@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu05490: (2016-06-08 )
MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPGTYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFNVPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLSEQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHIAWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHDETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD
Atome Classification :
(20 SA)
-------------.........10...--.....20........30........40.-.-..-....50.......-.60.....-..-.70------.--.......80......-..90........100.....-.-----.-----110-....-.....120-.......---130...-.--------..-.140-----.--------.-----------.-....-----------..150.......160--.......170.......180---------.---------.---------.---------------....-190.--..-.....200..------..---.------.---.210.......220.......230....--...240.-.-.-..--.--.----------------------250---.......-260........270...-...-----.280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MAKKTM
G
I
H
H
I
T
A
I
--VGHPQENT
D
F
Y
A
G
V
L
G
L
R
L
V
K
Q
TVNFDD-P-
G
T
-
Y
H
L
Y
FGNEGGKP
G
-
T
I
I
T
F
FPW-AG-ARQ------G--VIGDGQVG
V
T
S
Y
VVP-
K
G
A
M
A
F
W
E
K
R
L
E
KFNV
P
Y
T
K
-
I
-----
E
-----
R
---
F
G
E
Q
-YVEFDDPH-
G
L
H
L
E
I
V
---
E
REEGE-A--------N
T
-
W
T
-------F--------G-----------E-VTP
D
-----------
V
A
I
KGFGGATLLSEQ--PD
K
T
A
D
L
L
E
N
I
M
G
L
E
R
VGKE---------G---------
D
---------
F
---------------
V
R
Y
R-S-AG--DI-G
N
V
I
D
L
K
L
T
P------IG---R------G---QMGAG
T
V
H
H
I
A
W
RANDDE
D
Q
L
D
W
Q
R
Y
I
A
--SHGYGVT-P-V-RD--R--N----------------------Y
F
N
---
A
I
Y
F
REH-
G
E
-
I
L
F
E
IATDPPGFAH-
D
E
T
-----
Q
E
T
MGE
K
L
M
L
P
VQYEP
H
R
T
Q
I
E
QGLLP
F
E
V
RELD
21
PsiBlast_CBE
86.06
100%
-78
- C2 -
3OAJ
2
MHQO_BACSU
B:
[3-312]
--------------
A
K
K
T
M
G
I
H
H
I
T
A
I
--
V
G
H
P
Q
E
N
T
D
F
Y
A
G
V
L
G
L
R
L
V
K
Q
T
V
N
F
D
D
-
P
-
G
T
-
Y
H
L
Y
F
G
N
E
G
G
K
P
G
-
T
I
I
T
F
F
P
W
-
A
G
-
A
R
Q
------
G
--
V
I
G
D
G
Q
V
G
V
T
S
Y
V
V
P
-
K
G
A
M
A
F
W
E
K
R
L
E
K
F
N
V
P
Y
T
K
-
I
-----
E
-----
R
---
F
G
E
Q
-
Y
V
E
F
D
D
P
H
-
G
L
H
L
E
I
V
---
E
R
E
E
G
E
-
A
--------
N
T
-
W
T
-------
F
--------
G
-----------
E
-
V
T
P
D
-----------
V
A
I
K
G
F
G
G
A
T
L
L
S
E
Q
--
P
D
K
T
A
D
L
L
E
N
I
M
G
L
E
R
V
G
K
E
---------
G
---------
D
---------
F
---------------
V
R
Y
R
-
S
-
A
G
--
D
I
-
G
N
V
I
D
L
K
L
T
P
------
I
G
---
R
------
G
---
Q
M
G
A
G
T
V
H
H
I
A
W
R
A
N
D
D
E
D
Q
L
D
W
Q
R
Y
I
A
--
S
H
G
Y
G
V
T
-
P
-
V
-
R
D
--
R
--
N
----------------------
Y
F
N
---
A
I
Y
F
R
E
H
-
G
E
-
I
L
F
E
I
A
T
D
P
P
G
F
A
H
-
D
E
T
-----
Q
E
T
M
G
E
K
L
M
L
P
V
Q
Y
E
P
H
R
T
Q
I
E
Q
G
L
L
P
F
E
V
R
E
L
-
1
PsiBlast_PDB
84.63
100%
-76
- C2 -
3OAJ
2
MHQO_BACSU
A:
[3-312]
--------------
A
K
K
T
M
G
I
H
H
I
T
A
I
--
V
G
H
