@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu05940: (2016-06-09 )
MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKRFGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAKALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIGETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGLKSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVAANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQPGLELTSYQSLTR
Atome Classification :
(24 SA)
.........10........20...-.....30........40..-......50........60........70........80........90........100.......110.......120.....--..130-.--.-.......140......-.150.......160.......170.......180.......190...-.-..-.-------------200.......210.......220.......230.......----240.......250....-----...260.......270.......280.......290......---.300.......310.......320......-.330-.......340....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEQK
D
M
Y
V
L
G
IETS
C
D
E
T
A
A
A
I
V
-KN
G
K
E
I
I
S
N
V
V
A
S
Q
I
E
S
H
K
-RFGGV
V
P
E
I
A
SR
H
H
V
E
Q
I
T
L
V
I
E
E
A
F
R
KAGMTYSD
I
D
A
I
A
VTEGP
G
L
V
G
A
L
L
IGV
N
A
A
K
A
L
S
F
AYNIP
L
V
G
V
H
H
I
A
G
H
I
Y
A
N
R
L
--
V
E
D
---
I
--
V
-
F
P
A
L
A
L
V
VSGG
H
T
E
L
V
-
Y
M
KEHG
S
F
E
V
I
G
E
T
L
D
D
AA
G
E
A
Y
D
K
V
A
R
TMGLPYPGGP
Q
I
D
K
L
A
EKG-N-DN-I-------------PL
P
R
A
W
L
EEGSYNF
S
F
S
G
L
K
S
A
V
I
N
T
L
H
NASQKGQEI
A
P
E
----
D
L
S
A
S
F
Q
N
S
V
I
D
V
L
V
T
K
-----
T
A
R
A
A
K
E
Y
D
V
K
Q
V
L
L
AGGVAAN
R
G
L
R
A
A
L
E
K
E
F
A
QHE
G
I
T
L
V---IPPLALCTDN
A
A
M
I
A
A
A
G
T
I
A
F
E
KGIRGAY-DMNG-QPG
L
E
LT
S
Y
QSLTR
2
PsiBlast_PDB
81.92
45%
-115
- C2 -
3ZEU
4
?
B:
[1-317]
------
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
-
T
A
G
R
-
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
--
S
N
G
G
D
E
Q
T
R
A
----
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
E
S
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
---
A
R
P
-
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
------------------------
21
PsiBlast_CBE
81.72
45%
-119
- C2 -
3ZEU
4
?
E:
[1-317]
------
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
-
T
A
G
R
-
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
--
S
N
G
G
D
E
Q
T
R
A
----
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
E
S
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
---
A
R
P
-
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
------------------------
5
PsiBlast_PDB
81.66
44%
-116
- C2 -
4WQ5
5
TSAD_ECOLI
A:
[1-316]
------
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
-
T
A
G
R
-
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
G
T
D
D
Q
T
R
A
------
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
---
A
R
P
-
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
-------------------------
1
PsiBlast_PDB
81.32
45%
-115
- C2 -
3ZET
2
?
B:
[1-317]
------
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
-
T
A
G
R
-
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
--
S
N
G
G
D
E
Q
T
R
A
----
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
E
S
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
---
A
R
P
-
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
------------------------
4
PsiBlast_PDB
81.25
44%
-120
- C2 -
4WQ4
3
TSAD_ECOLI
A:
[1-316]
------
M
R
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
-
T
A
G
R
-
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
G
T
D
D
Q
T
R
A
------
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
---
A
R
P
-
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
-------------------------
23
PsiBlast_CBE
81.05
44%
-117
- C2 -
4WQ4
4
TSAD_ECOLI
B:
[1-316]
------
M
R
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
-
T
A
G
R
-
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
G
T
D
D
Q
T
R
A
------
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
---
A
R
P
-
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
-------------------------
3
PsiBlast_PDB
79.45
44%
-112
- C2 -
4YDU
7
TSAD_ECOLI
A:
[1-316]
------
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
-
T
A
G
R
-
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
G
T
D
D
Q
T
R
A
------
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
---
A
R
P
-
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
-------------------------
22
PsiBlast_CBE
79.39
44%
-113
- C2 -
4YDU
7
TSAD_ECOLI
B:
[1-316]
------
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
-
T
A
G
R
-
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
G
T
D
D
Q
T
R
A
------
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
---
A
R
P
-
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
-------------------------
44
HHSearch
78.57
42%
-111
- C2 -
3ZEU
5
?
