@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06230: (2016-06-09 )
MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQLNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPNVTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNAILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIRDEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIMYYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTALLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMGVTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQLEENFRAYDHSGAKKDSGAEVIG
Atome Classification :
(20 SA)
.........10........20.-.......30........40---.------.------.------...--------------.----..50..--..---.....60......-...--70......--------..80........90.....------.------------------.------------------.------------------100------.---....----------....110.......120.......130.......140.......150.......160..---.....---.----.170--........180.......190.......200...-...-..210-.......220.......230.......240..--------....-.-250-.......260.......270.......280.......290.......300.......310.......320......-.330.......--340.......350.......360.--.....-.370.......380.......390.......400.......410-----.------.......420.......430.......440.......450.......460.......470.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKQG
N
Q
M
S
F
L
R
T
I
I
L
V
S
TFG
G
-
L
L
FGYDTGVLNGALPYMG----E------P------D------QL
N
--------------
L
----
N
A
F
-
T
E
--
G
L
---
V
T
S
S
L
L
-
F
G
A
A
L
G
-
A
V
F--GGRMSDFN--------GRR
K
N
I
L
F
L
A
V
I
F
F
I
S
TIG------C------------------T------------------F------------------A--------P---N
V
T
V
----------
M
I
I
S
R
F
V
L
G
I
AVGG
A
S
V
T
V
P
A
Y
L
A
EMS
P
V
E
SRG
R
M
VTQN
E
L
M
I
VS
G
Q
L
L
A
F
V
F
N
A
--
I
L
---GTTMG---D----N
S
H
---
V
W
R
F
M
L
V
I
A
S
L
P
A
L
F
L
F
F
G
M
I
RMPESP
R
W
L
-
V
SK-GR
K
-
E
D
A
L
R
-
V
L
K
K
I
R
D
E
K
R
A
A
A
E
L
Q
E
I
E
F
A
FKKE
D
Q
L
E
K
A
T
--------FKDL-
S
-
V
P
W
-
V
R
R
I
V
F
I
G
L
G
I
A
I
V
Q
Q
I
TGV
N
S
I
M
Y
Y
G
T
E
I
L
RNSGF
Q
T
E
A
A
L
I
G
N
I
A
N
G
V
I
S
V
L
A
T
F
V
G
I
W
L
L
G
RVGRR
P
M
L
M
TG
L
-
I
G
T
T
T
A
L
L
L
I
G
--
I
F
S
L
V
LEGSPAL
P
Y
V
V
L
S
L
T
V
T
F
L
--
A
F
QQG-AI
S
P
V
T
W
L
M
L
S
EI
F
P
L
R
L
RGLG
M
G
V
T
V
F
C
L
W
M
V
N
F
A
V
S
F
T
F
P
I
------
L
------
L
A
A
IGLS
T
T
F
F
I
F
V
G
L
G
I
C
S
V
L
F
V
K
R
FLPETKGL
S
L
E
Q
L
E
E
N
F
R
AYDHSGAKKDSGAEVIG
4
PsiBlast_PDB
84.88
34%
-131
- C3 -
4GC0
5
XYLE_ECOLI
A:
[5-475]
----
Y
N
S
-
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
FV
A
------
P
------
Q
------
N
L
S
--------------
E
----
S
A
A
-
N
S
L
L
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
------------------
A
------------------
W
------------------
P
ELGFTSIN
P
---
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
-
G
---
D
A
S
W
L
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
---
D
H
G
R
K
T
G
--------
G
R
L
L
-
M
-
F
G
---
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
-----
M
A
I
G
--
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
--
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
---------------------
3
PsiBlast_PDB
84.72
34%
-132
- C3 -
4GBZ
5
XYLE_ECOLI
A:
[5-475]
----
Y
N
S
-
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
FV
A
------
P
------
Q
------
N
L
S
--------------
E
----
S
A
A
-
N
S
L
L
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
------------------
A
------------------
W
------------------
P
ELGFTSIN
P
---
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
-
G
---
D
A
S
W
L
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
---
D
H
G
R
K
T
G
--------
G
R
L
L
-
M
-
F
G
---
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
-----
M
A
I
G
--
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
--
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
---------------------
2
PsiBlast_PDB
84.56
34%
-132
- C3 -
4GBY
5
XYLE_ECOLI
A:
[5-475]
----
Y
N
S
-
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
FV
A
------
P
------
Q
------
N
L
S
--------------
E
----
S
A
A
-
N
S
L
L
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
------------------
A
------------------
W
------------------
P
ELGFTSIN
P
---
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
-
G
---
D
A
S
W
L
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
