@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03840: (2016-06-06 )
MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDFNVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNFPVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGWAVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYGFSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGTLVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGLAIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLIPHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIALVGFLLSFTLKKPQRPAEQQPAR
Atome Classification :
(20 SA)
--------------------------------------.....-----------....10........20........30.......-.40.------.----.--------.--------------.----------------------...50........60........70.-...-.-...80....---....90......---------------.------------------.-----100--.-------....----....110......----.120.-----------......130--.--.-.....--140.---......150---........160--.--------------------------.--------------.-..-----------------..170-----------.........180......-.190...----...---.--------------------------------200-----........210-----..-----....------------------------.------------..220.......230.......240---------------------------------.......-..250-------------------------------------------........--------------------------.-260...--.----...---------.270----...-------....280-----..------......290....-.---..300-------.----..----------.....-.310.......320.......--330...------.....340---.......350---.--.------.--------.--....360--..--.......370...-..-...380.....-----------------..390-...-....-.400......-.410.-----......420......-----------..430.......440.......450.......-460.......470-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------MNTSI-----------EQKPFN
R
S
V
I
V
G
I
L
L
A
G
A
F
V
A
I
L
NQ
T
L
L
I
T
A
L
P
-
H
I
M
R
------
D
----F--------N--------------V----------------------DANQ
A
Q
W
L
T
T
S
F
M
LTN
G
I
L
I
P
I
T
A
F
L
-
I
E
K
-F-TS
R
A
L
L
I
T
A
---
M
S
I
F
TAG
T
V
V
GA---------------F------------------A-----P----N-------F
P
V
L
----
L
T
A
R
I
I
Q
AAGA
G
I
----
M
M
P
L
M
-----------
Q
T
V
F
L
T
I
F
P
--I--E-KRGQA--MG
M
V
---
G
L
V
I
SFAP----AIGPTLSG
W
A
V
--
E
--------------------------A--------------F-
S
W
-----------------
R
S
L
-------------
F
Y
I
I
L
P
F
A
V
I
D
L
I
L
A
S
I
L
-
M
K
N
V
T
T
L
----
R
K
T
---
Q
--------------------------------
I
D
------
I
L
S
V
I
L
S
T
F-------GF-----
G
G
L
L
------------------------
Y
------------
G
F
S
S
VGSYGWS
S
S
T
V
L
I
S
L
L
V
G
V
-----------------------------------
I
A
L
L
L
F
I
-
T
R
Q
---------------------------------------------
M
K
LKK
P
M
L
--------------------------
E
-
F
-
R
V
F
T
--
F
----
G
V
F
---------
S
L
T
T
----
L
L
G
-------
T
L
V
F
A
-
L
-----
L
I------GTE
T
I
L
P
L
Y
TQNV-R---D
V
T
---------A----FD----------TG
L
M
L-L
P
G
A
V
V
M
G
F
M
S
P
I
I
G
R
I
F
D
R
V--GG-RG
L
------
A
I
A
G
F
C
I
I
---
F
LTSLP
F
M
Q----L--T------D--------H--T
S
L
A
W
----
I
V
--
V
L
Y
T
V
R
L
L
G
-
T
A
M
-
I
M
-
M
PVT
T
A
G
I
N
A
L
-----------------
P
R
H
L--IPH-GTA
M
-
N
N
T
I
R
Q
V
G
G
S
-
I
G
T
A
L
-----
L
V
S
V
M
SNQ-AAHAGT-----------TN
V
K
H
A
A
L
HGM
N
A
A
F
I
V
A
A
V
I
A
L
V
G
F
L
L
S
F
T
L-KKPQRPAEQQPAR-----------
42
Fugue
70.83
18%
-147
- C2 -
4OK4
1
?
A:
[30-733]
HPNLIVT
E
Q
D
V
A
N
I
A
A
SWESY
D
A
Y
A
E
Q
L
N
A
D
K
T
N
L
D
A
F
M
A
E
G
V
V
V
P
MPKDAGGG
Y
T
H
E
Q
H
K
R
N
Y
K
A
I
R
N
A
G
F
L
Y
Q
V
T
G
D
E
K
Y
L
T
F
A
K
-
D
L
L
L
------
A
----
Y
--------
A
--------------
K
M
YPSLGEHPNRKEQSPGRLFWQ
S
L
N
E
A
V
W
L
V
Y
S
I
Q
G
Y
D
A
I
I
D
G
L
A
A
E
E
-
K
Q
E
-
I
-
E
S
G
V
F
L
P
M
A
---
K
F
L
S
V
E
S
---
P
E
---------------
T
------------------
F
-----
N
----
K
-------
I
H
N
L
----
G
T
W
A
V
A
A
V
G
M
T
G
Y
----
V
L
G
N
D
-----------
E
L
V
E
I
S
L
M
G
--
L
--
D
-
K
T
G
K
A
--
G
F
M
K
---
Q
L
D
K
L
F
S
P
DGYY
T
E
G
P
Y
Y
Q
R
Y
A
L
--
M
--------------------------
P
--------------
F
-
I
W
F
A
K
A
I
E
T
N
EPERKIFEY
R
N
N
-------------
I
L
L
K
A
V
Y
T
T
I
D
L
S
Y
A
G
Y
F
-
F
P
I
N
D
A
L
----
K
D
K
---
G
--------------------------------
I
D
T
V
E
L
V
H
A
L
A
I
V
Y
S
I
T
-------
G
D
-----
N
T
L
L
------------------------
D
------------
I
A
Q
E
Q
G
R
I
S
L
T
G
D
G
L
K
V
A
K
A
V
G
E
GL
T
Q
P
Y
N
Y
R
S
I
L
L
G
D
G
ADGDQ
G
A
L
S
I
H
R
L
G
E
G
HN
H
M
A
L
V
A
K
N
-
T
S
Q
GMGHGHFDKL
N
W
L
L
Y
D
NGNEIVTDYGAARYLNVEAKYGGHYLAEN
N
T
W
A
K
Q
T
I
AHN
T
L
V
V
NEQSHFYGD
V
T
T
A
D
L
H
H
P
E
V
-
L
-
S
F
Y
S
--
G
----
E
D
Y
---------
Q
L
S
S
----
A
K
E
ANAYDG
V
E
F
V
R
S
-
M
-----
L
L
V
N
V
PSL
E
H
P
I
V
V
D
V
L
N
V
S
A
-
D
---
K
A
S
---------
T
----
F
D
----------
L
P
L
Y
F
-
N
G
Q
I
I
D
F
S
F
K
V
K
D
N
K
N
V
M
K
M
L
--
G
K
-
R
N
----------
G
Y
Q
H
L
---
W
L
R
N
T
A
P
V
G
-------
D
------
A
--------
S
--
E
R
A
T
W
----
I
L
DD
R
F
Y
S
Y
A
F
V
T
S
T
P
S
-
K
K
-
Q
N
V
L
I
A
E
L
G
A
N
D----------------
P
N
Y
N
--
L
R
Q
-
Q
Q
V
L
----
I
R
R
V
E
K
--
A
K
Q
A
S
-----
F
V
S
V
L
E
P
H
-
G
K
Y
D
G
S
LETTSGAYSNV
K
S
V
K
H
V
S
E
N
G
K
D
V
V
V
V
D
L
K
D
G
S
N
V
V
V
A
L
S
Y
N
A
N
S
E
Q
V
H
K
V
N
A
G
E
E
A
I
E
W
K
G
F
S
S
V
V
V
43
Fugue
67.12
21%
-175
* C6 *
4BWZ
2
?
