@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03330: (2016-06-05 )
MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFGLSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSLTELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLAEQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLYSVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTKVLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMVTGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSWSAESSPADV
Atome Classification :
(20 SA)
-------------------.........10..---......20-----........30........-40--.----..--------------.....50........60........70........80...---.....---90-.......---.----.---100------......----..110...-----...-----.-120.-.....----.130.......140-------------.-..-....-..--150......--..160----------------------.--------------------------.--------------......-------------.170-.---....----...180..--------.....190-------.----..----------.-----.-----.--------------------------------.-------------------------.----------200-----......----.210.......220.-----.-----.....230.......-240-.-....---.----------...250.......260.......270.......280.---......290--..-------.------.---------.---..-----300--......-...-310....-...320.....-----------------.-.----------------------330.-....-..340....-...350.......360.......370.......380.......390.....---..400-------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------M
K
L
S
E
LKTSG
H
P
L
---
T
L
L
C
S
F
L
Y
-----
F
D
V
S
F
M
I
W
V
M
L
G
A
L
G
V
Y
I-SQ--D----FG--------------L
S
P
F
EK
G
L
V
V
A
V
PILSG
S
V
F
R
I
I
L
G
I
L
TDRIGP
K
K
T
A
V
I
G
---
M
L
V
T
M
---
I
--
P
L
L
W
GTF---G----G---
R
S
-------
L
T
E
L
Y
A
----
I
G
I
L
L
GVA-----GA
S
-----
F
-
A
V
AL-PMASR----WYPP
H
L
Q
G
L
A
M
G---------------I-AG-AGNS-
G
T
--
L
-
F
A
TLF
G
P
--
R
L
A
------------------------
E
--------------------------
Q
--------------FG
W
H
I
V
-------------
M
G
I
--
A
---
L
I
P
L
----
L
I
V
F
I
L
F
V
--------
S
MAKDSP--------A----QP----------S-----
P
-----
Q
--------------------------------
P
-------------------------
L
----------
K
S
Y
-----
L
H
V
FGQ----K
E
T
W
F
F
C
L
L
Y
S
VTF
G
-----
G
-----
F
V
G
L
S
S
F
L
S
I
F
FVDQ-
Y
---
Q
-
L
S
KI---H----------AG
D
F
V
T
L
C
V
AAG
S
F
F
R
P
V
G
G
L
I
SDRVG
G
T
K
V
L
S
V
L
F
V
---
I
V
A
L
C
M
A
G
V
--
S
S-------L------
P
---------
S
---
L
S
-----
M
----
V
I
V
L
L
F
-
V
G
M
-
M
GLGMGN-
G
A
V
F
Q
L
V
P
Q
R
F
-----------------
R
-
K
----------------------
E
IG
M
-
V
T
G
I
-
V
GAAGGI
G
G
-
F
F
L
P
N
I
L
G
S
L
K
Q
M
TG
T
Y
A
I
G
F
I
T
F
S
C
I
A
L
L
A
F
A
L
V
L
A
A
G
Y
Y
WRKSWSAESS---PADV--------------------------------------------------
32
HHSearch
79.68
26%
-172
- C3 -
4U4V
7
NARK_ECOLI
A:
[55-455]
----------------------------------------------------------
F
S
A
V
A
V
N
L
P
K
V
--
G
----
F
N
--------------
F
T
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
F
G
G
R
R
W
T
A
F
S
---
T
G
I
L
I
---
I
--
P
C
V
W
L
G
F
---
A
V
Q
D
T
S
---
T
P
-------
Y
S
V
F
I
I
----
I
S
L
L
C
G
F
A
-----
G
A
N
-----
F
-
A
S
S
M
-
A
N
I
S
F
----
F
F
P
K
Q
K
Q
G
G
A
L
G
---------------
L
-
N
G
G
L
G
N
M
-
G
V
--
S
-
V
M
Q
L
V
A
P
--
L
V
V
------------------------
S
--------------------------
L
SIFAV---------
F
G
S
Q
G
V
K
Q
PDGTELY
L
A
N
A
S
W
I
--
W
---
V
P
F
L
----
A
I
F
T
I
A
A
W
--------
F
G
M
N
D
L
A
--------
T
----------------------------------------------------------------------------------------------------------
L
P
V
L
K
R
----
G
H
L
W
I
M
S
L
L
Y
L
A
T
F
G
-----
S
-----
F
I
G
F
S
A
G
F
A
M
L
S
K
---
T
---
Q
-
F
P
D
V
---
Q
----------
I
L
Q
Y
A
F
F
G
P
F
I
G
A
L
A
R
S
A
G
G
A
L
S
D
R
L
G
G
T
R
V
T
L
V
N
F
I
---
L
M
A
I
F
S
G
L
L
--
F
L
-------
T
L-----
P
TDQGG----
S
---
F
M
-----
A
F
F
A
V
F
L
A
L
F
L
-
T
A
G
-
L
G
S
G
S
T
F
-
Q
M
I
S
V
I
F
R
K
L
T
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
-
A
T
---------------------
D
T
A
A
-
A
L
G
F
-
I
S
A
I
G
A
I
G
G
-
F
F
I
P
K
A
F
G
S
S
L
A
L
T
G
S
P
V
G
A
M
K
V
F
L
I
F
Y
I
A
C
V
V
I
T
W
A
-----------------------------------------------------------------------
2
PsiBlast_PDB
74.33
24%
-161
- C3 -
4U4V
7
NARK_ECOLI
A:
[47-463]
--------------------------------------------------
L
A
F
C
V
W
M
L
F
S
A
V
A
V
N
L
-
P
K
V-
G
----
F
N
--------------
F
T
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
F
G
G
R
R
W
T
A
F
S
---
T
G
I
L
I
---
I
--
P
C
V
W
L
G
F
---
A
----
V
