@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04230: (2016-06-07 )
MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSLFNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPSFVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKRLFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSVLADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF
Atome Classification :
(20 SA)
---------------------------------------------------------------........-----.10..-..-...-..20........30..-.....-.40........50........60.....-..--------.70.......------------.80.-----...--.--...90-......-----..100-....---.-....-110...-.-..----.120..------....--------.-130-----........140-----.-..--------....-.-------150...----....----.160....-...-170..---....-.180.------......190-------........200.......---------210...----------....-.220.......230-------------------.-....-...240.......250-----.........260.-.......-----------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------MHV
I
T
T
Q
V
-----
L
F
-
I
F
-
C
F
-
L
L
L
-
I
H
S
I
E
T
L
A
Y
A
TRLSGA-
R
V
G
F
I
-
A
S
A
L
S
L
F
N
V
M
V
I
V
S
R
M
S
N
M
V
QQPFTGHL-ID--------DAGK
N
A
L
A
I
V
------------GE
Q
F
-----
R
F
L
--
I
--FGS
T
V
-
G
T
I
L
G
I
-----
I
L
L
---
P
S
F
V
---
A
-
L
F
S
R
-
A
I
I
H
LA-G-G
G
----
G
S
V
F
Q
V
------
F
R
K
G
--------F-SK------
Q
G
F
K
N
A
L
S
Y
L------R-LP--------S
I
S
Y
-
V
-------
K
G
-
F
H
M
----
R
L
I
P
----
K
R
L
F
V
I
N
M
-
L
I
T
-
S
I
Y
T
I
---
G
V
L
S
-
A
L
Y
A
G
------LLAPER
S
T
--------
T
A
V
M
A
S
G
L
I
N
G
I
A
T
M
L
L
A
---------IF-VDP----------
K
V
S
V
-
L
A
D
D
V
AKGKR
S
Y
I
--------------------
Y
-
L
K
W
T-S
V
T
M
V
T
S
R
V
A
G
T
L
L
-------
A
Q
L
M
FIP
G
A
Y
Y
-
I
-
A
W
L
T
KWF-----------------------------------------------------------------------------------------------
32
Fugue
75.14
19%
-135
* C5 *
4PE6
1
?
A:
[18-339]
---------------------------------------------------------------
K
P
F
I
A
L
S
N
-----
G
F
-
I
G
N
G
W
-
R
Q
T
M
I
A
K
F
E
E
A
A
K
Q
A
Q
A
D
G
L
I
G
K
Y
K
V
-
V
N
A
P
G
N
N
S
A
T
E
Q
V
A
Q
I
K
S
L
L
L
Q
K
P
D
A
L
L
-
I
N
--------
P
A
S
P
T
A
L
Q
P
V
------------
I
Q
Q
A
C
D
A
G
V
K
V
V
--
V
--
F
D
S
A
I
-
D
A
P
C
A
Y
-----
I
L
Q
---
N
S
F
V
D
W
A
T
-
Y
A
A
K
-
P
V
L
E
S
I
-
G
-
G
K
----
G
N
V
I
V
V
R
G
VVGS
Q
P
E
A
--------
E
M
Y
E
------
T
T
K
K
I
L
A
E
Y
P
------
Q
-
V
K
--------
T
V
A
T
-
V
-------
T
G
M
C
D
G
----
A
T
A
Q
----
K
A
V
L
G
V
L
P
-
S
V
S
-
T
V
D
A
V
I
G
C
G
D
G
Y
-
G
V
A
Q
A
------
F
A
T
A
G
K
P
I
--------
P
A
V
T
F
E
--
T
N
G
R
A
L
S
Y
W
K
D
N
KIDNG
S
V
A
V
M
S
D
P
----------
A
Q
S
V
-
A
A
L
W
A
A
L
D
L
L
E
G
R
--------------------
D
-
L
P
K
Q
M
T
F
P
I
V
L
I
E
E
K
D
R
D
T
-------
W
A
S
V
L
K
P
D
E
Y
A
-
A
W
P
W
T
R
E
L
F
R
Q
Q
V
E
A
I
K
T
GGEPVQPPIPST--------------------------------------------------------------------------
33
Fugue
62.62
21%
-133
- C2 -
5CAJ
3
?
