@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06150: (2016-06-09 )
MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGICGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGRCEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSVGIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGATHIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQNEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAMERALQFKNECLKVMVYPNR
Atome Classification :
(30 SA)
.........10......-..-20........30.-.-......40........-50........60...--.....70........80........90.......--.100.......110.......-120----------------------...----.....130.......140--.......150...-.-...160...-..-..170.......180.......190.......200.......210.......220..-----...-----.--.230.--......240--.--......250.......260...-....270.......280.-..--.--..---.290...-..----.--.300.---......310.......320.......330.......340..-.....350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTHTVPQ
N
M
K
A
A
V
MHN
T
-
R
E
-
I
K
I
E
TLPVPDI
N
H
-
D
-
E
V
L
I
K
V
M
AVGICGSD
L
-
H
Y
YTNGRIG
N
Y
V
VEK--
P
F
I
LGHECA
G
E
I
A
A
VGSSVDQFKVG
D
R
V
AVEPGV--TCG
R
C
E
A
C
KEGRYNLCPDV
Q
F
-
L
A-----------------------TPP----V
D
G
A
F
V
Q
Y
I
K
MRQ
D
F
V
F
L--IPDSLSY
E
E
AALI-E-
P
F
S
V
GI
H
A
A-AR-TKLQPG
S
T
I
A
I
M
GMG
P
V
G
L
M
A
V
A
A
A
K
AFG
A
G
T
I
I
V
TDLE
P
L
R
L
E
A
A
K
KMGA
T
H
I
I
NI-----
R
E
Q
-----
D
--
A
L
E
E
I
--
K
T
I
TNDRGV--
D
--
V
A
WETAG
N
P
A
A
L
Q
S
A
L
A
S
V
RRG-
G
K
L
A
I
V
GLPSQNEIPLNV-
P
F
--I--AD---N
E
I
D
I
Y
G
-
I
F
----R--YANTY---P
K
G
I
E
F
L
A
SGIVDT
K
H
LVTDQY
S
L
E
Q
T
Q
D
A
M
E
R
A
L
Q
F
K
N
E
C
-
L
K
V
M
VYPNR
136
HHSearch
94.77
42%
-133
- C1 -
1E3J
4
?
A:
[4-350]
-------
D
N
L
S
A
V
L
Y
K
Q
-
N
D
-
L
R
L
E
Q
R
P
I
P
E
P
K
E
-
D
-
E
V
L
L
Q
M
A
Y
V
G
I
C
G
S
D
V
-
H
Y
Y
E
H
G
R
I
A
D
F
I
V
K
D
--
P
M
V
I
G
H
E
A
S
G
T
V
V
K
V
G
K
N
V
K
H
L
K
K
G
D
R
V
A
V
E
P
G
V
--
P
C
R
R
C
Q
F
C
K
E
G
K
Y
N
L
C
P
D
L
T
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
A
R
Y
Y
V
H
A
A
D
F
C
H
K
--
L
P
D
N
V
S
L
E
E
G
A
L
L
-
E
-
P
L
S
V
G
V
H
A
C
-
R
R
-
A
G
V
Q
L
G
T
T
V
L
V
I
G
A
G
P
I
G
L
V
S
V
L
A
A
K
A
Y
G
A
F
-
V
V
C
T
A
R
S
P
R
R
L
E
V
A
K
N
C
G
A
D
V
T
L
V
V
-----
D
P
A
KEE
E
S
S
--
I
I
E
R
I
--
R
S
A
I
-
G
D
L
P
--
N
--
V
T
I
D
C
S
G
N
E
K
C
I
T
I
G
I
N
I
T
R
T
G
-
G
T
L
M
L
V
G
M
G
S
-
Q
M
V
T
V
P
L
-
V
N
--
A
--
C
A
---
R
E
I
D
I
K
S
-
V
F
----
R
--
Y
C
N
D
Y
---
P
I
A
L
E
M
V
A
S
G
R
C
N
V
K
Q
L
V
T
H
S
F
K
L
E
Q
T
V
D
A
F
E
A
A
R
K
K
A
D
N
T
-
I
K
V
M
I
S
C
R
-
1
PsiBlast_PDB
91.50
43%
-134
- C1 -
1E3J
4
?
