@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03480: (2016-06-06 )
MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDYVLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQWSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYLELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASAGGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTFMGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLINDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTGKLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARAGGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGVGPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTESKVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQVHHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGAALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFKEAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQPEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEYLGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSEFAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAPRNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLFEHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPAAAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGRSDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELARIYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPVQSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPSAGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVEDLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDEGIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQFNPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGAGEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQRKLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIVTHANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLDMARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQTVGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAGIAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGRIDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQEMREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTEQKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTVEGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLTGELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERIVSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGETLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFEGDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRSQADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQVQRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTFVLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKALPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVEHHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLDIVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIELSEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIPAFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGGLLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSFAEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTAEETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTISRTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDVAFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLTMSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDKLMEIF
Atome Classification :
(21 SA)
.........10........20........30....-....40....-.....50........60........70........80........90...--.....100.......110.......120.......130.......140.......150.......160.......---170.......180.......190.......200.......210......--.220.......230.......240.......250.......260.......270.......280--.......290.......300.......310.......320.......330.......-340.......350.......360..---------.....370----..---......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570..-.----....580...-....590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830..-.....840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120-......1130......1140------......----.---.1150.......1160......1170......1180......1190......1200...------...1210---........1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320..--....1330......1340......1350......1360......1370......1380......1390......1400....-----..1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520...-...1530......1540......1550......1560......1570......1580......1590......1600......1610......1620-......1630....--..1640.....-.1650......------------1660......1670--.....-.1680........1690......1700......1710......1720......1730......1740......1750.----.....1760......1770......1780....-..1790......1800.-....--.1810---......1820..-....1830....-..-1840......1850......1860......1870..-..-..1880......1890......1900......1910......1920......1930......1940......1950.....-----.1960......1970......1980......1990.-.....2000......2010......2020......2030....-..2040......2050.....-.2060......2070......2080......2090....-..2100......2110--......2120......2130----.....-..2140......2150......2160......2170.....-.2180---.--..----...-2190.......2200.......2210......2220......2230......2240...--..----.--2250.......2260......2270......---2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440..--------------..--------------..2450......2460......-2470-.-.....2480......2490......2500......2510......2520......2530......2540......2550....---..2560......2570......2580......2590......2600......2610......2620......2630......2640....-------..2650---.------....--....2660......2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780......2790......--------2800--.........2810.-----.....------2820.......2830......2840------......2850......2860......2870......2880......2890......2900...-...-2910......2920-.......2930......2940......2950......2960..------....2970....-...2980---.......2990......3000......3010......3020..--....3030......3040......3050......3060......3070......3080.-.-....3090......3100.....-.3110......3120......3130......3140......3150.--.....3160.....--.3170......3180......3190......3200......3210......3220......3230......3240......3250......3260......3270......3280......3290......3300......3310......3320......3330......3340......3350......3360......3370......3380......3390......3400......3410......3420......3430......3440......3450......3460......3470......3480......3490......3500......3510......3520......3530......3540......3550......3560......3570......3580....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
I
T
F
Y
PLTDAQ
K
R
I
W
Y
T
E
KFYPHTS
I
S
N
L
A
G
I
G
K
-
L
VSAD-
A
I
D
Y
-
V
L
V
E
Q
A
I
Q
E
F
I
RRND
A
M
R
L
R
L
R
LDENG
E
P
V
Q
Y
I
S
EYRPV
D
I
KHTDTTEDP--
N
A
I
E
F
I
S
Q
W
S
R
E
ETKKPLPLYDCD
L
F
R
F
S
L
F
T
I
KEN
E
V
W
F
Y
A
N
V
H
H
V
I
SDGI
S
M
N
I
L
G
N
A
I
M
H
I
Y
L
E
LASGSETK---EG
I
S
H
S
F
I
D
H
V
L
S
E
Q
E
Y
A
Q
S
KRF
E
K
D
K
A
F
W
N
K
Q
F
E
S
V
P
E
L
V
S
L
KRNASA--GGSL
D
A
E
R
F
S
K
D
V
P
E
A
L
H
Q
Q
I
L
S
F
C
EAN
K
V
S
V
L
S
V
F
Q
S
L
L
A
A
Y
L
Y
RVSGQN
D
V
V
T
G
T
FMGNRTN--
A
K
E
K
Q
M
L
G
M
F
V
STVPLRTNID
G
G
Q
A
F
S
E
F
V
K
D
R
M
K
D
L
M
K
T
L
R
HQKY
P
Y
N
L
L
I
N
D
L
R
E
-
T
K
S
S
L
T
K
L
F
T
V
S
L
E
Y
Q
V
M
QWQKEE
D
---------
L
A
F
L
TEP-----IF---SGSGL
N
D
V
S
I
H
V
K
DRWDTG
K
L
T
I
D
F
DYRTDLF
S
R
E
E
I
N
M
I
C
E
R
M
I
T
M
L
E
N
ALTHPEH
T
I
D
E
L
T
LIS
D
A
E
K
E
K
L
L
A
RAGGKSVSYRKDMT
I
P
E
L
F
Q
E
K
A
E
L
LSDHP
A
V
V
F
EDRTLS
Y
R
T
L
H
E
Q
S
A
R
I
A
N
V
L
K
QKGVGPDS
P
V
A
V
L
I
ERS
E
R
M
I
T
A
I
M
G
I
L
KAG
G
A
Y
V
PIDPGF
P
A
E
R
I
Q
Y
I
L
E
DCGA
D
F
I
L
TESKVAAPEAD-A----
E
L
I
D
L
D
Q
A
I
E
-EG
A
E
E
SLNADVNA
R
N
L
A
Y
I
I
YTSGTTGRPK
G
V
M
I
E
H
R
Q
V
H
H
L
V
E
S
L
Q
Q
T
I
Y
QSG
S
Q
T
L
R
M
A
L
LAPFHF
D
A
S
V
K
Q
I
F
A
S
L
LLG
Q
T
L
Y
I
V
PKKTVTNG
A
A
L
T
A
Y
Y
RKNSIEATDG
T
P
A
H
L
Q
M
L
A
AAGDFEG
L
K
L
K
H
M
L
IGG
E
G
L
S
S
V
V
A
D
K
L
L
K
L
F
K
EAGTAPR
L
T
NVYGPTETCVDASVHPVI
P
E
N
A
V
Q
S
A
Y
V
P
I
G
K
ALGNN
R
L
Y
I
LDQKGRLQPEGVA
G
E
L
Y
I
AGDGVGRGYLHLPEL
T
E
E
K
FLQDPFV-PGD
R
M
Y
RTGD
V
V
R
WLPDG
T
I
E
YLGRED
D
Q
V
K
V
R
G
Y
R
I
E
L
G
E
I
E
A
V
I
Q
QAP
D
V
A
K
A
V
V
L
ARPDEQG
N
L
E
V
C
A
Y
V
V
QKPGSEFA
P
A
G
L
R
E
H
A
A
R
QL
P
D
Y
M
V
P
A
Y
F
T
EVTEIPLTPSGKVD
R
R
K
L
F
A
L
E
V
K