A:
[16-276]
------------------------------------------------------------PRG
S
H
-------------------
M
L
I
L
-
I
S
P
A
K
T
L
D
Y
Q
S
P
L
T
T
T
-
R
-----
Y
T
L
P
E
L
L
D
N
S
Q
Q
L
I
H
E
A
R
K
L
T
P
P
Q
I
S
T
L
M
R
I
--------
S
--
D
K
L
A
G
I
N
------------
A
A
R
F
-----
H
D
W
------------------------
Q
---
P
D
F
T
---
P
-
A
N
A
R
Q
A
I
L
A
F
K
-
G
-
D
V
----
Y
T
G
L
Q
A
------
E
T
----------
F
-
S
E
------
D
D
F
D
F
A
Q
Q
H
L
------
R
M
L
S
--------
G
L
Y
G
-
V
LRPL
D
L
M
Q
P
-
Y
R
L
E
MGI
R
L
E
N
----
A
R
G
K
D
L
Y
Q
-
F
W
G
-
D
I
I
T
N
---
K
L
N
E
-
A
L
A
A
Q
G
D
N
V
V
I
N
L
A
S
D
E
Y
F
--------
K
S
V
K
P
K
K
L
N
---
A
E
I
I
K
P
---------
V
F
-
L
D
E
----------
K
N
G
K
-
F
K
I
I
S
F
Y
A
K
K
A
R
G
--------------------
L
M
S
R
F
I
-
I
E
N
R
L
T
K
P
E
Q
L
T
G
F
-------
N
S
E
G
Y
F
F
D
E
D
S
-
S
-
S
N
G
E
L
V
F
K
R
Y
E-------------------------------------------------------------------------------------------
35
Fugue
50.78
14%
-181
- C1 -
4MTN
2
?
A:
[5-406]
-----------------------GN
E
V
L
R
I
V
D
S
I
H
R
D
KSID
K
E
I
V
F
E
G
V
E
Q
A
I
L
S
A
A
R
K
H
FGE
E
E
V
I
E
V
H
I
D
RTSG
Q
P
M
V
K
-
T
N
-
G
R
E
-
I
D
R
D
E
L
G
D
I
L
G
R
I
S
-
A
-
Q
T
K
Q
V
M
I
Q
K
I
R
E
A
E
R
D
T
L
F
D
E
Y
A
Q
L
R
G
Q
I
V
S
G
T
V
-
T
R
NEGS
A
I
T
V
N
I
G
K
A
E
A
I
L
P
RSEMIPG
E
S
H
R
P
N
E
R
I
-----
R
A
V
--
V
--
L
E
V
K
K
M
G
P
R
V
R
V
-----
V
L
S
RAH
P
D
F
V
---
R
R
L
L
E
L
-
E
I
P
E
V
N
-
E
-
R
I
----
I
E
I
R
S
L
------
A
R
E
A
G
Y
R
T
K
V
A
V
S
-
C
A
------
D
S
N
I
D
P
V
G
A
C
V
GVRG
A
R
-
I
R
--------
N
V
G
E
E
L
-------
G
G
-
E
R
I
----
E
V
V
R
W
N
DS
L
Q
V
L
V
P
N
A
M
Q
P
S
-
E
V
E
D
V
---
I
L
C
P
M
L
G
R
V
L
------
V
L
V
R
D
D
Q
L
--------
S
L
A
I
G
K
---
R
G
Q
N
V
R
L
A
S
---------
K
L
-
V
G
W
----------
D
I
D
V
M
T
R
E
E
L
D
Q
Q
L
D
Q
A
V
--------------------
V
--
A
Y
S
-
Q
I
P
G
V
S
E
E
L
A
E
G
L
V
S
Q
GFLS
F
E
D
L
S
V
I
E
P
D
E
L
M
E
M
G
S
L
T
Q
E
Q
A
D
V
I
V
E
Y
A
E
R
E
S
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R
I
E
K
E
Q
D
L
R
R
A
T
E
K
A
ERQSQE-------------------------------------------------------------
38
Fugue
49.63
28%
-297
* C2 *
2KJF
-
CCLA_CARML
A:
[1-60]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
--
A
--
Y
G
I
A
Q
-
G
T
A
E
K
V
-----
V
S
L
---
I
N
-
A
---
G
-
L
T
V
G
-
S
I
I
S
I
L
-
G
-
G
V
TVGL
S
G
V
F
T
A
------
V
K
A
A
--------
I
-
A
K
------
Q
G
I
K
K
A
I
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
49.55
12%
