@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04150: (2016-06-07 )
MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGITTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTSKSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNFKDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVFTENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAINALSYKLDQDQWFRIFTAVQGYDIP
Atome Classification :
(20 SA)
......--.-..10........20...--.----.-...30---.........40........50...-.-------....60........----70........80........90........100.......110.......120......-.130..-------------------.-----------------.....140.......150.......160......-.170-.----.----..----.....180-........190.......200.......210...----------..--------------------------..220..--------------------------.----------------------....230.....-..--240-----.......250.......260.......270.......-280.........290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQR
I
Q
L
--
A
-
E
D
L
Q
F
S
R
V
I
H
G
L
W
RLNE--W----N-Y
S
D
A
----
E
L
L
S
L
I
E
W
C
I
DHGITTFDHADIYG-G-------
Y
T
C
E
K
L
FG
N
A
L
ALS----PG
L
R
E
N
I
E
L
V
T
KC
G
I
V
L
ESPERPAHRSHHYNT
S
K
S
H
I
L
A
S
V
E
Q
S
L
M
N
L
R
T
D
Y
I
D
M
L
L
I
H-RPD-PL-------------------M-----------------
D
P
E
G
V
A
E
A
F
Q
A
L
KCSG
K
V
R
Y
F
GVSNF
K
D
H
Q
Y
R
M
L
-
E
S
---Y----L----
P
E
----
K
L
V
TN
Q
I
--
E
L
S
A
Y
E
L
E
N
M
L
D
G
T
L
N
L
C
Q
EKRIPPMAWSPLAG
G
----------
K
V
--------------------------FTENTD
K
--------------------------
D
----------------------
R
R
V
R
T
A
L
E
S
V
Q
G-EI--G
A
A
-----
S
L
D
E
V
M
Y
A
W
L
YTHPAGI
M
P
IVGSG
K
R
E
R
I
S
A
A
I
N
A
L
S-Y--KL
D
Q
D
Q
W
F
R
I
F
T
A
VQGYDIP
1
PsiBlast_PDB
95.19
51%
-133
- C- -
4R9O
-
?
A:
[2-293]
V
Q
R
V
T
I
--
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
M
D
--
W
----
N
-
M
S
A
R
----
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
T
L
A
----
P
H
L
R
E
K
L
Q
I
V
T
K
C
G
I
A
--
T
T
A
R
A
E
N
K
L
G
H
Y
I
T
D
R
R
H
I
I
L
S
A
E
Q
S
L
K
N
L
A
T
D
Y
L
D
M
L
L
I
H
-
R
P
D
-
P
L
-------------------
M
-----------------
D
A
D
D
V
A
E
A
F
Q
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
T
L
L
-
Q
S
---
R
----
L
----
P
F
----
T
L
A
T
N
Q
V
--
E
I
S
P
V
H
Q
P
L
L
L
D
G
T
L
D
Q
L
Q
Q
L
R
I
R
P
M
A
W
S
C
L
G
G
G
----------
R
L
--------------------------
F
--
N
D
E
A
--------------------------
Y
----------------------
Q
P
L
R
Q
E
L
S
V
I
A
Q
-
E
L
--
N
A
S
-----
S
I
E
Q
V
V
Y
A
W
I
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
L
E
A
E
T
-
L
--
S
L
T
R
Q
Q
W
F
R
I
R
K
A
A
L
-----
2
PsiBlast_PDB
94.84
50%
-123
- C6 -
1OG6
1
YDHF_ECOLI
A:
[2-298]
V
Q
R
I
T
I
--
