@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03730: (2016-06-06 )
MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGKTTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVTTAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDLIVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFTVKENVAVV
Atome Classification :
(45 SA)
-.........10...--.-.--...20-.--........30........40........50........60.....-------------...70-.-..---....--.--.--80-.......-..90........100..-.------...--.110-....----...120....--...130--------.........140.......150.......160.......170.......180.......190.......-200..-.-....210.......220....----------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MSL
L
Q
F
QQV
G
Y
W
YK--N-K--SQP
L
--
F
--
Q
DI
N
I
S
F
QK
G
K
F
Y
T
I
V
GTSGTG
K
T
T
F
L
S
LAGGLDAPKEG
N
I
L
YDG-------------K
A
V
S
--K-IG---
L
T
N
F
--
R
--
N
--
Q
--
Y
V
S
I
V
F
Q
-
A
Y
N
L
L
P
Y
M
T
A
L
Q
N
V
T
T
A
-
M
------
E
IT--GSKE-KN
K
E
----
S
Y
A
L
D
M
L
Q
KV--GI
N
E
----------
K
Q
A
R
Q
K
V
L
TLSGGQ
Q
Q
R
V
S
I
T
R
A
FCCDT
D
L
I
V
ADEPTGNLDE
D
T
S
K
E
I
V
R
L
F
Q
D
L
AHKED
K
C
V
I
M
V
THD-EQI
A
K
-
V
-
S
D
I
N
I
R
L
SRG
S
F
T
V
KENVAVV----------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.01
34%
-97
- C1 -
1F3O
2
Y796_METJA
A:
[2-229]
----
I
K
L
K
N
V
T
K
T
Y
K
--
M
-
G
--
E
E
I
I
--
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
--
D
-
L
D
D
D
E
L
T
K
I
--
R
--
R
--
D
--
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
----
K
Y
R
--
G
A
M
S
G
E
E
R
R
----
K
R
A
L
E
C
L
K
M
A
--
E
L
E
E
----------
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
-------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.41
33%
-104
- C1 -
1L2T
4
Y796_METJA
B:
[1-229]
---
M
I
K
L
K
N
V
T
K
T
Y
K
--
M
-
G
--
E
E
I
I
--
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
--
D
-
L
D
DDE
L
T
K
I
--
R
--
R
--
D
--
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
IFKYRG
A
M
S
--
G
E
E
R
-
R
K
R
-------
A
L
E
C
L
K
M
A
--
E
L
E
E
----------
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
-------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.38
32%
-108
- C1 -
3TIF
7
Y796_METJA
B:
[1-229]
---
M
V
K
L
K
N
V
T
K
T
Y
K
--
M
-
G
--
E
E
I
I
--
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
--
D
-
L
D
DDE
L
T
K
I
--
R
--
R
--
D
--
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
IFKYRG
A
M
S
--
G
E
E
R
-
R
K
R
-------
A
L
E
C
L
K
M
A
--
E
L
E
E
----------
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
-------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
76.95
34%
-122
- C1 -
4U02
1
?
C:
[3-206]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
---------
P
L
HV
L
--
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
--
D
D
R
A
---
L
R
E
I
--
R
--
R
--
E
---
V
G
M
V
F
Q
-
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
------
R
V
R
--
R
W
P
R
-
E
K
A
E
----
K
K
A
L
E
L
L
E
R
V
--
G
I
L
D
-----------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
E
V
-
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.51
33%
-97
- C1 -
1L2T
4
Y796_METJA
A:
[1-229]
---
M
I
K
L
K
N
V
T
K
T
Y
K
--
M
-
G
--
E
E
I
I
--
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
--
D
-
L
D
D
D
E
L
T
K
I
--
R
--
R
--
D
--
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
IFKYR
G
A
M
S
--
G
E
E
R
-
R
K
R
-------
A
L
E
C
L
K
M
A
--
E
L
E
E
----------
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
-------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
75.03
34%
-115
- C1 -
4U02
1
?