A
VSG
T
A
YTAPRN
E
T
E
K
A
I
A
A
I
W
Q
D
V
L
N
V
E
K
AG
I
F
D
N
F
F
E
TGGH
S
L
K
A
M
T
L
L
T
K
I
H
K
ETGI
E
I
P
L
Q
F
L
FEHP
T
I
T
A
L
A
E
E
ADHRES
K
A
F
A
V
IEPAEKQEHYP
L
S
L
A
Q
Q
R
T
Y
I
V
S
QFEDAGVGYNM
P
A
A
A
I
LEGPL
D
I
Q
K
L
E
R
A
F
Q
G
L
I
R
R
H
E
S
LR
T
S
F
V
LEN-ST
P
R
Q
KIHDSVDF
N
I
E
M
I
--------ERGGRS----
D
---
E
A
-
I
M
A
S
F
V
R
T
F
D
L
A
KA
P
L
F
R
I
G
LLGLEEN
R
H
M
L
L
F
D
M
H
H
L
I
SDGV
S
I
G
I
M
L
E
E
L
A
R
I
Y------KGEQL-----P
D
L
R
L
Q
YK
D
Y
A
V
W
QS
R
Q
A
AEGYK
K
D
Q
A
Y
W
K
E
V
FAGE
L
P
V
L
Q
L
L
SDYPRPP
V
Q
SFEG
D
R
V
S
I
K
LDAG
V
K
D
R
L
N
R
L
A
E
QNG
A
T
L
Y
M
V
M
L
S
A
Y
Y
T
L
L
S
KYTGQD
D
I
I
V
GTPSAGRNH--SDT
E
G
I
I
G
M
F
V
N
T
L
A
I
R
S
E
VKQN
E
T
F
T
Q
L
I
S
R
V
R
K
R
V
L
D
A
FSHQDY
P
F
E
W
L
V
E
DLNIPRDVSRH
P
L
F
D
T
M
F
S
L
Q
NATEGIPA-----VG
D
L
S
L
S
V
QET
N
F
K
I
A
K
F
D
L
T
V
Q
ARETDE
G
I
E
I
D
VDYS
T
K
L
F
K
Q
S
T
A
D
R
L
L
T
H
F
A
R
L
L
E
D
AAADPEK
P
I
S
E
Y
KLL
S
E
E
E
A
A
S
Q
I
Q
QFNPGRTPYPK
D
K
T
I
V
Q
L
F
E
E
QAANTPDH
T
A
L
Q
Y-EGES
L
T
Y
R
E
L
N
E
R
A
N
R
L
A
R
G
I
L
SLGAGEG
R
T
A
A
V
L
C
E
R
S
M
D
M
I
V
S
I
L
A
V
LKSG
S
A
Y
VPIDPEH
P
I
Q
R
M
Q
H
F
F
R
DSG
A
K
V
L
L
T
Q
R
K
L
K
A
L
A
E
EAEFK
G
-
V
I
V
L
ADEEESYHAD--ARNLALPLDSA-
A
M
A
N
L
T
YTSGT------------TGTPKG
N
I
V
T
H
A
N
I
--
L
R
T
V
K-ET
N
--
Y
L
S
ITEQD
T
I
L
G
L
S
N
Y
V
F
D
A
F
M
F
D
M
F
G
S
L
LNG
A
K
L
V
L
I
P
K
E
T
V
L
D
M
A
R
L
S
R
V
I
E
REN
I
S
I
L
M
I
T
T
A
L
F
H
L
L
V
D----L
N
P
A
C
L
S
T
L
R
K
I
MFGGER
A
S
V
E
H
V
R
K
A
L
Q
TVGK-G
K
L
L
H
M
YGPSE
S
T
V
F
A
T
-YH
P
V
--
D
E
L
E
E
---HTLSVPIGKPVS-N
T
E
V
Y
I
L
DRTGH-VQ-PAGIA
G
E
L
C
VSGE
G
L
V
K
GYYNRPELTEEKFVPHPFT-SG-E
R
M
YKTG
D
L
A
R
WLPNGD
I
E
F
I
GRID
H
Q
V
K
I
RGQRI
E
L
G
E
I
E
H
Q
L
Q
T
H
D
R
V
Q
E
S
V
V
L
A
V
DQGAG
D
K
L
L
C
A
Y
Y
VGEGDI
S
S
Q
E
-----
M
R
E
H
A
A
KDL
P
A
Y
M
V
P
A
V
F
I
QMDELPLTGNGKIDRRA-LPIPD
A
N
V
SRG
V
S
Y
VAPRNG
T
E
Q
K
V
A
D
I
W
A
Q
V
L
Q
A
E
QVGAYD
H
-
F
F
DIGGH
S
L
A
G
M
K
M
L
A
L
V
H
Q
E
-LG
V
E
L
S
L
K
D
L
FQSP
T
V
E
G
L
A
Q
V
I
A
SAEKGTAASISPAEK-QDTYPVS
S
P
Q
K
R
M
Y
V
L
--
Q
Q
L
E
D
A
Q
TSYNM
P
A
V
L
R
LT-----GEL
D
V
-
E
R
L
N
S
V
M
Q
Q
L
M
Q
R
H
E
A
L
R
T
T
F
EIKD
G
E
T
V
Q
R
I
W
E
EAE
C
E
I
A
-
Y
F
EA
P
---
E
--
E
E
----
T
E
R
-
I
V
-
S
E
F
I
K
PFKID-QL
P
L
F
R
I
G
L
IKHSDT
E
H
V
L
L
F
D
M
H
H
I
ISDGAS
V
G
V
L
I
E
E
L
S
K
LYD--GE----T--L-
E
P
L
R
I
Q
Y
K
D
Y
A
V
W
Q
Q
Q
F
I
Q
S
E
L
Y
K
K
Q
E
E
H
---
W
L
K
E
LDGEL
P
V
L
TLPTDYSRPAVQTFEG
D
R
I
A
F
S
LEAG
K
A
D
A
L
R
R
L
A
K
ETDST
L
Y
M
V
L
L
A
S
Y
S
A
F
L
S
KISGQD
D
I
I
VGSPVAGR
S
Q
A
D
V
S
R
V
I
G
M
F
V
N
T
L
A
LRTYPKG
E
K
T
F
A
D
Y
L
N
E
V
K
E
T
A
L
S
AFDAQDY
P
L
E
D
L
IG
N
V
Q
V
Q
RDTSRN
P
L
F
D
A
V
F
S
MQNANIK
D
--------------
L
T
--------------MKGIQLEPHPFERKT
A
K
F
D
L
T
L
-
T
ADE-T-DG
G
L
T
F
V
L
EYN
T
A
L
F
K
Q
E
T
I
E
R
W
K
Q
Y
W
M
E
L
L
D
A
VTGNPNQPL
S
S
L
S
L
V
T
E
T
E
K
Q
A
L
L
E
AWKGKALPVPT
D
K
T
V
H
Q
L
F
E
E
T
A
Q
R
---HKDRP
A
V
T
YNGQS
W
T
YGEL
N
A
K
A
N
R
L
A
R
I
L
M
DCGISPDDRV
G
V
L
TKP
S
L
E
M
S
A
A
V
L
G
V
L
KAG
A
A
F
VPIDPDY
P
D
Q
R
I
E
Y
I
L
QDSG
A
K
L
L
L
-------KQE------G------ISVP--DSYTG
D
V
I
L
LDGS
R
T
I
L
S
LPLDENDEENPE
T
A
V
TAE
N
L
A
Y
M
I
Y
TSGTTGQPK
G
V
M
V
E
H
H
A
L
V
N
L
C
F
WHHDAFSMTAEDRSAKYAGFGF
D
A
S
I
W
E
MFPTWTIG
A
E
L
H
V
I
E
E
A
I
R
L
D
I
V
R
LN
D
Y
FETN
G
V
T
I
T
FL
P
T
Q
L
A
E
Q
F
M
E
L--------E-----NT
S
L
R
V
L
LTG
G
D
K
L
-----
K
R
A
V
K------K-PY
T
L
VNNYGPTE
N
T
V
V
A
TS
A
E
IH------PEEGS
L
S
I
G
R
A
IAN
T
R
V
Y
I
L
GEGNQVQPEGVAG
E
L
C
VAG
R
G
L
A
R
G
YLNRE
D
E
T
A
K
R
F
VADPFV-PGE-RMYRTG
D
L
V
K
W-TG-G
G
I
E
Y
I
G
RID
Q
Q
V
K
V
R
G
Y
R
I
E
L
S
E
I
E
V
Q
L
A
Q
L
S
E
V
Q
D
A
A
V
T
A
V
------KDKGG
N
-
T
A
I
A
A
-
Y
VTPE-S---A
D
I
E
A
L
K
S
A
L
K
E
TL
P
D
YMI
P
A
F
W
V
T
L
NELPVTANGKVDRKALP--EPDIEAGSGEYKAPTT
D
M
E
E
L
L
A
G
I
W
Q
D
V
LGMSEVGVTD
N
F
F
SLGGDSI
K
G
I
Q
M
A
S
R
L
N
-Q-HG
W
K
L
E
M
K
D
L
FQHP
T
I
E
E
L
T
Q
Y
V
-
E
R
AEGKQADQGPVEG
E
V
I
L
T
P
I
Q
R
W
F
F
EKNFTNKHHWNQ
S
V
M
L
H
AK--KGF
D
P
E
R
V
E
K
T
L
Q
A
--
L
I
E
H
H
D
A
L
R
M
V
Y
REG
Q
E
D
V
I
Q
Y
NRGLEAAS
A
Q
L
E
V
I
Q
IEGQAA
D
Y
E
D
R
I
E
R
E
A
E
R
L
Q
S
SIDLQEG
G
