@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu05610: (2016-06-09 )
MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKSTLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFHQLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDRYFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMNGLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYTVRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLLNIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRHLGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLSQYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQEVLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD
Atome Classification :
(20 SA)
-----------------------------------------------------------------.........10-....-.-------...20--------......-..30-........40........50--------------.-------------------------........--60-----------------.--.----------....--------------.--.------70..--------------------.--------------------------..---.-------.------------------.80-----..-------------.--------------------.-------------.----------.-..90-.....---.----.---..100..------------------------------------------.....110.......120--.--......130...----....140.......---150.......160.......170.------......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300-.---......310.......320.......330...---------------....340.---------------------..-...------..350-------------..---------------------...-------------------------------...-------------------------------------------------------------------------360.-.-------------------------------..--...370..------------------------------------------------------------------.--------..--...------------380----------------------------.----.--.......390---......----------..-400.......410.......420....---...430.......440.......450----..---.----....460...-....470.-...------.------.--.480......-.-490-.......500.......510.......520.......530.......540.....-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------MK
E
I
V
T
LTN
V
S
-
Y
EVK-
D
-------
Q
T
V
F
K
--------
H
VNASV-QQG
D
-
I
I
G
I
IGKNGA
G
K
S
T
L
L
H
L
I
---------------
H
-------------------------NDLAPA
Q
G
--
Q
I
-----------------
L
--
R
----------
K
D
I
K
--------------
L
--
A
------
L
V
EQ--------------------E--------------------------TA---A-------Y------------------SFA-----DQ-------------T--------------------
P
-------------
A
----------
E
-
K
K
L
--
L
E
K
WH---V----
P
---
L
R
D
F
H
Q
L------------------------------------------SG
G
E
K
L
K
A
R
L
A
KGLSEDA--
D
--
L
L
L
LDEPTNHL
D
----
E
K
S
L
Q
F
L
I
Q
Q
L
K
HY---N
G
T
V
I
L
V
SHD
R
Y
F
L
D
E
A
A
T
K
IWSL------ED
Q
T
L
I
E
F
KGNY
S
G
Y
M
K
F
R
E
K
K
R
L
T
Q
Q
R
E
Y
E
K
Q
Q
K
M
V
E
R
I
E
A
Q
M
N
G
L
A
S
W
S
E
K
AHA
Q
S
T
K
K
E
G
F
K
E
Y
H
R
V
KAKRT
D
A
Q
I
K
S
K
Q
K
R
L
E
K
E
L
E
K
AKAEPVTP
E
Y
T
V
R
F
S
I
DTTHK
T
G
K
R
F
L
E
V
Q
N
V
T
K
A
FG-E---RTLFKNA
N
F
T
I
QHG
E
K
V
A
I
I
GPNGSG
K
T
T
L
L
N
---------------
I
I
LGQE-T---------------------AE-G
S
V
------
W
VSP--------------SA---------------------N
I
G
-------------------------------
Y
L
T
-------------------------------------------------------------------------
Q
E
V
F-D-------------------------------LP--LEQ
T
P
-
E
E
------------------------------------------------------------------
L
--------FE--NET------------F------------------------------K----A--R
G
H
V
Q
N
L
M
R
----
H
LGF
T
A
----------
A
Q
-
W
T
E
P
I
K
HMSMG
E
R
V
K
I
K
L
M
A
Y
I
LEEK
D
---
V
L
I
LDEPTNHLDLP
S
R
E
Q
L
E
E
T
L
S
QY----S
G
---
T
----
L
L
A
V
SHD
R
Y
F
-
L
EKTTN
S
K
-
L
V
I
------S------N--N
G
I
E
K
Q
L
N
DV-P-SER-N
E
R
E
E
L
R
L
KL
E
T
E
R
Q
E
V
L
G
K
LSFMTPND
K
G
Y
K
E
L
D
Q
A
F
N
E
L
T
K
R
I
K
E
LDHQDKKD-------
29
HHSearch
85.79
27%
-96
- C3 -
2IW3
7
EF3A_YEAST
A:
[440-979]
-------------------------------------------------------------------------
E
F
S
-
L
A
Y
G
-
A
-------
K
I
L
L
N
--------
K
T
Q
L
R
L
-
K
R
A
R
-
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
---------------
A
-------------------------
N
G
Q
V
--
D
G
--
F
P
-----------------
T
--
Q
----------
E
E
C
R
--------------
T
--
V
------
Y
V
E
H
--------------------
D
--------------------------
I
D
---
G
THSDT--
S
------------------
V
L
D
-----
F
V
-------------
F
E
S
GVGT--------------
K
-------------
E
----------
A
I
K
D
K
--
L
I
E
F
G
---
F
T
D
E
M
I
---
A
M
P
I
S
A
L
------------------------------------------
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