A:
[7-347]
----------
S
A
V
L
Y
K
Q
-
N
D
-
L
R
L
E
Q
R
P
I
P
E
P
K
E
-
D
-
E
V
L
L
Q
M
A
Y
V
G
I
C
G
S
D
V
-
H
Y
Y
E
H
G
R
I
A
D
F
I
V
K
D
--
P
M
V
I
G
H
E
A
S
G
T
V
V
K
V
G
K
N
V
K
H
L
K
K
G
D
R
V
A
V
E
P
G
V
--
P
C
R
R
C
Q
F
C
K
E
G
K
Y
N
L
C
P
D
L
T
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
A
R
Y
Y
V
H
A
A
D
F
C
H
K
--
L
P
D
N
V
S
L
E
E
G
A
L
L
-
E
-
P
L
S
V
G
V
H
A
C
-
R
R
-
A
G
V
Q
L
G
T
T
V
L
V
I
G
A
G
P
I
G
L
V
S
V
L
A
A
K
A
Y
G
A
-
F
V
V
C
T
A
R
S
P
R
R
L
E
V
A
K
N
C
G
A
D
V
T
L
V
V
DPAKE
E
E
S
-----
S
--
I
I
E
R
I
--
R
S
A
I
G
D
L
P
---
N
--
V
T
I
D
C
S
G
N
E
K
C
I
T
I
G
I
N
I
T
R
T
G
-
G
T
L
M
L
V
G
M
G
S
Q
M
---
V
T
V
-
P
L
--
V
N
A
C
A
---
R
E
I
D
I
K
S
-
V
F
----
R
--
Y
C
N
D
Y
---
P
I
A
L
E
M
V
A
S
G
R
C
N
V
K
Q
L
V
T
H
S
F
K
L
E
Q
T
V
D
A
F
E
A
A
R
K
K
A
D
N
T
-
I
K
V
M
I
----
23
PsiBlast_CBE
89.58
42%
-120
- C1 -
1PL8
2
DHSO_HUMAN
B:
[6-347]
-----
P
N
N
L
-
S
L
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
R
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
E
Y
G
R
I
G
N
F
I
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
E
K
V
G
S
S
V
K
H
L
K
P
G
D
R
V
A
I
E
P
G
A
--
P
R
E
N
D
E
F
C
K
M
G
R
Y
N
L
S
P
S
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
A
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
G
G
V
T
L
G
H
K
V
L
V
C
G
A
G
P
I
G
M
V
T
L
L
V
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
T
R
L
S
K
A
K
E
I
G
A
D
L
V
L
Q
I
-----
S
K
E
-----
S
--
P
Q
E
I
A
--
R
K
V
E
G
Q
L
G
C
KP
E
--
V
T
I
E
C
T
G
A
E
A
S
I
Q
A
G
I
Y
A
T
R
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
T
V
-
P
L
--
L
HA
A
I
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
V
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
---
T
F
K
K
G
L
G
L
K
I
M
L
----
21
PsiBlast_CBE
89.51
42%
-118
- C1 -
1PL8
2
DHSO_HUMAN
D:
[6-347]
-----
P
N
N
L
-
S
L
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
R
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
E
Y
G
R
I
G
N
F
I
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
E
K
V
G
S
S
V
K
H
L
K
P
G
D
R
V
A
I
E
P
G
A
--
P
R
E
N
D
E
F
C
K
M
G
R
Y
N
L
S
P
S
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
A
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
G
G
V
T
L
G
H
K
V
L
V
C
G
A
G
P
I
G
M
V
T
L
L
V
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
T
R
L
S
K
A
K
E
I
G
A
D
L
V
L
Q
I
-----
S
K
E
-----
S
--
P
Q
E
I
A
--
R
K
V
E
G
Q
L
G
C
KP
E
--
V
T
I
E
C
T
G
A
E
A
S
I
Q
A
G
I
Y
A
T
R
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
T
V
-
P
L
--
L
HA
A
I
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
V
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
---
T
F
K
K
G
L
G
L
K
I
M
L
----
3
PsiBlast_PDB
88.19
42%
-118
- C1 -
1PL8
2
DHSO_HUMAN
A:
[6-347]
-----
P
N
N
L
-
S
L
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
R
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
E
Y
G
R
I
G
N
F
I
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
E
K
V
G
S
S
V
K
H
L
K
P
G
D
R
V
A
I
E
P
G
A
--
P
R
E
N
D
E
F
C
K
M
G
R
Y
N
L
S
P
S
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
A
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
G
G
V
T
L
G
H
K
V
L
V
C
G
A
G
P
I
G
M
V
T
L
L
V
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
T
R
L
S
K
A
K
E
I
G
A
D
L
V
L
Q
I
-----
S
K
E
-----
S
--
P
Q
E
I
A
--
R
K
V
E
G
Q
L
G
C
KP
E
--
V
T
I
E
C
T
G
A
E
A
S
I
Q
A
G
I
Y
A
T
R
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
T
V
-
P
L
--
L
H
A
A
I
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
V
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
---
T
F
K
K
G
L
G
L
K
I
M
L
----
26
PsiBlast_CBE
87.75
42%
-116
- C1 -
1PL7
1
DHSO_HUMAN
B:
[6-347]
-----
P
N
N
L
-
S
L
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