L
L
KAGLFQAEDGD
H
L
L
L
A
I
H
H
L
V
VDGV
S
W
R
I
L
L
E
D
F
A
A
V
Y
T
Q
L
EQGNEPVLPQKT
H
S
F
A
E
Y
A
E
R
L
Q
D
F
AN
S
K
A
F
L
K
E
K
E
Y
W
R
Q
L
E
E
Q
A
V
A
A
KLPKDRES
G
D
Q
R
M
K
H
T
K
T
I
E
F
S
L
T
A
E
E
T
E
Q
L
T
T
K
V
H
E
A
Y
H
T
E
M
N
D
I
L
L
T
A
F
G
L
A
M
K
EWTGQ
D
R
V
S
V
H
L
EGH
G
R
E
E
I
I
E
D
L
TIS
R
T
V
G
W
F
T
SM
Y
P
M
V
L
DMKH
A
D
D
L
G
Y
Q
L
K
Q
M
K
E
D
I
R
HVPNKG
V
G
Y
G
I
L
R
Y
LTAPEHKE
D
V
A
F
S
IQPD
V
S
F
N
Y
LGQFDEMSDAGLFTRSELPSGQSLSPETEKPN
A
L
D
V
V
G
Y
I
EN
G
K
L
T
M
S
L
A
YHS
L
E
F
H
E
K
T
V
Q
T
F
S
D
S
F
K
A
H
L
L
R
I
I
E
H
C
L
SQDGTELTPSDLGDDDL
T
L
D
E
L
D
K
L
M
E
IF
1
PsiBlast_PDB
65.80
35%
-97
- C2 -
2VSQ
2
SRFAC_BACSU
A:
[43-1161]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
S
L
N
I
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
E
I
DLTHLT
G
S
E
Q
T
A
K
I
----
N
---
E
Y
-
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
-----
P
P
V
K
-
P
Y
K
D
Y
I
K
W
L
E
K
Q
D
K
Q
A
S
L
R
---
Y
W
R
E
Y
L
E
G
-
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
EI
K
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
Q
P
K
L
I
D
H
I
I
V
F
E
N
-
Y
P
L
Q
D
A
K
N
E
E
S
S
-----
E
N
G
F
D
M
-
V
D
V
H
V
F
E
K
S
N
Y
D
L
N
L
M
A
S
P
G
D
E
M
L
-
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
A
H
-
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
-
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
H
Q
E
M
K
E
Q
A
A
E
L
P
Y
T
G
-
T
T
L
F
I
D
D
Q
T
R
F
E
E
Q
--
A
S
D
P
A
T
A
I
D
P
N
-
D
P
A
Y
I
M
Y
T
S
G
T
------------
T
G
K
P
K
G
N
I
T
T
H
A
N
I
--
Q
G
L
V
K
-
H
V
D
--
Y
M
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
L
L
T
D
----
A
G
E
D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
A
L
R
I
M
G
P
-
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
-
A
H
V
V
--
H
D
L
P
D
---
S
I
S
S
L
P
I
G
K
P
I
S
-
N
A
S
V
Y
I
L
N
E
Q
S
Q
-
L
Q
-
P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
K
-
P
G
-
E
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
E
S
G
D
A
S
I
N
A
Y
L
V
N
R
T
Q
L
S
A
E
D
-----
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
-
L
P
K
P
D
Q
D
-
Q
L
A
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
-
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
-
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
S
D
G
L
Q
D
V
T
I
M
N
Q
D
Q
E
Q
I
I
F
A
F
P
P
V
L
G
Y
G
L
MY
Q
N
L
S
S
R
L
P
S
Y
K
L
C
A
F
D
F
I
E
-----
E
E
D
R
L
-
D
R
Y
A
D
L
I
Q
K
L
--
Q
P
E
G
P
L
T
L
F
G
Y
S
A
G
-----------
C
S
L
A
--
F
E
A
A
---
K
K
L
E
E
----
Q
G
R
-
I
V
-
Q
R
I
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
64.39
36%
-92
- C2 -
2VSQ
2
SRFAC_BACSU
A:
[7-1060]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
E
I
--------
D
L
T
H
L
T
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
------
N
A
L
R
E
Q
K
P
Y
S
L
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
Q
D
---
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
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L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
EI
K
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
------
Q
P
K
L
I
D
H
I
I
V
F
E
N
Y
P
L
Q
D
A
K
NEESS
E
N
G
F
D
M
V
D
-
V
H
V
F
E
K
S
N
Y
D
L
N
L
M
A
S
-
P
G
D
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
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Q
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------------
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G
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---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
62.96
29%
-94
- C2 -
4ZXH
3
?
A:
[11-1048]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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--------------
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-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
58.20
40%
-109
- C2 -
1AMU
4
GRSA_ANEMI
A:
[17-530]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
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----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
56.72
27%
-101
- C2 -
4ZXH
3
?