--
I
L
L
L
D
E
P
T
N
H
L
D
----
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
---
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
------------
K
A
Y
E
E
L
S
N
T
------
D
---------
L
-------------------
E
--------
F
-
K
----
F
P
E
-
P
-----
G
Y
L
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
-
G
TS-
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
---------------
V
L
T
G
E
L
L
P
---------------------
T
S
-
G
E
V
------
Y
T
H
E
--------------
N
C
---------------------
R
I
A
-------------------------------
Y
I
K
-------------------------------------------------------------------------
Q
H
A
F
A
H
-------------------------------
I
E
SH
L
D
K
T
P
-
S
E
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
--------
I
G
--
M
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQFRP
L
----
T
--
R
K
E
I
E
E
H
C
S
----
M
L
G
L
D
P
----------
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
---
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
---
G
----
V
I
I
I
T
H
S
A
E
F
-
T
K
N
L
T
E
E
V
-
W
A
V
------
K
------
D
--
G
R
M
T
P
S
-------------------------------------------------------------------------
28
HHSearch
80.32
28%
-72
- C3 -
4FIN
13
ETTA_ECOLI
A:
[3-535]
------------------------------------------------------------------
Q
F
V
Y
T
M
H
R
V
G
-
K
V
V
P
P
K
-------
R
H
I
L
K
--------
N
I
S
L
S
F
-
F
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
---------------
A
-------------------------
G
I
D
K
D
I
E
G
--
E
A
R
----------------
P
--
Q
----------
P
D
I
K
--------------
I
--
G
------
Y
L
P
Q
--------------------
E
--------------------------
P
Q
---
L
NPEH---
T
------------------
V
R
E
-----
S
I
-------------
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
DPDAD
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
IQL
N
V
Q
L
E
R
A
--
A
D
A
L
R
---
L
PD--
W
---
D
A
K
I
A
N
L
------------------------------------------
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
--
M
L
L
L
D
E
P
T
N
H
L
D
----
A
E
S
V
A
W
L
E
R
F
L
H
D
F
---
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
-------
E
L
E
W
V
R
Q
G
-----
T
-------
K
---------
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
---
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
-
D
---
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
---------------
M
I
S
G
Q
E
Q
P
---------------------
D
S
-
G
T
I
------
T
L
G
E
--------------
T
V
---------------------
K
L
A
-------------------------------
S
V
D
-------------------------------------------------------------------------
Q
F
R
D
-
S
-------------------------------
M
D
--
N
S
K
T
V
-
W
E
------------------------------------------------------------------
E
--------
V
S
--
G
G
L
------------
D
IMKIG-------------------------
N
----
T
--
E
M
P
S
R
A
Y
V
G
----
R
F
N
F
K
G
----------
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
---
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
I
-
L
D
Y
------
Q
------
D
E-
G
K
V
E
F
F
E
G
N
F
-
T
-
E
Y
E
-
E
Y
K
K
----------------------------------------------------------
2
PsiBlast_PDB
78.76
28%
-68
- C3 -
4FIN
12
ETTA_ECOLI
A:
[21-518]
--------------------------------------------------------------------------------------------
I
L
K
--------
N
I
S
L
S
F
-
F
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
---------------
A
-------------------------
G
I
D
K
D
I
E
G
--
E
A
-----------------
R
P
-
Q
----------
P
D
I
K
--------------
I
--
G
------
Y
L
P
Q
E
P
Q
L
NPEHT
V
R
---------
E
--------------------------
S
I
---
E
-------
E
------------------
A
V
S
-----
E
V
-------------
V
--------------------
N
-------------
A
----------
L
-
K
R
L
--
D
E
V
Y
A
---
L
YAD-
P
---
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
IQL
N
V
Q
L
E
R
A
A
D
A
L
RLPDWDAKIANL------
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
--
M
L
L
L
D
E
P
T
N
H
L
D
----
A
E
S
V
A
W
L
E
R
F
L
H
D
F
---
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
-
Q
K
D
Q
R
L
A
Q
E
---------------------
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
--
L
E
W
V
R
Q
G
T
K
----
K
G
K
A
R
L
A
R
F
E
---
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
-
D
---
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
---------------
M
I
S
G
Q
E
-
Q
---------------------
P
D
S
G
T
I
------
T
L
G
E
--------------
T
V
---------------------
K
L
A
-------------------------------
S
V
D