B:
[1-335]
------
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
PE
F
-
P
F
V
A
L
L
V
S
G
G
H
T
-
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
M
A
S
Q
G
-
T
-
A
G
R
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
S
N
--
G
G
D
E
Q
T
R
A
----
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
E
S
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
-
R
R
G
E
V
F
---
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
-
G
V
T
V
-
R
P
R
W
P
L
A
E
L
P
----
24
PsiBlast_CBE
78.55
44%
-111
- C2 -
4WQ5
4
TSAD_ECOLI
B:
[1-316]
------
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
-
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
L
--
E
D
N
---
P
--
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
M
A
A
Q
G
-
T
A
G
R
-
F
-------------
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
A
N
T
I
R
D
N
G
T
D
D
Q
T
R
A
------
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
---
A
R
P
-
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
-------------------------
6
PsiBlast_PDB
77.26
38%
-126
- C2 -
2IVN
3
KAE1_PYRAB
A:
[1-302]
------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
-
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
V
K
D
---
P
--
V
-----
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
-
E
G
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
-
E
-
K
Y
-
I
-------------
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
Y
R
-----
V
E
----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
------------------------
8
PsiBlast_PDB
77.02
38%
-126
- C2 -
2IVP
2
KAE1_PYRAB
A:
[1-302]
------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
-
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
V
K
D
---
P
--
V
-----
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
-
E
G
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
-
E
-
K
Y
-
I
-------------
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
Y
R
-----
V
E
----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
------------------------
27
PsiBlast_CBE
76.88
38%
-129
- C2 -
2IVO
2
KAE1_PYRAB
B:
[1-302]
------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
-
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
FG
V
K
D
---
P
--
V
-----
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
-
E
G
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
-
E
-
K
Y
-
I
-------------
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
Y
R
-----
V
E
----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
------------------------
26
PsiBlast_CBE
76.84
38%
-125
- C2 -
2IVO
3
KAE1_PYRAB
C:
[1-302]
------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
-
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
FG
V
K
D
---
P
--
V
-----
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
-
E
G
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
-
E
-
K
Y
-
I
-------------
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
Y
R
-----
V
E
----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
------------------------
7
PsiBlast_PDB
76.53
38%
-127
- C2 -
2IVO
3
KAE1_PYRAB
A:
[1-302]
------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
-
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
V
K
D
---
P
--
V
-----
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
-
E
G
