@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04340: (2016-06-07 )
MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQLKFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAGQVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLSVSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAKRELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGTSFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFLNACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARHFKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVKYKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEELAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSLKKSLKRLF
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110....---...120.......130.......140.......150.......160.......170----....------.-.-...180-..-..--...190.......200.......210....-...220.......230.......240.......250.-......260.......270.......280--..---......290.......300.......310.......320....-...330.......340.......350.......360.......370.......380.......390.......400.......410.......420....-...430.......440.......450.......460.......470.......-480.-.......490.......500.......510...--...--.520.......530.-......540.......550.......560.......570..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAHK
T
A
G
Q
A
M
T
E
L
L
E
Q
WGVDHVYGIPG
D
S
I
N
E
F
I
E
E
L
R
H
E
R
N
Q
L
K
F
I
Q
T
R
H
E
E
V
A
A
L
A
A
A
AE
A
K
L
T
G
K
I
G
V
C
L
SIAGP
G
A
V
H
L
L
N
G
L
YDAKADGA
P
V
L
A
I
A
G
QVSSGEV
G
R
D
Y
F
Q
E
---
I
K
L
E
Q
M
F
E
D
V
A
V
F
N
R
EVH
S
A
E
S
L
P
D
L
L
N
Q
A
I
R
T
A
YSKK
G
V
A
V
L
SVS
D
D
L
F
A
E
K
I
------KREP------V-Y-TS
P
V
Y
I
-EG-NL--EP
K
K
E
Q
L
V
T
C
A
Q
Y
I
NNAKK
P
I
I
L
AGQ
G
M
K
K
-
A
K
R
E
L
L
E
F
A
D
KAAA
P
I
V
V
T
LPAKGVVPDKH
P
H
F
L
GNL-GQIGT
K
P
A
Y
E
A
M
E
EC
D
L
L
I
M
LGTSFPYR---DY---LPDDT
P
A
I
QLDS
D
P
A
KIGKRYPVT
A
G
L
VCDSAL
G
L
R
E
L
T
E
Y
I
E
-
R
K
E
D
R
R
F
L
N
A
C
T
E
H
M
Q
H
W
W
N
E
I
EKDETEATTPL
K
P
Q
Q
V
V
A
R
L
Q
E
AAAD
D
A
V
L
S
V
DV
G
T
V
T
V
W
M
A
R
H
FKMNANQ
D
F
I
V
S
S
W
L
A
T
MGCGL
P
G
A
I
A
A
SLSEPE-
R
Q
A
I
A
V
CGDG
G
F
S
M
V
M
Q
DLPT
A
V
K
Y
KL
P
I
T
V
V
I
LNNENLG
M
I
E
Y
E
Q
Q
VKGNI
D
-
Y
V
-
T
-KLQNV
D
Y
A
A
F
A
E
S
CGAKG
I
K
VT
K
A
E
E
L
A
P
A
F
H
E
--
A
LH--SDQ
P
V
V
V
D
V
M
IGNEP-PLP
G
K
I
T
YGQAK
G
F
S
K
Y
M
L
K
N
F
FENQKFE
M
P
S
L
K
K
S
L
K
R
LF
12
PsiBlast_PDB
91.77
37%
-110
- C7 -
3EY9
6
POXB_ECOLI
A:
[3-568]
---
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
-
N
R
M
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
---
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
V
V
V
L
P
G
D
V
---
A
L
------
K
P
A
P
EGATMH
W
-
Y
-
H
A
P
Q
P
V
-----
V
--
T
P
E
E
E
E
L
R
K
L
A
Q
L
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
-
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
-
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
---
A
F
---
Y
P
T
D
A
K
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
-
E
K
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
P
S
E
K
A
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
-
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
A
M
E
M
K
A
G
G
Y
L
T
-
D
G
-
T
-
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
--
A
F
S
--
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
I
K
L
E
Q
A
K
G
F
S
L
Y
M
L
R
A
I
I
S
G
R
G
D
E
V
I
E
L
A
K
T
-----
34
PsiBlast_CBE
91.63
37%
-110
- C7 -
3EY9
6
POXB_ECOLI
B:
[3-568]
---
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
-
N
R
M
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
---
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
V
V
V
L
P
G
D
V
---
A
L
------
K
P
A
P
EGATMH
W
-
Y
-
H
A
P
Q
P
V
-----
V
--
T
P
E
E
E
E
L
R
K
L
A
Q
L
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
-
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
-
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
---
A
F
---
Y
P
T
D
A
K
