@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03320: (2016-06-05 )
MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYNRILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSYDKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEAAVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATKADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVGECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQEDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKKQIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCGGCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLDWKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANIIEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQNRSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVRGTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFEEDLRAQLLESLQTDLSLIQNPTVETGAYKKG
Atome Classification :
(20 SA)
.........10........20........30--.....-...40........-50......-------..-------.--60.-.---------....-..70........80........90....-----.-----.-..100.......110....-.-..120---.-......130-.........140--.--......150.......160....----...170.......180.......190.......200.......210....---.-------------------..220....-...230.......240.......250...---....260.......270.......280..-------.------.------.------.------.290.......300...-....310.......320.......330......-----------------------------------.-----340---..--.-------.--------...--..350..---..--..--.360.......370.--.---.--.....380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
Q
R
L
V
L
AGNGM
A
G
I
R
C
I
E
E
V
L
K
LNR
H
M
F
E
--
I
V
I
FG-SEPHP
N
Y
N
R
I
L
L
S
-
S
-
V
LQGEA-------SL-------
D
--
D
I
T-L---------NSKD-WYDKH
G
I
T
L
YTG
E
T
V
I
Q
IDT
D
Q
Q
Q
V
I
T
D
-----
R
-----
K
-RTLSY
D
K
L
I
V
ATGSSP
H
I
L
-P-IPGAD---K-KGVYGFR---
T
I
E
D
C
Q
A
L
M
N
M
A
--
Q
--
H
F
Q
K
A
A
V
I
G
A
G
L
L
G
L
E
A
A
V
G
L
Q
H
----LG
M
D
V
S
V
IH
H
S
A
G
I
M
Q
K
Q
L
D
Q
T
A
A
R
L
L
Q
T
E
L
E
QKG
L
T
F
L
L
EK
D
T
V
SISGA---T-------------------KA
D
R
I
H
FKD-GSSL
K
A
D
L
I
V
M
AAGVKP
N
I
E
L
A
V
SAG
I
K
V---NR
G
I
I
V
N
D
F
MQTSEP
N
I
Y
A
V
G
ECAEHN
G
T
-------
V
------
Y
------
G
------
L
------
V
A
P
L
Y
EQ
G
K
A
L
A
S
H
ICG-V
P
C
E
E
YQGSAPS
A
A
L
K
I
A
G
I
D
VWSAGKIQEDER-----------------------------------T-----
T
-----
S
I
--
K
-------
I
--------YDE--QAG
V
Y
K
K
---
A
L
--
F
V--DDK
L
A
G
V
I
L
FGDT-
R
--
D
---
K
--
Q
R
L
L
D
S
L
L
K
QR
D
I
S
I
A
K
K
QIIEPETSGP
L
F
ESMPSSE
T
I
C
Q
CNTVTKG
A
I
EDAVHTNSLT
T
V
E
E
V
K
H
C
T
K
ATGSCGG
C
K
P
L
V
E
D
L
L
R
Y
MTNSEYTKPASTPS
F
C
SCTDFT
E
D
D
I
I
A
E
L
Q
RRPFT
N
P
A
E
V
M
N
Q
LDWKTKNG
C
S
T
C
V
P
A
I
Q
Y
Y
L
E
M
LYPGFVQPEPATEE
T
C
I
L
I
P
Q
MYGGRT
N
A
E
Q
L
R
T
I
A
N
I
I
E
A
YSIPD
V
S
ITHG
Q
R
L
KLSGIKPADLP
N
M
K
K
D
LKMPVY
T
N
E
H
R
H
A
L
Q
S
I
K
A
CTCGQNR
S
I
Q
Q
L
A
A
Q
I
E
R
Q
L
E
MLPLPA
P
I
S
I
S
L
SCET
D
C
T
E
A
A
L
Q
D
V
G
A
I
RTQAG
W
D
I
H
IGGVRGTHARS
G
A
L
F
C
V
TENED
S
T
A
G
M
I
K
G
L
I
Q
Y
Y
R
E
T
A
H
Y
L
E
G
V
H
Q
W
I
D
R
L
G
I
V
H
I
R
E
V
L
F
E
E
D
L
R
A
Q
L
L
E
S
L
Q
T
D
L
S
L
IQNPTVETGAYKKG
47
HHSearch
82.80
27%
-138
- C2 -
2V3A
9
RURE_PSEAE
A:
[4-369]
--
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
-
E
T
P
--
L
L
M
I
T
-
A
D
D
G
R
S
Y
S
K
P
M
L
S
-
T
-
G
F
S
K
N
K
-------
D
A
-------
D
--
G
L
A
M
A
---------
E
P
G
A
-
M
A
E
Q
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
-----------
E
-
E
E
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
-
P
-
V
E
G
D
A
---
Q
-
D
A
L
Y
P
I
N
---
D
L
E
D
Y
A
R
F
R
Q
A
A
--
A
--
G
K
R
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
----
G
G
Y
Q
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
---
G
-------------------
E
G
L
E
A
H
L
S
D
-
G
E
V
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
A
F
A
A
G
L
A
V
---
N
R
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
D
G
L
-------
N
------
L
------
L
------
Y
------
V
M
P
L
M
A
C
A
R
A
L
A
Q
T
L
A
G
-
N
P
-
S
Q
V
A
Y
G
P
M
P
V
T
V
K
T
P
A
C
P
L
V
V
S
P
P
P
R
G
M
D
------------------------------------
G
-----
Q
------
W
----------
L
--------
V
E
---
G
S
G
T
D
L
K
---
V
L
--
C
R
D
T
A
G
R
V
I
G
Y
A
L
T
G
A
A
-
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
82.30
21%
-127
- C2 -
3ICS
3
?
