@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu05910: (2016-06-09 )
MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTFTKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGVCLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------.......------..10.-----------------...-----....20...--------..-----.-----..30........40........50........60-------........70.--...-....80-----.---------.....--..----------------.90...-.....100.......110.......120.......-130.......140.......150......----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------MKQ
L
K
W
R
------TV
N
P
E
-----------------
E
T
K
-----
A
I
A
K
L
T
A
A
F--------AK-----P-----G
D
V
L
T
L
EGDLGAGK
T
T
F
T
K
G
F
A
EGLG
I
T
R
IVNSP-------
T
F
T
I
I
K
EYNDG--
V
L
P
-
L
Y
H
M
D
------
V
---------
Y
RMED--ES----------------EDLGL
D
-
E
YFHGQG
V
C
L
V
E
W
A
H
L
I
E
E
QL
P
Q
E
R
L
Q
I
V
I
K
RAGD-DE
R
E
I
T
F
T
AVG
N
R
Y
E
M
L
C
E
E
L
S
RHDNISN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
94.94
33%
-136
- C3 -
1HTW
5
TSAE_HAEIN
A:
[1-158]
-------------------------------------------------------------------------------------------------------------------
M
E
S
L
T
Q
Y
------
I
P
D
E
F
-----------------
S
M
L
-----
R
F
G
K
K
F
A
E
I
--------
L
L
-----
K
L
HTE
K
A
I
M
V
Y
L
N
G
D
L
G
A
G
K
T
T
L
T
R
G
M
L
Q
G
I
G
H
Q
G
N
V
K
S
P
-------
T
Y
T
L
V
E
E
Y
N
I
A
--
G
K
M
-
I
Y
H
F
D
------
L
---------
Y
R
L
A
D
P
E
E
L
----------------
E
F
M
G
I
R
-
D
Y
F
N
T
D
S
I
C
L
I
E
W
S
E
K
G
Q
G
I
L
P
E
A
D
I
L
V
N
I
D
Y
Y
D
D
--
A
R
N
I
E
L
I
A
Q
T
N
L
G
K
N
I
I
S
A
F
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
88.08
33%
-131
- C3 -
1HTW
5
TSAE_HAEIN
A:
[1-155]
-------------------------------------------------------------------------------------------------------------------
M
E
S
L
T
Q
Y
------
I
P
D
E
F
-----------------
S
M
L
R
F
G
K
K
F
A
E
I
L
L
K
L
H
--------
T
E
-----
K
-----
A
I
M
V
Y
L
N
G
D
L
G
A
G
K
T
T
L
T
R
G
M
L
Q
G
I
G
H
Q
G
N
V
K
S
P
-------
T
Y
T
L
V
E
E
Y
N
I
A
--
G
K
M
-
I
Y
H
F
D
------
L
---------
Y
R
L
A
D
P
E
E
L
----------------
E
F
M
G
I
R
-
D
Y
F
N
T
D
S
I
C
L
I
E
W
S
E
K
G
Q
G
I
L
P
E
A
D
I
L
V
N
I
D
Y
Y
-
D
-
D
A
R
N
I
E
L
I
A
Q
T
N
L
G
K
N
I
I
S
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.42
40%
-144
- C3 -
1HTW
5
TSAE_HAEIN
A:
[35-147]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
Y
L
N
G
D
L
G
A
G
K
T
T
L
T
R
G
M
L
Q
G
I
G
H
Q
G
N
V
K
S
P
-------
T
Y
T
L
V
E
E
Y
N
I
A
--
G
K
M
-
I
Y
H
F
D
------
L
---------
Y
R
L
A
D
P
E
E
L
----------------
E
F
M
G
I
R
-
D
Y
F
N
T
D
S
I
C
L
I
E
W
S
E
K
G
Q
G
I
L
P
E
A
D
I
L
V
N
I
D
Y
Y
-
D
-
D
A
R
N
I
E
L
I
A
Q
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
79.22
40%
-139
- C3 -
1HTW
3
TSAE_HAEIN
B:
[35-147]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
Y
L
N
G
D
L
G
A
G
K
T
T
L
T
R
G
M
L
Q
G
I
G
H
Q
G
N
V
K
S
P
-------
