@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06370: (2016-06-10 )
MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESVKDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMGISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSGIITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGLVPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQAGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTGILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMPLTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK
Atome Classification :
(20 SA)
---.........10........20........--30...-.....40........50........60..----......70..----..-.-.-..80..-......90...-----.....-100-.-....------..110.......120...----..-.---.130-------.......----.140.......150......-.160----..---....----.-.170..-....-------------.180...-...-..190..--..-----.-----------..--200--...-----------....-.210.......220----.......230.......-240--..-------...----...250...--.----------...260.--......270.....-.--.280...-....290.......---300.......310----.-.-......320----..-----.....330....----...----340.---.......350......---..360......--.370---...-..---...380--..--.......390.....-..400--...--...-...410---------......---.-420..--.-----....430...-----......440------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MK
T
F
F
Q
F
D
E
L
G
T
S
Y
R
N
E
I
I
G
G
L
T
T
F
L
S
M
A
--
Y
I
L
FV-
N
P
I
T
L
A
L
E
S
V
K
D
F
P
E
A
LRIDQGA
V
F
T
A
T
A
----
L
A
S
A
A
G
C
I
L
M
----
G
L
-
I
-
A
-RY
P
I
A
I-APGM
G
L
N
A
F
F
A
-----
F
S
V
V
L-GMG-
I
-
S
W
Q
A
------
A
L
S
G
V
F
I
S
G
L
I
F
V
A
L
SL
T
----
G
F
-
R
---
E
K
I
--------
I
N
AIPP
E
----
L
K
L
A
VGAG
I
G
L
F
I
T
F
VGLQG-S
G
I
-----
I
T---ANP
S
----
T
-
L
V
T
IGN-IHSG-------------
P
V
-
L
L
T
I
-
F
G
V
-
I
V
T
V
I
L
M
--
V
L
-----R-----------VN--
A
G
---
V
F
I
-----------
G
M
L
L
-
T
A
V
A
G
M
I
FGLVPV
P
----
T
Q
I
I
GSVPSL
A
P
T
F
G
Q
A
-WI---HL-------
P
D
I
----
F
S
V
Q
M
L
I
V
I
--
L
----------
T
F
L
F
V
G
F
--FDTA
G
T
L
V
A
V
A
T
QA-G--LMKENKL-PRA
G
R
A
LLADSS
S
I
---
V
I
G
A
V
LGTSTT
T
-----
S
-
Y
-VESSSGVAA----GA-----RS
G
F
A
A
I
V
T
G
I
L
----
F
L
L
----
A
-
T
F
---
F
S
P
L
L
S
V
V
-TSNVT
A
P
---
A
L
I
I
V
G
A
L
M
VA--P
L
G
----
K
IA-
W
D
---
K
F
E
V
----
A
V
--
P
A
F
L
T
M
I
M
M
P
L
T
Y
S
I
-
A
T
G
----
I
A
I
--
G
F
I
-
F
Y
P
I
T
M
---------
V
CKGKA---K-E
V
H
P
I
--
M
-----
Y
G
L
F
V
--
V
F
I
-----
L
Y
F
I
FLK--------------
28
Fugue
72.80
18%
-139
* C4 *
5DBJ
2
?
D:
[5-441]
------------
S
D
H
D
Y
D
V
V
I
I
G
G
G
P
A
G
S
T
M
A
--
S
Y
L
A
K
-
A
G
V
K
C
A
V
F
E
-
K
E
L
F
E
R
E
H
V
G
E
S
L
V
P
A
T
T
P
----
V
L
L
E
I
G
--
V
M
----
E
K
-
I
-
E
-
K
A
N
F
P
K
-
K
F
G
A
A
W
T
S
A
D
S
------
G
P
E
D
-
K
M
G
-
F
-
Q
---------
G
L
D
H
D
F
R
S
A
E
I
L
-----------
F
-
N
---
E
R
K
--------
Q
E
G
V
D
R
D
----
F
T
F
H
V
D
R
G
K
F
D
R
I
L
L
E
H
A
G
S
-
L
G
A
-----
K
V
---
