@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04800: (2016-06-08 )
MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFETWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEALGEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHPEIKAISFVGSKPVGEYVYKKGSEHLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKVVTARFPAPDFN
Atome Classification :
(20 SA)
.........10........20-........30-........40........50.......--.--60........70........80........90........100-.-.-.....110.......120.......130.......------140.......150.......160.......170.......180.......190---........200.....-..210....-...220.......230.......240.------.......250.......260.......270.......280.......-290.......300.......310.....-..320.......330.......340.......350...---..---..360---.........370.......380.......390..--.....400.......410.......420....--...430.......440-.......450.......460........470.......480.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
E
I
R
K
L
K
N
Y
IN
G
E
WVESK
T
D
-
Q
Y
E
D
VVNPA
T
-
K
E
V
LCQVPISTK
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
E
--
T
--
W
S
K
VAVP
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
IENGK
N
T
K
E
A
L
-
G
-
E
-
V
GRGIENVEFAAGAP
S
L
M
MG
D
S
L
A
S
I
A
T
DVEAANY------RYPIGVVGGIAPFNFPMM
V
P
C
W
M
F
P
M
A
I
ALG
N
T
F
I
LKPSERTP
L
L
T
E
K
L
V
E
L
----
F
E
KAGLP
K
G
V
F
N
V
V
YG-
A
H
D
V
V
N
G
I
L-EHPE
I
K
A
I
S
FVGSK
P
V
G
E
Y
V
Y
K
K
G
S
-
E
------
H
L
K
R
V
Q
S
L
TGAKN
H
T
I
V
L
NDAN
L
E
D
T
V
T
N
I
V
G
A
A
FGSAGE
R
C
M
A
C
A
V
-
V
T
V
EEG
I
A
D
E
F
M
A
K
L
Q
E
K
VA
D
I
KIGNGL-DDG
V
F
L
G
P
V
IREDN
K
K
R
T
L
S
Y
I
E
K
G
L
EEG
A
R
L
V
CDGRE---NV---SDD-----G
Y
F
VGPTIFDNVTT
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
--
N
L
K
E
A
I
E
I
A
N
K
S
EFAN
G
A
C
L
FTSNS
N
A
I
R
Y
F
R
--
E
NIDAG
M
L
G
I
NLGVPA-P
M
A
F
FPFSGWKSS
F
F
G
T
LH-ANGKDS
V
D
F
Y
T
R
K
K
V
V
T
ARFPAPDFN
21
PsiBlast_CBE
93.95
99%
-87
- C4 -
1T90
1
IOLA_BACSU
D:
[2-485]
--
E
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
-
Q
Y
E
D
V
V
N
P
A
T
-
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
--
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
-
G
-
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
------
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
----
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
H
D
V
V
N
G
I
L
-
E
H
P
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
K
K
G
S
-
E
------
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
-
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
---
N
V
---
S
D
D
-----
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
--
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
--
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
-
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
-
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-
22
PsiBlast_CBE
93.37
99%
-85
- C4 -
1T90
1
IOLA_BACSU
C:
[2-485]
--
E
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
-
Q
Y
E
D
V
V
N
P
A
T
-
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
--
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
-
G
-
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
------
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
----
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
H
D
V
V
N
G
I
L
-
E
H
P
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
K
K
G
S
-
E
------
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
-
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
---
N
V
---
S
D
D
-----
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
--
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
--
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
-
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
-
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-
1
PsiBlast_PDB
93.32
99%
-85
- C4 -
1T90
1
IOLA_BACSU
A:
[2-485]
--
E
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
-
Q
Y
E
D
V
V
N
P
A
T
-
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
--
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
-
G
-
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
------
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
----
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
H
D
V
V
N
G
I
L
-
E
H
P
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
K
K
G
S
-
E
------
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
-
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
---
N
V
---
S
D
D
-----
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
--
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
--
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
-
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
-
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-
109
HHSearch
93.11
99%
-85
- C4 -
1T90
1
IOLA_BACSU
A:
[2-485]
--
E
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
-
Q
Y
E
D
V
V
N
P
A
T
-
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
--
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
-
G
-
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
------
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
----
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
H
D
V
V
N
G
I
L
-
E
H
P
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
K
K
G
S
-
E
------
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
-
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
---
N
V
---
S
D
D
-----
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
--
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
--
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
-
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
-
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-
23
PsiBlast_CBE
92.99
99%
-82
- C4 -
1T90
1
IOLA_BACSU
B:
[2-485]
--
E
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
-
Q
Y
E
D
V
V
N
P
A
T
-
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
--
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
-
G
-
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
------
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
----
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
H
D
V
V
N
G
I
L
-
E
H
P
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
K
K
G
S
-
E
------
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
-
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
---
N
V
---
S
D
D
-----
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
--
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
--
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
-
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
-
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-
114
HHSearch
78.46
42%
-96
- C4 -
4IYM
3
?
