@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04330: (2016-06-07 )
MSEFKQQELFWSNMFDAEDRLIAFPSFHMSDSALEHDALNTSNSIHTSLRSDVSLRIMTMAIIPMAVYLVLLVGIKCLLHKYTGEESIIVGVPTFEDETDEDLRLDQIMLLKQNINENSTFKSIFNEFKHTLNDAILHQDVPFDKMVGPLNLNYNSNHLPMIPAIVSLDQIHLIHFKETAASDTLFQFDIKNDAIHLKVTYNEQAYDRQYMMQVIEHLNRLFSIILFQPDITISQLNILTDTEINTFKDYNQTAAEYPREKTIHQLFEEQANRTPDQVAVVYEENQLTYQELNEKANQIARTLQSEGVHPDQPVGIMAERSLEMIVGLFGILKAGGAYVPIDPTYPEERIRYILEDSDTKLLLVQHHLREKVPFTGKVLDMEDPQTFSEDGSNLESISGPNQLAYVIYTSGSTGKPKGVMVEHRSVINRLVWMQENYPLDERDAILQKTAITFDVSVWELFWWSIVGSKVVLLPNGGEKNPELILDTIEQKGVSTLHFVPAMLHAFLESMEQTPSGKLKRKLASLRYVFASGEALTPKHVDGFQRIITPVSHAQIINLYGPTEATIDVSYFECEADKRYNSVPIGKPISNIQLYILQAGYMQPVGVAGELCIAGDGLARGYLNRPELTAEKFVKNPFSAGERMYRTGDLARWLPDGNIEYLGRIDHQVKIRGYRIETGEVEAALFHIPSIQESIVLAQEINEEISLCAYYTANDTLTAGELREHLSRQLPSYMIPAYFIQLKRMPLTLNGKIDRRALPSPRENLTGMDYTAPRTELEKILAATWESVLGLERVGVSDHFFELGGDSIKSIQVSSRLYQAGYKFEIKHLFKYPTISELVPYVEPVTRVAEQGEIKGPALLTPIQHWFFDQRYPDLHHYNQAVMLYWKEGLNVPMLREVMRKIVEHHDALRMVYVPAKHGYEARNREIDEGDLFSLEVFSLLEENNVAQTIETLSNEIQQSIQLAEGPLIKLGLFQCQDGDHLLIVAHHLVIDGVSWRILIEDIAAAYEQLLNGEAIQLPKKTDSYLLWAEQLKRYAESPEFEMKNQYWFQHEHIPLPKLPKDNEQEIGLAEDRETIIVQWTAEETERLLKNAHRAYTTEMNDLLLTGLGIAIHRWTGHEDILIHLEGHGRESIIPDLDISRTVGWFTSQYPVFLPIKADHDISQRIKTVKEHLRKIPQKGIGYGIIKYLSDHREDREFTGQPEISFNFLGQFDQDLQNGSIEVSPYSSGKIASDKHPLTYALDINGMISNGRLSLAISYCGKQYHKETMETCADLLKSSLRQVIEHCTAQDQVQLTPSDISLKEISIDELDQFVQQAQHLGEIENIYPLTPMQKGMLFHSLIDSASGAYFEQAAFDLKGLLDIEAFMMSLSQLAKRYDILRTQFYTEWKEQPLQIVLRHKPIETVVEDIRDMNVDQRSEFIAAFARKDKERGFNLIRDALMRVSILRTDEEKARLIWSFHHILMDGWCLPLITKEVFETYYAIIERRQPKRDAVTPYRQYIEWLDEQDHEQAAVYWRDYLDDYEGQTVLLKEPFSDQARGYQKQKLACRLGKQLTEEIKRAASQHHVTVNTWMQTAWGLLLQRYNGTQDVVFGTVVSGRPADIPGIESMVGLFINTIPVRVCAQPEMTVAQVLKMNQEHALASQPYDTFPLYEIQAQTEQKQQLINHIMVFENYPVEKQMEHMKRDHDVLDISDFHLEEHTHYDFNFIVMPAEDMEMHFVYNANVYDQATVERIQAHFMEIIKQMVNDTAVHVQELDILSEDERSLLIEKFNDTATEYPKEKTIYQLFEEQAARTPEQIAIVFEDQKLTYRQLNEQANQLARTLRAKGVRSDRTAAIISDHSIELVVGILAVLKAGGAYVPIDPDYPEQRIQYILNDSKTEIVLTQSHLQQRLAHEGTIVLLDDENSYHKERSNLERISNIKDLAYVIYTSGSTGKPKGVLIEHQGLTNYIWWADRVYVKGEKTTFPLYSSIAFDLTVTSIFTPLISGNAIIVYGDKDRTTLLSSIIEDSRVDIIKLTPAHLQLLKEMNISPECTIRKMIVGGDNLSTRLAQNISEQFQDQIEIFNEYGPTETVVGCMIYLYDPKKDRQESVPIGTAAANMNIYLLDTGMKPVPIGVPGEMYISGAGVARGYLNRPDLTAEKFVEHPFAAGERMYKTGDAARWMPDGHMEYLGRIDHQVKVRGYRIELGEVEAALLLVESVKEAVVIAVEEEGSNQLCAYVTGDESLKTLQLKQQLQNKLPAYMIPAYFVQIEEMPLTANGKIDREALPAPDGNMLAGTEYAAPRTLIEKQLAEIWKEVLAHSELGIKDNFFDVGGHSLKVLQLVDQINKVMGIKLHYHVVYEAPTIETMAHAIQAAALPSKTENVFVKLNQNGSIPVFCFPPLIGYGLVYNEMANRLDGDCVVYAADFTEDPSYKKPIIDRFAESMIDIQEQGPFVLLGYSSGSNLAFEVAKALEQRGRTVSDVIMLDSQITTSVTHLSEKEVEEIIHLNLDIIPVYYRELLTIPSIKEKIRGYLAYHNQLINSGTINANIHHLLCDDMTERGWTHSTAHNYKEYELKGDHVTIFDPQYIEENMSTIRSIMKCIEEQQLGELVPHEQLSYMSRTKSDRT
Atome Classification :
(25 SA)
.........10........20........30........40........50........60.-.......70........80........90........--100----........110.......120.......130.......140.......150.......160.......170...-------------------.--------...180.......190-........200.......210.......220.......230.......240......-.250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......---370...---....380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500........510.......520.......530.......540.......550.......560.......570---....----....580.......590....-..-.600...--.....610.......620.......630......-.640.......650.......660.......670.......680.......690...-...-------.-700....-------....710...--..--..720.......730.......740.......750.......760.--..-....770.......780.......790.......800.......810......-.820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350....-----..1360.......1370......1380......1390......1400..-....1410......1420......1430......1440......1450......1460......1470......1480......1490......1500...------...1510......1520.-.....1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650-......-----1660....----..1670-----------......1680--------......1690.-..-...1700......--1710......--1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840.......1850......1860......1870......1880-----......1890-..-...---...1900.----.....1910.......1920-.......1930......1940......1950.......1960......1970......1980......1990..---..-.---.--.--2000..--....2010......2020-..----....2030--.--.....2040......2050......2060......2070..-...-..----2080......2090...-...2100......2110......2120......2130......2140...-..-.2150......2160......2170......2180......2190......2200....-..--2210.--.-....2220.....--..-----..2230--........2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......-2370-......2380......2390......2400..--------....2410-----..-....2420......2430......2440......2450......2460......2470......---2480-.----.....2490-----....-....2500.--------...----..-2510---....--.-----..2520......2530....---..-----2540........2550......2560......2570......2580......2590......2600......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
E
F
K
Q
Q
E
L
F
W
S
NMFDAED
R
L
I
AFPSFHMSDSALEHDALNTSN
S
I
H
T
S
L
RSD
V
S
L
R
I
M
T
M
A
I
-
I
P
M
A
V
Y
L
V
L
L
V
G
I
K
C
L
L
H
K
YTGEE
S
I
I
V
GVPTFEDET--DE-----D
L
R
L
D
Q
I
M
L
L
K
QNINENS
T
F
K
S
I
F
N
E
F
K
H
T
L
N
D
A
I
LHQDV
P
F
D
KMV
G
P
L
N
LNYNSNHLPMI
P
A
IVSL
D
Q
I
H
L
I
H
-------------------
F
--------KETAASD
T
L
F
Q
F
DI-K-N
D
A
I
H
L
K
V
T
YNE
Q
A
Y
D
R
Q
Y
M
M
Q
V
I
E
H
L
N
R
L
F
S
I
I
L
FQPD
I
T
I
S
Q
L
N
I
L
TDTEIN
T
F
K
-
D
Y
N
Q
T
A
A
EYP
R
E
K
T
I
H
Q
L
F
E
E
Q
ANRTPD
Q
V
A
V
V
Y
EENQ
L
T
Y
Q
E
L
N
E
K
A
N
Q
I
A
R
T
L
Q
SEGVHPDQP
V
G
I
M
A
E
R
S
L
E
M
I
V
G
L
F
G
I
L
KAGG
A
Y
VPIDPTY
P
E
E
R
I
R
Y
ILEDSD
T
K
L
L
L
V
Q
H
H
L
R
---EKVPFT---
G
K
VLDMEDPQTFSEDGSNLESISGP
N
Q
L
A
Y
V
I
Y
TSGSTGKPK
G
V
M
V
E
H
R
S
V
I
N
R
L
V
W
MQENYPL
D
E
R
D
A
I
L
Q
K
T
A
I
T
F
D
V
S
V
W
E
L
F
W
W
S
IVG
S
K
V
V
L
LPNGGEK
N
P
E
L
I
L
D
T
I
E
QKGV
S
T
L
H
F
V
P
A
-
M
L
H
A
F
L
E
S
M
E
QTP
S
G
K
L
K
R
K
L
A
S
L
R
Y
V
FASGEALT
P
K
H
V
D
G
F
Q
R
I
ITPVS
H
A
Q
I
I
N
L
YGPT
E
A
T
I
D
V
S
Y
F
----
E
CEA----DKRYNSVPIGKPIS
N
I
Q
L
Y
I
L
-QA-GY-MQPV--GVAG
E
L
C
IAGD
G
L
A
R
GYLNRPEL
T
A
E
K
F
VKNPFS-AGE
R
M
YRTG
D
L
A
RWLPDGN
I
E
Y
L
GRID
H
Q
V
K
I
R
G
Y
R
IETGE
V
E
A
A
L
F
HIP
S
I
Q
E
S
I
V
-
L
A
Q
-------
E
-
I
-
N
E
E
I
S
-------
L
C
A
Y
YTANDT--L
T
--
A
G
E
L
R
E
H
L
S
R
QL
P
S
Y
M
I
P
A
Y
F
I
Q
L
KRM
P
L
TLNGKIDRRALPSPREN--LT-GMDYTA
P
R
T
E
L
E
K
I
L
A
A
T
W
E
S
V
L
G
L
E
RVGVS
D
H
F
F
E
LGGD
S
I
K
S
I
Q
V
S
S
R
L
Y
Q-AG
Y
K
F
E
I
K
H
L
FKYP
T
I
S
E
L
V
P
Y
V
E
P
V
T
R
V
A
EQGEIKG
P
A
L
L
T
P
I
Q
H
W
F
F
DQRYP
D
L
H
HY
N
Q
A
V
M
L
Y
W
K
EGLN
V
P
M
L
R
E
V
M
R
K
I
V
E
H
HDA
L
R
M
V
Y
VPAKHGYEARNREIDEGD
L
F
S
L
E
V
F
S
L
L
E
EN
N
V
A
Q
T
I
E
T
L
S
N
E
I
Q
Q
S
I
QLAEG
P
L
I
K
L
G
L
F
QCQDG
D
H
L
L
I
V
A
H
H
L
VIDGV
S
W
R
I
L
I
E
D
I
A
A
A
Y
E
Q
LLNGE
A
I
QLPKKTD
S
Y
L
L
W
A
E
Q
L
K
R
Y
AESPEFEMKN
Q
Y
W
F
QHEHIPLPKLPKDNEQEIGLAEDR
E
T
I
I
V
Q
W
T