A:
[35-457]
-
G
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
S
E
-
E
D
E
--
I
I
M
V
E
-
R
G
E
Y
I
S
F
A
N
C
G
L
P
-
Y
-
Y
I
G
G
V
I
-------
T
E
RQ-----
K
--
L
L
V
-
Q
---------
T
V
E
R
-
M
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
T
I
T
I
K
-----
N
VTTN
E
T
-
Y
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
-
S
-
I
P
G
I
E
E--
A
-
K
A
L
F
T
L
R
---
N
V
P
D
T
D
R
I
K
A
Y
I
--
D
E
K
K
P
R
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
R
E
----
R
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
I
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
F
E
D
G
V
D
A
L
E
E
N
---
G
---------------------
A
V
V
R
L
K
S
-
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
L
A
L
GV-
R
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
VTE
T
E
T
-
M
------
I
------
P
------
L
------
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
-
H
T
D
S
L
Y
K
G
T
L
G
T
S
V
A
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
-----------------------------------
R
L
N
I
P
Y
E
-----
V
V
--
H
-------
V
Q
A
N
SHAGY
Y
P
N
--
A
T
P
V
L
I
K
---
L
I
--
F
N
KD
S
G
K
I
Y
G
A
Q
T
L
G
R
D
-
G
--
V
D
K
R
M
--
D
V
I
A
T
A
I
K
A
N
L
T
V
L
D
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
79.65
25%
-110
- C2 -
3NTD
2
?
A:
[1-441]
--
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
-
T
A
E
--
I
I
M
F
E
-
R
G
E
Y
V
S
F
A
N
C
G
L
P
-
Y
-
H
I
S
G
E
I
-------
A
Q
R
------
S
--
A
L
V
L
Q
---------
T
P
E
S
-
F
K
A
R
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
RLLDG
S
-----
E
-
Y
Q
E
S
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
P
-
P
-
I
P
G
V
D
---
N
-
P
L
T
H
S
L
R
---
N
I
P
D
M
D
R
I
L
Q
T
I
--
Q
MN
N
V
E
H
A
T
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
H
H
----
L
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
V
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
L
G
T
A
L
S
E
V
S
Y
Q
---
V
QT
H
V
A
S
DAAGEDTAHQHIK
G
H
L
S
L
T
L
S
N
-
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
L
A
I
GE-
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
-------
V
TG
Q
A
C
L
V
------
P
------
L
------
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
-
R
-
E
E
R
Y
Q
G
T
Q
G
T
A
I
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
K
Q
L
K
-----------------------------------
Q
-----
A
G
I
A
F
E
K
V
Y
-
V
HTASHAS
Y
--------
Y
P
G
--
A
E
V
V
S
F
K
---
L
L
--
F
D
PV
K
G
T
I
F
G
A
Q
A
V
G
K
D
-
G
--
I
D
K
-
R
I
-
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
77.63
28%
-128
- C2 -
1XHC
1
?