P
Q
E
N
T
D
F
Y
A
G
V
L
G
L
R
L
V
K
Q
T
V
N
F
D
D
-
P
-
G
T
-
Y
H
L
Y
F
G
N
E
G
G
K
P
G
-
T
I
I
T
F
F
P
W
-
A
G
-
A
R
Q
------
G
--
V
I
G
D
G
Q
V
G
V
T
S
Y
V
V
P
-
K
G
A
M
A
F
W
E
K
R
L
E
K
F
N
V
P
Y
T
K
-
I
-----
E
-----
R
---
F
G
E
Q
-
Y
V
E
F
D
D
P
H
-
G
L
H
L
E
I
V
---
E
R
E
E
G
E
-
A
--------
N
T
-
W
T
-------
F
--------
G
-----------
E
-
V
T
P
D
-----------
V
A
I
K
G
F
G
G
A
T
L
L
S
E
Q
--
P
D
K
T
A
D
L
L
E
N
I
M
G
L
E
R
V
G
K
E
---------
G
---------
D
---------
F
---------------
V
R
Y
R
-
S
-
A
G
--
D
I
-
G
N
V
I
D
L
K
L
T
P
------
I
G
---
R
------
G
---
Q
M
G
A
G
T
V
H
H
I
A
W
R
A
N
D
D
E
D
Q
L
D
W
Q
R
Y
I
A
--
S
H
G
Y
G
V
T
-
P
-
V
-
R
D
--
R
--
N
----------------------
Y
F
N
---
A
I
Y
F
R
E
H
-
G
E
-
I
L
F
E
I
A
T
D
P
P
G
F
A
H
-
D
E
T
-----
Q
E
T
M
G
E
K
L
M
L
P
V
Q
Y
E
P
H
R
T
Q
I
E
Q
G
L
L
P
F
E
V
R
E
L
-
22
HHSearch
81.17
96%
-72
- C2 -
3OAJ
2
MHQO_BACSU
A:
[3-312]
--------------
A
K
K
T
M
G
I
H
H
I
T
A
I
--
V
G
H
P
Q
E
N
T
D
F
Y
A
G
V
L
G
L
R
L
V
K
Q
T
V
N
F
D
D
-
P
-
G
T
-
Y
H
L
Y
F
G
N
E
G
G
K
P
G
-
T
I
I
T
F
F
P
W
-
A
G
-
A
R
Q
------
G
V
I
G
D
G
Q
V
G
V
T
S
Y
V
V
P
K
G
---
A
M
A
F
W
E
K
R
L
E
K
F
N
V
P
Y
T
K
-
I
-----
E
-----
R
---
F
G
E
Q
-
Y
V
E
F
D
D
P
H
-
G
L
H
L
E
I
V
---
E
R
E
E
G
E
-
A
--------
N
T
-
W
T
-------
F
--------
G
-----------
E
-
V
T
P
D
-----------
V
A
I
K
G
F
G
G
A
T
L
L
S
E
Q
--
P
D
K
T
A
D
L
L
E
N
I
M
G
L
E
R
V
G
K
E
---------
G
---------
D
---------
F
---------------
V
R
Y
R
-
S
-
A
G
--
D
I
-
G
N
V
I
D
L
K
L
T
P
------
I
G
---
R
------
G
---
Q
M
G
A
G
T
V
H
H
I
A
W
R
A
N
D
D
E
D
Q
L
D
W
Q
R
Y
I
A
--
S
H
G
Y
G
V
T
-
P
-
V
-
R
D
--
R
--
N
----------------------
Y
F
N
---
A
I
Y
F
R
E
H
-
G
E
-
I
L
F
E
I
A
T
D
P
P
G
F
A
H
-
D
E
T
-----
Q
E
T
M
G
E
K
L
M
L
P
V
Q
Y
E
P
H
R
T
Q
I
E
Q
G
L
L
P
F
E
V
R
E
L
-
24
HHSearch
62.77
32%
-74
- C2 -
4HUZ
2
?
A:
[3-315]
--------------
T
N
H
I
T
S
L
H
H
I
T
I
C
--
T
G
T
A
Q
G
D
I
D
F
F
V
K
V
M
G
Q
R
F
V
K
R
T
L
F
Y
D
G
S
I
-
P
I
-
Y
H
L
Y
F
A
D
E
L
G
T
P
G
-
T
V
M
T
T
F
P
T
-
R
R
T
G
Q
K
------
G
--
R
K
G
S
N
Q
F
T
V
C
T
Y
A
I
P
-
K
G
S
L
E
W
W
I
G
H
L
N
A
H
G
I
A
T
G
E
-
P
-----
G
T
----
R
---
F
G
Q
R
-
Y
V
G
F
Q
H
P
D
C
G
I
D
F
E
V
L
---
E
D
E
N
D
T
-
R
--------
Q
P
-
Y
D
-------
S
--------
P
-----------
Y
-
V
P
I
E
-----------
H
A
Q
R
G
F
H
S
W
T
A
S
V
R
E
--
L
E
D
M
D
F
F
M
E
N
C
W
N
F
E
K
I
G
E
E
---------
G
---------
N
---------
R
---------------
H
R
Y
R
-
V
-
K
G
TT
E
S
-
G
T
I
I
D
L
L
H
E
P
------
D
R
---
R
------
Q
GSW
T
I
A
E
G
I
I
H
H
G
A
F
A
V
P
D
M
D
I
Q
A
R
I
K
F
E
T
E
--
G
V
G
F
T
D
F
S
D
-
R
-
K
N
--
R
--
G
----------------------
Y
F
E
---
S
T
Y
V
R
T
P
-
G
G
-
V
M
F
E
A
T
-
H
S
L
G
F
T
H
-
D
E
D
-----
E
R
S
L
G
M
D
L
K
V
S
P
Q
F
D
D
K
K
H
L
I
E
Q
A
M
E
D
-------
2
PsiBlast_PDB
62.22
35%
-80
- C2 -
1ZSW
2
?
