@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04640: (2016-06-07 )
MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANAYGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYDVTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLKCKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNAVRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDTWIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIGRQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN
Atome Classification :
(31 SA)
.........10..-......20........30...--.--....40........50......-..60........70........80........90........100.......110..---.---.-...-120-.-.----..---.....130.......140...-.-.-...150.-.--..--...160.......170.......180.......190--.-.---....---.200-.........210.---......220.......230.....-..240.......250.......260.......270.......280.......290...-.-.-..300.......310.......320.---.-......330.......340.......350.......360.......370.......380.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTKPFYR
D
T
W
A
E-I
D
L
S
A
I
K
E
N
V
S
N
M
K
K
H
I
G
E
H
V
--
H
--
L
M
A
V
V
K
ANAYGHG
D
A
E
T
A
K
A
A
L
-
D
AG
A
S
C
L
A
V
A
I
L
D
E
A
I
S
L
R
KKGLKA
P
I
L
V
L
GAV
P
P
E
Y
V
A
I
A
A
E
Y
D
V
T
L
TG
Y
S
V
E
W
L
Q
---
E
---
A
-
A
R
H-T---K-K----G
S
---
L
H
F
H
L
K
VDTGMNRLGVK-
T
E
E
-
E
-
V
-
Q
N
V
M
A
I
L-D--RN--P
R
L
K
C
K
G
V
F
T
HFATADEKER
G
Y
F
L
M
Q
F
E
R
F
K
E
L
IAP--L-
P
---
L
K
N
L
---
M
V
---
H
CANSAAG
L
R
L
K
K
---
G
F
F
N
A
V
R
F
G
IGMYGLRPSADMSDE-IP
F
Q
LRP
A
F
T
L
H
S
T
L
S
H
V
K
L
I
RKGESVSYGAEYTAEKD
T
W
I
GTVPVG
Y
A
D
G
W
L
R
KLKG-
T
-
D
-
I
L
V
KG
K
R
L
K
I
A
G
R
I
C
M
D
Q
F
M
V
E
L
-DQ---E-YPPG
T
K
V
T
L
I
GRQGDEYI
S
M
D
E
I
AGR
L
E
T
I
N
Y
E
V
A
C
T
ISSRV
P
R
M
F
LENG
S
I
M
E
VRN
P
L
L
Q
V
NISN
5
PsiBlast_PDB
91.94
50%
-136
- C1 -
3HA1
3
?
A:
[4-386]
---
A
P
F
Y
R
D
T
W
V
E
-
V
D
L
D
A
I
Y
N
N
V
T
H
I
K
E
F
I
P
S
D
V
--
E
--
I
F
A
V
V
K
G
N
A
Y
G
H
D
Y
V
P
V
A
K
I
A
L
-
E
A
G
A
T
R
L
A
V
A
F
L
D
E
A
L
V
L
R
R
A
G
I
T
A
P
I
L
V
L
G
P
S
P
P
R
D
I
N
V
A
A
E
N
D
V
A
L
T
V
F
Q
K
E
W
V
D
---
E
---
A
-
I
K
L
-
W
---
D
-
G
----
S
S
T
--
M
K
Y
H
I
N
F
D
S
G
M
G
R
I
G
I
R
-
E
R
K
-
E
-
L
-
K
G
F
L
K
S
L
-
E
--
G
A
--
P
F
L
E
L
E
G
V
Y
T
H
F
A
T
A
D
E
V
E
T
S
Y
F
D
K
Q
Y
N
T
F
L
E
Q
L
S
W
--
L
-
K
E
FG
V
D
P
K
---
F
V
---
H
T
A
N
S
A
A
T
L
R
F
Q
G
---
I
T
F
N
A
V
R
I
G
I
A
M
Y
G
L
S
P
S
V
E
I
R
P
F
-
L
P
F
K
L
E
P
A
L
S
L
H
T
K
V
A
H
I
K
Q
V
I
K
G
D
G
I
S
Y
N
V
T
Y
R
T
K
T
E
E
W
I
A
T
V
A
I
G
Y
A
D
G
W
L
R
R
L
Q
G
-
F
-
E
-
V
L
V
N
G
K
R
V
P
I
V
G
R
V
T
M
D
Q
F
M
I
H
L
-
P
C
---
E
-
V
P
L
G
T
K
V
T
L
I
G
R
Q
G
D
E
Y
I
S
A
T
E
V
A
E
Y
S
G
T
I
N
Y
E
I
I
T
T
I
S
F
R
V
P
R
I
F
I
R
N
G
K
V
V
E
V
I
N
Y
L
-------
1
PsiBlast_PDB
89.65
56%
-131
- C1 -
1SFT
3
ALR_GEOSE
A:
[4-379]
-----
F
H
R
D
T
W
A
E
-
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
--
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
---
E
---
A
S
A
L
Y
-
S
---
G
-
P
----
F
P
---
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
-
K
R
I
V
A
L
I
-
E
--
R
H
--
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
--
L
-
P
---
S
R
P
P
---
L
V
---
H
C
A
N
S
A
A
S
L
R
F
P
D
---
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
H
-
F
-
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
-
P
G
---
P
-
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
H
K
R
I
M
E
V
R
N
---------
21
PsiBlast_CBE
89.34
56%
-126
- C1 -
1SFT
3
ALR_GEOSE
B:
[4-379]
-----
F
H
R
D
T
W
A
E
-
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
--
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
---
E
---
A
S
A
L
Y
-
S
---
G
-
P
----
F
P
---
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
-
K
R
I
V
A
L
I
-
E
--
R
H
--
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
--
L
-
P
---
S
R
P
P
---
L
V
---
H
C
A
N
S
A
A
S
L
R
F
P
D
---
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
H
-
F
-
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
-
P
G
---
P
-
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
H
K
R
I
M
E
V
R
N
---------
2
