@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03340: (2016-06-05 )
MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDYFFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVYHQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMSVTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVKADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAFEIECRNEESIHLHDAYAKLCFSKEVDKI
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20......------..30....-----.....40......---..50....-....60..-----------------...--.--.--.70........80.....----------...90---------------......-------..100------.........110.......120.......130---...--------...-----------..140..-.....150..-----.--....160--------------......---...170.......180-.........190-...--------.....200.......210....-----...---220.......230-----------.....--....240-------....--...-..250.....---..260....----...270...--....280...-....290-.......300..----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNQHTLLP
K
K
T
E
R
L
Q
YFGSVSPIKGEK------PV
E
-
K
E
K
M
-----
K
D
L
Q
N
I
R
K
D
Y
F
F
D
---
I
Q
HVGVAN-VSH
P
V
T
I
T
-----------------
S
AM--M--P--AEQTTAA
N
F
T
M
TCNLPRN----------QKGI
N
---------------
M
S
R
L
T
E
-------
L
L
Q
--------
V
Y
HQN
G
W
I
L
S
F
S
S
L
Q
Q
F
T
K
E
L
A
ENMDTSS
A
T
----
V
E
V
--------
R
F
P
-----------
W
F
FERKS-PK
L
E
KAG
L
M
H
-----
A
--
D
I
F
M
S
----------------
V
T
YRKD---Q
P
F
K
Q
RAGIS
A
K
V
T
---
T
LCP
C
S
K
E
I
S
E
--
Y
SA--------HNQR
G
T
V
S
I
W
ADIHPAASLP
S
D
-----
V
K
A
---
D
L
L
H
AAESNAS-------------ARL
H
P
--
V
LKRP---------D
E
K
A
--
V
T
E
-TAYEN
P
R
F
V
E
---
D
L
A
R
L
I
A
A
D
----
L
F
E
L
E
W
V
S
A
--
F
E
I
E
CRNE
E
S
-
I
H
L
H
D
A
Y
-
A
K
L
C
F
SKEVDKI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.78
33%
-100
- C5 -
2R5R
2
GCH4_NITEU
A:
[23-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
A
---
I
D
R
V
G
I
K
A
-
I
R
H
P
V
V
V
A
-----------------
D
K
G
-----
G
--
G
S
Q
H
T
V
A
Q
F
N
M
Y
V
N
L
P
H
N
----------
F
K
G
T
H
---------------
M
S
R
F
V
E
-------
I
L
N
--------
S
H
E
R
E
---
I
S
V
E
S
F
E
E
I
L
R
S
M
V
S
R
L
E
S
D
S
G
H
----
I
E
M
--------
A
F
P
-----------
Y
F
I
N
K
S
A
-
P
V
S
G
V
K
S
L
L
D
-----
Y
--
E
V
T
F
I
----------------
G
E
I
K
H
G
---
N
Q
Y
S
F
T
M
K
V
I
V
P
V
T
---
S
L
C
P
C
S
K
K
I
S
D
--
Y
G
A
--------
H
N
Q
R
S
H
V
T
I
S
V
R
T
N
S
F
I
W
I
E
-------------
D
I
I
R
I
A
E
E
Q
A
S
-------------
C
E
L
Y
G
--
L
L
K
R
P
---------
D
E
K
Y
--
V
T
E
-
R
A
Y
N
N
P
K
F
V
E
---
D
I
V
R
D
V
A
E
V
----
L
N
H
D
D
R
I
D
A
--
Y
I
V
E
S
E
N
F
E
S
-
I
H
N
H
S
A
Y