A:
[3-386]
-----------------------G
A
E
H
L
L
E
I
F
Y
L
L
L
A
A
Q
V
C
A
F
-----------
I
F
K
R
L
N
Q
P
V
V
I
G
E
V
L
A
G
V
L
V
G
--------
P
A
L
L
-
G
L
V
H
------
E
----
G
--------
E
--------------
I
----------------------
L
E
F
L
A
E
L
G
A
V
F
L
L
F
M
V
G
L
E
T
R
L
K
D
I
L
A
V
G
K
-
E
-
A
F
L
V
A
V
L
G
V
---
A
L
P
F
L
G
G
Y
L
Y
G
L
---------------
E
------------------
I
GF---
E
----
T
-------
L
P
A
L
----
F
L
G
T
A
L
V
A
T
S
V
G
I
----
T
A
R
V
L
-----------
Q
E
---------------------
L
G
V
L
---
S
---------------------------------------------------------------------------------------
R
P
Y
-------------
S
R
I
I
L
G
A
A
V
I
D
D
V
L
G
L
I
V
-
L
A
C
V
N
G
V
----
A
E
T
-----------------------------------------------------------------------------------------------------------------
G
Q
V
E
V
G
A
I
T
R
L
I
V
L
S
V
V
F
-----------------------------------
V
G
L
A
V
F
L
-
S
T
L
---------------------------------------------
I
A
-
R
L
P
L
E
--------------------------
R
-
L
-
P
V
G
S
-------------------------------------
P
L
G
F
A
-
L
-----
A
L
------
G
V
G
M
A
A
L
A
A
S
I
G
L
-
A
---
P
I
V
---------
G
----
A
F
----------
L
G
G
M
L
-
L
S
E
V
-----------
R
E
K
Y
R
L
--
E
E
-
P
I
F
------
A
I
E
S
F
L
A
P
---
I
F
F
A
M
V
G
V
R
----
L
---------
E
--------
L
--
S
A
L
A
S
----
P
V
--
V
L
V
A
G
T
V
V
T
-
V
I
A
-
I
L
-
G
K
V
L
G
G
F
L
G
A
L
-----------------
T
Q
G
----------------
V
R
S
A
L
T
-
V
G
C
G
M
APRG
E
V
G
L
I
V
A
A
L
-
G
L
K
A
G
A
-----------
V
N
E
E
E
Y
A
I
V
L
F
M
V
V
F
T
T
L
F
A
P
F
A
L
K
P
L
I
A
W
T
E
-
R
E
R
A
A
K
E
-----------------
22
HHSearch
65.94
13%
-172
- C7 -
4ZP0
3
MDFA_ECOLI
A:
[14-365]
-------------------------------------------------------------------
L
V
L
Y
E
F
S
T
Y
I
G
N
D
M
I
Q
P
G
M
L
-
A
V
V
E
------
Q
----
Y
--------
Q
--------------
A
----------------------
G
I
D
W
V
P
T
S
M
T
A
Y
L
A
G
G
M
F
L
Q
W
L
L
G
P
L
-
S
D
R
-
I
-
G
R
R
P
V
M
L
A
G
---
V
V
W
F
I
V
T
C
L
A
I
L
---------------
L
------------------
A
-----
Q
----
N
-------
I
E
Q
F
----
T
L
L
R
F
L
Q
G
I
S
L
C
F
----
I
G
A
V
G
-----------
Y
A
A
I
R
E
S
F
E
--
E
--
A
-
V
C
I
K
I
--
T
A
L
M
---
A
N
V
A
L
I
A
P
----
L
L
G
P
L
V
G
A
A
W
I
--
H
--------------------------
V
--------------
L
-
P
W
-----------------
E
G
M
-------------
F
V
L
F
A
A
L
A
A
I
S
F
F
G
L
Q
R
A
-
M
P
E
T
A
T
R
----
I
G
E
---
K
--------------------------------
L
S
-------------------------------------------------------------------------------
L
---------------------------------------------------------
K
E
---------------------------------------------
L
--
G
R
D
----------------------------
Y
-
K
-
L
V
L
K
--
N
----
G
R
F
---------
V
A
G
A
----
L
A
L
-------
G
F
V
S
L
-
P
-----
L
L
------
A
W
I
A
Q
S
P
I
I
I
I
T
G
-
E
---
Q
L
S
---------
S
----
Y
E
----------
Y
G
L
L
Q
-
V
P
I
F
G
A
L
I
A
G
N
L
L
L
A
R
L
T
S
R
R
--
T
V
-
R
S
L
------
I
I
M
G
G
W
P
I
---
M
I
G
L
L
V
A
A
A
----
A
T
V
I
------
S
--------
S
--
H
A
Y
L
W
----
M
T
--
A
G
L
S
I
Y
A
F
G
-
I
G
L
-
A
N
-
A
G
L
V
R
-
L
T
L
F
A
-----------------
S
D
M
S
--
K
G
T
-
V
S
A
A
-
M
G
M
L
Q
M
L
I
F
T
-
V
G
I
E
I
-----
S
K
H
A
W
L
-----------------------------------------------------------------------------
40
Fugue
64.30
18%
-180
- C6 -
2OCC
-
COX1_BOVIN
A:
[1-514]
--------------------------------------
M
F
I
N
R
-----------
W
L
F
S
T
N
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
-
A
E
L
G
------
Q
----
P
--------
G
TLLG--------------------------------------------
D
D
Q
I
Y
N
V
V
V
T
A
H
A
F
V
-
M
I
F
-
F
-
M
V
M
P
I
M
I
G
G
---
F
G
N
W
L
V
P
L
M
I
G
A
PDMAF
P
R
M
N
N
M
S
F
W
L
L
------------------
P
-----
P
----
S
-------
F
L
L
L
----
L
A
S
S
M
V
E
-
A
G
A
G
T
----
G
W
T
V
Y
PPLAGNLAHAG
A
S
V
D
L
T
I
F
S
--
L
--
H
-
L
A
G
V
S
S
I
L
G
A
I
---
N
F
I
T
T
I
I
N
----
M
K
P
P
A
M
S
Q
Y
Q
T
--
P
--------------------------
L
--------------
F
-
V
W
-----------------
S
V
M
-------------
I
T
A
V
L
L
L
L
S
L
P
V
L
A
A
G
I
T
-
M
L
L
T
D
R
N
----
L
N
T
---
T
FFDPAGGGD
P
I
L
Y
Q
H
L
F
W
F
F
G
H
P
E
V
Y
I
L
I
L
P
G
F
G
------
M
I
S
H
I
V
T
Y
Y
S
GKKEPF
G
Y
-----
M
G
M
V
------------------------
W
------------
A
M
M
S
I
G
F
L
G
F
I
V
W
A
H
H
M
F
T
V
G
M
D
-----------------------------------
V
D
T
R
A
Y
F
-
T
S
A
---------------------------------------------
T
M
I
I
A
I
P
T
--------------------------
G
-
V
-
K
V
F
S
--
W
----
L
A
T
L
HGGNIKWS
