@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03510: (2016-06-06 )
MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKGSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQRKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYVPLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMASPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFLLTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQKHGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLSAEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNEMEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAPTIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEILLEFLNTQTVTVS
Atome Classification :
(25 SA)
.........10........20........30....--....40........-50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180...----....190.---......200----.....-..210.......220........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......-----340..------....--.350-------....---..-----------.360....---------...370.......-380-.......390--.......400.......410.......420.......430.......440.....-..450.......460...--....470.......480...-....490.......500.......510.......520.......530.......540.......550.......560.......570.----......580-.......--.590......----.600....----...--------------610.......620.......-630..-.-.-.-..-640.........650.......660.......670.......680.......690.......700......-----.710.----.----.....720--.........730......---.740....-...750.......760.....--..770-.---..-....780..-.....790...-.--..-.800.......810.......820.......830...-...-..--840.......850.......860.......870.......880.......890.-----......900.......--.910.......--.--.920.......930.......940.......950...--....960........970.......980.......990.......1000......1010......1020......1030......---1040.....-.1050....-..1060......1070......1080...-----------....1090....-------.....1100......1110......1120......1130......1140......1150......1160.----.....1170---------.---.....---..1180----.--------......1190......1200......1210......1220......1230......1240......1250......1260......1270..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQF
S
K
D
Q
V
Q
D
M
Y
Y
L
S
P
M
QEG
M
L
F
H
A
ILNPG
Q
S
F
Y
--
L
E
Q
I
T
M
K
VKGSL
N
I
-
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
VK
R
P
V
Q
V
V
L
K
K
R
QF
H
I
E
E
I
D
L
T
HLTGSEQT
A
K
I
N
E
Y
K
E
Q
DKIRGFDLTRDI
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
SY
H
H
I
I
LDG
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
EQKPYSLPPVK
P
Y
K
D
----
Y
I
K
W
L
E
KQ---D
K
Q
A
S
L
R
Y
W
----
R
E
Y
L
E-GFEGQ
T
T
F
A
E
Q
R
K
K
-QKDGY
E
P
K
E
L
L
F
S
L
S
E
A
E
T
K
A
F
T
E
L
A
KSQH
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
QQSGD
L
A
F
G
T
VVSGRPAEIK
G
V
E
H
M
V
G
L
F
I
N
VVP
R
R
V
KLSEGI
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
QSEPH
Q
Y
V
P
L
YDI-----QSQAD------QPK
L
--
I
D
H
I
-------
I
V
FE---NY-----------PLQDAKNE---------ESSENG
F
D
M
V
D
V
H
-
V
F
E-KSNY
D
L
N
L
MA--SPGD
E
M
L
I
K
L
AYNEN
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
IQNPDQPV
S
T
I
NLVDDRE
R
-
E
F
L
LTGLNPPAQAHETK
P
--
L
T
Y
W
F
K
E
AVNANPDA
P
A
L
T
Y-SGQT
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
HGAGKG
S
V
V
A
L
Y
TKR
S
L
E
L
V
I
G
I
L
G
V
L
K
AG
A
A
YLPVDPKL
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
H
Q
E
M
K
E
----
Q
A
AELPYT--G
T
T
L
F
ID--DQ
T
R
F
E
E
QAS----DPATAIDP----ND
P
--------------
A
Y
I
M
YTSGTTGKPKGN
I
T
T
H
-
A
N
I
Q
G
-
L
-
V
-
K
-
H
V
-
D
--
Y
M
AFSDQD
T
F
L
S
VSN
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
ADEHTLL
D
T
E
R
L
T
D
L
I
L
QENV
N
V
M
F
A
T
T
A
L
F
-----
N
L
L
T
D----A----
G
E
D
W
M
K
----
G
L
R
C
I
LFGGERAS
V
P
H
V
R
---
K
A
L
R
IMGP-G
K
L
I
N
C
YGPTE
G
T
V
F
A
T
A
H
V
V
--
H
DL
P
D
-
S
---
I
S-SLPIGKPIS-N
A
S
V
Y
I
LNEQS-Q--LQ-P
F
G
A
V
G
E
L
C
I
SGMGVSKGYV
N
R
A
DL
T
K
E
K
F
IE-NPFK-PGE-
T
L
--YRTG
D
L
A
R
WLPDG
T
I
E
YAGRID
D
Q
V
K
IRG
H
R
I
E
L
E
E
I
E
K
Q
L
Q
EYPGVK
D
A
V
V
V
A
-----DRHESGDA-
S
I
N
A
Y
L
V
--NR--TQL
S
A
E
D
--
V
--
K
A
H
L
K
K
QL
P
A
Y
MV
P
Q
T
F
T
F
L
D
ELPLTTNGKVNKRLLP--KP
D
Q
D
-
Q
L
A
E
E
WIG
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
LGRKQIGIHD
D
F
F
A
LGGH
S
L
K
A
M
T
A
A
S
R
I
K
K
E
LGIDL
P
V
K
L
LFEAP
T
I
A
G
I
S
A
Y
L
---KNGGSDGL
Q
-
D
V
T
I
MNQDQ-
E
Q
I
I
F
AFP
P
V
L
G
Y
G
L
M
Y
Q
N
L
S
S
RL-PS
Y
K
-----------
L
C
A
F
D
---FI
E
E
-------
E
D
R
L
D
R
Y
A
D
L
I
Q
KLQPEG
P
L
T
L
F
GYSAG
C
S
L
A
F
E
A
A
K
K
L
E
E
Q
G
R
I
V
Q
R
I
I
M
V
D
S
Y
K
KQGVSDLDGR
T
V
E
S
----
D
V
E
A
L
M
N-----------V---NRDNE---A
L
N
S
E
-----
A
--------
V
K
H
G
L
K
Q
K
T
H
A
F
Y
S
Y
Y
V
N
L
ISTGQ
V
K
A
D
I
D
L
LTSGADFD
M
P
E
W
L
A
S
W
E
E
ATT
G
V
Y
R
V
K
RGFG
T
H
A
E
M
LQGETLD
R
N
A
E
I
L
L
E
F
LNT
Q
T
V
T
VS
64
HHSearch
64.05
99%
-99
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[1-1274]
M
S
Q
F
S
K
D
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
--
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
E
I
D
L
T
H
L
T
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
P
P
V
K
P
Y
K
D
----
Y
I
K
W
L
E
K
Q
---
D
K
Q
A
S
L
R
Y
W
----
R
E
Y
L
E
-
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
-
Q
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
E
I
K
G
V
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H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
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G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
-----
Q
S
Q
A
D
------
Q
P
K
L
--
I
D
H
I
-------
I
V
F
E
---
N
Y
-----------
P
L
Q
D
A
K
N
E
---------
E
S
S
E
N
G
F
D
M
V
D
V
H
-
V
F
E
-
K
S
N
Y
D
L
N
L
M
A
--
S
P
G
D
E
M
L
I
K
L
A
Y
N
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N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
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N
L
V
D
D
R
E
R
E
F
L
L
T
G
-
L
N
P
P
A
Q
A
H
E
T
K
P
--
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
-
S
G
Q
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K
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G
A
G
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G
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L
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L
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S
A
A
A
C
L
L
T
H
Q
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M
K
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----
Q
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Y
T
--
G
T
T
L
F
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D
--
D
Q
T
R
F
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E
Q
A
S
----
D
P
A
T
A
I
D
P
----
N
D
P
--------------
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
-
A
N
I
Q
G
-
L
-
V
-
K
-
H
V
-
D
--
Y
M
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F
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A
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M
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N
A
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L
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R
L
T
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L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
-----
N
L
L
T
D
----
A
----
G
E
D
W
M
K
----
G
L
R
C
I
L
F
G
G
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A
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V
P
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V
R
---
K
A
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R
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M
G
P
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G
K
L
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N
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Y
G
P
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A
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A
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V
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--
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D
L
P
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-
S
---
I
S
-
S
L
P
I
G
K
P
I
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A
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N
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Q
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-
Q
--
L
Q
-
P