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
75.65
34%
-94
- C5 -
2R5R
2
GCH4_NITEU
A:
[23-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
A
---
I
D
R
V
G
I
K
A
-
I
R
H
P
V
V
V
A
-----------------
D
K
G
--
G
--
G
---
S
Q
H
T
V
A
Q
F
N
M
Y
V
N
L
P
H
N
----------
F
K
G
T
H
---------------
M
S
R
F
V
E
-------
I
L
N
--------
S
H
E
R
---
E
I
S
V
E
S
F
E
E
I
L
R
S
M
V
S
R
L
E
S
D
S
G
H
----
I
E
M
--------
A
F
P
-----------
Y
F
I
N
K
S
A
-
P
V
S
G
V
K
S
L
L
D
-----
Y
--
E
V
T
F
I
----------------
G
E
I
K
H
G
---
N
Q
Y
S
F
T
M
K
V
I
V
P
V
T
---
S
L
C
P
C
S
K
K
I
S
D
--
Y
G
A
--------
H
N
Q
R
S
H
V
T
I
S
V
R
T
N
-----
S
F
I
-----
W
I
E
---
D
I
I
R
I
A
E
E
Q
A
S
-------------
C
E
L
Y
G
--
L
L
K
R
P
---------
D
E
K
Y
--
V
T
E
-
R
A
Y
N
N
P
K
F
V
E
---
D
I
V
R
D
V
A
E
V
----
L
N
H
D
D
R
I
D
A
--
Y
I
V
E
S
E
N
F
E
S
-
I
H
N
H
S
A
Y
-
A
L
I
E
R
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.47
37%
-84
- C5 -
3D2O
1
GCH4_NEIG1
A:
[14-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
L
P
---
I
N
Q
V
G
I
K
D
-
L
R
F
P
I
T
L
K
-----------------
T
A
------
E
--
G
T
Q
S
T
V
A
R
L
T
M
T
V
Y
L
P
A
E
----------
Q
K
G
T
H
---------------
M
S
R
F
V
A
-------
L
M
E
-----------
Q
H
T
E
V
L
D
F
A
Q
L
H
R
L
T
A
E
M
V
A
L
L
D
S
R
A
G
K
----
I
S
V
--------
S
F
P
-----------
F
F
R
K
K
T
A
-
P
V
S
G
I
R
S
L
L
D
-----
Y
--
D
V
S
L
T
-----------------
G
E
M
K
D
---
G
A
Y
G
H
S
M
K
V
M
I
P
V
T
---
S
L
C
P
C
S
K
E
I
S
Q
--
Y
G
A
--------
H
N
Q
R
S
H
V
T
V
--------
S
L
T
S
D
-----
A
E
V
G
I
E
E
V
I
D
Y
V
E
T
Q
A
S
-------------
C
Q
L
Y
G
--
L
L
K
R
P
---------
D
E
K
Y
--
V
T
E
-
K
A
Y
E
N
P
K
F
V
E
---
D
M
V
R
D
V
A
T
S
----
L
I
A
D
K
R
I
K
S
--
F
V
V
E
S
E
N
F
E
S
-
I
H
N
H
S
A
Y
-
A
Y
I
A
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
75.40
36%
-89
- C5 -
3D2O
1
GCH4_NEIG1
A:
[14-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
L
P
---
I
N
Q
V
G
I
K
D
-
L
R
F
P
I
T
L
K
-----------------
T
A
E
--
G
------
T
Q
S
T
V
A
R
L
T
M
T
V
Y
L
P
A
E
----------
Q
K
G
T
H
---------------
M
S
R
F
V
A
-------
L
M
E
--------
Q
H
T
E
---
V
L
D
F
A
Q
L
H
R
L
T
A
E
M
V
A
L
L
D
S
R
A
G
K
----
I
S
V
--------
S
F
P
-----------
F
F
R
K
K
T
A
-
P
V
S
G
I
R
S
L
L
D
-----
Y
--
D
V
S
L
T
----------------
G
E
M
K
D
----
G
A
Y
G
H
S
M
K
V
M
I
P
V
T
---
S
L
C
P
C
S
K
E
I
S
Q
--
Y
G
A
--------
H
N
Q
R
S
H
V
T
V
S
L
T
S
D
-----
A
E
V
-----
G
I
E
---
E
V
I
D
Y
V
E
T
Q
A
S
-------------
C
Q
L
Y
G
--
L
L
K
R
P
---------
D
E
K
Y
--
V
T
E
-
K
A
Y
E
N
P
K
F
V
E
---
D
M
V
R
D
V
A
T
S
----
L
I
A
D
K
R
I
K
S
--
F
V
V
E
S
E
N
F
E
S
-
I
H
N
H
S
A
Y
-
A
Y
I