-------------------------------------------------------------------------
Q
F
R
D
-
S
-------------------------------
M
D
--
N
S
K
T
V
W
E
E
------------------------------------------------------------------
V
--------
S
G
--
G
L
D
------------
I
------------------------------
M
----
K
--
I
G
N
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
----------
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
---
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
I
-
L
D
Y
------
Q
------
D
--
E
G
-----------------------------------------------------------------------------
1
PsiBlast_PDB
77.90
28%
-54
- C3 -
3J5S
-
ETTA_ECOLI
D:
[21-518]
--------------------------------------------------------------------------------------------
I
L
K
--------
N
I
S
L
S
F
-
F
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
---------------
A
-------------------------
G
I
D
K
D
I
E
G
--
E
A
-----------------
R
P-
Q
----------
P
D
I
K
--------------
I
--
G
------
Y
L
P
Q
EPQLNPEHTVR---------
E
--------------------------
S
I
---
E
-------
E
------------------
A
V
S
-----
E
V
-------------
V
--------------------
N
-------------
A
----------
L
-
K
R
L
--
D
E
V
Y
A
---
L
YAD-
P
---
D
A
D
F
D
K
L
AAEQGRLEEIIQAHDGHNLNVQLERAADALRLPDWDAKIANL
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
--
M
L
L
L
D
E
P
T
N
H
L
D
----
A
E
S
V
A
W
L
E
R
F
L
H
D
F
---
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
-
Q
K
D
Q
R
L
A
Q
E
---------------------
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
--
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
L
A
R
F
E
---
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
-
D
---
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
---------------
M
I
S
G
Q
E
-
Q
---------------------
P
D
S
G
T
I
------
T
L
G
E
--------------
T
V
---------------------
K
L
A
-------------------------------
S
V
D
-------------------------------------------------------------------------
Q
F
R
D
-
S
-------------------------------
M
D
--
N
S
K
T
V
W
E
E
------------------------------------------------------------------
V
SGGLDIMK
I
G
--
N
T
E
------------
M
------------------------------
P
----
S
--
R
A
Y
V
G
--------
R
F
N
F
K
G
----------
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
---
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
I
-
L
D
Y
------
Q
------
D
--
E
G
-----------------------------------------------------------------------------
33
HHSearch
69.97
23%
-87
- C3 -
3OZX
5
?
A:
[4-463]
-------------------------------------------------------------------------
E
V
I
-
H
R
Y
K
V
N
-------
G
F
K
L
F
--------
G
L
P
T
-
P
-
K
N
N
T
-
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
---------------
A
-------------------------
G
E
I
I
P
N
F
G
--
D
P
N----------------
S
--
K
VG
K
D
E
V
L
K
R
F
R
G
K
E
--------------
I
--
Y
------
N
Y
F
K
--------------------
E
--------------------------
L
Y
S
NE
L
-------
K
I
V
H
KIQY
V
E
Y
A
S
KFLKGT
V
N
E
-----
I
L
-------------
T
K
I
DE----------------
R
-------------
G
----------
K
K
D
E
V
--
K
E
L
L
N
MTN
L
----
W
---
N
K
D
A
N
I
L
------------------------------------------
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
--
D
--
V
Y
I
F
D
Q
P
S
S
Y
L
D
----
V
R
E
R
M
N
M
A
K
A
I
R
E
L
L
K-
N
K
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
------
Y
-
G
E
S
S
V
Y
-
G
R
V
S
K
S
Y
A
A
R
V
G
---------------
I
---
N
N
F
L
K
G
Y
L
P
A
E
------
N
M
K
-------------
I
R
P
D
E
I
K
---
F
M
L
K
---------------------------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
G
-
D
----
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
---------------
I
L
V
G
E
I
T
A
---------------------
D
E
-
G
S
V
------
T
P
E
---------------
K
Q
---------------------
I
L
S
-------------------------------
Y
K
P
-------------------------------------------------------------------------
Q
R
I
F
---------------------------------
P
N
--
Y
D
G
T
V
-
Q
Q
------------------------------------------------------------------
Y
--------
L
E
--
N
A
S
------------
K
DALS--------------------------
T
----
S
--
S
W
F
F
E
E
V
T
K
----
R
L
N
L
H
-----------
R
L
-
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
D
---
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
K
A
---
V
----
T
F
I
I
D
H
D
L
S
I
-
H
D
Y
I
A
D
R
I
-
I
V
F
------
K
------
G
--
E
P
-----------------------------------------------------------------------------
31
HHSearch
69.65
23%
-84
- C3 -
3BK7
4
?