A:
[24-508]
---
M
Y
E
L
G
H
F
I
D
G
K
R
V
A
G
T
S
G
-
R
V
S
N
I
F
N
P
A
T
-
G
E
V
Q
G
T
V
A
L
A
S
D
A
D
L
A
A
A
V
E
S
A
K
A
A
Q
P
--
K
--
W
A
A
T
N
P
Q
R
R
A
R
V
F
M
K
F
V
Q
L
L
N
D
N
M
N
E
L
A
E
M
L
S
R
E
H
G
K
T
I
D
D
A
K
-
G
-
D
-
I
V
R
G
L
E
V
C
E
F
V
I
G
I
P
H
L
Q
K
S
E
F
T
E
G
A
G
P
G
I
D
M
Y
S
I
------
R
Q
P
V
G
I
G
A
G
I
T
P
F
N
F
P
G
M
I
P
M
W
M
F
A
P
A
I
A
C
G
N
A
F
I
L
K
P
S
E
R
D
P
S
V
P
I
R
L
A
E
L
----
M
I
E
A
G
L
P
A
G
I
L
N
V
V
N
G
-
D
K
G
A
V
D
A
I
L
-
T
H
P
D
I
A
A
V
S
F
V
G
S
T
P
I
A
R
Y
V
Y
G
T
A
A
-
M
------
N
G
K
R
A
Q
C
F
G
G
A
K
N
H
M
I
I
M
P
D
A
D
L
D
Q
A
A
N
A
L
I
G
A
G
Y
G
S
A
G
E
R
C
M
A
I
S
V
A
V
P
V
G
E
E
T
A
N
R
L
I
D
K
L
V
P
M
V
E
S
L
R
I
G
P
Y
T
-
D
E
K
A
D
M
G
P
V
V
T
K
E
A
E
Q
R
I
R
S
L
I
D
S
G
I
E
Q
G
A
K
L
V
V
D
G
R
D
---
F
K
L
Q
G
Y
E
N
-----
G
H
F
I
G
G
C
L
F
D
D
V
T
P
D
M
D
I
Y
K
T
E
I
F
G
P
V
L
S
V
V
R
A
R
--
N
Y
E
E
A
L
S
L
P
M
K
H
E
Y
G
N
G
V
A
I
Y
T
R
D
G
D
A
A
R
D
F
A
--
S
R
I
N
I
G
M
V
G
V
N
V
P
I
P
V
-
P
L
A
Y
H
S
F
G
G
W
K
S
S
S
F
G
-
D
L
N
Q
H
G
T
D
S
I
K
F
W
T
R
T
K
T
I
T
S
R
W
P
S
G
---
2
PsiBlast_PDB
78.35
44%
-86
- C4 -
4ZZ7
1
?
A:
[4-486]
---
M
T
T
I
G
H
L
I
N
G
Q
L
V
T
E
N
T
--
R
S
Q
N
V
F
N
P
A
T
-
G
E
I
G
K
Q
L
D
L
A
S
T
K
T
V
E
Q
A
I
S
A
A
Q
H
A
F
P
--
T
--
W
R
N
T
P
P
L
K
R
A
R
V
M
F
R
F
K
E
L
L
E
Q
H
A
D
E
I
C
R
L
I
G
E
E
H
G
K
I
A
H
D
A
M
-
G
-
E
-
L
Q
R
G
I
E
N
V
E
Y
A
C
G
A
P
E
L
L
K
G
E
H
S
R
N
V
G
P
G
I
D
S
W
S
E
------
F
Q
P
M
G
V
V
A
G
I
T
P
F
N
F
P
V
M
V
P
L
W
M
F
P
M
A
I
V
C
G
N
C
F
V
L
K
P
S
E
R
D
P
S
S
T
L
Y
I
A
Q
L
----
L
Q
E
A
G
L
P
D
G
V
M
N
V
V
N
G
-
D
K
E
A
V
D
A
L
L
-
H
D
D
R
V
K
A
V
S
F
V
G
S
T
P
I
A
E
Y
I
Y
R
T
A
S
-
A
------
N
G
K
R
C
Q
A
L
G
G
A
K
N
H
A
I
V
M
P
D
A
D
M
D
N
A
V
N
Q
L
L
G
A
A
F
G
S
S
G
E
R
C
M
A
L
S
V
A
V
A
V
G
D
A
A
G
D
A
L
V
S
K
M
T
Q
A
M
Q
K
L
K
V
G
P
S
T
-
D
S
G
N
D
F
G
P
V
I
T
R
Q
H
Q
E
K
V
I
G
Y
I
N
S
A
E
Q
Q
G
A
T
I
V
V
D
G
R
Q
---
P
K
VPN
H
E
N
-----
G
F
F
V
G
G
T
L
I
D
H
V
T
P
E
M
T
S
Y
Q
E
E
I
F
G
P
V
L
Q
V
V
R
V
A
--
T
M
Q
D
A
M
D
L
I
D
A
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
Y
F
S
--
D
N
I
Q
V
G
M
V
G
I
N
I
P
L
P
V
-
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
-
A
Y
G
P
D
A
V
R
F
Y
T
K
R
K
T
V
T
Q
R
W
P
S
----
4
PsiBlast_PDB
77.11
41%
-94
- C4 -
4IYM
3
?