A:
[30-336]
-------------------
G
H
H
H
I
S
M
V
--
T
K
N
A
N
E
N
N
H
F
Y
K
N
V
L
G
L
R
R
V
K
M
T
V
N
Q
D
D
-
P
-
S
M
-
Y
H
L
F
Y
G
D
K
T
G
S
P
G
-
T
E
L
S
F
F
E
I
-
P
L
-
V
G
R
------
T
--
Y
R
G
T
N
A
I
T
R
I
G
L
L
V
P
S
E
D
S
L
H
Y
W
K
E
R
F
E
K
F
D
V
K
H
S
E
-
M
-----
T
-----
T
---
Y
A
N
R
P
A
L
Q
F
E
D
A
E
-
G
L
R
L
-
V
L
---
L
V
S
N
G
E
-
K
VEH
W
----
E
T
-
W
E
-------
K
--------
S
-----------
E
-
V
P
A
K
-----------
H
Q
I
Q
G
M
G
S
V
E
L
T
V
R
R
--
L
D
K
M
A
S
T
L
T
E
I
F
G
Y
T
E
V
S
R
N
---------
D
---------
Q
---------
E
---------------
A
I
F
Q
-
S
I
K
G
--
E
A
-
F
G
E
I
V
V
K
Y
L
D
------
G
P
---
T
------
E
---
K
P
G
R
G
S
I
H
H
L
A
I
R
V
K
N
D
A
E
L
A
Y
W
E
E
Q
V
K
--
Q
R
G
F
H
S
S
-
G
-
I
-
I
D
--
R
--
F
----------------------
Y
F
K
---
S
L
Y
F
R
E
S
-
N
G
-
I
L
F
E
I
A
T
D
G
P
G
F
T
V
-
D
G
D
-----
V
E
H
L
G
E
K
L
D
L
P
P
F
L
E
D
Q
R
A
E
I
E
A
N
L
A
P
I
E
-----
23
HHSearch
62.20
35%
-77
- C2 -
1ZSW
2
?
A:
[24-336]
-------------
A
M
Y
E
I
K
G
H
H
H
I
S
M
V
--
T
K
N
A
N
E
N
N
H
F
Y
K
N
V
L
G
L
R
R
V
K
M
T
V
N
Q
D
D
-
P
-
S
M
-
Y
H
L
F
Y
G
D
K
T
G
S
P
G
-
T
E
L
S
F
F
E
I
-
P
L
-
V
G
R
------
T
--
Y
R
G
T
N
A
I
T
R
I
G
L
L
V
P
S
E
D
S
L
H
Y
W
K
E
R
F
E
K
F
D
V
K
H
S
E
-
M
-----
T
T----
Y
---
A
N
R
P
-
A
L
Q
F
E
D
A
E
-
G
L
R
L
V
L
L
---
V
S
N
G
E
K
-
V
EH
W
-----
E
T
-
W
E
-------
K
--------
S
-----------
E
-
V
P
A
K
-----------
H
Q
I
Q
G
M
G
S
V
E
L
T
V
R
R
--
L
D
K
M
A
S
T
L
T
E
I
F
G
Y
T
E
V
S
R
N
---------
D
---------
Q
---------
E
---------------
A
I
F
Q
-
S
-
I
K
--
G
E
A
F
G
E
I
V
V
K
Y
L
D
------
G
P
---
T
------
E
---
K
P
G
R
G
S
I
H
H
L
A
I
R
V
K
N
D
A
E
L
A
Y
W
E
E
Q
V
K
--
Q
R
G
F
H
S
S
-
G
-
I
-
I
D
--
R
--
F
----------------------
Y
F
K
---
S
L
Y
F
R
E
S
-
N
G
-
I
L
F
E
I
A
T
D
G
P
G
F
T
V
-
D
G
D
-----
V
E
H
L
G
E
K
L
D
L
P
P
F
L
E
D
Q
R
A
E
I
E
A
N
L
A
P
I
E
-----
45
Fugue
61.99
34%
-75
- C2 -
1ZSW
2
?
