@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03590: (2016-06-06 )
MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLLRCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENVMEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPELMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVIVEQGPPEQIFSAPKEERTQRFLNRILNPL
Atome Classification :
(38 SA)
.........10--...----..--...20........30........40........50........60........------70........-80.-........90........100.......110---.....-----..120......--.130...-..-..140.......150.......160.......170.......180......-.-.-190.......200.......210.......220.......230.......240.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
T
VKGLNKSF--
G
E
N
----
E
I
--
L
K
K
ID
M
K
IEKG
K
V
I
A
I
LGPSGS
G
K
T
T
L
L
R
C
L
N
A
LEIPNRGE
L
A
F
DDFSI
D
F
S
K
------KV
K
Q
A
D
I
L
K
L
-
R
-
R
-KS
G
M
V
F
Q
A
YHLFP
H
R
T
A
L
E
N
V
MEGPV
Q
V
QKR---
N
K
E
E
V
-----
R
K
E
A
I
Q
L
L
D
KV--GLKDKMD-L
Y
-
P
F
QLSGGQ
Q
Q
R
V
G
I
A
R
A
LAIQP
E
L
M
L
FDEPTSAL
D
P
E
L
V
G
E
V
L
K
-
V
I
K
D
L
A
-N-E-G
W
T
M
V
V
V
T
H
E
I
K
F
A
Q
E
VAD
E
V
I
F
IDG
G
V
I
VEQG
P
P
E
Q
I
FSA
P
K
E
E
R
T
Q
R
F
L
N
R
ILNPL
22
PsiBlast_CBE
88.60
59%
-121
- C1 -
4YMU
2
?
A:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
----------
V
N
I
N
K
V
-
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
---
N
K
K
E
A
-----
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---
1
PsiBlast_PDB
87.63
59%
-118
- C1 -
4YMS
-
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
----------
V
N
I
N
K
V
-
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
---
N
K
K
E
A
-----
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---
21
PsiBlast_CBE
86.51
59%
-117
- C1 -
4YMV
1
?
A:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
----------
V
N
I
N
K
V
-
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
---
N
K
K
E
A
-----
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---
3
PsiBlast_PDB
85.58
59%
-117
- C1 -
4YMU
2
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
----------
V
N
I
N
K
V
-
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
---
N
K
K
E
A
-----
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---
5
PsiBlast_PDB
85.33
59%
-117
- C1 -
4YMW
-
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
----------
V
N
I
N
K
V
-
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
---
N
K
K
E
A
-----
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---
4
PsiBlast_PDB
84.88
59%
-120
- C1 -
4YMV
1
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
----------
V
N
I
N
K
V
-
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
---
N
K
K
E
A
-----
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---
2
PsiBlast_PDB
84.69
59%
-117
- C1 -
4YMT
-
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
----------
V
N
I
N
K
V
-
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
---
N
K
K
E
A
-----
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
---
9
PsiBlast_PDB
84.56
55%
-127
- C1 -
2OUK
1
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
7
PsiBlast_PDB
84.31
55%
-128
- C1 -
2OLJ
4
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
30
PsiBlast_CBE
83.70
55%
-123
- C1 -
2OLK
1
?
C:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
27
PsiBlast_CBE
83.16
55%
-122
- C1 -
2OUK
1
?
C:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
8
PsiBlast_PDB
83.09
55%
-123
- C1 -
2OLK
1
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
10
PsiBlast_PDB
82.98
55%
-120
- C1 -
2Q0H
4
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
31
PsiBlast_CBE
82.85
55%
-119
- C1 -
2OLK
2
?
B:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
29
PsiBlast_CBE
82.68
55%
-122
- C1 -
2OLK
1
?
D:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
25
PsiBlast_CBE
82.55
55%
-125
- C1 -
2Q0H
4
?
B:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
23
PsiBlast_CBE
82.52
55%
-121
- C1 -
3C41
3
?