---
Q
D
-------
T
S
T
P
Y
S
V
F
I
I
I
S
L
L
C
G
F
A
-----
G
A
N
-----
F
-
A
S
S
M
-
A
N
I
S
F
----
F
F
P
K
Q
K
Q
G
G
A
L
G
L
N
G
G
L
G
N
M
G
V
S
V
M
Q
L
V
-
A
P
-
L
V
V
S
-
L
S
--
I
-
F
A
V
F
G
S
Q
--
G
V
K
------------------------
Q
--------------------------
P
--------------
D
G
T
E
L
Y
-------------
L
A
N
--
A
S
WI
W
V
P
F
----
L
A
I
F
T
I
A
A
--------
W
F
G
M
N
D
L
--------
A
----
T
-----------------------------------------------------------------------------------------------------
L
P
V
L
K
R
----
G
H
L
W
I
M
S
L
L
Y
L
A
T
F
G
-----
S
-----
F
I
G
F
S
A
G
F
A
M
--
L
S
K
-
T
---
Q
-
F
P
D
V
---
Q
----------
I
L
Q
Y
A
F
F
G
P
F
I
G
A
L
A
R
S
A
G
G
A
L
S
D
R
L
G
G
T
R
V
T
L
V
N
F
I
---
L
M
A
I
-
F
S
G
L
L
F
L
T
-------
L
------
P
---------
T
---
D
-QGGS
F
M
----
A
F
F
A
V
F
-
L
A
L
F
L
T
A
G
L
G
S
-
G
S
T
F
Q
M
I
S
V
I
F
-----------------
R
-
K
L
T
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
A
T
D
T
A
A
-
A
L
G
F
-
I
S
A
I
G
A
I
G
G
-
F
F
I
P
K
A
F
G
S
S
L
A
L
T
G
S
-
P
V
G
A
M
K
V
F
L
I
F
Y
I
A
-
C
V
V
I
T
W
A
V
Y
G
R
H
S
K
K
-------------------------------------------------------------
21
Fugue
74.14
22%
-164
- C3 -
4IU9
-
NARU_ECOLI
A:
[12-454]
------------LLRDWKP
E
N
P
A
F
W
E
N
K
G
K
H
I
A
R
R
N
L
W
I
S
V
S
C
-----
L
L
L
A
F
C
V
W
M
L
F
S
A
V
T
V
N
L
-
N
K
I-
G
----
F
N
--------------
F
T
T
D
Q
L
F
L
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
F
G
G
R
R
W
T
V
F
S
---
T
A
I
L
I
---
I
--
P
C
V
W
L
G
I
---
A
V
Q
N
P
N
---
T
P
-------
F
G
I
F
I
V
----
I
A
L
L
C
G
F
A
-----
G
A
N
-----
F
-
A
S
S
M
-
G
N
I
S
F
----
F
F
P
K
A
K
Q
G
S
A
L
G
---------------
I
N
G
G
-
L
G
N
L
-
G
V
--
S
-
V
M
Q
L
V
A
P
--
L
V
I
------------------------
F
--------------------------
V
--------------
P
V
F
A
F
L
-------------
G
V
N
--
G
---
V
P
Q
A
----
D
G
S
V
M
S
L
A
--------
N
A
A
W
I
W
V
--------
P
----
L
L
----------
A
-----
I
-----
A
--------------------------------
T
-------------------------
I
----------
A
A
W
-----
S
G
M
-
N
D
----
I
A
L
W
L
L
S
L
L
Y
L
A
T
F
G
-----
S
-----
F
I
G
F
S
A
G
F
A
M
L
A
K
T
Q
-
F
------
P
D
V
---
N
----------
I
L
R
L
A
F
F
G
P
F
I
G
A
I
A
R
S
V
G
G
A
I
S
D
K
F
G
G
V
R
V
T
L
I
N
F
I
---
F
M
A
I
F
S
A
L
L
--
F
L
-------
T
L
P
G
T
G
S
G
---------
N
---
F
I
-----
A
----
F
Y
A
V
F
M
-
G
L
F
-
L
T
A
G
L
G
S
-
G
S
T
F
Q
M
I
A
V
-------------------------------------------------
I
L
G
F
-
I
S
A
I
G
A
V
G
G
-
F
F
I
P
Q
A
F
G
M
S
L
N
M
T
G
S
P
------
V
G
A
M
K
V
F
L
I
F
Y
I
V
C
V
L
L
T
W
L
V
Y
---------------------------------------------------------------
3
PsiBlast_PDB
73.15
24%
-156
- C3 -
4U4W
12
NARK_ECOLI
A:
[47-457]
--------------------------------------------------
L
A
F
C
V
W
M
L
F
S
A
V
A
V
N
L
-
P
K
V-
G
----
F
N
--------------
F
T
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
F
G
G
R
R
W
T
A
F
S
---
T
G
I
L
I
---
I
--
P
C
V
W
L
G
F
---
A
----
V
---
Q
D
-------
T
S
T
P
Y
S
V
F
I
I
I
S
L
L
C
G
F
A
-----
G
A
N
-----
F
-
A
S
S
M
-
A
N
I
S
F
----
F
F
P
K
Q
K
Q
G
G
A
L
G
L
N
G
G
L
G
N
M
G
V
S
V
M
Q
L
V
-
A
P
-
L
V
V
S
-
L
S
--
I
-
F
A
V
F
G
S
Q
--
G
V
K
------------------------
Q
--------------------------
P
--------------
D
G
T
E
L
Y
-------------
L
A
N
--
A
S
W
I
W
V
P
F
----
L
A
I
F
T
I
A
A
--------
W
F
G
M
N
D
L
--------
A
----
T
-----------
S
-----
K
-----
A
---------------------------------------------------------------------------------
K
R
----
G
H
L
W
I
M
S
L
L
Y
L
A
T
F
G
-----
S
-----
F
I
G
F
S
A
G
F
A
M
--
L
S
K
-
T
---
Q
-
F
P
D
V
---
Q
----------
I
L
Q
Y
A
F
F
G
P
F
I
G
A
L
A
R
S
A
G
G
A
L
S
D
R
L
G
G
T
R
V
T
L
V
N
F
I
---
L
M
A
I
-
F
S
G
L
LF
L
T
-------
L
------
P
---------
T
---
D
G
QGGS
F
M
----
A
F
F
A
V
F
-
L
A
L
F
L
T
A
G
L
G
S
-
G
S
T
F
Q
M
I
S
V
I
F
-----------------
R
-
K
L
T
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
A
T
D
T
A
A
-
A
L
G
F
-
I
S
A
I
G
A
I
G
G
-
F
F
I
P
K
A
F
G
S
S
L
A
L
T
G
S
-
P
V
G
A
M
K
V
F
L
I
F
Y
I
A
-
C
V
V
I
T
W
A
V
Y
-------------------------------------------------------------------
1
PsiBlast_PDB
70.60
24%
-166
- C3 -
4U4T
9
NARK_ECOLI
A:
[47-464]
--------------------------------------------------
L
A
F
C
V
W
M
L
F
S
A
V
A
V
N
L
-
P
K
V-
G
----
F
N
--------------
F
T
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
F
G
G
R
R
W
T
A
F
S
---
T
G
I
L
I
---
I
--
P
C
V
W
L
G
F
---
A
----
V
---
Q
D
-------
T
S
T
P
Y
S
V
F
I
I
I
S
L
L
C
G
F
A
-----
G
A
N
-----