A:
[11-338]
VDLGTENLYFQSN
A
M
Y
E
I
K
G
H
H
H
I
S
M
V
--
T
K
N
A
N
E
N
N
H
F
Y
K
N
V
L
G
L
R
R
V
K
M
T
V
N
Q
D
D
-
P
-
S
M
-
Y
H
L
F
Y
G
D
K
T
G
S
P
G
-
T
E
L
S
F
F
E
I
-
P
L
-
V
G
R
------
T
--
Y
R
G
T
N
A
I
T
R
I
G
L
L
V
P
S
E
D
S
L
H
Y
W
K
E
R
F
E
K
F
D
V
K
H
S
E
M
T
-----
T
-----
Y
---
A
N
R
P
-
A
L
Q
F
E
D
A
E
-
G
L
R
L
V
L
L
V
SN
G
E
K
V
E
H
-
W
--------
E
T
-
W
E
-------
K
--------
S
-----------
E
-
V
P
A
K
-----------
H
Q
I
Q
G
M
G
S
V
E
L
T
V
R
R
--
L
D
K
M
A
S
T
L
T
E
I
F
G
Y
T
E
V
S
R
N
---------
D
---------
Q
---------
E
---------------
A
I
F
Q
S
I
-
K
G
--
E
A
-
F
G
E
I
V
V
K
Y
L
D
------
G
P
---
T
------
E
---
K
P
G
R
G
S
I
H
H
L
A
I
R
V
K
N
D
A
E
L
A
Y
W
E
E
Q
V
K
--
Q
R
G
F
H
S
S
-
G
-
I
-
I
D
--
R
--
F
----------------------
Y
F
K
---
S
L
Y
F
R
E
S
-
N
G
-
I
L
F
E
I
A
T
D
G
P
G
F
T
V
-
D
G
D
-----
V
E
H
L
G
E
K
L
D
L
P
P
F
L
E
D
Q
R
A
E
I
E
A
N
L
A
P
I
E
E
K
---
3
PsiBlast_PDB
61.63
33%
-81
- C2 -
4HUZ
2
?
A:
[8-313]
-------------------
S
L
H
H
I
T
I
C
--
T
G
T
A
Q
G
D
I
D
F
F
V
K
V
M
G
Q
R
F
V
K
R
T
L
F
Y
D
G
-
S
I
P
I
-
Y
H
L
Y
F
A
D
E
L
G
T
P
G
-
T
V
M
T
T
F
P
T
R
R
T
-
G
Q
K
------
G
--
R
K
G
S
N
Q
F
T
V
C
T
Y
A
I
P
-
K
G
S
L
E
W
W
I
G
H
L
N
A
H
G
I
A
T
G
E
-
P
G
----
T
-----
R
---
F
G
Q
R
-
Y
V
G
F
Q
H
P
D
C
G
I
D
F
E
V
L
---
E
D
E
N
D
T
-
R
--------
Q
P
-
Y
D
-------
S
--------
P
-----------
Y
-
V
P
I
E
-----------
H
A
Q
R
G
F
H
S
W
T
A
S
V
R
E
--
L
E
D
M
D
F
F
M
E
N
C
W
N
F
E
K
I
G
E
E
---------
G
---------
N
---------
R
---------------
H
R
Y
R
-
V
-
K
G
TT
E
S
-
G
T
I
I
D
L
L
H
E
P
DRR---
Q
G
---
S
------
W
---
T
I
A
E
G
I
I
H
H
G
A
F
A
V
P
D
----
M
D
I
Q
A
R
I
K
F
E
T
E
G
V
G
F
T
-
D
-
F
-
S
D
--
R
--
K
NRG-------------------
Y
F
E
---
S
T
Y
V
R
T
P
-
G
G
-
V
M
F
E
-
A
T
H
S
L
G
F
T
H
-
D
E
D
-----
E
R
S
L
G
M
D
L
K
V
S
P
Q
F
D
D
K
K
H
L
I
E
Q
A
M
---------
32
HHSearch
52.12
14%
-106
- C2 -
3VB0
3
?