K:
[3-242]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
17
PsiBlast_PDB
82.38
36%
-141
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-269]
M
I
K
L
S
N
I
T
K
V
F
--
H
Q
G
TRTI
Q
A
--
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
---
T
------
T
L
S
E
S
E
L
T
K
A
-
R
-
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
---
P
K
D
E
V
-----
K
R
R
V
T
E
L
L
S
L
V
--
G
L
G
D
K
H
D
-
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
-
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--
28
PsiBlast_CBE
81.38
55%
-121
- C1 -
2OUK
2
?
B:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
33
PsiBlast_CBE
81.20
53%
-108
- C1 -
4U02
1
?
D:
[4-243]
I
I
R
I
R
N
L
H
K
W
F
--
G
P
L
----
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
------
A
L
R
E
-----
I
-
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
---
P
R
E
K
A
-----
E
K
K
A
L
E
L
L
E
R
V
--
G
I
L
D
Q
A
R
-
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
-
V
M
R
D
L
A
-
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
--
11
PsiBlast_PDB
80.96
55%
-120
- C1 -
3C4J
3
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
24
PsiBlast_CBE
80.64
55%
-123
- C1 -
3C4J
4
?
B:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
32
PsiBlast_CBE
78.69
55%
-117
- C1 -
2OLJ
3
?
B:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
6
PsiBlast_PDB
78.49
55%
-113
- C1 -
3C41
3
?
J:
[3-242]
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
----------
K
A
K
D
T
N
L
N
K
V
-
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
---
P
R
E
K
A
-----
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---
12
PsiBlast_PDB
77.96
53%
-111
- C1 -
4U00
3
?
A:
[4-243]
I
I
R
I
R
N
L
H
K
W
F
--
G
P
L
----
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
------
A
L
R
E
-----
I
-
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
---
P
R
E
K
A
-----
E
K
K
A
L
E
L
L
E
R
V
--
G
I
L
D
Q
A
R
-
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
-
V
M
R
D
L
A
-
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
--
128
HHSearch
76.41
55%
-109
- C1 -
4U00
3
?
A:
[4-240]
I
I
R
I
R
N
L
H
K
W
F
--
G
P
L
----
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
D
-----------
R
A
L
R
E
I
-
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
---
P
R
E
K
A
-----
E
K
K
A
L
E
L
L
E
R
V
--
G
I
L
D
Q
A
R
-
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
-
V
M
R
D
L
A
-
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
-----
14
PsiBlast_PDB
75.93
49%
-115
- C1 -
1B0U
4
HISP_SALTY
A:
[7-260]
-
L
H
V
I
D
L
H
K
R
Y
--
G
G
H
----
E
V
--
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQL
K
V
A
D
K
N
Q
L
R
L
L
R
-
T
-
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
---
S
K
H
D
A
-----
R
E
R
A
L
K
Y
L
A
K
V
--
G
I
D
E
R
A
Q
G
K
Y
-
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
-
I
M
Q
Q
L
A
-
E
-
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
58
PsiBlast_CBE
59.25
39%
-113
- C1 -
3TIF
7
Y796_METJA
A:
[1-221]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
----
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
---
T
N
------
D
L
D
D
D
E
L
T
K
I
-
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
-----
R
K
R
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
-------------------------------
90
PsiBlast_CBE
59.17
36%
-118
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-232]
-
L
H
I
G
H
L
S
K
S
F
--
Q
N
T
----
P
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
-
F
S
K
------
N
T
N
----
L
P
V
-
R
E
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
R
---
T
A
Q
E
------
R
Q
R
I
E
A
M
L
E
L
T
--
G
I
S
E
L
A
G
-
R
Y
-
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
--------------
91
PsiBlast_CBE
59.15
36%
-116
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-237]
-
L
H
I
G
H
L
S
K
S
F
--
Q
N
T
----
P
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
-
F
S
K
------
N
T
N
----
L
P
V
-
R
E
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
R
---
T
A
Q
E
------
R
Q
R
I
E
A
M
L
E
L
T
--
G
I
S
E
L
A
G
-
R
Y
-
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
--------------
57
PsiBlast_CBE
59.06
39%
-116
- C1 -
3TIF
7
Y796_METJA
B:
[1-221]
M
V
K
L
K
N
V
T
K
T
Y
KM
G
E
E
----
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
---
T
N
------
D
L
D
D
D
E
L
T
K
I
-
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
L
I
F
K
Y
R
GAM
S
G
E
E
R
-----
R
K
R
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
-------------------------------
119
HHSearch
58.66
32%
-122
- C1 -
4YER
4
?