A:
[26-507]
-----
E
L
G
H
F
I
D
G
K
R
V
A
G
T
S
G
-
R
V
S
N
I
F
N
P
A
T
-
G
E
V
Q
G
T
V
A
L
A
S
D
A
D
L
A
A
A
V
E
S
A
K
A
A
Q
P
--
K
--
W
A
A
T
N
P
Q
R
R
A
R
V
F
M
K
F
V
Q
L
L
N
D
N
M
N
E
L
A
E
M
L
S
R
E
H
G
K
T
I
D
D
A
K
-
G
-
D
-
I
V
R
G
L
E
V
C
E
F
V
I
G
I
P
H
L
Q
K
S
E
F
T
E
G
A
G
P
G
I
D
M
Y
S
I
------
R
Q
P
V
G
I
G
A
G
I
T
P
F
N
F
P
G
M
I
P
M
W
M
F
A
P
A
I
A
C
G
N
A
F
I
L
K
P
S
E
R
D
P
S
V
P
I
R
L
A
E
L
----
M
I
E
A
G
L
P
A
G
I
L
N
V
V
N
G
-
D
K
G
A
V
D
A
I
L
-
T
H
P
D
I
A
A
V
S
F
V
G
S
T
P
I
A
R
Y
V
Y
G
T
A
A
-
M
------
N
G
K
R
A
Q
C
F
G
G
A
K
N
H
M
I
I
M
P
D
A
D
L
D
Q
A
A
N
A
L
I
G
A
G
Y
G
S
A
G
E
R
C
M
A
I
S
V
A
V
P
V
G
E
E
T
A
N
R
L
I
D
K
L
V
P
M
V
E
S
L
R
I
G
P
Y
T
-
D
E
K
A
D
M
G
P
V
V
T
K
E
A
E
Q
R
I
R
S
L
I
D
S
G
I
E
Q
G
A
K
L
V
V
D
G
R
D
F
K
L
Q
G
---
Y
E
N
-----
G
H
F
I
G
G
C
L
F
D
D
V
T
P
D
M
D
I
Y
K
T
E
I
F
G
P
V
L
S
V
V
R
A
R
--
N
Y
E
E
A
L
S
L
P
M
K
H
E
Y
G
N
G
V
A
I
Y
T
R
D
G
D
A
A
R
D
F
A
--
S
R
I
N
I
G
M
V
G
V
N
V
P
I
P
V
-
P
L
A
Y
H
S
F
G
G
W
K
S
S
S
F
G
D
L
N
-
Q
H
G
T
D
S
I
K
F
W
T
R
T
K
T
I
T
S
R
W
P
S
----
129
HHSearch
74.61
34%
-83
- C4 -
4PXL
11
?
