@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03910: (2016-06-06 )
MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKTSANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKRVYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAPDTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKILMKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHESIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAGGTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPYGLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIEPYLETKYLSIGL
Atome Classification :
(21 SA)
.........10........20........30........--40........50........60........70........80..-......90........100.......110.......120.......130.......140.......150.......160.......170.......180....---...190-.........200.......210.......220.......230.......240.......250.......260.......270.......280.......290.-.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPDQ
L
T
V
YNPAT
G
E
E
I
K
TIP
Q
Q
S
A
T
E
V
E
E
A
I
E
R
S
H
Q
A
F
K
--
T
WSKTSA
N
E
R
T
S
L
L
K
K
W
Y
E
L
I
V
E
H
K
E
E
L
A
D
L
I
T
KENGK
P
Y
Q
E
A
V
-
G
E
V
L
YG
A
G
Y
I
E
W
F
A
E
E
A
K
R
V
YGRTVPAPTTG
K
R
I
V
V
TRQPVGP
V
A
A
ITPWNF
P
N
A
M
I
TRKAAPALAAG
C
T
F
I
I
KPAPDTP
L
S
A
Y
E
L
A
R
L
A
Y
EAGI
P
K
D
V
L
Q
V
V
---IGD
G
---
E
E
I
G
N
V
FTSSP
K
I
R
K
I
T
FTGSTP
V
G
K
I
L
MKNSADT
V
K
H
V
S
M
ELGGHA
P
L
I
VDEDAD
I
D
L
A
V
E
Q
A
M
A
S
K
Y
RNAGQ
T
C
V
CAN
R
L
I
V
H
E
S
I
K
D
E
F
A
A
K
L
S
E
Q
V
S
-
K
-
L
KVGNG
L
E
EGVNVGPII
N
K
R
G
F
E
K
I
V
S
Q
I
D
D
A
V
E
KG
A
K
V
I
AGGTYDRNDDK
G
C
Y
F
VN
P
T
V
L
TDVDTS
M
N
I
M
HEETFGPVAP
I
V
T
F
S
D
I
D
E
A
I
Q
LANDTPY
G
L
A
A
Y
F
FTENYRR
G
I
Y
ISENL
E
Y
G
I
I
G
WNDGGPSAVQAPFGGMKESGIGREGGSEG
I
E
P
Y
LE
T
K
Y
L
SIGL
26
PsiBlast_CBE
89.39
55%
-74
- C4 -
3EK1
2
?
F:
[50-499]
----
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
-
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
P
A
P
Q
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
---
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
-
E
-
L
K
V
G
N
G
T
E
P
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
-----
K
E
L
G
G
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
---
27
PsiBlast_CBE
89.36
55%
-73
- C4 -
3EK1
2
?
E:
[50-499]
----
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
-
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
P
A
P
Q
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
---
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
-
E
-
L
K
V
G
N
G
T
E
P
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
-----
K
E
L
G
G
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
---
25
PsiBlast_CBE
89.14
55%
-74
- C4 -
3EK1
2
?
G:
[50-499]
----
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
-
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
P
A
P
Q
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
---
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
-
E
-
L
K
V
G
N
G
T
E
P
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
-----
K
E
L
G
G
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
---
24
PsiBlast_CBE
88.74
55%
-74
- C4 -
3EK1
2
?
H:
[50-499]
----
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
-
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
P
A
P
Q
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
---
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
-
E
-
L
K
V
G
N
G
T
E
P
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
-----
K
E
L
G
G
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
---
29
PsiBlast_CBE
88.65
55%
-73
- C4 -
3EK1
2
?
C:
[50-499]
----
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
-
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
P
A
P
Q
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
---
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
-
E
-
L
K
V
G
N
G
T
E
P
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
-----
K
E
L
G
G
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
---
30
PsiBlast_CBE
88.59
55%
-74
- C4 -
3EK1
2
?
B:
[50-499]
----
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
-
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
P
A
P
Q
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
---
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
-
E
-
L
K
V
G
N
G
T
E
P
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
-----
K
E
L
G
G
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
---
28
PsiBlast_CBE
88.53
55%
-74
- C4 -
3EK1
2
?
D:
[50-499]
----
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
-
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
P
A
P
Q
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
---
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
-
E
-
L
K
V
G
N
G
T
E
P
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
-----
K
E
L
G
G
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
---
130
HHSearch
87.59
56%
-73
- C4 -
3EK1
2
?
A:
[47-500]
-
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
-
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
P
A
P
Q
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
---
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
-
E
-
L
K
V
G
N
G
T
E
P
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
----
L
G
G
L
-
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
--
2
PsiBlast_PDB
87.24
55%
-73
- C4 -
3EK1
2
?