R
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
E
Y
G
R
I
G
N
F
I
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
E
K
V
G
S
S
V
K
H
L
K
P
G
D
R
V
A
I
E
P
G
A
--
P
R
E
N
D
E
F
C
K
M
G
R
Y
N
L
S
P
S
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
A
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
G
G
V
T
L
G
H
K
V
L
V
C
G
A
G
P
I
G
M
V
T
L
L
V
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
T
R
L
S
K
A
K
E
I
G
A
D
L
V
L
Q
I
-----
S
K
E
-----
S
--
P
Q
E
I
A
--
R
K
V
E
G
Q
L
G
C
KP
E
--
V
T
I
E
C
T
G
A
E
A
S
I
Q
A
G
I
Y
A
T
R
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
T
V
-
P
L
--
L
HA
A
I
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
V
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
---
T
F
K
K
G
L
G
L
K
I
M
L
----
24
PsiBlast_CBE
87.70
42%
-119
- C1 -
1PL7
1
DHSO_HUMAN
D:
[6-347]
-----
P
N
N
L
-
S
L
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
R
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
E
Y
G
R
I
G
N
F
I
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
E
K
V
G
S
S
V
K
H
L
K
P
G
D
R
V
A
I
E
P
G
A
--
P
R
E
N
D
E
F
C
K
M
G
R
Y
N
L
S
P
S
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
A
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
G
G
V
T
L
G
H
K
V
L
V
C
G
A
G
P
I
G
M
V
T
L
L
V
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
T
R
L
S
K
A
K
E
I
G
A
D
L
V
L
Q
I
-----
S
K
E
-----
S
--
P
Q
E
I
A
--
R
K
V
E
G
Q
L
G
C
KP
E
--
V
T
I
E
C
T
G
A
E
A
S
I
Q
A
G
I
Y
A
T
R
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
T
V
-
P
L
--
L
HA
A
I
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
V
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
---
T
F
K
K
G
L
G
L
K
I
M
L
----
2
PsiBlast_PDB
87.28
42%
-117
- C1 -
1PL7
1
DHSO_HUMAN
A:
[6-347]
-----
P
N
N
L
-
S
L
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
R
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
E
Y
G
R
I
G
N
F
I
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
E
K
V
G
S
S
V
K
H
L
K
P
G
D
R
V
A
I
E
P
G
A
--
P
R
E
N
D
E
F
C
K
M
G
R
Y
N
L
S
P
S
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
A
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
G
G
V
T
L
G
H
K
V
L
V
C
G
A
G
P
I
G
M
V
T
L
L
V
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
T
R
L
S
K
A
K
E
I
G
A
D
L
V
L
Q
I
-----
S
K
E
-----
S
--
P
Q
E
I
A
--
R
K
V
E
G
Q
L
G
C
KP
E
--
V
T
I
E
C
T
G
A
E
A
S
I
Q
A
G
I
Y
A
T
R
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
T
V
-
P
L
--
L
H
A
A
I
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
V
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
---
T
F
K
K
G
L
G
L
K
I
M
L
----
22
PsiBlast_CBE
87.16
42%
-118
- C1 -
1PL8
2
DHSO_HUMAN
C:
[6-347]
-----
P
N
N
L
-
S
L
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
R
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
E
Y
G
R
I
G
N
F
I
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
E
K
V
G
S
S
V
K
H
L
K
P
G
D
R
V
A
I
E
P
G
A
--
P
R
E
N
D
E
F
C
K
M
G
R
Y
N
L
S
P
S
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
A
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
G
G
V
T
L
G
H
K
V
L
V
C
G
A
G
P
I
G
M
V
T
L
L
V
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
T
R
L
S
K
A
K
E
I
G
A
D
L
V
L
Q
I
-----
S
K
E
-----
S
--
P
Q
E
I
A
--
R
K
V
E
G
Q
L
G
C
KP
E
--
V
T
I
E
C
T
G
A
E
A
S
I
Q
A
G
I
Y
A
T
R
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
T
V
-
P
L
--
L
HA
A
I
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
V
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
---
T
F
K
K
G
L
G
L
K
I
M
L
----
25
PsiBlast_CBE
86.56
42%
-117
- C1 -
1PL7
1
DHSO_HUMAN
C:
[6-347]
-----
P
N
N
L
-
S
L
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
