@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03900: (2016-06-06 )
MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDLDGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGIAPGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKPYKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVMEPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDLITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLNERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAYANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA
Atome Classification :
(53 SA)
.........10........20........30----........40........50........60........70........---80-.--........90........100.......110.......120.......130------.--------.------...--------...140.-......150.......160.......170....--...180.......190...--....200..-.....210.......220.......230........240.......250.......260.......270........280....-.-..290.--......300.......----310.......320.......330--.........340.....-..350....--.-...360.......370.......380.......390.......400.......410.......420.......430....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQTTAS
I
T
T
A
Q
W
Q
Q
K
R
D
Q
F
V
S
KGVSNGN
R
S
----
L
A
V
KGEG
A
E
L
YDLDG
R
R
F
I
D
FAGAIGTLNVGHSH
P
K
V
V
E
A
V
K
R
Q
A
E
E
L
---I--H--PGF
N
V
M
M
Y
P
T
Y
I
E
L
A
E
K
L
CGIAPGSHE
K
K
A
I
F
LNS
G
A
E
A
V
E
N
A
V
K
I
A
R
K
Y
-------
T
--------
K
------RQ
G
--------
V
V
S
F
T
RG-FHGRT
N
M
T
M
SMTSKVK
P
Y
KFGFGPFA
P
E
VYQAP--FP
Y
Y
Y
QKPAGMSDE
S
Y
D
D
M
--
V
I
Q
A
F
N
D
F
F
-IASVAP
E
T
V
A
C
V
V
MEPVQGEG
G
F
I
I
P
S
-
K
R
F
V
Q
H
V
A
S
F
C
K
EH
G
I
V
F
V
A
D
E
IQTGFART
G
T
Y
F
A
I
E
HF-DVV
P
D
L
I
T
V
S
K
S
L
AAG-L-P
L
S
G
VI--G
R
A
E
M
LDAAAPGELGG----TYAGS
P
L
G
C
A
A
A
L
A
V
L
D
I
I
E
E----EGL
N
E
R
S
E
E
I
G
K
I
I
E
D
K
-
A
Y
E
-
W
K
Q
EF--P-
F
I
G
D
I
R
R
L
G
A
M
A
A
I
E
I
V
KDPDTREPDKTK
A
A
A
I
A
A
YANQN
G
L
L
L
L
TAGING
N
I
I
R
F
L
T
P
L
VI
S
D
S
L
L
N
E
G
L
S
I
L
E
A
G
LRA-
51
PsiBlast_CBE
88.22
44%
-111
- C1 -
4ATP
2
?
C:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
E
L
S---
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
47
PsiBlast_CBE
87.26
44%
-110
- C1 -
4ATP
2
?
H:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
----
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
10
PsiBlast_PDB
86.92
44%
-109
- C1 -
4ATP
2
?
A:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
E
L
S---
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
11
PsiBlast_PDB
86.20
44%
-109
- C1 -
4ATQ
4
?
A:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
E
L
S---
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
44
PsiBlast_CBE
86.17
44%
-107
- C1 -
4ATQ
4
?
C:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
E
L
S---
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
48
PsiBlast_CBE
86.02
44%
-109
- C1 -
4ATP
2
?
G:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
----
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
49
PsiBlast_CBE
85.95
44%
-110
- C1 -
4ATP
2
?
F:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
-----
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
46
PsiBlast_CBE
85.71
44%
-109
- C1 -
4ATP
2
?
J:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
-----
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
45
PsiBlast_CBE
85.43
44%
-109
- C1 -
4ATP
2
?
K:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
-----
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
28
PsiBlast_CBE
85.36
44%
-103
- C1 -
1SZU
16
GABT_ECOLI
C:
[3-417]
--------
S
N
K
E
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
----
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
---
S
--
H
--
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
-------
T
--------
K
------
R
S
G
--------
T
I
A
F
S
G
A
-
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
--
Y
P
C
P
L
H
---
G
I
S
E
----
D
D
--
A
I
A
S
I
H
R
I
F
-
K
N
D
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
-
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
A
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
-
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
-
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
----
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
----
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
-
L
L
A
-
I
A
E
K
H
--
P
-
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
R
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
-------
50
PsiBlast_CBE
85.28
44%
-109
- C1 -
4ATP
2
?
D:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
-----
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
30
PsiBlast_CBE
85.19
44%
-101
- C1 -
1SZK
17
GABT_ECOLI
D:
[3-417]
--------
S
N
K
E
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
----
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
---
S
--
H
--
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
-------
T
--------
K
------
R
S
G
--------
T
I
A
F
S
G
A
-
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
--
Y
P
C
P
L
H
---
G
I
S
E
----
D
D
--
A
I
A
S
I
H
R
I
F
-
K
N
D
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
S
G
G
F
Y
A
S
S
-
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
-
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
-
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
----
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
----
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
-
L
L
A
-
I
A
E
K
H
--
P
-
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
R
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
-------
43
PsiBlast_CBE
85.16
44%
-107
- C1 -
4ATQ
4
?
E:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
----
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
26
PsiBlast_CBE
84.66
44%
-103
- C1 -
1SF2
12
GABT_ECOLI
B:
[3-417]
--------
S
N
K
E
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
----
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
---
S
--
H
--
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
-------
T
--------
K
------
R
S
G
--------
T
I
A
F
S
G
A
-
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
--
Y
P
C
P
L
H
---
G
I
S
E
----
D
D
--
A
I
A
S
I
H
R
I
F
-
K
N
D
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
-
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
-
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
-
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
----
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
----
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
-
L
L
A
-
I
A
E
K
H
--
P
-
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
R
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
-------
42
PsiBlast_CBE
84.56
44%
-105
- C1 -
4ATQ
4
?
F:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
E
-GG
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
40
PsiBlast_CBE
84.39
44%
-107
- C1 -
4ATQ
2
?
H:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
----
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
36
PsiBlast_CBE
84.38
47%
-104
- C1 -
3Q8N
2
?
D:
[33-447]
-----------
E
L
Q
A
R
K
Q
S
A
V
A
A
G
V
G
V
T
L
P
V
----
Y
V
V
A
A
G
G
G
V
L
A
D
A
D
G
N
Q
L
I
D
F
G
S
G
I
A
V
T
T
V
G
N
S
A
P
A
V
V
D
A
V
T
Q
Q
V
A
A
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
K
V
A
E
H
L
N
R
L
T
P
G
D
H
E
K
R
T
A
L
F
N
S
G
A
E
A
V
E
N
A
V
K
I
A
R
A
Y
-------
T
--------
R
------
R
Q
A
--------
V
V
V
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
M
T
A
K
N
Q
P
Y
K
H
G
F
G
P
F
A
N
E
V
Y
R
V
P
--
T
S
Y
P
F
R
-----
D
G
E
T
D
G
A
A
--
A
A
A
H
A
L
D
L
I
-
N
K
Q
V
G
A
D
N
V
A
A
V
V
I
E
P
V
H
G
E
G
G
F
V
V
P
A
-
P
G
F
L
G
A
L
Q
K
W
C
T
D
N
G
A
V
F
V
A
D
E
V
Q
T
G
F
A
R
T
G
A
L
F
A
C
E
H
E
-
N
V
V
P
D
L
I
V
T
A
K
G
I
A
G
G
-
L
-
P
L
S
A
V
T
--
G
R
A
E
I
M
D
G
P
Q
S
G
G
L
G
G
----
T
Y
G
G
N
P
L
A
C
A
A
A
L
A
V
I
D
T
I
E
R
----
E
N
L
V
A
R
A
R
A
I
G
E
T
M
L
S
R
-
L
G
A
-
L
A
A
A
D
--
P
-
R
I
G
E
V
R
G
R
G
A
M
I
A
V
E
L
V
K
-
P
G
T
T
E
P
D
A
D
L
T
K
R
V
A
A
A
A
H
A
Q
G
L
V
V
L
T
C
G
T
Y
G
N
V
L
R
F
L
P
P
L
S
M
P
D
H
L
L
D
E
G
L
D
I
L
A
A
-----
23
PsiBlast_CBE
84.35
44%
-104
- C1 -
1SFF
8
GABT_ECOLI
B:
[3-417]
--------
S
N
K
E
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
----
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
---
S
--
H
--
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
-------
T
--------
K
------
R
S
G
--------
T
I
A
F
S
G
A
-
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
--
Y
P
C
P
L
H
---
G
I
S
E
----
D
D
--
A
I
A
S
I
H
R
I
F
-
K
N
D
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
-
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
-
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
-
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
----
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
----
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
-
L
L
A
-
I
A
E
K
H
--
P
-
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
R
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
-------
41
PsiBlast_CBE
84.32
44%
-107
- C1 -
4ATQ
2
?