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G
A
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G
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P
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A
R
W
L
P
D
G
T
I
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A
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Q
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K
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R
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H
R
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L
E
E
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K
Q
L
Q
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Y
P
G
V
K
D
A
V
V
V
A
-----
D
R
H
E
S
G
D
A
-
S
I
N
A
Y
L
V
--
N
R
--
T
Q
L
S
A
E
D
--
V
--
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
--
K
P
D
Q
D
-
Q
L
A
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
---
K
N
G
G
S
D
G
L
Q
-
D
V
T
I
M
N
Q
D
Q
-
E
Q
I
I
F
A
F
P
P
V
L
G
Y
G
L
M
Y
Q
N
L
S
S
R
L
-
P
S
Y
K
-----------
L
C
A
F
D
---
F
I
E
E
-------
E
D
R
L
D
R
Y
A
D
L
I
Q
K
L
Q
P
E
G
P
L
T
L
F
G
Y
S
A
G
C
S
L
A
F
E
A
A
K
K
L
E
E
Q
G
R
I
V
Q
R
I
I
M
V
D
S
Y
K
K
Q
G
V
S
-----
T
V
E
S
----
D
V
E
A
L
M
N
-----------
V
---
N
R
----------
E
-----
A
--------
V
K
H
G
L
K
Q
K
T
H
A
F
Y
S
Y
Y
V
N
-----
Q
V
K
A
D
I
D
L
L
T
S
G
A
D
F
D
I
P
E
W
L
A
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W
E
E
A
T
T
G
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R
G
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G
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L
Q
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L
D
R
N
A
E
I
L
L
E
F
L
N
T
Q
T
V
T
V
-
1
PsiBlast_PDB
63.99
99%
-99
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[1-1275]
M
S
Q
F
S
K
D
Q
V
Q
D
M
Y
Y
L
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P
M
Q
E
G
M
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G
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L
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---
D
K
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----
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----
N
D
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--------------
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G
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----
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K
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G
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-------
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Y
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P
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----
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L
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-----------
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---
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----------
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--------
V
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L
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L
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T
Q
T
V
T
V
S
9
PsiBlast_PDB
44.77
26%
-92
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[119-1042]
-------------------------------------------------------------------------------------------------------------------------------------
L
I
Q
V
A
D
N
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W
Y
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A
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AE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
41.26
36%
-115
- C1 -
1AMU
4
GRSA_ANEMI
A:
[17-530]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
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A
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I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
Y
V
-----
V
H
L
--D---
P
----
E
R
I
--
L
----
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
---
K
W
K
E
K
V
----
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
--
T
K
-
E
T
-
I
---
G
H
-
S
V
P
I
G
A
P
I
Q
-
N
T
Q
I
Y
I
V
D
E
-
N
L
Q
--
L
K
-
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
-
N
P
F
V
-
P
G
E
-
K
L
--
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
-----
H
K
D
H
Q
E
Q
P
-
Y
L
C
A
Y
F
V
S
E----
K
H
I
P
L
E
Q
--
L
--
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
--
E
P
D
L
T
-
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
41.12
37%
-101
- C1 -
5ES8
1
LGRA_BREPA
A:
[203-768]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
--
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
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Y
P
G
E
R
I
A
Y
M
L
A
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S
S
A
A
I
L
L
T
N
A
L
H
E
E
----
K
A
N
G
A
C
-----
D
I
I
D
V
H
--
D
P
D
S
Y
S
E
N
T
N
----
N
L
P
H
V
N
R
P
----
D
D
L
--------------
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
-
H
N
L
V
N
-
F
-
C
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W
-
Y
R
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P
--
Y
F
G
V
T
P
A
D
K
A
L
V
Y
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S
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S
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S
A
L
D
I
F
T
H
L
L
A
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A
A
L
H
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V
P
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R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
-----
E
Q
F
M
Q
----
M
-------
D
N
Q
----
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
--------
E
-
R
N
G
T
-
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
--
D
K
----
P
---
Y
A
-
N
I
P
I
G
K
P
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D
-
R
T
R
I
L
I
L
D
E
A
L
-
A
--
L
Q
-
P
I
G
V
A
G
E
L
F
I
V
G
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L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
-
H
P
Q
--
T
G
E
-
R
M
--
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
-----
K
E
Q
A
D
G
R
K
-
Y
L
V
G
Y
Y
V
--
A
P
--
E
E
I
P
H
G
E
--
L
--
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
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Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
--
D
V
----------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
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D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
---
T
E
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
41.12
27%
-106
- C1 -
4ZXI
5
?
A:
[12-1165]
-------
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
G
N
-
K
P
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E
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I
L
E
A
V
M
H
D
Y
P
L
L
R
-
V
S
M
P
A
N
D
Q
G
I
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Q
L
I
W
D
R
V
Y
P
N
I
I
F
S
D
A
R
H
I
E
A
S
D
L
T
Q
L
V
----
E
Q
D
T
K
Q
P
F
D
L
T
Q
P
P
L
W
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I
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C
Y
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V
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A
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V
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A
L
M
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L
L
L
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K
R
F
G
L
V
A
E
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A
V
N
G
I
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F
V
Q
Y
A
D
----
K
Q
Q
S
S
V
I
D
---
D
T
D
E
S
L
I
F
W
----
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
-
A
V
Q
Q
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K
G
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G
L
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A
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G
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G
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L
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K
L
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N
N
L
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A
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P
V
A
G
