@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04260: (2016-06-07 )
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGHLVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVIATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQTLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQKLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSVFEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK
Atome Classification :
(20 SA)
------------.........10........20----...--...----..------30.------.--.-.....40........50----.........------60----..-.......70-..--......80........90.----.......100.......110.......120.----...---...130.......140.......150..-.....160.......170.......-----180.---------..---------....190.......200.......210.......220----..-----------......230-----.------------------.------......240.......250..-......260.......270-.......280.......290.......300.-------.-------.....310.......320.......330.....-..-340.......-350.......360..-.....370..---.---.-----.----..----380.......390.......400.......410..----.....420....--...430.......440..--.....450.......460.......470.......480.......490.......500.......510.......520.......530..-.....540........550.---......560.......570.......580.......----590.....-.-.-600----..--.----.-----.....610.......620.......630..-..-----...640.....------------------..650.......660-.......670.----......680.......690.......700.......710.......720.-....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MSK
T
V
V
L
AEKPSV
G
R
D
L
A
R
V
L
----
K
C
H
--KKG----NG------YLE------G--D-
Q
Y
I
V
T
WALG
H
L
V
T
LAD-----PEGY
G
K
E
F
Q
------S-----WR-LEDLPIIPE-P
L
--
K
L
V
V
I
KKTG
K
Q
F
N
A
V
K
S
Q
L
----
T
R
K
DV
N
Q
I
V
I
ATDAGRE
G
E
L
V
A
R
W
I
I
E
KA
N
V
----
R
K
P
---
I
K
R
L
W
I
S
SV
T
D
K
A
I
K
E
G
F
Q
K
L
RSG
K
E
Y
E
-
N
L
Y
H
S
A
V
ARAEA
D
W
I
V
GINA
T
R
A
L
T
-----
T
KFN---------
A
Q
---------LSCGRVQT
P
T
L
A
M
I
AKREADIQAFTPV
P
Y
Y
G
I
R
A
AV-----DG-----------
M
T
L
T
WQDK------K------------------S------KQTRTF
N
Q
D
V
T
S
R
L
L
K
NL-QG-
K
Q
A
V
V
A
E
L
K
K
T
A
K
K
SF
A
P
A
-
L
Y
D
L
T
E
L
Q
R
D
A
H
K
RFGF
S
A
K
E
T
L
S
V
L
Q
K
L
Y
E
-------Q-------HK
L
V
TYPRTDSR
F
L
SSD
I
V
P
T
L
K
D
R
LEGMEV
K
P
-
Y
A
-
Q
Y
V
S
Q
I
K
KRG-IKSHKGYVNDAKVSD-H
H
A
IIPTEE
P
---
L
---
V
-----
L
----SS----LS
D
K
E
R
K
L
Y
D
L
I
A
K
R
F
L
A
V
L
M
P
AFE
Y
E
E
T
K
V
I
A
E
I----GG
E
T
FTAKGKTV--QSQG
W
K
A
V
Y
DMAEEDDEQ--EDDRDQTL
P
A
LQKG
D
T
L
A
V
R
T
L
TETSGQTKPPARFNEG
T
L
L
S
AMEN
P
S
A
F
MQGEEK
G
L
V
K
T
L
GETGGL
G
T
V
A
T
R
A
D
I
I
E
K
L
F
N
S
F
L
I
EKK-G
Q
D
I
F
I
-TSK
G
K
Q
L
L
Q
L
V
P
E
---
D
LKSPAL
T
A
E
W
E
Q
K
L
S
A
I
A
AGKLK
S
A
V
F
I
K
D
M
K
A
Y
A
----
H
Q
T
V
K
E
I
K
-N-S-S------QT--F----R-----HDNITGTA
C
P
E
CG
K
M
M
L
K
V
NGKRG
T
M
L
V
C
Q-DR-----ECGSRKTIARK------------------TNARCP
N
C
H
K
R
M
E
LR-GQGEG
Q
T
F
A
C
V----CG
H
R
E
K
L
S
V
F
E
K
RKNK
D
K
A
R
A
T
K
R
D
V
S
S
Y
M
K
KQNKDEP
I
N
N
A
L
A
E
Q
L
K
K
L-GLDK
25
PsiBlast_CBE
97.46
33%
0
- C- -
2O19
2
TOP3_ECOLI
B:
[3-636]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
APEK
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
ILGRN
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
VTPAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
97.46
33%
0
- C- -
2O54
2
TOP3_ECOLI
B:
[3-636]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
APEK
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
ILGRN
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
VTPAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
97.46
33%
0
- C- -
2O59
3
TOP3_ECOLI
B:
[3-639]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C
-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
PAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
97.46
33%
0
- C- -
2O5C
2
TOP3_ECOLI
B:
[3-636]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
APEK
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
ILGRN
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
VTPAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
97.46
33%
0
- C- -
2O5E
2
TOP3_ECOLI
B:
[3-636]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
APEK
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