G:
[32-454]
--------------
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
----
Y
V
E
D
A
D
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
---
T
--
H
--
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
-------
T
--------
G
------
R
D
A
--------
V
V
A
F
D
H
A
-
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
MS
Y
P
F
R
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
--
I
T
-----
M
I
-
E
K
Q
I
G
G
D
Q
V
A
A
I
I
I
E
P
I
Q
G
E
G
G
F
I
V
P
A
-
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
-
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
--
G
R
A
D
L
L
D
A
V
H
P
G
G
L
G
G
----
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
----
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
-
L
R
E
-
L
A
A
----
S
-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
-
P
G
S
K
E
P
N
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
21
PsiBlast_CBE
83.99
44%
-103
- C1 -
1SFF
15
GABT_ECOLI
D:
[3-417]
--------
S
N
K
E
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
----
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
---
S
--
H
--
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
-------
T
--------
K
------
R
S
G
--------
T
I
A
F
S
G
A
-
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
--
Y
P
C
P
L
H
---
G
I
S
E
----
D
D
--
A
I
A
S
I
H
R
I
F
-
K
N
D
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
-
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
-
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
-
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
----
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
----
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
-
L
L
A
-
I
A
E
K
H
--
P
-
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
R
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
-------
105
HHSearch
70.32
32%
-109
- C1 -
2OAT
2
OAT_HUMAN
A:
[40-437]
---------
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
-
Y
H
P
L
P
V
----
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
--
L
--
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
-------
G
Y
TVKGIQK
Y
------
K
A
K
--------
I
V
F
A
A
G
N
-
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
-
T
S
Y
D
G
F
G
P
F
M
P
G
F
D
I
I
P
--
Y
N
-------------------
D
L
P
A
L
E
R
A
L
-
Q
----
D
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
----
D
-
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
E
T
K
D
------
W
D
A
W
K
V
C
L
R
L
R
D
N
G
L
L
A
K
P
T
H
--
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
--
127
Fugue
69.69
31%
-113
- C1 -
2OAT
2
OAT_HUMAN
A:
[36-439]
---
G
P
P
T
S
D
--
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
-----
H
PLPV
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
-
S
Q
V
D
K
---
L
---TL
T
S
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
-
Y
I
T
K
L
F
--
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
-------
G
--------
Y
------
T
V
K
GIQKYK
A
K
I
V
F
A
A
G
N
-
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
-
Y
D
G
F
G
P
F
M
P
G
F
D
I
I
P
--
Y
N
D
-------------------
L
P
A
L
E
R
A
L
-
Q
D
P
----
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N-
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
---
G
-EHGS
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
-----D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
E
T
K
------
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
L
L
A
K
P
T
H
--
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
114
HHSearch
69.04
31%
-108
* C1 *
4NOG
3
?