A
E
E
T
E
R
L
L
K
N
A
H
R
A
Y
T
T
E
M
N
D
L
L
L
T
GL
G
I
A
I
H
RWTGH
E
D
I
L
I
H
L
EGHGRESIIPDLDISRTVGWFTSQY
P
V
F
L
P
I
KADH
D
I
S
Q
R
I
K
T
V
K
E
H
L
R
KI
P
Q
KGI
G
Y
G
I
I
K
Y
L
S
D
HREDREFTGQP
E
I
S
F
N
F
L
G
Q
F
D
Q
D
LQNG
S
I
E
V
SPYSSGKIASDKH
P
L
T
Y
A
L
DIN
G
M
I
SN
G
R
L
S
L
A
I
S
Y
C
G
K
Q
Y
H
K
E
T
M
E
T
C
A
D
L
L
K
S
S
L
R
Q
V
I
E
HCTAQ
D
Q
V
Q
LTPSDI
S
L
KEI
S
I
D
E
L
D
Q
F
V
Q
Q
A
Q
HLG
E
I
ENIYPLT
P
M
Q
K
G
M
L
F
H
S
L
I
D
SASG
A
Y
F
E
Q
A
A
F
D
L
K
-----
G
L
L
D
I
-
E
A
F
M
M
S
L
S
Q
L
A
K
R
Y
D
I
L
R
T
Q
F
Y
T
E
W
KEQP
L
Q
I
V
L
RHK
P
I
E
T
V
V
-
E
D
I
R
DM
N
V
D
Q
R
S
E
F
I
A
A
F
A
R
K
D
K
E
R
G
F
N
L
I
R
D
A
L
M
R
V
S
ILRT
D
E
E
K
A
R
L
I
W
S
F
H
H
I
L
MDGW
C
L
P
L
I
T
K
E
V
F
E
T
Y
Y
A
I
I
E
RRQPKRDA
V
T
P
Y
R
Q
Y
I
E
WLDEQ------
D
H
E
Q
A
A
V
Y
W
R
D
Y
L
D
DYEG-
Q
T
V
L
L
KEPF
S
D
Q
A
R
G
Y
Q
K
Q
K
L
A
C
R
L
G
K
Q
L
T
E
E
I
K
R
A
A
SQH
H
V
T
V
N
T
W
M
Q
T
A
W
G
L
L
L
Q
RYNGTQ
D
V
V
F
G
T
VVSGRPADIP
G
I
E
S
M
V
G
L
F
I
NT
I
P
V
R
V
CAQP
E
M
T
V
A
Q
V
L
K
MN
Q
E
HALASQPYDTF
P
L
Y
E
I
-QA
Q
T
E
Q
-----
K
Q
Q
L
I
N
H
I
----
M
V
FENY-----------
P
V
E
K
Q
M
E
H
M
K--------RDHDVLD
I
S
D
F-HL-EEHTHY
D
F
N
F
I
V
M--PAED
M
E
M
H
F
V
--YNANVY
D
Q
A
T
V
E
R
I
Q
A
H
F
M
E
I
I
K
Q
M
V
N
D
T
A
V
H
V
Q
E
L
D
ILSE
D
E
R
S
L
L
I
E
K
FN
D
T
A
TEYPK
E
K
T
I
Y
Q
L
F
E
E
Q
AARTP
E
Q
I
A
I
V
F
EDQK
L
T
Y
R
Q
L
N
E
Q
A
N
Q
L
A
R
T
L
R
AKGVRSDR
T
A
A
I
ISDH-
S
I
E
L
V
V
G
I
L
A
V
L
KAGG
A
Y
VPIDPDY
P
E
Q
R
I
Q
Y
I
LNDSK
T
E
I
V
L
-----
T
Q
S
H
L
Q
Q
R
---
L
A-HE
G
---
T
I
V
L
L
DDE----N
S
Y
H
K
E
R
S
-
N
L
E
R
I
SNIK
D
--
L
A
Y
V
I
Y
TSGSTGKPK
G
V
L
I
EHQGLT
N
Y
I
W
-
W
A
D
R
V
Y
VKGEKT
T
F
P
L
Y
S
S
I
A
F
D
L
T
V
T
S
I
F
T
P
L
ISG
N
A
I
-
I
V
YG---DK-
D
---
R
--
T
--
T
L
L
S
S
I
--
I
EDSR
V
D
I
I
K
L
T
P
A
H
L
Q
L
-
L
K
----EMNISPE
C
--
T
--
I
R
K
M
I
VGGD
N
L
S
T
R
L
A
Q
N
I
S
E
Q
F
Q
D
Q
I
E
I
F
N
EYGP
T
E
-
T
V
V
-
G
C
M
-
I
Y
----
L
YDPKKDRQESVPI
G
T
A
-AA
N
M
N
I
Y
L
LDTGMKPVPIGVPG
E
M
Y
I
SGAGVARGYLNRPDL
T
A
E
K
F
VEHP-FA-AGE
R
M
YKTGDAARWMPD
G
H
M
E
Y
L
G
RID
H
Q
V
K
V
R
G
Y
R
I
ELG
E
V
E
A
A
L
L
L
V
E
S
VKE
A
V
V
I
A
-
V
E--EEGSN--
Q
-
L
C
A
Y
V---TGDES--
L
K
-----
T
L
Q
L
----
K
Q
Q
L
Q
NKL
P
A
Y
M
I
P
A
Y
F
V
Q
I
EEMPLTANGKIDREALPAPDG
N
M
LAGTEYA
A
P
R
T
L
I
E
K
Q
L
A
E
I
W
K
E
V
L
A
HSELGIKDN
F
F
DVGGH
S
L
K
V
L
Q
L
V
D
Q
I
N
K
VM
G
I
K
L
H
Y
H
V
V
Y
EAP
T
I
E
T
M
A
H
A
I
Q
A
AALPSKT
E
N
V
F
V
K
L-NQNG-
S
I
P
V
F
CFP
P
L
I
G
Y
G
L
V
Y
N
E
M
A
N
RLDG
D
C
V
V
Y
A--------ADFTEDPS-----YK-
K
P
I
I
D
R
F
A
E
S
M
I
D
I
QEQG
P
F
V
L
L
G
YSSGS
N
L
A
F
E
V
A
K
A
L
E
QRGRT
V
S
D
V
I
M
LDSQI
T
T
S
V
THL
S
---
E
K
E
V
-
E
----
E
I
I
HLNL-------
D
I
I
P
-
V
Y
Y
R
E
LLTI--------
P
S
I
----
K
E
-
K
I
R
----
G
Y
L
A
--
Y
-----
H
N
Q
LINSGTINA
N
I
H
H
L
LCD---
D
M
-----
T
E--RGWTHSTAHN
Y
K
E
Y
E
LKG
D
H
V
T
IF
D
P
Q
Y
I
E
E
N
M
S
T
I
R
S
I
M
K
C
I
E
E
Q
Q
L
G
E
LV
P
H
E
Q
L
S
Y
M
S
RTKSDRT
1
PsiBlast_PDB
59.77
35%
-101
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[8-1259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
-----
G
S
L
N
I
-
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
E
-
I
D
L
T
H
L
T
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
Q
------
D
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
-
Q
T
T
-
F
A
E
Q
R
K
K
Q
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
E
I
K
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
-
Q
S
Q
A
D
Q
-----
P
-
K
L
I
D
H
I
----
I
V
F
E
N
Y
-----------
P
L
Q
-
D
A
K
N
E
E
--------
S
S
E
N
G
F
D
M
V
D
V
-
H
V
-
F
E
K
S
N
Y
D
L
N
L
M
A
S
--
P
G
D
E
M
L
I
K
L
A
--
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
A
H
E
T
K
P
L
T
Y
-
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
-
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
-----
T
H
Q
E
M
K
E
Q
AAE
L
P
-
Y
T
G
---
T
T
L
F
I
D
D
Q
----
T
R
F
E
E
Q
A
S
-
D
P
A
T
A
I
D
P
N
D
--
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
-
H
V
D
Y
M
A
F
-
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
-
I
I
A
D
---
E
H
-
T
LL-
D
--
T
--
E
R
L
T
D
L
--
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
L
-
L
T
----
D
A
G
E
D
W
M
K
--
G
--
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
-
A
L
R
I
M
G
P
G
K
L
I
N
C
Y
G
P
T
E
-
G
T
V
-
F
A
T
-
A
H
----
V
V
H
D
L
P
D
S
I
S
S
L
P
I
G
K
P
-
I
S
N
A
S
V
Y
I
L
N
E
Q
S
Q
L
Q
P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
-
F
K
-
P
G
E
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
--
E
S
G
D
A
--
S
-
I
N
A
Y
L
---
V
N
R
T
Q
--
L
S
-----
A
E
D
V
----
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
Q
L
A
-
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
-
S
D
G
L
Q
D
V
T
I
-
M
-
N
Q
D
Q
-
E
Q
I
I
F
A
F
P
P
V
L
G
Y
G
L
M
Y
Q
N
L
S
S
R
L
P
S
-
Y
K
L
C
A
--------
F
D
F
I
E
E
E
D
-----
R
-----
L
D
R
Y
A
D
L
I
Q
K
L
Q
P
E
G
P
L
T
L
F
G
Y
S
A
G
C
S
L
A
F
E
A
A
K
K
L
E
E
Q
G
R
I
V
Q
R
I
I
M
V
D
S
Y
K
K
Q
G
V
S
---T
V
-
E
S
D
V
-
E
----
A
L
M
N
V
N
R
-----------------------------
E
A
V
KHG
L
K
Q
-
K
T
H
----
A
F
Y
S
--
Y
-----
Y
V
N
-----
Q
V
K
A
D
I
D
L
L
T
S
G
A
D
F
D
I
-----
P
E
WL
A
S
W
E
E
A
T
T
G
V
Y
R
M
K
R
G
F
G
T
H
A
E
M
L
Q
G
E
T
L
D
R
N
------------------------------------
55
HHSearch
59.02
35%
-104
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[7-1272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
-----
G
S
L
N
I
-
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
E
-
I
D
L
T
H
L
T
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
Q
------
D
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
-
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
G
Y
E
P
K
E
L
L
F
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P
S
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A
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T
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A
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Q
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A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
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V
V
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R
P
A
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I
K
G
V
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M
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G
L
F
I
N
V
V
P
R
R
V
K
L
S
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G
I
T
F
N
G
L
L
K
R
L
Q
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Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
-
Q
S
Q
A
D
------
Q
P
K
L
I
D
H
I
----
I
V
F
E
N
Y
-----------
P
L
Q
D
A
K
N
E
E
---------
S
S
E
N
G
F
D
M
V
D
V
-
H
V
-
F
E
K
S
N
Y
D
L
N
L
M
A
S
--
P
G
D
E
M
L
I
K
L
A
--
Y
N
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V
F
D
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A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