PsiBlast_PDB
88.44
56%
-128
- C1 -
1BD0
2
ALR_GEOSE
A:
[4-379]
-----
F
H
R
D
T
W
A
E
-
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
--
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
---
E
---
A
S
A
L
Y
-
S
---
G
-
P
----
F
P
---
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
-
K
R
I
V
A
L
I
-
E
--
R
H
--
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
--
L
-
P
---
S
R
P
P
---
L
V
---
H
C
A
N
S
A
A
S
L
R
F
P
D
---
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
H
-
F
-
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
-
P
G
---
P
-
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
H
K
R
I
M
E
V
R
N
---------
22
PsiBlast_CBE
87.68
56%
-127
- C1 -
1BD0
2
ALR_GEOSE
B:
[4-379]
-----
F
H
R
D
T
W
A
E
-
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
--
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
---
E
---
A
S
A
L
Y
-
S
---
G
-
P
----
F
P
---
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
-
K
R
I
V
A
L
I
-
E
--
R
H
--
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
--
L
-
P
---
S
R
P
P
---
L
V
---
H
C
A
N
S
A
A
S
L
R
F
P
D
---
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
H
-
F
-
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
-
P
G
---
P
-
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
H
K
R
I
M
E
V
R
N
---------
48
HHSearch
86.37
54%
-131
- C1 -
1BD0
2
ALR_GEOSE
A:
[4-382]
------
F
H
R
D
T
W
A
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
--
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
-
T
A
L
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
-------
E
-
A
S
A
L
Y
S--
G
-
P
----
F
P
---
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
-
E
-
E
E
T
-
K
R
I
V
A
L
I
-
E
--
R
H
--
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
--
L
-
P
---
S
R
P
P
---
L
V
---
H
C
A
N
S
A
A
S
L
R
F
P
D
---
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
-
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
H
-
F
-
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
-
P
G
---
P
-
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
H
K
R
I
M
E
V
R
N
A
I
G
------
4
PsiBlast_PDB
86.19
51%
-138
- C1 -
3UW6
-
ALR_GEOSE
A:
[4-379]
-----
F
H
R
D
T
W
A
E
-
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
--
I
M
A
S
V
C
G
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
T
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
---
E
---
A
S
A
L
Y
-
S
---
G
-
P
----
F
P
---
I
H
F
H
L
Y
M
D
T
G
M
G
S
L
G
V
K
-
D
E
E
-
E
-
T
-
K
R
I
V
A
L
I
-
E
--
R
H
--
P
H
F
V
L
E
G
L
W
T
W
F
A
T
-------
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
--
L
-
P
---
S
R
P
P
---
L
V
---
H
C
A
N
S
A
A
S
L
R
F
P
D
---
R
T
F
N
M
V
Q
F
G
I
A
M
Y
G
L
A
P
S
P
G
------
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
F
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
K
D
G
W
L
R
R
L
Q
H
-
F
-
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
L
G
D
M
C
M
I
R
L
-
P
G
---
P
-
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
K
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
H
K
R
I
M
E
V
R
N
---------
3
PsiBlast_PDB
86.02
53%
-143
- C1 -
4ILS
-
ALR_GEOSE
A:
[4-379]
-----
F
H
R
D
T
W
A
E
-
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
--
I
M
A
S
V
C
G
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
T
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
---
E
---
A
S
A
L
Y
-
S
---
G
-
P
----
F
P
---
I
H
F
H
L
Y
M
D
T
G
M
G
---
V
K
-
D
E
E
-
E
-
T
-
K
R
I
V
A
L
I
-
E
--
R
H
--
P
H
F
V
L
E
G
L
W
T
W
F
------------
Y
Q
Y
T
R
F
L
H
M
L
E
W
--
L
-
P
---
S
R
P
P
---
L
V
---
F
C
A
N
---
S
L
R
------
R
T
F
N
M
V
Q
F
G
I
A
M
Y
G
L
A
-----------
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
K
D
G
W
L
R
R
L
Q
H
-
F
-
H
-
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
L
M
D
M
C
M
I
R
L
-
P
G
---
P
-
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
K
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
H
K
R
I
M
E
V
R
N
---------
26
PsiBlast_CBE
80.92
45%
-122
- C1 -
3E5P
2
?