---
D
H
G
R
K
T
G
--------
G
R
L
L
-
M
-
F
G
---
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
-----
M
A
I
G
--
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
--
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
---------------------
39
Fugue
83.44
33%
-133
- C3 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
-----
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
----
T
------
V
FVAPQN
L
------
S
E
S
--------------
A
----
A
N
S
-
L
L
--
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
A
WPELGFTSINPDNTVPV
Y
------------------
L
------------------
A
--------
G
---
Y
V
P
E
----------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
G
D
---
A
----
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
L
--------
L
M
F
G
--------
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
M
A
I
G
M
F
S
L
G
--
T
A
F
Y
----
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
--
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-----------------
17
PsiBlast_CBE
80.86
34%
-145
- C3 -
4JA3
2
XYLE_ECOLI
B:
[7-471]
------
S
-
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
FV
A
------
P
------
Q
------
N
L
S
--------------
E
----
S
A
A
-
N
S
L
L
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
------------------
A
------------------
W
------------------
P
ELGF
T
S
I
N
P
---
D
N
T
V
P
VYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
-
G
---
D
A
S
W
L
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
---
D
H
G
R
------------------------
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
-----
M
A
I
G
--
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
--
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
---
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
KNS------------
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
-------------------------
15
PsiBlast_CBE
80.58
34%
-159
- C3 -
4JA4
1
XYLE_ECOLI
C:
[9-475]
---------
Y
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
TVFV
A
------
P
------
Q
------
N
L
S
--------------
E
----
S
A
A
-
N
S
LL
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
------------------
A
------------------
W
------------------
P
ELGFTSIN
P
-----
T
V
PVYLAGYVPE
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
-
G
---
D
ASWL
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
-----
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
---
D
H
G
-----------------
M
-
F
G
---
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
-----
M
A
I
G
--
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
VA
A
F
A
M
--
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
MDKN---------------
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
---------------------
5
PsiBlast_PDB
79.80
34%
-157
- C3 -
4JA4
1
XYLE_ECOLI
A:
[9-475]
---------
Y
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
FV
A
------
P
------
Q
------
N
L
S
--------------
E
----
S
A
A
-
N
S
L
L
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
------------------
A
------------------
W
------------------
P
ELGF
T
S
I
N
P
---
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
-
G
---
D
A
S
W
L
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
-----
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
---
D
H
G
-----------------
M
-
F
G
---
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-----------
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
-----
M
A
I
G
--
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
--
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
DKNSW------------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
---------------------
16
PsiBlast_CBE
79.42
34%
-156
- C3 -
4JA4
1
XYLE_ECOLI
B:
[9-475]
---------
Y
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
FV
A
------
P
------
Q
------
N
L
S
--------------
E
----
S
A
A
-
N
S
L
L
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
------------------
A
------------------
W
------------------
P
ELGF
T
S
I
N
P
---
D
N
--PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
-
G
---
D
A
S
W
L
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
-----
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
---
D
H
G
-----------------
M
-
F
G
---