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--
R
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A
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A
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Q
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L
K
H
Q
K
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A
F
S
R
V
------
V
E
A
V
------
S
P
K
R
--
D
G
S
I
NPLAQ
I
G
M
F
W
E
---
R
L
GGMDEFKELLL
P
I
Q
T
P
A
T
L
---------
V
G
Q
D
L
T
L
G
S
F
P
V
R
-
Q
Q
E
G
Q
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D
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G
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--
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A
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A
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G
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L
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G
K
A
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A
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--
L
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A
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N
H
A
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---
H
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V
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G
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A
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A
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A
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Q
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D
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L
M
L
D
R
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A
L
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A
A
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I
W
A
A
G
A
A
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V
P
L
D
P
N
F
P
T
E
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L
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N
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I
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D
A
E
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K
V
I
L
T
Q
T
E
L
M
D
GLNV
S
V
P
R
L
D
I
N
--
Q
A
G
V
V
A
L
--
E
Q
V
R
-------------
E
T
L
A
F
----
G
D
I
--------------
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
-
P
S
I
I
N
F
L
-
L
-
S
-
M
N
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D
--
R
L
Q
V
T
T
E
T
Q
L
L
A
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T
T
Y
A
F
D
I
S
I
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L
L
I
P
L
M
Y
G
G
V
V
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V
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P
R
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S
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D
G
I
Q
L
V
D
Y
L
N
A
K
S
I
N
V
L
Q
A
T
P
A
T
W
-----
K
M
L
L
D
----
S
----
E
W
S
G
N
A
----
G
L
T
A
-
L
C
G
G
E
A
L
D
T
I
L
A
E
---
K
L
L
G
K
V
---
G
C
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
A
A
R
I
--
T
D
--------
A
K
-
Y
I
D
L
G
E
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L
A
-
N
T
Q
L
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V
L
D
E
Q
Q
-
R
--
L
V
-
P
P
G
V
M
G
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L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
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A
Q
F
R
T
-
L
P
S
L
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N
A
G
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Y
R
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D
K
V
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D
G
R
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G
R
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D
F
Q
V
K
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I
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L
G
E
I
E
N
V
L
K
Q
I
D
G
I
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D
A
V
V
L
V
-----
K
T
T
G
D
N
D
Q
-
K
L
V
A
Y
V
T
--
G
Q
---
E
L
D
I
A
G
--
L
--
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
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L
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F
P
M
T
A
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K
K
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K
A
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P
--
E
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I
F
E
-
Q
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D
Y
V
A
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C
T
T
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I
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S
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F
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L
L
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K
A
F
G
T
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V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
---
R
E
N
K
E
I
K
P
S
-
I
V
I
E
L
R
R
G
T
Y
E
Q
P
L
W
L
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P
I
G
G
S
T
F
C
Y
M
E
L
S
R
H
L
N
P
N
R
T
-----------
L
R
A
I
Q
S
PG
L
I
E
A
DAAEVA
I
E
E
M
A
T
L
Y
I
A
E
M
Q
K
M
Q
P
Q
G
P
Y
F
L
G
G
W
C
F
G
G
A
I
A
Y
E
I
S
R
Q
L
R
Q
M
G
Q
Q
V
T
G
I
V
M
I
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
41.00
97%
-135
- C2 -
1JMK
1
O:
[1-230]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
S
D
G
L
Q
-
D
V
T
I
M
N
Q
D
Q
-
E
Q
I
I
F
A
F
P
P
V
L
G
Y
G
L
M
Y
Q
N
L
S
S
R
L
-
P
S
Y
K
-----------
L
C
A
F
D
---
F
I
E
E
-------
E
D
R
L
D
R
Y
A
D
L
I
Q
K
L
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P
L
T
L
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Y
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A
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C
S
L
A
F
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A
A
K
K
L
E
G
Q
G
R
I
V
Q
R
I
I
M
V
D
S
Y
K
K
Q
G
V
S
D
L
D
G
R
T
V
E
S
----
D
V
E
A
L
M
N
-----------
V
---
N
R
D
N
E
---
A
L
N
S
E
-----
A
--------
V
K
H
G
L
K
Q
K
T
H
A
F
Y
S
Y
Y
V
N
L
I
S
T
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Q
V
K
A
D
I
D
L
L
T
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A
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F
D
I
P
E
W
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A
S
W
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A
Y
R
M
K
R
G
F
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H
A
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M
L
Q
G
E
T
L
D
R
N
A
G
I
L
L
E
F
L
N
T
Q
T
----
3
PsiBlast_PDB
40.95
27%
-108
- C1 -
4ZXH
3
?
A:
[12-1165]
-------
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
G
N
-
K
P
I
E
-
I
L
E
A
V
M
H
D
Y
P
L
L
R
-
V
S
M
P
A
N
D
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
I
F
S
D
A
R
H
I
E
A
S
D
L
T
Q
L
V
----
E
Q
D
T
K
Q
P
F
D
L
T
Q
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
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V
S
K
R
F
G
L
V
A
E
S
D
A
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N
G
I
E
F
V
Q
Y
A
D
----
K
Q
Q
S
S
V
I
D
---
D
T
D
E
S
L
I
F
W
----
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
-
A
V
Q
Q
H
K
G
S
S
L
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F
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V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
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E
I
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L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
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--
R
S
L
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A
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------
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------
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--
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NPLAQ
I
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---
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GMDEFKELLL
P
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A
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L
---------
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--
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Q