A:
[33-512]
--
E
V
R
F
T
K
L
F
I
D
G
K
F
V
D
A
V
S
G
-
K
T
F
E
T
R
D
P
R
T
-
G
E
V
I
A
S
I
A
E
G
D
K
A
D
V
D
L
A
V
K
A
A
R
E
A
F
D
NG
P
--
W
P
R
M
T
G
Y
E
R
G
R
I
L
H
R
F
A
D
L
I
D
E
H
V
E
E
L
A
A
L
D
T
V
D
A
G
K
L
F
A
V
G
K
A
R
-
D
-
I
P
G
A
A
H
L
L
R
Y
Y
A
G
A
A
D
K
V
H
G
A
T
L
K
-
M
A
Q
R
M
H
G
Y
T
L
------
K
E
P
V
G
V
V
G
H
I
V
P
W
N
Y
P
T
T
M
F
F
F
K
V
G
P
A
L
A
A
G
C
A
V
V
V
K
P
A
E
Q
T
P
L
S
A
L
F
Y
A
H
L
----
A
R
E
A
G
V
P
A
G
V
L
N
V
V
P
G
F
G
P
T
A
G
A
A
V
A
-
A
H
M
D
V
D
K
V
S
F
T
G
S
T
E
V
G
R
L
V
M
R
A
A
A
-
E
S
-----
N
L
K
P
V
S
L
E
L
G
G
K
S
P
V
I
V
F
D
D
A
D
L
D
M
A
V
N
L
V
N
F
A
T
Y
T
N
K
G
E
I
C
V
A
G
T
R
-
I
Y
V
Q
E
G
I
Y
D
E
F
V
K
K
A
A
E
L
A
S
K
S
V
V
G
D
P
F
-
N
P
S
V
S
Q
G
P
Q
V
D
K
D
Q
Y
E
K
V
L
R
Y
I
D
I
G
K
R
E
G
A
T
L
V
T
G
G
K
P
---
C
----
G
D
K
-----
G
Y
Y
I
E
P
T
I
F
T
D
V
K
D
D
M
T
I
A
Q
D
E
I
F
G
P
V
M
A
L
M
K
F
K
--
T
V
E
E
V
I
Q
K
A
N
N
T
R
Y
G
L
A
A
G
I
V
T
K
N
I
D
V
A
N
T
V
S
--
R
S
I
R
A
G
A
I
W
I
N
C
-
Y
F
A
-
F
D
P
D
A
P
F
G
G
Y
K
M
S
G
F
G
-
K
D
--
M
G
M
D
A
L
D
K
Y
L
Q
T
K
T
V
V
T
P
L
Y
-----
126
HHSearch
74.09
31%
-91
- C4 -
4NM9
10
?
A:
[509-995]
----
K
T
Y
P
L
F
I
N
G
K
E
V
R
T
--
N
-
D
L
I
P
T
V
N
P
N
K
P
S
E
V
L
G
Q
I
C
Q
A
G
T
T
E
V
G
D
A
I
A
A
A
K
A
A
F
P
--
A
--
W
R
D
T
D
P
R
T
R
A
E
Y
L
L
K
A
A
Q
A
A
R
K
R
L
F
E
L
S
A
W
Q
V
L
E
I
G
K
Q
W
D
Q
A
Y
-
A
-
D
-
V
T
E
A
I
D
F
L
E
Y
Y
A
R
E
M
I
R
L
G
Q
P
Q
R
V
G
H
A
P
G
E
L
N
H
Y
F
------
Y
E
P
K
G
V
A
A
V
I
A
P
W
N
F
P
L
A
I
S
M
G
M
A
S
A
A
I
V
T
G
N
C
V
V
F
K
P
S
G
I
T
S
I
I
G
W
H
L
V
E
L
----
F
R
E
A
G
L
P
E
G
V
F
N
F
T
P
G
R
G
S
V
M
G
D
Y
L
V
-
D
H
P
D
I
S
L
I
A
F
T
G
S
M
E
T
G
L
R
I
I
E
R
A
A
-
K
VHPGQA
N
V
K
K
I
I
S
E
M
G
G
K
N
A
I
I
I
D
D
D
A
D
L
D
E
A
V
P
H
V
L
Y
S
A
F
G
F
Q
G
Q
K
C
S
A
C
S
R
-
V
I
V
L
D
A
V
Y
D
K
F
I
E
R
L
V
S
M
A
K
A
T
K
V
G
P
S
E
-
D
P
A
N
Y
M
G
A
V
A
D
D
K
A
M
K
S
I
K
E
Y
A
E
I
G
K
R
E
G
H
-
V
L
Y
E
S
P
V
---
P
----
A
G
E
-----
G
Y
F
V
P
M
T
I
I
G
G
I
K
P
E
H
R
I
A
Q
E
E
I
F
G
P
V
L
A
V
M
R
A
K
--
D
F
D
Q
A
I
E
W
A
N
S
T
Q
F
A
L
T
G
G
I
F
S
R
S
P
E
H
L
A
K
A
R
--
R
E
F
R
V
G
N
L
Y
I
N
R
N
N
T
G
A
L
V
E
R
Q
P
F
G
G
A
R
M
S
G
V
G
-
T
K
-
A
G
G
P
D
Y
L
L
H
F
M
D
P
R
V
V
T
E
N
T
M
R
R
G
F
A
3
PsiBlast_PDB
73.80
41%
-90
- C4 -
4E4G
-
?