A:
[2-273]
----------------
S
V
K
Q
L
G
Y
L
I
F
E
C
R
A
D
V
L
E
Q
M
V
V
V
Y
Q
D
I
I
G
A
V
V
E
R
D
E
G
G
----------
R
A
L
V
R
L
D
-
G
-
R
P
-
F
R
I
R
L
D
P
------------------
G
P
A
N
R
L
A
A
I
G
W
N
V
D
-
P
S
D
L
A
A
I
A
E
Q
V
E
K
A
C
Y
S
V
V
T
A
D
A
E
L
A
-
A
D
----
R
---
A
A
A
Q
-
V
R
Q
F
A
D
N
D
-
G
F
T
H
E
L
Y
---
V
E
S
S
F
P
-
T
--------
D
P
-
V
L
-------
E
--------
S
L
FV--------
C
-
G
E
E
A
-----------
N
G
I
F
G
L
G
H
L
V
V
I
V
A
D
--
R
A
K
T
Q
S
F
F
T
D
V
L
G
F
G
L
S
D
R
V
---------
T
W
PE
A
-----
D
---------
I
---------------
F
F
L
H
-
C
-
N
Q
---
R
-
H
H
T
V
A
L
S
A
P
A
------
L
---------------
G
L
K
P
G
M
V
H
H
L
M
L
E
A
K
S
K
E
Q
V
D
R
A
F
A
A
V
K
--
R
L
G
Y
D
V
L
-
M
T
I
-
G
Q
H
S
N
--
D
----------------------
K
V
Y
---
S
F
Y
M
M
A
P
-
A
G
-
F
A
V
E
L
G
F
G
G
Q
V
I
G
D
-
L
E
S
---------------------------------------
46
Fugue
49.35
18%
-71
- C2 -
1MPY
2
XYLE1_PSEPU
A:
[1-307]
-------------
M
N
K
G
V
M
R
P
G
H
V
Q
L
R
--
V
L
D
M
S
K
A
L
E
H
Y
V
E
L
L
G
L
I
E
M
D
R
D
----
D
-
Q
-
G
R
-
V
Y
L
K
A
W
T
E
V
D
K
F
S
-
L
V
L
R
E
A
D
-------------------
E
P
G
M
D
F
M
G
F
K
V
V
D
-
E
D
A
L
R
Q
L
E
R
D
L
M
A
Y
G
C
A
V
E
Q
-
L
P
AGEL------
N
---
S
C
G
R
-
R
V
R
F
Q
A
P
S
-
G
H
H
F
E
L
Y
---
A
D
K
E
Y
T
-
G
--------
K
W
-
G
L
-------
N
--------
D
-----------
V
-
N
P
E
A
WPRDLKGMAAV----
R
F
D
H
A
L
M
Y
G
D
E
--
L
P
A
T
Y
D
L
F
T
K
V
L
G
F
----
Y
L
---------
A
---------
E
---------
Q
---------------
V
L
D
E
-------
N
G
-
T
R
V
A
Q
F
L
S
L
S
TKAHD
V
A
F
---
I
------
H
---
H
P
E
K
G
R
L
H
H
V
S
F
H
L
E
T
W
E
D
L
L
R
A
A
D
L
I
S
--
M
T
D
T
S
I
D
-
I
-
G
-
P
T
--
R
--
H
----------------------
G
L
T
H
G
K
T
I
Y
F
F
D
P
S-
G
-
N
R
N
E
V
F
C
G
G
D
Y
N
Y
P
-
D
H
K
-----
P
V
T
W
T
T
D
Q
L
G
K
A
I
F
Y
H
D
R
I
L
N
E
R
F
M
T
V
L
T
-----
25
HHSearch
48.78
15%
-90
- C2 -
3B59
1
?
A:
[3-259]
--------------
L
S
R
V
T
E
I
R
Y
V
G
Y
G
--
V
K
D
F
D
A
E
K
A
F
Y
A
D
V
W
G
L
E
P
V
G
E
D
A
N
----------
N
A
W
F
K
A
Q
-
G
--
A
-
D
E
H
H
V
V
Q
L
-
R
R
--------------
A
D
E
N
R
I
D
V
I
A
L
A
A
D
S
R
S
D
V
D
A
L
R
A
S
V
E
A
A
G
C
K
V
A
S
E
P
-----
A
VLAT-
P
---
G
G
G
Y
-
G
F
R
F
F
S
P
D
-
G
L
L
F
E
V
S
---
S
D
V
A
K
G
-
A
--------
K
R
-------------------
D
-----------
L
-
A
R
W
E
-----------
G
V
P
V
K
I
S
H
I
V
L
H
S
P
N
--
H
Q
D
M
V
K
F
F
T
D
V
L
G
F
K
V
S
D
W
L
---------
G
---------
D
F--------
M
---------------
C
F
L
R
-
C
-
N
S
---
A
-
H
H
R
I
A
I
L
P