A:
[9-359]
---
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
L
S
Q
----
T
Y
E
--
V
T
V
I
D
-
K
E
P
V
P
Y
Y
S
K
P
M
L
S
-
H
-
Y
I
A
G
F
I
-------
P
R
-------
N
--
R
L
F
-
P
---------
Y
S
L
D
-
W
Y
R
K
R
G
I
E
I
R
L
A
E
E
A
K
L
I
D
R
G
R
K
V
V
I
T
E
-----------
K
-
G
E
V
P
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
P
-
Q
-
I
K
G
K
------
E
Y
L
L
T
L
R
---
T
I
F
D
A
D
R
I
K
E
S
I
--
E
--
N
S
G
E
A
I
I
I
G
G
G
F
I
G
L
E
L
A
G
N
L
A
E
----
A
G
Y
H
V
K
L
I
H
R
G
A
M
F
L
--
G
L
D
E
E
L
S
N
M
I
K
D
M
L
E
E
T
G
V
K
F
F
L
N
S
E
L
L
E
A
N
E
E
--------------------------
G
V
-
L
T
N
-
S
G
F
I
E
G
K
V
K
I
C
A
I
G
I
V
P
N
V
D
L
A
R
R
S
G
I
H
T
---
G
R
G
I
L
I
D
D
N
F
R
T
S
A
K
D
V
Y
A
I
G
D
C
A
E
Y
S
G
I
-------
I
------
A
------
G
------
T
------
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
G
-
E
-
P
R
R
Y
N
F
K
F
R
S
T
V
F
K
F
G
K
L
Q
I
A
I
I
G
N
T
K
G
E
G
K
---------------------------------------------------
W
-------
I
---------------
E
D
N
T
K
---
V
F
--
Y
-------
I
G
A
V
V
F
N
D
I
-
R
--
K
---
A
--
T
K
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.42
29%
-136
- C2 -
2V3A
9
RURE_PSEAE
A:
[4-316]
--
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
E
T
P
L
--
L
M
I
T
A
-
D
D
G
R
-
S
Y
S
K
P
M
L
S
-
T
-
G
F
S
K
N
K
-------
D
A
-------
D
--
G
L
A
-
M
---------
A
E
P
G
A
M
A
E
Q
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
-----
E
-----
E
-
E
-
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
-
P
-
V
E
G
D
A
---
Q
-
D
A
L
Y
P
I
N
---
D
L
E
D
Y
A
R
F
R
Q
A
A
--
A
--
G
K
R
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
----
G
G
Y
Q
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
---
G
-------------------
E
G
L
E
A
H
L
S
D
-
G
E
V
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
A
F
A
A
G
L
A
V
---
N
R
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
D
G
L
-------
N
------
L
------
L
------
Y
------
V
M
P
L
M
A
C
A
R
A
L
A
Q
T
L
A
G
-
N
P
S
Q
V
A
Y
G
P
M
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.02
26%
-128
- C2 -
3KLJ
1
NROR_CLOAB
A:
[8-356]
-
K
S
T
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
L
G
---
K
C
D
D
--
I
T
M
I
N
-
S
E
K
Y
L
P
Y
Y
R
P
R
L
N
-
E
-
I
I
A
K
N
K
-------
S
I
-------
D
--
D
I
L
-
I
---------
K
K
N
D
-
W
Y
E
K
N
N
I
K
V
I
T
S
E
F
A
T
S
I
D
P
N
N
K
L
V
T
L
K
-----
S
-----
G
-
E
K
I
K
Y
E
K
L
I
I
A
S
G
S
I
A
N
K
I
-
K
-
V
P
H
A
D
---
E
---
I
F
S
L
Y
---
S
Y
D
D
A
L
K
I
K
D
E
C
--
K
--
N
K
G
K
A
F
I
I
G
G
G
I
L
G
I
E
L
A
Q
A
I
I
D
----
S
G
T
P
A
S
I
G
I
I
L
E
Y
P
L
E
R
Q
L
D
R
D
G
G
L
F
L
K
D
K
L
D
R
L
G
I
K
I
Y
T
N
S
------------------------------------
N
F
E
E
M
G
D
L
I
R
S
S
C
V
I
T
A
V
G
V
K
P
N
L
D
F
I
K
D
T
E
I
A
S
---
K
R
G
I
L
V
N
D
H
M
E
T
S
I
K
D
I
Y
A
C
G
D
V
A
E
F
Y
G
K
-------
N
------
P
------
G
------
L
------
I
N
I
A
N
K
Q
G
E
V
A
G
L
N
A
C
G
-
E
D
A
-
S
Y
S
E
I
I
P
S
P
I
L
K
V
S
G
I
S
I
I
S
C
G
D
I
E
N
N
K
P
-----------------------------------
S
-----
K
-----
V
F
--
R
-----------------
S
T
--
Q
E
D
K
Y
I
V
---
C
M
--
L
K
--
E
N
K
I
D
A
A
A
V
I
G
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
75.81
25%
-126
- C2 -
1Q1R
1
CAMA_PSEPU
A:
[2-397]
N
A
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