ILGRN
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
VTPAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
97.46
33%
0
- C- -
2O5E
3
TOP3_ECOLI
A:
[3-634]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C
-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
VTPAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
97.46
33%
0
- C- -
2O5C
3
TOP3_ECOLI
A:
[3-634]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C
-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
PAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
97.46
33%
0
- C- -
2O54
3
TOP3_ECOLI
A:
[3-637]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C
-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
PAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
97.46
33%
0
- C- -
2O19
3
TOP3_ECOLI
A:
[3-637]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C
-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
PAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
96.33
33%
0
- C- -
2O59
2
TOP3_ECOLI
A:
[3-641]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C
-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
PAD
E
R
-----------
F
T
A
I
W
Q
P
S
--------------------------CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
-----
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
76.39
34%
-89
- C1 -
1I7D
3
TOP3_ECOLI
A:
[1-620]
--------------
M
R
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
----
P
K
P
H
-
R
K
G
----
D
G
------
F
I
E
------
C
--
G
N
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
----
H
E
A
--
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
-----
I
L
G
R
N
A
GYQ----
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
-----
V
T
PAD
E
R
------
F
T
A
I
W
Q
P
S
EACEPY
Q
------------------
D
------
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
F
P
R
S
D
C
R
Y
L
P
E
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H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
--
A
P
-
D
L
L
P
Q
-
P
V
V
D
-
P
D
I
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
----------
I
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
-----
E
N
D
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
--
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
-----------------
P
-----
V
R
Q
F
R
G
I
V
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.21
33%
-93
- C1 -
1D6M
-
TOP3_ECOLI
A:
[3-609]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C
-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G---------------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
PAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.12
33%
-93
- C1 -
1I7D
3
TOP3_ECOLI
A:
[3-609]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
P---
K
P
H
--
R
K
G
----
D
G
------
F
I
E
C
-----
G
--
N
-
G
Q
V
V
T
W
C
I
G
H
L
L
E
Q
A
Q
-----
P
D
A
Y
D
S
R
Y
A
------
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
-
K
W
--
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
------
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
Q
Q
---
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
-
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
PAD
E
R
-----------
F
T
A
I
W
Q
P
S
------
E
------------------
A
CEPYQD
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
-
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
I
T
F
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
H
A
-
P
D
-
L
L
P
Q
P
V
V
D
P
D
-
I
R
N
R
--
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
---
A
-----
I
-----
N
----
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
E
N
--
D
---
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
-
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
----
Y
Q
L
I
D
Q
A
K
-
R
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
63.00
26%
-75
- C1 -
4CGY
1
TOP3A_HUMAN
A:
[34-640]
------------
V
R
K
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
----
S
N
G
R
M
R
R
R
----
E
G
LSKF
N
K
I
Y
E
F
D
Y
H
L
Y
G
Q
N
V
-
T
M
V
M
T
S
V
S
G
H
L
L
A
H
D
F
-----
Q
M
Q
F
----
R
------
K
-----
W
Q
--
S
C
N
P
L
V
L
F
-
E
A
--
E
I
E
K
--
Y
C
P
E
N
F
V
D
I
K
K
T
L
E
R
E
T
R
Q
C
--