--------------------------
G
P
P
C
L
N
H
V
A
Y
D
M
L
S
V
D
D
M
M
R
G
A
H
R
L
K
--
V
K
G
I
D
I
G
W
G
-
P
-
G
R
--
H
--
T
AG--------------------
N
N
T
---
F
S
Y
F
V
T
P
-
G
G
-
F
V
T
E
Y
T
S
E
L
E
E
V
D
F
-------------------------------------------
29
HHSearch
48.00
16%
-80
* C2 *
1MPY
2
XYLE1_PSEPU
A:
[1-293]
-------------
M
N
K
G
V
M
R
P
G
H
V
Q
L
R
--
V
L
D
M
S
K
A
L
E
H
Y
V
E
L
L
G
L
I
E
M
D
R
D
D
Q
---------
G
R
V
Y
L
K
A
W
T
E
V
D
K
-
F
S
L
V
L
R
E
------------------
A
D
E
P
G
M
D
F
M
G
F
K
V
V
D
E
D
A
L
R
Q
L
E
R
D
L
M
A
Y
G
C
A
V
E
Q
L
P
-----
A
GEL--
N
---
S
C
G
R
-
R
V
R
F
Q
A
P
S
-
G
H
H
F
E
L
Y
---
A
D
K
E
Y
T
-
G
---------
K
-
W
G
-------
L
NDVNPEAW
P
-----------
R
-
D
L
K
G
-----------
M
A
A
V
R
F
D
H
A
L
M
Y
G
D
E
--
L
P
A
T
Y
D
L
F
T
K
V
L
G
F
Y
L
A
E
Q
V
---------
L
D
ENGTR---
V
---------
A
---------------
Q
F
L
S
-
L
-
S
T
---
K
-
A
H
D
V
A
F
I
H
------------------------
H
P
E
K
G
R
L
H
H
V
S
F
H
L
E
T
W
E
D
L
L
R
A
A
D
L
I
S
--
M
T
D
T
S
I
D
I
G
-
P
-
T
R
--
H
GL
T
----------------------
H
G
K
---
T
I
Y
F
F
D
P
-
S
G
-
N
R
N
E
V
F
C
G
G
D
Y
N
Y
P
-
D
H
K
P
V
T
W
T
T
D
Q
L
G
K
A
I
F
Y
------------------------
30
HHSearch
47.85
13%
-94
- C2 -
1LGT
4
BPHC_BURXL
A:
[1-273]
----------------
S
I
R
S
L
G
Y
M
G
F
A
--
V
S
D
V
A
A
W
R
S
F
L
T
Q
K
L
G
L
M
E
A
G
T
T
D
N
----------
G
D
L
F
R
I
D
-
S
--
R
-
A
W
R
I
A
V
Q
Q
-----------------
G
E
V
D
D
L
A
F
A
G
Y
E
V
A
D
A
A
G
L
A
Q
M
A
D
K
L
K
Q
A
G
I
A
V
T
T
G
D
A
S
L
--
A
R
R
---
R
---
G
V
T
G
-
L
I
T
F
A
D
P
F
-
G
L
P
L
E
I
Y
---
Y
G
A
S
E
V
F
E
--------
K
P
-
F
L
-------
P
--------
G
AA---------
V
-
S
G
F
L
-----------
T
G
E
Q
G
L
G
H
F
V
R
C
V
P
D
--
S
D
K
A
L
A
F
Y
T
D
V
L
G
F
Q
L
S
D
V
I
---------
D
---------
M
KMGPD
V
T
V
P
A
---------------
Y
F
L
H
-
C
-
N
E
---
R
-
H
H
T
L
A
I
A
A
------------------------
F
P
L
P
K
R
I
H
H
F
M
L
E
V
A
S
L
D
D
V
G
F
A
F
D
R
V
D
--
A
D
G
L
I
T
S
-
T
-
L
-
G
R
--
H
TN
D
----------------------
H
M
V
---
S
F
Y
A
S
T
P
-
S
G
-
V
E
V
E
Y
G
W
S
A
R
T
V
D
R
-
S
W
V
-----
V
---------------------------------
28
HHSearch
46.39
14%
-101
- C2 -
1KW3
3
BPHC_PSES1
B:
[1-276]
----------------
S
I
E
R
L
G
Y
L
G
F
A
--
V
K
D
V
P
A
W
D
H
F
L
T
K
S
V
G
L
M
A
A
G
S
A
G
D
----------
A
A
L
Y
R
A
D
----
Q
-
R
A
W
R
I
A
V
Q
-
P
---------------
G
E
L
D
D
L
A
Y
A
G
L
E
V
D
D
A
A
A
L
E
R
M
A
D
K
L
R
Q
A
G
V
A
F
T
R
G
D
-----
E
ALMQQ
R
---
K
V
M
G
-
L
L
C
L
Q
D
P
F
-
G
L
P
L
E