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
-
E
-
K
Y
-
I
-------------
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
Y
R
-----
V
E
----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
------------------------
34
Fugue
76.10
36%
-115
- C2 -
2IVN
3
KAE1_PYRAB
A:
[1-325]
------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
-
V
L
A
N
V
F
D
T
L
---
T
T
-
E
K
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
G
V
--------
K
D
P
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
-
E
-
K
Y
-
I
-------------
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
Y
R
-----
V
E
----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
-
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
S
F
R
L
-
E
E
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
V
W
H
25
PsiBlast_CBE
75.38
38%
-128
- C2 -
2IVO
2
KAE1_PYRAB
D:
[1-302]
------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
D
K
-
V
L
A
N
V
F
D
T
-
L
T
T
E
K
---
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
FG
V
K
D
---
P
--
V
-----
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
-
E
G
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
-
E
-
K
Y
-
I
-------------
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
K
Y
R
-----
V
E
----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
R
I
M
T
E
D
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
------------------------
46
HHSearch
74.54
36%
-117
- C2 -
2IVN
3
KAE1_PYRAB
A:
[1-320]
------
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
-
S
E
-
D
K
V
L
A
N
V
F
-
D
T
L
T
T
-
E
-
K
G
-
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
--
F
G
V
------
K
-
D
P
V
G
L
Y
V
S
-
G
G
N
T
Q
V
L
-
A
L
E
G
-
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
L
A
E
K
G
-
E
-
K
Y
-
I
-------------
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
R
S
G
-----
K
Y
R
V
E
----
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
-
R
G
I
K
F
F
---
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
S
F
R
L
E
E
T
I
V
-
K
Q
K
F
R
T
D
E
V
-----
29
PsiBlast_CBE
73.69
34%
-121
- C2 -
3EN9
2
KAE1B_METJA
B:
[6-322]
------
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
-
T
S
D
G
E
V
L
F
N
---
K
T
I
M
Y
K
P
----
G
I
N
P
R
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
E
I
G
K
L
--
T
T
E
---
A
--
E
-
D
P
-
L
T
L
Y
V
S
G
G
N
T
Q
V
I
A
Y
V
S
K
--
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
G
G
P
Y
I
E
E
L
A
R
K
G
-
K
-
K
L
-
V
-------------
D
L
P
Y
T
---
V
K
G
M
D
I
A
F
S
G
L
L
T
A
A
M
----
R
A
Y
D
A
G
E
R
L
--
E
----
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
-----
T
E
R
A
L
A
H
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
K
A
M
C
E
G
Q
N
V
D
F
Y
---
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
-------------------------
9
PsiBlast_PDB
72.62
35%
-137
- C2 -
3ENO
1
KAE1B_THEAC
A:
[6-308]
------
M
I
V
L
G
L
E
G
T
A
H
T
I
S
C
G
I
I
-
D
E
-----
S
R
I
L
A
M
E
S
S
M
Y
R
P
K
T
G
G
I
R
P
L
D
A
A
V
H
H
S
E
V
I
D
T
V
I
S
R
A
L
E
K
A
K
I
S
I
H
D
I
D
L
I
G
F
S
M
G
P
G
L
A
P
S
L
R
V
T
A
T
A
A
R
T
I
S
V
L
T
G
K
P
I
I
G
V
N
H
P
L
G
H
I
E
I
G
R
R
--
V
T
G
---
A
--
I
-
D
P
V
M
-
L
Y
V
S
G
G
N
T
Q
V
I
--
A
H
V
N
G
R
Y
R
V
L
G
E
T
L
D
I
G
I
G
N
M
I
D
K
F
A
R
E
A
G
I
P
F
P
G
G
P
E
I
E
K
L
A
M
K
G
-
T
-
K
L
-
L
-------------
D
L
P
Y
S
V
---
K
G
M
D
T
A
F
S
G
I
L
T
A
A
L
Q
Y
L
----
K
T
G
Q
A
I
--