A:
[1-482]
-----
E
L
G
H
F
I
D
G
K
R
V
A
G
T
S
G
-
R
V
S
N
I
F
N
P
A
T
-
G
E
V
Q
G
T
V
A
L
A
S
D
A
D
L
A
A
A
V
E
S
A
K
A
A
Q
P
--
K
--
W
A
A
T
N
P
Q
R
R
A
R
V
F
M
K
F
V
Q
L
L
N
D
N
M
N
E
L
A
E
M
L
S
R
E
H
G
K
T
I
D
D
A
K
-
G
-
D
-
I
V
R
G
L
E
V
C
E
F
V
I
G
I
P
H
L
Q
K
S
E
F
T
E
G
A
G
P
G
I
D
M
Y
S
I
------
R
Q
P
V
G
I
G
A
G
I
T
P
F
N
F
P
G
M
I
P
M
W
M
F
A
P
A
I
A
C
G
N
A
F
I
L
K
P
S
E
R
D
P
S
V
P
I
R
L
A
E
L
----
M
I
E
A
G
L
P
A
G
I
L
N
V
V
N
G
-
D
K
G
A
V
D
A
I
L
-
T
H
P
D
I
A
A
V
S
F
V
G
S
T
P
I
A
R
Y
V
Y
G
T
A
A
-
M
------
N
G
K
R
A
Q
C
F
G
G
A
K
N
H
M
I
I
M
P
D
A
D
L
D
Q
A
A
N
A
L
I
G
A
G
Y
G
S
A
G
E
R
C
M
A
I
S
V
A
V
P
V
G
E
E
T
A
N
R
L
I
D
K
L
V
P
M
V
E
S
L
R
I
G
P
Y
T
-
D
E
K
A
D
M
G
P
V
V
T
K
E
A
E
Q
R
I
R
S
L
I
D
S
G
I
E
Q
G
A
K
L
V
V
D
G
R
D
FKL
Q
G
---
Y
E
N
-----
G
H
F
I
G
G
C
L
F
D
D
V
T
P
D
M
D
I
Y
K
T
E
I
F
G
P
V
L
S
V
V
R
A
R
--
N
Y
E
E
A
L
S
L
P
M
K
H
E
Y
G
N
G
V
A
I
Y
T
R
D
G
D
A
A
R
D
F
A
--
S
R
I
N
I
G
M
V
G
V
N
V
P
I
P
V
-
P
L
A
Y
H
S
F
G
G
W
K
S
S
S
F
G
D
L
N
-
Q
H
G
T
D
S
I
K
F
W
T
R
T
K
T
I
T
S
R
W
P
S
----
123
HHSearch
72.68
28%
-92
- C4 -
4PXN
1
?
A:
[36-514]
----
R
N
P
G
A
F
A
C
G
A
W
G
G
S
--
G
-
P
T
V
T
S
T
S
P
T
N
-
N
Q
V
I
A
E
V
V
E
A
S
V
H
D
Y
E
E
G
M
R
A
C
F
D
A
A
K
--
T
--
W
M
A
I
P
A
P
K
R
G
E
I
V
R
Q
I
G
D
A
L
R
A
K
L
H
H
L
G
R
L
V
S
L
E
M
G
K
I
L
P
E
G
I
-
G
-
E
-
V
Q
E
I
I
D
M
C
D
Y
A
V
G
L
S
R
Q
L
N
G
S
I
I
P
S
E
R
P
N
H
M
M
M
E
V
------
W
N
P
L
G
V
V
G
V
I
T
A
F
N
F
P
C
A
V
L
G
W
N
A
C
I
A
L
V
C
G
N
C
V
V
W
K
G
A
P
T
T
P
L
I
T
I
A
M
T
K
I
V
A
S
V
L
E
K
N
N
L
P
G
A
I
F
T
S
F
C
G
-
G
T
E
I
G
Q
A
I
A
-
L
D
I
R
I
P
L
V
S
F
T
G
S
T
R
A
G
L
M
V
Q
Q
Q
V
S
-
A
------
R
F
G
K
C
L
L
E
L
S
G
N
N
A
I
I
V
M
D
D
A
D
I
Q
L
A
V
R
S
V
L
F
A
A
V
G
T
A
G
Q
R
C
T
T
C
R
R
-
L
I
L
H
E
N
I
Y
Q
T
F
L
D
Q
L
V
E
V
Y
K
Q
V
R
I
G
D
P
L
-
E
K
G
T
L
L
G
P
L
H
T
P
A
S
K
E
N
F
L
K
G
I
Q
T
I
K
S
Q
G
G
K
I
L
F
G
G
S
A
---
I
----
E
S
E
-----
G
N
F
V
Q
P
T
I
V
E
-
I
T
P
S
A
P
V
V
K
E
E
L
F
G
P
V
L
Y
V
M
K
F
Q
--
T
L
K
E
A
I
E
I
N
N
S
V
P
Q
G
L
S
S
S
I
F
T
K
R
P
D
I
I
F
K
W
L
GP
H
G
S
D
C
G
I
V
N
V
N
I
P
T
N
G
-
A
E
I
G
G
A
F
G
G
E
K
A
T
G
G
G
-
R
E
--
A
G
S
D
S
W
K
Q
Y
M
R
R
A
T
C
T
I
N
Y
G
S
----
117
HHSearch
72.55
33%
-84
- C4 -
4PZ2
6
?