A:
[35-418]
--------------------------
A
P
V
P
V
----
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
---
T
--
L
--
T
L
-
R
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
---
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
-------
A
Y
E
VKEIPP
D
------
S
A
K
--------
V
I
L
C
N
N
N
-
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
-
D
C
Y
N
N
F
G
P
F
T
P
G
F
E
L
I
D
--
Y
D
-------------------
D
V
G
A
L
E
E
A
L
-
K
----
D
P
N
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
-
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
-
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
--
G
R
A
D
V
M
D
V
L
K
P
G
T
H
G
S
----
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
-
L
R
R
E
L
Y
G
K
V
--
P
-
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D
S
D
A
I
-------
D
P
N
D
V
V
M
K
L
K
E
N
G
I
L
S
K
P
T
R
--
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
K
S
F
L
--
106
HHSearch
68.07
31%
-110
- C1 -
4JF1
9
ARGD_SALTY
A:
[27-416]
---------------
T
F
D
E
V
I
L
P
V
-
Y
A
P
A
D
F
----
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
---
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
C
V
R
HSP--
F
------
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
--
F
N
-------------------
D
L
H
A
V
K
A
V
M
-
D
-----
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
------
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
----
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
-
L
Q
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
------
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
--
76
PsiBlast_CBE
67.67
32%
-114
- C1 -
2BYL
1
OAT_HUMAN
C:
[64-432]
--------------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
LT
S
--
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
------
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
GYTVKGI
Q
--------
K
------
Y
K
A
--------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
-
G
F
G
P
F
M
P
-----------------
G
F
D
I
I
P
Y
N
D
L
PA
L
E
R
A
L
Q
D
---------
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
F
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
D
-----
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
------
K
E
T
K
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
-------
69
PsiBlast_CBE
66.76
32%
-112
- C1 -
1OAT
2
OAT_HUMAN
A:
[64-432]
--------------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
LT
S
--
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
------
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
TVKGI
Q
--------
K
------
Y
K
A
--------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
-
G
F
G
P
F
M
P
-----------------
G
F
D
I
I
P
Y
N
D
L
P
A
L
E
R
A
L
Q
D
---------
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
D
-----
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
------
K
E
T
K
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
-------
81
PsiBlast_CBE
66.38
35%
-109
- C1 -
2E54
5
ARGD_THEMA
A:
[15-366]
-------------------------------------
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
---
I
--
H
--
C
S
-
N
L
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
K
N
T
F
G
G
---
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
-------
G
--------
K
------
K
K
S
EKKY
R
---
I
L
S
A
H
N
S
-
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
-
Y
Q
K
P
F
E
P
L
V
P
-----
G
--
F
E
Y
F
--------------------
E
F
N
N
V
E
D
L
R
R
K
M
S
E
D
V
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
-
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
-
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
V
I
V
N
E
R
A
N
V
L
E
---
P
G
D
H
G
T
----
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
----
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
-
L
Q
E
-
M
K
E
E
Y
--
D
-
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
R
E
E
V
S
N
R
E
--------
V
A
T
K
C
F
E
N
K
L
L
V
V
P
A
G
--
N
N
T
I
R
F
L
P
P
L
T
V
-------------------
67
PsiBlast_CBE
66.38
32%
-110
- C1 -
1OAT
1
OAT_HUMAN
C:
[64-432]
--------------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
LT
S
--
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
------
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
GYTVKGI
Q
--------
K
------
Y
K
A
--------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
-
G
F
G
P
F
M
P
-----------------
G
F
D
I
I
P
Y
N
D
L
PA
L
E
R
A
L
Q
D
---------
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
D
-----
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
------
K
E
T
K
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
-------
66
PsiBlast_CBE
66.18
32%
-108
- C1 -
2OAT
2
OAT_HUMAN
A:
[64-432]
--------------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
LT
S
--
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
------
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
TVKGI
Q
--------
K
------
Y
K
A
--------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
-
G
F
G
P
F
M
P
-----------------
G
F
D
I
I
P
Y
N
D
L
P
A
L
E
R
A
L
Q
D
---------
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
D
-----
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
------
K
E
T
K
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
-------
78
PsiBlast_CBE
66.06
32%
-111
- C1 -
2BYL
2
OAT_HUMAN
A:
[64-432]
--------------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
LT
S
--
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
------
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
TVKGI
Q
--------
K
------
Y
K
A
--------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
-
G
F
G
P
F
M
P
-----------------
G
F
D
I
I
P
Y
N
D
L
P
A
L
E
R
A
L
Q
D
---------
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
F
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
D
-----
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
------
K
E
T
K
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
-------
77
PsiBlast_CBE
65.40
32%
-112
- C1 -
2BYL
2
OAT_HUMAN
B:
[64-432]
--------------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
LT
S
--
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
------
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
GYTVKGI
Q
--------
K
------
Y
K
A