T
Y
T
L
V
E
E
Y
N
I
A
--
G
K
M
-
I
Y
H
F
D
------
L
---------
Y
R
L
A
D
PE
E
L
----------------
E
F
M
G
I
R
-
D
Y
F
N
T
D
S
I
C
L
I
E
W
S
E
K
G
Q
G
I
L
P
E
A
D
I
L
V
N
I
D
Y
Y
-
D
-
D
A
R
N
I
E
L
I
A
Q
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.38
40%
-128
- C3 -
1FL9
1
TSAE_HAEIN
B:
[38-150]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
Y
L
N
G
D
L
G
A
G
K
T
T
L
T
R
G
M
L
Q
G
I
G
H
Q
G
N
V
K
S
P
-------
T
Y
T
L
V
E
E
Y
N
I
A
--
G
K
M
-
I
Y
H
F
D
------
L
---------
Y
R
L
A
D
PE
E
L
----------------
E
F
M
G
I
R
-
D
Y
F
N
T
D
S
I
C
L
I
E
W
S
E
K
G
Q
G
I
L
P
E
A
D
I
L
V
N
I
D
Y
Y
-
D
-
D
A
R
N
I
E
L
I
A
Q
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.14
40%
-128
- C3 -
1HTW
3
TSAE_HAEIN
C:
[35-147]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
Y
L
N
G
D
L
G
A
G
K
T
T
L
T
R
G
M
L
Q
G
I
G
H
Q
G
N
V
K
S
P
-------
T
Y
T
L
V
E
E
Y
N
I
A
--
G
K
M
-
I
Y
H
F
D
------
L
---------
Y
R
L
A
D
PE
E
L
----------------
E
F
M
G
I
R
-
D
Y
F
N
T
D
S
I
C
L
I
E
W
S
E
K
G
Q
G
I
L
P
E
A
D
I
L
V
N
I
D
Y
Y
-
D
-
D
A
R
N
I
E
L
I
A
Q
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.63
40%
-107
- C3 -
1FL9
1
TSAE_HAEIN
A:
[38-150]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
Y
L
N
G
D
L
G
A
G
K
T
T
L
T
R
G
M
L
Q
G
I
G
H
Q
G
N
V
K
S
P
-------
T
Y
T
L
V
E
E
Y
N
I
A
--
G
K
M
-
I
Y
H
F
D
------
L
---------
Y
R
L
A
D
P
E
E
L
----------------
E
F
M
G
I
R
-
D
Y
F
N
T
D
S
I
C
L
I
E
W
S
E
K
G
Q
G
I
L
P
E
A
D
I
L
V
N
I
D
Y
Y
-
D
-
D
A
R
N
I
E
L
I
A
Q
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.47
40%
-116
- C3 -
1FL9
1
TSAE_HAEIN
C:
[38-150]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
Y
L
N
G
D
L
G
A
G
K
T
T
L
T
R
G
M
L
Q
G
I
G
H
Q
G
N
V
K
S
P
-------
T
Y
T
L
V
E
E
Y
N
I
A
--
G
K
M
-
I
Y
H
F
D
------
L
---------
Y
R
L
A
D
PE
E
L
----------------
E
F
M
G
I
R
-
D
Y
F
N
T
D
S
I
C
L
I
E
W
S
E
K
G
Q
G
I
L
P
E
A
D
I
L
V
N
I
D
Y
Y
-
D
-
D
A
R
N
I
E
L
I
A
Q
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
64.65
21%
-81
- C3 -
3M6A
1
LON1_BACSU
A:
[7-531]
----------------------------------------------TGEVQ
T
L
T
E
K
I
E
EAGMPDHVK
E
T
A
L
K
E
L
N
R
YEKIPSSS
A
E
S
S
V
IRN
Y
I
D
W
L
V
A
LPWTDETD
D
K
L
D
LKE
A
G
R
L
L
D
E
E
------
H
H
G
L
E
-----------------
K
V
K
-----
E
R
I
L
E
Y
L
A
V
--------
Q
K
L
T
KSL
K
-----
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
L
-------
G
G
R
I
I
Q
G
M
K
K
A
GK
L
N
P
-
V
F
L
L
D
------
E
---------
I
D
K
M
S
--
A
M
----------------
L
E
V
L
D
P
-
E
Q
---------------
N
S
S
F
S
D
H
Y
I
E
E
-----
T
F
-
D
L
S
K
V
L
F
I
A
T
A
N
N
L
----------
A
T
I
P
G
P
L
R
D
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
DH
L
L
P
K
Q
I
K
E
H
GLKKSN
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
YTREAGV
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
AEERK
R
I
T
V
T
EKNLQDFIGKRIFRYGQA
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