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R
E
F
L
L
T
G
L
N
P
P
A
Q
A
-
H
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
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G
Q
T
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Y
R
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L
D
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A
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R
L
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A
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K
G
S
V
V
A
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R
-
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I
L
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L
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A
G
A
A
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P
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L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
-----
T
H
Q
E
M
K
E
Q
---
A
A
-
E
L
P
YT
G
T
T
L
F
I
D
D
Q
----
T
R
F
E
E
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A
S
-
D
P
A
T
A
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D
P
N
D
--
P
A
Y
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G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
-
H
V
-
D
Y
M
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
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M
L
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A
A
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L
-
I
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A
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---
E
H
-
T
---
L
LD
T
--
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L
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L
--
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
L
-
L
T
----
D
A
G
E
D
W
M
K
--
G
--
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
A
L
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M
-
G
P
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K
L
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N
C
Y
G
P
T
E
-
G
T
V
-
F
A
T
-
A
H
----
V
V
H
D
L
P
D
S
I
S
S
L
P
I
G
K
P
-
I
S
N
A
S
V
Y
I
L
N
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Q
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Q
L
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P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
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K
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A
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L
T
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K
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L
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D
Q
V
K
I
R
G
H
R
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L
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Q
L
Q
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Y
P
G
V
K
D
A
V
V
V
A
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D
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H
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S
G
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A
--
S
-
I
N
A
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---
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N
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Q
--
L
S
-----
A
E
D
V
----
K
A
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L
K
K
Q
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A
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V
P
Q
T
F
T
F
L
D
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L
P
L
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T
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V
N
K
R
L
L
P
K
P
D
Q
D
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L
-
A
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W
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P
R
N
E
M
E
E
T
I
A
Q
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D
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F
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A
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K
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A
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I
A
G
I
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A
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L
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G
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L
--
Q
D
V
T
I
M
-
N
Q
D
Q
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Q
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G
Y
G
L
M
Y
Q
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L
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L
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S
Y
K
L
C
A
--------
F
D
F
I
--
E
-------
E
-
E
D
R
L
D
R
Y
A
D
L
I
Q
K
L
Q
P
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P
L
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L
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G
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A
G
C
S
L
A
F
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A
A
K
K
L
E
E
Q
G
R
I
V
Q
R
I
I
M
V
D
S
Y
K
K
Q
G
V
S
--------
T
V
-
E
----
S
D
V
E
A
L
M
--------
N
V
N
-
R
-------
E
--------
A
V
K
----
H
G
L
K
Q
K
T
---
H
A
F
Y
S
-
Y
-----
Y
V
N
-----
Q
V
K
A
D
I
D
L
L
T
S
G
---
A
D
F
D
I
P
E
W
L
--
A
S
W
E
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A
T
T
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V
Y
R
M
K
R
G
F
G
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A
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L
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G
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T
L
D
R
N
A
E
I
L
L
E
F
L
N
T
Q
T
V
-----------------------
60
HHSearch
48.62
30%
-100
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[187-1041]
---
W
Q
R
D
A
A
F
W
A
E
Q
R
R
Q
L
P
P
P
A
S
L
S
P
A
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L
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----
A
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L
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L
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--
S
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G
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--
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L
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Y
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L
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I
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V
Q
A
Q
T
H
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--------
L
--------