A
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_CBE
75.01
37%
-86
- C5 -
3D2O
4
GCH4_NEIG1
B:
[15-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
---
I
N
Q
V
G
I
K
D
-
L
R
F
P
I
T
L
K
-----------------
T
A
------
E
--
G
T
Q
S
T
V
A
R
L
T
M
T
V
Y
L
P
A
E
----------
Q
K
G
T
H
---------------
M
S
R
F
V
A
-------
L
M
E
-----------
Q
H
T
E
V
L
D
F
A
Q
L
H
R
L
T
A
E
M
V
A
L
L
D
S
R
A
G
K
----
I
S
V
--------
S
F
P
-----------
F
F
R
K
K
T
A
-
P
V
S
G
I
R
S
L
L
D
-----
Y
--
D
V
S
L
T
-----------------
G
E
M
K
D
---
G
A
Y
G
H
S
M
K
V
M
I
P
V
T
---
S
L
C
P
C
S
K
E
I
S
Q
--
Y
G
A
--------
H
N
Q
R
S
H
V
T
V
--------
S
L
T
S
D
-----
A
E
V
G
I
E
E
V
I
D
Y
V
E
T
Q
A
S
-------------
C
Q
L
Y
G
--
L
L
K
R
P
---------
D
E
K
Y
--
V
T
E
-
K
A
Y
E
N
P
K
F
V
E
---
D
M
V
R
D
V
A
T
S
----
L
I
A
D
K
R
I
K
S
--
F
V
V
E
S
E
N
F
E
S
-
I
H
N
H
S
A
Y
-
A
Y
I
A
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.98
36%
-82
- C5 -
3D1T
2
GCH4_NEIG1
A:
[14-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
L
P
---
I
N
Q
V
G
I
K
D
-
L
R
F
P
I
T
L
K
-----------------
T
A
------
E
--
G
T
Q
S
T
V
A
R
L
T
M
T
V
Y
L
P
A
E
----------
Q
K
G
T
H
---------------
M
S
R
F
V
A
-------
L
M
E
-----------
Q
H
T
E
V
L
D
F
A
Q
L
H
R
L
T
A
E
M
V
A
L
L
D
S
R
A
G
K
----
I
S
V
--------
S
F
P
-----------
F
F
R
K
K
T
A
-
P
V
S
G
I
R
S
L
L
D
-----
Y
--
D
V
S
L
T
-----------------
G
E
M
K
D
---
G
A
Y
G
H
S
M
K
V
M
I
P
V
T
---
S
L
C
P
C
S
K
E
I
S
Q
--
Y
G
A
--------
H
N
Q
R
S
H
V
T
V
--------
S
L
T
S
D
-----
A
E
V
G
I
E
E
V
I
D
Y
V
E
T
Q
A
S
-------------
C
Q
L
Y
G
--
L
L
K
R
P
---------
D
E
K
Y
--
V
T
E
-
K
A
Y
E
N
P
K
F
V
E
---
D
M
V
R
D
V
A
T
S
----
L
I
A
D
K
R
I
K
S
--
F
V
V
E
S
E
N
F
E
S
-
I
H
N
H
S
A
Y
-
A
Y
I
A
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
51.93
14%
-208
- C- -
3R2E
-
?
A:
[0-83]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
M
D
I
V
F
I
E
E
-
L
S
V
I
T
T
I
G
-----------------
V
Y
D
W
E
Q
--
T
--
I
Q
Q
K
L
V
F
D
I
E
M
G
W
D
N
R
K
A
A
G
SDDV----
N
D
C
L
S
---------------
Y
A
D
I
S
E
-------
A
V
I
--------
Q
H
V
G
S
---
Q
R
F
A
L
V
E
R
V
A
E
E
V
A
E
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
48.67
16%
-205
- C5 -
2O90
1
FOLB_ECOLI
A:
[2-83]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
F
I
E
Q
-
L
S
V
I
T
T
I
G
-----------------
V
Y
D
W
E
Q
--
T
--
I
E
Q
K
L
V
F
D
I
E
M
A
W
D
N
R
K
A
A
K
S
DDV----
A
D
C
L
S
---------------
Y
A
D
I
A
E
-------
T
V
V
--------
S
H
V
E
G
---
A
R
F
A
L
V
E
R
V
A
E
E
V
A
E
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
46.68
10%
-208
- C5 -
3V9O
7
?