B:
[5-370]
-----
W
H
R
P
T
R
L
H
-
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
--
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
-
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
---
A
---
A
-
L
Q
Q
-
L
---
T
-
P
----
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
-
K
Q
A
V
R
F
V
-
Q
--
S
H
--
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
--
L
-
E
---
E
L
P
R
---
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
P
D
---
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
K
L
A
P
--
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
-
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
-
A
E
---
E
-
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--------------------
25
PsiBlast_CBE
80.85
45%
-123
- C1 -
3E5P
6
?
C:
[5-370]
-----
W
H
R
P
T
R
L
H
-
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
--
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
-
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
---
A
---
A
-
L
Q
Q
-
L
---
T
-
P
----
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
-
K
Q
A
V
R
F
V
-
Q
--
S
H
--
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
--
L
-
E
---
E
L
P
R
---
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
P
D
---
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
K
L
A
P
--
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
-
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
-
A
E
---
E
-
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--------------------
24
PsiBlast_CBE
80.61
45%
-122
- C1 -
3E6E
1
?
B:
[5-370]
-----
W
H
R
P
T
R
L
H
-
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
--
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
-
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
---
A
---
A
-
L
Q
Q
-
L
---
T
-
P
----
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
-
K
Q
A
V
R
F
V
-
Q
--
S
H
--
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
--
L
-
E
---
E
L
P
R
---
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
P
D
---
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
K
L
A
P
--
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
-
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
-
A
E
---
E
-
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--------------------
23
PsiBlast_CBE
80.26
45%
-124
- C1 -
3E6E
2
?
C:
[5-370]
-----
W
H
R
P
T
R
L
H
-
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
--
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
-
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
---
A
---
A
-
L
Q
Q
-
L
---
T
-
P
----
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
-
K
Q
A
V
R
F
V
-
Q
--
S
H
--
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
--
L
-
E
---
E
L
P
R
---
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
P
D
---
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
K
L
A
P
--
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
-
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
-
A
E
---
E
-
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--------------------
6
PsiBlast_PDB
79.57
45%
-122
- C1 -
3E5P
5
?
A:
[5-370]
-----
W
H
R
P
T
R
L
H
-
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
--
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
-
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
---
A
---
A
-
L
Q
Q
-
L
---
T
-
P
----
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
-
K
Q
A
V
R
F
V
-
Q
--
S
H
--
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
--
L
-
E
---
E
L
P
R
---
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
P
D
---
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
K
L
A
P
--
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
-
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
-
A
E
---
E
-
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--------------------
53
HHSearch
79.39
46%
-123
* C1 *
3E5P
5
?
A:
[3-371]
---
V
G
W
H
R
P
T
R
L
H
-
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
--
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
-
A
A
K
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
-------
A
-
A
L
Q
Q
L
TPE
S
-
N
----
T
P
---
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
-
P
E
E
-
T
-
K
Q
A
V
R
F
V
-
Q
--
S
H
--
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
--
L
-
E
---
E
L
P
R
---
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
P
D
---
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
K
-
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
-
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
-
A
E
---
E
-
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-------------------
7
PsiBlast_PDB
78.70
45%
-118
- C1 -
3E6E
2
?
