------
P
-
R
------
A
-----
V
-
L
-
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
------------
G
G
F
Y
I
A
Q
S
P
Y
L
E
K
YPLPPL
P
L
E
P
A
-
A
G
-
G
-
C
-
S
G
P
S
G
G
D
H
E
P
-----
E
G
F
K
P
----
R
A
D
K
G
K
F
F
A
----------
R
-
S
T
A
I
Q
E
L
I
E
P
M
I
T
G
E
PYP
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
------------------------------
R
T
K
E
A
L
----
K
----
N
--
L
-
D
-
L
Y
V
-
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
-
W
W
-----------------
I
----------------
A
R
-------------
E
L
G
L
R
----
L
-------
G
-
L
E
Q
-------------
Y
----------------------------
F
P
W
K
T
-
I
--------
E
E
-
Y
L
-
E
-
T
R
L
----
Q
---------
S
-----
L
G
L
D
L
---------------
E
--
T
-
M
-
K
G
------
M
---
G
T
---------
L
-----------------
V
Q
R
G
--
K
------------
P
W
----------
L
E
-
D
W
--------------
E
----
K
---
E
G
----
R
------------
L
P
F
GTASG
K
----
I
---
E
-
L
---------------
Y
C
Q
R
F
K
E
A
G
H
Q
P
L
P
-
V
F
-
T
P
-
P
E
E
--
P
P
E
G
F
Y
--
R
L
L
Y
G
R
S
P
V
H
--
T
F
A
R
T
Q
N
N
W
V
L
M
E
M
D
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
EG
D
Y
V
M
L
V
N
Q
D
G
V
K
--
E
G
--
P
V
R
--
V
K
P
T
--
A
R
I
R
----
K
D
C
V
Y
I
------------------------------------------------------------------------
13
PsiBlast_PDB
62.38
26%
-62
- C3 -
2VPX
4
?
A:
[35-695]
-------------------------------------------------
Q
E
V
K
S
V
Y
Q
I
C
E
G
C
F
W
R
C
G
---
I
--
V
---
A
H
A
V
------------------------------------------
G
N
R
V
Y
K
V
E
-
G
Y
E
A
N
P
---
K
S
R
--
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
P
-----
D
-----
R
L
K
R
P
L
I
------
R
VEGSQR-
G
--
E
-------
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
----
F
----
G
H
----
G
T
---
G
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
S
-----
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
I
G
G
H
E
P
I
-
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
N
T
Q
-----
L
--
Q
D
----------
F
--
A
---
L
------------
A
----------
L
--
K
-------
N
--
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
--------
R
W
---
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
--
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
----------------------------------
G
F
E
E
L
K
A
H
V
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
-
R
E
M
A
A
H
-
K
------
P
-
R
------
A
-----
V
-
L
-
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
------------
G
G
F
Y
I
A
Q
S
P
Y
L
E
K
YPLPPL
P
L
E
P
A
-
A
G
-
G
-
C
-
S
G
P
S
G
G
D
H
E
P
-----
E
G
F
K
P
----
R
A
D
K
G
K
F
F
A
----------
R
-
S
T
A
I
Q
E
L
I
E
P
M
I
T
G
E
PYP
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
------------------------------
R
T
K
E
A
L
----
K
----
N
--
L
-
D
-
L
Y
V
-
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
-
W
W
-----------------
I
----------------
A
R
-------------
E
L
G
L
R
----
L
-------
G
-
L
E
Q
-------------
Y
----------------------------
F
P
W
K
T
-
I
--------
E
E
-
Y
L
-
E
-
T
R
L
----
Q
---------
S
-----
L
G
L
D
L
---------------
E
--
T
-
M
-
K
G
------
M
---
G
T
---------
L
-----------------
V
Q
R
G
--
K
------------
P
W
----------
L
E
-
D
W
--------------
E
----
K
---
E
G
----
R
------------
L
P
F
GTASG
K
----
I
---
E
-
L
---------------
Y
C
Q
R
F
K
E
A
G
H
Q
P
L
P
-
V
F
-
T
P
-
P
E
E
--
P
P
E
G
F
Y
--
R
L
L
Y
G
R
S
P
V
H
--
T
F
A
R
T
Q
N
N
W
V
L
M
E
M
D
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
EG
D
Y
V
M
L
V
N
Q
D
G
V
K
--
E
G
--
P
V
R
--
V
K
P
T
--
A
R
I
R
----
K
D
C
V
Y
I
------------------------------------------------------------------------