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A
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-
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---
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---
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N
L
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A
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L
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-
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---
A
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A
L
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A
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----
G
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L
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G
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A
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----
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T
-
G
-
G
D
A
R
Q
-------
L
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L
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S
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L
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--
T
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A
L
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A
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L
L
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L
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L
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A
L
P
L
P
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L
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--
A
--
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A
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A
P
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A
G
S
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T
I
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A
A
A
F
S
S
L
L
G
C
D
V
Q
D
A
D
A
D
F
F
A
L
G
G
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L
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L
A
A
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L
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V
A
S
T
V
A
K
L
A
T
I
I
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
47.27
24%
-116
- C1 -
4ZXH
3
?
A:
[10-1318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
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P
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C
S
A
Y
N
M
V
V
A
F
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-----
V
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L
G
N
K
P
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A
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M
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-
S
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A
R
H
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----
A
S
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L
T
Q
L
V
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Q
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---
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----
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L
-----------
G
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L
L
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M
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---
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A
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A
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A
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A
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L
A
A
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K
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L
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A
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L
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L
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A
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L
----
P
L
-
D
A
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Y
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---
D
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Y
A
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N
V
V
A
V
A
Q
T
I
D
Q
M
Y
P
---------------------------
62
HHSearch
46.70
46%
-97
- C1 -
5ES8
1
LGRA_BREPA
A:
[201-768]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
K
T
F
H
Q
L
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G
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L
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K
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----
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N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
-
D
E
A
L
A
-
L
Q
P
I
--
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
--
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
-
L
A
K
-------
E
Q
A
-
D
G
R
K
Y
-------
L
V
G
Y
Y
V
A
P
E
E
--
I
P
--
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
------------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
45.86
45%
-95
- C1 -
5ES8
1
LGRA_BREPA
B:
[197-760]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
---
E
K
A
N
G
A
---
C
D
I
I
D
V
H
D
P
D
S
Y
S
E
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
-
A
A
E
Q
F
M
Q
M
D
N
Q
-----------
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
E
R
N
G
T
Y
K
---------
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
----
E
V
------
D
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
-
L
A
-
L
Q
P
I
--
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
-
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
-
L
A
K
-------
E
Q
A
-
D
G
R
K
Y
-------
L
V
G
Y
Y
V
A
P
E
E
--
I
P
--
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
Q
A
D
AE
L
L
---
D
Y
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
45.58
45%
-95
- C1 -
5ES8
1
LGRA_BREPA
A:
[197-760]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
---
E
K
A
N
G
A
---
C
D
I
I
D
V
H
D
P
D
S
Y
S
E
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
-
A
A
E
Q
F
M
Q
M
D
N
Q
-----------
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
E
R
N
G
T
Y
K
---------
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
----
E
V
------
D
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
-
L
A
-
L
Q
P
I
--
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
-
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
-
L
A
K
-------
E
Q
A
-
D
G
R
K
Y
-------
L
V
G
Y
Y
V
A
P
E
E
--
I
P
--
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
------------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
45.39
26%
-114
- C1 -
4ZXH
3
?