P
A
M
M
----
W
A
L
-------
G
F
I
F
L
-
F
-----
T
V
------
G
G
L
T
G
I
V
L
A
N
-
S
S
-
L
---
D
I
V
---------
L
----
H
D
----------
T
Y
Y
V
V
-
A
H
F
H
Y
V
L
S
M
---------------
G
-
A
V
F
------
A
I
M
G
G
F
V
H
---
W
F
P
L
F
S
G
Y
T
----
L
----------------------
N
D
T
W
----
A
K
--
I
H
F
A
I
M
F
V
G
-
V
N
M
-
T
F
-
F
P
Q
H
F
L
G
L
S
G
M
-----------------
P
R
R
Y
SD
Y
P
D
-
A
Y
T
M
-
W
N
T
I
S
S
M
G
S
F
-
I
S
L
T
A
-----
V
M
L
M
V
F
I
I
-
W
E
A
F
A
S
--------------
K
R
E
V
L
---
T
V
D
L
T
T
T
N
L
E
W
L
N
G
C
P
P
P
Y
H
T
-
F
E
E
P
T
Y
V
N
L
K
--------------
25
HHSearch
63.81
13%
-175
- C7 -
4W6V
-
?
A:
[23-490]
-------------------------------------------------------------------
L
F
L
S
E
M
W
E
R
F
S
F
Y
G
I
R
P
L
L
I
-
L
F
M
A
ATVFDG
G
----
M
--------
G
--------------
L
----------------------
P
R
E
Q
A
S
A
I
V
G
I
F
A
G
S
M
Y
L
A
A
L
P
G
G
L
L
-
A
D
N
-
W
L
G
Q
Q
R
A
V
W
Y
G
---
S
I
L
I
A
L
G
H
L
S
I
A
---------------
L
------------------
S
-----
A
FF--
G
-------
N
D
L
F
----
F
I
G
L
V
F
I
V
L
G
T
G
L
----
F
K
T
C
I
-----------
S
V
M
V
G
T
L
Y
K
--
P
GD
A
-
R
R
D
G
G
--
F
S
L
F
---
Y
M
G
I
N
M
G
S
----
F
I
A
P
L
L
S
G
W
L
L
--
R
--------------------------
T
--------------
H
-
G
W
-----------------
H
W
G
-------------
F
G
I
G
G
I
G
M
L
V
A
L
L
I
F
R
G
F
A
I
P
A
M
K
R
Y
----
D
A
E
---
V
--------------------------------
G
L
------
D
S
S
W
N
K
P
T
------------------
G
------------------------
R
W
V
T
A
I
M
A
V
V
V
V
I
I
A
L
I
S
Q
G
V
I
P
I
N
P
V
M
I
A
S
L
L
V
Y
V
-----------------------------------
I
A
A
S
V
T
L
Y
F
I
Y
---------------------------------------------
L
F
A
F
A
K
M
S
--------------------------
R
-
K
-
D
R
A
R
--
L
----
L
V
C
---------
F
I
L
L
----
V
S
A
-------
A
F
F
W
S
-
A
-----
F
E
------
Q
K
P
T
S
F
N
L
F
A
N
D
Y
-
T
---
D
R
M
VMGF-----
E
----
I
P
----------
T
V
W
F
Q
-
S
I
N
A
L
F
I
I
L
L
A
P
V
F
S
W
A
------------PS
S
I
T
K
F
V
I
G
I
L
C
A
---
A
A
G
F
A
V
M
M
Y
----
A
--
A
------
Q
H
V
L
S
S
G
GA
G
--
V
S
P
L
W
----
L
V
--
M
S
I
L
L
L
T
L
G
-
E
L
C
-
L
S
-
P
I
G
L
A
T
M
T
L
L
A
-----------------
P
D
R
M
--
R
G
Q
-
V
M
G
L
-
W
F
C
A
S
S
L
G
N
L
-
A
A
G
L
I
-----
G
G
H
V
K
A
D
Q
-------------------------
L
D
M
L
P
T
L
F
A
R
C
S
I
A
L
V
I
C
A
A
V
-----------------------------
37
Fugue
62.32
12%
-171
- C7 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
----------------------------FKPAPHKARL
P
A
A
E
I
-----------
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
-
P
Y
L
V
------
E
----
Q
--------
G
--------------
F
----------------------
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
-
S
D
R
-
S
-
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
P
W
-----------
A
------------------
T
-----
S
----
S
-------
I
A
V
M
----
F
V
L
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
-----------
G
R
T
M
V
H
W
W
S
--
Q
--
K
-
E
R
G
G
I
--
V
S
V
W
---
N
C
A
H
N
V
G
G
----
G
I
P
P
L
L
F
L
L
G
M
--
A
--------------------------
W
--------------
F
N
D
W
-----------------
H
A
A
-------------
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
-
M
R
D
T
P
Q
S
------------------------------------------------------------------------------------------------------
C
------------
G
L
P
P
I
E
E
Y
K
N
D
T
---------------------------------------------------------------------------------------------------------
A
K
Q
I
F
--------------------------
M
-
Q
-
Y
V
L
P
--
N
----
K
L
L
---------
W
Y
I
A
----
I
A
N
-------
V
F
V
Y
L
-
L
-----
R
Y
------
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
---------
L
----
D
K
----------
S
S
W
A
Y
-
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
FR
G
N
-
R
G
A
------
T
G
V
F
F
M
T
L
---
V
T
I
A
T
I
V
Y
W
----
M
--
N
------
P
--------
A
--
G
N
P
T
V
----
D
M
--
I
C
M
I
V
I
G
F
L
-
I
Y
G
-
P
V
-
M
L
I
G
L
H
A
L
E
L
A
-----------------
P
K
K
A
--
A
G
T
-
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
-----
I
V
G
Y
T
V
D
--------------------
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
-
R
H
E
Q
L
L
Q
E
L
V
P
-------------
27
HHSearch
61.15
13%
-152
- C7 -
4GC0
4
XYLE_ECOLI
A:
[8-429]
----------------------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
-
S
L
N
T
------
V
----
F
VAPQNLS
E
S
--------------
A
----------------------
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
-
S
N
R
-
F
-
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