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
-
E
K
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
P
S
E
K
A
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
-
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
A
M
E
M
K
A
G
G
Y
L
T
-
D
G
-
T
-
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
--
A
F
S
--
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
I
K
L
E
Q
A
K
G
F
S
L
Y
M
L
R
A
I
I
S
G
R
G
D
E
V
I
E
L
A
K
T
-----
58
HHSearch
91.60
37%
-118
- C7 -
3EYA
11
POXB_ECOLI
A:
[2-539]
--
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
-
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
---
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
V
V
V
L
P
G
D
V
A
L
K
P
A
-------
P
E
G
------
A
-
T
M
H
W
Y
H
A
P
-
Q
P
-
V
V
--
T
P
E
E
E
E
L
R
K
L
A
Q
L
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
-
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
-
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
---
A
F
---
Y
P
T
D
A
K
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
A
-
D
R
K
F
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
P
S
E
K
A
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
-
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
-------------
G
-
T
-
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
--
A
F
S
--
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
I
K
----------------------------------
1
PsiBlast_PDB
90.23
37%
-97
- C7 -
1POW
3
POXB_LACPL
A:
[5-545]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
13
PsiBlast_PDB
89.92
37%
-117
- C7 -
3EYA
11
POXB_ECOLI
A:
[3-539]
---
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
-
N
R
M
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
---
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
V
V
V
L
P
G
D
V
---
A
L
------
K
P
A
P
EGATM
H
W
-
Y
-
H
A
P
Q
P
V
-----
V
--
T
P
E
E
E
E
L
R
K
L
A
Q
L
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
-
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
-
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
---
A
F
---
Y
P
T
D
A
K
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
-
E
K
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
P
S
E
K
A
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
-
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
-------------
G
-
T
-
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
--
A
F
S
--
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
I
K
----------------------------------
43
PsiBlast_CBE
89.82
37%
-118
- C7 -
3EYA
1
POXB_ECOLI
D:
[3-533]
---
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
-
N
R
M
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
---
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
V
V
V
L
P
G
D
V
---
A
L
------
K
P
A
P
EGATMH
W
-
Y
-
H
A
P
Q
P
V
-----
V
--
T
P
E
E
E
E
L
R
K
L
A
Q
L
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
-
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
-
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
---
A
F
---
Y
P
T
D
A
K
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
-
E
K
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
P
S
E
K
A
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
-
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
-------------
G
-
T
-
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
--
A
F
S
--
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
----------------------------------------
21
PsiBlast_CBE
89.56
37%
-97
- C7 -
1POW
3
POXB_LACPL
B:
[5-545]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
LP
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
AK
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
6
PsiBlast_PDB
89.40
37%
-96
- C7 -
2EZ4
5
POXB_LACPL
A:
[13-553]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
67
HHSearch
89.02
38%
-99
* C7 *
4KGD
9
?