A:
[5-370]
-----
W
H
R
P
T
R
L
H
-
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
--
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
-
K
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
---
A
---
A
-
L
Q
Q
-
L
---
T
-
P
----
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
-
T
P
E
-
E
-
T
-
K
Q
A
V
R
F
V
-
Q
--
S
H
--
K
E
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
--
L
-
E
---
E
L
P
R
---
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
P
D
---
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
K
L
A
P
--
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
-
F
-
T
-
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
-
A
E
---
E
-
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--------------------
14
PsiBlast_PDB
77.82
36%
-131
- C1 -
4Y2W
3
ALR1_CALS4
A:
[7-378]
-------
R
P
T
R
V
E
-
V
Y
L
D
A
I
T
H
N
F
R
E
I
K
K
I
V
G
K
N
V
--
K
--
I
M
A
V
I
K
G
D
A
Y
G
H
G
A
S
Y
V
A
K
F
L
E
-
K
E
G
V
D
Y
F
G
V
A
T
T
E
E
A
L
E
L
R
E
K
G
I
K
T
P
I
L
I
F
G
Y
T
P
P
T
Q
L
R
Q
I
V
K
H
D
L
T
Q
T
V
Y
D
I
K
Y
A
K
---
E
---
L
-
E
K
E
-
S
---
L
-
K
----
Q
N
K
R
-
A
K
V
H
I
K
I
D
T
G
L
G
R
I
G
Y
I
-
D
F
D
-
L
-
A
-
Q
K
E
I
L
E
M
-
A
--
N
M
--
R
G
L
I
L
E
G
I
Y
S
H
F
A
A
A
S
E
D
D
R
D
Y
C
K
E
Q
F
D
K
F
M
N
L
I
S
S
--
L
-
E
---
K
K
R
L
---
K
I
P
L
K
H
I
A
N
A
A
A
I
L
N
L
N
Y
---
S
H
L
D
M
V
R
P
G
I
I
L
F
G
A
Y
P
S
K
R
V
E
R
K
-
V
--
E
L
R
E
T
L
R
F
T
T
R
V
V
H
L
K
D
V
P
A
G
F
F
I
G
Y
G
K
S
F
V
T
K
R
K
S
V
I
A
T
I
P
V
G
Y
A
D
G
L
D
R
R
L
S
N
-
N
Y
K
-
L
L
L
K
G
K
Y
V
P
I
V
G
R
V
C
M
D
Q
C
M
I
D
V
T
D
V
---
E
G
V
E
I
G
D
E
V
V
I
I
G
T
Q
N
N
E
T
V
S
V
E
S
M
A
D
K
I
E
T
I
P
Q
E
V
F
S
R
I
S
R
R
V
P
R
V
Y
F
Y
D
G
----------------
8
PsiBlast_PDB
77.46
40%
-127
- C1 -
3OO2
3
ALR1_STAAC
A:
[5-385]
-
S
D
K
-
Y
Y
R
S
A
Y
M
N
-
V
D
L
N
A
V
---
A
S
N
F
K
V
F
S
T
L
H
P
--
N
KT
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
-
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
L
V
L
G
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
---
E
---
A
-
I
K
N
-
I
SGE
Q
-
E
----
K
K
---
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
-
D
T
K
-
T
-
Y
-
Q
E
V
I
E
I
I
-
Q
--
Q
Y
--
E
Q
L
V
F
E
G
V
F
T
H
F
A
C
A
D
E
P
-
G
D
M
T
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
----
A
---
I
K
P
E
---
Y
I
---
H
C
Q
N
S
A
G
S
L
L
M
D
C
---
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
G
E
S
V
S
Y
G
--
Y
T
A
T
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
G
-
S
-
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
-
P
D
---
Q
-
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
-
H
D
G
D
Q
R
F
V
T
N
E
L
L
K
-----
31
PsiBlast_CBE
77.10
36%
-130
- C1 -
4Y2W
3
ALR1_CALS4
B:
[7-378]
-------
R
P
T
R
V
E
-
V
Y
L
D
A
I
T
H
N
F
R
E
I
K
K
I
V
G
K
N
V
--
K
--
I
M
A
V
I
K
G
D
A
Y
G
H
G
A
S
Y
V
A
K
F
L
E
-
K
E
G
V
D
Y
F
G
V
A
T
T
E
E
A
L
E
L
R
E
K
G
I
K
T
P
I
L
I
F
G
Y
T
P
P
T
Q
L
R
Q
I
V
K
H
D
L
T
Q
T
V
Y
D
I
K
Y
A
K
---
E
---
L
-
E
K
E
-
S
---
L
-
K
----
Q
N
KR-
A
K
V
H
I
K
I
D
T
G
L
G
R
I
G
Y
I
-
D
F
D
-
L
-
A
-
Q
K
E
I
L
E
M
-
A
--
N
M
--
R
G
L
I
L
E
G
I
Y
S
H
F
A
A
A
S
E
D
D
R
D
Y
C
K
E
Q
F
D
K
F
M
N
L
I
S
S
--
L
-
E
---
K
K
R
L
---
K
I
PLK
H
I
A
N
A
A
A
I
L
N
L
N
Y
---
S
H
L
D
M
V
R
P
G
I
I
L
F
G
A
Y
P
S
K
R
V
E
R
K
-
V
--
E
L
R
E
T
L
R
F
T
T
R
V
V
H
L
K
D
V
P
A
G
F
F
I
G
Y
G
K
S
F
V
T
K
R
K
S
V
I
A
T
I
P
V
G
Y
A
D
G
L
D
R
R
L
S
N
-
N
Y
K
-
L
L
L
K
G
K
Y
V
P
I
V
G
R
V
C
M
D
Q
C
M
I
D
V
T
D
V
---
E
G
V
E
I
G
D
E
V
V
I
I
G
T
Q
N
N
E
T
V
S
V
E
S
M
A
D
K
I
E
T
I
P
Q
E
V
F
S
R
I
S
R
R
V
P
R
V
Y
F
Y
D
G
----------------
12
PsiBlast_PDB
77.07
38%
-127
- C1 -
4LUY
-
?