---------------
W
PELGFTSINPDNTVPVYL
A
-----
G
----
Y
-------
V
P
E
F
----
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
-----------
P
M
Y
I
A
E
L
A
P
--
A
--
H
-
I
R
G
K
L
--
V
S
F
N
---
Q
F
A
I
I
F
G
Q
----
L
L
V
Y
C
V
N
Y
F
I
A
--
R
S
GD
A
S
W
L
N
------------------
T
--------------
D
-
G
W
-----------------
R
Y
M
-------------
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
-
Y
T
-
V
P
E
S
P
R
W
----
L
M
S
---
R
--------------------------------
G
K
------
Q
E
Q
A
E
G
I
L
----------------
R
K
I
------------------------
M
------------
G
N
T
-
L
A
T
Q
A
V
----------------------------------------------------
Q
E
I
-
K
H
S
---------------------------------------------
L
D
H
-
G
R
K
T
--------------------------
G
-
G
-
R
L
L
M
F
G
V
----
G
V
I
---------
V
I
G
V
----
M
L
S
I
------
F
Q
Q
F
V
-
G
-----
I
N
------
V
V
L
Y
Y
A
P
E
V
F
K
-
T
-
L
---
G
A
S
---------
T
----
D
I
----------
A
L
L
Q
T
-
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
--
G
R
-
K
P
L
------
Q
I
I
G
A
L
G
M
---
A
I
G
M
F
S
L
G
T
----
A
--
F
------
Y
T
-------
Q
--
A
P
G
I
V
----
A
L
--
L
S
M
L
F
Y
V
A
A
-
F
A
M
S
W
G
-
P
V
C
W
V
L
L
S
E
I
F
-----------------
P
N
A
I
--
R
G
K
-
A
L
A
I
-
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
-----
F
P
M
M
-------------------------------------------------------------------------------
46
Fugue
59.55
16%
-147
- C7 -
3WDO
-
?
A:
[3-455]
-----------------------------------------
D
Y
-----------
K
M
T
P
G
E
R
R
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
-
Y
G
M
A
------
L
----
Q
--------
G
--------------
A
----------------------
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
-
S
D
R
-
I
-
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
---------------
L
------------------
S
-----
D
----
S
-------
I
W
G
I
----
I
L
G
R
A
L
Q
G
S
G
A
------
I
A
A
A
V
-----------
M
A
L
L
S
D
L
T
R
--
E
--
Q
-
N
R
T
K
A
--
M
A
F
I
---
G
V
S
F
G
I
T
F
----
A
I
A
M
V
L
G
P
I
I
T
--
H
--------------------------
K
--------------
L
-
G
L
-----------------
H
A
L
-------------
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
-
V
P
N
S
S
T
H
----
V
L
N
---
R
--------------------------------
E
S
-----------------------------
G
M
V
K
------------------------
G
------------
S
F
S
K
V
L
A
-----
E
P
R
L
L
K
L
N
F
G
I
-----------------------------------
M
C
L
H
M
L
L
-
M
S
T
---------------------------------------------
F
V
A
L
P
G
Q
L
--------------------------
A
-
D
-
A
G
F
P
--
A
----
A
E
H
---------
W
K
V
Y
----
L
A
T
-------
M
L
I
A
F
-
G
-----
S
V
------
V
P
F
I
I
Y
A
E
V
K
R
K
M
-
K
---
Q
V
F
---------
V
----
F
C
----------
V
G
L
I
V
-
V
A
E
I
V
L
W
N
A
Q
T
----
Q
F
W
Q
L
V
--
V
G
-
V
Q
L
------
F
F
V
A
F
N
L
M
E
A
-
L
L
P
S
L
I
S
K
E
----
S
--
P
------
A
--------
G
--
Y
K
G
T
A
----
M
G
--
V
Y
S
T
S
Q
F
L
G
-
V
A
I
-
G
G
-
S
L
G
G
W
I
D
G
M
F
D
-----------------
G
Q
G
V
--
F
L
A
-
G
A
M
L
-
A
A
V
W
L
A
V
A
S
T
-
M
K
E
P
P
-----
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
-----------
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
-
K
V
T
N
R
F
E
V
E
Q
A
I
R
QAL--------
23
HHSearch
58.90
17%
-163
- C7 -
3O7Q
1
FUCP_ECOLI
A:
[34-406]
----------------------------------------------------------------------
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
-
Q
F
Q
Q
------
A
----
F
--------
T
--------------
L
----------------------
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
-
M
K
K
-
L
-
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
---------------
P
------------------
A
A
E
I
--
M
----
N
-------
Y
T
L
F
----
L
V
G
L
F
I
I
A
A
G
L
G
C
----
L
E
T
A
A
-----------
N
P
F
V
T
V
L
G
P
--
E
--
S
-
S
G
H
F
R
--
L
N
L
A
---
Q
T
F
N
S
F
G
A
----
I
I
A
V
V
F
G
Q
S
L
I
--
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
--------------
L
-
S
V
-----------------
Q
T
P
-------------
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
-
L
-
T
K
F
-
P
A
L
----
Q
S
D
---
N
--------------------------------
H
S
------
D
A
K
---------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------
G
S
F
S
A
--
S
--------------------------
L
-
S
-
R
L
A
R
--
I
----
R
H
W
---------
R
W
A
V
----
L
A
Q
-------
F
C
Y
V
G
-
A
-----
Q
T
------
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
M
T
---------
A
----
G
F
----------
A
A
N
Y
L
-
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