W
-
E
G
N
--
I
R
L
V
G
-
D
A
T
V
I
P
H
H
L
P
P
L
S
K
A
-
Y
L
A
G
K
A
-------
T
A
-------
E
--
S
L
Y
-
L
---------
R
T
P
D
-
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
-----
D
-----
G
-
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
-
V
A
S
G
A
VGK
A
-
N
N
F
R
Y
L
R
---
T
L
E
D
A
E
C
I
R
R
Q
L
--
I
--
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
----
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
Q
V
C
G
F
E
M
S
TDQ
Q
-------------------
K
V
T
A
V
L
C
E
D
-
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
---
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
-------
L
------
Y
------
D
R
W
V
R
I
E
S
------
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
-
K
V
-
P
R
D
-
E
A
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
V
G
L
S
E
G
Y
-------------------------------------
D
-----
R
-----
I
I
--
V
-------
R
--------
G
S
L
--
A
Q
P
D
F
S
V
---
F
Y
--
L
Q
--
G
D
R
V
L
A
V
D
T
V
N
R
P
-
V
--
E
---
F
--
N
Q
S
K
Q
I
I
T
D
R
L
P
V
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.43
29%
-142
- C2 -
2V3B
1
RURE_PSEAE
A:
[4-316]
--
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
E
T
P
L
--
L
M
I
T
A
-
D
D
G
R
-
S
Y
S
K
P
M
L
S
-
T
-
G
F
S
K
N
K
-------
D
A
-------
D
--
G
L
A
-
M
---------
A
E
P
G
A
M
A
E
Q
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
-----
E
-----
E
-
E
-
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
-
P
-
V
E
G
D
A
---
Q
-
D
A
L
Y
P
I
N
---
D
L
E
D
Y
A
R
F
R
Q
A
A
--
A
--
G
K
R
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
----
G
G
Y
Q
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
---
G
-------------------
E
G
L
E
A
H
L
S
D
-
G
E
V
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
A
F
A
A
G
L
A
V
---
N
R
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
D
G
L
-------
N
------
L
------
L
------
Y
------
V
M
P
L
M
A
C
A
R
A
L
A
Q
T
L
A
G
-
N
P
S
Q
V
A
Y
G
P
M
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
75.42
25%
-128
* C2 *
3EF6
10
TODA_PSEP1
A:
[3-387]
---
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
F
-
E
G
R
--
I
S
L
I
G
-
D
E
P
H
L
P
Y
D
R
P
S
L
S
-
K
-
A
V
L
D
G
S
-------
L
E
-------
R
--
P
P
I
-
L
---------
A
E
A
D
-
W
Y
G
E
A
R
I
D
M
L
T
G
P
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
D
-----
D
-----
G
-
T
T
L
S
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
-
A
-
L
P
G
S
Q
---
L
-
P
G
V
V
T
L
R
---
T
Y
G
D
V
Q
V
L
R
D
S
W
--
T
--
S
A
T
R
L
L
I
V
G
G
G
L
I
G
C
E
V
A
T
T
A
R
K
----
L
G
L
S
V
T
I
L
E
A
G
D
E
L
L
V
R
V
L
G
R
R
I
G
A
W
L
R
G
L
L
T
E
L
G
V
Q
V
E
L
G
T
G
V
V
G
F
S
G
E
---
G
-------------------
Q
L
E
Q
V
M
A
S
D
-
G
R
S
F
V
A
D
S
A
L
I
C
V
G
A
E
P
A
D
Q
L
A
R
Q
A
G
L
A
C
---
D
R
G
V
I
V
D
H
C
G
A
T
L
A
K
G
V
F
A
V
G
D
V
A
S
W
P
L
R
A
G
G
R
R
--
S
------
L
------
E
------
T
------
Y
M
N
A
Q
R
Q
A
A
A
V
A
A
A
I
L
G
-
K
-
N
V
S
A
P
Q
-
L
P
V
S
W
T
E
I
A
G
H
R
M
Q
M
A
G
D
I
E
G
P
G
------------------------------------------
D
-----
F
V
--
S
-------
R
--------
G
M
----
P
G
S
G
A
A
---
L
L
F
R
L
Q
--
E
R
R
I
Q
A
V
V
A
V
D
A
P
-
R
--
D
---
F
--
A
L
A
T
R
L
V
E
A
R
A
A
I
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
74.12
22%
-125
- C2 -
3FG2
2
?