A:
[5-256]
I
I
V
V
E
N
L
V
K
K
F
--
G
D
F
----
E
A
--
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
H
D
V
L
K
-------------
E
P
R
E
V
-
R
-
R
-
K
I
G
I
V
F
Q
D
Q
S
L
D
R
E
L
T
A
Y
E
N
M
Y
I
H
G
K
I
-
Y
G
Y
---
G
G
E
K
L
-----
K
K
R
I
L
E
L
L
E
F
V
--
E
L
L
E
F
K
D
-
K
P
-
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
-
Y
I
S
K
M
K
-
K
E
H
-
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
L
K
R
M
V
----------------
56
PsiBlast_CBE
58.56
39%
-110
- C1 -
1L2T
4
Y796_METJA
A:
[1-221]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
----
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
---
T
N
------
D
L
D
D
D
E
L
T
K
I
-
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
-----
R
K
R
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
-------------------------------
117
HHSearch
58.39
34%
-115
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-244]
-
L
H
I
G
H
L
S
K
S
F
--
Q
N
T
----
P
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
----------
N
T
N
L
P
V
R
-
E
-
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
-
K
G
---
R
T
A
Q
E
-----
R
Q
R
I
E
A
M
L
E
L
T
--
G
I
S
E
L
A
G
-
R
Y
-
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
-
D
M
I
A
A
L
R
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
-------
55
PsiBlast_CBE
57.77
39%
-115
- C1 -
1L2T
4
Y796_METJA
B:
[1-221]
M
I
K
L
K
N
V
T
K
T
Y
KM
G
E
E
----
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
---
T
N
------
D
L
D
D
D
E
L
T
K
I
-
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
L
I
F
K
Y
R
GAM
S
G
E
E
R
-----
R
K
R
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
-------------------------------
59
PsiBlast_CBE
57.58
32%
-117
- C1 -
1VCI
1
?
A:
[15-249]
---
L
E
N
L
T
K
R
F
--
G
N
F
----
T
A
--
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
---------
L
P
P
K
D
-------
R
-
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
-
A
F
P
L
--
K
K
F
---
P
K
D
E
I
-----
D
K
R
V
R
W
A
A
E
L
L
--
Q
I
E
E
L
L
N
-
R
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
-
E
I
K
K
L
Q
-
Q
-
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
-------
111
PsiBlast_CBE
55.34
32%
-146
- C1 -
4HLU
2
ECFA1_THEMA
D:
[21-226]
----------
Y
--
N
G
D
----
Y
V
--
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
-
L
A
A
A
G
E
I
F
L
D
G
---------------
S
P
A
D
P
F
L
L
-
R
-
K
-
N
V
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
S
L
E
I
M
G
L
---
D
E
S
E
M
-----
R
K
R
I
K
K
V
L
E
L
V
--
G
L
S
G
L
A
A
-
A
D
-
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
-
V
L
E
S
L
K
-
N
-
E
-
G
K
G
I
I
L
V
T
H
E
L
E
Y
L
D
D
M
-
D
F
I
L
H
I
S
N
G
T
I
D
F
C
G
S
W
E
E
F
--------------------
96
PsiBlast_CBE
37.50
31%
-117
- C1 -
5DGX
1
A:
[19-241]
-
V
T
I
K
D
L
S
F
A
F
--
G
E
H
----
K
V
--
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
E
G
E
I
L
L
D
--
G
V
D
----------
T
R
E
L
T
L
E
N
L
-
R
-
S
-
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
-
T
V
Y
N
N
I
A
F
G
-----
E
V
---
S
E
E
E
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
SD
G
I
N
T
N
I
G
-
N
N
-
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
-----------------
L
E
S
L
T
---
K
-
S
C
T
T
I
V
I
A
H
R
L
S
T
V
-
E
N
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
-------------------