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-------------
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L
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----
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I
--------------
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----
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P
A
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W
-----
K
M
L
L
D
----
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----
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W
S
G
N
A
----
G
L
T
A
-
L
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G
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L
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---
K
L
L
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---
G
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L
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--
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--------
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---
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L
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A
L
L
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R
L
G
E
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I
---
R
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N
K
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L
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N
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T
-----------
L
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PG
L
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A
DAAEVA
I
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M
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M
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Q
Q
V
T
G
I
V
M
I
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
40.77
35%
-117
- C1 -
4D56
5
?
A:
[36-516]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
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Y
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E
L
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A
N
Q
L
A
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Y
L
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L
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S
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T
L
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G
V
C
V
D
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S
L
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M
V
I
G
L
L
A
I
L
K
A
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G
A
Y
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P
L
D
P
T
Y
P
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L
T
Y
M
V
Q
D
A
Q
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V
L
V
T
Q
T
Q
W
S
N
----
L
I
S
D
--
Y
Q
--
G
Q
V
I
C
L
D
--
S
Q
--
W
A
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I
A
S
YSQE
N
L
V
N
T
V
N
P
----
E
N
L
--------------
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
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-
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L
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N
-
F
-
T
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K
L
A
I
-
A
--
Q
Y
Q
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S
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T
L
Q
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S
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-----
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L
L
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----
K
I
A
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D
----
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R
---
M
W
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-
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A
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-----
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--------
R
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Y
L
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--
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--
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L
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--
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F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
40.71
35%
-115
- C1 -
4D4I
4
?
A:
[36-515]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
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Y
E
E
L
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T
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A
N
Q
L
A
H
Y
L
R
T
L
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S
E
T
L
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V
C
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L
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L
L
A
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L
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A
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A
Y
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D
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Y
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L
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Y
M
V
Q
D
A
Q
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V
L
V
T
Q
T
Q
W
S
N
----
L
I
S
D
--
Y
Q
--
G
Q
V
I
C
L
D
--
S
Q
--
W
A
K
I
A
S
YSQE
N
L
V
N
T
V
N
P
----
E
N
L
--------------
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
-
Q
S
L
V
N
-
F
-
T
-
K
L
A
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-
A
--
Q
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Q
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L
Q
F
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F
D
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A
A
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L
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-----
H
L
L
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N
E
L
V
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----
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A
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D
----
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L
R
L
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G
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P
E
L
V
R
---
M
W
F
K
N
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N
F
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--
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-
S
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N
R
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V
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D
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T
L
-
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--
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P
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I
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G
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A
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A
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R
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F
I
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-
D
P
F
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-
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S
E
-
R
L
--
Y
K
T
G
D
L
G
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Y
L
A
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G
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L
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Y
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L
G
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L
L
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H
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A
Q
A
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V
I
D
-----
R
--------
R
L
V
A
Y
L
V
--
P
H
--
S
T
E
E
N
L
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--
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Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
40.47
35%
-116
- C1 -
4D57
5
?