--
A
P
-
H
K
V
------
L
A
A
Y
A
L
I
A
---
M
A
L
C
L
I
S
A
F
----
A
---------
G
-----------
G
-
H
V
G
----
L
---
I
A
L
T
L
C
S
A
F
-
M
S
I
-
Q
Y
-
P
T
I
F
S
L
G
I
K
N
L
-----------------
G
Q
D
T
--
K
-
Y
-
G
S
S
F
-
I
-
V
M
T
I
I
G
G
G
-
I
V
T
P
V
-----
M
G
F
V
S
D
-----------------------------------------------------------------------------
38
Fugue
58.72
16%
-154
- C7 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
---------------------------------------------------------------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
-
D
M
A
R
------
D
----
L
--------
N
--------------
V
----------------------
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
-
S
D
R
-
V
-
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
---------------
T
------------------
T
-----
S
----
S
-------
L
T
V
L
----
I
A
A
S
A
M
Q
G
M
G
T
G
V
----
G
G
V
M
A
-----------
R
T
L
P
R
D
L
Y
E
--
R
--
T
-
Q
L
R
H
A
--
N
S
L
L
---
N
M
G
I
L
V
S
P
----
L
L
A
P
L
I
G
G
L
L
D
--
T
--------------------------
M
--------------
W
-
N
W
-----------------
R
A
C
-------------
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
-
M
P
E
T
R
P
V
----
D
A
P
---
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
L
---------------------------------------------
L
T
S
Y
K
T
L
F
--------------------------
G
-
N
-
S
G
F
N
--
C
----
Y
L
L
---------
M
L
I
G
----
G
L
A
-------
G
I
A
A
F
-
E
-----
A
C
------
S
G
V
L
M
G
A
V
L
G
L
S
S
-
M
---
T
V
S
---------
I
----
L
F
----------
I
------
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
--
S
T
-
L
M
W
------
Q
S
V
I
C
C
L
L
---
A
G
L
L
M
W
I
P
D
----
W
--
F
------
G
--------
V
--
M
N
V
W
T
----
L
L
--
V
P
A
A
L
F
F
F
G
-
A
G
M
-
L
F
------------------------------------
P
L
-
A
T
S
G
-
A
M
E
P
F
P
F
L
A
G
-
T
A
G
A
L
-----
V
G
G
L
Q
N
I
G
-
S
G
V
L
A
S
------------
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
-------------------------
15
HHSearch
57.52
12%
-172
- C7 -
1PW4
-
GLPT_ECOLI
A:
[25-430]
----------------------------------------------------------
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
-
Y
L
V
-------
E
----
Q
--------
G
--------------
F
----------------------
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
-
S
D
R
-
S
-
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
---------------
F
------------------
V
-----
P
W
A
T
S
S
-------
I
A
V
M
----
F
V
L
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
-----------
G
R
T
M
V
H
W
W
S
--
Q
--
K
-
E
R
G
G
I
--
V
S
V
W
---
N
C
A
H
N
V
G
G
----
G
I
P
P
L
L
F
L
L
G
M
--
A
W-------------------------
F
--------------
N
-
D
W
-----------------
H
A
A
-------------
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
-
M
R
D
T
P
Q
S
----
C
G
L
---
P
--------------------------------
P
I
------
E
E
Y
K
N
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
A
K
Q
I
F
--------------------------
M
-
Q
-
Y
V
L
P
--
N
----
K
L
L
---------
W
Y
I
A
----
I
A
N
-------
V
F
V
Y
L
-
L
-----
R
Y
------
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
---------
L
----
D
K
----------
S
S
W
A
Y
-
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
--
F
R
-
G
N
R
------
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
-------
N
------
P
--------
A
--
G
N
P
T
V
----
D
M
--
I
C
M
I
V
I
G
F
L
-
I
Y
G
-
P
V
-
M
L
I
G
L
H
A
L
E
L
A
-----------------
P
K
K
A
--
A
G
T
-
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
-----
V
G
Y
T
V
D
F
---------------------------
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
-----------------------------
39
Fugue
57.36
12%
-171
- C7 -
1PV6
-
LACY_ECOLI
A:
[1-417]
--------------------------------------------------------
M
Y
Y
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
-
I
W
L
H
------
D
----
I
N-------
H
--------------
I
----------------------
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
-
S
D
K
-
L
-
G
L
R
K
Y
L
L
W
I
---
I
T
G
M
L
V
M
F
A
P
F
F
---------------
I
------------------
F
-----
I
----
F
-------
G
P
L
L
Q
YNI
L
V
G
S
I
V
G
G
I
Y
L
G
F
----
C
F
N
A
G
-----------
A
P
A
V
E
A
F
I
E
K
V
S
--
R
-
R
S
N
F
E
--
F
G
R
A
---
R
M
F
G
C
V
G
W
----
A
L
G
A
S
I
V
G
I
M
F
--
T
--------------------------
I
----------------
N
N
-----------------
Q
F
V
-------------
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
-
K
T
D
A
P
S
S
----
A
T
V
---
A