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
M
D
--
W
----
N
-
M
S
A
R
----
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
K
L
A
----
P
H
L
R
E
R
M
E
I
V
S
K
C
G
I
A
--
T
T
A
R
E
E
N
V
I
G
H
Y
I
T
D
R
D
H
I
I
K
S
A
E
Q
S
L
I
N
L
A
T
D
H
L
D
L
L
L
I
H
-
R
P
D
-
P
L
-------------------
M
-----------------
D
A
D
E
V
A
D
A
F
K
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
A
L
L
-
Q
S
---
R
----
L
----
P
F
----
T
L
A
T
N
Q
V
--
E
I
S
P
V
H
Q
P
L
L
L
D
G
T
L
D
Q
L
Q
Q
L
R
V
R
P
M
A
W
S
C
L
G
G
G
----------
R
L
--------------------------
F
--
N
D
D
Y
--------------------------
F
----------------------
Q
P
L
R
D
E
L
A
V
V
A
E
-
E
L
--
N
A
G
-----
S
I
E
Q
V
V
N
A
W
V
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
V
E
A
E
T
-
L
--
K
M
T
R
Q
Q
W
F
R
I
R
K
A
A
L
G
Y
D
V
P
21
PsiBlast_CBE
94.37
50%
-120
- C6 -
1OG6
1
YDHF_ECOLI
C:
[2-298]
V
Q
R
I
T
I
--
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
M
D
--
W
----
N
-
M
S
A
R
----
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
K
L
A
----
P
H
L
R
E
R
M
E
I
V
S
K
C
G
I
A
--
T
T
A
R
E
E
N
V
I
G
H
Y
I
T
D
R
D
H
I
I
K
S
A
E
Q
S
L
I
N
L
A
T
D
H
L
D
L
L
L
I
H
-
R
P
D
-
P
L
-------------------
M
-----------------
D
A
D
E
V
A
D
A
F
K
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
A
L
L
-
Q
S
---
R
----
L
----
P
F
----
T
L
A
T
N
Q
V
--
E
I
S
P
V
H
Q
P
L
L
L
D
G
T
L
D
Q
L
Q
Q
L
R
V
R
P
M
A
W
S
C
L
G
G
G
----------
R
L
--------------------------
F
--
N
D
D
Y
--------------------------
F
----------------------
Q
P
L
R
D
E
L
A
V
V
A
E
-
E
L
--
N
A
G
-----
S
I
E
Q
V
V
N
A
W
V
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
V
E
A
E
T
-
L
--
K
M
T
R
Q
Q
W
F
R
I
R
K
A
A
L
G
Y
D
V
P
3
PsiBlast_PDB
94.34
49%
-121
- C6 -
1UR3
-
YDHF_ECOLI
M:
[2-298]
V
Q
R
I
T
I
--
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
M
D
--
W
----
N
-
M
S
A
R
----
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
K
L
A
----
P
H
L
R
E
R
M
E
I
V
S
K
C
G
I
A
--
T
T
A
R
E
E
N
V
I
G
H
Y
I
T
D
R
D
H
I
I
K
S
A
E
Q
S
L
I
N
L
A
T
D
H
L
D
L
L
L
I
H
-
R
P
D
-
P
L
-------------------
M
-----------------
D
A
D
E
V
A
D
A
F
K
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
A
L
L
-
Q
S
---
R
----
L
----
P
F
----
T
L
A
T
N
Q
V
--
E
I
S
P
V
H
Q
P
L
L
L
D
G
T
L
D
Q
L
Q
Q
L
R
V
R
P
M
A
W
S
C
L
G
G
G
----------
R
L
--------------------------
F
--
N
D
D
Y
--------------------------
F
----------------------
Q
P
L
R
D
E
L
A
V
V
A
E
-
E
L
--
N
A
G
-----
S
I
E
Q
V
V
N
A
W
V
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
V
E
A
E
T
-
L
--
K
M
T
R
Q
Q
W
F
R
I
R
K
A
A
L
G
Y
D
V
P
27
HHSearch
94.12
52%
-133
- C- -
4R9O
-
?