I
Y
---
Y
G
P
A
E
I
F
H
--------
E
P
-
F
L
-------
P
S-------
A
-----------
P
V
S
G
F
V
-----------
T
G
D
Q
G
I
G
H
F
V
R
C
V
P
D
--
T
A
K
A
M
A
F
Y
T
E
V
L
G
F
V
L
S
D
I
I
---------
D
IQMGPETSV
P
---------
A
---------------
H
F
L
H
-
C
-
N
G
---
R
-
H
H
T
I
A
L
A
A
F
------------------------
P
I
P
K
R
I
H
H
F
M
L
Q
A
N
T
I
D
D
V
G
Y
A
F
D
R
L
D
--
A
A
G
R
I
T
S
-
L
-
L
-
G
R
--
H
TN
D
----------------------
Q
T
L
---
S
F
Y
A
D
T
P
-
S
P
M
I
E
V
E
F
G
W
G
P
R
T
V
D
S
-
S
W
T
-----
V
A
R
-------------------------------
37
HHSearch
45.99
11%
-95
- C2 -
2ZYQ
1
HSAC_MYCTU
A:
[2-275]
----------------
S
I
R
S
L
G
Y
L
R
I
E
--
A
T
D
M
A
A
W
R
E
Y
G
L
K
V
L
G
M
V
E
G
K
G
A
P
E
---------
G
A
L
Y
L
R
M
D
D
F
--
P
-
A
R
L
V
V
V
P
G
------------------
E
H
D
R
L
L
E
A
G
W
E
C
A
N
A
E
G
L
Q
E
I
R
N
R
L
D
L
E
G
T
P
Y
K
E
A
T
-----
A
A
E
L
A
D
R
---
R
V
D
E
-
M
I
R
F
A
D
P
S
-
G
N
C
L
E
V
F
---
H
G
T
A
L
E
-
H
--------
R
R
-
V
V
-------
S
--------
P
-----------
Y
G
H
R
F
V
-----------
T
G
E
Q
G
M
G
H
V
V
L
S
T
R
D
--
D
A
E
A
L
H
F
Y
R
D
V
L
G
F
R
L
R
D
S
M
---------
R
---------
L
---------
P
PQMVGRPAD
G
P
P
A
W
L
R
F
F
G
-
C
-
N
P
---
R
-
H
H
S
L
A
F
L
P
------------------------
M
P
T
S
S
G
I
V
H
L
M
V
E
V
E
Q
A
D
D
V
G
L
C
L
D
R
A
L
--
R
R
K
V
P
M
S
-
A
T
L
-
G
R
--
H
VN
D
----------------------
L
M
L
---
S
F
Y
M
K
T
P
-
G
G
-
F
D
I
E
F
G
C
E
G
R
Q
V
D
--------------------------------------------
40
HHSearch
45.43
12%
-102
- C2 -
3ISQ
7
HPPD_HUMAN
A:
[6-334]
--------------
R
G
R
F
L
H
F
H
S
V
T
F
W
--
V
G
N
A
K
Q
A
A
S
F
Y
C
S
K
M
G
F
E
P
L
A
Y
R
G
L
E
T
G
-
S
-
R
E
V
V
S
H
V
I
K
Q
--
G
--
K
-
I
V
F
V
L
S
S
A
-
L
N
-
P
W
N
K
E
M
G
D
H
L
--
V
K
H
G
D
G
V
K
D
I
A
F
E
V
E
---
D
C
D
Y
I
V
Q
K
A
R
E
R
G
A
K
I
M
R
E
P
-----
W
V
E
---
Q
D
KF
G
K
V
K
-
F
A
V
L
Q
T
Y
G
-
D
T
T
H
T
L
V
---
E
K
M
N
Y
I
-
G
---------
Q
-
F
L
-------
P
--------
G
YEAPAFMD
P
L
L
P
-
K
L
P
K
-----------
C
S
L
E
M
I
D
H
I
V
G
N
Q
P
D
QE
M
V
S
A
S
E
W
Y
L
K
N
L
Q
F
H
R
F
W
S
V
---------
D
DTQVHT---
E
Y
S
S
L
R
----
S
---------------
I
V
V
A
-
N
-
Y
E
---
E
-
S
I
K
M
P
I
N
E
P
A
------
P
G
KKK
S
Q
I
Q
E
Y
V
D
---
Y
N
G
G
A
G
V
Q
H
I
A
L
K
T
E
D
---
I
I
T
A
I
R
H
L
R
--
E
R
G
L
E
F
L
-
S
-
V
P
S
T
--
Y
--
Y
K
Q
L
R
E
K
L
K
T
AKIKVKEN
I
D
A
L
E
E
L
K
---
I
L
V
D
Y
D
E
-
K
G
-
Y
L
L
Q
I
F
T
K
P
V
Q
----------------------------------------------
26
HHSearch
43.02
14%
-91
- C2 -
2WL9
4
?