A:
[8-385]
---------
T
W
A
E
-
I
N
L
D
N
L
R
F
N
L
N
N
I
K
N
L
L
E
E
D
I
--
K
--
I
C
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
L
L
E
-
K
E
K
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
P
I
L
N
L
G
Y
T
P
D
E
A
F
E
D
S
I
K
N
K
I
T
M
T
V
Y
S
L
E
T
A
Q
K
I
N
E
---
I
-
A
K
S
-
L
---
G
-
E
----
K
A
---
C
-
V
H
V
-
I
D
S
G
M
T
R
I
G
F
Q
P
N
E
E
-
S
-
V
-
Q
E
I
I
E
-
L
-
N
--
K
L
--
E
Y
I
D
L
E
G
M
F
T
H
F
A
T
A
D
E
V
S
K
E
Y
T
Y
K
Q
A
N
N
Y
K
F
M
S
D
K
--
L
-
D
E
AG
V
K
I
A
---
I
K
---
H
V
S
N
S
A
A
I
M
D
C
P
D
---
L
R
L
N
M
V
R
A
G
I
I
L
Y
G
H
Y
P
S
D
D
V
F
K
D
--
R
L
E
L
R
P
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
T
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
F
T
R
I
Q
K
N
-
P
-
K
-
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
-
D
K
DI-
D
-
I
K
V
G
D
E
V
I
L
F
G
-
E
G
E
--
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
M
E
N
N
E
L
V
Q
I
N
S
Y
L
L
K
-----
54
HHSearch
75.10
36%
-129
- C1 -
4Y2W
3
ALR1_CALS4
A:
[4-383]
----
D
G
V
R
P
T
R
V
E
-
V
Y
L
D
A
I
T
H
N
F
R
E
I
K
K
I
V
G
K
N
V
--
K
--
I
M
A
V
I
K
G
D
A
Y
G
H
G
A
S
Y
V
A
K
-
F
L
E
K
E
G
V
D
Y
F
G
V
A
T
T
E
E
A
L
E
L
R
E
K
G
I
K
T
P
I
L
I
F
G
Y
T
P
P
T
Q
L
R
Q
I
V
K
H
D
L
T
Q
T
V
Y
D
I
K
Y
A
K
-------
E
-
L
E
K
E
S
L
K
-
Q
-
N
----
K
R
---
A
K
V
H
I
K
I
D
T
G
L
G
R
I
G
Y
I
-
D
-
F
-
D
-
L
A
Q
K
E
I
L
E
M
-
A
--
N
M
--
R
G
L
I
L
E
G
I
Y
S
H
F
A
A
A
S
E
D
D
R
D
Y
C
K
E
Q
F
D
K
F
M
N
L
I
S
S
L
E
K
K
R
---
L
K
I
P
---
L
K
---
H
I
A
N
A
A
A
I
L
N
L
N
Y
---
S
H
L
D
M
V
R
P
G
I
I
L
F
G
A
Y
P
S
K
R
--
V
E
-
R
K
V
E
L
R
E
T
L
R
F
T
T
R
V
V
H
L
K
D
V
P
A
G
F
F
I
G
Y
G
K
S
F
V
T
K
R
K
S
V
I
A
T
I
P
V
G
Y
A
D
G
L
D
R
R
L
S
N
-
N
-
Y
K
L
L
L
K
G
K
Y
V
P
I
V
G
R
V
C
M
D
Q
C
M
I
D
V
-
T
D
VE-
G
-
V
E
I
G
D
E
V
V
I
I
G
T
Q
N
N
E
T
V
S
V
E
S
M
A
D
K
I
E
T
I
P
Q
E
V
F
S
R
I
S
R
R
V
P
R
V
Y
F
Y
D
G
I
K
I
G
E
-----------
60
HHSearch
74.67
40%
-136
- C1 -
4A3Q
10
ALR1_STAAM
A:
[2-375]
-
S
D
K
-
Y
Y
R
S
A
Y
M
N
-
V
D
L
N
A
V
A
S
N
F
K
V
F
S
T
L
H
P
-
N
K
--
T
--
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
-
H
L
M
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
L
V
L
G
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
-------
E
-
A
I
K
N
I
SGE
Q
-
E
----
K
K
---
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
-
D
-
T
-
N
T
Y
-
Q
E
V
I
E
I
I
-
Q
--
Q
Y
--
E
Q
L
V
F
E
G
V
F
T
H
F
--------
D
M
T
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
----
A
---
I
K
P
E
---
Y
I
---
H
C
Q
N
S
A
G
S
L
L
M
D
C
---
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
------------------
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
G
-
S
-
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
-
P
D
---
Q
-
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
H
D
G
D
Q
R
F
-------------
10
PsiBlast_PDB
71.49
38%
-125
- C1 -
4LUT
2
?
A:
[8-384]