A:
[2-293]
V
Q
R
V
T
I
--
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
M
D
--
W
----
N
-
M
S
A
R
----
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
T
L
A
----
P
H
L
R
E
K
L
Q
I
V
T
K
C
G
I
A
T
T
A
R
A
E
--
N
K
L
G
H
Y
I
T
D
R
R
H
I
I
L
S
A
E
Q
S
L
K
N
L
A
T
D
Y
L
D
M
L
L
I
H
-
R
P
D
-
P
L
-------------------
M
-----------------
D
A
D
D
V
A
E
A
F
Q
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
T
L
L
-
Q
S
---
R
----
L
----
P
F
----
T
L
A
T
N
Q
V
--
E
I
S
P
V
H
Q
P
L
L
L
D
G
T
L
D
Q
L
Q
Q
L
R
I
R
P
M
A
W
S
C
L
G
G
G
----------
R
L
--------------------------
F
N
D
E
A
Y
Q
--------------------------------------------------
P
L
R
Q
E
L
S
V
I
A
Q
-
E
L
--
N
A
S
-----
S
I
E
Q
V
V
Y
A
W
I
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
L
E
A
E
T
-
L
--
S
L
T
R
Q
Q
W
F
R
I
R
K
A
A
L
-----
22
PsiBlast_CBE
92.68
50%
-122
- C6 -
1OG6
1
YDHF_ECOLI
B:
[2-298]
V
Q
R
I
T
I
--
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
M
D
--
W
----
N
-
M
S
A
R
----
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
K
L
A
----
P
H
L
R
E
R
M
E
I
V
S
K
C
G
I
A
--
T
T
A
R
E
E
N
V
I
G
H
Y
I
T
D
R
D
H
I
I
K
S
A
E
Q
S
L
I
N
L
A
T
D
H
L
D
L
L
L
I
H
-
R
P
D
-
P
L
-------------------
M
-----------------
D
A
D
E
V
A
D
A
F
K
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
A
L
L
-
Q
S
---
R
----
L
----
P
F
----
T
L
A
T
N
Q
V
--
E
I
S
P
V
H
Q
P
L
L
L
D
G
T
L
D
Q
L
Q
Q
L
R
V
R
P
M
A
W
S
C
--------------
R
L
--------------------------
F
--
N
D
D
Y
--------------------------
F
----------------------
Q
P
L
R
D
E
L
A
V
V
A
E
-
E
L
--
N
A
G
-----
S
I
E
Q
V
V
N
A
W
V
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
V
E
A
E
T
-
L
--
K
M
T
R
Q
Q
W
F
R
I
R
K
A
A
L
G
Y
D
V
P
6
PsiBlast_PDB
74.80
25%
-135
- C6 -
3UYI
-
PERR_RAUSE
A:
[1-309]
M
P
R
V
K
L
--
G
T
Q
G
L
E
V
S
K
L
G
F
G
C
M
G
L
S
---
G
----------LP
E
E
Q
G
I
A
V
I
K
E
A
F
N
C
G
I
T
F
F
D
T
S
D
I
Y
G
E
N
-------
G
S
N
E
E
L
L
G
K
A
L
K
Q
L
----
P
--
R
E
K
I
Q
V
G
T
K
F
G
I
-----
H
E
I
G
F
S
G
V
K
A
K
G
T
P
D
Y
V
R
S
C
C
E
A
S
L
K
R
L
D
V
D
Y
I
D
L
F
Y
I
H
-
R
I
D
-
T
T
-------------------
V
-----------------
P
I
E
I
T
M
G
E
L
-
K
L
V
E
E
G
K
I
K
Y
V
G
L
S
E
A
S
P
D
T
I
R
R
A
-
H
A
---
V
----
H
----
P
------
V
T
A
L
Q
I
--
E
Y
S
L
W
-
T
R
D
I
E
D
E
I
V
P
L
C
R
Q
L
G
I
G
I
V
P
Y
S
P
I
G
R
G
L
F
AG
K
A
I
K
E
S----------------------------------
K
--------------------------
N
----------------------
K
Q
I
Y
Y
R
I
E
A
L
S
Q
-
K
H
--
G
C
T
-----
P
V
-
Q
L
A
L
A
W
V
L
H
Q
G
E
D
V
V
P
I
P
G
T
T
K
I
K
N
L
H
N
N
V
G
A
L
K
-
V
--
K
L
T
K
E
D
L
K
E
I
S
D
A
V
------
34
HHSearch
69.12
26%
-108
- C6 -
1PZ1
1
GS69_BACSU
A:
[1-312]
M
E
Y
T
S
I
--
A
D
T
G
I
E
A
S
R
I
G
L
G
T
W
A
I
G
G
TM
W
----
G
G
T
D
E
K
----
T
S
I
E
T
I
R
A
A
L
D
Q
G
I
T
L
I
D
T
A
P
A
Y
G
-
F
-------
G
Q
S
E
E
I
V
G
K
A
I
K
E
Y
-----
M
K
R
D
Q
V
I
L
A