B:
[3-206]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
---------
P
L
HV
L
--
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
--
D
D
R
A
---
L
R
E
I
--
R
--
R
--
E
---
V
G
M
V
F
Q
-
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
------
R
V
R
--
R
W
P
R
-
E
K
A
E
----
K
K
A
L
E
L
L
E
R
V
--
G
I
L
D
-----------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
E
V
-
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.69
34%
-113
- C1 -
4U02
1
?
D:
[3-206]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
---------
P
L
HV
L
--
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
--
D
D
R
A
---
L
R
E
I
--
R
--
R
--
E
---
V
G
M
V
F
Q
-
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
------
R
V
R
--
R
W
P
R
-
E
K
A
E
----
K
K
A
L
E
L
L
E
R
V
--
G
I
L
D
-----------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
E
V
-
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.87
34%
-117
- C1 -
4U00
3
?
A:
[3-206]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
---------
P
L
HV
L
--
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
--
D
D
R
A
---
L
R
E
I
--
R
--
R
--
E
---
V
G
M
V
F
Q
-
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
------
R
V
R
--
R
W
P
R
-
E
K
A
E
----
K
K
A
L
E
L
L
E
R
V
--
G
I
L
D
-----------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
E
V
-
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.85
32%
-101
- C1 -
3TIF
7
Y796_METJA
A:
[1-229]
---
M
V
K
L
K
N
V
T
K
T
Y
K
--
M
-
G
--
E
E
I
I
--
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
--
D
-
L
D
D
D
E
L
T
K
I
--
R
--
R
--
D
--
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
IFKYR
G
A
M
S
--
G
E
E
R
-
R
K
R
-------
A
L
E
C
L
K
M
A
--
E
L
E
E
----------
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
-------------------------------------------------------------------------------------------------------------------------------
82
Fugue
73.27
26%
-115
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
--
G
-
G
--
A
R
-
S
--
V
--
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
-------------
K
R
V
T
--
D
-
L
------
P
P
--
Q
--
K
--
R
--
N
V
G
L
V
F
Q
-
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
------
R
E
K
--
R
V
P
K
-
D
E
M
D
----
A
R
V
R
E
L
L
R
F
M
--
R
L
-
E
----------
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
-
Q
E
E
A
L
-
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
EKPGT
L
F
V
A
S
F
IGE
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R--
84
Fugue
72.89
24%
-135
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
QG
T
-
R
--
T
I
Q
A
--
L
--
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
--
T
-
L
S
---
E
S
E
L
--
T
--
K
AR
R
--
Q
I
G
M
I
F
Q
-
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
------
E
L
D
--
N
T
P
K
-
D
E
V
K
----
R
R
V
T
E
L
L
S
L
V
--
G
L
G
D
----------
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
-
I
-
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
FSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-------------
12
PsiBlast_PDB
72.46
34%
-109
- C1 -
4U02
1
?
A:
[3-206]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
---------
P
L
HV
L
--
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
--
D
D
R
A
---
L
R
E
I
--
R
--
R
--
E
---
V
G
M
V
F
Q
-
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
------
R
V
R
--
R
W
P
R
-
E
K
A
E
----
K
K
A
L
E
L
L
E
R
V
--
G
I
L
D
-----------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
E
V
-
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------
80
Fugue
71.41
25%
-121
- C1 -
1OXS
23
?
C:
[1-352]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
K
--
K
-
G
--
K
V
V
A
--
L
--
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
-------------
R
L
V
A
--
S
-
N
G
---
K
L
I
V
--
P
--
P
--
E
DR
K
I
G
M
V
F
Q
-
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
------
T
N
M
--
K
M
S
K
-
E
E
I
R
----
K
R
V
E
E
V
A
K
I
L
--
D
I
-
H
----------
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
-
P
A
D
I
F
-
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
YDNPVSIQVASLIGEINELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
9
PsiBlast_PDB
71.29
35%
-115
- C1 -
4YMV
1
?