F
-
A
S
S
M
-
A
N
I
S
F
----
F
F
P
K
Q
K
Q
G
G
A
L
G
L
N
G
G
L
G
N
M
G
V
S
V
M
Q
L
V
-
A
P
-
L
V
V
S
-
L
S
--
I
-
F
A
V
F
G
S
Q
--
G
V
K
------------------------
Q
--------------------------
P
--------------
D
G
T
E
L
Y
-------------
L
A
N
--
A
S
WI
W
V
P
F
----
L
A
I
F
T
I
A
A
--------
W
F
G
M
N
D
L
--------
A
----
T
-----------------------------------------------------------------------------------------------
Q
-----
L
P
V
L
K
R
----
G
H
L
W
I
M
S
L
L
Y
L
A
T
F
G
-----
S
-----
F
I
G
F
S
A
G
F
A
M
--
L
S
K
-
T
---
Q
-
F
P
D
V
---
Q
----------
I
L
Q
Y
A
F
F
G
P
F
I
G
A
L
A
R
S
A
G
G
A
L
S
D
R
L
G
G
T
R
V
T
L
V
N
F
I
---
L
M
A
I
-
F
S
G
L
LF
L
T
-------
L
------
P
---------
T
---
D
G
QGGS
F
M
----
A
F
F
A
V
F
-
L
A
L
F
L
T
A
G
L
G
S
-
G
S
T
F
Q
M
I
S
V
I
F
-----------------
R
-
K
L
T
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
A
T
D
T
A
A
-
A
L
G
F
-
I
S
A
I
G
A
I
G
G
-
F
F
I
P
K
A
F
G
S
S
L
A
L
T
G
S
-
P
V
G
A
M
K
V
F
L
I
F
Y
I
A
-
C
V
V
I
T
W
A
V
Y
G
R
H
S
K
K
L
------------------------------------------------------------
25
Fugue
69.75
16%
-190
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[22-435]
-------------------------
R
S
Y
I
I
P
F
---
A
L
L
C
S
L
F
F
-----
L
W
A
--
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
--
A
----
F
T
--------------
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
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I
L
M
K
K
L
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Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
---
L
G
A
A
L
F
W
P
A
A
---
E
----
I
---
M
N
-------
Y
T
L
F
L
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----
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L
F
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A
A
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-----
L
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C
-----
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-
E
T
A
A
N
P
F
V
T
V
----
L
G
P
E
S
S
G
H
F
R
L
N
---------------
L
-
A
Q
-
T
F
N
S
F
G
A
--
I
-
I
A
V
V
F
G
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--
S
L
I
LSNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
--------------------------
S
--------------
L
V
L
S
V
Q
-------------
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Y
--
M
---
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A
----
I
V
L
L
V
A
L
L
--------
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D
----
A
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----------
A
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L
-----
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R
L
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----
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W
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V
L
A
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L
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G
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A
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---
F
----------
A
A
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Y
L
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T
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V
C
F
F
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R
F
T
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W
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V
L
A
A
Y
A
L
---
I
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M
A
L
C
L
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--
A
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-------
A
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---------
G
---
H
V
-----
G
----
L
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A
L
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L
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A
-
F
-
M
S
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T
I
F
S
L
G
I
K
N
L
-----------------
G
-
Q
----------------------
D
T
K
Y
-
G
S
S
F
-
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V
M
T
I
-
I
G
G
-
G
I
V
T
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V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
----
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
---------------------------------------------------------------
26
Fugue
64.04
20%
-150
- C3 -
3WDO
-
?