A:
[83-547]
--------------------------------------------------------------------
A
I
S
I
V
N
L
P
-
E
Q
L
D
-
E
D
CVHRYG
V
N
A
F
V
--------
L
Y
R
L
P
I
V
K
D
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
---------------
A
-------------------------
G
Q
L
I
P
N
L
C
--
E
D
N----------------
D
S
W
D
N
V
I
R
A
F
----
R
G
N
E
L
Q
N
Y
F
E
R
L
K
N
GE
I
R
P
--
V
------
V
K
P
Q
--------------------
Y
--------------------------
V
D
---
L
L
P
K
A
V
KG
K
------------------
V
R
E
-----
L
L
-------------
K
K
V
------------------
D
EV-----------
G
----------
K
F
E
E
V
--
V
K
E
L
E
---
L
ENV-
L
---
D
R
E
L
H
Q
L
------------------------------------------
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
--
F
Y
F
F
D
E
P
S
S
Y
L
D
----
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
------
Y
G
E
P
G
-
V
Y
-
G
I
F
S
K
P
K
G
T
R
------------------
N
G
I
N
E
F
L
Q
G
Y
L
K
D
--------
E
N
-
V
R
F
----------
R
--
P
Y
E
---
I
R
F
T
K
-------
L
S
-----------
E
R
V
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
G
-
S
----
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
---------------
M
L
A
G
V
E
E
P
---------------------
T
E
-
G
K
V
------
E
W
D
----------------
L
---------------------
T
V
A
-------------------------------
Y
K
P
-------------------------------------------------------------------------
Q
Y
I
K
---------------------------------
A
E
--
Y
E
G
T
V
-
Y
E
------------------------------------------------------------------
L
--------
L
S
--
K
I
D
------------
S
S
K
L
---------------------------
N
----
S
--
N
F
Y
K
T
E
L
L
K
----
P
L
G
I
I
-----------
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
---
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
I
V
F
------
E
------
G
---------------------------------------------------------------------------------
34
HHSearch
67.99
22%
-82
- C3 -
1YQT
4
?
A:
[25-480]
------------------------------------------------------------------------
E
D
C
V
-
H
R
Y
G
V
N
-------
A
F
V
L
Y
--------
R
L
P
-
V
V
-
K
E
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
---------------
A
-------------------------
G
Q
L
I
P
N
L
C
GD
N
D
S----------------
W
--
D
G
V
I
R
A
F
----
R
G
N
E
L
Q
N
Y
F
E
K
L
K
N
GE--
I
R
P
V
------
V
K
P
Q
--------------------
Y
--------------------------
V
D
---
L
IPKA---
V
KGK---------------
V
I
E
-----
L
L
K
K
A
----------
D
E-------------------
T
-------------
G
----------
K
L
E
E
V
--
V
K
A
L
E
---
L
ENV-
L
---
E
R
E
I
Q
H
L
------------------------------------------
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
--
F
Y
F
F
D
E
P
S
S
Y
L
D
----
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
G
-
V
Y
-
G
I
F
S
Q
P
K
G
T
R
---------------
N
---
G
I
N
E
F
L
R
G
Y
L
K
D
--------
E
N
V
-
R
F
R
---------
P
---
Y
E
---
I
K
F
T
K
-------
T
G
E
------
R
V
-----
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
-
S
----
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
---------------
M
L
A
G
V
E
E
P
---------------------
T
E
-
G
K
I
------
E
W
D
----------------
L
---------------------
T
V
A
-------------------------------
Y
K
P
-------------------------------------------------------------------------
Q
Y
I
K
---------------------------------
A
D
--
Y
E
G
T
V
-
Y
E
------------------------------------------------------------------
L
--------
L
S
--
K
I
D
------------
A
S
K
L
---------------------------
N
----
S
--
N
F
Y
K
T
E
L
L
K
----
P
L
G
I
I
-----------
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
---
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
M
V
F
------
E
------
G
--
E
P
G
----------------------------------------------------------------------------
45
HHSearch
63.12
26%
-115
- C3 -
1Z47
1
?