A:
[50-531]
-----
F
T
K
L
F
I
N
G
S
F
V
D
A
V
S
G
-
R
T
F
D
T
R
D
P
R
T
-
G
G
V
I
A
S
V
A
E
A
D
K
E
D
V
D
L
A
V
R
A
A
R
A
A
F
D
HG
E
--
W
P
R
M
S
G
S
E
R
G
R
I
M
A
R
L
A
D
L
V
E
E
H
A
G
E
L
A
A
L
E
S
L
D
A
G
K
H
P
A
V
T
R
A
V
-
D
-
V
G
N
A
A
G
S
L
R
Y
F
A
G
A
A
D
K
I
H
G
E
T
L
K
-
M
P
G
Q
F
Q
G
H
T
L
------
R
E
P
L
G
V
A
G
V
I
I
P
W
N
F
P
S
T
M
F
A
V
K
V
A
P
A
L
A
A
G
C
A
L
V
V
K
P
A
E
Q
T
P
L
S
A
L
Y
L
A
Q
L
----
A
K
Q
A
G
V
P
D
G
V
I
N
V
V
P
G
F
G
P
T
A
G
A
A
L
A
-
S
H
M
D
V
D
M
V
S
F
T
G
S
T
E
V
G
R
L
I
M
K
A
S
A
E
S
------
N
L
K
P
V
Y
L
E
L
G
G
K
S
P
L
I
V
F
D
D
A
D
L
D
M
A
V
E
L
A
V
G
A
S
F
F
N
K
G
E
A
C
V
A
A
S
R
-
V
Y
V
Q
E
R
V
Y
D
R
F
E
E
R
L
A
E
R
M
R
S
W
V
V
G
D
P
F
S
D
P
R
A
D
Q
G
P
Q
V
D
K
A
Q
Y
E
R
V
L
S
Y
I
D
H
G
K
R
E
G
A
T
L
L
T
G
G
R
P
---
C
A
P----
K
-----
G
Y
Y
I
E
P
T
V
F
T
N
V
K
E
D
M
I
I
A
K
E
E
I
F
G
P
V
M
C
L
M
K
F
K
--
T
V
E
E
A
I
A
R
A
N
D
T
R
Y
G
L
G
A
G
V
V
T
R
D
L
D
V
A
N
R
V
V
--
R
S
V
R
A
G
V
V
W
V
N
C
-
Y
F
A
-
M
G
S
D
C
P
F
G
G
R
K
M
S
G
F
G
-
K
D
--
E
G
M
H
A
L
D
K
Y
L
A
V
K
S
V
V
T
P
L
R
A
S
---
52
PsiBlast_CBE
71.99
32%
-86
- C4 -
3RHJ
15
AL1L1_RAT
B:
[40-517]
---------
F
I
G
G
E
F
V
D
A
E
G
S
-
K
T
Y
N
T
I
N
P
T
D
-
G
S
V
I
C
Q
V
S
L
A
Q
V
S
D
V
D
K
A
V
A
A
A
K
E
A
F
E
--
N
GL
W
G
K
I
N
A
R
D
R
G
R
L
L
Y
R
L
A
D
V
M
E
Q
H
Q
E
E
L
A
T
I
E
A
L
D
A
G
A
V
Y
T
L
A
L
-
K
T
H
-
V
G
M
S
I
Q
T
F
R
Y
F
A
G
W
C
D
K
I
Q
G
---
A
T
I
P
I
N
Q
A
R
P
N
R
NLTLTK
K
E
P
V
G
V
C
G
I
V
I
P
W
N
Y
P
L
M
M
L
S
W
K
T
A
A
C
L
A
A
G
N
T
V
V
I
K
P
A
Q
V
T
P
L
T
A
L
K
F
A
E
L
----
T
L
K
A
G
I
P
K
G
V
V
N
I
L
P
G
-
S
G
S
L
V
G
Q
R
L
S
D
H
P
D
V
R
K
I
G
F
T
G
S
T
E
V
G
K
H
I
M
K
S
C
A
L
S
------
N
V
K
K
V
S
L
A
L
G
G
K
S
P
L
I
I
F
A
D
C
D
L
N
K
A
V
Q
M
G
M
S
S
V
F
F
N
K
G
E
N
C
I
A
A
G
R
-
L
F
V
E
E
S
I
H
N
Q
F
V
Q
K
V
V
E
E
V
E
K
M
K
I
G
N
P
L
-
E
R
D
T
N
H
G
P
Q
N
H
E
A
H
L
R
K
L
V
E
Y
C
Q
R
G
V
K
E
G
A
T
L
V
C
G
G
N
Q
----
V
---
P
R
P
-----
G
F
F
F
Q
P
T
V
F
T
D
V
E
D
H
M
Y
I
A
K
E
E
S
F
G
P
I
M
I
I
S
R
F
A
DG
D
V
D
A
V
L
S
R
A
N
A
T
E
F
G
L
A
S
G
V
F
T
R
D
I
N
K
A
L
Y
V
S
--
D
K
L
Q
A
G
T
V
F
I
N
T
Y
N
K
T
-
D
V
A
-
A
P
F
G
G
F
K
Q
S
G
F
G
--
K
-
D
L
G
E
A
A
L
N
E
Y
L
R
I
K
T
V
T
F
E
Y
------
43
PsiBlast_CBE
71.68
33%
-77
- C4 -
4QF6
3
?
E:
[18-489]
----
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
-
K
T
F
E
T
Y
N
P
A
T
-
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
E
--
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
L
-
D
-
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
G
W
T
T
K
I
I
G
Q
T
I
-
P
I
S
K
D
Y
L
N
Y
T
R
------
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
----
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
-
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
A
-
E
------
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
-
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
-
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