--------------------------------------------------------------------------------------------------------------------
N
A
V
G
A
N
H
S
A
F
S
-----------------------------------
L
K
L
A
L
E
L
-
F
R
Q
---------------------------------------------
P
K
L
W
F
L
S
L
--------------------------
Y
-
V
-
I
G
V
S
--
C
----
T
Y
D
---------
V
F
D
Q
----
Q
F
A
-------
N
F
F
------------------------
T
S
F
F
A
T
-
G
---
E
Q
G
---------
T
----
R
V
----------
F
G
Y
V
T
-
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
--
G
G
-
K
N
A
------
L
L
L
A
G
T
I
M
---
S
V
R
I
I
G
S
S
F
----
A
--
T
------
S
--------
A
--
L
E
V
V
I
----
L
K
--
T
L
H
M
F
E
V
P
F
-
L
L
V
-
G
C
-
F
K
Y
I
T
S
Q
F
E
--------------------------------------
V
R
F
S
A
T
-
I
Y
L
V
C
-----
F
C
F
F
K
Q
L
A
-
M
I
F
M
S
V
-----------
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
-
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A------
45
Fugue
57.13
19%
-94
- C1 -
2X2Z
2
AMA1_TOXGO
A:
[6-416]
-------------------------------------------------------
G
N
P
F
Q
A
N
---------------------
V
E
M
K
-
T
F
M
E
------
R
----
F
--------
N
--------------
L
----------------------
T
H
H
H
Q
S
G
I
Y
V
D
L
G
Q
D
K
E
V
--------------------------------
D
G
T
L
Y
R
E
---------------
P
------------------
A
-----
G
----
L
-------
C
P
I
W
----
G
K
H
I
E
L
Q
Q
P
D
R
--------
P
P
Y
-----------
R
N
N
F
L
E
D
V
P
--
T
--
E
-
K
E
Y
K
Q
--
S
G
N
P
LPG
G
F
N
L
N
F
V
T
----
P
S
G
Q
R
I
S
P
F
P
M
--
E
--------------------------
L
--------------
L
-
E
N
-----------------
S
N
I
-------------
K
------
A
S
T
D
L
G
R
C
A
E
F
-
A
F
K
T
V
A
M
D
KNN
K
A
T
---
K
--------------------------------
Y
R
------
Y
P
F
V
Y
D
S
K
K
-------
R
L
-----
C
H
I
L
YVSMQ
L
M
E
G
KKYCSVKGEPPDLT
W
Y
------------
C
F
K
P
R
K
S
V
T
E
N
H
H
L
I
Y
G
S
A
Y
V
G
E
-----------------------------------
N
P
-------
D
A
---------------------------------------------
F
I
S
K
C
P
N
Q
--------------------------
A
-
L
-
R
G
Y
R
--
F
----
G
V
W
K
KG
R
C
L
---
D
Y
T
E
----
L
T
D
-------
T
V
I
E
R
-
V
-----
E
S
------
K
A
Q
C
W
V
K
T
F
E
----
N
---
D
G
V
---------
A
----
S
D
----------
Q
P
H
T
Y
P
L
T
S
Q
A
S
W
N
D
W
W
P
L
H
Q
S
D
Q
P
H
S
--
G
G
-
V
G
R
------
N
-
Y
G
F
Y
Y
V
---
D
T
T
G
E
G
K
C
A
----
L
--
S
------
D
--------
Q
--
V
P
D
-------
C
--
L
V
S
D
S
A
A
V
S
-
Y
T
A
-
A
G
-
S
L
S
E
E
T
P
N
F
I
I
-----------------
P
S
N
T
--
P
P
T
P
E
T
A
L
-
Q
C
T
A
D
K
F
P
D
S
-
F
G
A
C
-----------
D
V
Q
-
A
C
K
R
Q
K
-----------
T
S
C
V
G
-------------------
G
Q
I
Q
S
T
S
V
-
D
---
C
T
A
D
E
Q
N
E
C
-----------
19
HHSearch
56.06
11%
-152
- C7 -
4ZW9
4
GTR3_HUMAN
A:
[35-447]
---------------------------------------------------------------
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
-
I
I
K
E
------
F
----
I
--------
T
K
T
L
T
D
K
GNAPPS
E
V
L
----------------------
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
-
V
N
R
-
F
-
G
R
R
N
S
M
L
I
V
---
N
L
L
A
V
T
G
G
C
F
M
G
---------------
L
CKV---------------
A
-----
K
----
S
-------
V
E
M
L
----
I
L
G
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
-----------
P
M
Y
I
G
E
I
S
P
--
T
--
A
-
L
R
G
A
F
--
G
T
L
N
---
Q
L
G
I
V
V
G
I
----
L
V
A
Q
I
F
G
L
E
F
I
LG
S
--------------------------
E
--------------
E
-
L
W
-----------------
P
L
L
-------------
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
F
-
C
P
E
S
P
R
F
----
L
L
I
---
N
--------------------------------
R
K
------
E
E
E
N
A
K
Q
I
L
---------------
Q
R
L
------------------------
W
------------
G
T
Q
-
D
V
S
Q
D
I
Q
E
------------------------------------------------
M
-
K
D
E
-
S
A
R
---------------------------------------------
M
S
Q
E
K
Q
V
T
--------------------------
V
-
L
-
E
L
F
R
--
V
----
S
S
Y
---------
R
Q
P
I
----
I
I
S
-------
I
V
L
Q
L
-
S
Q
Q
L
SG
I
N
------
A
V
F
Y
Y
S
T
G
I
F
K
D
-------
A
G
---------
V
----
Q
E
----------
P
I
Y
A
T
-
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
--
G
R
-
R
T
L
------
H
M
I
G
L
G
G
M
---
A
F
C
S
T
L
M
T
V
----
S
--
L
L
L
KDNY
N
--------
G
--
M
S
F
V
C
----
I
G
--
A
I
L
V
F
V
A
F
F
-
E
I
G
-
P
G
-
P
I
P
W
F
I
V
A
E
L
F
-----------------
S
Q
G
P
--
R
P
A
-
A
M
A
V
-
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
-----
F
P
S
A
A
H
-----------------------------------------------------------------------------
21
HHSearch
55.76
13%
-161
- C7 -
4IKV
10
?