J:
[8-200]
-------------
Y
K
--
N
F
G
--
S
L
E
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
NG
K
-
V
N
---
I
N
K
V
--
R
-----
Q
--
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
------
K
V
K
--
K
M
N
K
-
K
E
A
E
----
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
----------
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.07
35%
-112
- C1 -
4YMV
1
?
A:
[8-200]
-------------
Y
K
--
N
F
G
--
S
L
E
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
NG
K
-
V
N
---
I
N
K
V
--
R
-----
Q
--
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
------
K
V
K
--
K
M
N
K
-
K
E
A
E
----
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
----------
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
70.99
25%
-130
- C1 -
4MRS
1
ATM1_NOVAD
A:
[360-579]
---
S
V
T
F
D
N
V
V
F
G
Y
D
--
R
----
D
R
E
I
--
L
--
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
E
G
R
I
L
I
D
G
-------------
Q
D
I
A
--
H
-
V
T
---
Q
T
S
L
--
R
-----
A
--
A
L
G
I
V
P
Q
-
D
S
V
L
F
N
-
D
T
I
G
Y
N
I
A
Y
G
-
R
------
D
G
A
--
S
-------
R
----
A
E
V
D
A
A
A
K
G
A
--
A
I
A
D
F
I
A
R
LPQGYD
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
R
A
V
A
--
S
H
R
T
T
I
S
I
A
H
R
-
L
S
T
I
A
-
D
-
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
-------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.96
35%
-116
- C1 -
4YMU
2
?
A:
[8-200]
-------------
Y
K
--
N
F
G
--
S
L
E
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
NG
K
-
V
N
---
I
N
K
V
--
R
-----
Q
--
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
------
K
V
K
--
K
M
N
K
-
K
E
A
E
----
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
----------
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.86
35%
-115
- C1 -
4YMS
-
?
J:
[8-200]
-------------
Y
K
--
N
F
G
--
S
L
E
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
NG
K
-
V
N
---
I
N
K
V
--
R
-----
Q
--
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
------
K
V
K
--
K
M
N
K
-
K
E
A
E
----
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
----------
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
70.50
24%
-132
- C1 -
3TUI
1
METN_ECOLI
C:
[23-248]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
-
G
TR
T
I
Q
A
--
L
--
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
--
T
-
L
S
---
E
S
E
L
TK
A
--
R
--
R
--
Q
I
G
M
I
F
Q
-
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
------
E
L
D
--
N
T
P
K
-
D
E
V
K
----
R
R
V
T
E
L
L
S
L
V
--
G
L
G
D
-----------
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
V
V
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
-------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.93
35%
-114
- C1 -
4YMT
-
?
J:
[8-200]
-------------
Y
K
--
N
F
G
--
S
L
E
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
NG
K
-
V
N
---
I
N
K
V
--
R
-----
Q
--
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
------
K
V
K
--
K
M
N
K
-
K
E
A
E
----
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
----------
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
67.37
35%
-110
- C1 -
4YMU
2
?
J:
[8-200]
-------------
Y
K
--
N
F
G
--
S
L
E
V
--
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
N
NG
K
-
V
N
---
I
N
K
V
--
R
-----
Q
--
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
------
K
V
K
--
K
M
N
K
-
K
E
A
E
----
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
----------
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
64.49
32%
-139
- C1 -
4HLU
2
ECFA1_THEMA
D:
[26-216]
-------------------------
V
--
L
--
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
A
-
G
E
I
F
L
D
G
-------------
S
P
A
D
--
P
-
F
L
---
L
--------
R
--
K
--
N
V
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
S
-
L
------
E
I
M
--
G
L
D
E
-
S
E
M
R
----
K
R
I
K
K
V
L
E
L
V
--
G
L
S
G
----------
L
A
A
A
D
P
-
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
-
E
G
K
G
I
I
L
V
T
H
E
-
L
E
Y
L
D
-
D
-
M
D
F
I
L
H
I
S
N
G
T
--------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
64.18
33%
-113
- C1 -
3C41
3
?