---------
T
W
A
E
-
I
N
L
D
N
L
R
F
N
L
N
N
I
K
N
L
L
E
E
D
I
--
K
--
I
C
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
L
L
E
-
K
E
K
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
P
I
L
N
L
G
Y
T
P
D
E
A
F
E
D
S
I
K
N
K
I
T
M
T
V
Y
S
L
E
T
A
Q
K
I
N
E
---
I
-
A
K
S
-
L
---
G
-
E
----
K
A
---
C
-
V
H
V
K
I
D
-------
F
Q
P
N
E
E
-
S
-
V
-
Q
E
I
I
E
-
L
-
N
--
K
L
--
E
Y
I
D
L
E
G
M
F
T
H
F
A
T
A
D
E
V
S
K
E
Y
T
Y
K
Q
A
N
N
Y
K
F
M
S
D
K
--
L
-
D
E
A
G
V
K
I
A
---
I
K
---
H
V
S
N
S
A
A
I
M
D
C
P
D
---
L
R
L
N
M
V
R
A
G
I
I
L
Y
G
H
Y
P
S
D
D
V
F
K
D
--
R
L
E
L
R
P
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
K
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
F
T
R
I
Q
K
N
-
P
-
K
-
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
-
D
K
D
I
-
D
-
I
K
V
G
D
E
V
I
L
F
G
-
E
G
E
--
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
M
E
N
N
E
L
V
Q
I
N
S
Y
L
L
------
28
PsiBlast_CBE
70.69
40%
-127
- C1 -
4A3Q
11
ALR1_STAAM
B:
[2-382]
-
S
D
K
-
Y
Y
R
S
A
Y
M
N
-
V
D
L
N
A
V
---
A
S
N
F
K
V
F
S
T
L
H
P
--
N
KT
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
-
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
L
V
L
G
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
---
E
---
A
-
I
K
N
-
I
SGE
Q
-
E
----
K
K
---
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
-
D
T
N
-
T
-
Y
-
Q
E
V
I
E
I
I
-
Q
--
Q
Y
--
E
Q
L
V
F
E
G
V
F
T
H
F
----------
T
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
----
A
---
I
K
P
E
---
Y
I
---
H
C
Q
N
S
A
G
S
L
L
M
D
C
---
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
----------------
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
G
-
S
-
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
-
P
D
---
Q
-
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
-
H
D
G
D
Q
R
F
V
T
N
E
L
L
K
-----
9
PsiBlast_PDB
70.28
40%
-127
- C1 -
4A3Q
10
ALR1_STAAM
A:
[2-382]
-
S
D
K
-
Y
Y
R
S
A
Y
M
N
-
V
D
L
N
A
V
---
A
S
N
F
K
V
F
S
T
L
H
P
--
N
KT
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
-
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
L
V
L
G
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
---
E
---
A
-
I
K
N
-
I
SGE
Q
-
E
----
K
K
---
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
-
D
T
N
-
T
-
Y
-
Q
E
V
I
E
I
I
-
Q
--
Q
Y
--
E
Q
L
V
F
E
G
V
F
T
H
F
--------
D
M
T
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
----
A
---
I
K
P
E
---
Y
I
---
H
C
Q
N
S
A
G
S
L
L
M
D
C
---
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
------------------
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
G
-
S
-
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
-
P
D
---
Q
-
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
-
H
D
G
D
Q
R
F
V
T
N
E
L
L
K
-----
27
PsiBlast_CBE
69.77
40%
-125
- C1 -
3OO2
3
ALR1_STAAC
B:
[5-385]
-
S
D
K
-
Y