A:
[14-1047]
--
L
S
R
H
A
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H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
Q
F
E
A
L
R
G
K
A
T
D
-
Y
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
T
Q
T
E
L
M
D
G
L
N
V
S
V
----
P
R
L
D
I
N
Q
A
G
--
V
V
A
L
E
Q
V
R
E
T
L
A
F
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
Q
V
--
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
K
S
I
N
V
L
Q
A
T
P
A
T
W
K
M
L
L
D
S
E
-
W
S
G
N
A
G
L
T
A
L
C
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
K
V
------
G
C
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
A
A
R
I
T
D
-----
A
K
Y
I
D
L
G
E
P
L
A
N
T
Q
L
Y
V
L
D
E
Q
Q
R
L
V
P
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
L
P
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
L
V
K
T
T
G
D
N
D
Q
K
L
V
A
Y
V
T
G
Q
E
---
L
D
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
I
F
E
Q
S
--
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
56.57
26%
-83
- C2 -
4ZXJ
1
ENTF_ECOLI
A:
[2-1041]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
V
A
A
Q
P
G
I
W
M
A
--
E
K
L
S
E
L
P
S
A
W
S
V
A
H
Y
V
E
L
T
-----
G
E
V
D
S
-
P
L
L
A
R
A
V
V
A
G
L
A
Q
A
D
T
L
R
M
R
F
T
E
D
N
G
E
V
W
Q
W
V
D
D
A
L
T
F
E
L
P
E
I
I
D
L
R
TNI
D
PH
G
T
----
A
Q
A
L
M
Q
-
A
D
L
Q
Q
D
L
R
V
D
S
G
K
P
L
V
F
H
Q
L
I
Q
V
A
D
N
R
W
Y
W
Y
Q
R
Y
H
H
L
L
V
D
G
F
S
F
P
A
I
T
R
Q
I
A
N
I
Y
C
--
T
W
L
R
GE
P
--
T
P
A
S
P
F
T
P
F
A
D
V
V
E
E
Y
Q
Q
Y
R
E
S
E
A
W
Q
R
D
A
A
F
---
W
A
E
Q
R
R
Q
L
P
P
P
A
S
L
S
P
A
P
L
P
G
R
S
A
S
A
D
I
L
R
L
K
L
E
F
T
D
G
--
E
F
R
Q
L
A
T
Q
L
S
G
V
Q
R
T
D
L
A
L
A
L
A
A
L
W
L
G
R
L
C
N
R
M
D
Y
A
A
G
F
I
F
M
R
R
L
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A
A
L
T
A
T
G
P
V
L
N
V
L
P
L
G
I
H
I
A
A
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E
T
L
P
E
L
A
T
R
L
A
A
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L
K
K
M
R
R
H
Q
R
Y
D
A
E
Q
I
V
R
D
S
G
R
--
A
A
G
D
E
P
L
F
G
P
V
L
N
I
K
V
F
D
Y
Q
L
---------------
D
--------------
I
P
D
V
Q
A
Q
T
H
T
-
L
A
T
G
P
V
N
D
L
E
L
-
A
L
F
P
-
D
V
H
G
D
L
S
I
E
I
L
A
N
K
Q
R
Y
D
E
P
T
L
I
Q
H
A
E
R
L
K
M
L
I
A
Q
F
A
A
D
P
A
L
L
C
G
D
V
D
I
M
L
P
G
E
Y
A
Q
L
-
A
Q
L
N
A
T
Q
V
E
-
I
P
E
T
T
L
S
A
L
V
A
E
Q
A
A
K
---
T
P
D
A
P
A
L
A
D
A
R
Y
L
F
S
Y
R
E
M
R
E
Q
V
V
A
L
A
N
L
L
R
E
R
G
V
K
P
G
D
S
V
A
V
A
L
P
R
S
V
F
L
T
L
A
L
H
A
I
V
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A
G
A
A
W
L
P
L
D
T
G
Y
P
D
D
R
L
K
M
M
L
E
D
A
R
P
S
L
L
I
-------
T
T
D
------
D
------
Q
L
P
R
--
F
S
D
V
P
N
L
T
S
L
C
Y
N
A
-----
P
L
-
T
P
Q
G
S
A
P
L
Q
L
S
Q
P
H
H
T
A
Y
I
I
F
T
S
G
S
T
G
R
P
K
G
V
M
V
G
Q
T
A
I
V
N
R
L
L
W
M
Q
N
H
Y
P
L
T
G
E
D
V
V
A
Q
K
T
P
C
S
F
D
V
S
V
W
E
F
F
W
P
F
I
A
G
A
K
L
V
M
A
E
P
E
A
H
R
D
P
L
A
M
Q
Q
F
F
A
E
Y
G
V
T
T
T
H
F
V
P
S
M
L
A
A
F
V
A
S
LT
P
Q
T
A
R
Q
S
-----
C
A
T
L
K
Q
V
F
C
S
G
E
A
L
-----
P
A
D
L
C
R
E
W
Q
Q
L
T
-
G
A
P
L
H
N
L
Y
G
P
T
E
A
A
V
D
V
S
W
Y
P
A
F
G
E
E
L
A
Q
V
R
G
S
S
V
P
I
G
Y
P
V
W
N
T
G
L
R
I
L
D
A
M
M
H
P
V
P
P
G
V
A
G
D
L
Y
L
T
G
I
Q
L
A
Q
G
Y
L
G
R
P
D
L
T
A
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R
F
I
A
D
P
F
A
-
P
G
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-
R
M
Y
R
T
G
D
V
A
R
W
-
L
D
N
G
A
V
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Y
L
G
R
S
D
D
Q
L
K
I
R
G
Q
R
I
E
L
G
E
I
D
R
V
M
Q
A
L
P
D
V
E
Q
A
V
T
H
A
C
VINQAA
A
T
G
G
D
A
-
R
Q
L
V
G
-
Y
L
V
S
Q
-
S
GLP
L
D
T
S
A
L
Q
A
Q
L
R
E
T
L
P
P
H
M
V
P
V
V
L
L
Q
L
P
Q
L
P
L
S
A
N
G
K
L
D
R
K
A
L
P
--
L
P
E
L
K
A
-
Q
A
P
G
R
A
P
K
A
G
S
E
T
I
I
A
A
A
F
S
S
L
L
G
C
D
V
Q
D
A
D
A
D
F
F
A
L
G
G
H
S
L
L
A
M
K
L
A
A
Q
L
S
R
Q
-
V
A
R
Q
V
T
P
G
Q
V
M
V
A
S
T
V
A
K
L
A
T
I
I
-
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
55.94
39%
-93
- C2 -
5ES8
1
LGRA_BREPA
A:
[201-767]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
K
A
N
G
A
C
----
D
I
I
D
V
H
D
P
D
S
Y
S
E
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
--
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
Q
M
---
D
N
Q
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
-----
E
R
-----
N
G
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
D
K
----