P:
[1-373]
--
N
D
T
V
L
I
A
G
A
G
H
A
G
F
Q
V
A
V
S
L
R
Q
A
K
Y
-
P
G
R
--
I
A
L
I
N
-
D
E
K
H
L
P
Y
Q
R
P
P
L
S
-
K
A
Y
L
K
S
G
G
-------
D
P
-------
N
--
S
L
M
-
F
---------
R
P
E
K
-
F
F
Q
D
Q
A
I
E
L
I
S
-
D
R
M
V
S
I
D
R
E
G
R
K
L
L
L
A
-----
S
-----
G
-
T
A
I
E
Y
G
H
L
V
L
A
T
G
A
R
N
R
M
L
-
D
-
V
P
N
A
S
---
L
-
P
D
V
L
Y
L
R
---
T
L
D
E
S
E
V
L
R
Q
R
M
--
P
--
D
K
K
H
V
V
V
I
G
A
G
F
I
G
L
E
F
A
A
T
A
R
A
----
K
G
L
E
V
D
V
V
E
L
A
P
R
V
M
A
R
V
V
T
P
E
I
S
S
Y
F
H
D
R
H
S
G
A
G
I
R
M
H
Y
G
V
R
A
T
E
I
A
A
E
G--
D
-------------------
R
V
T
G
V
V
L
S
D
-
G
N
T
L
P
C
D
L
V
V
V
G
V
G
V
I
P
N
V
E
I
A
A
A
A
G
L
P
T
---
A
A
G
I
I
V
D
Q
Q
L
L
T
S
D
P
H
I
S
A
I
G
D
C
A
L
F
E
S
V
-------
R
FGETMR
V
------
E
------
S
------
V
Q
N
A
T
D
Q
A
R
C
V
A
A
R
L
T
G
-
D
-
A
K
P
Y
D
G
Y
P
W
F
-
W
S
D
Q
G
D
D
K
L
Q
I
V
G
L
T
A
G
F
-------------------------------------
D
-----
Q
-----
V
V
--
I
-------
R
--------
G
S
V
--
A
E
R
S
F
S
A
---
F
C
--
Y
K
--
A
G
K
L
I
G
I
E
S
V
N
R
A
-
A
--
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
73.97
23%
-117
- C2 -
4EQS
6
CDR_STAA3
A:
[1-413]
---
P
K
I
V
V
V
G
A
V
A
G
G
A
T
C
A
S
Q
I
R
R
L
D
K
-
E
S
D
--
I
I
I
F
E
-
K
D
R
D
M
S
F
A
N
C
A
L
P
-
Y
-
V
I
G
E
V
V
-------
E
D
-------
R
RY
A
L
A
-
Y
---------
T
P
E
K
-
F
Y
D
R
K
Q
I
T
V
K
T
Y
H
E
V
I
A
I
N
D
E
R
Q
T
V
S
V
L
-----
N
RKTN
E
Q
-
F
E
E
S
Y
D
K
L
I
L
S
P
G
A
S
A
N
S
L
-
G
-
F
E
S
D
-------
I
T
F
T
L
R
---
N
L
E
D
T
D
A
I
D
Q
F
I
K
A
N
--
Q
V
D
K
V
L
V
V
G
A
G
Y
V
S
L
E
V
L
E
N
L
Y
E
----
R
G
L
H
P
T
L
I
H
R
S
D
K
I
N
K
-
L
M
D
A
D
M
N
Q
P
I
L
D
E
L
D
K
R
E
I
P
Y
R
L
N
E
E
I
N
A
I
N
G
N
--------------------------
E
I
T
F
K
S
-
G
K
V
E
H
Y
D
M
I
I
E
G
V
G
T
H
P
N
S
K
F
I
E
S
S
N
I
K
L
D
R-
K
G
F
I
P
V
N
D
K
F
E
T
N
V
P
N
I
Y
A
I
G
D
I
A
T
S
H
Y
R
-------
H
VD
L
P
A
S
V
------
P
------
L
------
A
W
G
A
H
R
A
A
S
I
V
A
E
Q
I
A
G
-
N
D
T
I
E
F
K
G
F
L
G
N
N
I
V
K
F
F
D
Y
T
F
A
S
V
G
V
K
P
N
E
L
K
-----------------------------------
Q
FD
Y
--
K
-----
M
V
E
V
T
-------
Q
GAHANY--
Y
P
G
--
N
S
P
L
H
L
R
---
V
Y
--
Y
D
TS
N
R
Q
I
L
R
A
A
A
V
G
K
E
G
A
D
K
R
---
I
--
D
V
L
S
M
A
M
M
N
Q
L
T
V
D
E
L
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
73.75
27%
-124
- C2 -
3KLJ
1
NROR_CLOAB
A:
[8-376]
-
K
S
T
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
L
G
K
---
C
D
D
--
I
T
M
I
N
-
S
E
K
Y
L
P
Y
Y
R
P
R
L
N
-
E
-
I
I
A
K
N
K
-------
S
I
-------
D
--
D
I
L
-
I
---------
K
K
N
D
-
W
Y
E
K
N
N
I
K
V
I
T
S
E
F
A
T
S
I
D
P
N
N
K
L
V
T
L
K
-----
S
-----
G
-
E
K
I
K
Y
E
K
L
I
I
A
S
G
S
I
A
N
K
I
-
K
-
V
P
H
A
------
D
E
I
F
S
L
Y
---
S
Y
D
D
A
L
K
I
K
D
E
C
--
K
--
N
K
G
K
A
F
I
I
G
G
G
I
L
G
I
E
L
A
Q
A
I
I
D
----
S
G
T
P
A
S
I
G
I
I
L
E
Y
P
L
E
R
Q
L
D
R
D
G
G
L
F
L
K
D
K
L
D
R
L
G
I
K
I
Y
T
N
S
N
F
E
E
M
------------------------------------
G
D
L
I
R
S
S
C
V
I
T
A
V
G
V
K
P
N
L
D
F
I
K
D
T
E
I
A
S
---
K
R
G
I
L
V
N
D
H
M
E
T
S
I
K
D
I
Y
A
C
G
D
V