-
V
A
A
G
G
E
---
R
A
---
L
E
K
-----
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
--
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
--
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
-
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
--
R
-
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
----------
100
PsiBlast_CBE
71.67
31%
-88
- C4 -
1BPW
1
BADH_GADMC
C:
[22-492]
--------
N
Y
W
G
G
R
R
I
K
S
K
D
G
A
T
T
E
P
V
F
E
P
A
T
-
G
R
V
L
C
Q
M
V
P
C
G
A
E
E
V
D
Q
A
V
Q
S
A
Q
A
A
Y
L
--
K
--
W
S
K
M
A
G
I
E
R
S
R
V
M
L
E
A
A
R
I
I
R
E
R
R
D
N
I
A
K
L
E
V
I
N
N
G
K
T
I
T
E
A
E
-
Y
-
D
-
I
D
A
A
W
Q
C
I
E
Y
Y
A
G
L
A
P
T
L
S
G
Q
H
I
-
Q
L
P
G
G
A
F
A
Y
T
R
------
R
E
P
L
G
V
C
A
G
I
L
A
W
N
Y
P
F
M
I
A
A
W
K
C
A
P
A
L
A
C
G
N
A
V
V
F
K
P
S
P
M
T
P
V
T
G
V
I
L
A
E
I
----
F
H
E
A
G
V
P
V
G
L
V
N
V
V
Q
G
-
G
A
E
T
G
S
L
L
C
-
H
H
P
N
V
A
K
V
S
F
T
G
S
V
P
T
G
K
K
V
M
E
M
S
A
-
K
------
T
V
K
H
V
T
L
E
L
G
G
K
S
P
L
L
I
F
K
D
C
E
L
E
N
A
V
R
G
A
L
M
A
N
F
L
T
Q
G
Q
V
C
T
N
G
T
R
-
V
F
V
Q
R
E
I
M
P
Q
F
L
E
E
V
V
K
R
T
K
A
I
V
V
G
D
P
L
-
L
T
E
T
R
M
G
G
L
I
S
K
P
Q
L
D
K
V
L
G
F
V
A
Q
A
K
K
E
G
A
R
V
L
C
G
G
E
P
---
L
T
---
P
S
D
PKLKN
G
Y
F
M
S
P
C
V
L
D
N
C
R
D
D
M
T
C
V
K
E
E
I
F
G
P
V
M
S
V
L
P
F
D
--
T
E
E
E
V
L
Q
R
A
N
N
T
T
F
G
L
A
S
G
V
F
T
R
D
I
S
R
A
H
R
V
A
--
A
N
L
E
A
G
T
C
Y
I
N
T
Y
S
I
S
-
P
V
E
-
V
P
F
G
G
Y
K
M
S
G
F
G
--
R
-
E
N
G
Q
A
T
V
D
Y
Y
S
Q
L
K
T
V
----------
99
PsiBlast_CBE
71.56
31%
-88
- C4 -
1BPW
1
BADH_GADMC
D:
[22-492]
--------
N
Y
W
G
G
R
R
I
K
S
K
D
G
A
T
T
E
P
V
F
E
P
A
T
-
G
R
V
L
C
Q
M
V
P
C
G
A
E
E
V
D
Q
A
V
Q
S
A
Q
A
A
Y
L
--
K
--
W
S
K
M
A
G
I
E
R
S
R
V
M
L
E
A
A
R
I
I
R
E
R
R
D
N
I
A
K
L
E
V
I
N
N
G
K
T
I
T
E
A
E
-
Y
-
D
-
I
D
A
A
W
Q
C
I
E
Y
Y
A
G
L
A
P
T
L
S
G
Q
H
I
-
Q
L
P
G
G
A
F
A
Y
T
R
------
R
E
P
L
G
V
C
A
G
I
L
A
W
N
Y
P
F
M
I
A
A
W
K
C
A
P
A
L
A
C
G
N
A
V
V
F
K
P
S
P
M
T
P
V
T
G
V
I
L
A
E
I
----
F
H
E
A
G
V
P
V
G
L
V
N
V
V
Q
G
-
G
A
E
T
G
S
L
L
C
-
H
H
P
N
V
A
K
V
S
F
T
G
S
V
P
T
G
K
K
V
M
E
M
S
A
-
K
------
T
V
K
H
V
T
L
E
L
G
G
K
S
P
L
L
I
F
K
D
C
E
L
E
N
A
V
R
G
A
L
M
A
N
F
L
T
Q
G
Q
V
C
T
N
G
T
R
-
V
F
V
Q
R
E
I
M
P
Q
F
L
E
E
V
V
K
R
T
K
A
I
V
V
G
D
P
L
-
L
T
E
T
R
M
G
G
L
I
S
K
P
Q
L
D
K
V
L
G
F
V
A
Q
A
K
K
E
G
A
R
V
L
C
G
G
E
P
---
L
T
---
P
S
D
PKLKN
G
Y
F
M
S
P
C
V
L
D
N
C
R
D
D
M
T
C
V
K
E
E
I
F
G
P
V
M
S
V
L
P
F
D
--
T
E
E
E
V
L
Q
R
A
N
N
T
T
F
G
L
A
S
G
V
F
T
R
D
I
S
R
A
H
R
V
A
--
A
N
L
E
A
G
T
C
Y
I
N
T
Y
S
I
S
-
P
V
E
-
V
P
F
G
G
Y
K
M
S
G
F
G
--
R
-
E
N
G
Q
A
T
V
D
Y
Y
S
Q
L
K
T
V
----------
37
PsiBlast_CBE
71.49
33%
-79
- C4 -
4QF6
5
?
K:
[18-489]
----
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
-
K
T
F
E
T
Y
N
P
A
T
-
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
E
--
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
L
-
D
-
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
G
W
T
T
K