A:
[11-228]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
---
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
---------------
L
I
A
G
L
E
R
P
---------------------
T
K
-
G
D
V
------
W
I
G
G
KRVTDLPPQ-----
K
R
---------------------
N
V
G
-------------------------------
L
V
F
-------------------------------------------------------------------------
Q
N
Y
A
---------------------------------
L
F
--
Q
H
M
T
V
-
Y
D
------------------------------------------------------------------
N
--------
V
S
--
F
G
L
------------
R
E
K
RVP
K
D
-----------------------
E
----
M
--
D
A
R
V
R
E
L
L
R
----
F
M
R
L
E
-----------
S
Y
-
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
---
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
---
T
----
S
V
F
V
T
H
D
Q
E
E
-
A
L
E
V
A
D
R
V
-
L
V
L
------
H
------
E
--
G
N
V
E
Q
F
G
------------------------------------------------------------------------
32
HHSearch
62.98
20%
-70
- C3 -
3J16
2
RLI1_YEAST
B:
[82-555]
-------------------------------------------------------------------------
H
V
T
-
H
R
Y
S
-
A
N------
S
F
K
L
H
--------
R
L
P
-
T
P
-
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
---------------
A
-------------------------
G
K
Q
K
P
N
L
G
--
R
F
D----------------
D
--
P
P---------
E
W
Q
E
I
-------------
I
--
K
------
Y
F
R
G
--------------------
S
EL
Q
N
Y
F
T
K
M
L
E
DD
I
K
A
I
I
KPQYVDN
I
P
R
---
A
I
KGPVQ-
K
------------------
V
G
E
-----
L
L
-------------
K
L
R
MEKS--------------
P
-------------
E
----------
D
V
K
R
Y
--
I
K
I
L
Q
---
L
ENV-
L
---
K
R
D
I
E
K
L
------------------------------------------
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
--
V
Y
M
F
D
E
P
S
S
Y
L
D
----
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
S
-
V
Y
-
G
V
V
T
L
P
A
S
V
R
-----
E
----------
G
---
I
N
I
F
L
D
G
H
I
P
A
---------
E
-----------------
N
L
R
F
R
T
E
A
L
Q
-
F
-
R
-
I
A
-
D
A
T
-------
E
--
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
-----
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
---------------
L
L
A
G
A
L
K
P
---------------------
D
E
-
G
Q
D
------
I
P
----------------
K
L
---------------------
N
V
S
-------------------------------
M
K
P
-------------------------------------------------------------------------
Q
K
I
A
-
P
-------------------------------
K
---
F
P
G
T
V
-
R
Q
------------------------------------------------------------------
L
--------
F
F
--
K
K
I
RGQ---------
F
------------------------------
L
----
N
--
P
Q
F
Q
T
D
V
V
K
----
P
L
R
I
D
-----------
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
---
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
---
T
----
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
V
F
------
E
------
G
I
P
S
K
N
A
H
A
R
A
P
E
---------------------------------------------------------------------
53
Fugue
62.62
18%
-55
- C3 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
C
P
F
D
A
I
Q
I
I
N
L
P
-
T
N
L
E
-
A
-------
H
V
T
H
R
YSAN
S
F
K
L
H
R
L
P
T
P
-
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
---------------
A
GKQKPNLGRFDDPPE
W
Q
E
I
I
K
Y
F
RG
S
E
L
Q
N
Y
F
T
--
K
M
-----------------
L
--
E
----------
D
D
I
K
--------------
A
--
I
------
I
K
P
Q
YVDN
I
P
R
A
I
KGPVQK
V
G
E
L
L
K
--------------------------
L
R
---
M
-------
E
------------------
K
S
P
-----
E
D
-------------
V
--------------------
K
-------------
R
----------
Y
-
I
K
I
--
L
Q
L
E
N
---
V
----
L
---
K
R
D
I
E
K
L
------------------------------------------
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
--
V
Y
M
F
D
E
P
S
S
Y
L
D
----
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
--------------------------------------
S
V
Y
G
V
V
T
------
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
-
S
L
K
K
T
Q
G
D
F
V
L
N
V
E
E
G
E
-------------------
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
---------------
L
L
A
G
A
L
-
K
---------------------
P
D
-
E
G
Q
-------
D
I
P
--------------
K
L
---------------------
N
V
S
-------------------------------
M
K
P
-------------------------------------------------------------------------
Q
K
I
A
-
P
-------------------------------
K
F
--
P
G
T
V
R
-
Q
L
------------------------------------------------------------------
F
--------
F
K
K
I
R
G
Q
------------
F
------------------------------
L
----
N
--
P
Q
F
Q
T
D
V
V
K
----
P
L
R
I
D
D
----------
I
I
--
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
---
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
----
I
L
---
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
V
F
------
E
------
G
--
I
P
S
K
N
A
H
A
R
A
-
P
-
E
S
L
-
L
T
G
C
N
R
F
L
K
N
L
--------
N
V
T
F
R
R
D
P
N
S
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
NTGI---
39
HHSearch
62.26
24%
-67
- C3 -
2R6F
3
?