A:
[1-287]
--------------
M
A
K
V
T
E
L
G
Y
L
G
L
S
--
V
S
N
L
D
A
W
R
D
Y
A
A
G
I
M
G
M
Q
V
V
D
D
G
E
D
---------
D
R
I
Y
L
R
M
D
--
R
W
H
-
H
R
I
V
L
H
A
D
------------------
G
S
D
D
L
A
Y
I
G
W
R
V
A
G
P
V
E
L
D
E
L
A
E
Q
L
K
N
A
G
I
P
F
E
V
A
S
-----
D
A
D
A
A
E
R
---
R
V
L
G
-
L
V
K
L
H
D
P
G
-
G
N
P
T
E
I
F
---
Y
G
P
Q
V
D
-
T
S-------
S
P
-
F
H
-------
P
--------
G
RPM--------
F
-
G
K
F
V
-----------
T
E
G
Q
G
L
G
H
I
I
I
R
E
D
D
--
V
E
E
A
T
R
F
Y
R
-
L
L
G
L
E
G
A
V
E
Y
K
F
A
L
P
NG
A
V
G
---------
T
---------
P
---------------
V
F
M
H
-
C
-
N
D
---
R
-
H
H
S
L
A
F
G
V
------------------------
G
P
M
D
K
R
I
N
H
L
M
I
E
Y
T
H
L
D
D
L
G
Y
A
H
D
L
V
R
--
Q
Q
K
I
D
V
T
L
Q
-
I
-
G
K
--
H
SN
D
----------------------
E
A
L
---
T
F
Y
C
A
N
P
-
S
G
-
W
L
W
E
P
G
W
G
S
R
P
A
P
---
A
Q
-----
Q
E
H
Y
L
R
D
I
F
G
H
D
N
---------------------
5
PsiBlast_PDB
42.65
25%
-134
- C2 -
2P7K
2
FOSX_LISMO
A:
[2-119]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
L
S
H
I
T
L
I
V
K
D
--
L
N
K
T
T
A
F
L
Q
N
I
F
N
A
E
E
I
Y
S
-------------------------------------------------
L
-
S
-
K
E
--
K
F
-
F
L
I
A
G
L
W
I
C
I
------
M
E
---
G
------
D
---
S
L
Q
E
R
T
Y
N
H
I
A
F
Q
I
Q
S
E
E
V
D
-
E
Y
T
E
R
I
K
--
A
L
G
V
E
M
K
-
P
-
E
-
R
P
--
R
VQ
G
----------------------
E
G
R
---
S
I
Y
F
Y
D
F
-
D
N
-
H
L
F
E
L
----------------------------------------------------
27
HHSearch
42.47
15%
-88
- C2 -
3HPY
2
?
A:
[2-289]
-------------
A
M
T
G
V
L
R
P
G
H
A
Q
V
R
--
V
L
N
L
E
E
G
I
H
F
Y
R
N
V
L
G
L
V
E
T
G
R
D
D
Q
------
G
---
R
V
Y
F
K
C
W
-
D
E
R
D
-
H
S
C
Y
I
I
R
E
-
A
----------------
D
T
A
G
I
D
F
F
G
F
K
V
L
D
K
A
T
L
E
K
L
D
A
D
L
Q
A
Y
G
L
T
T
T
R
I
P
-----
A
GEM--
L
---
E
T
G
E
-
R
V
R
F
E
L
P
S
-
G
H
L
I
E
L
Y
---
A
E
K
T
C
V
-
G
NGISEVNP
A
P
-
W
N
-------
A
--------
Q
-------------
R
E
H
G
-----------
I
A
P
I
Q
L
D
H
C
L
L
Y
G
P
N
--
I
A
E
V
Q
K
I
F
T
E
V
L
G
F
Y
L
V
E
R
V
---------
L
S
PDGDSD--
M
---------
G
---------------
I
W
L
S
-
C
-
S
H
---
K
-
V
H
D
I
A
F
V
E
------------------------
Y
P
E
K
G
K
L
H
H
C
S
F
L
L
E
S
W
E
Q
V
L
R
A
G
D
I
M
S
--
M
N
E
V
N
V
D
I
G
-
P
-
T
R
--
H
--
G
VT--------------------
R
G
C
---
T
I
Y
A
W
D
P
-
S
G
-
N
R
F
E
T
F
M
G
G
Y
H
P
Y
P
D
Y
E
P
-----
L
S
W
T
Y
D
N
F
--------------------------
31
HHSearch
42.13
16%
-66
- C2 -
3LM4
3
?
A:
[5-278]
-------------
A
R
F
D
I
A
H
L
A
R
A
E
L
F
--
S
P
K
P
Q
E
T
L
D
F
F
T
K
F
L
G
M
Y
V
T
H
R
E
G
Q
----------
S
V
Y
L
R
G
Y
-
E
D
P
Y
P
W
S
L
K
I
T
E
------------------
A
P
E
A
G
M
G
H
A
A
M
R
T
S
S
P
E
A
L
E
R
R
A
K
S
L
T
D
G
N
V
D
G
T
W
-
S
-----
E
DQ---
F
---
G
Y
G
K
-
T
F
E
Y
Q
S
P
D
-
G
H
N
L
Q
L
L
---
W
E
A
E
K
Y
-
V
--------
A
P
P
E
L
RSKILTR
P
S-------
K
-----------
K
-
P
L
Q
G
-----------
I
P
V
K
R
I
D
H
L
N
L
M
S
S
D
--
V
T
A
V
K
D
S
F
E
R
H
L
G
F
R
T
T
E
R
V
---------
V
---------
D
GNVEI----
G
---------------
A
W
M
S
-
S
-
N
L
---
L
-
G
H
E
V
A
C
M
R
D
M
----------------------
T
G
G
H
G
K
L
H
H
L
A
F
F
Y
G
T
G
Q
H
N
I
D
A
V
E
M
F
R
--
D
Y
D
I
Q
I
E
A
G
-
P
-
D
K
--
H
--
G
IT--------------------
Q
S
Q
---
F
L
Y
V
F
E
P
-
G
G
-
N
R
I
E
L
F
G
E
A
G
Y
L
H
--------------------------------------------