T
K
T
A
L
D
W
K
N
N
------
Q
L
F
R
H
A
N
R
A
R
I
V
E
E
V
E
N
S
L
K
R
L
Q
T
D
Y
I
D
L
Y
Q
V
H
-
W
P
D
-
P
L
-------------------
V
-----------------
P
I
E
E
T
A
E
V
M
K
E
L
Y
D
A
G
K
I
R
A
I
G
V
S
N
F
S
I
E
Q
M
D
T
F
-
R
A
---
V
----------
A
----
P
L
H
T
I
Q
P
--
P
Y
N
L
F
E
R
E
M
E
-
E
S
V
L
P
Y
A
K
D
N
K
I
T
T
L
L
Y
G
S
L
C
R
G
----------
L
L
--------------------------
T
G
K
M
T
E
E
--------------------------
Y
T
F
E
G
DDLRNHDPKFQKPR
F
K
E
Y
L
S
A
V
N
Q
L
D
K
L
A
K
T
R
Y
--
G
-
K
-----
S
V
I
H
L
A
V
R
W
I
L
D
Q
P
G
A
D
I
A
L
W
G
A
R
K
P
G
Q
L
E
A
L
S
E
I
T
G
-
W
--
T
L
N
S
E
D
Q
K
D
I
N
T
I
L
E
N
----
33
HHSearch
67.97
25%
-111
- C6 -
1PYF
3
IOLS_BACSU
A:
[2-310]
-
K
K
A
K
L
--
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
G
G
--
H
NLYP
N
-
L
N
E
E
----
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
-
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
------
F
N
R
E
D
V
V
I
A
T
K
A
A
H
R
K
Q
G
N
------
D
F
V
F
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
-
F
P
D
-
E
H
-------------------
T
-----------------
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
E
Q
L
K
E
A
-
N
K
---
D
----------
G
----
L
V
D
V
L
Q
G
--
E
Y
N
L
L
N
R
E
A
E
-
K
T
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
----------
L
L
--------------------------
A
G
K
Y
T
E
D
--------------------------
T
T
F
P
EGDLRNEQEHFKG
E
R
F
K
E
N
I
R
K
V
N
K
L
A
P
I
A
E
-
K
H
--
N
-
V
-----
D
I
P
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
L
S
Q
E
D
I
S
F
I
D
K
L
F
A
-----
29
HHSearch
67.76
22%
-106
- C6 -
1LQA
1
TAS_ECOLI
A:
[1-344]
M
Q
Y
H
R
I
--
P
H
S
S
L
E
V
S
T
L
G
L
G
T
M
T
F
G
E
--
Q
------
N
S
E
A
----
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
-
V
PPRPETQ
G
L
T
E
T
Y
V
G
N
W
L
A
K
H
-----
G
S
R
E
K
L
I
I
A
S
K
V
S
G
P
S
R
N
N
D
K
--
G
I
R
P
D
Q
A
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
-
W
P
Q
-
R
P
-------------------
T
NCFGKL
G
Y
S
W
T
DSAPAV
S
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
-
L
H
---
L
A
D
K
H
D
----
L
P
----
R
I
V
T
I
Q
N
--
P
Y
S
L
L
N
R
S
F
E
-
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
----------
T
L
--------------------------
T
G
K
Y
L
N
G
--------------------------
A
KPAGA
R
N
T
L
F
SRFTRYSG
E
Q
T
-
Q
K
A
V
A
A
Y
V
D
I
A
R
-
R
H
--
G
-
L
-----
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
L
S
E
D
V
L
A
E
I
E
A
V
H
Q
V
Y
T
Y
P
32
HHSearch
67.33
22%
-108
- C6 -
3LUT
1
KCAB2_RAT
A:
[37-358]
Q
F
Y
R
N
L
--
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
G
--
G
----
Q
-
I
T
D
E
----
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
----
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-------
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
-
R
P
D
-
P
N
-------------------
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
-
Y
S
---
V
A
R
Q
F
N
----
L
I