A:
[12-1166]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
QSL
G
N
K
P
I
-
E
I
----
L
E
A
V
M
H
D
Y
P
L
L
R
V
S
M
P
A
--
N
D
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
I
F
S
D
A
R
H
I
E
A
S
D
L
T
Q
L
V
----
E
Q
D
T
K
Q
P
F
D
L
T
Q
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
L
V
A
E
S
-----
D
A
V
N
G
I
-
E
F
V
Q
Y
A
D
K
Q
Q
S
SVID
D
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
-
R
P
A
V
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
R
--
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
K
-----
R
D
G
S
I
N
P
L
AQ
I
G
M
F
W
E
R
L
G
GMDEFKELLL
P
I
Q
T
P
A
T
L
V
G
--------
Q
D
---
L
T
L
G
S
F
-
P
V
R
Q
Q
E
G
Q
L
D
I
T
L
E
M
G
--
G
E
Y
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
A
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N
M
V
Q
L
L
Q
A
V
L
S
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M
V
A
H
P
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K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
Q
F
E
A
L
R
G
K
A
T
D
Y
-
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
-
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
-----
T
Q
T
E
L
M
D
G
---
L
---
N
V
---
S
V
P
R
L
D
I
N
----
Q
A
G
V
V
A
L
E
-
Q
V
R
E
T
L
A
F
G
D
--
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
Q
V
T
T
E
T
Q
L
L
A
I
-
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
-
H
V
C
P
R
E
V
S
Q
-
D
---
G
--
I
--
Q
L
V
D
Y
L
--
N
A
K
S
-
I
N
V
L
Q
A
T
P
A
T
W
K
M
-
L
L
----
D
S
E
W
S
G
N
A
--
G
--
L
T
A
L
-
C
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
K
V
G
C
---
L
W
N
V
Y
G
P
T
E
-
T
T
V
W
S
S
A
-
A
R
----
I
T
D
A
K
Y
-----
I
D
L
G
E
P
-
L
A
N
T
Q
L
Y
V
L
D
E
Q
Q
R
L
V
P
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
L
P
-
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
L
--
V
K
--
T
T
G
D
N
D
Q
K
-
L
V
A
Y
V
---
T
G
Q
E
---
L
D
-----
I
A
G
L
----
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
--
I
F
E
Q
S
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
K
--
E
I
K
P
S
I
V
I
E
L
-
R
R
G
T
Y
E
Q
P
L
W
L
F
H
P
I
G
G
S
T
F
C
Y
M
E
L
S
R
H
L
N
P
N
R
T
L
R
A
I
Q
S
PGLIE
A
D
A
A
E
V
A
I
-----
E
E
-
M
A
T
L
--
Y
I
A
E
M
Q
K
M
Q
P
Q
G
P
Y
F
L
G
G
W
C
F
G
G
A
I
A
Y
E
I
S
R
Q
L
R
Q
M
G
Q
Q
V
T
G
I
V
M
I
D
T
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
44.90
45%
-105
- C1 -
5ES9
1
LGRA_BREPA
A:
[197-760]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
---
E
K
A
N
G
A
---
C
D
I
I
D
V
H
D
P
D
S
Y
S
E
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
----
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
-
A
A
E
Q
F
M
Q
M
D
N
Q
-----------
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
E
R
N
G
T
Y
K
---------
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
----
E
V
------
D
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
-
L
A
-
L
Q
P
I
--
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
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L
T
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E
K
F
I
V
H
P
-
Q
-
T
G
E
R
M
Y
R
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D
R
A
R
F
L
P
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G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
-
L
A
K
-------
E
Q
A
-
D
G
R
K
Y
-------
L
V
G
Y
Y
V
A
P
E
E
--
I
P
--
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
Q
A
D
A--------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
44.88
28%
-115
- C1 -
4ZXH
2
?
A:
[195-1048]
---
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
A
V
----
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
--
R
S
LRNAL
G
Q
F
V
N
T
I
A
-
I
H
M
D
I
D
A
D
Q
T
L
R
Q
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T
Q
Q
V
Q
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L
R
Q
S
L
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Q
K
I
A
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S
R
V
V
E
A
V
S
P
K
R
D
G
S
I
N
P
L
A
Q
I
G
M
F
W
E
R
L
G
G
M
D
EFKELLLPIQTP
A
T
L
V
G
QD
L
T
L
G
S
F
P
V
R
Q
Q
E
G
Q
L
D
I
T
L
E
M
G
G
E
Y
-
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
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E
N
M
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Q
L
L
Q
A
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L
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A
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P
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E
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A
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D
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F
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A
L
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-
Y
A
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L
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A
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I
L
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Q
I
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E
R
G
D
N
H
A
L
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--
H
T
V
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Y
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L
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I
A
G
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A
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Y
L
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A
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Q
G
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G
L
M
L
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L
L
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A
A
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L
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A
A
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A
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Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
T
Q
T
E
L
M
---
D
G
L
N
V
S
---
V
P
R
L
D
I
N
Q
A
G
V
--
V
A
L
E
Q
V
R
E
T
L
A
F
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
K
S
I
N
V
L
Q
A
T
P
A
-
T
W
K
M
L
L
D
S
E
W
---------
S
G
N
A
G
L
T
A
L
C
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
K
-----
V
G
C
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
A
A
----
R
I
T
-------
D
A
K
Y
I
D
L
G
E
P
L
A
N
T
Q
L
Y
V
L
-
D
E
Q
Q
R
-
L
V
P
P
--
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
L
P
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
-
L
V
K
-------
T
-
T
G
D
N
D
Q
K
-------
L
V
A
Y
V
T
G
Q
E
---
L
D
--
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
I
F
E
--
Q
S
--
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
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Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
44.76
31%
-98
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[196-1060]
----
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
K
-----
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
EI
K
G
VEHMV
G
L
F
I
N
V
V
P
-
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
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Q
S
L
Q
S
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P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
Q
------
P
K
L
I
D
H
I
I
V
F
E
N
Y
P
L
Q
D
AKNEESSENGFDMV
D
V
H
--
V
--------
F
E
K
S
N
Y
D
L
N
L
M
A
S
--
P
-
G
D
E
M
L
I
K
L
A
Y
N
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N
V
F
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A
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L
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Q
L
L
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-
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W
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A
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N
A
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A
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L
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Y
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N
R
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A
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A
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K
G
S
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V
A
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L
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A
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I
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Y
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L
A
D
S
A
A
A
C
L
L
T
H
Q
E
M
K
---
E
Q
A
A
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L
PYT
G
T
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L
F
I
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D
Q
T
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F
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G
T
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N
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A
N
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G
L
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V
-
D
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M
A
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L
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V
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N
Y
A
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D
A
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A
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L
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A
A
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A
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L
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L
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L
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L
Q
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N
V
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V
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A
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A
-
L
F
N
L
L
T
D
A
G
E
--------
D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
A
L
R
I
M
---
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
----
V
V
H
D
L---
P
D
S
I
S
S
L
P
I
G
K
P
I
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N
A
S
V
Y
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L
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N
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Q
S
Q
-
L
Q
P
F
--
G
A
V
G
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L
C
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S
G
M
G
V
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Y
V
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A
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L
T
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E
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P
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P
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T
L
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R
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A
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P
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A
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R
I
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D
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L
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L
Q
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V
V
-
V
A
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-------
R
-
H
E
S
G
D
A
S
-------
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N
A
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L
V
N
R
T
Q
--
L
S
--
A
E
D
V
K
A
H
L
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K
Q
L
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A
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Q
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D
D
F
F
A
L
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G
H
A
L
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A
M
T
A
A
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I
K
K
E
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L
P
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L
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P
T
I
A
G
I
S
A
Y
L
K
N
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
44.72
26%
-115
- C1 -
4ZXI
5
?