K:
[15-219]
----------------------
S
L
E
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
KV
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.93
33%
-124
- C1 -
2OLJ
4
?
A:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
K
V
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
63.18
33%
-117
- C1 -
2OLK
1
?
D:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
KV
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
61.84
32%
-138
- C1 -
4HLU
3
ECFA1_THEMA
C:
[26-216]
-------------------------
V
--
L
--
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
A
-
G
E
I
F
L
D
G
-------------
S
P
A
D
--
P
-
F
L
---
L
--------
R
--
K
--
N
V
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
S
-
L
------
E
I
M
--
G
L
D
E
-
S
E
M
R
----
K
R
I
K
K
V
L
E
L
V
--
G
L
S
G
----------
L
A
A
A
D
P
-
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
-
E
G
K
G
I
I
L
V
T
H
E
-
L
E
Y
L
D
-
D
-
M
D
F
I
L
H
I
S
N
G
T
--------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.68
33%
-115
- C1 -
3C4J
3
?
A:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
K
V
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.39
33%
-119
- C1 -
2OLK
1
?
A:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
K
V
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
60.36
33%
-116
- C1 -
3C4J
4
?
B:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
KV
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
59.97
33%
-117
- C1 -
2OLK
2
?
B:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
KV
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
59.36
33%
-117
- C1 -
2Q0H
4
?
A:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
K
V
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
59.02
33%
-119
- C1 -
2OLK
1
?
C:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
KV
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
57.39
33%
-112
- C1 -
2OLJ
3
?
B:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
KV
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
57.16
37%
-112
- C1 -
1B0U
4
HISP_SALTY
A:
[45-229]
-----------------------------------------------------
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
QNI
N
L
V
R
D
KDGQL
K
V
A
D
--
K
-
N
Q
---
L
R
L
L
--
R
--
T
--
R
---
L
T
M
V
F
Q
-
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
------
Q
V
L
--
G
L
S
K
-
H
D
A
R
----
E
R
A
L
K
Y
L
A
K
V
--
G
I
D
E
----------
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
-
E
E
G
K
T
M
V
V
V
T
H
E
-
M
G
F
A
R
H
V
-
S
S
H
V
I
F
L
H
Q
G
---------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
56.54
33%
-119
- C1 -
2Q0H
4
?
B:
[39-240]
-------------------------
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
K
V
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.49
33%
-103
- C1 -
3C41
3
?
J:
[15-219]
----------------------
S
L
E
V
--
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
---
K
-
A
K
---
D
T
N
L
--
N
KV
R
--
E
--
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
------
K
V
R
--
K
W
P
R
-
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
----------
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
---------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
43.84
32%
-
- C1 -
3B5Y
2
MSBA_SALTY
A:
[342-535]
----
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
--
E
V
P
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
-------------
H
D
L
R
--
E
-
Y
T
---
L
A
S
L
--
R
--
N
--
Q
---
V
A
L
V
S
Q
-
N
V
H
L
F
N
D
T
V
A
-
N
N
I
A
Y
A
-
R
------
T
E
E
--
Y
S
R
E
-
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
DN
G
L
D
T
----------