A:
[29-460]
--------------------------------------------------------------------
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
I
L
V
-
Y
Y
M
Y
YEVSKG
G
----
L
--------
G
--------------
L
----------------------
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
-
A
D
R
V
F
-
G
T
S
R
A
V
F
Y
G
---
G
L
L
I
M
A
G
H
I
A
L
A
---------------
I
------------------
P
-----
G
----
G
-------
V
A
A
L
----
F
V
S
M
A
L
I
V
L
G
T
G
L
----
L
K
P
N
V
-----------
S
S
I
V
G
D
M
Y
K
--
P
GD
D
-
R
R
D
A
G
--
F
S
I
F
---
Y
M
G
I
N
L
G
A
----
F
L
A
P
L
V
V
G
T
A
G
--
M
--------------------------
K
--------------
Y
-
N
F
-----------------
H
L
G
-------------
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
-
R
K
K
N
L
G
L
----
A
G
T
YVP
N
--------------------------------
P
L
------
T
P
A
E
K
K
K
A
A
-------
A
I
M
A
V
G
A
V
V
I
A
------------------------
V
------------
L
L
A
I
L
I
P
N
G
W
F
T
V
E
T
F
I
S
L
V
G
I
L
-----------------------------------
G
I
I
I
P
I
I
-
Y
F
V
---------------------------------------------
V
M
Y
R
S
P
K
T
--------------------------
T
-
A
E
E
R
S
R
--
V
----
I
A
Y
---------
I
P
L
F
----
V
A
S
-------
A
M
F
W
A
-
I
-----
Q
E
------
Q
G
S
T
I
L
A
N
Y
A
D
K
R
-
T
---
Q
L
D
---------
V
AG
I
H
L
S
----------
P
A
W
F
Q
-
S
L
N
P
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
--
G
K
-
R
Q
P
T
I
P
Q
K
-
F
A
L
G
L
L
F
A
---
G
L
S
F
I
V
I
L
V
----
P
--
G
------
H
L
S
GGG---
L
--
V
H
P
I
W
----
L
V
--
L
S
Y
F
I
V
V
L
G
-
E
L
C
-
L
S
-
P
V
G
L
S
A
T
T
K
L
A
-----------------
P
A
A
F
--
S
A
Q
-
T
M
S
L
-
W
F
L
S
N
A
A
A
Q
A
-
I
N
A
Q
L
-----
V
R
F
Y
T
P
-----------------------------------------------------------------------------
24
HHSearch
54.18
13%
-153
- C7 -
4J05
1
?
A:
[35-476]
--------------------------------------------------------------
K
L
V
L
L
A
G
V
G
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
-
M
L
A
Q
------
V
YFPK
T
--------
G
--------------
L
----------------------
P
A
Q
R
Q
D
L
M
K
A
A
A
N
I
G
C
V
V
G
Q
V
M
F
G
V
L
-
G
D
S
-
F
-
G
R
K
F
V
Y
G
K
E
---
L
I
L
I
I
V
A
T
I
F
Q
M
---------------
S
------------------
A
-----
P
----
S
HWD
G
N
R
V
L
T
W
I
----
T
I
C
R
V
F
L
G
I
G
I
G
G
----
D
Y
P
M
S
-----------
A
T
V
V
S
D
R
A
N
--
I
--
H
-
R
R
G
T
L
--
L
C
F
I
---
F
A
N
Q
G
W
G
S
----
F
V
G
S
L
V
T
I
V
T
I
--
S
--------------------------
G
F
K
H
RLKSGHTHD
V
D
K
-
A
W
-----------------
R
I
L
-------------
I
G
L
S
L
I
P
A
F
G
T
L
Y
Q
-
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
--------------------------
E
F
V
-
A
Y
F
S
--
T
WNHF
R
N
L
---------
L
G
S
M
----
L
G
W
-------
F
L
V
D
I
-
A
-----
F
Y
------
G
I
N
L
N
Q
S
V
V
L
A
Q
I
-----
G
F
A
---------
G
----
K
T
GD
V
Y
D
K
L
F
Q
L
A
T
G
N
I
-
I
V
T
A
L
G
F
L
P
G
Y
Y
F
T
L
F
L
I
D
I
V
--
G
R
-
K
K
L
------
Q
F
M
G
F
I
M
S
---
G
L
F
L
A
I
L
A
G
----
E
--
I
------
D
--------
H
I-
G
K
G
P
L
----
L
A
--
C
F
T
F
M
Q
F
F
F
-
N
F
G
-
A
N
-
T
T
T
F
I
V
A
A
E
L
F
-----------------
P
T
R
I
--
R
A
S
-
A
H
G
I
-
S
A
A
A
G
K
C
G
A
I
-
L
S
S
L
V
-----
F
N
Q
L
K
A
-----------------------------------------------------------------------------
18
HHSearch
54.07
12%
-149
- C7 -
4LDS
-
?
A:
[7-396]
--------------------------------------------------------------
L
I
F
I
L
G
A
L
G
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
-
F
I
H
K
------
D
----
I
--------
P
--------------
L
----------------------
N
S
T
T
E
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
-
A
D
K
-
L
-
G
R
R
R
L
V
M
L
I
---
A
I
V
F
I
I
G
A
L
I
L
A
---------------
A
------------------
S
-----
T
----
N
-------
L
A
L
L
----
I
I
G
R
L
I
I
G
L
A
V
G
G
----
S
M
S
T
V
-----------
P
V
Y
L
S
E
M
A
P
--
T
--
E
-
Y
R
G
S
L
--
G
S
L
N
---
Q
L
M
I
T
I
G
I
----
L
A
A
Y
L
V
N
Y
A
F
A
--
D
--------------------------
I
--------------
E
-
G
W
-----------------
R
W
M
-------------
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
-
Y
F
-
M
P
E
S
P
R
W
----
L
L
E
---
N
--------------------------------
R
N
------
E
E
A
A
R
Q
V
M
K
----------------
I
T
------------------------
Y
------------
D
D
S
-
E
I
D
K
E
L
K
----------------------------------------------------
E
M
-
K
E
I
---------------------------------------------
N
A
I
S
E
--
S
--------------------------
T
-
W
-
T
V
I
K
--
S
----
P
W
L
---------
G
R
I
L
I
V
G
C
I
F
A
-------
I
F
Q
Q
F
I
G
-----
I
N
------
A
V
I
F
Y
S
S
S
I
F
A
-
K
-
A
---
G
L
G
---------
E
----
A
A
----------
S
I
L
G
S
-
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
--
D
R
-
K
K
L
------
L
V
G
G
N
I
G
M
---
I
A
S
L
L
I
M
A
I
L
I
W
T
I
--
G
------
I
--------
A
--
S
S
A
W
I
----
I
I
--
V
C
L
S
L
F
I
V
F
-
F
G
I
-
S
W
G
P
V
L
W
V
M
L
P
E
L
F
-----------------
P
M
R
A
--
R
G
A
-
A
T
G
I
-
S
A
L
V
L
N
I
G
T
L
-
I
V
S
L
F
-----
F
P
I
L
S
D
-----------------------------------------------------------------------------
26
HHSearch
53.59
12%
-152
- C7 -
4TPH
3
?