A:
[36-516]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
T
Y
E
E
L
N
T
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A
N
Q
L
A
H
Y
L
R
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L
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S
E
T
L
V
G
V
C
V
D
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S
L
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M
V
I
G
L
L
A
I
L
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A
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G
A
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Y
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L
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Y
M
V
Q
D
A
Q
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L
V
T
Q
T
Q
W
S
N
----
L
I
S
D
--
Y
Q
--
G
Q
V
I
C
L
D
--
S
Q
--
W
A
K
I
A
S
YSQ
E
N
L
V
N
T
V
N
P
----
E
N
L
--------------
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
-
Q
S
L
V
N
-
F
-
T
-
K
L
A
I
-
A
--
Q
Y
Q
I
T
T
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D
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T
L
Q
F
V
S
I
S
F
D
V
A
A
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E
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T
L
C
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A
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L
I
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M
I
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D
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Q
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A
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-----
H
L
L
V
N
E
L
V
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----
K
I
A
L
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----
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L
R
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G
E
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V
Q
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V
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---
M
W
F
K
N
V
G
N
F
P
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L
I
N
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Y
G
P
T
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G
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A
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L
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--
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Q
L
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-
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V
L
D
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L
-
K
--
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-
P
P
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I
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G
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A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
-
D
P
F
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-
P
S
E
-
R
L
--
Y
K
T
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D
L
G
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Y
L
A
D
G
N
L
E
Y
L
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D
H
Q
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N
G
F
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L
G
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L
L
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A
Q
A
V
V
I
D
-----
R
--------
R
L
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A
Y
L
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--
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--
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T
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E
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L
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--
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T
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Q
F
L
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N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
40.42
25%
-106
- C1 -
4ZXH
3
?
A:
[9-1318]
----
L
E
P
E
V
L
S
R
H
A
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Q
L
G
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W
Y
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N
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----
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I
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H
A
L
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W
S
I
G
L
L
L
R
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S
K
R
F
G
L
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A
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S
D
---
A
V
N
G
I
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F
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Q
----
Y
A
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VID
D
T
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E
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L
I
F
W
----
K
N
A
L
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-
H
A
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S
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L
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N
L
A
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L
F
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L
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L
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L
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N
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R
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L
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L
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H
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K
I
A
F
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V
-----
V
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A
V
S
PKRDGS
I
N
P
L
--
A
Q
I
G
-------
M
F
W
E
---
R
L
-----------
G
G
M
D
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LLLPIQTP
A
T
L
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L
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L
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-
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G
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---
H
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----
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----
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--------------
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----
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-
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-----
K
M
L
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----
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----
E
W
-
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----
A
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G
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---
K
L
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---
G
C
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W
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V
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---
A
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L
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G
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N
V
L
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Q
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D
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I
T
D
A
V
V
L
V
-----
K
T
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D
N
D
Q
-
K
L
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A
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--
G
Q
--
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A
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--
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--
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K
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--
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R
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D
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F
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K
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H
L
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K
A
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A
L
L
A
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R
L
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---
R
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K
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P
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I
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L
R
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-
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-
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N
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T
L
R
A
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PGLI
E
A
D
A
A
---
E
V
A
I
-------
E
E
M
A
T
L
Y
I
A
E
M
Q
K
M
Q
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Q
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F
L
G
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N
V
P
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D
A
D
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A
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L
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A
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PYG
K
K
L
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A
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P
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R
L
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F
D
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Y
L
A
N
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I
A
L
Q
T
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F
P
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-
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D
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P
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L
L
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A
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L
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S
I
M
Y
A
E
N
V
V
A
V
A
Q
T
I
D
Q
M
Y
P
-------
10
PsiBlast_PDB
40.36
35%
-114
- C1 -
4D4G
4
?
A:
[36-514]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
W
S
N
----
L
I
S
D
--
Y
Q
--
G
Q
V
I
C
L
D
--
S
Q
--
W
A
K
I
A
S
YSQ
E
N
L
V
N
T
V
N
P
----
E
N
L
--------------
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
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H
-
Q
S
L
V
N
-
F
-
T
-
K
L
A
I
-
A
--
Q
Y
Q
I
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T
S
D
R
T
L
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F
V
S
I
S
F
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A
A
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V
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I
L
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F
V
Q
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D
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Q
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W
S
L
P
T
A
Y
W
-----
H
L
L
V
N
E
L
V
K
S
----
K
I
A
L
P
D
----
S
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
L
V
R
---
M
W
F
K
N
V
G
N
F
P
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L
I
N
V
Y
G
P
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G
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A
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L
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--
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Q
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-
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N
R
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L
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I
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V
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V
L
D
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T
L
-
K
--
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P
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I
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I
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A
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N
R
P
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A
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S
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--
Y
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T
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Y
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L
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D
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F
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L
G
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I
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V
L
L
Q
H
H
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V
A
Q
A
V
V
I
D
-----
R
--------
R
L
V
A
Y
L
V
--
P
H
--
S
T
E
E
N
L
T
--
V
T
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
40.08
35%
-128
- C1 -
4D4H
1
?