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
K
A
V
KP-
N
L
Q
---
V
L
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
P
D
Q
---
R
V
S
D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
-----
L
R
L
Q
R
I
F
PEVLAE
Q
L
---------
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
I
K
V
T
H
-----
D
H
KD
G
I
-------
V
E
F
N
W
K
-----------------------------------
R
H
R
L
F
N
H
T
A
C
L
V
L
Y
Q
L
C
-
V
E
D
P
M
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
P
Q
-
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
T
-------
Q
--------
G
Y
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
N
--
L
T
V
L
V
E
Q
Q
T
P
D
P
R
W
G
-
A
F
A
Q
S
--
I
L
E
-
R
G
G
P
T
P
R
N
G
N
K
S
D
Q
A
-
H
P
P
I
H
P
T
K
Y
T
---
N
---------------
N
----
L
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
----
A
Q
E
R
F
V
A
H
G
L
M
I
--
L
A
R
N
Y
L
D
V
Y
P
Y
D
H
W
---------
S
D
K
I
L
P
V
Y
E
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
E
T
S
P
P
K
L
L
T
E
A
D
L
I
A
L
M
E
-------------------
K
H
G
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
T
P
D
K
R
F
L
P
-
G
H
L
G
M
G
L
V
E
G
Y
D
S
MGY
E
M
S
K
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
K
A
K
-
K
L
D
E
A
------
L
A
Q
Y
F
GNGT---------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
62.24
25%
-71
- C1 -
4RUL
8
TOP1_ECOLI
A:
[4-709]
-------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
----
G
S
--------------------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
--------------K
D
E
R
G
A
L
-----
V
N
R
M
G
V
D
P
W
H
N
W
-
E
A
--
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
----
E
K
A
--
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D---
D
A
R
---
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
---
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
-----
K
K
I
A
---------
R
G
---------
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
-----
T
T
PSG
E
A
------
L
A
L
Q
V
T
H
Q
------
N
------------------
D
------
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
-
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
-------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
-----
K
Y
------
L
P
-
E
S
P
N
Q
Y
A
S
K
---
Q
E
A
-
H
E
A
I
R
P
S
D
V
N
---
V
MAE
S
-----
L
----
K
D
----
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
D
G
W
T
K
V
M
P
A
L
R
K
G
-------
D
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-------------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
F
Y
A
-
E
K
M
G
E
I
V
T
D
R
L
E
E
NFR
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
----
T
Q
Q
L
D
K
A
E
-
K
D
P
E
E
------
G
G
--
M
R
P
--
N
-----
Q
M
V
L
T
S
I
D
C
P
T
C
G
R
K
M
G
I
R
T
A
S
T
G
V
F
L
G
C
S
G
Y
A
LPPKE
R
C
K
T
T
I
N
L
V
P
E
NEVLNVLEGED
A
E
T
N
A
L
R
A
K
R
R
C
P
K
C
G
T
A
M
D
S
Y
L
I
D
P
K
R
K
L
H
V
C
G
NNPT
C
D
G
Y
E
--------------------------------------------------
50
Fugue
60.45
26%
-64
* C1 *
4CGY
1
TOP3A_HUMAN
A:
[22-640]
FS
R
A
A
M
E
M
A
L
RG
V
R
K
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
S
N
GR
M
R
R
--
R
E
G
LSKF
N
K
------
I
Y
E
------
F
--
D
-
Y
H
L
Y
G
Q
N
V
T
M
V
M
T
S
V
S
GHL
L
-
A
H
D
F
Q
M
Q
F
R
------
K
-----
W
Q
-
S
C
N
P
L
V
L
F
E
-
A
E
--
I
E
K
Y
C
P
E
N
F
V
D
I
K
K
T
L
E
R
E
----
T
R
Q
-
C
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
K
A
----
V
K
P
N
L
Q
V
L
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
P
D
--
Q
-
R
V
S
D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
-----
L
R
L
Q
---------
R
I
F
PEVLAEQL
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
I
K
V
T
H
-----
D
H
KD
G
I
-------
V
E
F
N
W
K
R
H
-----------------------------------
R
L
F
N
H
T
A
C
L
V
L
Y
Q
L
C
V
E
D
-
P
M
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
P
Q
-
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
T
-------
Q
-------
G
Y
-
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
--
N
L
T
V
L
V
E
Q
Q
T
P
D
P
R
W
G
-
A
F
A
Q
S
I
L
E
R
G
G
P
T
P
R
N
G
N
K
S
D
Q
A
----
H
P
P
I
H
P
T
K
Y
T
------------------
N
N
----
L
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
----
A
Q
E
R
F
V
A
H
G
L
M
I
--
L
A
R
N
Y
L
D
V
Y
P
Y
---------
D
H
W
S
D
K
I
L
P
V
Y
E
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