A
E
F
Y
G
K
-------
N
------
P
------
G
------
L
------
I
N
I
A
N
K
Q
G
E
V
A
G
L
N
A
C
G
-
E
-
D
A
S
Y
S
E
I
I
P
S
P
I
L
K
V
S
G
I
S
I
I
S
C
G
D
I
E
N
N
K
------------------------------------------
P
-----
S
K
--
V
-------
F
--------
R
S
T
--
Q
E
D
K
Y
I
V
---
C
M
--
L
K
--
E
N
K
I
D
A
A
A
V
I
G
D
V
-
S
--
L
---
G
--
T
K
L
K
K
A
I
D
S
S
K
S
F
D
N
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
73.16
24%
-115
- C2 -
3LXD
1
?
A:
[8-399]
-
E
R
A
D
V
V
I
V
G
A
G
H
G
G
A
Q
A
A
I
A
L
R
Q
N
G
F
-
E
G
R
--
V
L
V
I
G
-
R
E
P
E
I
P
Y
E
R
P
P
L
S
K
E
-
Y
L
A
R
E
K
-------
T
F
-------
E
--
R
I
C
-
I
---------
R
P
A
Q
-
F
W
E
D
K
A
V
E
M
K
L
G
A
E
V
V
S
L
D
P
A
A
H
T
V
K
L
G
-----
D
-----
G
-
S
A
I
E
Y
G
K
L
I
W
A
T
G
G
D
P
R
R
L
-
S
-
C
V
G
A
D
---
L
-
A
G
V
H
A
V
R
---
T
K
E
D
A
D
R
L
M
A
E
L
--
D
A
-
G
A
K
N
A
V
V
I
G
G
G
Y
I
G
L
E
A
A
A
V
L
T
K
----
F
G
V
N
V
T
L
L
E
A
L
P
R
V
L
A
R
V
A
G
E
A
L
S
E
F
Y
Q
A
E
H
R
A
H
G
V
D
L
R
T
G
A
A
M
D
C
I
E
G
D
G--
T
-------------------
K
V
T
G
V
R
M
Q
D
-
G
S
V
I
P
A
D
I
V
I
V
G
I
G
I
V
P
C
V
G
A
L
I
S
A
G
A
S
G
---
G
N
G
V
D
V
D
E
F
C
R
T
S
L
T
D
V
Y
A
I
G
D
C
A
A
H
A
N
D
FADG
A
V
I
R
------
L
------
E
------
S
------
V
Q
N
A
N
D
M
A
T
A
A
A
K
D
I
C
G
-
A
-
P
V
P
Y
K
A
T
P
-
W
F
W
S
N
Q
Y
D
L
K
L
Q
T
V
G
L
S
T
G
H
-------------------------------------
D
-----
N
-----
A
V
--
L
-------
R
--------
G
D
P
--
A
T
R
S
F
S
V
---
V
Y
--
L
K
--
G
G
K
V
V
A
L
D
C
V
N
M
V
-
K
--
D
---
Y
--
V
Q
G
K
K
L
V
E
A
R
A
Q
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.39
30%
-144
- C2 -
1Q1W
1
CAMA_PSEPU
A:
[7-324]
-----
V
V
I
V
G
T
G
L
A
G
V
---
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
-
A
-
Y
L
A
G
K
A
-------
T
A
-------
E
--
S
L
Y
-
L
---------
R
T
P
D
-
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
-----
D
-----
G
-
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
-
V
A
S
G
A
---
V
-
G
K
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
--
I
--
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
----
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
Q
V
C
G
F
E
M
S
---
T
DQQ----------------
K
V
T
A
V
L
C
E
D
-
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
---
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
-------
L
------
Y
------
D
------
R
W
V
R
I
ES
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
P
R
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
72.34
21%
-114
- C2 -
1M6I
1
AIFM1_HUMAN
A:
[9-482]
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
-
G
A
R
--
V
L
I
V
S
-
E
D
P
E
L
P
Y
M
R
P
P
L
S
-
K
-
E
L
W
F
S
-PNVTKTL
R
F
KQWNG
K
E
R
--
S
I
Y
-
F
QPPSFYVSA
Q
D
L
P
-
H
I
E
N
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
-----
D
-----
G
-
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
-
S
A
I
D
R
A
G
A
E
-
V
K
S
R
T
T
L
F
R
---
K
I
G
D
F
R
S
L
E
K
I
S
--
R
--
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
---
S