A:
[3-455]
---------------------
D
Y
K
M
T
P
G
E
R
R
A
---
T
W
G
L
G
T
V
F
-----
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
-
M
A
--
L
----
Q
G
--------------
A
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A
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I
A
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G
I
Y
G
L
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Q
A
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Q
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L
L
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L
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L
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----
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A
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L
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----
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R
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K
A
M
A
---------------
F
-
I
G
-
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S
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G
-
I
T
--
F
A
I
A
M
V
L
G
P
--
I
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T
------------------------
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--------------------------
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--------------
L
G
L
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A
L
-------------
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W
M
--
I
---
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L
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----
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T
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I
A
L
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--------
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V
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--------
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H
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----------
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G
-----
M
--------------------------------
V
-------------------------
K
----------
G
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----------
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L
L
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L
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F
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-----
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M
C
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M
L
L
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A
L
P
-
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---
Q
-
L
A
D
A
GFP
A
----------
A
E
H
W
K
V
Y
L
A
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M
L
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A
F
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V
V
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I
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-------
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---
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-----
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----
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Q
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V
-
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V
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F
-
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L
M
E
A
L
L
P
S
L
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-----------------
S
-
K
----------------------
E
S
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A
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G
T
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A
M
G
V
Y
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A
I
G
G
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L
G
G
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L
A
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A
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L
A
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A
L
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R
L
L
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TEGVK
E
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L
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AEEEH
S
A
Y
V
K
I
DSKVTN
R
F
E
V
E
Q
A
I
R
QAL
43
HHSearch
63.43
16%
-161
- C3 -
4J05
1
?
A:
[43-508]
------------------------------------------
G
-----
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
-
A
Q
--
V
YFPK
T
G
--------------
L
P
A
Q
R
Q
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L
M
K
A
A
A
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I
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C
V
V
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G
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L
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D
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F
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R
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F
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Y
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K
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---
L
I
L
I
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---
V
--
A
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---
A
--------
P
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HWD
G
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----
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G
G
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----
R
A
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I
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R
R
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T
L
L
C
---------------
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-
I
F
A
N
Q
G
W
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G
S
--
F
-
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G
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V
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--------------------------
G
F
K
H
RLKSGHTHD
V
D
K
A
W
R
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L
-------------
I
G
L
--
S
---
L
I
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A
----
F
G
T
L
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Q
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R
-----------------------------------------------------------------------------------------------------------------------------WQE
F
-
V
A
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R
N
L
L
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M
L
G
W
F
L
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I
-----
A
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F
Y
G
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I
---
G
-
F
A
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Y
D
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L
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A
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L
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L
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M
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M
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L
F
L
A
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L
--
A
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------
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------
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---------
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K
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-----
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----
L
L
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F
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F
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A
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T
T
T
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A
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P
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R---------------------
I
R
A
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A
H
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A
A
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C
G
A
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L
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L
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A
K
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S
A
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L
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T
C
I
L
G
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I
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T
F
L
I
D
E
T
M
G
V
D
---------------------------------------------------------------
37
HHSearch
63.25
18%
-169
* C3 *
4LDS
-
?