E
----
D
I
S
Y
S
I
Q
E
T
A
F
A
M
L
V
E
V
-----
L
E
R
A
L
Y
V
S
G
K
D
E
I
L
M
A
G
G
V
A
L
N
R
R
L
R
D
M
V
-
T
N
M
A
R
E
A
G
I
R
S
Y
---
L
T
D
R
E
Y
C
M
D
N
G
I
M
I
A
Q
A
A
L
L
M
Y
K
S
G
V
R
-----------------------
11
PsiBlast_PDB
72.51
34%
-129
- C2 -
2VWB
1
KAE1B_METJA
A:
[1-300]
------
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
-
T
S
D
G
E
V
L
F
N
---
K
T
I
M
------------
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
E
I
G
K
L
--
T
T
E
---
A
--
E
-
D
P
-
L
T
L
Y
V
S
G
G
N
T
Q
V
I
A
Y
V
S
K
--
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
G
G
P
Y
I
E
E
L
A
R
K
G
-
K
-
K
L
-
V
-------------
D
L
P
Y
T
---
V
K
G
M
D
I
A
F
S
G
L
L
T
A
A
M
----
R
A
Y
D
A
G
E
R
L
--
E
----
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
-----
T
E
R
A
L
A
H
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
K
A
M
C
E
G
Q
N
V
D
F
Y
---
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
-------------------------
30
PsiBlast_CBE
71.17
34%
-129
- C2 -
2VWB
1
KAE1B_METJA
B:
[1-314]
------
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
-
T
S
D
G
E
V
L
F
N
---
K
T
I
M
------------
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
--
V
D
K
N
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
E
I
G
K
L
--
T
T
E
---
A
--
E
-
D
P
-
L
T
L
Y
V
S
G
G
N
T
Q
V
I
A
Y
V
S
K
--
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
G
G
P
Y
I
E
E
L
A
R
K
G
-
K
-
K
L
-
V
-------------
D
L
P
Y
T
---
V
K
G
M
D
I
A
F
S
G
L
L
T
A
A
M
----
R
A
Y
D
A
G
E
R
L
--
E
----
D
I
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
-----
T
E
R
A
L
A
H
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
-
K
A
M
C
E
G
Q
N
V
D
F
Y
---
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
-------------------------
12
PsiBlast_PDB
67.62
31%
-111
- C2 -
3WUH
2
QRI7_YEAST
A:
[7-363]
----
K
G
Y
K
V
L
A
I
E
T
S
C
D
D
T
C
V
S
V
L
D
R
F
S
K
S
A
A
P
N
V
L
A
N
L
K
D
T
L
D
---------
K
A
H
I
H
H
Q
A
R
I
G
P
L
T
E
R
A
L
I
E
S
N
-
A
R
E
G
I
D
L
I
C
V
T
R
G
P
G
M
P
G
S
L
S
G
G
L
D
F
A
K
G
L
A
V
A
W
N
K
P
L
I
G
V
H
H
M
L
G
H
L
L
I
P
R
M
--
G
T
N
GKV
P
--
Q
-
F
P
F
V
S
L
L
V
S
G
G
H
T
T
F
V
-
L
S
R
A
I
D
D
H
E
I
L
C
D
T
I
D
I
A
V
G
D
S
L
D
K
C
G
R
E
L
G
F
---
K
G
T
M
I
A
R
E
M
E
K
F
I
N
-
Q
D
-
I
NDQDFALKLEMP---------
R
N
M
L
S
F
S
F
S
A
F
I
T
A
L
R
T
N
L
T
K
L
G
K
T
-----
P
E
R
E
I
R
S
I
A
Y
Q
V
Q
E
S
V
F
D
H
I
I
N
K
L
K
H
V
L
K
S
Q
P
E
K
F
K
N
V
R
E
F
V
C
S
G
G
V
S
S
N
Q
R
L
R
T
K
L
E
T
E
L
--------
F
N
F
Y
Y
P
P
M
D
L
C
S
D
N
S
I
M
I
G
W
A
G
-
I
E
I
W
E
S
L
R
L
V
S
-
D
L
D
I
-
C
P
------------
31
PsiBlast_CBE
65.63
31%
-112
- C2 -
3WUH
2
QRI7_YEAST
B:
[7-363]
----
K
G
Y
K
V
L
A
I
E
T
S
C
D
D
T
C
V
S
V
L
D
R
F
S
K
S
A
A
P
N
V
L
A
N
L
K
D
T
L
----------
K
A
H
I
H
H
Q
A
R
I
G
P
L
T
E
R
A
L
I
E
S
N
-
A
R
E
G
I
D
L
I
C
V
T
R
G
P
G
M
P
G
S
L
S
G
G
L
D
F
A
K
G
L
A
V
A
W
N
K
P
L
I
G
V
H
H
M
L
G
H
L
L
I
P
R
M
--
G
T
N
GKV
P
--
Q
-
F
P
F
V
S
L
L
V
S
G
G
H
T
T
F
V
-
L
S
R
A
I
D
D
H
E
I
L
C
D
T
I
D
I
A
V
G
D
S
L
D
K
C
G
R
E
L
G
F
---
K
G
T
M
I
A
R
E
M
E
K
F
I
N
-
Q
D
-
I
NDQDFA
L
K
L
E
M
PS-------
K
R
N
M
L
S
F
S
F
S
A
F
I
T
A
L
R
T
N
L
T
K
L
G
K
T
E
I
Q
E
L
P
E
RE
I
R
S
I
A
Y
Q
V
Q
E
S
V
F
D
H
I
I
N
K
L
K
H
V
L
K
S
Q
P
E
K
F
K
N
V
R
E
F
V
C
S
G
G
V
S
S
N
Q
R
L
R
T
K
L
E
T
E
L
--------
F
N
F
Y
Y
P
P
M
D
L
C
S
D
N
S
I
M
I
G
W
A
G
-
I
E
I
W
E
S
L
R
L
V
S
-
D
L
D
I
-
C
P
------------