A:
[12-1166]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
QSL
G
N
K
P
I
-
E
I
----
L
E
A
V
M
H
D
Y
P
L
L
R
V
S
M
P
A
--
N
D
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
I
F
S
D
A
R
H
I
E
A
S
D
L
T
Q
L
V
----
E
Q
D
T
K
Q
P
F
D
L
T
Q
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
L
V
A
E
S
-----
D
A
V
N
G
I
-
E
F
V
Q
Y
A
D
K
Q
Q
S
SVID
D
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
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P
-
R
P
A
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Q
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H
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V
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L
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N
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A
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V
A
G
R
L
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R
--
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
K
-----
R
D
G
S
I
N
P
L
AQ
I
G
M
F
W
E
R
L
GGMDEFKELLL
P
I
Q
T
P
A
T
L
V
G
--------
Q
D
---
L
T
L
G
S
F
-
P
V
R
Q
Q
E
G
Q
L
D
I
T
L
E
M
G
--
G
E
Y
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
Q
F
E
A
L
R
G
K
A
T
D
Y
-
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
-
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
-----
T
Q
T
E
L
M
D
G
---
L
---
N
V
---
S
V
P
R
L
D
I
N
----
Q
A
G
V
V
A
L
E
-
Q
V
R
E
T
L
A
F
G
D
--
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
Q
V
T
T
E
T
Q
L
L
A
I
-
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
-
H
V
C
P
R
E
V
S
Q
-
D
---
G
--
I
--
Q
L
V
D
Y
L
--
N
A
K
S
-
I
N
V
L
Q
A
T
P
A
T
W
K
M
-
L
L
----
D
S
E
W
S
G
N
A
--
G
--
L
T
A
L
-
C
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
K
V
G
C
---
L
W
N
V
Y
G
P
T
E
-
T
T
V
W
S
S
A
-
A
R
----
I
T
D
A
K
Y
-----
I
D
L
G
E
P
-
L
A
N
T
Q
L
Y
V
L
D
E
Q
Q
R
L
V
P
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
L
P
-
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
L
--
V
K
--
T
T
G
D
N
D
Q
K
-
L
V
A
Y
V
---
T
G
Q
E
---
L
D
-----
I
A
G
L
----
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
--
I
F
E
Q
S
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
K
--
E
I
K
P
S
I
V
I
E
L
-
R
R
G
T
Y
E
Q
P
L
W
L
F
H
P
I
G
G
S
T
F
C
Y
M
E
L
S
R
H
L
N
P
N
R
T
L
R
A
I
Q
S
PGLIE
A
D
A
A
E
V
A
I
-----
E
E
-
M
A
T
L
--
Y
I
A
E
M
Q
K
M
Q
P
Q
G
P
Y
F
L
G
G
W
C
F
G
G
A
I
A
Y
E
I
S
R
Q
L
R
Q
M
G
Q
Q
V
T
G
I
V
M
I
D
T
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
44.60
42%
-120
- C1 -
4D56
5
?
A:
[29-516]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
-
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
-----
T
Q
T
Q
W
S
N
L
---
I
S
D
Y
Q
G
---
Q
V
I
C
L
D
S
Q
W
A
K
I
A
S
Y
S
Q
E
---
N
L
V
N
T
V
N
P
E
N
--
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
-
L
A
I
A
Q
Y
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
-
I
L
R
T
---
E
E
-
M
---
I
--
S
--
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
A
Y
W
H
L
-
L
V
N
E
L
V
K
S
K
I
A
L
P
D
--
S
--
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
-
G
T
I
-
A
V
S
-
L
C
RLSQ
L
T
E
S
Q
R
N
R
T
E
-
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
L
K
T
V
P
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
-
F
S
-
P
S
E
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
-
R
----------
R
-
L
V
A
Y
L
V
P
H
S
T
E
E
N
--
L
------
T
V
T
L
----
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
43.84
45%
-105
- C1 -
1AMU
4
GRSA_ANEMI
A:
[29-530]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
K
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
L
I
H
N
I
Q
F
N
---
G
Q
V
E
I
F
E
E
D
T
I
K
I
R
E
G
T
N
L
H
V
P
S
K
S
T
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
Y
V
V
H
L
D
P
E
------------
R
I
L
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
K
V
T
------
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
----
V
A
T
K
----
E
T
I
G
H
S
V
P
I
G
A
P
I
Q
N
T
Q
I
Y
I
V
-
D
E
-
N
L
Q
L
K
S
V
--
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
-
P
G
E
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
-------
D
-
H
-
Q
E
Q
P
Y
-------
L
C
A
Y
F
V
S
E
K
H
--
I
P
--
L
E
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
--
D
--
L
T
F------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
43.82
42%
-118
- C1 -
4D57
5
?
A:
[29-516]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
-
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
-----
T
Q
T
Q
W
S
N
L
---
I
S
D
Y
Q
G
---
Q
V
I
C
L
D
S
Q
W
A
K
I
A
S
Y
S
Q
E
---
N
L
V
N
T
V
N
P
E
N
--
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
-
L
A
I
A
Q
Y
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
-
I
L
R
T
---
E
E
-
M
---
I
--
S
--
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
A
Y
W
H
L
-
L
V
N
E
L
V
K
S
K
I
A
L
P
D
--
S
--
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
-
G
T
I
-
A
V
S
-
L
C
RLSQ
L
T
E
S
Q
R
N
R
T
E
-
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
L
K
T
V
P
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
-
F
S
-
P
S
E
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
-
R
----------
R
-
L
V
A
Y
L
V
P
H
S
T
E
E
N
--
L
------
T
V
T
L
----
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
42.96
45%
-105
- C1 -
1AMU
4
GRSA_ANEMI
B:
[29-530]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
K
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
HLI
H
N
-
Q
F
N
---
G
Q
V
E
I
F
E
E
D
T
I
K
I
R
E
G
T
N
L
H
V
P
S
K
S
T
D
L
A
Y
V
I
Y
T
-----
N
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
Y
V
V
H
L
D
P
E
------------
R
I
L
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
K
V
T
------
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
----
V
A
T
K
----
E
T
I
G
H
S
V
P
I
G
A
P
I
Q
N
T
Q
I
Y
I
V
-
D
E
-
N
L
Q
L
K
S
V
--
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
-
P
G
E
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
-------
D
-
H
-
Q
E
Q
P
Y
-------
L
C
A
Y
F
V
S
E
K
H
--
I
P
--
L
E
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
--
D
--
L
T
F------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
42.72
42%
-117
- C1 -
4D4I
4
?