A:
[19-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
D
---
C
R
R
L
Y
L
R
N
-
H
E
V
Y
M
N
I
G
-----------------
A
----------
G
E
Q
R
V
V
I
N
V
D
L
F
V
P
L
A
L
T
TPVEDKL---
R
E
V
V
D
---------------
Y
D
L
M
K
Q
-------
S
V
A
--------
Q
C
V
A
R
---
G
H
I
H
L
Q
E
T
L
C
D
A
I
A
A
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
46.52
12%
-198
- C5 -
3O1K
1
?
A:
[15-98]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
D
K
V
F
I
E
Q
-
L
E
V
I
T
T
I
G
-----------------
V
Y
D
--
W
--
E
Q
Q
I
K
Q
K
L
V
L
D
L
E
M
A
H
D
N
R
A
A
G
K
S
DDV----
A
D
A
L
D
---------------
Y
A
Q
V
S
Q
-------
A
V
L
--------
E
H
I
E
Q
---
G
R
F
L
L
V
E
R
V
A
E
E
V
A
E
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
44.97
14%
-211
- C5 -
4AEY
-
?
A:
[6-90]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
---
M
A
R
I
R
V
K
D
-
L
R
L
R
T
F
I
G
-----------------
I
K
E
E
E
I
--
L
--
N
K
Q
D
V
L
I
N
L
T
I
L
Y
P
A
--------------
H
A
L
N
---------------
Y
R
T
I
T
K
-------
A
I
I
--------
R
H
V
E
E
---
N
R
F
A
L
L
E
R
M
T
Q
E
I
L
D
L
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
44.72
16%
-202
- C5 -
1B9L
-
FOLX_ECOLI
A:
[6-87]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
I
R
I
K
N
-
L
R
L
R
T
F
I
G
-----------------
I
K
E
E
E
I
--
N
--
N
R
Q
D
I
V
I
N
V
T
I
H
Y
P
A
D
K
A
R
T
S
EDI----
N
D
A
L
N
---------------
Y
R
T
V
T
K
-------
N
I
I
--------
Q
H
V
E
N
---
N
R
F
S
L
L
E
K
L
T
Q
D
V
L
D
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
39.07
8%
-180
- C5 -
1DHN
-
FOLB_STAAU
A:
[3-84]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
I
F
L
K
G
-
M
R
F
Y
G
Y
H
G
-----------------
A
L
S
A
E
N
--
E
--
I
G
Q
I
F
K
V
D
V
T
L
K
V
D
L
S
E
A
G
R
TDNV----
I
D
T
V
H
---------------
Y
G
E
V
F
E
-------
E
V
K
--------
S
I
M
E
G
---
K
A
V
N
L
L
E
H
L
A
E
R
I
A
N
R
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
38.49
11%
-149
- C5 -
1NBU
2
FOLB_MYCTU
A:
[3-84]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
I
E
L
R
G
-
L
T
V
H
G
R
H
G
-----------------
V
Y
D
--
H
ER
V
--
A
G
Q
R
F
V
I
D
V
T
V
W
I
D
L
A
E
A
A
N
S
DDL----
A
D
T
Y
D
---------------
Y
V
R
L
A
S
-------
R
A
A
--------
E
I
V
A
G
---
P
P
R
K
L
I
E
T
V
G
A
E
I
A
D
H
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
37.72
17%
-73