--------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
-
G
F
G
P
F
M
P
-----------------
G
F
D
I
I
P
Y
N
D
L
PA
L
E
R
A
L
Q
D
---------
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
F
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
D
-----
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
------
K
E
T
K
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
-------
65
PsiBlast_CBE
65.11
32%
-109
- C1 -
2OAT
2
OAT_HUMAN
B:
[64-432]
--------------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
LT
S
--
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
------
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
GYTVKGI
Q
--------
K
------
Y
K
A
--------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
-
G
F
G
P
F
M
P
-----------------
G
F
D
I
I
P
Y
N
D
L
PA
L
E
R
A
L
Q
D
---------
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
D
-----
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
------
K
E
T
K
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
-------
64
PsiBlast_CBE
65.02
32%
-109
- C1 -
2OAT
1
OAT_HUMAN
C:
[64-432]
--------------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
LT
S
--
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
------
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
GYTVKGI
Q
--------
K
------
Y
K
A
--------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
-
G
F
G
P
F
M
P
-----------------
G
F
D
I
I
P
Y
N
D
L
PA
L
E
R
A
L
Q
D
---------
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
D
-----
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
------
K
E
T
K
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
-------
68
PsiBlast_CBE
64.91
32%
-111
- C1 -
1OAT
2
OAT_HUMAN
B:
[64-432]
--------------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
---
T
LT
S
--
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
------
N
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
GYTVKGI
Q
--------
K
------
Y
K
A
--------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
-
G
F
G
P
F
M
P
-----------------
G
F
D
I
I
P
Y
N
D
L
PA
L
E
R
A
L
Q
D
---------
P
N
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
-
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
-
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
--
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
----
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
-
L
M
K
-
L
P
S
D
-----
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
------
K
E
T
K
D
W
D
A
W
K
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
-------
82
PsiBlast_CBE
62.66
32%
-103
- C1 -
4JEY
13
ARGD_SALTY
B:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
63
PsiBlast_CBE
61.65
32%
-104
- C1 -
4JEW
11
ARGD_SALTY
A:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
89
PsiBlast_CBE
61.31
32%
-102
- C1 -
4ZWM
11
?
A:
[58-418]
--------------------------------------
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
TLT
L
--
R
--
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
-------
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
-------
A
Y
E
VKEIPP
D
------
S
A
K
--------
V
I
L
C
N
N
N
-
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
-
N
F
G
P
F
T
P
-----------------
G
F
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
K
D
---------
P
N
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
-
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
-
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
--
G
R
A
D
V
M
D
V
L
K
P
G
T
H
G
S
----
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
-
L
Y
G
K
V
--
P
-
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
--
D
S
D
A
I
D
P
N
D
-----
V
V
M
K
L
K
E
N
G
--
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
-----------------
88
PsiBlast_CBE
61.12
32%
-99
- C1 -
4ZWM
9
?
B:
[58-418]
--------------------------------------
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
TLT
L
--
R
--
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
-------
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
-------
A
Y
E
VKEIPP
D
------
S
A
K
--------
V
I
L
C
N
N
N
-
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
-
N
F
G
P
F
T
P
-----------------
G
F
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
K
D
---------
P
N
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
-
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
-
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
--
G
R
A
D
V
M
D
V
L
K
P
G
T
H
G
S
----
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
-
L
Y
G
K
V
--
P
-
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
--
D
S
D
A
I
D
P
N
D
-----
V
V
M
K
L
K
E
N
G
--
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
-----------------
94
PsiBlast_CBE
60.91
32%
-103
- C1 -
4JEZ
13
ARGD_SALTY
B:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
79
PsiBlast_CBE
60.90
32%
-100
- C1 -
4JF1
9
ARGD_SALTY
B:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
62
PsiBlast_CBE
60.58
32%
-100
- C1 -
4JEW
13
ARGD_SALTY
B:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
59
PsiBlast_CBE
60.54
32%
-102
- C1 -
2PB2
5
ARGD_SALTY
B:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
------
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
90
PsiBlast_CBE
60.32
32%
-98
- C1 -
4ZLV
6
?
B:
[58-418]
--------------------------------------
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
TLT
L
--
R
--
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
-------
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
-------
A
YEVKEIPP
D
------
S
A
K
--------
V
I
L
C
N
N
N
-
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
-
N
F
G
P
F
T
P
-----------------
G
F
E
L
I
D
Y
D
D
V
GA
L
E
E
A
L
K
D
---------
P
N
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
-
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
-
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
--
G
R
A
D
V
M
D
V
L
K
P
G
T
H
G
S
----
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
-
L
Y
G
K
V
--
P
-
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
--
D
S
D
A
I
D
P
N
D
-----
V
V
M
K
L
K
E
N
G
--
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
-----------------
85
PsiBlast_CBE
60.24
32%
-99
- C1 -
5EQC
7
?