A:
[498-940]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
S
R
S
A
G
T
L
------------------------------------------
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
TG
V
--
L
Y
V
L
D
E
P
S
I
G
L
H
----
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
A
-
A
D
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
A
-
G
T
P
E
E
V
M
N
D
P
N
S
--------------
L
T
---
G
Q
Y
L
---
S
G
K
---------
K
--------------
F
-------------
I
-
P
----
I
P
A
-----------
E
R
R
R
P
D
G
R
W
L
E
V
V
G
A
R
---------
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
---------------
E
V
L
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEH
L
D
-
K
V
I
------
D
I
D
Q
--------------
S
P
IGRTPRSN
P
A
T
----------
Y
T
G
-------------------------------
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTYKG
K
N
I
A
---------------------------------
E
V
--
L
D
M
T
V
-
E
D
------------------------------------------------------------------
A
--------
L
D
--
F
F
A
------------
S
------------------------------
I
P
---
K
--
I
K
R
K
L
E
T
L
Y
----
D
V
G
L
G
Y
----------
M
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
GR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
-
G
D
---
T
----
V
L
V
I
E
H
N
L
D
V
-
I
K
-
T
A
D
Y
I
-
I
D
L
------
G
PEGGDR
G
--
G
Q
I
V
A
-
V
G
T
P
-
E
-
E
V
----------------------------------------------------------------
30
HHSearch
60.27
17%
-111
- C3 -
4Q9H
-
MDR1A_MOUSE
A:
[1028-1258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
-
T
RPS
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
---------------
L
L
E
R
F
Y
D
P
---------------------
M
A
-
G
S
V
------
F
L
D
G
KEIKQLN
V
Q
W
L
---
R
A
---------------------
Q
L
G
-------------------------------
I
V
S
-------------------------------------------------------------------------
Q
E
P
I
-
L
-------------------------------
F
---
D
-
C
S
I
-
A
E
------------------------------------------------------------------
N
--------
I
A
--
Y
G
D
------------
N
S
R
V
---------------------------
V
----
S
--
Y
E
E
I
V
R
A
A
K
----
E
A
N
I
H
Q
F
I
D
S
LPDKYN
T
R
-
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
---
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
E
--
G
R
---
T
----
C
I
V
I
A
H
R
L
S
T
-
I
Q
N
-
A
D
L
I
-
V
V
I
------
Q
------
N
--
G
K
V
K
E
-
H
G
T
H
-
Q
-
Q
L
L
-
A
-------------------------------------------------------------
7
PsiBlast_PDB
59.73
26%
-126
- C3 -
2NQ2
-
Y1470_HAEIN
C:
[2-215]
------------------------------------------------------------------
N
K
A
L
S
V
E
N
L
G
F
Y
Y
Q
A
-
E
-------
N
F
L
F
Q
--------
Q
L
N
F
D
L
-
N
K
G
D
-
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
---------------
L
-------------------------
G
I
H
R
P
I
Q
G
--
K
I
EVYQSIGFVPQFFSSPF
A
--
Y
----------
S
V
L
D
--------------
I
--
V
------
L
M
G
R
--------------------
S
--------------------------
T
H
---
I
-------
N
------------------
T
F
A
KPKSH
D
Y
-------------
Q
--------------------
V
-------------
A
----------
M
-
Q
A
L
DY
L
N
L
T
H
---
L
----
A
---
K
R
E
F
T
S
L
------------------------------------------
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
E
C
--
K
--
L
I
L
L
D
E
P
T
S
A
L
D
LANQ
D
I
V
L
S
L
L
I
D
L
A
Q
S
Q
---
N
M
T
V
V
F
T
T
H
Q
-------
P
N
Q
V
V
A
I
------
A
N
K
T
L
L
L
N
K
Q
N
F
----
K
F
G
E
T
R
N
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
59.32
26%
-108
* C3 *
4YER
4
?
A:
[3-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
I
V
V
E
N
L
V
K
K
F
G
-
D
---
F
E
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
---------------
M
L
T
T
L
L
K
P
---------------------
T
S
-
G
K
A
------
W
V
A
G
HDVLKE
P
R
E
V
----
R
R
---------------------
K
I
G
-------------------------------
I
V
F
-------------------------------------------------------------------------
Q
D
Q
S
---------------------------------
L
D
--
R
E
L
T
A
-
Y
E
------------------------------------------------------------------
N
--------
M
Y
--
I
H
G
------------
K
I
Y
G
---------------------------
Y
G
G
E
K
L
--
K
K
R
I
L
E
L
L
E
----
F
V
E
L
L
E
-----------
F
-
K
D
K
P
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
---
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
EH
N
M
---
T
----
I
F
L
T
T
H
Y
M
D
E
-
A
E
Q
L
A
D
R
V
-
A
I
I
------
D
------
H
--
G
K
I
I
A
L
-
G
T
P
-
T
-
E
-----------------------------------------------------------------
50
Fugue
58.83
21%
-50
- C3 -
1YQT
4
?