- C1 -
4DDU
3
RGYR_THEMA
A:
[2-1103]
AVN
S
K
Y
H
HSCINCGGLNT
D
E
R
N
E
R
GLPCEVCLPEDSPSD
I
Y
R
A
L
L
E
R
KTLKE
Y
R
F
Y
H
E
F
W
N
E
Y
E
D
F
R
S
F
F
K
K
K
F
G
K
D
L
T
G
Y
Q
R
L
W
A
K
R
I
V
Q
G
K
S
F
T
MVAPTGVG
K
T
T
F
G
M
M
T
A
L
W
L
A
R
K
G
K
K
S
A
L
V
F
PT
V
T
L
V
K
Q
T
L
E
R
L
Q
K
L
ADEK
V
K
I
F
G
F
Y
SSMK
K
E
E
K
E
K
F
E
K
S
F
E
EDDYH
I
L
V
F
S
T
Q
F
V
S
K
N
R
E
K
L
S
Q
KRFD
F
V
F
V
DD
V
D
A
V
L
KA
S
R
N
I
D
T
L
L
M
M
VGIP
E
E
I
I
R
K
A
F
S
T
I
K
Q
G
K
I
Y
E
R
P
K
N
L
K
P
G
I
L
V
V
S
S
A
T
A
K
P
----------------------
R
G
I
R
P
L
L
F
R
D
---
L
L
N
F
T
V
G
R
L
V
S
V
A
R
N
I
T
-----------------
H
V
R
--
I
--
S
--
S
R
------------------------------
S
---------------
K
E
K
L
V
E
-------
L
L
E
--------
I
F
R
-
D
G
-
I
L
I
F
A
Q
T
E
E
E
G
K
E
L
Y
E
Y
L
K
R
F
K
F
N
----
V
G
E
--------
T
W
S
------------
E
F
E
K
N
F
-
E
D
F
K
V
G
K
I
----------
N
I
L
I
G
----------------
V
Q
-
A
Y
Y
---
G
K
L
T
R
G
V
D
L
P
E
R
I
K
--------------------------------
Y
V
I
F
W
G
T
P
S
M
R
F
S
L
E
L
D
KA---
P
R
F
---
V
L
A
R
V
L
K
E
M
G
L
-------------
I
K
A
Q
E
--
N
P
D
V
E
---------
E
L
R
K
--
I
A
K
-
E
H
L
T
Q
K
E
F
V
E
---
K
V
K
E
M
F
R
G
V
----
V
V
K
-------------
D
E
D
L
E
-
L
I
I
P
D
V
Y
-
T
Y
I
Q
A
S
G
R
S
S
R
I
LNGVL
V
K
G
V
S
V
I
F
E
ED
E
E
I
F
E
S
L
K
T
R
L
L
L
IAE
E
E
I
I
E
EAEAN
W
K
E
L
V
H
E
V
E
E
S
R
R
R
S
E
R
E
L
T
D
T
S
R
S
L
L
I
I
V
E
S
P
T
K
A
E
T
L
S
R
F
L
GRA
S
S
R
K
E
RN
I
I
V
H
E
A
V
T
GE
G
V
I
L
F
T
A
TRGHVYDLVTKGGIHG
V
E
E
E
NG
K
F
V
P
V
Y
N
S
L
K
R
C
RDCGYQFTEDRDECPVCSSKNIDD
K
T
E
T
L
R
A
L
R
E
I
S
L
E
AD
E
I
L
V
A
T
D
PD
V
E
G
E
K
I
S
W
D
V
T
Q
Y
L
L
PSTR
S
L
R
R
I
E
M
HEIT
R
Y
G
F
K
K
A
R
E
S
VRFVD
F
N
L
V
K
A
Q
I
V
R
R
V
Q
D
R
W
I
G
F
E
L
S
G
K
L
Q
K
R
FGRSNLSAG
R
V
Q
S
T
V
L
G
W
I
V
E
R
E
E
E
Y
K
K
S
E
K
D
F
T
L
L
V
L
E
N
G
V
N
L
E
V
E
G
KIADD
V
V
T
V
V
E
L
Q
E
A
E
E
E
K
N
P
L
P
P
YT
T
S
S
A
L
S
E
I
S
Q
K
L
RLG
V
Q
E
V
M
D
I
L
Q
D
L
F
E
K
GFITYHRTDSTRIS
L
E
G
Q
N
V
A
R
T
Y
L
R
K
I
GKEDI
F
M
G
R
SWSTEGAHEAIRPVKPID
A
R
E
L
E
E
M
I
E
E
GLIADLT
K
K
H
L
R
V
Y
E
L
I
F
N
R
F
L
A
S
Q
S
A
A
V
K
V
K
K
Q
I
V
T
V
D
V
DG
K
R
M
G
I
E
Q
I
V
E
ILRDGWNLF
V
P
L
T
V
S
P
R
F
E
H
R
T
Y
K
I
K
E
K
K
F
Y
K
K
H
T
V
P
L
F
T
Q
A
S
I
V
E
E
M
K
K
R
GIGRPST
Y
A
K
I
V
E
V
L
F
R
R
GY
V
Y
E
D
KYK
R
V
R
P
T
R
F
G
V
M
V
Y
S
Y
L
K