F
Q
G
V
----
E
-
I
A
D
V
E
F
-
L
S
P
G
-------------
N
V
-
I
V
N
A
K
L
G
K
-
R
S
V
E
I
K
A
--
K
M
-----
V
-----------
V
D
--
A
S
GRN
V
L
L
-----------
G
R
R
L
G
L
R
E
K
D
P
V
F
N
Q
F
A
I
H
----
S
W
F
D
N
F
D
R
K
S
A
T
Q
S
P
D
K
---------------
V
D
Y
----
I
F
I
H
F
L
P
M
T
--
N
----------
T
W
V
W
Q
I
P
--
I
T
E
T
I
T
S
V
G
V
V
T
Q
K
-
Q
--
N
Y
T
N
S
D
L
-
T
Y
E
E
F
F
W
E
A
V
K
T
R
E
---
N
L
H
D
A
L
K
A
S
E
Q
V
-----
R
-
P
-
F
K
K
E
A
D
Y
S
Y
----
G
M
-----
K
E
-----
V
C
G
D
S
----
F
V
L
IGDA
A
-
R
F
---
V
D
P
I
F
S
S
G
-
V
S
V
A
L
N
S
---
A
R
I
A
S
G
D
I
I
E
A
--
V
K
N
NDFS
K
S
S
-
F
T
---
H
Y
E
G
MIRN
G
I
--
K
N
W
Y
E
F
I
T
L
Y
Y
R
L
N
I
-
L
F
T
----
A
F
V
QD
P
R
Y
-
R
L
D
I
L
Q
---------
L
L
Q
G
D
V
---
Y
L
E
V
L
D
K
--
M
-----
R
E
I
I
A
--
A
V
E
SDPEH
L
W
H
K
Y
L
G
--------------
34
Fugue
66.35
17%
-142
- C6 -
4QLA
1
HYEP_BOMMO
A:
[19-442]
-LD
L
E
E
W
W
G
P
P
E
L
K
Q
K
Q
D
T
S
I
K
P
F
E
I
T
F
S
------
E
T
M
V
-
K
E
L
K
E
R
I
K
K
R
R
P
F
A
P
P
L
---
E
G
V
G
F
K
Y
G
F
----
N
S
K
Q
L
D
S
W
L
K
----
Y
W
-
A
-
E
-
E
Y
P
F
A
E
-
R
Q
K
F
L
N
Q
Y
P
H
F
-----
K
T
N
I
Q
-
G
L
N
-
I
-
H
F
M
R
------
I
T
P
K
V
P
K
G
V
E
I
V
P
L
L
L
L
H
----
G
W
-
P
GSV
R
E
F
--------
Y
E
A
I
P
H
L
----
T
A
V
S
K
D
R
N
F
A
L
E
I
I
A
P
S
L
P
G
-
Y
G
F
-----
S
D
---
A
A
V
R
----
P
------
G
-
L
A
A
A
-------------
E
V
-
A
V
I
F
-
K
N
L
-
M
A
R
L
G
Y
K
--
Q
Y
-----
Y
-----------
V
Q
--
G
G
---
D
W
G
-----------
A
L
I
G
-
S
A
M
A
T
F
F
------
P
----
K
E
I
I
G
F
H
S
N
M
A
L
T
L
S
P
A
-
A
T
---
F
L
-------
E
F
V
----
G
A
L
F
P
S
L
I
V
--
E
----------
P
E
L
A
N
R
L
--
Y
P
L
S
E
K
Y
S
T
L
L
E
E
L
-
G
--
Y
M
H
I
Q
A
T
K
P
D
T
V
G
I
G
L
T
D
S
P
A
G
---
L
L
A
Y
I
L
E
K
F
S
T
W
-----
T
-
N
-
P
D
L
R
S
K
E
D
G
----
G
L
-----
S
Y
R
W
T
-------------
K
----
D
-
Q
L
---
I
D
N
L
M
L
Y
W
-
S
T
K
S
I
V
T
---
S
M
R
L
Y
A
E
S
F
S
S
--
R
H
F
----
D
L
K
-
L
D
---
E
I
Q
V
----
Q
V
--
P
T
W
V
L
Q
A
K
H
E
L
A
Y
Q
P
-
P
C
I
----
L
K
M
--
K
Y
P
K
L
V
N
A
S
V
---------
I
E
D
G
---------------------
G
H
F
L
--
A
F
E
-----
L
P
E
I
F
A
K
D
V
L
K
A
I
G
E
F
R
K
L
K
N
27
Fugue
66.25
18%
-164
- C7 -
3QE7
2
URAA_ECOLI
A:
[4-410]
----------
R
A
I
G
V
S
E
R
P
P
L
L
Q
T
I
P
L
S
L
Q
H
L
--
F
A
M
F
G
-
A
T
V
L
V
P
V
--------
L
F
H
I
N
P
A
T
V
L
L
F
N
G
----
I
G
T
L
L
Y
L
F
I
C
K---
G
K
-
I
-
P
-
A
Y
--------
L
G
S
S
F
A
F
I
-----
S
P
V
L
L
-
L
L
P
-
L
-
G
Y
E
V
------
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
----
V
K
-
K
A
GT
G
W
L
--------
D
V
L
F
P
P
A
----
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
-
A
G
L
-----
L
P
---
A
E
G
Q
----
T
-
P
----------------------------
D
S
-
K
T
I
-
I
I
S
I
T
T
L
--
A
V
-----
T
-----------
V
L
--
G
S
---
V
L
F
-----------
R
G
F
L
-
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
----
L
S
F
A
M
G
I
V
D
T
T
P
I
I
N
A
H
-
W
F
---
A
L
-------
P
T
L
Y
T
P
R
F
E
W
F
A
I
L
T
I
--