R
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
E
Y
G
R
I
G
N
F
I
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
E
K
V
G
S
S
V
K
H
L
K
P
G
D
R
V
A
I
E
P
G
A
--
P
R
E
N
D
E
F
C
K
M
G
R
Y
N
L
S
P
S
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
A
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
G
G
V
T
L
G
H
K
V
L
V
C
G
A
G
P
I
G
M
V
T
L
L
V
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
T
R
L
S
K
A
K
E
I
G
A
D
L
V
L
Q
I
-----
S
K
E
-----
S
--
P
Q
E
I
A
--
R
K
V
E
G
Q
L
G
C
KP
E
--
V
T
I
E
C
T
G
A
E
A
S
I
Q
A
G
I
Y
A
T
R
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
T
V
-
P
L
--
L
HA
A
I
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
V
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
---
T
F
K
K
G
L
G
L
K
I
M
L
----
4
PsiBlast_PDB
83.91
42%
-118
- C1 -
1PL6
3
DHSO_HUMAN
A:
[6-335]
-----
P
N
N
L
-
S
L
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
R
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
E
Y
G
R
I
G
N
F
I
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
E
K
V
G
S
S
V
K
H
L
K
P
G
D
R
V
A
I
E
P
G
A
--
P
R
E
N
D
E
F
C
K
M
G
R
Y
N
L
S
P
S
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
A
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
G
G
V
T
L
G
H
K
V
L
V
C
G
A
G
P
I
G
M
V
T
L
L
V
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
T
R
L
S
K
A
K
E
I
G
A
D
L
V
L
Q
I
-----
S
K
E
-----
S
--
P
Q
E
I
A
--
R
K
V
E
G
Q
L
G
C
KP
E
--
V
T
I
E
C
T
G
A
E
A
S
I
Q
A
G
I
Y
A
T
R
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
T
V
-
P
L
--
L
H
A
A
I
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
V
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
-------------------
5
PsiBlast_PDB
82.39
42%
-118
- C1 -
3QE3
4
DHSO_SHEEP
A:
[11-346]
------------
V
V
H
G
P
-
G
D
-
L
R
L
E
N
Y
P
I
P
E
P
G
P
-
N
-
E
V
L
L
K
M
H
S
V
G
I
C
G
S
D
V
-
H
Y
W
Q
H
G
R
I
G
D
F
V
V
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
V
K
V
G
S
L
V
R
H
L
Q
P
G
D
R
V
A
I
Q
P
G
A
--
P
R
Q
T
D
E
F
C
K
I
G
R
Y
N
L
S
P
T
I
F
F
-
C
A
-----------------------
T
P
P
----
D
D
G
N
L
C
R
F
Y
K
H
N
A
N
F
C
Y
K
--
L
P
D
N
V
T
F
E
E
G
A
L
I
-
E
-
P
L
S
V
G
I
H
A
C
-
R
R
-
A
G
V
T
L
G
N
K
V
L
V
C
G
A
G
P
I
G
L
V
N
L
L
A
A
K
A
M
G
A
A
Q
V
V
V
T
D
L
S
A
S
R
L
S
K
A
K
E
V
G
A
D
F
I
L
E
I
-----
S
N
E
-----
S
--
P
E
E
I
A
--
K
K
V
E
G
L
L
G
S
KP
E
--
V
T
I
E
C
T
G
V
E
T
S
I
Q
A
G
I
Y
A
T
H
S
G
-
G
T
L
V
L
V
G
L
G
S
E
M
T
---
S
V
-
P
L
--
V
H
A
A
T
---
R
E
V
D
I
K
G
-
V
F
----
R
--
Y
C
N
T
W
---
P
M
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
P
L
E
K
A
L
E
A
F
E
T
S
K
--
K
G
L
G
-
L
K
V
M
I
----
37
PsiBlast_CBE
77.90
36%
-136
- C1 -
3PII
5
ADH3_GEOSE
C:
[1-325]
--------
M
K
A
A
V
V
E
Q
F
-
K
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
-
G
-
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
-
H
----
A
A
H
G
D
W
P
V
K
P
KL
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
YS
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
-
E
H
Q
K
-
N
A
-----------------------
G
Y
S
----
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
--
I
P
D
N
L
S
F
E
E
A
A
P
I
-
F
-
C
A
G
V
T
T
Y
K
A
-
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
-----
L
K
E
-----
D
--
A
A
K
F
M
--
K
E
K
V
G
--
G
V
--
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
-
G
A
C
V
L
V
G
L
P
P
E
-
E
M
P
I
P
I
-
F
D
--
T
--
V
L
---
N
G
I
K
I
I
G
S
I
V
----
G
--
T
R
K
D
L
---
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
---
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
---------------
130
HHSearch
77.38
31%
-125
- C1 -
1E3I
4
ADH4_MOUSE
A:
[4-368]
---
G
K
V
I
K
C
K
A
A
I
A
W
K
T
G
S
P
-
L
C
I
E
E
I
E
V
S
P
P
K
A
-
C
-
E
V
R
I
Q
V
I
A
T
C
V
C
P
T
D
I
-
N
A
T
D
P