A:
[58-418]
--------------------------------------
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
TLT
L
--
R
--
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
-------
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
-------
A
Y
E
VKEIPP
D
------
S
A
K
--------
V
I
L
C
N
N
N
-
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
-
N
F
G
P
F
T
P
-----------------
G
F
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
K
D
---------
P
N
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
-
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
-
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
--
G
R
A
D
V
M
D
V
L
K
P
G
T
H
G
S
----
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
-
L
Y
G
K
V
--
P
-
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
--
D
S
D
A
I
D
P
N
D
-----
V
V
M
K
L
K
E
N
G
--
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
-----------------
58
PsiBlast_CBE
60.20
32%
-103
- C1 -
4JEX
17
ARGD_SALTY
B:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
92
PsiBlast_CBE
60.05
32%
-97
- C1 -
4NOG
6
?
B:
[43-403]
--------------------------------------
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
TLT
L
--
R
--
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
-------
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
-------
A
Y
E
VKEIPP
D
------
S
A
K
--------
V
I
L
C
N
N
N
-
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
-
N
F
G
P
F
T
P
-----------------
G
F
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
K
D
---------
P
N
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
-
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
-
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
--
G
R
A
D
V
M
D
V
L
K
P
G
T
H
G
S
----
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
-
L
Y
G
K
V
--
P
-
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
--
D
S
D
A
I
D
P
N
D
-----
V
V
M
K
L
K
E
N
G
--
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
-----------------
91
PsiBlast_CBE
60.01
32%
-98
- C1 -
4ZLV
5
?
A:
[58-418]
--------------------------------------
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
TLT
L
--
R
--
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
-------
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
-------
A
Y
E
VKEIPP
D
------
S
A
K
--------
V
I
L
C
N
N
N
-
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
-
N
F
G
P
F
T
P
-----------------
G
F
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
K
D
---------
P
N
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
-
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
-
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
--
G
R
A
D
V
M
D
V
L
K
P
G
T
H
G
S
----
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
-
L
Y
G
K
V
--
P
-
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
--
D
S
D
A
I
D
P
N
D
-----
V
V
M
K
L
K
E
N
G
--
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
-----------------
19
PsiBlast_PDB
59.96
32%
-103
- C1 -
4JEX
17
ARGD_SALTY
A:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
80
PsiBlast_CBE
59.62
32%
-101
- C1 -
4JF1
9
ARGD_SALTY
A:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
------
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
84
PsiBlast_CBE
59.58
32%
-98
- C1 -
5EQC
8
?
B:
[58-418]
--------------------------------------
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
TLT
L
--
R
--
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
-------
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
-------
A
Y
E
VKEIPP
D
------
S
A
K
--------
V
I
L
C
N
N
N
-
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
-
N
F
G
P
F
T
P
-----------------
G
F
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
K
D
---------
P
N
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
-
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
-
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
--
G
R
A
D
V
M
D
V
L
K
P
G
T
H
G
S
----
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
-
L
Y
G
K
V
--
P
-
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
--
D
S
D
A
I
D
P
N
D
-----
V
V
M
K
L
K
E
N
G
--
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
-----------------
83
PsiBlast_CBE
59.42
32%
-104
- C1 -
4JEY
13
ARGD_SALTY
A:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
----
H
G
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
95
PsiBlast_CBE
59.30
32%
-103
- C1 -
4JEZ
14
ARGD_SALTY
A:
[42-408]
-----------------------------------
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
---
W
--
H
--
T
S
-
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
---
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
-------
A
--------
C
V
R
HSPF
K
T
K
--------
I
I
A
F
H
N
A
-
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
-----------------
K
P
A
--------
D
I
--
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
-
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
-
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
----
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
-----
A
-
I
D
E
Q
F
--
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
------
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
93
PsiBlast_CBE
59.16
32%
-98
- C1 -
4NOG
3
?
A:
[43-403]
--------------------------------------
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
TLT
L
--
R
--
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
-------
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
-------
A
Y
E
VKEIPP
D
------
S
A
K
--------
V
I
L
C
N
N
N
-
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
-
N
F
G
P
F
T
P
-----------------
G
F
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
K
D
---------
P
N
V
A
A
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
-
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
-
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
--
G
R
A
D
V
M
D
V
L
K
P
G
T
H
G
S
----
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
-
L
Y
G
K
V
--
P
-
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
--
D
S
D
A
I
D
P
N
D
-----
V
V
M
K
L
K
E
N
G
--
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
-----------------