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
--
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
E
Q
A
D
G
R
K
Y
L
V
G
Y
Y
V
A
P
E
E
--
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
----------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
55.78
42%
-109
- C2 -
1AMU
4
GRSA_ANEMI
A:
[29-530]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
K
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
-
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
L
I
H
N
I
Q
F
N
G
-
Q
V
E
I
F
E
E
D
T
I
K
I
R
E
--
G
T
N
L
H
V
P
S
K
S
T
-
D
L
A
Y
V
I
Y
T
S
-----------------
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
-
E
-
N
--
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
Y
---
V
V
H
----
L
D
P
E
R
I
L
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
K
V
----
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
T
--
K
E
T
I
G
---
H
--
S
V
P
I
G
A
P
I
Q
-
N
T
Q
I
Y
I
V
D
E
N
L
Q
-
L
K
-
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
-
P
G
-
E
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
D
H
Q
E
Q
P
Y
L
C
A
Y
F
V
S
E
K
H
I
P
L
E
Q
-----
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
-
L
P
E
P
D
L
T
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
54.35
42%
-108
- C2 -
1AMU
4
GRSA_ANEMI
B:
[29-530]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
K
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
-
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
L
I
H
N
-
Q
F
N
G
-
Q
V
E
I
F
E
E
D
T
I
K
I
R
E
--
G
T
N
L
H
V
P
S
K
S
T
-
D
L
A
Y
V
I
Y
T
-----------------
N
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
-
E
-
N
--
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
Y
---
V
V
H
----
L
D
P
E
R
I
L
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
K
V
----
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
T
--
K
E
T
I
G
---
H
--
S
V
P
I
G
A
P
I
Q
-
N
T
Q
I
Y
I
V
D
E
N
L
Q
-
L
K
-
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
-
P
G
-
E
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
D
H
Q
E
Q
P
Y
L
C
A
Y
F
V
S
E
K
H
I
P
L
E
Q
-----
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
-
L
P
E
P
D
L
T
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
53.83
30%
-93
- C2 -
4ZXH
3
?
A:
[17-1103]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
I
S
S
E
Q
L
G
I
W
Y
I
--
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
QSL
G
N
K
P
I
-
E
I
L
E
A
V
M
H
D
----
Y
P
L
L
R
V
S
M
P
A
N
D
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
I
-
F
S
D
A
R
---
H
--
I
E
A
S
D
L
T
Q
L
-
V
E
-
Q
D
T
K
Q
P
F
D
L
T
-
Q
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
LV
A
E
----
S
--
D
-
A
V
N
G
I
E
F
V
Q
Y
A
D
K
Q
Q
----
S
S
V
I
D
D
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
R
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
K
R
D
G
S
I
N
P
L
A
Q
I
G
M
F
W
E
R
L
G
G
M
D
EFKELLLPIQTP
A
T
L
V
--------------
G
Q
D
L
T
L
G
S
F
P
V
R
Q
Q
E
G
Q
L
D
I
T
L
E
M
G
G
E
-
Y
-
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
Q
F
E
A
L
R
G
K
A
----
T
D
Y
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
-------
T
Q
T
ELMDGL
N
------
V
S
V
P
R
L
D
I
N
Q
A
G
V
V
A
L
E
Q
V
R
E
T
L
A
F
----------------
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
--
N
A
K
S
I
N
V
L
Q
A
T
P
A
T
W
K
M
L
L
--------
D
S
EWSG
N
A
G
L
T
A
L
-
C
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
------
K
-
V
G
C
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
A
A
R
I
-------
T
D
A
K
Y
I
D
L
G
E
P
L
A
N
T
Q
L
Y
V
L
D
E
Q
Q
R
L
V
P
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
L
-
P
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
-
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
L
-
V
------
K
T
T
G
D
N
D
Q
K
L
V
A
-
Y
V
T
G
Q
-
E
---
L
D
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
--
E
P
I
F
E
Q
-
S
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
-
K
A
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
K
E
I
K
P
S
---------
I
V
I
E
L
R
R
G
T
Y
E
Q
P
L
W
L
F
H
P
I
G
G
S
T
F
C
Y
M
E
L
S
R
H
L
N
P
N
R
T
L
R
A
I
Q
S
PG
L
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
53.50
30%
-94
- C2 -
4ZXI
5
?