K
K
K
----
A
L
F
--
P
V
V
L
G
H
E
C
A
G
I
V
E
S
V
G
P
G
V
T
N
F
K
P
G
D
K
V
I
P
F
F
A
P
--
Q
C
K
R
C
K
L
C
L
S
P
L
T
N
L
C
G
K
L
R
N
F
K
Y
PTIDQELMEDRTSRFTCKG
R
S
I
Y
H
F
M
----
G
V
S
S
F
S
Q
Y
T
V
V
S
E
A
N
L
A
R
--
V
D
D
E
A
N
L
E
R
V
C
L
I
-
G
C
G
F
S
S
G
Y
G
A
A
I
N
T
-
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
C
V
G
L
S
A
I
I
G
C
K
I
A
G
A
S
R
I
I
A
I
D
I
N
G
E
K
F
P
K
A
K
A
L
G
A
T
D
C
L
N
P
-----
R
E
L
-----
D
KP
V
Q
D
V
I
--
T
E
L
T
A
-
G
G
V
--
D
--
Y
S
L
D
C
A
G
T
A
Q
T
L
K
A
A
V
D
C
T
V
L
G
W
G
S
C
T
V
V
G
A
K
V
D
-
E
M
T
I
P
T
-
V
D
--
V
--
I
----
L
G
R
S
I
N
G
-
T
F
FGGW
K
--
S
V
D
S
V
---
P
N
L
V
S
D
Y
K
N
K
K
F
D
L
D
L
L
V
T
H
A
L
P
F
E
S
I
N
D
A
I
D
L
M
K
E
G
K
-------------
12
PsiBlast_PDB
77.31
36%
-135
- C1 -
1RJW
4
ADH3_GEOSE
A:
[1-325]
--------
M
K
A
A
V
V
E
Q
F
-
K
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
-
G
-
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
-
H
----
A
A
H
G
D
W
P
V
K
P
KL
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
YS
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
-
E
H
Q
K
-
N
A
-----------------------
G
Y
S
----
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
--
I
P
D
N
L
S
F
E
E
A
A
P
I
-
F
-
C
A
G
V
T
T
Y
K
A
-
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
-----
L
K
E
-----
D
--
A
A
K
F
M
--
K
E
K
V
G
--
G
V
--
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
-
G
A
C
V
L
V
G
L
P
P
E
-
E
M
P
I
P
I
-
F
D
--
T
--
V
L
---
N
G
I
K
I
I
G
S
I
V
----
G
--
T
R
K
D
L
---
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
---
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
---------------
40
PsiBlast_CBE
77.30
31%
-124
- C1 -
4CPD
3
?
C:
[1-343]
--------
M
R
A
V
V
F
E
N
K
-
E
R
-
V
A
V
K
E
V
N
A
P
R
L
Q
H
-
P
L
D
A
L
V
R
V
H
L
A
G
I
C
G
S
D
L
-
H
L
Y
H
----
G
K
I
P
V
L
P
--
G
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
-
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
--
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
E
R
G
G
V
-
Y
G
-----------------------
Y
G
P
MFGN
L
Q
G
A
Q
A
E
I
L
R
V
P
F
S
N
V
N
L
RK
L
P
P
N
L
S
P
E
R
A
I
F
A
G
D
-
I
L
S
T
A
Y
G
G
L
-
I
Q
-
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
G
P
V
G
L
M
A
I
E
V
A
Q
V
L
G
A
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
I
P
-
I
N
A
-----
E
Q
E
-----
N
--
P
V
R
R
V
--
R
S
E
T
N
D
E
G
P
--
D
--
L
V
L
E
A
V
G
G
A
A
T
L
S
L
A
L
E
M
V
R
P
G
-
G
R
V
S
A
V
G
V
D
N
A
P
S
F
P
F
---
P
L
--
A
--
S
G
---
L
V
K
D
L
T
F
-
R
I
----
G
--
L
A
N
V
H
LYI
D
A
V
L
A
L
L
A
S
G
R
L
Q
P
E
R
I
V
S
H
Y
L
P
L
E
E
A
P
R
G
Y
E
--
L
F
D
R
K
E
A
-
L
K
V
L
L
----
34
PsiBlast_CBE
77.02
36%
-136
- C1 -
1RJW
5
ADH3_GEOSE
C:
[1-325]
--------
M
K
A
A
V
V
E
Q
F
-
K
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
-
G
-
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
-
H
----
A
A
H
G
D
W
P
V
K
P
KL
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
YS
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
-
E
H
Q
K
-
N
A
-----------------------
G
Y
S
----
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
--
I
P
D
N
L
S
F
E
E
A
A
P
I
-
F
-
C
A
G
V
T
T
Y
K
A
-
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
-----
L
K
E
-----
D
--
A
A
K
F
M
--
K
E
K
V
G
--
G
V
--
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
-
G
A
C
V
L
V
G
L
P
P
E
-
E
M
P
I
P
I
-
F
D
--
T
--
V
L
---
N
G
I
K
I
I
G
S
I
V
----
G
--
T
R
K
D
L
---
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
---
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
---------------
35
PsiBlast_CBE
76.98
36%
-135
- C1 -
1RJW
6
ADH3_GEOSE
B:
[1-325]
--------
M
K
A
A
V
V
E
Q
F
-
K
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
-
G
-
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