A:
[36-436]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
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G
A
Y
V
P
L
D
P
T
Y
P
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L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
W
S
N
----
L
I
S
D
--
Y
Q
--
G
Q
V
I
C
L
D
--
S
Q
--
W
A
K
I
A
S
YSQE
N
L
V
N
T
V
N
P
----
E
N
L
--------------
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
-
Q
S
L
V
N
-
F
-
T
-
K
L
A
I
-
A
--
Q
Y
Q
I
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T
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D
R
T
L
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F
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S
I
S
F
D
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A
A
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C
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I
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S
I
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F
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S
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D
W
Q
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W
S
L
P
T
A
Y
W
-----
H
L
L
V
N
E
L
V
K
S
----
K
I
A
L
P
D
----
S
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
L
V
R
---
M
W
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
A
V
S
L
C
R
L
--
S
Q
L
T
E
-
S
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N
R
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-
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L
G
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I
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V
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D
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-
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--
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-
P
P
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Y
I
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G
T
A
L
A
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G
Y
L
N
R
P
E
L
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A
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F
I
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-
D
P
F
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-
P
S
E
-
R
L
--
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
39.67
38%
-99
- C1 -
5ES8
1
LGRA_BREPA
A:
[209-757]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
----
K
A
-----
N
--
G
A
C
D
I
I
D
VH
D
P
D
S
Y
S
E
N
T
N
----
N
L
P
H
V
N
R
P
----
D
D
L
--------------
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
-
H
N
L
V
N
-
F
-
C
-
E
W
Y
R
-
P
--
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
------------
L
P
T
G
----
A
----
A
E
Q
F
M
Q
MDNQ
S
F
R
V
V
I
T
G
G
D
------
V
L
---
K
K
I
E
R
N
G
T
-
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
P
------
Y
A
-
N
I
P
I
G
K
P
I
D
-
R
T
R
I
L
I
L
D
E
A
L
-
A
--
L
Q
-
P
I
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V
A
G
E
L
F
I
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G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
-
H
P
-
Q
-
T
G
E
-
R
M
--
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
-----
K
E
Q
A
D
G
R
K
-
Y
L
V
G
Y
Y
V
--
A
P
--
E
E
I
P
H
G
E
--
L
--
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
DV------------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
39.47
37%
-107
- C1 -
1AMU
4
GRSA_ANEMI
A:
[38-530]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
T
--
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
-
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
----
L
I
H
N
I
Q
F
N
--
G
Q
V
E
I
F
E
--
E
D
T
I
K
I
R
E
G
T
----
N
L
H
V
P
S
K
S
----
T
D
L
--------------
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
-
K
G
I
S
N
-
L
-
K
V
F
-
F
E
-
N
--
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
Y
V
-----
V
H
L
D
P
-----------
E
R
I
L
----
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
---
K
W
K
E
---
K
-
V
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
--
T
K
-
E
T
-
I
---
G
H
-
S
V
P
I
G
A
P
I
Q
-
N
T
Q
I
Y
I
V
D
E
N
L
-
Q
--
L
K
-
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
-
N
P
F
V
-
P
G
E
-
K
L
--
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
-----
H
K
D
H
Q
E
Q
P
-
Y
L
C
A
Y
F
V
--
S
E
--
K
H
I
P
L
E
Q
--
L
--
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
--
E
P
D
L
T
-
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
39.06
38%
-96
- C1 -
5ES8
1
LGRA_BREPA
B:
[209-757]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
----
K
A
-----
N
--
G
A
C
D
I
I
D
VH
D
P
D
S
Y
S
E
N
T
N
----
N
L
P
H
V
N
R
P
----
D
D
L
--------------
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
-
H
N
L
V
N
-
F
-
C
-
E
W
Y
R
-
P
--
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
------------
L
P
T
G
----
A
----
A
E
Q
F
M
Q
MDNQ
S
F
R
V
V
I
T
G
G
D
------
V
L
---
K
K
I
E
R
N
G
T
-
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
P
------
Y
A
-
N
I
P
I
G
K
P
I
D
-
R
T
R
I
L
I
L
D
E
A
L
-
A
--
L
Q
-
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
-
H
P
-
Q
-
T
G
E
-
R
M
--
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
-----
K
E
Q
A
D
G
R
K
-
Y
L
V
G
Y
Y
V
--
A
P
--
E
E
I
P
H
G
E
--
L
--
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
DV
Q
A
D
A
E
-
L
L
--
D
Y
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