A:
[7-413]
-------------------------------
L
---
I
F
I
L
G
A
L
G
-----
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
-
H
K
--
D
----
I
P
--------------
L
N
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T
T
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I
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M
L
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A
I
V
G
A
G
S
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P
L
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L
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R
R
R
L
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M
L
I
---
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A
A
---
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--------
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N
-------
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A
L
L
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I
----
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L
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I
G
L
A
-----
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G
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----
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-
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P
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L
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----
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A
P
T
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Y
R
G
S
L
G
S
---------------
L
-
N
Q
L
M
I
T
I
-
G
I
--
L
-
A
A
Y
L
V
N
Y
--
A
F
A
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D
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E
G
W
R
W
M
-------------
L
G
L
--
A
---
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V
P
S
----
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I
L
L
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G
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F
M
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--------
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----
W
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----------
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-----
E
N
RNE-
E
--------------------------------
A
A
R
Q
V
M
K
I
T
YDDSE
I
D
K
E
--------
L
K
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T
-----
W
T
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I
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W
L
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C
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F
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---
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-
L
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A
---
A
----------
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
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G
N
I
---
G
M
I
A
S
L
L
I
M
--
A
I
L
I
W
T
IGI
A
------
S
---------
S
---
A
W
-----
I
----
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I
V
C
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S
-
L
F
I
-
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
-----------------
P
-
M
R---------------------
A
R
G
A
-
A
T
G
I
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S
A
L
V
L
N
I
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T
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L
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S
L
F
F
P
I
L
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D
A
L
S
-
T
E
W
V
F
L
I
F
A
F
I
G
V
L
------------------------------------------------------------------------------
22
Fugue
62.92
13%
-186
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
----------FKPAPHKAR
L
P
A
A
E
I
D
P
T
Y
R
R
L
---
R
W
Q
I
F
L
G
I
-----
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
-
P
Y
L
V
E
----
Q
G
--------------
F
S
R
G
D
L
G
F
A
L
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G
I
S
I
A
Y
G
F
S
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F
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G
S
V
S
D
R
S
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P
R
V
F
L
P
A
G
---
L
I
L
A
A
---
A
--
V
M
L
F
M
G
F
---
V
----
P
---
W
A
-------
T
S
S
I
A
V
----
M
F
V
L
L
F
L
C
-----
G
W
F
-----
Q
-
G
M
G
W
-
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
---------------
V
-
W
N
-
C
A
H
N
-
V
G
GG
I
-
P
P
L
L
F
L
L
--
G
M
A
------------------------
W
--------------------------
F
--------------
N
D
W
H
A
A
-------------
L
Y
M
--
P
---
A
F
C
A
----
I
L
V
A
L
F
A
F
--------
A
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M
R
D
T
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--------
Q
----
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GLPPIEEYKN
D
-----
T
-----
A
--------------------------------
K
-------------------------
Q
----------
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F