-176
- C5 -
4I6M
6
ARP9_YEAST
B:
[3-439]
PFRQDS
I
L
I
I
Y
P
R
SQ
T
T
L
V
Q
F
G
LNEETFTVPE
L
E
I
P
T
Q
I
Y
R
T
T
R
QD
G
S
Y
T
Y
H
STNKDNK
A
E
L
I
K
P
I
Q
N
G
E
I
-----
I
D
-
I
S
-
A
F
-
T
Q
F
-
L
R
L
I
F
V
S
I
L
S
D
R
A
N
K
N
-
Q
D
A
F
E
-
A
E
L
S
N
I
P
L
L
L
I
T
H
H
S
W
S
Q
S
D
L
E
I
I
T
Q
Y
V
-
F
E
--------
S
L
E
I
N
N
L
I
Q
L
------------
P
A
S
L
-----
A
A
T
--
Y
S
M
I
S
L
Q
N
-
C
C
I
I
D
V
G
TH
H
T
D
I
I
---
P
I
V
D
---
Y
-
A
Q
L
D
-
H
L
V
S
S
I
-
P
M
G
G
----
Q
S
I
N
D
S
------
L
K
K
L
--------
L
-
P
Q
WD
D
D
Q
I
E
S
L
K
K
S
P
I
F
E
------
V
-
L
S
KNSDLE
F
N
T
F
W
D
-
E
-------
K
G
-
N
E
I
----
K
V
G
K
----
Q
R
F
Q
G
C
N
N
-
L
I
K
-
N
I
S
N
R
---
V
G
L
T
-
L
D
N
I
D
------
D
I
N
K
A
K
A
V
W
E
N
I
I
I
V
G
G
T
T
S
I
S
G
F
K
E
A
L
L
G
Q
L
L
K
---------
D
H
-
L
I
I
----------
E
P
E
E
-
E
K
S
K
R
E
E
E
A
K
S
F
V
P
T
I
E
Y
VQCPT
V
I
K
L
AKYPDY
F
-
P
E
W
K
-
K
S
G
Y
S
E
I
I
F
L
G
A
Q
I
-------
V
S
K
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F
T
H
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-
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-
F
Y
I
T
R
E
K
Y
N
M
KGPAALWDVQF---------------------------------------------------------------------------------
37
Fugue
48.33
15%
-108
- C2 -
4IC4
-
OSH3_YEAST
A:
[625-996]
---------------------------------------------------------K
S
V
T
R
R
N
D
I
P
E
A
A
A
-----
S
P
-
P
S
-
L
L
-
S
F
L
-
R
K
N
V
G
K
D
L
S
S
I
A
M
P
V
T
-
S
N
E
P
I
-
S
I
L
Q
L
I
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E
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F
E
Y
A
P
L
L
T
K
A
T
Q
R
P
D
P
I
T
F
-
V
S
--------
A
F
A
I
S
F
L
S
I
Y
------------
R
D
K
T
-----
R
T
L
RK
P
--
F
N
P
L
L
-
A
E
T
F
E
L
-----
I
R
E
---
D
M
G
F
---
R
-
L
I
S
E
-
K
V
S
H
------
R
----
P
P
V
F
A
F
------
F
A
E
H
--------
L
-
D
-----------
W
E
C
S
Y
T
------
V
-
T
P
--------
S
Q
K
F
---------
W
G
-
K
S
I
----
E
L
N
N
----
E
G
I
L
R
L
K
F
-
K
T
T
G
E
L
F
E
W
---
T
Q
P
T
-
T
I
L
K
N
------
L
I
A
G
E
R
Y
M
--------
E
P
V
N
E
F
E
V
H
S
S
K
G
D
K
S
H
I
---------
L
F
-
D
K
A
G
M
FSGRSE
G
F
K
V
S
I
-
I
P
P
P
S
S
N
R
K
K
E
T
L
--------------------
A
-
G
K
W
T
-
Q
-
S
L
A
N
E
T
T
H
E
T
I
W
-------
E
V
G
D
L
V
S
N
P
K
K
-
K
-
Y
G
F
T
K
F
T
A
N
L
NEITEIEKGNLPPTDSRLR
P
D
I
R
A
Y
E
E
GN
V
D
K
A
E
E
W
K
L
K
L
E
Q
L
Q
R
E
R
R
N
K
GQDVEPKYFEKVSKN
E
W
K
Y
I
T
G
PKS
Y
W
E
R
R
K
K
HDWSDISQLW
34
Fugue
48.04
12%
-154
- C2 -
1U55
3
?