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
-----
M
A
I
G
--
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
--
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
DKNSW------------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
---------------------
8
PsiBlast_PDB
78.73
28%
-128
- C3 -
4ZW9
4
GTR3_HUMAN
A:
[36-492]
--------------
I
T
V
A
T
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
----
E
F
I
T
K
T
L
T
------
D
------
K
G
N
--------------
A
----
P
P
--
S
E
--
V
L
---
L
T
S
L
W
S
-
L
S
V
A
I
F
-
S
V
---
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
---
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
------------------
K
------------------
V
------------------
A
--------
K
---
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
EF
I
L
---
G
S
------------
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
--------
V
L
E
L
F
R
-
V
S
S
-
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
-
G
G
M
A
F
C
S
T
L
M
T
--
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
--
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------
6
PsiBlast_PDB
78.10
29%
-148
- C3 -
4PYP
1
GTR1_HUMAN
A:
[19-455]
-----------------
A
V
L
G
S
-
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
----
E
F
-----
Y
------
T
------
Q
T
W
--------------
V
----
H
R
Y
-
G
E
--
S
I
---
L
P
T
T
L
T
-
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
------
M
------------------
G
------------------
F
------------------
S
--------
K
LGK
S
F
E
M
----------
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
----
L
---
D
S
I
M
G
--------
N
K
D
---
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
N
E
E
-
N
R
A
K
S
-
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
--------
I
L
E
L
F
R
-
S
P
A
-
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
Q
Q
--
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
-
A
G
M
A
G
C
A
I
L
M
T
--
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
--
A
F
F
E
V
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
------
E
Q
L
C
G
-
P
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
------------------------------
40
Fugue
77.57
34%
-164
- C3 -
4QIQ
1
XYLE_ECOLI
A:
[7-470]
--------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
----
T
V
FVA--
P
------
Q
------
N
L
S
--------------
E
----
S
A
A
-
N
S
L
L
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
------------------
A
WPELGFTSINPDNTVPVY
L
------------------
A
--------
G
---
Y
V
P
E
----------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
A
R
S
G
D
A
S
W
---
L
----
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
T
---------------------
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
R
L
----------------------
L
M
F
-
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
M
A
I
G
M
F
S
L
G
--
T
-
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
--
A
M
----
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
DKN
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
-------------------------
10
PsiBlast_PDB
77.51
28%
-134
- C3 -
4ZWC
3
GTR3_HUMAN
A:
[36-492]
--------------
I
T
V
A
T
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
----
E
F
I
T
K
T
L
T
------
D
------
K
G
N
--------------
A
----
P
P
--
S
E
--
V
L
---
L
T
S
L
W
S
-
L
S
V
A
I
F
-
S
V
---
G
G
M
I
G
S
F
S
VGLFVNRF
G
R
R
N
S
M
L
---
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
------------------
K
------------------
V
------------------
A
--------
K
---
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
EF
I
L
---
G
S
------------
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
--------
V
L
E
L
F
R
-
V
S
S
-
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
-
G
G
M
A
F
C
S
T
L
M
T
--
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
--
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------
9
PsiBlast_PDB
77.50
28%
-129
- C3 -
4ZWB
1
GTR3_HUMAN
A:
[36-492]
--------------
I
T
V
A
T
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
----
E
F
I
T
K
T
L
T
------
D
------
K
G
N
--------------
A
----
P
P
--
S
E
--
V
L
---
L
T
S
L
W
S
-
L
S
V
A
I
F
-
S
V
---
G
G
M
I
G
S
F
S
VGLFVNRF
G
R
R
N
S
M
L
---
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
------------------
K
------------------