M
-----
Q
Y
V
L
P
N
----
K
L
L
W
Y
I
A
I
A
N
V
F
V
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L
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L
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L
D
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S
P
T
Y
L
K
E
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K
---
H
-
F
A
L
D
---
K
----------
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S
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A
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---
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-------
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N
---
P
T
-----
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----
D
M
I
C
M
I
-
V
I
G
-
F
L
I
Y
G
P
V
-
M
L
I
G
L
H
A
L
E
L
A
P----------------
K
-
K
----------------------
A
A
G
T
-
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
-
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
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W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
---
E
L
V
P
--------------------------------------------------
23
Fugue
62.03
15%
-177
- C3 -
1PV6
-
LACY_ECOLI
A:
[1-417]
------------------------
M
Y
Y
L
K
N
T
N
---
F
W
M
F
G
L
F
F
-----
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
-
H
D
--
I
----
N
H
--------------
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
---
I
T
G
M
L
V
M
F
A
--
P
F
F
I
F
I
F
---
G
----
P
---
L
L
-------
Q
Y
N
I
L
V
----
G
S
I
V
G
G
I
Y
LGFCF
N
A
G
-----
A
-
P
A
V
E
-
A
F
I
E
K
----
V
S
R
R
S
N
F
E
F
G
R
A
---------------
R
-
M
F
-
G
C
V
G
-
W
A
--
L
-
G
A
S
I
V
G
I
--
M
F
T
------------------------
I
--------------------------
N
--------------
N
Q
F
V
F
W
-------------
L
G
S
--
G
---
C
A
L
I
----
L
A
V
L
L
F
F
A
KTDAPSSA
T
V
A
N
A
V
G
--------
A
----
N
H
----------
S
-----
A
-----
F
--------------------------------
S
-------------------------
L
----------
K
L
A
-----
L
E
L
F
R
Q
----
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
-----
T
-----
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
-
Q
G
T
R
---
V
----------
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
---
I
M
S
V
R
I
I
G
S
--
S
F
-------
A
------
T
---------
S
---
A
L
-----
E
----
V
V
I
L
K
T
-
L
H
M
-
F
E
V
P
F
L
L
-
V
G
C
F
K
Y
I
T
S
Q
F
EV---------------
R
-
F
----------------------
S
A
T
I
-
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
---
N
E
V
A
--------------------------------------------------
4
PsiBlast_PDB
61.74
24%
-153
- C3 -
4JR9
1
NARK_ECOLI
A:
[50-437]
--------------------------------------------------
L
A
F
C
V
W
M
L
F
S
A
V
A
V
N
L
-
P
K
V-
G
----
F
N
--------------
F
T
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
F
G
G
R
R
W
T
A
F
S
---
T
G
I
L
I
---
I
--
P
C
V
W
L
G
F
---
A
----
V
---
Q
D
-------
T
S
T
P
Y
S
V
F
I
I
I
S
L
L
C
G
F
A
-----
G
A
N
-----
F
-
A
S
S
M
-
A
N
I
S
F
----
F
F
P
K
Q
K
Q
G
G
A
L
G
L
N
G
G
L
G
N
M
G
V
S
V
M
Q
L
V
-
A
P
-
L
V
V
S
-
L
-------------------------------------------------------------------------------------------------------
A
N
--
A
S
W
I
W
V
P
F
----
L
A
I
F
T
I
A
A
--------
W
F
G
M
N
D
L
--------
A
----------------------------------------------------------------------------------------------------------------------
L
W
I
M
S
L
L
Y
L
A
T
F
G
-----
S
-----
F
I
G
F
S
A
G
F
A
M
--
L
S
K
-
T
---
Q
-
F
P
D
V
---
Q
----------
I
L
Q
Y
A
F
F
G
P
F
I
G
A
L
A
R
S
A
G
G
A
L
S
D
R
L
G
G
T
R
V
T
L
V
N
F
I
---
L
M
A
I
-
F
S
G
L
LF
L
T
-------
L
------
P
---------
T
---
D
G
Q
G
G
S
F
M
----
A
F
F
A
V
F
-
L
A
L
F
L
T
A
G
L
G
S
-
G
S
T
F
Q
M
I
S
V
I
F
-----------------
R
-
K
L
T
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
A
T
D
T
A
A
-
A
L
G
F
-
I
S
A
I
G
A
I
G
G
-
F
F
I
P
K
A
F
G
S
S
L
A
L
T
G
S
--------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.52
24%
-160
- C3 -
4JRE
2
NARK_ECOLI
A:
[50-437]
--------------------------------------------------
L
A
F
C
V
W
M
L
F
S
A
V
A
V
N
L
-
P
K
V-
G
----
F
N
--------------
F
T
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
F
G
G
R
R
W
T
A
F
S
---
T
G
I
L
I
---
I
--
P
C
V
W
L
G
F
---
A
----
V
---
Q
D
-------
T
S
T
P
Y
S
V
F
I
I
I
S
L
L
C
G
F
A
-----
G
A
N
-----
F
-
A
S
S
M
-
A
N
I
S
F
----
F
F
P
K
Q
K
Q
G
G
A
L
G
L
N
G
G
L
G
N
M
G
V
S
V
M
Q
L
V
-
A
P
-
L
V
V
S
------------------------------------------------------------------------------------------
Y
-------------
L
A
N
--
A
S
W
I
W
V
P
F
----
L
A
I
F
T
I
A
A
--------
W
F
G
M
N
D
L
--------
A
----------------------------------------------------------------------------------------------------------------------
L
W
I
M
S
L
L
Y
L
A
T
F
G
-----
S
-----
F
I
G
F
S
A
G
F
A
M
--
L
S
K
-
T
---
Q
-
F
P
D
V
---
Q
----------
I
L
Q
Y
A
F
F
G
P
F
I
G
A
L
A
R
S
A
G
G
A
L
S
D
R
L
G
G
T
R
V
T
L
V
N
F
I
---
L
M
A
I
-
F
S
G
L
L
F
L
T
-------
L
------
P
---------
T
---
D
G
QGGS
F
M
----
A
F
F
A
V
F
-
L
A
L
F
L
T
A
G
L
G
S
-
G
S
T
F
Q
M
I
S
V
I
F
