@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu05370: (2016-06-08 )
MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLAKDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQMPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKGYLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYSLHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRREEILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIGWIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELALSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKGNYIRLSYAYASLEDLQKGIYELGLMIKELASR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140....-...--150.--........160.......170-..-.....180.......190.......200.......210.......220.......230.......----240...-..------..-----250..-.....260.......270.......280.......290.......300..-.....310---....--...320.......330.......340.......350.......360.......370...-....380.......390.......400........410.......420.......430.-....-..440-...--.-...--450........460.......470.......480
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSF
P
E
E
K
K
M
K
K
L
P
K
Y
R
Q
I
V
H
F
I
K
E
KIGNGEWPIGSKIPS
Q
R
T
L
A
K
D
FQV
N
R
S
T
V
I
T
A
L
E
E
L
M
A
D
GLIEGTMGK
G
T
V
V
INN
T
W
T
L
M
AKNSAP
D
W
D
Q
Y
V
T
SGIQM
P
S
R
K
I
V
Q
E
I
N
QSESNT
D
L
I
Q
LSKGELSAEI
F
P
L
A
V
M
K
E
M
M
G
K
V
-
S
Q
H
--
M
--
E
--
A
FGYEEPKGY
L
P
L
R
E
A
L
S
N
Y
L
-
K
T
-
I
G
INVSS
S
S
I
L
I
V
S
G
A
L
Q
A
L
Q
L
I
S
M
G
L
LQRG
S
T
V
Y
LDQP
S
Y
L
Y
S
L
H
V
F
Q
SAG
M
K
L
TGLPMDNEGL----LPEN
V
H
-LT------RG-----ERG
R
A
-
I
L
YTNPCFHNP
T
G
I
L
M
S
K
KR
R
E
E
I
L
AVSENTQLPII
E
D
D
I
Y
R
E
L
W
IDEIP-PYP
I
K
T
ID---KNG
H
--
V
L
Y
IG
S
L
S
KTLSPG
L
R
I
G
W
I
VG
P
E
P
V
I
E
R
L
S
D
I
K
M
QTDYGS
S
S
L
S
Q
R
V
A
A
E
W
F
TS
G
H
Y
Q
-
Q
H
V
E
K
V
R
Q
Q
L
K
V
R
R
E
L
A
L
S
A
L
E
T
H
L
K
-
E
V
ATWNIPKG
G
F
F
V
W
I
K
ILPS
I
S
M
K
L
L
Y
T
K
AL-SK
G
I
-
L
I
N
L
G
-
S
I
Y
--
A
-QEK--G-
N
Y
I
R
L
S
Y
A
YA
S
L
E
D
L
Q
K
G
I
Y
E
L
G
L
M
I
K
E
L
ASR
1
PsiBlast_PDB
73.06
32%
-116
- C1 -
1X0M
-
?
A:
[46-424]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
A
D
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
5
PsiBlast_PDB
72.44
32%
-115
- C1 -
3AV7
5
?
A:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
A
D
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
23
PsiBlast_CBE
72.04
32%
-112
- C1 -
3ATH
5
?
C:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
AD
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
KVEI
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
4
PsiBlast_PDB
71.95
32%
-110
- C1 -
3ATH
5
?
A:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
A
D
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
3
PsiBlast_PDB
71.88
32%
-112
- C1 -
3AOW
4
?
A:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
A
D
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
2
PsiBlast_PDB
71.78
32%
-112
- C1 -
3AOV
2
?
A:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
A
D
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
25
PsiBlast_CBE
71.67
32%
-111
- C1 -
3AOV
2
?
C:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
AD
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
KVEI
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
22
PsiBlast_CBE
71.53
32%
-112
- C1 -
3AV7
4
?
C:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
AD
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
KVEI
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
24
PsiBlast_CBE
71.32
32%
-111
- C1 -
3AOW
4
?
C:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
AD
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
KVEI
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
21
PsiBlast_CBE
71.24
32%
-112
- C1 -
3WX9
7
?
C:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
AD
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
KVEI
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
6
PsiBlast_PDB
71.04
32%
-113
- C1 -
3WX9
7
?
A:
[66-444]
------------------------------------------------------------------------------------------------------------
V
R
E
L
L
K
L
V
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
--
Y
A
D
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
-
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
-
E
L
------
K
S
-----
Q
G
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
E
A
F
Y
--
A
H
R
D
V
--
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
----
7
PsiBlast_PDB
68.92
30%
-109
- C1 -
1WST
1
?
A:
[14-414]
-------------------------------------------------------------------------------------------
N
F
D
S
F
F
S
E
K
A
M
L
M
K
A
S
E
V
R
E
L
L
K
L
V
E
T
S
D
V
I
S
L
A
G
G
L
P
A
P
E
T
F
P
V
E
T
I
K
K
I
A
V
E
V
L
E
E
H
--
A
--
D
K
-
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
L
A
L
A
R
W
M
E
K
R
-
Y
D
I
P
M
S
K
V
E
I
M
T
V
A
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
P
I
V
V
E
A
P
T
Y
L
A
A
I
Q
A
F
K
Y
Y
D
P
E
F
I
S
I
P
L
D
D
K
G
M
----
R
V
D
L
L
E
-
E
K
L
E
E
L
R
K
Q
G
-----
K
R
V
K
--
I
V
Y
T
V
S
T
F
Q
N
P
A
G
V
T
M
S
V
D
R
R
K
K
L
L
E
L
A
N
E
Y
D
F
L
I
V
E
D
G
P
Y
S
E
L
R
Y
S
G
E
P
-
T
P
P
I
K
H
F
D
---
D
Y
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
V
A
A
H
P
H
L
I
R
K
M
E
I
A
K
Q
S
I
D
L
C
T
N
T
F
G
Q
A
I
A
W
K
Y
V
E
N
G
Y
L
D
-
E
H
I
P
K
I
I
E
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
Y
M
P
-
E
G
V
E
W
T
K
P
E
G
G
M
F
V
R
V
T
L
P
E
G
I
D
T
K
L
M
M
E
R
A
V
-
A
K
G
V
-
A
Y
V
P
G
-
E
A
F
FV
H
-
R
D
K
--
K
-
N
T
M
R
L
N
F
T
Y
V
P
E
E
T
I
R
E
G
V
R
R
L
A
E
T
I
K
E
E
M
K
R
62
HHSearch
68.50
32%
-108
- C1 -
3AOW
4
?
A:
[75-446]
---------------------------------------------------------------------------------------------------------------------
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
-
M
E
K
Y
A
D
--
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
K
R
Y
G
I
S
Q
-
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
----
K
V
E
I
L
E
E
K
L
------
K
E
L
K
S
Q
G
K
-
K
V
K
-
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
K
A
L
D
---
N
E
G
R
--
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
G
V
-
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
-
A
Y
V
P
G
-
E
A
F
--
Y
-
A
H
R
DV
K
-
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
E
L
--
10
PsiBlast_PDB
68.11
29%
-116
- C1 -
2ZP7
3
LYSN_THET2
C:
[5-393]
-------------------------------------------------------------------------------------------
S
W
S
E
A
F
G
K
G
A
G
R
I
Q
A
S
T
I
R
E
L
L
K
L
T
Q
R
P
G
I
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
-
L
R
E
--
K
--
G
EV
A
L
Q
Y
S
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
-------
I
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D---
L
D
A
L
E
E
-
V
L
------
K
R
-----
E
R
P
R
--
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
R
---
E
A
G
Y
PG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
-
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
E
N
V
A
F
V
P
G
G
-
P
F
F
--
A
-
N
G
G
--
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
---
13
PsiBlast_PDB
68.07
29%
-113
- C1 -
2ZYJ
2
LYSN_THET2
A:
[5-393]
-------------------------------------------------------------------------------------------
S
W
S
E
A
F
G
K
G
A
G
R
I
Q
A
S
T
I
R
E
L
L
K
L
T
Q
R
P
G
I
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
-
L
R
E
--
K
--
G
E
V
A
L
Q
Y
S
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
-------
I
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D---
L
D
A
L
E
E
-
V
L
------
K
R
-----
E
R
P
R
--
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
R
---
E
A
G
Y
PG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
-
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
E
N
V
A
F
V
P
G
G
-
P
F
F
--
A
-
N
G
G
--