A:
[17-449]
-------------------------------------------------------------------
V
S
L
I
E
L
W
E
R
F
G
Y
Y
G
M
Q
A
L
I
V
Y
F
M
V
Q
------
R
----
L
--------
G
--------------
F
----------------------
D
D
S
R
A
N
L
V
W
S
A
C
A
A
L
I
Y
V
S
P
A
I
G
G
W
V
-
G
D
K
-
I
L
G
T
K
R
T
M
L
L
G
---
A
G
I
L
S
V
G
Y
A
L
M
T
---------------
V
------------------
P
-----
T
E---
N
-------
T
W
F
M
----
F
S
A
L
G
V
I
V
V
G
N
G
L
----
F
K
P
N
A
-----------
G
N
L
V
R
K
I
Y
E
------S
K
I
D
S
A
--
F
T
I
Y
---
Y
M
A
V
N
V
G
S
----
T
F
S
M
L
L
T
P
W
I
K
--
D
--------------------------
Y
V
N
A
Q
Y
GNE------
F
-
G
W
-----------------
H
A
A
-------------
F
A
V
C
C
V
G
I
L
V
G
L
G
N
Y
A
-
L
-
M
H
K
S
L
A
N
----
Y
G
S
---
E
--------------------------------
P
D
------
T
R
P
V
N
K
K
S
L
A
I
V
L
A
L
A
A
L
-----
S
V
V
A
------------------------
S
------------
A
I
I
L
-
E
Y
E
D
V
A
R
V
---
F
V
Y
A
A
G
V
-----------------------------------
A
V
L
G
I
F
F
-
H
L
-----------------------------------------------------
E
--------------------------
R
-
A
-
G
L
I
A
--
A
----
L
------------
I
L
T
----
V
Q
T
-------
V
F
F
F
I
-
F
-----
Y
Q
------
Q
M
S
T
S
L
A
L
F
A
L
R
N
-
V
---
D
W
D
FQVFGTHLW
T
----
W
S
----------
P
A
Q
F
Q
-
A
L
N
P
I
W
I
M
V
L
S
P
V
L
A
W
---------I
A
A
K
------
F
A
L
G
F
A
V
V
---
A
I
G
F
F
I
Y
G
F
----
A
--
G
------
Q
FAVNG---
K
--
T
S
S
W
V
----
M
I
--
W
G
Y
A
S
Y
S
L
G
-
E
L
L
-
V
S
-
G
L
G
L
A
M
I
A
R
-----------------------------
M
M
G
A
-
Y
F
V
A
S
G
I
S
Q
Y
-
L
G
G
V
V
-----
A
N
F
A
S
V
-----------------------------------------------------------------------------
20
HHSearch
53.10
17%
-152
- C7 -
4U4V
7
NARK_ECOLI
A:
[64-430]
------------------------------------------------------------------------------------------
K
V
------
G
----
F
--------
N
--------------
F
----------------------
T
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
-
V
P
I
-
F
-
G
G
R
R
W
T
A
F
S
---
T
G
I
L
I
I
P
C
V
W
L
G
---------------
F
------------------
A
V
Q
D
TS
T
----
P
-------
Y
S
V
F
----
I
I
I
S
L
L
C
G
F
A
G
A
-----
N
F
A
S
S
-----------
M
A
N
I
S
F
F
F
P
--
K
--
Q
-
K
Q
G
G
A
--
L
G
L
N
---
G
G
L
G
N
M
G
V
----
S
V
M
Q
L
V
A
P
L
V
V
--
S
LSIFA---------------------
V
--------------
F
-
G
S
-----------------
Q
G
V
K
Q
PDGTELY
L
A
N
A
S
W
I
W
V
P
F
L
A
I
F
T
I
A
A
W
F
G
-
M
N
D
L
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
P
V
L
K
--
R
----
G
H
L
---------
W
I
M
S
----
L
L
Y
-------
L
A
T
F
G
-
S
-----
F
I
------
G
F
S
A
G
F
A
M
L
S
K
---
T
---
Q
F
P
---------
D
----
V
Q
----------
I
L
Q
Y
A
-
F
F
G
P
F
I
G
A
L
A
R
S
A
G
G
A
L
S
D
R
L
--
G
G
-
T
R
V
------
T
L
V
N
F
I
L
M
---
A
I
F
S
G
L
L
F
L
----
T
--
L
------
P
T-------
D
QG
G
S
F
M
A
F
F
A
V
F
L
--
A
L
F
L
T
A
G
L
G
-
S
G
S
-
T
F
-
Q
M
I
S
V
I
F
R
K
L
T
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
A
T
D
--
T
A
A
-
A
L
G
F
-
I
S
A
I
G
A
I
G
G
F
-
F
I
P
K
A
-----
F
G
S
S
L
A
-----------------------------------------------------------------------------
35
HHSearch
52.41
14%
-175
* C7 *
2CFQ
5
LACY_ECOLI
A:
[17-395]
------------------------------------------------------------------------
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
-
I
W
L
H
------
D
I---
N
--------
H
--------------
I
----------------------
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
-
S
D
K
-
L
-
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
---------------
F
------------------
G
-----
P
----
L
L
------
Q
Y
N
I
----
L
V
G
S
I
V
G
G
I
Y
L
G
F
CFNA
G
A
P
A
V
-----------
E
A
F
I
E
K
V
S
------
R
-
R
S
N
F
E
--
F
G
R
A
---
R
M
F
G
C
V
G
W
----
A
L
G
A
S
I
V
G
I
M
F
--
T
-----------------------------------------
I
-
N
N
-----------------
Q
F
V
-------------
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
-
F
-
A
K
T
D
A
P
S
----
S
A
T
---
V
--------------------------------
A
N
------
A
V
G
A
-------------------------------------------------------------------------------------------------------------------------------
N
H
---------------------------------------------
S
A
-
F
S
L
K
L
--------------------------
A
-
L
-
E
L
F
R
--
Q
----
P
K
L
---------
W
F
L
S
----
L
Y
V
-------
I
G
V
S
C
-
T
-----
Y
D
------
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
Q
G
---------
T
----
R
V
----------
F
G
Y
V
T
-
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
--
G
G
-
K
N
A
------
L
L
L
A
G
T
I
M
---
S
V
R
I
I
G
S
S
F
----
A
---------------------
T
S
A
L
E
----
V
V
--
I
L
K
T
L
H
M
F
E
-
V
P
F
-
L
L
-
V
G
C
F
K
Y
I
T
S
Q
F
-----------------
E
V
R
F
--
S
A
T
-
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
-----
A
G
N
M
Y
E
S
---------------------------
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
-----------------------------