A:
[50-499]
----
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
-
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
P
A
P
Q
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
---
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
-
E
-
L
K
V
G
N
G
T
E
P
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
-----
K
E
L
G
G
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
---
22
PsiBlast_CBE
87.19
51%
-66
- C4 -
3JZ4
1
GABD_ECOLI
C:
[25-481]
--
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
--
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
-
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
P
G
H
Q
A
D
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
---
T
G
S
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
Q
A
M
S
-
K
-
L
H
I
G
D
G
L
D
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
---
K
A
H
E
R
G
G
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
G
L
21
PsiBlast_CBE
86.93
51%
-65
- C4 -
3JZ4
1
GABD_ECOLI
D:
[25-481]
--
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
--
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
-
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
P
G
H
Q
A
D
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
---
T
G
S
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
Q
A
M
S
-
K
-
L
H
I
G
D
G
L
D
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
---
K
A
H
E
R
G
G
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
G
L
4
PsiBlast_PDB
86.61
48%
-77
- C4 -
2W8O
9
SSDH_HUMAN
A:
[30-485]
------
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
--
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
-
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
K
D
R
R
A
L
V
L
K
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
R
K
N
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
C
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
-
K
N
L
R
V
G
N
G
F
E
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
---
K
R
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
-----
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
C
Y
G
-
3
PsiBlast_PDB
86.42
48%
-70
- C4 -
2W8N
7
SSDH_HUMAN
A:
[30-485]
------
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
--
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
-
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
K
D
R
R
A
L
V
L
K
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
R
K
N
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
C
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
-
K
N
L
R
V
G
N
G
F
E
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
---
K
R
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
C
Y
G
-
1
PsiBlast_PDB
86.27
51%
-63
- C4 -
3JZ4
1
GABD_ECOLI
A:
[25-481]
--
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
--
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
-
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
P
G
H
Q
A
D
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
---
T
G
S
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
Q
A
M
S
-
K
-
L
H
I
G
D
G
L
D
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
---
K
A
H
E
R
G
G
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
G
L
128
HHSearch
86.24
51%
-64
- C4 -
3JZ4
1
GABD_ECOLI
A:
[24-479]
-
G
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
--
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
-
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
P
G
H
Q
A
D
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
---
T
G
S
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
Q
A
M
S
-
K
-
L
H
I
G
D
G
L
D
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
K
A
--
H
E
R
G
G
N
-
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
--
7
PsiBlast_PDB
85.88
48%
-70
- C4 -
2W8R
10
SSDH_HUMAN
A:
[30-485]
------
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
--
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
-
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
K
D
R
R
A
L
V
L
K
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
R
K
N
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
A
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
-
K
N
L
R
V
G
N
G
F
E
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
---
K
R
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
C
Y
G
-
5
PsiBlast_PDB
85.76
48%
-67
- C4 -
2W8P
8
SSDH_HUMAN
A:
[30-485]
------
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
--
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
-
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
K
D
R
R
A
L
V
L
K
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
R
K
N
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
A
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
-
K
N
L
R
V
G
N
G
F
E
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
---
K
R
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
C
Y
G
-
118
HHSearch
85.69
48%
-69
- C4 -
2W8N
7
SSDH_HUMAN
A:
[25-484]
-
A
A
T
F
P
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
--
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
-
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
K
D
R
R
A
L
V
L
K
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
---
P
C
S
R
KN
A
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
C
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
K
N
-
L
R
V
G
N
G
F
E
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
K
R
--
H
Q
L
G
K
N
-
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
C
Y
--
6
PsiBlast_PDB
85.50
48%
-68
- C4 -
2W8Q
9
SSDH_HUMAN
A:
[30-485]
------
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
--
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
-
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
K
D
R
R
A
L
V
L
K
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
R
K
N
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
A
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
-
K
N
L
R
V
G
N
G
F
E
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
---
K
R
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
C
Y
G
-
23
PsiBlast_CBE
85.06
51%
-64
- C4 -
3JZ4
1
GABD_ECOLI
B:
[25-481]
--
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
--
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
-
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
P
G
H
Q
A
D
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
---
T
G
S
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
Q
A
M
S
-
K
-
L
H
I
G
D
G
L
D
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
---
K
A
H
E
R
G
G
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
G
L
131
HHSearch
79.37
36%
-76
- C4 -
3B4W
10
?
A:
[23-481]
-
S
D
V
I
E
V
R
C
P
A
T
G
E
Y
V
G
K
V
P
M
A
A
A
A
D
V
D
A
A
V
A
A
A
R
A
A
F
D
NG
P
W
P
S
T
P
P
H
E
R
A
A
V
I
A
A
A
V
K
M
L
A
E
R
K
D
L
F
T
K
L
L
A
A
E
T
G
Q
P
P
T
I
I
E
T
M
H
W
M
G
S
M
G
A
M
N
Y
F
A
G
A
A
D
K
V
T
W
T
E
T
R
-
T
G
S
Y
G
Q
S
I
V
S
R
E
P
V
G
V
V
G
A
I
V
A
W
N
V
P
L
F
L
A
V
N
K
I
A
P
A
L
L
A
G
C
T
I
V
L
K
P
A
A
E
T
P
L
T
A
N
A
L
A
E
V
F
A
E
V
G
L
P
E
G
V
L
S
V
V
---
P
G
-
G
---
I
E
T
G
Q
A
L
T
S
N
P
D
I
D
M
F
T
F
T
G
S
S
A
V
G
R
E
V
G
R
R
A
A
E
M
L
K
P
C
T
L
E
L
G
G
K
S
A
A
I
I
L
E
D
V
D
L
A
A
A
I
P
M
M
V
F
S
G
V
M
N
A
G
Q
G
C
V
N
Q
T
R
I
L
A
P
R
S
R
Y
D
E
I
V
A
A
V
T
N
F
V
T
-
A
-
L
P
V
G
P
P
S
D
P
A
A
Q
I
G
P
L
I
S
E
K
Q
R
T
R
V
E
G
Y
I
A
K
G
I
E
E
G
A
R
L
V
C
G
G
G
R
P
E
G
L
D
N
G
F
-
F
I
Q
P
T
V
F
A
D
V
D
N
K
M
T
I
A
Q
E
E
I
F
G
P
V
L
A
I
I
P
Y
D
T
E
E
D
A
I
A
I
A
N
D
S
V
Y
G
L
A
G
S
V
W
T
T
D
V
P
K
G
I
K
I
S
Q
Q
I
R
T
G
T
Y
G
I
N
W
Y
A
-
F
D
P
G
S
P
F
G
G
Y
K
N
S
G
I
G
R
E
N
G
P
E
G
V
E
H
F
T
Q
Q
K
S
V
L
L
P
-