A:
[29-515]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
-
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
-----
T
Q
T
Q
W
S
N
L
---
I
S
D
Y
Q
G
---
Q
V
I
C
L
D
S
Q
W
A
K
I
A
S
Y
S
Q
E
---
N
L
V
N
T
V
N
P
E
N
--
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
-
L
A
I
A
Q
Y
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
-
I
L
R
T
---
E
E
-
M
---
I
--
S
--
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
A
Y
W
H
L
-
L
V
N
E
L
V
K
S
K
I
A
L
P
D
--
S
--
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
-
G
T
I
-
A
V
S
-
L
C
RLSQ
L
T
E
S
Q
R
N
R
T
E
-
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
L
K
T
V
P
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
-
F
S
-
P
S
E
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
-
R
----------
R
-
L
V
A
Y
L
V
P
H
S
T
E
E
N
--
L
------
T
V
T
L
----
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
42.56
45%
-107
- C1 -
5ES5
1
LGRA_BREPA
A:
[197-683]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
---
E
K
A
N
G
A
---
C
D
I
I
D
V
H
D
P
D
S
Y
S
E
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
-
A
A
E
Q
F
M
Q
M
D
N
Q
-----------
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
E
R
N
G
T
Y
K
---------
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
----
E
V
------
D
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
-
L
A
-
L
Q
P
I
--
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
-
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
-
L
A
K
-------
E
Q
A
-
D
G
R
K
Y
-------
L
V
G
Y
Y
V
A
P
E
E
--
I
P
--
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
42.10
42%
-117
- C1 -
4D4G
4
?
A:
[29-514]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
-
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
-----
T
Q
T
Q
W
S
N
L
---
I
S
D
Y
Q
G
---
Q
V
I
C
L
D
S
Q
W
A
K
I
A
S
Y
S
Q
E
---
N
L
V
N
T
V
N
P
E
N
--
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
-
L
A
I
A
Q
Y
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
-
I
L
R
T
---
E
E
-
M
---
I
--
S
--
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
A
Y
W
H
L
-
L
V
N
E
L
V
K
S
K
I
A
L
P
D
--
S
--
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
-
G
T
I
-
A
V
S
-
L
C
RLSQ
L
T
E
S
Q
R
N
R
T
E
-
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
L
K
T
V
P
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
-
F
S
-
P
S
E
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
-
R
----------
R
-
L
V
A
Y
L
V
P
H
S
T
E
E
N
--
L
------
T
V
T
L
----
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
41.94
37%
-100
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[382-1013]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
-
H
-
G
D
-
L
S
I
E
I
L
A
N
K
Q
R
Y
D
E
P
T
L
I
Q
H
A
E
R
L
K
M
L
I
A
Q
F
A
A
D
P
A
L
L
C
G
D
V
D
I
M
L
P
G
E
Y
A
Q
L
A
-
Q
L
N
A
T
Q
V
E
I
P
-
E
T
T
L
S
A
L
V
A
E
Q
A
A
K
T
P
D
A
P
A
L
A
D
A
R
Y
L
F
S
Y
R
E
M
R
E
Q
V
V
A
L
A
N
L
L
R
E
R
G
V
K
P
G
D
S
V
A
V
A
L
P
R
S
V
F
L
T
L
A
L
H
A
I
V
E
A
G
A
A
W
L
P
L
D
T
G
Y
P
D
D
R
L
K
M
M
L
E
D
A
R
P
S
L
L
I
T
T
D
D
Q
L
---
P
R
F
S
D
V
---
P
N
L
T
S
L
C
Y
N
A
P
L
T
P
Q
G
S
A
P
L
Q
L
S
Q
P
H
H
T
A
Y
I
I
F
T
S
G
S
T
G
R
P
K
G
V
M
V
G
Q
T
A
I
V
N
R
L
L
W
M
Q
N
H
Y
P
L
T
G
E
D
V
V
A
Q
K
T
P
C
S
F
D
V
S
V
W
E
F
F
W
P
F
I
A
G
A
K
L
V
M
A
E
P
E
A
H
R
D
P
L
A
M
Q
Q
F
F
A
E
Y
G
V
T
T
T
H
F
V
P
S
-
M
L
A
A
F
V
A
S
L
--
T
P
Q
-
T
A
R
Q
S
C
A
T
L
K
Q
V
F
C
S
G
E
A
L
P
A
D
L
C
R
E
W
Q
Q
L
----
T
G
A
P
L
H
N
L
Y
G
P
T
E
A
A
V
D
V
S
W
Y
P
AFG
E
E
L
A
----
Q
V
R
G
S
S
V
P
I
G
Y
P
V
W
N
T
G
L
R
I
L
-
D
A
--
M
-
M
H
P
V
PP
G
V
A
G
D
L
Y
L
T
G
I
Q
L
A
Q
G
Y
L
G
R
P
D
L
T
A
S
R
F
I
A
D
P
F
A
-
P
G
E
R
M
Y
R
T
G
D
V
A
R
W
L
D
N
G
A
V
E
Y
L
G
R
S
D
D
Q
L
K
I
R
G
Q
R
I
E
L
G
E
I
D
R
V
M
Q
A
L
P
D
V
E
Q
A
V
T
-
H
A
C
-------
V
-
I
-
N
Q
A
A
A
TGGDA
R
Q
L
V
G
Y
L
V
S
Q
S
G
--
L
P
LD
T
S
A
L
Q
A
Q
L
R
E
T
L
P
P
H
M
V
P
V
V
L
L
Q
L
P
Q
L
P
L
S
A
N
G
K
L
D
R
K
A
L
P
L
P
-
E
L
--
K
A
-
Q
A
P
G
R
A
P
K
A
G
S
E
T
I
I
A
A
A
F
S
S
L
L
G
C
D
V
Q
D
A
D
A
D
F
F
A
L
G
G
H
S
L
L
A
M
K
L
A
A
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
33.26
31%
-100
- C1 -
3E7W
2
DLTA_BACSU
A:
[15-497]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
T
D
A
F
R
S
Q
G
Q
S
L
T
Y
Q
E
L
W
E
Q
S
D
R
A
A
A
A
I
Q
K
R
I
S
G
E
K
K
S
P
I
L
V
Y
G
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
E
S
S
G
A
E
L
L
I
-----
H
A
A
G
L
S
I
D
---
A
V
-
G
Q
----
Q
I
Q
T
V
S
A
E
----
E
L
L
E
N
E
G
G
-
S
V
S
Q
D
Q
W
V
K
E
HE
T
F
Y
I
I
Y
T
S
G
S
T
G
N
P
K
G
V
Q
I
S
A
A
N
L
Q
S
F
T
D
-
W
I
C
A
D
F
P
V
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
L
Y
P
C
L
Q
S
G
G
T
L
H
C
V
T
K
---
D
A
V
N
---
K
--
P
--
K
V
L
F
E
E
--
L
K
K
S
G
L
N
V
W
T
S
T
P
S
F
V
Q
M
C
L
M
----
D
P
G
F
S
Q
D
L
--
L
PH
A
D
T
F
M
F
C
G
E
V
L
P
V
S
V
A
K
A
L
L
E
R
F
-
P