TV
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
KLG
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
KTEELGIEPDFHEK
Y
D
I
H
I
H
V
P
E
GAVPKDGPAA
G
I
T
M
A
T
A
L
V
S
A
L
T
GRAVSRE
V
G
M
T
G
E
I
T
LRG
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
GLT
T
I
I
A
P
KDNEKDIEDIP
E
S
V
R
E
G
LT
F
I
L
A
SH
L
D
E
V
L
E
H
A
L
V
36
Fugue
53.38
16%
-109
- C3 -
1JR3
2
DPO3X_ECOLI
A:
[3-368]
-----------------------------------------------------------------------------------------------------------------YQ
V
L
A
R
K
W
R
PQTFAD
V
V
G
Q
E
-----------------
H
V
L
-----
T
A
L
A
N
G
L
S
L
--------
G
R
-----
I
-----
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
PCG----
V
C
D
N
C
R
E
I
E
Q
G
--
R
F
V
D
L
I
E
I
D
AASRTK
V
---------
E
D
T
R
D
--
L
L
----------------
D
N
V
Q
Y
A
-
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
----
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
-
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
EGS
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
DGQVS
T
Q
A
V
S
A
M
L
GTLD
D
D
Q
A
L
S
L
V
E
A
M
V
E
AN
G
E
R
V
M
A
L
I
N
E
A
A
A
R
GIE
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
SPAALGNDMAAI
E
L
R
M
R
E
L
A
R
T
IP
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
PYAPD
R
R
M
G
V
E
M
T
L
L
R
A
L
A
F
HPRMPLPEP--------------------------------------------------------------------------------------------------
34
Fugue
52.60
16%
-106
- C3 -
1A5T
1
?
?:
[1-172]
-------------------------------------------------------------------------------------------------------------------
M
R
W
Y
P
W
L
------
R
P
D
F
E
-----------------
K
L
V
-----
A
S
Y
Q
A
------------
G
R
-----
G
-----
H
H
A
L
L
I
Q
A
L
P
G
M
G
D
D
A
L
I
Y
A
L
S
R
Y
L
L
C
Q
Q
P
Q
G
H
K
SCGHC
R
G
C
Q
L
M
Q
A
G
T
H
P
D
--
Y
Y
T
-
L
A
P
E
K
GKNTLG
V
---------
D
A
V
R
E
--
V
T
----------------
E
K
L
N
E
H
-
A
R
L
G
G
A
K
V
V
W
V
T
D
A
A
L
----
L
T
D
A
A
A
N
A
L
L
K
T
L
E
E
-
P
P
A
E
T
W
F
F
L
A
T
R
E
P
E
R
L
L
A
T
L
R
S
R
C
R
L
H
Y
LAP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
46.20
30%
-143
- C3 -
3GD7
1
CFTR_HUMAN (first)
A:
[34-73]
--------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----
A
I
L
E
N
I
S
F
S
--------
I
S
-----
P
-----
G
Q
R
V
G
L
L
G
R
T
G
S
G
K
S
T
L
L
S
A
F
L
R
L
L
N
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
45.55
18%
-116
- C3 -
4XGU
1
PCH2_CAEEL
A:
[4-424]
P
M
K
T
L
K
N
I
H
A
E
I
R
I
C
QKFP
K
S
T
V
Q
K
R
F
S
E
F
E
E
L
I
K
A
A
S
K
N
ARNWKPISLNELFE
K
L
V
I
G
T
CELRDGELFEND
L
T
I
N
PSN
I
H
V
Y
K
L
H
KDGPLSS
Q
L
W
Q
L
PCV
E
F
D
S
I
W
ENLIYDSN
L
K
N
E
V
M
S
------
Y
V
A
A
L
-----------------
A
R
L
-----
S
E
K
H
V
N
T
K
I
--------
I
N
-----
V
-----
N
R
L
I
L
L
T
G
P
P
G
T
G
K
T
S
L
C
K
G
L
A
Q
H
L
S
I
R
M
N
D
K
Y
S
-------
K
S
V
M
L
E
I
N
S
H
S
--
L
F
S
------------------------------------------------------