A:
[9-546]
-
T
N
I
L
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
-------
P
A
E
------
D
W
Y
-
A
S
A
N
S
Y
Q
T
P
L
L
P
--
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
F
I
G
-
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
--
A
K
A
I
A
Q
H
E
P
V
L
I
D
A
V
I
T
G
--------------------------------------------
7
PsiBlast_PDB
88.72
37%
-96
- C7 -
2EZ8
4
POXB_LACPL
A:
[13-553]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
45
PsiBlast_CBE
88.71
37%
-117
- C7 -
3EYA
7
POXB_ECOLI
B:
[3-535]
---
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
-
N
R
M
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
---
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
V
V
V
L
P
G
D
V
---
A
L
------
K
P
A
P
EGATMH
W
-
Y
-
H
A
P
Q
P
V
-----
V
--
T
P
E
E
E
E
L
R
K
L
A
Q
L
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
-
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
-
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
---
A
F
---
Y
P
T
D
A
K
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
-
E
K
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
P
S
E
K
A
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
-
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
------------
D
G
-
T
-
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
--
A
F
S
--
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
--------------------------------------
9
PsiBlast_PDB
88.63
37%
-95
- C7 -
2EZT
5
POXB_LACPL
A:
[13-553]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
35
PsiBlast_CBE
88.49
37%
-118
- C7 -
3EYA
41
POXB_ECOLI
L:
[3-535]
---
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
-
N
R
M
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
---
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
G
V
S
V
V
V
L
P
G
D
V
---
A
L
------
K
P
A
P
EGATMH
W
-
Y
-
H
A
P
Q
P
V
-----
V
--
T
P
E
E
E
E
L
R
K
L
A
Q
L
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
-
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
D
N
P
Y
D
V
G
M
T
-
G
L
I
G
F
S
S
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
---
A
F
---
Y
P
T
D
A
K
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
-
E
K
A
D
R
K
F
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
P
S
E
K
A
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
-
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
-------------
G
-
T
-
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
--
A
F
S
--
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
--------------------------------------
22
PsiBlast_CBE
88.49
37%
-96
- C7 -
1POX
5
POXB_LACPL
B:
[5-545]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
S
A
E
D
------
W
-
Y
-
A
S
A
N
N
Y
-
Q
T
-
P
L
LP
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
V
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
AK
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
30
PsiBlast_CBE
88.47
37%
-96
- C7 -
2EZ4
5
POXB_LACPL
B:
[13-553]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
LP
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
AK
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
2
PsiBlast_PDB
88.46
37%
-94
- C7 -
1POX
5
POXB_LACPL
A:
[5-545]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
S
A
E
D
------
W
-
Y
-
A
S
A
N
N
Y
-
Q
T
-
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
V
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
5
PsiBlast_PDB
88.44
37%
-97
- C7 -
4KGD
9
?
A:
[13-553]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
26
PsiBlast_CBE
88.38
37%
-97
- C7 -
2EZU
4
POXB_LACPL
B:
[13-553]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
LP
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
AK
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
3
PsiBlast_PDB
88.36
37%
-97
- C7 -
4FEE
9
?
A:
[13-553]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
L
P
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
V
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
---
E
V
SKA
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
33
PsiBlast_CBE
88.23
37%
-97
- C7 -
1Y9D
7
POXB_LACPL
B:
[13-553]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
-----
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
--------
Q
T
-
P
L
LP
E
P
D
V
Q
A
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
Y
P
A
K
G
I
V
A
D
R
Y
P
A
Y
L
G
S
A
-
N
R
A
A
Q
K
P
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
-------A--
F
K
N
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
-
E
R
E
S
T
P
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
D
K
Q
E
G
P
L
Q
A
Y
Q
V
L
R
A
V
N
K
I
A
E
P
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
-
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
E
D
T
N
Q
N
D
-
F
I
G
V
-
E
F
N
D
I
D
F
S
K
I
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D
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V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
A
--
Q
H
E
P
V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
24
PsiBlast_CBE
87.30
37%
-96
- C7 -
4FEG
9
?
B:
[13-553]
-----
A
G
A
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
---
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
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V
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A
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R
R
A
Y
A
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Q
G
V
A
V
V
Q
I
P
V
D
L
P
W
Q
Q
I
------
P
A
E
D
------
W
-
Y
-
A
S
A
N
S
Y
-
Q
T
-
P
L
LP
E
P
D
V
Q
A
V
T
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L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
R
K
-
A
G
K
E
L
E
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L
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K
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L
K
I
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M
S
T
Y
P
A
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I
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A
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R
Y
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A
Y
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-
N
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A
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A
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V
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F
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G
N
N
Y
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F
A
---
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F
K
N
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N
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N
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L
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N
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N
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A
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M
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G
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A
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A
A
K
L
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Y
P
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-
R
Q
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F
N
L
A
G
D
G
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M
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V
L
I
D
A
V
I
T
G
D
R
-
P
L
P
A
E
------------------------------------
46
Fugue
87.00
36%
-98
- C7 -
1POX
5
POXB_LACPL
A:
[1-542]
-
T
N
I
L
A
G
A
A
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A
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N
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AEDWY
A
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------
N
-
Y
-
Q
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L
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A
----
A
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Y
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A
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A
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R
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K
A
---
F
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A
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A
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A
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A
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--
Q
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A
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T
G
D
R
-
P
-------------
L
--------------------------