E
T
S
P
P
K
L
L
T
E
A
D
L
I
A
L
M
E
K
H
-------------------
G
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
T
-
P
D
K
R
F
L
P
G
H
L
G
M
G
L
V
E
G
Y
D
S
MGY
E
M
S
K
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
K
A
K
K
L
D
E
A
L
A
Q
Y
F
G
N
G
T
31
HHSearch
60.28
26%
-77
- C1 -
1MW9
9
TOP1_ECOLI
X:
[2-580]
-------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
----
G
S
--------------------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
---------------------ERGAL
V
N
R
M
G
V
D
P
W
H
N
W
-
E
A
--
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
----
E
K
A
--
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D---
D
A
R
---
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
--
E
L
N
I
-
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
-----
K
K
I
A
---------
R
G
---------
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
-----
T
T
PSGEA------
L
A
L
Q
V
T
H
Q
------
N
------------------
D
------
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
-
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
-------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
-----
K
Y
------
L
P
-
E
S
P
N
Q
Y
A
---------
R
E
A
I
R
P
S
D
V
N
---
V
MAE
S
-----
L
----
K
D
----
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
D
G
W
T
K
V
M
P
A
L
-----------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-------------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
F
Y
A
-
E
K
M
G
E
I
V
T
D
R
L
E
E
NFR
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
----
T
Q
Q
L
D
K
A
E
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
59.83
25%
-59
- C1 -
5D5H
8
TOP1_MYCTU
A:
[19-674]
-------------
G
R
R
L
V
I
V
E
S
P
T
K
A
R
K
L
A
S
Y
L
----
G
S
--------------------------------
G
Y
I
V
E
S
S
R
G
H
I
R
D
L
P
R
AASDV
P
A
K
Y
K
S
-
Q
-------
P
-----
W
A
---
R
L
G
V
N
V
D
A
D
F
E
P
L
Y
I
I
S
P
E
K
R
S
T
V
S
E
L
R
G
L
L
----
K
D
V
--
D
E
L
Y
L
A
T
D
G
D
R
E
G
E
A
I
A
W
H
L
L
E
T
L
K
P
----
R
I
P
---
V
K
R
M
V
F
H
E
I
T
E
P
A
I
R
A
A
A
E
H
P
R
D
L
D
I
---
D
L
V
D
A
Q
E
T
R
R
I
L
D
R
L
Y
G
Y
E
V
S
P
V
L
W
-----
K
K
V
A
---------
P
K
---------
L
S
A
G
R
V
Q
S
V
A
T
R
I
I
V
A
R
E
R
D
R
M
A
F
R
S
A
A
Y
W
D
I
L
A
K
L
-----
D
A
SVSDPDAAPP
T
F
S
A
R
L
T
A
V
------
A
GRRVATGRDFDSLGTLRK
G
------
D
E
V
I
V
L
D
E
G
S
A
T
A
L
A
A
G
L
-
D
G
-
T
Q
L
T
V
A
S
A
E
E
K
P
Y
A
R
R
P
Y
P
-
P
F
M
T
S
T
L
Q
Q
E
A
S
R
K
L
R
F
S
A
E
R
T
M
S
I
A
Q
R
L
Y
E
-------
N
--------
G
Y
I
T
Y
M
R
T
D
S
T
T
L
S
E
S
A
I
N
A
A
R
T
Q
A
R
Q
L
Y
G
D
-----
E
Y
V
---
A
P
A
--
P
R
Q
Y
T
R
K
V
K
N
-
A
Q
E
A
-
H
E
A
I
R
P
A
G
E
T
FAT
P
---
D
A
V
R
R
E
L
----
D
G
----
P
N
I
D
D
F
R
L
Y
E
L
I
W
Q
R
T
V
A
S
Q
M
A
D
A
R
G
M
T
L
S
L
R
I
T
G
M
SGH
Q
E
V
V
F
S
A
T
G
R
T
L
--
T
F
P
G
F
L
K
A
Y
V
E
T
V
D
E
L
V
G
G
E
A
D
D
A
E
R
R
L
P
H
L
T
P
G
Q
R
L
D
I
V
E
L
T
P
D
G
H
A
T
N
P
P
A
R
Y
T
E
A
S
L
V
K
A
L
E
-------------------
E
L
G
I
G
R
P
S
T
Y
S
S
I
I
K
T
I
Q
D
R
G
Y
V
H
K
K
-
G
S
A
L
V
P
-
S
W
V
A
F
A
V
T
G
L
L
E
Q
HFG
R
L
V
D
Y
D
F
T
A
A
M
E
D
E
L
D
E
I
A
A
G
N
E
R
R
T
N
W
L
N
N
F
Y
F
G
G
----
D
H
G
V
P
D
S
V
A
R
-
S
G
G
L
K
K
L
V
G
I
N
--
L
----
E
GID
A
R
E
V
N
S
I
K
L
F
D
D
T
H
G
R
P
I
Y
V
R
V
G
K
N
G
P
Y
L
E
R
L
V
A
G
------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.44
26%
-71
- C1 -
2GAJ
-
TOP1_THEMA
A:
[7-586]
---------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
---------------------------------
G
--
N
-
E
Y
E
V
F
A
S
M
G
H
I
I
D
L
P
K
-----
S
K
-
F
G
V
D
L
E
----------------
K
D
F
----
E
-
P
---
E
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
-
L
----
A
K
K
--
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
----
L
G
R
---
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
---
V
K
N
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
-----
R
N
F
K
---------
S
N
---------
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
N
F
-----
D
G
-----------
L
T
---
A
E
I
------
D
------------------
V
------
K
E
K
K
F
F
D
A
E
T
----
L
K
E
I
-
Q
S
-
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
KD
G
H
-------
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
----
Y
A
K
E
E
A
R
N
L
I
T
E
V
-
F
G