-
H
----
A
A
H
G
D
W
P
V
K
P
KL
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
YS
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
-
E
H
Q
K
-
N
A
-----------------------
G
Y
S
----
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
--
I
P
D
N
L
S
F
E
E
A
A
P
I
-
F
-
C
A
G
V
T
T
Y
K
A
-
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
-----
L
K
E
-----
D
--
A
A
K
F
M
--
K
E
K
V
G
--
G
V
--
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
-
G
A
C
V
L
V
G
L
P
P
E
-
E
M
P
I
P
I
-
F
D
--
T
--
V
L
---
N
G
I
K
I
I
G
S
I
V
----
G
--
T
R
K
D
L
---
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
---
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
---------------
13
PsiBlast_PDB
76.92
36%
-133
- C1 -
3PII
5
ADH3_GEOSE
A:
[1-325]
--------
M
K
A
A
V
V
E
Q
F
-
K
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
-
G
-
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
-
H
----
A
A
H
G
D
W
P
V
K
P
K
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
YS
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
-
E
H
Q
K
-
N
A
-----------------------
G
Y
S
----
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
--
I
P
D
N
L
S
F
E
E
A
A
P
I
-
F
-
C
A
G
V
T
T
Y
K
A
-
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
-----
L
K
E
-----
D
--
A
A
K
F
M
--
K
E
K
V
G
--
G
V
--
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
-
G
A
C
V
L
V
G
L
P
P
E
-
E
M
P
I
P
I
-
F
D
--
T
--
V
L
---
N
G
I
K
I
I
G
S
I
V
----
G
--
T
R
K
D
L
---
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
---
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
---------------
33
PsiBlast_CBE
76.90
36%
-135
- C1 -
1RJW
6
ADH3_GEOSE
D:
[1-325]
--------
M
K
A
A
V
V
E
Q
F
-
K
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
-
G
-
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
-
H
----
A
A
H
G
D
W
P
V
K
P
KL
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
YS
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
-
E
H
Q
K
-
N
A
-----------------------
G
Y
S
----
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
--
I
P
D
N
L
S
F
E
E
A
A
P
I
-
F
-
C
A
G
V
T
T
Y
K
A
-
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
-----
L
K
E
-----
D
--
A
A
K
F
M
--
K
E
K
V
G
--
G
V
--
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
-
G
A
C
V
L
V
G
L
P
P
E
-
E
M
P
I
P
I
-
F
D
--
T
--
V
L
---
N
G
I
K
I
I
G
S
I
V
----
G
--
T
R
K
D
L
---
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
---
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
---------------
143
HHSearch
76.53
33%
-118
- C1 -
2DQ4
3
TDH_THET8
A:
[1-342]
--------
M
R
A
L
A
K
L
A
P
E
E
G
-
L
T
L
V
D
R
P
V
P
E
P
G
P
-
G
-
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
-
H
I
W
K
W
D
A
W
A
R
G
R
I
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
--
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
-
L
------------------------
G
V
D
----
R
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
--
N
P
K
D
L
P
F
E
V
A
A
I
L
-
E
-
P
F
G
N
A
V
H
T
V
-
Y
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
L
V
N
P
-----
L
E
E
-----
D
--
L
L
E
V
V
--
R
R
V
T
-
G
S
G
V
--
E
--
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
-
G
E
A
R
I
L
G
I
P
S
D
P
-
I
R
F
D
L
A
G
E
--
L
--
V
M
---
R
G
I
T
A
F
G
-
I
A
----
G
RR
L
W
Q
T
W
---
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
P
L
S
R
Y
R
E
A
F
G
L
L
A
S
G
Q
--
A
-
V
K
V
I
L
D
P
K
-
27
PsiBlast_CBE
72.55
37%
-130
- C1 -
3M6I
3
LAD_NEUCR
B:
[37-359]
------------------------------
E
L
K
E
-
G
-
E
V
T
V
A
V
R
S
T
G
I
C
G
S
D
V
-
H
F
W
K
H
G
C
I
G
P
M
I
V
E
C
--
D
H
V
L
G
H
E
S
A
G
E
V
I
A
V
H
P
S
V
K
S
I
K
V
G
D
R
V
A
I
E
P
Q
V
--
I
C
N
A
C
E
P
C
L
T
G
R
Y
N
G
C