K
W
F
S
E
S
G
K
L
V
Q
K
M
F
D
Q
I
D
E
L
A
E
--------------
D
E
K
C
M
V
F
V
L
I
D
E
V
I
R
A
V
N
A
L
L
T
Q
I
D
R
I
R
R
RDN
V
L
I
L
C
T
S
NLESTLD
K
A
L
V
D
R
AD
I
V
K
N
V
G
QPS
D
F
A
R
Y
S
M
L
K
S
S
I
M
E
L
A
R
I
GVVIDNEVHTDYWPQDICDTKAPRN
E
F
T
E
I
L
F
K
I
A
Q
E
A
RGLS
G
R
A
I
S
M
L
P
T
L
V
Y
S
K
SPEETIT
L
P
N
C
M
N
L
F
L
E
A
V
K
E
R
L
S
R
N
N-------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
44.69
24%
-171
- C3 -
5C78
1
PGLK_CAMJE
A:
[362-402]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
Y
L
F
K
N
L
N
L
N
--------
I
K
-----
K
-----
G
E
K
I
A
F
I
G
E
S
G
C
G
K
S
T
L
V
D
L
I
I
G
L
L
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
44.42
19%
-53
- C2 -
4QT6
11
A:
[1-157]
--------------------------------------------------------------------------------------------------------------------------------
G
F
D
P
E
-----------------
K
A
Q
-----
C
------
C
L
--------
V
E
-----
N
-----
G
Q
I
L
T
H
-
G
S
G
G
K
G
-----
Y
G
L
A
S
T
-
G
V
T
S
G
C
Y
Q
W
-------
K
F
Y
I
V
K
E
N
R
G
N
--
E
G
T
-
C
V
G
V
S
------
R
---------
W
P
V
H
D
--
F
N
----------------
H
R
T
T
S
D
M
W
L
Y
R
A
Y
S
G
N
L
Y
H
-
N
G
E
Q
T
L
T
L
S
S
F
T
Q
G
D
F
I
T
C
V
L
D
M
E
A
R
T
I
S
F
G
K
N
G
E
E
P
K
L
A
F
E
D
V
D
A
A
E
L
Y
P
C
V
M
F
YSSN
P
G
E
K
V
K
I
C
D
MQMR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
44.11
23%
-168
- C3 -
4PL0
2
MCJD_ECOLX
A:
[359-398]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
N
S
V
S
L
D
--------
L
F
-----
T
-----
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
I
I
S
G
Y
Y
K
N
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
43.95
28%
-141
* C3 *
4FIN
4
ETTA_ECOLI
A:
[19-68]
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
H
I
L
K
N
I
S
L
S
--------
F
F
-----
P
-----
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
42.10
15%
-50
- C1 -
3D30
4
YOAJ_BACSU
A:
[1-208]
-------------------------------------------------------------------------------------------------------------------
M
A
Y
D
D
L
H
------
E
G
Y
A
T
Y
T
GSGYSGGAFLLDPIP
S
D
M
-----
E
I
T
A
I
N
P
A
D
L
N
YGGVKA
A
L
-----
A
-----
G
S
Y
L
E
V
E
G
P
K
G
K
T
T
V
Y
V
T
D
L
Y
P
E
G
A
R
G
A
L
D
L
S
P
N
-------
A
F
R
K
I
G
N
M
K
D
G
--
K
I
N
-
I
K
W
R
V
------
V
K
A
P
I
T
G
N
F
T
Y
R
I
K
E
--
G
S
SRW
W
A
A
I
Q
V
R
NHKYPV
M
K
M
E
Y
E
-
K
D
G
K
W
I
N
M
E
K
M
D
Y
N
H
F
V
S
T
N
L
G
T
G
S
L
K
V
R
M
T
D
I
R
G
-
K
V
V
K
D
T
I
P
K
L
P
E
S
G
T
S
K
A
Y
T
V
P
G
H
V
Q
F
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
41.84
20%
-107
- C3 -
4Q4H
-
?
A:
[346-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
P
V
L
S
G
V
N
F
S
--------
V
K
-----
P
-----
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
40.73
20%
-142
- C3 -
4MRS
1
ATM1_NOVAD
A:
[375-414]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
H
G
L
S
F
E
--------
V
A
-----
A
-----
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------