A:
[24-538]
-----------------------------------------------------------------
E
E
D
C
V
H
R
Y
G
----------------
V
N
A
F
V
--------
L
Y
R
L
P
V
-
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
GQLIPNLCGDNDS
W
D
-------------------------
G
V
I
R
A
F
R
G
--
N
E
-----------------
L
--
Q
----------
N
Y
F
E
--------------
K
--
L
K
N
GE
I
R
P
V
V
K
--------------------
P
QYVDLIPKAVKGK
V
------------
I
E
---
L
-------
L
------------------
K
K
A
-----
D
E
-------------
T
--------------------
G
-------------
K
----------
L
-
E
E
V
--
V
K
A
L
E
---
L
----
E
NVL
E
R
E
I
Q
H
L
------------------------------------------
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
--
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
-
R
L
N
A
A
R
A
I
R
R
L
S
E
E
---
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
G
V
Y
G
I
F
--------------
S
Q
P
K
G
T
R
N
G
I
N
E
F
L
R
------------------------------------------------
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
K
F
T
K
T
G
E
R
V
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
-
S
----
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
--------------
L
A
G
V
E
E
-
P
---------------------
T
E
-
G
K
I
--------
E
W
--------------
D
L
---------------------
T
V
A
-------------------------------
Y
K
P
-------------------------------------------------------------------------
Q
Y
I
K
-
A
-------------------------------
D
Y
--
E
G
T
V
Y
-
E
L
------------------------------------------------------------------
L
--------
S
K
--
I
D
A
------------
S
------------------------------
K
----
L
N
S
N
F
Y
K
T
E
L
L
K
----
P
L
G
I
I
D
----------
L
Y
-
D
R
E
V
N
E
-
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
---
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
---
E
K
N
E
K
T
----
A
L
V
V
E
H
D
-
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
------
G
------
E
--
P
G
K
Y
G
R
A
L
P
P
M
G
M
R
E
G
M
N
-------------------
R
F
L
A
S
I
G
I
T
F
R
R
D
P
D
T
G
R
P
R
A
N
K
E
G
S
V
K
D
R
E
Q
K
E
K
GEYYYIA
47
HHSearch
56.88
24%
-104
- C3 -
1OXX
21
?
K:
[2-230]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
K
V
F
K
-
K
GK-
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
---------------
I
I
A
G
L
D
V
P
---------------------
S
T
-
G
E
L
------
Y
F
D
D
RLVASNGKLIVPPE
D
R
---------------------
K
I
G
-------------------------------
M
V
F
-------------------------------------------------------------------------
Q
T
W
A
---------------------------------
L
Y
--
P
N
L
T
A
-
F
E
------------------------------------------------------------------
N
--------
I
A
--
F
P
L
------------
T
NMKMSKE-----------------------
E
----
I
--
R
K
R
V
E
E
V
A
K
----
I
L
D
I
H
-----------
H
V
-
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
---
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
QSRL
G
V
---
T
----
L
L
V
V
S
H
D
P
A
D
-
I
F
A
I
A
D
R
V
-
G
V
L
------
V
------
K
--
G
K
L
V
Q
V
G
K
P
E
-
D
-
L
Y
D
---------------------------------------------------------------
44
HHSearch
56.80
24%
-114
- C3 -
3FVQ
3
FBPC_NEIG1
A:
[3-228]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
H
I
G
H
L
S
K
S
F
Q
-
N
---
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
---------------
C
L
A
G
F
E
Q
P
---------------------
D
S
-
G
E
I
------
S
L
S
G
KTIFSKN
T
N
L
P
VR-
E
R
---------------------
R
L
G
-------------------------------
Y
L
V
-------------------------------------------------------------------------
Q
E
G
V
---------------------------------
L
F
--
P
H
L
T
V
-
Y
R
------------------------------------------------------------------
N
--------
I
A
--
Y
G
L
------------
G
NGKGRT
A
-----------------------
Q
----
E
--
R
Q
R
I
E
A
M
L
E
----
L
T
G
I
S
E
-----------
L
-
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
---
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
---
S
----
A
V
F
V
S
H
D
R
E
E
-
A
L
Q
Y
A
D
R
I
-
A
V
M
------
K
------
Q
--
G
R
I
L
Q
T
A
S
P
----------------------------------------------------------------------