38.59
38%
-110
- C1 -
5ES9
1
LGRA_BREPA
A:
[209-757]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
----
K
A
-----
N
--
G
A
C
D
I
I
D
VH
D
P
D
S
Y
S
E
N
T
N
----
N
L
P
H
V
N
R
P
----
D
D
L
--------------
V
Y
V
M
Y
T
S
----
L
A
K
G
V
M
I
E
H
-
H
N
L
V
N
-
F
-
C
-
E
W
Y
R
-
P
--
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
------------
L
P
T
G
----
A
----
A
E
Q
F
M
Q
MDNQ
S
F
R
V
V
I
T
G
G
D
------
V
L
---
K
K
I
E
R
N
G
T
-
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
P
------
Y
A
-
N
I
P
I
G
K
P
I
D
-
R
T
R
I
L
I
L
D
E
A
L
-
A
--
L
Q
-
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
-
H
P
-
Q
-
T
G
E
-
R
M
--
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
-----
K
E
Q
A
D
G
R
K
-
Y
L
V
G
Y
Y
V
--
A
P
--
E
E
I
P
H
G
E
--
L
--
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
Q
A
D
A
--------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
38.48
36%
-105
- C1 -
1AMU
4
GRSA_ANEMI
A:
[21-530]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
-
Q
Y
L
F
A
V
N
N
T
K
A
E
Y
P
R
D
K
T
--
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
-
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
----
L
I
H
N
I
Q
F
N
--
G
Q
V
E
I
F
E
--
E
D
T
I
K
I
R
E
G
T
----
N
L
H
V
P
S
K
S
----
T
D
L
--------------
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
-
K
G
I
S
N
-
L
K
V
-
F
-
F
E
-
N
--
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
---
T
L
P
P
-----
T
Y
V
V
H
----
L
----
D
P
E
R
I
L
----
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
---
K
W
K
E
K
V
----
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
----
T
K
E
-
T
---
I
G
H
S
V
P
I
G
A
P
I
Q
-
N
T
Q
I
Y
I
V
D
E
N
L
-
Q
--
L
K
-
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
-
N
P
F
V
-
P
G
E
-
K
L
--
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
-----
H
K
D
H
Q
E
Q
P
-
Y
L
C
A
Y
F
V
--
S
E
--
K
H
I
P
L
E
Q
--
L
--
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
--
E
P
D
L
T
F----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
38.09
36%
-104
- C1 -
1AMU
4
GRSA_ANEMI
B:
[21-530]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
-
Q
Y
L
F
A
V
N
N
T
K
A
E
Y
P
R
D
K
T
--
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
-
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
----
L
I
H
N
-
Q
F
N
--
G
Q
V
E
I
F
E
--
E
D
T
I
K
I
R
E
G
T
----
N
L
H
V
P
S
K
S
----
T
D
L
--------------
A
Y
V
I
Y
T
-----
N
P
K
G
T
M
L
E
H
-
K
G
I
S
N
-
L
K
V
-
F
-
F
E
-
N
--
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
---
T
L
P
P
-----
T
Y
V
V
H
----
L
----
D
P
E
R
I
L
----
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
---
K
W
K
E
K
V
----
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
----
T
K
E
-
T
---
I
G
H
S
V
P
I
G
A
P
I
Q
-
N
T
Q
I
Y
I
V
D
E
N
L
-
Q
--
L
K
-
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
-
N
P
F
V
-
P
G
E
-
K
L
--
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
-----
H
K
D
H
Q
E
Q
P
-
Y
L
C
A
Y
F
V
--
S
E
--
K
H
I
P
L
E
Q
--
L
--
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
--
E
P
D
L
T
F----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
35.74
31%
-105
- C1 -
4DG8
3
?
A:
[25-515]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
P
T
----
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
-
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
T
T
P
T
----
P
A
N
G
L
P
C
V
--
P
V
------------
R
H
L
P
A
----
A
P
A
S
V
A
R
P
C
F
A
A
D
Q
I
--------------
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
-
A
G
I
T
R
-
L
-
C
-
L
-
G
Q
-
S
--
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
P
-
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
-----
N
T
L
V
D
----
L
----
D
P
D
C
L
G
----
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
---
R
A
L
L
R
H
P
R
-
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
--
T
D
D
D
L
-
E
---
E
D
-
D
I
P
I
G
K
A
I
A
-
G
T
A
V
L
L
L
D
E
H
G
-
Q
EI
A
E
-
P
D
R
A
-
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
-
L
P
Y
R
--
G
R
-
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
------
R
E
R
N
G
V
K
-
Q
L
L
C
A
W
T
--
G
K
--
A
D
A
S
P
Q
--------
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
L
--
R
R
L
E
E
-
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
35.17
33%
-97
- C1 -
3VNS
2
?
A:
[37-537]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
-
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
A
S
A
L
I
G
E
P
H
E
G
C
----
A
V
T
R
V
V
R
T
--
A
A
V
A
E
C
K
--
D
A
---
E
P
---------
A
P
G
P
G
A
----
E
D
M
--------------
A
Y
V
I
Y
T
S
G
-
T
G
N
P
K
G
V
P
V
R
H
-
A
N
V
L
A
-
L
-
L
-
A
-
G
A
P
S
--
V
F
D
F
S
G
D
D
R
W
L
L
F
H
S
L
S
F
D
F
S
V
W
E
I
W
G
A
F
S
T
G
A
E
L
V
V
L
P
H
W
A
A
R
T
P
E
Q
Y
L
A
V
I
I
D
R
G
V
T
V
I
N
Q
T
P
T
A
F
-----
L
A
L
T
E
----
A
A
V
R
G
G
R
D
-
V
S
----
G
L
R
Y
V
I
F
G
G
E
K
L
T
A
P
M
L
R
P
W
A
K
A
F
G
L
D
R
P
--
R
L
V
N
G
Y
G
I
T
E
T
T
V
F
T
T
F
E
E
I
--
T
E
A
Y
L
-
A
---
Q
D
-
A
S
I
I
G
R
A
L
P
-
S
F
G
T
R
V
V
G
D
D
G
-
R
--
D
V
-
A
P
G
E
T
G
E
L
W
L
S
G
A
Q
L
A
E
G
Y
L
R
R
P
E
L
T
A
E
K
F
P
E
V----------
V
R
Y
Y
R
T
G
D
L
V
S
E
L
P
D
G
R
F
A
Y
E
G
R
A
D
L
Q
I
K
L
R
G
Y
R
I
E
L
S
D
I
E
T
A
V
R
R
H
D
D
V
V
D
A
V
V
T
V
-----
R
E
F
K
P
G
D
L
-
R
L
V
C
A
Y
V
--
A
R
EG
S
A
T
T
A
R
E
--
L
--
R
N
H
I
K
T
L
L
P
A
Y
M
H
P
A
R
Y
L
P
L
P
G
L
P
R
T
V
N
G
K
V
D
R
A
A
V
A
--
R
S
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
34.86
33%
-98
- C1 -
3VNQ
1
?