A:
[17-1103]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
I
S
S
E
Q
L
G
I
W
Y
I
--
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
QSL
G
N
K
P
I
-
E
I
L
E
A
V
M
H
D
----
Y
P
L
L
R
V
S
M
P
A
N
D
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
I
-
F
S
D
A
R
---
H
--
I
E
A
S
D
L
T
Q
L
-
V
E
-
Q
D
T
K
Q
P
F
D
L
T
-
Q
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
LV
A
E
----
S
--
D
-
A
V
N
G
I
E
F
V
Q
Y
A
D
K
Q
Q
----
S
S
V
I
D
D
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
R
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
K
R
D
G
S
I
N
P
L
A
Q
I
G
M
F
W
E
R
L
G
G
M
D
EFKELLLPIQTP
A
T
L
V
--------------
G
Q
D
L
T
L
G
S
F
P
V
R
Q
Q
E
G
Q
L
D
I
T
L
E
M
G
G
E
-
Y
-
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
Q
F
E
A
L
R
G
K
A
----
T
D
Y
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
-------
T
Q
T
ELMDGL
N
------
V
S
V
P
R
L
D
I
N
Q
A
G
V
V
A
L
E
Q
V
R
E
T
L
A
F
----------------
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
--
N
A
K
S
I
N
V
L
Q
A
T
P
A
T
W
K
M
L
L
--------
D
S
EWSG
N
A
G
L
T
A
L
-
C
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
------
K
-
V
G
C
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
A
A
R
I
-------
T
D
A
K
Y
I
D
L
G
E
P
L
A
N
T
Q
L
Y
V
L
D
E
Q
Q
R
L
V
P
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
L
-
P
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
-
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
L
-
V
------
K
T
T
G
D
N
D
Q
K
L
V
A
-
Y
V
T
G
Q
-
E
---
L
D
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
--
E
P
I
F
E
Q
-
S
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V
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D
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I
E
L
C
T
T
F
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Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
-
K
A
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
K
E
I
K
P
S
---------
I
V
I
E
L
R
R
G
T
Y
E
Q
P
L
W
L
F
H
P
I
G
G
S
T
F
C
Y
M
E
L
S
R
H
L
N
P
N
R
T
L
R
A
I
Q
S
PG
L
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
53.36
43%
-87
- C2 -
5ES8
1
LGRA_BREPA
A:
[202-768]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
---
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
-------
T
N
A
------
L
------
H
E
E
K
--
A
N
G
A
C
D
I
I
D
V
H
D
P
D
S
-----
Y
-
S
E
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
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V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
Q
M
--------
D
-----
N
Q
S
F
R
V
V
I
T
G
G
D
V
L
-----
K
K
I
E
R
N-----
G
-
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
D
------
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
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G
L
G
R
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Y
L
N
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A
E
K
F
I
V
H
P
Q
--
T
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E
-
R
M
Y
R
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G
D
R
A
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F
-
L
P
D
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N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
------
E
Q
A
D
G
R
-
K
Y
L
V
G
-
Y
Y
V
A
P
E
E
---
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
--
D
V
---------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
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M
G
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D
H
F
L
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G
G
D
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V
M
Q
L
I
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Q
L
K
-
N
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L
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L
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P
T
I
R
Q
L
K
R
L
L
-
T
E
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
51.92
32%
-103
- C2 -
4DG9
1
?
A:
[28-594]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
-
R
F
G
S
V
D
Y
R
Q
L
L
D
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A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
T
T
P
T
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A
N
G
L
P
C
V
P
-
V
R
H
L
P
-------
A
A
--
P
A
S
V
A
R
P
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
------------
T
G
R
P
K
A
I
A
C
T
H
A
G
I
--
T
R
L
C
L
-
G
Q
S
--
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
-
N
D
L
G
P
L
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P
G
V
L
R
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L
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R
G
A
D
S
A
W
L
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A
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L
F
N
T
L
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D
----
L
D
P
D
C
L
G
G
L
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L
L
T
G
G
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A
L
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R
-
L
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D
D
D
L
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---
D
--
D
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A
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-
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L
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F
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G
R
G
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G
Y
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L
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L
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A
L
E
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R
F
R
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G
I
L
D
C
A
L
L
V
R
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R
N
G
V
K
Q
L
L
C
A
-
W
T
G
K
A
D
A
S
P
Q
A
-----
L
----
L
R
Q
L
P
T
W
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P
H
A
C
V
R
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A
L
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L
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A
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A
A
L
L
R
R
L
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---------
L
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---
D
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R
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C
A
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L
W
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L
L
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-
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F
F
L
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S
L
L
A
L
Q
L
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A
L
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A
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A
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A
N
L
G
L
A
D
L
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A
N
S
R
L
D
Q
F
S
R
L
L
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
50.82
36%
-118
- C2 -
4D56
5
?
A:
[28-516]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
---------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
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-
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Q
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Q
L
T
Y
E
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L
N
T
K
A
N
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L
A
H
Y
L
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L
G
V
K
S
E
T
L
V
G
V
C
V
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R
S
L
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M
V
I
G
L
L
A
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L
K
A
G
G
A
Y
V
P
L
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Y
P
R
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R
L
T
Y
M
V
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L
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T
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W
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L
I
--
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D
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G
-
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A
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Q
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N
L
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N
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V
N
P
E
-
N
L
A
Y
V
I
Y
T
S
G
S
------------
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
--
V
N
F
T
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L
A
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A
--
Q
Y
Q
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T
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F
D
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A
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C
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L
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T
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A
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-
L
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L
--
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Q
L
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Q
R
N
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I
P
I
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K
S
L
G
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I
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V
Y
V
L
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L
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-
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G
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A
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L
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R
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-------
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L
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A
Y
L
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---
S
T
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N
L
T
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T
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L
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K
L
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S
Y
M
I
P
A
T
F
V
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
50.65
32%
-111
- C2 -
4DG8
3
?