E
RYEKYVT
E
E
T
T
R
R
L
E
E
I
M
D
K
V
E
R
GEED
Y
Q
A
T
L
R
L
L
Y
E
E
I
K
S
L
M
E
E
27
Fugue
35.61
17%
-5
- C4 -
4IC4
-
OSH3_YEAST
A:
[625-996]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K
S
V
T
R
R
N
D
I
P
E
A
A
A
S
P
P
S
L
L
S
F
L
R
K
N
V
G
K
D
LSSIAM
P
V
T
S
N
E
P
I
-----
S
I
L
Q
L
I
S
E
T
F
E
Y
A
---
P
L
L
T
K
A
T
Q
-
R
P
D
P
I
T
F
V
-----------------
S
A
F
--
A
--
I
--
S
F
L
S
I
Y
R
D
K
T
R
T
L
R
K
P
F
N
PLLA
E
T
F
E
L
I
R
E
D
M
G
---------------
F
R
L
I
S
E
-------
K
V
S
HRP
P
V
F
A
F
F
A
E
H
L
D
W
E
C
S
Y
T
V
T
P
S
Q
K
F
W
G
K
S
I
E
L
N
N
E
G
I
----
L
R
L
--------
K
F
K
TTG--------
E
L
F
E
W
T
Q
-
P
T
T
I
L
K
N
L
I
A
-----
G
--
E
R
Y
M
E
P
V
N
E
F
E
V
H
S
SKG
D
K
S
H
I
L
F
D
K
A
---
G
M
F
S
G
R
S
E
-
G
F
K
V
S
---
I
I
P
P
P
S
S
N
R
K
K
--
E
T
L
A
G
K
WT
Q
S
L
A
N
E
T
T
H
E
T
I
W
E
-
V
G
D
L
V
S
N
P
K
K
KYGFT
K
F
T
---
A
N
L
N
E
I
T
E
I
E
K
-------------
G
N
L
P
P
TD
S
R
L
R
P
---------
D
I
R
A
--
Y
E
E
G
N
V
D
K
A
E
E
W
K
L
---
K
L
E
Q
L
Q
R
E
R
----
R
N
K
G
Q
D
V
E
P
KY
F
E
K
V
S
K
N
E
W
K
Y
I
T
G
P
K
S
Y
-
W
E
R
R
K
K
H
D
W
S
D
I
SQLW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
35.22
11%
-66
- C4 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
S
D
--
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
------
I
G
D
-
T
D
D
G
-----
T
G
L
H
H
M
V
F
E
V
V
D
N
---
A
I
D
E
A
L
A
G
-
H
C
K
E
I
I
V
T
IHADN
S
V
S
V
Q
D
DGRGIP
T
G
I
--
H
--
P
--
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
----------
K
F
D
D
N
SYKVSGGLHGV
G
V
S
V
V
N
A
L
S
Q
-------
K
L
E
--------
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
A
P
L
A
V
T
G
E
T
--E
K
T
G
T
M
V
--------
R
F
W
P
SLETFTNVTE
F
E
Y
E
I
L
A
-
K
R
L
R
E
L
S
F
L
D
-----
S
--
G
V
S
I
R
----------------
L
R
D
K
R
D
G
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
---
Y
L
N
K
N
K
T
P
I
H
P
NI
F
Y
F
--------
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
Q
E
N
-----
I
Y
C
----
F
T
N
N
I
P
Q
R
D
G
-------------
G
T
H
L
A
--
G
F
R
A
A
---------
M
T
R
T
--
L
N
A
-
Y
M
D
K
E
G
Y
S
K
K
---
A
K
V
S
A
T
G
D
D
A
R
EG
L
I
A
V
V
S
V
K
V
--
P
D
P
K
F
S
S
Q
T
K
-
D
K
L
V
S
S
E
-
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
MT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
33.95
17%
-39
* C4 *
5AYC
3
?