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
---
67
HHSearch
67.19
30%
-118
- C1 -
2ZYJ
2
LYSN_THET2
A:
[31-395]
---------------------------------------------------------------------------------------------------------------------
R
P
G
I
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
-
L
R
E
K
G
E
--
V
--
A
L
Q
Y
S
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
I
-----
G
--
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
----
D
L
D
A
L
E
E
V
L
------
K
R
-----
E
-
R
P
R
-
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
-
L
P
S
L
F
E
L
A
R
E
A
G
Y
P
G
--
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
E
V
-
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
E
N
V
-
A
F
V
P
G
-
G
P
F
--
F
-
A
N
G
GG
E
-
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
L
A
-
11
PsiBlast_PDB
67.06
29%
-112
- C1 -
3CBF
2
LYSN_THET2
A:
[5-393]
-------------------------------------------------------------------------------------------
S
W
S
E
A
F
G
K
G
A
G
R
I
Q
A
S
T
I
R
E
L
L
K
L
T
Q
R
P
G
I
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
-
L
R
E
--
K
--
G
E
V
A
L
Q
Y
S
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
-------
I
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D---
L
D
A
L
E
E
-
V
L
------
K
R
-----
E
R
P
R
--
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
R
---
E
A
G
Y
PG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
-
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
E
N
V
A
F
V
P
G
G
-
P
F
F
--
A
-
N
G
G
--
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
---
12
PsiBlast_PDB
67.03
29%
-110
- C1 -
2Z1Y
2
LYSN_THET2
A:
[5-393]
-------------------------------------------------------------------------------------------
S
W
S
E
A
F
G
K
G
A
G
R
I
Q
A
S
T
I
R
E
L
L
K
-----
G
I
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
-
L
R
E
--
K
--
G
E
V
A
L
Q
Y
S
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
-------
I
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D---
L
D
A
L
E
E
-
V
L
------
K
R
-----
E
R
P
R
--
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
R
---
E
A
G
Y
PG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
-
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
E
N
V
A
F
V
P
G
G
-
P
F
F
--
A
-
N
G
G
--
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
---
9
PsiBlast_PDB
64.74
29%
-105
- C1 -
2EGY
2
LYSN_THET2
A:
[5-393]
-------------------------------------------------------------------------------------------
S
W
S
E
A
F
G
K
G
A
G
R
I
Q
A
S
T
I
R
E
L
L
K
L
T
Q
R
P
G
I
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
-
L
R
E
--
K
--
G
E
V
A
L
Q
Y
S
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
-------
I
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D---
L
D
A
L
E
E
-
V
L
------
K
R
-----
E
R
P
R
--
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
R
---
E
A
G
Y
PG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
-
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
E
N
V
A
F
V
P
G
G
-
P
F
F
--
A
-
N
G
G
--
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
---
65
HHSearch
64.63
30%
-115
- C1 -
2ZC0
4
?
A:
[33-405]
---------------------------------------------------------------------------------------------------------------------
G
V
K
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
-
L
E
K
E
-
P
--
K
--
S
V
M
Y
T
P
A
N
G
I
P
E
L
R
E
E
L
A
A
F
L
-
K
K
Y
D
H
L
E
V
S
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
M
----
R
V
D
L
L
E
E
K
I
------
K
E
L
K
A
K
G
Q
-
K
V
K
-
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
Y
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
-
I
V
P
L
K
A
L
D
---
N
E
G
R
--
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
F
E
K
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
-
N
A
-
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
A
D
G
I
S
F
A
N
E
L
M
E
R
E
G
V
-
V
V
V
P
G
-
K
P
F
--
Y
-
T
D
E
SG
K
-
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
P
I
G
I
K
K
L
A
K
L
Y
K
E
K
F
--