----
P
P
I
C
E
Q
A
--
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
----------
I
V
--------------------------
S
G
K
Y
D
S
G
IPPYSRASLKGY
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
----------------------
Q
A
K
L
K
E
L
Q
A
I
A
E
-
R
L
--
G
-
C
-----
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
---
50
Fugue
66.98
21%
-106
- C6 -
1QRQ
1
KCAB2_RAT
A:
[1-325]
L
Q
F
Y
R
N
LG
K
-
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
G
--
G
----
Q
-
I
T
D
E
----
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
----
G
W
R
R
S
S
L
V
I
T
T
K
I
F
-------
W
G
G
K
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
-
R
P
D
-
P
N
-------------------
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
-
Y
S
---
V
----
A
----
R
Q
F
NLI
P
P
I
C
E
Q
A
--
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
----------
I
V
SGKYDSG
I
P
P
Y
S
RASLKGY
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
--------------------------
Q
----------------------
Q
A
K
L
K
E
L
Q
A
I
A
E
-
R
L
--
G
C
------
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
Y
-
28
HHSearch
66.75
22%
-111
- C6 -
3EAU
3
KCAB2_RAT
A:
[3-323]
Q
F
Y
R
N
L
--
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
G
--
G
----
Q
-
I
T
D
E
----
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
----
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-------
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
-
R
P
D
-
P
N
-------------------
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
-
Y
S
---
V
----
A
R
Q
F
N
L
I
----
P
P
I
C
E
Q
A
--
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
----------
I
V
--------------------------
S
G
K
Y
D
S
G
IPPYSRASLKGY
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
----------------------
Q
A
K
L
K
E
L
Q
A
I
A
E
-
R
L
--
G
-
C
-----
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
----
31
HHSearch
65.56
22%
-109
- C6 -
3N6Q
1
GPR_ECOLI
A:
[13-336]
M
Q
Y
R
Y
C
--
G
K
S
G
L
R
L
P
A
L
S
L
G
L
W
H
N
F
G
--
H
----
V
-
N
A
L
E
----
S
Q
R
A
I
L
R
K
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
G
-
P
PP-----
G
S
A
E
E
N
F
G
R
L
L
R
E
D
F---
A
A
Y
R
D
E
L
I
I
S
T
K
A
G
Y
D
M
W
P
G
------
P
Y
G
S
G
G
S
R
K
Y
L
L
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
S
H
-
R
V
D
-
E
N
-------------------
T
-----------------
P
M
E
E
T
A
S
A
L
A
H
A
V
Q
S
G
K
A
L
Y
V
G
I
S
S
Y
S
P
E
R
T
Q
K
M
-
V
E
L
L
R
E
----
W
----
K
I
----
P
L
L
I
H
Q
P
--
S
Y
N
L
L
N
R
W
V
D
K
S
G
L
L
D
T
L
Q
N
N
G
V
G
C
I
A
F
T
P
L
A
Q
G
----------
L
L
--------------------------
T
G
K
Y
L
-----------------------------LT
E
A
N
-----------------
L
N
S
L
R
L
L
N
E
M
A
Q
-
Q
R
--
G
-
Q
-----
S
M
A
Q
M
A
L
S
W
L
L
K
D
D
R
V
T
S
V
L
I
G
A
S
R
A
E
Q
L
E
E
N
V
Q
A
L
N
N
L
--
T
F
S
T
K
E
L
A
Q
I
D
Q
H
I
A
D
G
E
--
41
HHSearch
65.28
24%
-117
- C6 -
4WGH
2
?