-----------------
R
-
K
L
T
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
A
T
D
T
A
A
-
A
L
G
F
-
I
S
A
I
G
A
I
G
G
-
F
F
I
P
K
A
F
G
S
S
L
A
L
T
G
S
--------------------------------------------------------------------------------------------
31
HHSearch
60.80
15%
-185
- C3 -
1PW4
-
GLPT_ECOLI
A:
[26-449]
----------------------------
L
R
W
Q
---
I
F
L
G
I
F
F
G
-----
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
---
E
----
Q
G
--------------
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
---
A
--
V
M
L
F
M
G
F
---
V
----
P
W
A
T
S
S
-------
I
A
V
M
F
V
----
L
L
F
L
C
G
W
F
-----
Q
G
M
G----
W
-
P
P
C
G
-
R
T
M
V
H
----
W
W
S
Q
K
E
R
G
G
I
V
S
---------------
V
-
W
N
C
A
H
N
V
-
G
G
--
G
-
I
P
P
L
L
F
L
--
L
G
M
------------------------
A
--------------------------
W
F-------------
N
D
W
H
A
A
-------------
L
Y
M
--
P
---
A
F
C
A
----
I
L
V
A
L
F
A
F
--------
A
M
M
R
D
T
P
--------
Q
----
S
C
GLPPIE----
E
Y----
K
-----
N
D---------------------------------------------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
----
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
-----
L
-----
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
-
F
A
L
D
---
K
----------
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
--
W
M
-------
N
PA----
G
---------
N
---
P
T
-----
V
----
D
M
I
C
M
I
-
V
I
G
-
F
L
I
Y
G
P
V
-
M
L
I
G
L
H
A
L
E
L
A
-----------------
P
-
K
K---------------------
A
A
G
T
-
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
-
G
E
K
R
R
H
E
Q
L
L
---
Q
E
L
---------------------------------------------------
48
HHSearch
60.78
17%
-174
- C3 -
4YB9
-
GTR5_BOVIN
D:
[69-453]
-----------------------------------------------------------------------------------------------
L
L
W
S
V
T
V
S
M
F
P
F
G
G
F
L
G
S
L
M
V
G
P
L
V
N
N
L
G
R
K
G
T
L
L
F
N
---
N
I
F
S
I
---
V
--
P
A
L
L
M
G
F
---
S
EL--
A
---
K
S
-------
F
E
M
I
I
V
----
A
R
V
L
V
G
I
C
-----
A
G
L
S----
S
-
N
V
V
P
-
M
Y
L
G
E
----
L
A
P
K
N
W
R
G
A
L
G
V
---------------
V
-
P
Q
L
F
I
T
I
-
G
I
--
L
-
V
A
Q
I
F
G
L
RS
L
L
A
------------------------
N
--------------------------
E
--------------
E
G
W
P
I
L
-------------
L
G
L
--
T
---
G
I
P
A
----
V
L
Q
L
L
F
L
---------
P
F
F
P
E
S
P
--------
R
----
Y
L
----------
L
IQKKD
E
-----
A
--------------------------------
A
AKSALRRLAEIEEILEEDRAEKAVG
F
----------
I
S
V
-----
L
K
L
F
K
M
----
R
S
L
R
W
Q
V
I
S
I
I
V
L
M
A
-----
G
QQLSG
V
N
A
I
Y
Y
Y
A
D
Q
I
Y
-
L
S
-
A
---
G
-
V
N
E
D
---
D
----------
V
Q
Y
V
T
A
G
T
G
A
V
N
V
L
I
T
V
C
A
I
F
V
V
E
L
M
G
R
R
F
L
L
L
L
G
F
S
---
V
C
F
T
A
C
C
V
L
--
T
G
AL-----
A
L-----
Q
DV-------
I
SWM
P
Y
-----
V
----
S
I
A
C
V
I
-
S
Y
V
-
I
G
H
A
L
G
P
S
P
I
P
A
L
L
V
T
E
I
F
-----------------
L
-
Q
S---------------------
S
R
P
A
-
A
Y
M
V
-
A
G
T
V
H
W
L
S
N
-
F
T
V
G
L
V
F
P
F
I
Q
V
G
L
G
-
A
-
Y
S
F
V
I
F
A
V
I
C
L
L
T
T
----------------------------------------------------------------------------
51
HHSearch
59.10
18%
-182
- C3 -
2CFQ
5
LACY_ECOLI
A:
[25-395]
---------------------------------------------------------
A
Y
F
P
F
F
P
I
W
-
L
H
--
D
I---
N
H
--------------
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
---
A
--
P
F
F
I
F
I
F
---
G
--------
P
L
L
------
Q
Y
N
I
L
V
----
G
S
I
V
G
G
I
Y
-----
L
G
F
CFNAG
A
-
P
A
V
E
-
A
F
I
E
K
----
V
S
R
--
R
S
N
F
E
F
G
---------------
R
-
A
R
M
F
G
C
V
-
G
W
--
A
-
L
G
A
S
I
V
G
--
I
M
F
------------------------
T
-----------------------------------------
I
N
N
Q
F
V
-------------
F
W
L
--
G
---
S
G
C
A
----
L
I
L
A
V
L
L
F
--------
F
A
K
T
D
A
P
--------
S
----
S
A
----------
T
V----
A
NAVGA
N
H
S
A
F
----------------------------
S
-------------------------
L
----------
K
L
A
-----
L
E
L
F
R
Q
----
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
-----
T
-----
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
-
Q
G
T
R
---
V
----------
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
---
I
M
S
V
R
I
I
G
S
--
S
F
-------
A
------
T
---------
S
---
A
L
-----
E
----
V
V
I
L
K
T
-
L
H
M
-
F
E
V
P
F
L
L
-
V
G
C
F
K
Y
I
T
S
Q
F
-----------------
E
-
V
R---------------------
F
S
A
T
-
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
--------------------------------------------------------------------------
42
HHSearch
56.30
12%
-168
- C3 -
4ZP0
3
MDFA_ECOLI
A:
[21-368]
---------------------------------------------------
T
Y
I
G
N
D
M
I
Q
P
G
M
L
A
V
-
V
E
--
Q
----
Y
Q
--------------
A
G
I
D
W
V
P
T
S
M
T
A
Y
L
A
G
G
M
F
L
Q
W
L
L
G
P
L
S
D
R
I
G
R
R
P
V
M
L
A
G
---
V
V
W
F
I
---
V
--
T
C
L
A
I
L
L
---
A
--------
Q
N
-------
I
E
Q
F
T
L
----
L
R
F
L
Q
G
I
S
-----
L
C
F
-----
I
G
A
V
G
Y
-
A
A
I
R
E
----
S
F
E
E
A
V
C
I
K
I
T
A
---------------
L
-
M
A
N
V
A
L
I
-
A
P
--
L
-
L
G
P
L
V
G
A
--
A
W
I
------------------------
H
--------------------------
V
--------------
L
P
W
E
G
M
-------------
F
V
L
--
F
---
A
A
L
A
----
A
I
S
F
F
G
L
Q
--------
R
A
M
P
E
T
A
--------
T
----
R
I
----------