V
------------------
A
--------
K
---
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
EF
I
L
---
G
S
------------
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
--------
V
L
E
L
F
R
-
V
S
S
-
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
-
G
G
M
A
F
C
S
T
L
M
T
--
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
--
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------
18
HHSearch
77.29
29%
-149
- C3 -
4PYP
1
GTR1_HUMAN
A:
[17-455]
---------------
G
G
A
V
L
G
S
-
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
----
E
------
F
------
Y
T
Q
T
W
V
H
R
Y
G
E
S
I
L
P
T
--------
T
----
L
T
T
-
L
W
--
S
L
---
S
V
A
I
F
S
-
V
G
G
M
I
G
-
S
F
S
--
V
G
L
F
V
N
R
F
--------
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
------
M
------------------
G
------------------
F
------------------
S
KLG-----
K
---
S
F
E
M
----------
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
--
D
S
---
I
M
------
G
----
N
K
D
---
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
-
L
I
N
R
N
E
E
-
N
R
A
K
S
-
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
--------
I
L
E
L
-
F
R
S
P
A
-
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
--
Q
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
-
A
G
M
A
G
C
A
I
L
M
T
--
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
--
A
F
F
E
V
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
------
E
Q
L
C
G
P
-
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
------------------------------
22
HHSearch
77.13
34%
-133
- C3 -
4GC0
4
XYLE_ECOLI
A:
[10-429]
----------
I
F
S
I
T
L
V
A
T
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
----
T
------
V
------
F
VAPQNL
S
E
S
--------------
A
----
A
N
S
-
L
L
--
G
F
---
C
V
A
S
A
L
-
I
G
C
I
I
G
-
G
A
L
--
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
------
S
------------------
A
------------------
W
PELGFTSINPDNTVPVYL
A
--------
G
---
Y
V
P
E
----------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
G
D
A
S
W
L
----
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
----
K
H
S
L
D
H
G
R
K
T
--------
G
G
R
L
-
L
--
M
F
-
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
-
L
G
M
A
I
G
M
F
S
L
G
--
T
A
F
Y
----
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
--
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
-------------------------------------------------------------------
7
PsiBlast_PDB
75.52
28%
-132
- C3 -
5C65
8
GTR3_HUMAN
A:
[14-469]
--------------
I
T
V
A
T
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
----
E
------
F
------
I
------
Q
K
T
--------------
L
T
D
KG
N
A
P
P
S
E
--
V
L
---
L
T
S
L
W
S
-
L
S
V
A
I
F
-
S
V
---
G
G
M
I
G
S
F
S
VGLFVNRF
G
R
R
N
S
M
L
---
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
------------------
K
------------------
V
------------------
A
--------
K
---
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
EF
I
L
---
G
S
------------
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
--------
V
L
E
L
F
R
-
V
S
S
-
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
-
G
G
M
A
F
C
S
T
L
M
T
--
V
S
L
L
L
K
D
----
M
S
F
V
C
I
G
A
I
L
V
F
V
--
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
--------------
1
PsiBlast_PDB
74.83
36%
-141
- C3 -
4LDS
-
?
A:
[22-427]
----------------------------
D
N
G
V
I
S
G
A
L
L
F
I
H
----
K
--------------------
D
I
P
--------------
L
----
N
S
T
-
T
E
--
G
I
---
V
V
S
S
M
L
-
I
G
A
I
V
G
-
A
G
S
--
S
G
P
L
A
D
K
L
--------
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
L
I
------
L
------------------
A
------------------
A
------------------
S
--------
T
---
N
L
A
L
----------
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
--
A
F
---
A
D
I
E
G
---------------
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
-
L
E
N
-
R
N
E
-
E
A
A
R
Q
-
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
----
K
E
I
N
A
I
S
E
S
T
--------
W
T
V
I
-
K
-
S
P
W
-
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
-
I
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
--
G
I
S
W
G
----
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
------
L
------
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
----------------------------
21
HHSearch
74.24
36%
-138
- C3 -
4LDS
-
?