A:
[1-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIH
E
K
Y
T
E
M
R
N
E
Q
E
A
L
L
S
R
K
N
T
K
T
S
F
Y
N
G
I
Y
D
R
Y
E
H
P
------
V
L
T
-
R
E
H
I
PLHWR
Y
D
L
N
K
E
T
N
P
F
F
Q
E
RLG
I
N
A
V
F
N
A
G
-
A
I
K
L
N
D
R
Y
-----------------
C
L
V
--
A
--
R
--
V
E
G
N
D
R
K
S
F
F
A
V
A
E
S
D
K
G
----------
T
E
G
F
R
F
R
QYPVC--------
L
P
A
L
T
D
DETNVYD
M
R
L
--------
T
Q
H
E
D
G
W
I
Y
G
V
F
C
V
E
K
S
A
G
T
A
D
L
S
E
A
V
A
S
A
G
----
I
A
R
T
KDLT
N
W
E
R
L
P
-----------
D
L
V
T
L
R
S
-
P
Q
Q
R
N
V
T
L
L
P
EFVDG
K
--
Y
A
F
Y
T
----------------
R
P
M
D
G
F
---
I
E
T
G
S
G
G
G
I
G
F
G
L
A
DDI
T
H
A
V
I
D
E
E
--
R
--
M
T
S
--------
I
R
R
Y
H
T
I
T
--
E
S
K
N
G
A
G
A
T
P
I
K
-----
T
E
R
GWL
N
I
A
H
G
V
R
N
T
A
A
G
L
R
Y
V
I
Y
C
F
V
T
D
L
S
E
P
W
K
--
V
I
A
E
P
GGYLIAPF
K
D
E
R
V
GD
V
S
N
-
V
V
F
T
N
G
A
I
V
D
DNG
D
V
Y
I
Y
Y
A
S
S
----
D
T
R
L
H
V
A
V
S
--
S
I
D
K
L
L
D
Y
A
F
-
N
T
P
A
D
A
L
R
T
A
E
C
V
K
Q
R
C
D
L
I
K
R
N
I
E
L
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
29.08
14%
-66
- C2 -
4LL1
-
TXNIP_HUMAN
A:
[7-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
S
F
E
V
V
F
N
D
P
E
K
--
V
Y
G
S
G
E
K
V
A
G
R
V
------
I
V
E
------------
V
C
E
V
T
R
V
K
A
V
R
---
I
L
A
C
G
V
A
K
-
V
L
W
M
Q
G
S
Q
-----------------
Q
C
K
--
Q
--
T
--
S
E
Y
L
R
Y
E
D
T
L
L
L
E
D
Q
P
T
G
----------
E
N
--
E
---------------
M
V
I
M
R
P
-------
G
N
K
--------
Y
E
Y
K
F
G
F
E
L
P
-------
Q
G
P
L
G
T
S
F
K
G
K
Y
G
S
----
V
D
Y
--------
W
V
K
-----------
A
F
L
D
R
P
S
Q
P
T
Q
E
T
K
K
N
F
E
-----
V
VP
D
L
M
A
P
----------------
V
S
A
K
K
E
---
K
K
V
S
S
M
F
I
P
D
G
R
V
S
---
V
S
A
R
I
D
R
K
-------
G
--------
F
C
E
G
D
E
I
S
I
H
A
D
F
E
N
T
S
S
R
I
V
V
-----
P
K
A
---
A
I
V
A
R
H
T
Y
L
A
N
-------------
G
Q
T
K
V
--
L
T
Q
K
L
---------
S
S
V
R
--
G
N
H
I
I
S
G
T
C
A
S
W
R
G
---
K
S
L
R
V
Q
K
I
N
----
I
L
R
V
E
Y
S
L
L
--
I
Y
V
S
V
P
G
S
K
K
-
V
I
L
D
----
L
P
L
V
I
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
28.96
30%
-140
- C5 -
2JOV
-
?
A:
[19-76]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
V
P
V
K
S
N
K
------
P
V
E
-
I
S
K
W
-----
I
D
F
S
N
V
L
S
R
L
Y
--------
V
G
V
P
T
-
K
S
G
N
V
V
C
K
-----------------
N
I
M
-----------
N
T
G
V
D
I
I
C
T
K
N
L
P
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------