E
R
V
D
F
-
L
S
-----------------------
T
P
P
----
V
P
G
L
L
R
R
Y
V
N
H
P
A
V
W
C
H
K
--
I
-
G
N
M
S
Y
E
N
G
A
M
L
-
E
-
P
L
S
V
A
L
A
G
L
-
Q
R
-
A
G
V
R
L
G
D
P
V
L
I
C
G
A
G
P
I
G
L
I
T
M
L
C
A
K
A
A
G
A
C
P
L
V
I
T
D
I
D
E
G
R
L
K
F
A
K
E
I
C
P
E
V
V
T
H
K
-----
V
E
R
-----
L
--
S
A
E
E
S
AK
K
I
V
E
S
F
G
G
I
--
E
PA
V
A
L
E
C
T
G
V
E
S
S
I
A
A
A
I
W
A
V
K
F
G
-
G
K
V
F
V
I
G
V
-
G
K
N
E
I
--
Q
I
-
P
F
--
M
RA
S
V
---
R
E
V
D
L
Q
F
-
Q
Y
----
R
--
Y
C
N
T
W
---
P
R
A
I
R
L
V
E
N
G
L
V
D
L
T
R
L
V
T
H
R
F
P
L
E
D
A
L
K
A
F
E
T
A
S
D
P
K
T
G
A
-
I
K
V
Q
I
----
9
PsiBlast_PDB
69.09
33%
-115
- C1 -
2DQ4
3
TDH_THET8
A:
[19-342]
---------------------------
P
V
P
E
P
G
P
-
G
-
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
-
H
I
W
K
W
D
A
W
A
R
G
R
I
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
--
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
-
L
G
-----------------------
V
D
-----
R
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
--
N
P
K
D
L
P
F
E
V
A
A
I
L
-
E
-
P
F
G
N
A
V
H
T
V
-
Y
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
L
V
N
P
-----
L
E
E
-----
D
--
L
L
E
V
V
--
R
R
V
T
G
S
-
G
V
--
E
--
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
-
G
E
A
R
I
L
G
I
P
S
D
---
P
I
R
F
-
D
L
--
A
--
G
E
LVM
R
G
I
T
A
F
G
-
I
A
G
R--
R
--
L
W
Q
T
W
---
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
P
L
S
R
Y
R
E
A
F
--
G
L
L
A
S
G
Q
A
-
V
K
V
I
L
D
P
K
-
29
PsiBlast_CBE
68.50
33%
-114
- C1 -
2DQ4
3
TDH_THET8
B:
[19-342]
---------------------------
P
V
P
E
P
G
P
-
G
-
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
-
H
I
W
K
W
D
A
W
A
R
G
R
I
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
--
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
-
L
G
-----------------------
V
D
-----
R
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
--
N
P
K
D
L
P
F
E
V
A
A
I
L
-
E
-
P
F
G
N
A
V
H
T
V
-
Y
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
L
V
N
P
-----
L
E
E
-----
D
--
L
L
E
V
V
--
R
R
V
T
G
S
-
G
V
--
E
--
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
-
G
E
A
R
I
L
G
I
P
S
D
---
P
I
R
F
-
D
L
--
A
--
G
E
LVM
R
G
I
T
A
F
G
-
I
A
GR--
R
--
L
W
Q
T
W
---
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
P
L
S
R
Y
R
E
A
F
--
G
L
L
A
S
G
Q
A
-
V
K
V
I
L
D
P
K
-
28
PsiBlast_CBE
67.94
33%
-113
- C1 -
2EJV
4
TDH_THET8
B:
[19-342]
---------------------------
P
V
P
E
P
G
P
-
G
-
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
-
H
I
W
K
W
D
A
W
A
R
G
R
I
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
--
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
-
L
G
-----------------------
V
D
-----
R
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
--
N
P
K
D
L
P
F
E
V
A
A
I
L
-
E
-
P
F
G
N
A
V
H
T
V
-
Y
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
L
V
N
P
-----
L
E
E
-----
D
--
L
L
E
V
V
--
R
R
V
T
G
S
-
G
V
--
E
--
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
-
G
E
A
R
I
L
G
I
P
S
D
---
P
I
R
F
-
D
L
--
A
--
G
E
LVM
R
G
I
T
A
F
G
-
I
A
GR--
R
--
L
W
Q
T
W
---
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
P
L
S
R
Y
R
E
A
F
--
G
L
L
A
S
G
Q
A
-
V
K
V
I
L
D
P
K
-
10
PsiBlast_PDB
67.61
33%
-114
- C1 -
2EJV
4
TDH_THET8
A:
[19-342]
---------------------------
P
V
P
E
P
G
P
-
G
-
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
-
H
I
W
K
W
D
A
W
A
R
G
R
I
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
--
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
-
L
G
-----------------------
V
D
-----
R
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
--
N
P
K
D
L
P
F
E
V
A
A
I
L
-
E
-
P
F
G
N
A
V
H
T
V
-
Y
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
L
V
N
P
-----
L
E
E
-----
D
--
L
L
E
V
V
--
R
R
V