A:
[25-298]
K
K
T
V
R
F
--
G
-
E
Q
A
A
V
P
A
I
G
L
G
T
W
Y
M
G
E
--
H
----
A
-
A
Q
R
Q
----
Q
E
V
A
A
L
R
A
G
I
D
H
G
L
T
V
I
D
T
A
E
M
Y
A
-
D
-------
G
G
A
E
E
V
V
G
Q
A
I
R
G
-------
L
R
D
R
V
V
L
V
S
K
V
Y
P
W
--------------
H
A
G
K
A
A
M
H
R
A
C
E
N
S
L
R
R
L
Q
T
D
Y
L
D
M
Y
L
L
H
-
W
R
G
-
D
I
-------------------------------------
P
L
Q
E
T
V
E
A
M
E
K
L
V
A
E
G
K
I
R
R
W
G
V
S
N
L
D
T
E
D
M
Q
A
L
-
W
R
---
T
----
A
D---
G
E
----
H
C
A
T
N
Q
V
--
L
Y
H
L
A
S
R
G
I
E
-
Y
D
L
L
P
W
C
Q
Q
H
S
L
P
V
M
A
Y
C
P
L
A
Q
A
----------
G
R
--------------------------
L
R
D
G
L
----------------------------------------------------
F
Q
H
S
D
I
I
N
M
A
N
-
A
R
--
G
-
I
-----
T
V
A
Q
L
L
L
A
W
V
I
R
H
P
G
V
L
-
A
I
P
K
A
A
S
I
E
H
V
V
Q
N
A
A
A
L
D
-
I
--
V
L
S
G
E
E
L
A
Q
L
D
R
L
Y
P
P
P
Q
--
30
HHSearch
65.08
23%
-131
- C6 -
1YNP
13
?
A:
[21-311]
M
K
K
R
Q
L
--
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
S
L
G
T
----------
D
E
T
----
K
A
R
R
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
N
-
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
-------
R
R
Q
D
I
I
L
A
T
K
V
-------------------
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
-
G
G
T
-
I
D
-------------------
D
-----------------
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
P
N
V
I
K
E
Y
-
L
K
---
R
----------
S
----
N
I
V
S
I
M
M
--
Q
Y
S
I
L
D
R
R
P
E
E
--
W
F
P
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
----------
L
L
--------------------------
S
R
R
P
L
P
E
--------------------------
G
EGYL------------------
N
Y
R
Y
D
E
L
K
L
L
R
E
-
S
L
PT
D
-
R
-----
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
A
T
--
P
L
T
A
E
E
R
Q
H
I
Q
K
L
A
K
A
A
V
--
46
HHSearch
65.07
27%
-98
- C6 -
3O0K
4
?
A:
[26-282]
V
P
T
V
K
L
--
N
-
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
------------
S
N
D
----
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
-----------
N
E
E
G
V
G
K
A
I
N
G
S
----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
--------------
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
-
W
P
M
-
P
S
-------------------
K
D
----------------
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
-
I
K
---
E
----
S
----
G
V
----
T
P
V
L
N
Q
I
--
E
L
H
P
Q
F
Q
Q
D
E
---
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
Q
G
-----------
L
--------------------------
L
E
D
P
---------------------------------------------------------
T
L
K
S
I
A
E
-
K
H
--
A
-
K
-----
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
--
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
-
F
--
T
L
N
G
T
D
H
D
A
I
T
K
L
-------
12
PsiBlast_PDB
64.97
26%
-120
- C6 -
4WGH
2
?
A:
[28-286]
---
V
R
F
--
G
-
E
Q
A
A
V
P
A
I
G
L
G
T
W
Y
M
G
E
--
H
----
A
-
A
Q
R
Q
----
Q
E
V
A
A
L
R
A
G
I
D
H
G
L
T
V
I
D
T
A
E
M
Y
A
-
D
-------
G
G
A
E
E
V
V
G
Q
A
I
R
-------
G
L
R
D
R
V
V
L
V
S
K
V
--------------
Y
P
W
H
A
G
K
A
A
M
H
R
A
C
E
N
S
L
R
R
L
Q
T
D
Y
L
D
M
Y
L
L
H
W
R
G
D
I
P
L
-------------------
Q
-----------------
E
---
T
V
E
A
M
E
K
L
V
A
E
G
K
I
R
R
W
G
V
S
N
L
D
T
E
D
M
Q
A
L
W
R
T
---
A
----
D
----
G
E
----
H
C
A
T
N
Q
V
L
Y
H
L
A
S
R
G
I
E
Y
D
L
---
L
P
W
C
Q
Q
H
S
L
P
V
M
A
Y
C
P
L
A
----------------------------------------------
Q
--------------------------
A
----------------------
G
R
L
R
D
G
L
F
Q
H
S
D
-
I
I
--
N
M
A
N
A
R
GI
T
V
A
Q
L
L
L
A
W
V
I
R
H
P
-
G
V
L
A
I
P
K
A
A
S
I
E
H
V
V
Q
N
A
A
A
L
D
-
I
--
V
L
S
G
E
E
--------------
36
HHSearch
64.40
23%
-104
- C6 -
3N2T
-
?