Y
R
S
A
Y
M
N
-
V
D
L
N
A
V
---
A
S
N
F
K
V
F
S
T
L
H
P
--
N
KT
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
-
E
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
I
L
V
L
G
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
---
E
---
A
-
I
K
N
-
I
S---------
K
K
---
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
-
D
T
K
-
T
-
Y
-
Q
E
V
I
E
I
I
-
Q
--
Q
Y
--
E
Q
L
V
F
E
G
V
F
T
H
F
A
C
A
D
E
P
-
G
D
M
T
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
----
A
---
I
K
P
E
---
Y
I
---
H
C
Q
N
S
A
G
S
L
L
M
D
C
---
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
-------------
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
G
-
S
-
F
-
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
-
P
D
---
Q
-
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
-
H
D
G
D
Q
R
F
V
T
N
E
L
L
K
-----
32
PsiBlast_CBE
66.45
35%
-123
- C1 -
1XFC
1
ALR_MYCTU
B:
[14-380]
-----------
A
M
-
V
D
L
G
A
I
E
H
N
V
R
V
L
R
E
H
A
G
-
H
A
--
Q
--
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
-
G
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
L
A
W
L
H
P
P
G
I
D
F
G
P
A
L
L
A
D
V
Q
V
A
V
S
S
L
R
Q
L
D
---
E
L
L
H
A
-
V
R
R
-
T
---
G
-
R
-----
T
---
A
T
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
-
P
A
Q
-
F
-
P
-
A
M
L
T
A
L
R
-
Q
A
M
A
E
--
D
A
V
R
L
R
G
L
M
S
H
M
V
Y
A
D
K
P
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
--
A
-
R
---
E
Q
G
V
RFE
V
A
---
H
L
S
N
S
S
A
T
M
A
R
P
D
---
L
T
F
D
L
V
R
P
G
I
A
V
Y
G
L
S
P
V
P
A
L
G
D
----
M
G
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
---------------
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
G
R
L
-
E
-
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
-
G
P
GPL
D
-
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
R
E
------------------
50
HHSearch
65.83
37%
-118
- C1 -
3CO8
1
LYSR_OENOB
A:
[3-371]
--
L
E
A
I
H
R
S
T
R
I
E
-
F
S
K
S
S
L
A
Y
N
V
Q
Y
T
K
Q
V
S
G
-
A
K
--
T
--
L
W
L
A
V
K
S
N
A
Y
G
H
G
L
L
Q
V
S
K
-
I
A
R
E
C
G
V
D
G
L
A
V
S
V
L
D
E
G
I
A
I
R
Q
A
G
I
D
D
F
I
L
I
L
G
P
I
D
V
K
Y
A
P
I
A
S
K
Y
H
F
L
T
T
V
S
S
L
D
W
L
K
-------
S
-
A
D
K
-
I
L--
G
-
K
----
E
K
---
L
S
V
N
L
A
V
D
T
G
M
N
R
I
G
V
R
-
S
-
K
K
D
-
L
-
K
D
E
I
E
F
L
-
Q
E
-
H
S
--
D
H
F
S
Y
D
G
I
F
T
H
F
A
---------
F
Q
R
Q
K
N
R
W
Y
E
L
I
D
G
----
L
---
I
M
P
R
---
Y
V
---
H
V
M
N
S
G
A
A
M
Y
H
S
K
ELP
G
C
N
S
I
A
R
V
G
T
V
V
Y
G
V
E
P
S
E
G
V
-
L
G
-
P
I
D
K
L
K
P
V
F
E
L
K
S
A
L
T
F
V
K
K
I
P
A
G
E
G
I
S
Y
G
S
K
F
V
T
S
R
D
T
W
I
G
T
L
P
I
G
Y
G
D
G
W
L
A
E
Y
Q
D
-
F
-
Q
-
L
L
I
D
G
Q
K
C
R
Q
V
G
Q
I
A
M
D
Q
M
M
V
A
L
-
P
H
---
E
-
Y
P
I
G
T
E
V
T
L
I
G
K
S
G
K
Y
E
N
T
L
Y
D
L
H
K
H
S
G
V
P
P
W
K
I
T
V
A
F
S
D
R
L
K
R
M
V
V
-------------------
15
PsiBlast_PDB
65.38
35%
-117
- C1 -
3CO8
1
LYSR_OENOB
A:
[3-371]
--
L
E
A
I
H
R
S
T
R
I
E
-
F
S
K
S
S
L
A
Y
N
V
Q
Y