I
I
G
E
N
G
V
L
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
43.82
32%
-
- C1 -
3B5Y
2
MSBA_SALTY
B:
[342-535]
----
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
--
E
V
P
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
-------------
H
D
L
R
--
E
-
Y
T
---
L
A
S
L
--
R
--
N
--
Q
---
V
A
L
V
S
Q
-
N
V
H
L
F
N
D
T
V
A
-
N
N
I
A
Y
A
-
R
------
T
E
E
--
Y
S
R
E
-
Q
I
E
E
AARM
A
Y
A
M
D
F
I
N
K
M
DN
G
L
D
T
----------
I
I
G
E
N
G
V
L
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
43.81
32%
-
- C1 -
3B5Y
2
MSBA_SALTY
C:
[342-535]
----
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
--
E
V
P
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
-------------
H
D
L
R
--
E
-
Y
T
---
L
A
S
L
--
R
--
N
--
Q
---
V
A
L
V
S
Q
-
N
V
H
L
F
N
D
T
V
A
-
N
N
I
A
Y
A
-
R
------
T
E
E
--
Y
S
R
E
-
Q
I
E
E
AARM
A
Y
A
M
D
F
I
N
K
M
DN
G
L
D
T
----------
I
I
G
E
N
G
V
L
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
43.81
32%
-
- C1 -
3B5Y
2
MSBA_SALTY
D:
[342-535]
----
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
--
E
V
P
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
-------------
H
D
L
R
--
E
-
Y
T
---
L
A
S
L
--
R
--
N
--
Q
---
V
A
L
V
S
Q
-
N
V
H
L
F
N
D
T
V
A
-
N
N
I
A
Y
A
-
R
------
T
E
E
--
Y
S
R
E
-
Q
I
E
E
AARM
A
Y
A
M
D
F
I
N
K
M
DN
G
L
D
T
----------
I
I
G
E
N
G
V
L
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
43.53
32%
-
- C1 -
3B5Z
2
MSBA_SALTY
A:
[342-535]
----
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
--
E
V
P
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
-------------
H
D
L
R
--
E
-
Y
T
---
L
A
S
L
--
R
--
N
--
Q
---
V
A
L
V
S
Q
-
N
V
H
L
F
N
D
T
V
A
-
N
N
I
A
Y
A
-
R
------
T
E
E
--
Y
S
R
E
-
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
DN
G
L
D
T
----------
I
I
G
E
N
G
V
L
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
43.53
32%
-
- C1 -
3B5Z
2
MSBA_SALTY
D:
[342-535]
----
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
--
E
V
P
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
-------------
H
D
L
R
--
E
-
Y
T
---
L
A
S
L
--
R
--
N
--
Q
---
V
A
L
V
S
Q
-
N
V
H
L
F
N
D
T
V
A
-
N
N
I
A
Y
A
-
R
------
T
E
E
--
Y
S
R
E
-
Q
I
E
E
AARM
A
Y
A
M
D
F
I
N
K
M
DN
G
L
D
T
----------
I
I
G
E
N
G
V
L
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
43.52
32%
-
- C1 -
3B5Z
2
MSBA_SALTY
B:
[342-535]
----
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
--
E
V
P
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
-------------
H
D
L
R
--
E
-
Y
T
---
L
A
S
L
--
R
--
N
--
Q
---
V
A
L
V
S
Q
-
N
V
H
L
F
N
D
T
V
A
-
N
N
I
A
Y
A
-
R
------
T
E
E
--
Y
S
R
E
-
Q
I
E
E
AARM
A
Y
A
M
D
F
I
N
K
M
DN
G
L
D
T
----------
I
I
G
E
N
G
V
L
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
43.50
32%
-
- C1 -
3B5Z
2
MSBA_SALTY
C:
[342-535]
----
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
--
E
V
P
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
-------------
H
D
L
R
--
E
-
Y
T
---
L
A
S
L
--
R
--
N
--
Q
---
V
A
L
V
S
Q
-
N
V
H
L
F
N
D
T
V
A
-
N
N
I
A
Y
A
-
R
------
T
E
E
--
Y
S
R
E
-
Q
I
E
E
AARM
A
Y
A
M
D
F
I
N
K
M
DN
G
L
D
T
----------
I
I
G
E
N
G
V
L
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
41.49
33%
-128
- C1 -
1VCI
1
?
A:
[31-209]
---------------------------------
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
-------------
R
D
V
T
--
Y
-
L
------
P
P
--
K
--
D
--
R
--
N
I
S
M
V
F
Q
-------
H
M
T
V
Y
E
N
I
A
F
P
-
L
--------
K
KF
P
K
D
E
-
I
D
K
R
V
---
R
W
A
A
E
L
L
Q
-----
I
E
E
----------
L
L
N
R
Y
P
A
-
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------