A:
[3-317]
S
D
T
I
R
I
--
P
G
I
D
T
P
L
S
R
V
A
L
G
T
W
A
I
G
G
WM
W
----
G
G
P
D
D
D
----
N
G
V
R
T
I
H
A
A
L
D
E
G
I
N
L
I
D
T
A
P
V
Y
G
-
F
-------
G
H
S
E
E
I
V
G
R
A
L
A
E
-------
K
P
N
K
A
H
V
A
T
K
L
G
L
H
W
V
G
E
D
-
E
K
N
M
K
V
F
R
D
S
R
P
A
R
I
R
K
E
V
E
D
S
L
R
R
L
R
V
E
T
I
D
L
E
Q
I
H
-
W
P
D
-
D
K
-------------------
T
-----------------
P
I
D
E
S
A
R
E
L
Q
K
L
H
Q
D
G
K
I
R
A
L
G
V
S
N
F
S
P
E
Q
M
D
I
F
-
R
E
---
V
----------
A
----
P
L
A
T
I
Q
P
--
P
L
N
L
F
E
R
T
I
E
-
K
D
I
L
P
Y
A
E
K
H
N
A
V
V
L
A
Y
G
A
L
C
R
G
----------
L
L
--------------------------
T
G
K
M
N
R
D
--------------------------
T
T
F
P
KDDLRSNDPKFQK
P
N
F
E
K
Y
L
A
A
M
D
E
F
E
K
L
A
E
-
K
R
--
G
-
K
-----
S
V
M
A
F
A
V
R
W
V
L
D
Q
G
P
V
-
I
A
L
W
G
A
R
K
P
G
Q
V
S
G
V
K
D
V
F
G
-
W
--
S
L
T
D
E
E
K
K
A
V
D
D
I
L
A
R
H
V
--
48
HHSearch
62.33
21%
-111
- C6 -
4HBK
-
?
A:
[1-290]
M
E
P
L
K
M
--
N
-
N
G
R
S
I
P
V
I
G
L
G
T
W
N
S
P
------------
P
G
----
E
V
G
A
A
V
K
K
A
L
E
I
G
Y
R
H
L
D
C
A
Y
V
Y
R
-----------
N
E
A
E
I
G
E
A
L
E
N
A
L
N
S
L
R
L
K
R
E
D
I
F
I
T
S
K
L
W
N
T
--------------
F
F
R
P
E
H
V
R
K
A
C
E
E
T
L
K
N
L
R
L
N
Y
L
D
L
Y
L
I
H
-
W
P
V
-
P
L
KHGGDL
F
P
T
D
SNGQLC
L
D
N
V
-----------------
P
H
E
D
T
W
K
E
M
E
K
L
V
D
E
G
L
V
K
S
I
G
L
S
N
F
N
K
R
Q
I
Q
N
I
-
L
E
---
H
----
C
----
R
I
----
K
P
A
N
L
Q
I
--
E
I
H
A
N
F
P
N
I
---
K
L
V
E
Y
A
Q
S
V
G
L
T
V
T
A
Y
A
P
L
G
---------------------------------------------
N
L
--------------------------------------------------
L
T
K
P
C
V
L
E
I
A
H
-
R
H
--
K
-
K
-----
T
P
A
Q
V
L
L
R
Y
L
L
Q
R
K
L
I
--
V
V
P
K
S
V
T
F
K
R
I
E
E
N
F
Q
V
F
D
-
F
--
Q
L
S
N
E
E
M
H
E
L
N
T
E
S
L
N
E
---