T
K
Q
V
S
G
A
K
T
--
L
--
W
L
A
V
-
K
S
N
A
Y
G
H
G
L
L
Q
V
S
K
I
A
R
-
E
C
G
V
D
G
L
A
V
S
V
L
D
E
G
I
A
I
R
Q
A
G
I
D
D
F
I
L
I
L
G
P
I
D
V
K
Y
A
P
I
A
S
K
Y
H
F
L
T
T
V
S
S
L
D
W
L
K
---
S
---
A
-
D
K
I
-
L
---
G
-
K
----
E
K
---
L
S
V
N
L
A
V
D
T
G
M
N
R
I
G
V
R
-
S
K
K
-
D
-
L
-
K
D
E
I
E
F
L
Q
E
--
H
S
--
D
H
F
S
Y
D
G
I
F
T
H
F
A
---------
F
Q
R
Q
K
N
R
W
Y
E
L
I
D
G
--
L
-----
I
M
P
R
---
Y
V
---
H
V
M
N
S
G
A
A
M
Y
H
S
K
ELP
G
C
N
S
I
A
R
V
G
T
V
V
Y
G
V
E
P
S
E
G
V
L
G
P
-
I
D
-
K
L
K
P
V
F
E
L
K
S
A
L
T
F
V
K
K
I
P
A
G
E
G
I
S
Y
G
S
K
F
V
T
S
R
D
T
W
I
G
T
L
P
I
G
Y
G
D
G
W
L
A
E
Y
Q
D
-
F
-
Q
-
L
L
I
D
G
Q
K
C
R
Q
V
G
Q
I
A
M
D
Q
M
M
V
A
L
-
P
H
---
E
-
Y
P
I
G
T
E
V
T
L
I
G
K
S
G
K
Y
E
N
T
L
Y
D
L
H
K
H
S
G
V
P
P
W
K
I
T
V
A
F
S
D
R
L
K
R
M
V
V
-------------------
16
PsiBlast_PDB
64.76
35%
-120
- C1 -
1XFC
1
ALR_MYCTU
A:
[14-380]
-----------
A
M
-
V
D
L
G
A
I
E
H
N
V
R
V
L
R
E
H
A
G
-
H
A
--
Q
--
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
-
G
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
L
A
W
L
H
P
P
G
I
D
F
G
P
A
L
L
A
D
V
Q
V
A
V
S
S
L
R
Q
L
D
---
E
L
L
H
A
-
V
R
R
-
T
---
G
-
R
-----
T
---
A
T
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
-
P
A
Q
-
F
-
P
-
A
M
L
T
A
L
R
-
Q
A
M
A
E
--
D
A
V
R
L
R
G
L
M
S
H
M
-----
P
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
--
A
-
R
---
E
Q
G
V
RFE
V
A
---
H
L
S
N
S
S
A
T
M
A
R
P
D
---
L
T
F
D
L
V
R
P
G
I
A
V
Y
G
L
S
P
V
P
A
L
G
D
----
M
G
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
A
G
E
G
V
S
Y
G
H
T
W
I
A
P
R
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
G
R
L
-
E
-
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
-
G
P
GPL
D
-
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
R
E
------------------
42
Fugue
62.32
53%
-147
- C1 -
1BD0
1
ALR_GEOSE
A:
[12-244]
--------------
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
--D
T
H
--
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
---
E
---
A
-
S
A
L
-
Y
------SGP
F
-
P
---
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
-
K
R
I
V
A
L
I
-
E
----
R
H
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
--
L
-
P
---
S
--
R
PP-
L
V
---
H
C
A
N
S
A
A
S
L
R
F
P
D
---
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
62.05
51%
-138
- C1 -
1BD0
1
ALR_GEOSE
A:
[12-244]
--------------
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
--
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
---
E
---
A
-
S
A
L
-
Y
---
S
G
P
----
F
P
---
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
-
D
E
E
-
E
-
T
-
K
R
I
V
A
L
I
-
E
--
R
H
--
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
--
L
-
P
---
S
R
P
P
---
L
V
---
H
C
A
N
S
A
A
S
L
R
F
P
D
---
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
-
L
P
Y
P
L
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------