37
HHSearch
56.68
20%
-58
- C3 -
3PIH
4
UVRA_THEMA
A:
[355-899]
------------------------------------------------------------------------------------------
V
P
K
V
Q
--------
R
W
H
R
E
T
----
E
-
M
K
E
W
L
E
K
N
F
I
V
Q
R
T
C
S
V
C
G
---------------
G
-------------------------
R
R
L
N
R
E
A
L
--
S
V
K----------------
I
--
N
----------
G
-
L
N
--------------
I
--
H
------
E
F
T
E
--------------------
L
--------------------------
S
I
S
--
E
E
L
-----
E
------------------
F
L
K
-----
N
L
NLT
E
R
E
R
E
I
V
G
E
L
L
--------------------
K
E
I
E
----------
K
----------
R
-
L
E
F
--
L
V
D
V
G
---
L
EYLT
L
---
S
R
S
A
T
T
L
------------------------------------------
S
G
G
E
S
Q
R
I
R
L
A
T
Q
I
G
S
G
L
--
T
G
V
I
Y
V
L
D
E
P
T
I
G
L
H
----
P
R
D
T
E
R
L
I
K
T
L
K
K
L
R
D
L
G
N
T
V
I
V
V
E
H
D
E
E
V
I
R
-
N
A
D
H
I
I
D
I
G
PGGGT
N
G
G
R
V
V
F
Q
-
G
T
V
D
E
L
L
K
N
P
D
S
--------------
S
L
--
T
G
E
Y
----
L
-----------
S
--------------
G
---
K
----
R
---
K
I
----
T
-
V
N
------------
K
T
R
R
L
P
Y
A
S
L
K
I
K
G
V
R
---------
H
N
N
L
K
N
I
D
V
E
I
P
L
G
V
F
V
C
V
T
G
V
S
G
S
G
K
S
S
L
V
M
ET
L
Y
P
A
L
M
N
L
L
HK
T
K
L
P
A
G
E
F
D
S
---------------------
I
E
-
G
H
E
NID
K
M
I
A
I
D
Q
--------------
S
P
IGRTPRSN
P
A
T
Y
T
K
V
F
D
E
I
R
S
L
F
A
M
T
P
A
A
K
A
R
GYNKSRFSFNLKGGRCEACQGQG
Y
V
K
-------------------------------------------------------------------------
I
E
M
L
-
F
L
P
D
V
Y
V
E
CDVCKGKRYN
R
E
T
L
E
ITYKGKN
I
S
D
I
--
L
D
M
T
V
-
D
E
------------------------------------------------------------------
A
--------
L
E
--
F
F
K
------------
N
I-----------------------------
P
----
S
--
I
K
R
T
L
Q
V
L
H
----
D
V
G
L
G
Y
----------
V
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
I
K
L
A
S
E
L
R
K
R
D
T
G
R
T
L
Y
I
L
D
E
P
T
V
G
L
H
F
E
D
V
R
K
L
V
E
V
L
H
R
L
V
D
R
-
G
N
---
T
----
V
I
V
I
E
H
N
L
D
V
-
I
K
-
N
A
D
H
I
-
I
D
L
G
PEGGK
E
------
G
--
G
Y
I
V
A
-
T
G
T
P
-
E
-
E
-----------------------------------------------------------------
49
HHSearch
56.00
23%
-111
- C3 -
2YYZ
3
?
A:
[2-216]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
I
R
V
V
N
L
K
K
Y
F
G
-
K
---
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
---------------
M
L
A
G
I
Y
K
P
---------------------
T
S
-
G
E
I
------
Y
F
D
D
VLVNDIPPK-----
Y
R
---------------------
E
V
G
-------------------------------
M
V
F
-------------------------------------------------------------------------
Q
N
Y
A
---------------------------------
L
Y
--
P
H
M
T
V
-
F
E
------------------------------------------------------------------
N
--------
I
A
--
F
P
L
------------
R
ARRISKD-----------------------
E
----
V
--
E
K
R
V
V
E
I
A
R
----
K
L
L
I
D
-----------
N
L
-
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
---
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
---
T
----
S
V
Y
V
T
H
D
Q
A
E
-
A
M
T
M
A
S
R
I
-
A
V
F
------
N
------
Q
--
G
K
L
V
Q
Y
G
------------------------------------------------------------------------
46
HHSearch
55.68
25%
-106
- C3 -
2IT1
-
?
A:
[3-222]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
K
L
E
N
I
V
K
K
F
G
-
N
---
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
---------------
T
I
A
G
I
Y
K
P
---------------------
T
S
-
G
K
I
------
Y
F
D
E
KDVTELPPK-----
D
R
---------------------
N
V
G
-------------------------------
L
V
F
-------------------------------------------------------------------------
Q
N
W
A
---------------------------------
L
Y
--
P
H
M
T
V
-
Y
K
------------------------------------------------------------------
N
--------
I
A
--
F
P
L
------------
E
L
R
KAP
R
E
-----------------------
E
----
I
--
D
K
K
V
R
E
V
A
K
----
M
L
H
I
D
K
-----------
L
-
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
---
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
---
T
----
T
V
Y
V
T
H
D
Q
A
E
-
A
L
A
M
A
D
R
I
-
A
V
I
------
R
------
E
--
G
E
I
L
Q
V
G
T
P
D
-
E
-
V
Y
----------------------------------------------------------------