A:
[37-537]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
-
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
A
S
A
L
I
G
E
P
H
E
G
C
----
A
V
T
R
V
V
R
T
--
A
A
V
A
E
C
K
--
D
A
---
E
----------
A
P
G
P
G
A
----
E
D
M
--------------
A
Y
V
I
Y
T
S
G
T
T
G
N
P
K
G
V
P
V
R
H
-
A
N
V
L
A
-
L
-
L
-
A
-
G
A
P
S
--
V
F
D
F
S
G
D
D
R
W
L
L
F
H
S
L
S
F
D
F
S
V
W
E
I
W
G
A
F
S
T
G
A
E
L
V
V
L
P
H
W
A
A
R
T
P
E
Q
Y
L
A
V
I
I
D
R
G
V
T
V
I
N
Q
T
P
T
A
F
-----
L
A
L
T
E
----
A
A
V
R
G
G
R
D
-
V
S
----
G
L
R
Y
V
I
F
G
G
E
K
L
T
A
P
M
L
R
P
W
A
K
A
F
G
L
D
R
P
--
R
L
V
N
G
Y
G
I
T
E
T
T
V
F
T
T
F
E
E
I
--
T
E
A
Y
L
-
A
---
Q
D
-
A
S
I
I
G
R
A
L
P
-
S
F
G
T
R
V
V
G
D
D
G
-
R
--
D
V
-
A
P
G
E
T
G
E
L
W
L
S
G
A
Q
L
A
E
G
Y
L
R
R
P
E
L
T
A
E
K
F
P
E
V----------
V
R
Y
Y
R
T
G
D
L
V
S
E
L
P
D
G
R
F
A
Y
E
G
R
A
D
L
Q
I
K
L
R
G
Y
R
I
E
L
S
D
I
E
T
A
V
R
R
H
D
D
V
V
D
A
V
V
T
V
-----
R
E
F
K
P
G
D
L
-
R
L
V
C
A
Y
V
--
A
R
EG
S
A
T
T
A
R
E
--
L
--
R
N
H
I
K
T
L
L
P
A
Y
M
H
P
A
R
Y
L
P
L
P
G
L
P
R
T
V
N
G
K
V
D
R
A
A
V
A
--
R
S
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
34.66
38%
-118
- C1 -
5ES7
2
LGRA_BREPA
A:
[209-585]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
-
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
----
K
A
-----
N
--
G
A
C
D
I
I
D
VH
D
P
D
S
Y
S
E
N
T
N
----
N
L
P
H
V
N
R
P
----
D
D
L
--------------
V
Y
V
M
Y
T
S
-----
A
K
G
V
M
I
E
H
-
H
N
L
V
N
-
F
-
C
-
E
W
Y
R
-
P
--
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
------------
L
P
T
G
----
A
----
A
E
Q
F
M
Q
MDNQ
S
F
R
V
V
I
T
G
G
D
------
V
L
---
K
K
I
E
R
N
G
T
-
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
---
D
K
P
------
Y
A
-
N
I
P
I
G
K
P
I
D
-
R
T
R
I
L
I
L
D
E
A
L
-
A
--
L
Q
-
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
-
H
P
-
Q
-
T
G
E
-
R
M
--
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
34.05
30%
-104
- C1 -
4DG8
3
?
A:
[26-515]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
T
--
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
-
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
T
T
P
T
----
P
A
N
G
L
P
------
C
V
P
V
R
--
H
L
P
A
--
A
P
A
S
----
V
A
R
P
C
F
A
A
----
D
Q
I
--------------
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
-
A
G
I
T
R
-
L
-
C
-
L
-
G
Q
-
S
--
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
-
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
-----
N
T
L
V
D
----
L
----
D
P
D
C
L
G
----
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
---
R
A
L
L
R
H
P
R
-
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
--
T
D
D
D
L
-
E
---
E
D
-
D
I
P
I
G
K
A
I
A
-
G
T
A
V
L
L
L
D
E
H
G
-
Q
--
E
I
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
-
L
P
Y
R
G
R
L
L
-
R
A
--
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
-----
R
E
R
N
G
V
K
--
Q
L
L
C
A
W
T
--
G
K
------
A
D
A
--
S
--
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
L
--
R
R
L
E
E
-
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------