-------------------
G
K
L
L
I
K
L
K
D
-
G
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
A
K
T
G
G
L
E
I
D
SD
F
G
G
F
R
V
N
A
E
L
Q
A
-
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
-------
K
L
G
R
R
R
-
V
------
E
------
H
------
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
-
A
-
A
K
P
Y
W
H
Q
S
M
F
W
S
D
L
G
P
D
V
G
Y
E
A
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
AQDN
P
K
S
A
T
E
Q
S
GTGI
R
S
E
S
E
TESEA
S
-----------------------------------------
Y
G
K
G
V
I
F
Y
--
L
R
--
D
K
V
V
V
G
I
V
L
W
N
I
F
-
N
--
R
---
M
--
P
I
A
R
K
I
I
K
D
G
E
Q
H
E
D
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
71.47
24%
-109
- C2 -
4FX9
3
CDR_PYRHO
A:
[5-420]
-
M
K
K
K
V
V
I
I
G
G
G
A
A
G
M
S
A
A
S
R
V
K
R
L
K
P
-
E
W
D
--
V
K
V
F
E
-
A
T
E
W
V
S
H
A
P
C
G
I
P
-
Y
-
V
V
E
G
L
S
-------
T
P
-------
D
--
K
L
M
-
Y
Y--------
P
P
E
V
-
F
I
K
K
R
G
I
D
L
H
L
N
A
E
V
I
E
V
D
T
G
Y
V
R
V
R
-------
G
-----
G
E
K
S
Y
E
W
D
Y
L
V
F
A
N
G
A
S
P
Q
V
P
-
A
-
I
E
G
V
N
---
L
-
K
G
V
F
T
A
D
---
L
P
P
D
A
L
A
I
R
E
Y
M
--
E
K
Y
K
V
E
N
V
V
I
I
G
G
G
Y
I
G
I
E
M
A
E
A
F
A
A
----
Q
G
K
N
V
T
M
I
V
R
G
E
R
V
L
R
R
S
F
D
K
E
V
T
D
I
L
E
E
K
L
K
K
-
H
V
N
L
R
L
Q
E
I
T
M
K
I
E
G
E
---
E
-------------------
R
V
E
K
V
-
V
T
D
-
A
G
E
Y
K
A
E
L
V
I
L
A
T
G
I
K
P
N
I
E
L
A
K
Q
L
G
V
R
I
GE-
T
G
A
I
W
T
N
E
K
M
Q
T
S
V
E
N
V
Y
A
A
G
D
V
A
E
T
R
H
V
-------
I
TG
R
R
V
W
V
------
P
------
L
------
A
P
A
G
N
K
M
G
Y
V
A
G
S
N
I
A
G
-
K
-
E
L
H
F
P
G
V
L
G
T
A
V
T
K
F
M
D
V
E
I
G
K
T
G
L
T
E
M
E
A
L
-----------------------------------
K
-----
E
GYD
V
R
T
A
--
F
-------
I
K
A
S
TRPHY
Y
P
G
--
G
R
E
I
W
L
K
---
G
V
--
V
D
NE
T
N
R
L
L
G
V
Q
V
V
G
S
D
-
I
--
L
---
P
R
I
D
T
A
A
A
M
L
M
A
G
F
T
T
K
D
A
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.09
30%
-145
- C2 -
1Q1R
1
CAMA_PSEPU
A:
[7-324]
-----
V
V
I
V
G
T
G
L
A
G
V
---
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
-
A
-
Y
L
A
G
K
A
-------
T
A
-------
E
--
S
L
Y
-
L
---------
R
T
P
D
-
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
-----
D
-----
G
-
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
-
V
A
S
G
A
---
V
-
G
K
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
--
I
--
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
----
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
Q
V
C
G
F
E
M
S
---
T
DQQ----------------
K
V
T
A
V
L
C
E
D
-
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
---
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
-------
L
------
Y
------
D
------
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
P
R
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.44
30%
-144
- C2 -
3LB8
1
CAMA_PSEPU
A:
[6-323]
-----
V
V
I
V
G
T
G
L
A
G
V
---
E
V
A
F
G
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
L
S
K
-
A
-
Y
L
A
G
K
A
-------
T
A
-------
E
--
S
L
Y
-
L
---------
R
T
P
D
-
A
Y