T
G
S
-
G
V
--
E
--
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
-
G
E
A
R
I
L
G
I
P
S
D
---
P
I
R
F
-
D
L
--
A
--
G
E
LVM
R
G
I
T
A
F
G
-
I
A
GR--
R
--
L
W
Q
T
W
---
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
P
L
S
R
Y
R
E
A
F
--
G
L
L
A
S
G
Q
A
-
V
K
V
I
L
D
P
K
-
55
PsiBlast_CBE
48.99
32%
-112
- C1 -
4UEJ
4
GATD_ECOLI
A:
[1-295]
--------
M
K
S
V
V
N
D
T
D
-
G
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
-
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
K
N
G
--
A
H
Y
Y
-----
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
--
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
-
I
G
-----------------------
S
R
R
-----
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
--
L
P
T
D
M
P
I
E
D
G
A
F
I
-
E
-
P
I
T
V
G
L
H
A
F
-
H
L
-
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
F
N
S
-----
S
E
M
-----
S
--
A
P
Q
M
Q
--
S
V
L
R
E
L
R
F
N
--
Q
--
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
-
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
-
T
F
G
K
I
--
L
R
---
K
E
L
T
V
I
G
-
S
W
M
---
N
--
Y
S
S
P
W
---
P
--------------------------------------------------
54
PsiBlast_CBE
48.57
32%
-113
- C1 -
4UEJ
4
GATD_ECOLI
B:
[1-295]
--------
M
K
S
V
V
N
D
T
D
-
G
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
-
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
K
N
G
--
A
H
Y
Y
-----
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
--
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
-
I
G
-----------------------
S
R
R
-----
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
--
L
P
T
D
M
P
I
E
D
G
A
F
I
-
E
-
P
I
T
V
G
L
H
A
F
-
H
L
-
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
F
N
S
-----
S
E
M
-----
S
--
A
P
Q
M
Q
--
S
V
L
R
E
L
R
F
N
--
Q
--
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
-
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
-
T
F
GK
I
--
L
R
---
K
E
L
T
V
I
G
-
S
W
M---
N
--
Y
S
S
P
W
---
P
--------------------------------------------------
53
PsiBlast_CBE
48.04
32%
-113
- C1 -
4UEK
4
GATD_ECOLI
A:
[1-295]
--------
M
K
S
V
V
N
D
T
D
-
G
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
-
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
K
N
G
--
A
H
Y
Y
-----
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
--
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
-
I
G
-----------------------
S
R
R
-----
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
--
L
P
T
D
M
P
I
E
D
G
A
F
I
-
E
-
P
I
T
V
G
L
H
A
F
-
H
L
-
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
F
N
S
-----
S
E
M
-----
S
--
A
P
Q
M
Q
--
S
V
L
R
E
L
R
F
N
--
Q
--
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
-
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
-
T
F
G
K
I
--
L
R
---
K
E
L
T
V
I
G
-
S
W
M
---
N
--
Y
S
S
P
W
---
P
--------------------------------------------------
52
PsiBlast_CBE
48.02
32%
-112
- C1 -
4UEK
4
GATD_ECOLI
B:
[1-295]
--------
M
K
S
V
V
N
D
T
D
-
G
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
-
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
K
N
G
--
A
H
Y
Y
-----
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
--
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
-
I
G
-----------------------
S
R
R
-----
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
--
L
P
T
D
M
P
I
E
D
G
A
F
I
-
E
-
P
I
T
V
G
L
H
A
F
-
H
L
-
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
F
N
S
-----
S
E
M
-----
S
--
A
P
Q
M
Q
--
S
V
L
R
E
L
R
F
N
--
Q
--
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
-
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
-
T
F
GK
I
--
L
R
---
K
E
L
T
V
I
G
-
S
W
M---
N
--
Y
S
S
P
W
---
P
--------------------------------------------------