A:
[10-409]
---------------
I
L
G
A
L
G
G
-
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
H
----
K
--------------------
D
I
P
--------------
L
----
N
S
T
-
T
E
--
G
I
---
V
V
S
S
M
L
-
I
G
A
I
V
G
-
A
G
S
--
S
G
P
L
A
D
K
L
--------
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
L
I
------
L
------------------
A
------------------
A
------------------
S
--------
T
---
N
L
A
L
----------
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
--
A
F
---
A
D
I
------------
E
---
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
-
L
E
N
-
R
N
E
-
E
A
A
R
Q
-
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
----
K
E
I
N
A
I
S
E
S
T
--------
W
T
V
I
-
K
-
S
P
W
-
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
-
I
G
M
I
A
S
L
L
I
M
A
--
I
L
I
W
T
I
G
I
A
S
S
-
A
W
I
I
I
V
-
C
L
S
L
F
--
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
------
L
------
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
----------------------------------------------
23
HHSearch
72.27
27%
-130
- C3 -
4ZW9
4
GTR3_HUMAN
A:
[36-452]
--------------
I
T
V
A
T
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
----
E
--------------------
F
I
T
K
T
L
T
D
K
GNAPPS
E
V
L
----
L
T
S
-
L
W
--
S
L
---
S
V
A
I
F
S
-
V
G
G
M
I
G
-
S
F
S
--
V
G
L
F
V
N
R
F
--------
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
------
M
------------------
G
------------------
L
CKV---------------
A
--------
K
---
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
--
E
F
---
I
L
G
----------
S
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
-
L
I
N
-
R
K
E
E
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
--------
V
L
E
L
-
F
R
V
S
S
-
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--
G
V
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
-
G
G
M
A
F
C
S
T
L
M
T
--
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
--
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
A
Y
------------------------------------------------------
11
PsiBlast_PDB
72.04
26%
-148
- C3 -
4YB9
-
GTR5_BOVIN
D:
[19-462]
------------
L
A
T
L
I
A
A
F
G
S
S
F
Q
Y
G
Y
N
V
A
A
I
N
S
P
S
E
F
M
K
----
D
FYAYTY
Y
------
D
------
R
V
G
EY------------
M
----
N
E
F
-
Y
L
--
T
L
LWS
V
T
V
S
M
F
P
F
G
G
F
L
G
-
S
L
M
--
V
G
P
L
V
N
N
L
--------
G
R
K
G
T
L
L
F
N
N
I
F
S
I
V
P
A
L
L
------
M
------------------
G
------------------
F
SEL---------------
A
--------
K
---
S
F
E
M
----------
I
I
V
A
R
V
L
V
G
I
C
A
G
L
S
S
N
V
V
P
M
Y
L
G
E
L
A
P
K
N
W
R
G
A
L
G
V
V
P
Q
L
F
I
T
I
G
I
L
V
A
Q
I
F
G
L
--------
R
S
L
L
---
A
----
N
E
E
---
G
W
P
I
L
L
G
L
T
G
I
P
A
V
L
Q
L
L
F
L
P
F
F
P
E
S
P
R
Y
L
-
L
I
Q
-
K
K
D
-
E
A
A
A
K
S
A
L
R
R
L
-------
A
E
I
E
E
I
----
L
E
E
D
R
A
E
K
A
V
GFISVLKL
F
K
M
R
-
S
-
L
R
W
Q
V
I
S
I
I
V
L
M
A
G
----
Q
Q
L
S
G
V
N
A
I
Y
Y
Y
A
D
Q
I
Y
L
S
A
G
V
N
E
D
D
V
Q
Y
V
T
A
G
T
G
A
V
N
V
L
I
T
V
C
A
I
F
V
V
E
L
M
G
R
R
F
L
L
L
L
G
F
S
V
C
F
T
A
C
C
V
L
T
G
--
A
L
A
L
-
Q
D
V
I
S
W
M
P
Y
V
S
I
A
C
V
I
S
Y
V
--
I
G
H
A
L
-
G
P
S
P
I
P
A
L
L
V
T
E
I
F
L
Q
S
S
R
P
A
A
Y
M
V
A
G
T
V
H
W
L
S
N
F
T
V
G
L
V
F
P
F
------
I
------
Q
V
G
L
G
-
A
Y
S
F
V
I
F
A
V
I
C
L
L
T
T
V
Y
I
F
L
I
I
P
E
-------------------------------