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
L
S
-----
D
-----
G
-
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
-
P
-
V
A
S
G
A
---
V
-
G
K
A
N
N
F
R
Y
L
R
T
L
E
D
A
E
C
I
R
R
Q
L
--
I
--
A
D
N
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
----
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
Q
V
C
G
F
E
M
S
---
T
DQQ----------------
K
V
T
A
V
L
C
E
D
-
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
A
G
L
Q
V
---
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
-------
L
------
Y
------
D
------
R
W
V
R
I
ES
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
V
P
R
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
69.87
24%
-115
- C2 -
2GQW
7
?
A:
[6-387]
-
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
-
Q
G
L
--
I
T
V
V
G
-
D
E
A
E
R
P
Y
D
R
P
P
L
S
-
K
-
D
F
M
A
H
G
-------
D
A
-------
E
--
K
I
R
-
L
------------
D
-
C
K
R
A
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
-----
D
-----
G
-
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
-
L
Q
G
A
T
-----
M
P
V
H
T
L
R
---
T
L
E
D
A
R
R
I
Q
A
G
L
--
R
--
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
----
A
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
--------------------------
G
V
V
L
L
D
D
-
G
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
R
A
A
G
L
A
C
---
D
D
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
-------
L
------
S
GRFERI
E
------
T
------
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
-
P
T
A
P
G
Y
A
E
-
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
S
G
D
E
------------------------------------------------
E
I
--
V
-------
R
--------
G
E
V
SL
D
A
P
K
F
T
L
---
I
E
--
L
Q
--
K
G
R
I
V
G
A
T
C
V
N
N
A
-
R
--
D
---
F
--
A
P
L
R
R
L
L
A
V
G
A
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.75
28%
-115
- C2 -
1XHC
1
?
A:
[10-359]
----
K
V
V
I
V
G
N
G
P
G
G
F
----
E
L
A
K
Q
L
S
Q
T
Y
E
--
V
T
V
I
D
-
K
E
P
V
P
Y
Y
S
K
P
M
L
S
-
H
-
Y
I
A
G
F
I
-------
P
R
-------
N
--
R
L
F
-
P
---------
Y
S
L
D
-
W
Y
R
K
R
G
I
E
I
R
L
A
E
E
A
K
L
I
D
R
G
R
K
V
V
I
T
E
-----------
K
-
G
E
V
P
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
P
-
Q
-
I
K
G
-----
K
-
E
Y
L
L
T
L
R
---
T
I
F
D
A
D
R
I
K
E
S
I
--
E
--
N
S
G
E
A
I
I
I
G
G
G
F
I
G
L
E
L
A
G
N
L
A
E
----
A
G
Y
H
V
K
L
I
H
R
G
A
--
M
F
L
G
L
D
E
E
L
S
N
M
I
K
D
M
L
E
E
T
G
V
K
F
F
L
N
S
E
L
L
E
A
N
E
E
---
G
-------------------
V
L
T
N
S
G
F
I
E
-
G
K
-----
V
K
I
C
A
I
G
I
V
P
N
V
D
L
A
R
R
S
G
I
H
T
---
G
R
G
I
L
I
D
D
N
F
R
T
S
A
K
D
V
Y
A
I
G
D
C
A
E
Y
S
G
I
-------
I
------
A
------
G
------
T
------
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
G
-
E
P
-
R
R
Y
N
F
K
F
R
S
T
V
F
K
F
G
K
L
Q
I
A
I
I
G
N
T
K
G
E
G
K
-----------------------------------
W
-----------------------
I
--------
E
D
N
--
T
-----
K
---
V
F
--
Y
-------
I
G
A
V
V
F
N
D
I
-
R
--
K
---
A
--
T
K
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------