E
E
Y
V
G
----------------------A
H
E
A
I
R
P
T
N
V
F
---
M
---
T
-----
P
----
E
E
A
G
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
----
K
D
G
K
Y
R
F
K
G
T
V
L
-------
K
K
I
F
D
G
Y
E
K
V
W
K
T
--
E
--
R
N
T
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
-------------------
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
-
R
G
Y
L
Y
P
-
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
YS
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
--------
Y
E
S
F
S
S
V
F
-
D
-
R
-
N
------
D
R
--
I
----
V
-----
V
D
F
P
T
N
Q
K
C
-
S
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
---------
E
C
G
K
T
R
S
V
-----------------------------------------------------------------------------------------------------------
30
HHSearch
56.00
28%
-80
- C- -
2GAI
-
TOP1_THEMA
A:
[7-588]
---------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
----
G
N
--------------------------------
E
Y
E
V
F
A
S
M
G
H
I
I
D
L
P
K
-----
S
K
-
F
G
----------------
V
D
---
L
E
K
D
F
E
P
-
E
----
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
L
A
----
K
-
K
--
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
----
L
G
R
---
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
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A
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K
N
P
R
E
I
D
M
---
K
K
V
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A
Q
L
A
R
R
I
L
D
R
I
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G
Y
S
L
S
P
V
L
W
-----
R
N
F
K
---------
S
N
---------
L
S
A
G
R
V
Q
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A
T
L
K
L
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C
D
R
E
R
E
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L
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F
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K
K
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H
R
I
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N
F
-----
D
G
-----------
L
T
A
E
I
D
V
K
---------------------------------
E
K
K
F
F
D
A
E
T
L
K
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D
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K
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A
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-
P
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A
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-------
G
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G
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-----
E
Y
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--------
G
-------------
A
-
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A
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V
F
---
M
---
T
-----
P
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----
L
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K
L
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L
I
W
K
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A
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Q
M
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T
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L
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----
K
D
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V
L
K
K
I
F
D
G
Y
E
K
V
W
K
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-----------
N
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M
E
-------------------
R
L
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A
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L
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D
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K
K
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L
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F
Y
E
S
F
----
S
S
V
F
D
R
N
D
-
R
--------------
I
----
V
-----
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
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L
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F
G
K
Y
G
F
Y
L
K
C
E
---------
C
G
K
T
R
S
V
K
N
---------------------------------------------------------------------------------------------------------