A:
[28-515]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
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D
-
R
F
G
S
V
D
Y
R
Q
L
L
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A
E
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L
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D
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L
L
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Y
P
Q
P
G
V
C
L
G
V
Y
G
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Y
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R
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S
I
T
C
L
L
A
I
L
L
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G
H
H
Y
L
Y
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D
L
K
Q
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A
A
W
N
A
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L
C
R
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V
D
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R
L
I
L
D
C
S
T
T
P
T
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A
N
G
L
P
C
V
P
-
V
R
H
L
P
-------
A
A
--
P
A
S
V
A
R
P
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
------------
T
G
R
P
K
A
I
A
C
T
H
A
G
I
--
T
R
L
C
L
-
G
Q
S
--
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
-
N
D
L
G
P
L
D
P
G
V
L
R
Q
L
I
G
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R
G
A
D
S
A
W
L
T
A
S
L
F
N
T
L
V
D
----
L
D
P
D
C
L
G
G
L
R
Q
L
L
T
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G
D
I
L
S
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A
L
L
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-
L
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L
V
N
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Y
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T
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T
C
-
C
H
V
V
T
D
D
D
L
E
E
---
D
--
D
I
P
I
G
K
A
I
A
-
G
T
A
V
L
L
L
D
E
H
G
Q
E
I
A
-
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
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F
V
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P
Y
R
-
G
R
L
L
R
A
Y
R
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G
D
R
A
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G
R
L
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F
I
G
R
G
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G
Q
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L
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A
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A
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L
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N
G
V
K
Q
L
L
C
A
-
W
T
G
K
A
D
A
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P
Q
A
-----
L
----
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
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L
T
----
L
D
R
A
A
L
L
R
R
L
E
E
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.47
43%
-97
- C2 -
5ES5
1
LGRA_BREPA
A:
[200-683]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
---
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
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A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
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S
L
D
M
I
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S
I
L
A
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M
K
A
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G
A
Y
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I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
ALHEE
K
A
N
------
G
A
C
D
I
I
D
V
H
D
P
--
D
S
Y
S
------------------
E
N
T
N
N
L
P
H
V
N
-
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
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R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
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Y
L
P
T
G
A
A
E
Q
F
M
Q
M
--------
D
-----
N
Q
S
F
R
V
V
I
T
G
G
D
V
L
-----
K
K
I
E
R
------
N
G
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
D
------
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
T
--
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
-
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
------
E
Q
A
D
G
R
-
K
Y
L
V
G
Y
Y
V
A
P
E
-
E
---
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
50.39
29%
-90
- C2 -
2VSQ
2
SRFAC_BACSU
A:
[10-1059]
--
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
----
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
E
I
D
L
T
H
L
T
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
-------
Q
D
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
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L
A
K
S
Q
H
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T
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S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
EI
K
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
------
Q
P
K
L
I
D
H
I
I
V
F
E
N
Y
P
L
Q
D
A
K
N
EESSE----
N
G
F
D
M
V
D
V
H
---
V
F
---
E
K
S
N
Y
D
L
-
N
L
M
A
---
S
P
G
D
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
-
A
H
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
H
Q
E
M
K
E
Q
A
A
E
-
L
PYT
G
T
T
L
F
I
D
D
Q
T
R
F
E
E
Q
A
S
D
P
A
T
A
I
D
P
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
H
V
D
-
Y
M
A
F
--
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
L
L
T
D
A
G
E
D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
A
L
R
I
M
----
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
V
V
H
D
L
-
P
D
S
I
S
S
L
P
I
G
K
P
I
S
N
A
S
V
Y
I
L
N
E
Q
S
Q
L
Q
P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
K
-
P
G
E
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
E
S
G
D
A
S
I
N
A
Y
L
V
N
R
T
Q
--
L
S
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
Q
L
-
A
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
49.86
36%
-115
- C2 -
4D57
5
?
A:
[28-516]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
---------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
W
S
N
L
I
--
S
D
Y
Q
G
-
Q
V
I
C
L
D
S
Q
W
A
K
I
A
S
YS
Q
E
N
L
V
N
T
V
N
P
E
-
N
L
A
Y
V
I
Y
T
S
G
S
------------
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
--
V
N
F
T
K
L
A
I
A
--
Q
Y
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
L
P
D
S
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
A
V
S
-
L
C
R
L
--
S
Q
L
T
E
S
Q
R
N
R
T
E
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
L
K
-
T
V
-
P
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
F
S
-
P
S
-
E
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
-------
R
L
V
A
Y
L
V
P
H
---
S
T
E
E
N
L
T
V
T
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
49.73
43%
-84
- C2 -
5ES8
1
LGRA_BREPA
B:
[200-762]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
---
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
TNALHEE
K
A
N
------
G
ACDIID
V
H
D
P
--
D
S
Y
S
------------------
E
N
T
N
N
L
P
H
V
N
-
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
Q
M
--------
D
-----
N
Q
S
F
R
V
V
I
T
G
G
D
V
L
-----
K
K
I
E
R
------
N
G
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
D
------
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
T
--
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
-
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
------
E
Q
A
D
G
R
-
K
Y
L
V
G
Y
Y
V
A
P
E
-
E
---
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
DV
Q
A
D
A
E
L
L
--
D
Y
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
-
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.63
43%
-86
- C2 -
5ES8
1
LGRA_BREPA
A:
[200-762]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
---
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
ALHEE
K
A
N
------
G
A
C
D
I
I
D
V
H
D
P
--
D
S
Y
S
------------------
E
N
T
N
N
L
P
H
V
N
-
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
Q
M
--------
D
-----
N
Q
S
F
R
V
V
I
T
G
G
D
V
L
-----
K
K
I
E
R
------
N
G
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
D
------
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
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L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
T
--
G
E
-
R
M
Y
R
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G
D
R
A
R
F
L
P
D
-
G
N
I
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L
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L
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G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
------
E
Q
A
D
G
R
-
K
Y
L
V
G
Y
Y
V
A
P
E
-
E
---
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
DV-----------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
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D
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M
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-
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-
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L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
48.56
30%
-107
- C2 -
4DG8
3
?
A:
[26-515]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
T
V
V
A
R
F
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A
A
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--
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---
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C
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--
P
A
A
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--
A
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A
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A
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-
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A
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I
N
F
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S
G
T
------------
T
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A
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A
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--
T
R
L
C
L
-
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--
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----
L
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G
L
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Q
L
L
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G
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G
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T
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--
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D
D
D
L
---
E
E
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D
I
P
I
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A
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L
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L
R
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G
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L
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L
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L
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A
L
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R
F
R
R
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G
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L
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C
A
L
L
V
R
E
R
N
G
V
-
K
Q
L
L
C
A
W
T
G
K
----
A
D
A
-----
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
-
L
L
R
R
L
E
E
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------