I
I
G
Q
T
I
-
P
I
S
K
D
Y
L
N
Y
T
R
------
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
----
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
-
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
A
-
E
------
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
-
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
-
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
-
V
A
A
G
G
E
---
R
A
---
L
E
K
-----
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
--
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
--
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
-
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
--
R
-
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
----------
28
PsiBlast_CBE
71.42
34%
-77
- C4 -
4PT0
1
?
C:
[18-489]
----
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
-
K
T
F
E
T
Y
N
P
A
T
-
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
E
--
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
L
-
D
-
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
G
W
T
T
K
I
I
G
Q
T
I
-
P
I
S
K
D
Y
L
N
Y
T
R
------
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
E
Q
T
P
L
S
L
L
Y
A
A
K
L
----
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
-
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
A
-
E
------
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
-
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
-
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
-
V
A
A
G
G
E
---
R
A
---
L
E
K
-----
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
--
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
--
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
-
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
--
R
-
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
----------
41
PsiBlast_CBE
71.35
33%
-77
- C4 -
4QF6
2
?
G:
[18-489]
----
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
-
K
T
F
E
T
Y
N
P
A
T
-
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
E
--
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
L
-
D
-
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
G
W
T
T
K
I
I
G
Q
T
I
-
P
I
S
K
D
Y
L
N
Y
T
R
------
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
----
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
-
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
A
-
E
------
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
-
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
-
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
-
V
A
A
G
G
E
---
R
A
---
L
E
K
-----
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
--
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
--
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
-
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
--
R
-
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
----------