A:
[1-188]
---------------------------------------------------------------
M
K
G
T
I
V
G
T
-----
W
I
-
K
T
-
L
R
-
D
L
Y
G
N
D
V
V
D
E
S
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K
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W
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P
D
-
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D
D
D
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R
I
F
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S
E
K
T
G
K
N
-
V
N
E
I
-
W
R
--------
E
V
G
R
Q
N
I
K
T
F
------------
S
E
W
F
-----
P
S
Y
--
F
--
A
G
R
R
------
L
V
-----
N
F
L
---
M
M
M
D
---
E
-
V
H
L
Q
-
L
T
K
M
I
K
-
G
-
A
T
----
P
P
R
L
I
A
------
K
P
V
A
---------------------------------------------------
K
-------
D
A
-
I
E
M
----
E
Y
V
S
----
K
R
------------------------------------------
K
--------
M
Y
D
Y
F
L
G
L
I
E
G
S
S
K
F
F
K
E
---------------------------------------------------------------
E
-
I
S
V
E
-
E
V
E
R
G
E
K
D
G
F
S
R
L
K
-------
V
R
I
K
F
K
N
P
V
F
E
-
Y
-
K
K
N
---------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
44.19
34%
-337
- C6 -
2ZJI
1
BACE1_HUMAN
A:
[340-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
C
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
43.77
34%
-299
- C6 -
3BRA
-
BACE1_HUMAN
A:
[336-364]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
42.45
11%
-153
- C2 -
1M4I
3
AAC2_MYCTU
A:
[1-181]
---------------------------------------------------------------
M
H
T
---------------------
Q
-
V
H
T
A
R
L
V
H
---------------
T
A
D
L
D
S
E
T
R
Q
D
I
R
Q
M
V
T
G
A
F
A
G
D
F
T
E
T
D
-
W
E
--------
H
T
L
G
G
M
H
A
L
I
------------
W
H
H
G
-----
A
I
I
--
A
--
H
A
A
V
I
-
Q
R
R
L
I
Y
-----
R
G
N
---
A
L
R
C
---
G
-
Y
V
E
G
-
V
A
V
R
A
D
W
R
-
G
Q
----
R
L
V
S
A
L
------
L
D
A
V
--------
E
-
Q
V
------
M
R
G
A
Y
Q
L
G
A
L
S
S
----
S
-
A
R
--------
A
R
R
L
-
Y
-------
A
S
-
R
G
W
----
L
P
W
H
----
G
P
T
S
V
L
A
---------------------------------
P
T
G
P
V
--------
R
T
P
D
D
D
G
---
T
V
F
V
L
P
I
D
---------
I
S
-
L
D
T
----------
S
A
E
L
-
M
C
D
--------------------------------------------------------------
W
R
A
G
---------
D
V
W
------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
41.59
34%
-253
- C6 -
2VNN
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
41.33
34%
-234
- C6 -
2VIJ
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
40.79
34%
-240
- C6 -
2WF0
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
40.73
34%
-240
- C6 -
2VJ9
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
40.66
34%
-240
- C6 -
2XFK
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
40.64
34%
-241
- C6 -
2WF4
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
40.56
34%
-258
* C6 *
2VIE
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
40.23
34%
-254
- C6 -
2VJ6
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
39.87
34%
-241
- C6 -
2VNM
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
39.81
34%
-235
- C6 -
2WF2
1
BACE1_HUMAN
A:
[321-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
K
F
A
--
I
--
S
Q
S
S
T
-
G
T
V
M
G
A
-----
V
I
M
---
E
G
F
Y
---
V
-
V
F
D
R
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------