K
A
K
I
F
N
T
Y
G
P
T
E
A
T
V
A
-
V
T
S
-
V
E
----
I
T
N
D
V
I
S
R
S
E
S
L
P
V
G
F
A
-
K
P
D
M
N
I
F
I
M
D
E
E
G
Q
P
L
P
E
G
E
K
G
E
I
V
I
A
G
P
S
V
S
R
G
Y
L
G
E
P
E
L
T
E
K
A
F
F
S
H
-----
E
G
Q
W
A
Y
R
T
G
D
A
G
-
F
I
Q
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
-
Y
Q
--
P
N
G
T
V
--
E
Y
L
I
A
A
I
---
V
P
E
E
H
EF
E
K
-----
E
F
Q
L
T
S
A
I
K
K
E
L
A
A
S
L
P
A
Y
M
I
P
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
33.08
32%
-110
- C1 -
3FCE
1
DLTA_BACCR
A:
[8-498]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
I
S
S
E
-
Y
P
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
S
ATAV
T
V
T
D
L
P
V
R
---
I
V
-
S
E
D
---
N
---
L
K
D
I
----
F
F
T
H
K
G
N
T
P
N
P
E
H
A
V
K
G
D
E
--
N
F
Y
I
I
Y
T
S
G
----
P
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
F
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
-
W
A
I
----
D
K
-
D
M
I
A
R
--
P
--
K
D
L
F
A
S
--
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
L
M
----
E
A
S
F
S
E
S
M
LP
N
--
M
K
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
K
L
I
E
R
F
P
-
K
A
T
I
M
N
T
Y
G
P
T
E
-
A
T
V
-
A
V
T
G
I
H
----
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
-
K
S
D
C
R
L
L
I
M
K
E
D
G
T
I
A
P
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
T
----
M
I
-
D
G
E
R
A
Y
K
T
G
D
A
G
-
Y
V
E
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
-
I
K
KG
E
K
Y
D
Y
--
L
-
L
A
V
V
V
---
P
G
E
H
S
--
F
E
K
E
F
K
L
T
S
A
I
----
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
32.75
32%
-107
- C1 -
3DHV
2
DLTA_BACCR
A:
[8-498]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
I
S
S
E
-
Y
P
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
S
ATAV
T
V
T
D
L
P
V
R
---
I
V
-
S
E
D
---
N
---
L
K
D
I
----
F
F
T
H
K
G
N
T
P
N
P
E
H
A
V
K
G
D
E
--
N
F
Y
I
I
Y
T
S
-----
P
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
F
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
-
W
A
I
----
D
K
-
D
M
I
A
R
--
P
--
K
D
L
F
A
S
--
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
L
M
----
E
A
S
F
S
E
S
M
LP
N
--
M
K
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
K
L
I
E
R
F
P
-
K
A
T
I
M
N
T
Y
G
P
T
E
-
A
T
V
-
A
V
T
G
I
H
----
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
-
K
S
D
C
R
L
L
I
M
K
E
D
G
T
I
A
P
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
T
----
M
I
-
D
G
E
R
A
Y
K
T
G
D
A
G
-
Y
V
E
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
-
I
K
KG
E
K
Y
D
Y
--
L
-
L
A
V
V
V
---
P
G
E
H
S
--
F
E
K
E
F
K
L
T
S
A
I
----
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
32.18
31%
-99
- C1 -
3E7X
1
DLTA_BACSU
A:
[15-497]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
T
D
A
F
R
S
Q
G
Q
S
L
T
Y
Q
E
L
W
E
Q
S
D
R
A
A
A
A
I
Q
K
R
I
S
G
E
K
K
S
P
I
L
V
Y
G
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
E
S
S
G
A
E
L
L
I
-----
H
A
A
G
L
S
I
D
---
A
V
-
G
Q
----
Q
I
Q
T
V
S
A
E
----
E
L
L
E
N
E
G
G
-
S
V
S
Q
D
Q
W
V
K
E
HE
T
F
Y
I
I
Y
T
S
G
S
T
G
N
P
K
G
V
Q
I
S
A
A
N
L
Q
S
F
T
D
-
W
I
C
A
D
F
P
V
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
L
Y
P
C
L
Q
S
G
G
T
L
H
C
V
T
K
---
D
A
V
N
---
K
--
P
--
K
V
L
F
E
E
--
L
K
K
S
G
L
N
V
W
T
S
T
P
S
F
V
Q
M
C
L
M
----
D
P
G
F
S
Q
D
L
--
L
PH
A
D
T
F
M
F
C
G
E
V
L
P
V
S
V
A
K
A
L
L
E
R
F
-
P
K
A
K
I
F
N
T
Y
G
P
T
E
A
T
V
A
-
V
T
S
-
V
E
----
I
T
N
D
V
I
S
R
S
E
S
L
P
V
G
F
A
-
K
P
D
M
N
I
F
I
M
D
E
E
G
Q
P
L
P
E
G
E
K
G
E
I
V
I
A
G
P
S
V
S
R
G
Y
L
G
E
P
E
L
T
E
K
A
F
F
S
H
-----
E
G
Q
W
A
Y
R
T
G
D
A
G
-
F
I
Q
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
-
Y
Q
--
P
N
G
T
V
--
E
Y
L
I
A
A
I
---
V
P
E
E
H
EF
E
K
-----
E
F
Q
L
T
S
A
I
K
K
E
L
A
A
S
L
P
A
Y
M
I
P
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
32.11
32%
-111
- C1 -
3FCC
1
DLTA_BACCR
A:
[8-498]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
I
S
S
E
-
Y
P
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
S
ATAV
T
V
T
D
L
P
V
R
---
I
V
-
S
E
D
---
N
---
L
K
D
I
----
F
F
T
H
K
G
N
T
P
N
P
E
H
A
V
K
G
D
E
--
N
F
Y
I
I
Y
T
S
G
----
P
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
F
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
-
W
A
I
----
D
K
-
D
M
I
A
R
--
P
--
K
D
L
F
A
S
--
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
L
M
----
E
A
S
F
S
E
S
M
LP
N
--
M
K
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
K
L
I
E
R
F
P
-
K
A
T
I
M
N
T
Y
G
P
T
E
-
A
T
V
-
A
V
T
G
I
H
----
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
-
K
S
D
C
R
L
L
I
M
K
E
D
G
T
I
A
P
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
T
----
M
I
-
D
G
E
R
A
Y
K
T
G
D
A
G
-
Y
V
E
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
-
I
K
K
G
E
K
Y
D
Y
--
L
-
L
A
V
V
V
---
P
G
E
H
S
--
F
E
K
E
F
K
L
T
S
A
I
----
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------