G
-----
E
K
----
L
S
L
K
E
----------------------------
L
-------------------------
G
----------
R
D
Y
-----
K
L
V
L
K
N
----
G
R
F
V
A
G
A
L
A
L
G
F
V
S
L
-----
P
-----
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
-
E
---
Q
-
L
S
S
Y
---
E
----------
Y
G
L
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
L
L
A
R
L
T
S
R
R
T
V
R
S
L
I
I
M
G
G
W
---
P
I
M
I
G
L
L
V
A
--
A
A
A
T
V
I
S--
S
------
H
---------
A
---
Y
L
-----
W
----
M
T
A
G
L
S
-
I
Y
A
-
F
G
I
G
L
A
N
-
A
G
L
V
R
-
L
T
L
F
A
-----------------
S
D
M
----------------------
S
K
G
T
-
V
S
A
A
-
M
G
M
L
Q
M
L
I
F
-
T
V
G
I
E
I
S
K
H
A
W
L
N
G
G
---------------------------------------------------------------------------------------------
34
HHSearch
55.89
14%
-165
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[37-420]
--------------------------------------------------
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
--
A
----
F
T
--------------
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
---
L
--
G
A
A
L
F
W
P
---
A
----
A
E
I
-
M
N
-------
Y
T
L
F
L
V
----
G
L
F
I
I
A
A
G
-----
L
G
C
L
----
E
-
T
A
A
N
-
P
F
V
T
V
----
L
G
P
E
S
S
G
H
F
R
L
N
---------------
L
-
A
Q
T
F
N
S
F
-
G
A
--
I
-
I
A
V
V
F
G
Q
--
S
L
I
------------------------
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
--------------
L
S
V
Q
T
P
-------------
Y
M
I
--
I
---
V
A
I
V
----
L
L
V
A
L
L
I
M
L
-------
T
K
F
P
A
L
Q
--------
S
----
D
N
----------
H
-----
S
-----
D
A-------------------------------
K
QGS
F
---------------------
S
----------
A
S
L
-----
S
R
L
A
R
I
----
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
-----
A
-----
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
-
M
T
A
G
---
F
----------
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
---
I
A
M
A
L
C
L
I
S
--
A
F
-------
A
------
G
---------
G
---
H
V
-----
G
-----
L
I
A
L
T
-
L
C
S
-
A
F
M
S
I
Q
Y
-
P
T
I
F
S
L
G
I
K
N
L
-----------------
G
-
Q
----------------------
D
T
K
Y
-
G
S
S
F
-
I
-
V
M
T
I
I
G
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
----------------------------------------------------------------------------------
36
HHSearch
54.75
14%
-156
- C3 -
4ZW9
4
GTR3_HUMAN
A:
[47-453]
----------------------------------------------------
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
-
K
E
--
F
----
I
T
K
T
L
T
D
K
GNAPPS
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
V
---
T
--
G
G
C
F
M
G
L
CKV
A
--------
K
S
-------
V
E
M
L
I
L
----
G
R
L
V
I
G
L
F
-----
C
G
L
C
----
T
-
G
F
V
P
-
M
Y
I
G
E
----
I
S
P
T
A
L
R
G
A
F
G
T
---------------
L
-
N
Q
L
G
I
V
V
-
G
I
--
L
-
V
A
Q
I
F
G
L
--
E
F
I
------------------------
L
GS------------------------
E
--------------
E
L
W
P
L
L
-------------
L
G
F
--
T
---
I
L
P
A
----
I
L
Q
S
A
A
-
L
--------
P
F
C
P
E
S
P
--------
R
----
F
L
----------
L
INR--
K
E
E
---
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
-------------------------
Q
----------
V
T
V
-----
L
E
L
F
R
V
----
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
-----
S
Q
Q
L
SG
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--------
A
G
V
Q
---
E
----------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
---
G
M
A
F
C
S
T
L
M
--
T
V
-------
S
------
L
L
L
KDNY
N
G
M
S
---
F
V
-----
C
----
I
G
A
I
L
V
-
F
V
A
-
F
F
E
I
G
P
G
-
P
I
P
W
F
I
V
A
E
L
F
-----------------
S
-
Q
G---------------------
P
R
P
A
-
A
M
A
V
-
A
G
C
S
N
W
T
S
N
-
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
-
A
Y
V
-----------------------------------------------------------------------------------------
30
Fugue
53.65
19%
-132
- C2 -
3THI
1
THI1_PANTH
A:
[1-362]
I
T
L
K
V
A
I
YPYVPD
P
A
R
F
Q
A
A
V
L
D
Q
W
Q
R
Q
E
P
G
V
---
K
L
E
F
T
D
W
D
SYSAD
P
P
D
D
L
D
V
F
V
L
D
S
I
F
L
S
H
F
-
V
D
--
A
----
G
Y
--------------
L
L
P
F
G
S
Q
D
I
------
D
Q
A
E
D
V
L
P
F
A
L
Q
G
A
K
R
N
G
E
V
Y
G
L
P
Q
---
I
L
C
T
-------
N
L
L
F
Y
R
K
---
G
----
D
---
L
K
-------
I
G
Q
V
D
N
----
I
Y
E
L
Y
K
K
I
-----
G
T
S
-----
H
-
S
E
Q
I
-
P
----------
P
P
Q
N
K
G
L
L
I
N
---------------
M
-
A
G
------
G
T
--
T
-
K
A
S
M
Y
L
E
--
A
L
I
------------------------
D
--------------------------
V
--------------
T
G
Q
Y
T
E
-------------
Y
D
L
L
P
P
---
L
D
P
L
N
D
K
V
I
R
G
L
R
L
L
I
--------
N
M
A
G
E
K
P
--------
S
----
Q
Y
----------
V
-----
P
-----
E
--------------------------------
D
-------------------------
G
----------
D
A
Y
-----
V
R
A
S
W
F
----
A
Q
G
---------
S
G
R
-----
A
-----
F
I
G
Y
S
E
-----------------
S
M
M
---
R
----------
M
G
D
Y
A
E
-----
Q
V
R
F
K
P
----
I
S
S
S
A
G
Q
D
I
P
---
L
F
Y
---
S
D
V
V
S
V
N
S
K
--
T
A
-------
H
------
P
---------
E
---
L
A
-----
K
----
K
L
A
N
V
M
-
A
S
-------------
A
D
T
V
E
Q
A
L
-----------------
R
-
P
----------------------
Q
-----------
A
D
G
Q
Y
P
Q
-
Y
L
L
P
A
R
H
Q
V
Y
E
A
L
M
Q
D
Y
P
I
-
Y
S
E
L
A
Q
I
V
N
K
P
S
N
R
V
F
R
L
G
P
E
V
R
T
W
L
K
D
A
K
Q
---
V
L
P
E
ALG-----------------------------------------------