L
----------
P
A
A
L
V
V
I
--
A
E
H
V
G
H
L
V
V
T
A
N
I
V
-
K
KD
L
L
R
D
----
P
G
L
H
R
S
M
F
A
N
G
L
S
T
---
V
I
S
G
F
F
G
S
T
P
N
T
-----
T
-
Y
-
G
E
N
I
G
V
M
A
I
----
T
R
-----
V
Y
S
T
W
V
I
G
G
A
A
I
----
F
A
I
----
L
-
L
S
---
C
V
G
K
L
A
A
A
-
I
Q
M
I
P
L
P
---
V
M
G
G
V
S
L
L
L
Y
G
--
V
I
G
----
A
S
G
-
I
R
---
V
L
I
E
----
S
K
--
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
-
L
I
I
----
G
V
S
--
G
------
A
K
V
---------
N
I
G
A
A
E
---
L
-
K
G
M
A
L
--
A
-----
T
I
V
G
I
--
G
L
S
-----
L
I
F
K
L
I
S
--------------
31
Fugue
65.43
23%
-156
- C4 -
4UY5
2
EGTD_MYCS2
A:
[2-327]
T
L
S
L
A
N
Y
L
A
A
D
S
A
A
E
A
L
R
R
D
V
R
A
G
L
T
---------------------
A
A
P
K
S
L
P
------------
P
K
W
----
F
Y
D
A
V
G
S
D
L
F
----
D
Q
-
I
-
T
-
R
L
P
-------------------------------------------------------
E
Y
Y
P
T
----
R
T
-
E
---
A
Q
I
--------
L
R
T
R
S
A
E
----
I
I
A
A
A
G
A
D
-----
T
L
V
E
L
-
G
-
S
G
-------
T
---
S
E
K
T
----
R
M
L
L
D
--
A
M
R
D
A
E
-------------
L
L
R
R
F
I
P
-
F
D
V
-
D
A
G
V
L
R
S
--
A
G
-----
A
-----------
A
I
--
G
A
---
E
Y
P
-----------
G
I
E
I
-
D
A
V
C
G
-------------------------
D
F
E
E
-------
H
L
-------
G
K
I
----
P
H
V
G
R
R
L
V
V
--
F
----------------------
L
G
S
T
I
G
N
L
T
P
A
-
P
----
R
A
E
F
L
-
S
T
L
A
D
T
L
-
Q
P
G
D
S
L
---
L
L
G
T
D
L
V
K
D
--
T
-----
G
-
R
-
L
V
R
A
Y
D
D
A
A
----
G
-----------------------
V
T
----
A
-
A
F
---
N
R
N
V
L
A
V
V
-
N
R
E
L
S
A
D
FDL
D
A
F
E
H
V
A
K
W
N
S
--
D
E
E
----
R
I
E
M
W
-----
L
R
A
----
R
T
--
A
Q
H
V
R
V
A
A
L
D
L
E
V
D
F
-
A
A
G
E
E
M
L
T
E
V
--
S
C
K
-
F
R
P
E
N
V
---------
V
A
E
L
A
E
A
GL
R
-
Q
T
H
W
W
--
T
D
PAGD
F
G
L
S
L
--
A
V
R
-----
L
E
H
H
H
H
---------------
17
HHSearch
60.02
15%
-143
- C7 -
5DA0
2
?
A:
[14-394]
--------
Q
R
E
W
F
-
A
N
P
R
K
D
V
L
A
G
I
V
V
A
L
A
L
I
---------
P
E
A
I
A
F
S
I
I
A
G
----------
V
D
P
Q
V
G
L
----
Y
A
S
F
I
I
A
L
I
T
----
A
F
-
L
-
G
-
G
R
P
G
M
I
S
A
A
T
-
G
A
M
A
L
L
M
-----
T
G
L
V
K
---
D
-
H
-
G
I
Q
Y
------
L
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
L
-----
A
R
Y
--------
L
K
F
V
P
R
S
----
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
V
G
A
-----
N
W
---
Q
---------------------------------
M
Y
-
A
M
V
A
-
A
G
L
-
A
I
I
Y
L
L
P
L
V
F
K
-----
A
-----------
M
P
--
S
A
---
L
-
V
-----------
A
I
V
V
-
L
T
V
V
A
V
V
T
G
A
D
V
K
T
----
V
G
D
M
G
T
L
P
T
A
L
P
H
F
Q
F
P
-
Q
V
---
P
L
-------
T
F
E
----
T
L
A
I
I
F
P
V
A
--
L
----------
T
L
S
L
V
G
L
--
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
-
D
-------
T
T
-
S
D
K
N
V
E
S
R
G
Q
G
V
A
N
---
I
V
T
G
F
F
G
G
M
A
G
C
-----
A
M
I
-
G
Q
S
M
I
N
V
T
S
----
G
G
-----
R
G
R
L
S
T
F
V
A
G
A
F
----
L
M
V
----
L
I
L
A
---
L
Q
P
L
L
V
Q
I
-
P
M
A
A
L
V
A
---
V
M
M
V
V
A
I
S
T
F
D
WG
S
L
R
----------F--
P
K
G
E
----
T
V
--
V
M
L
A
T
V
A
V
T
V
F
T
H
D
L
-
S
L
G
----
V
L
I
--
G
V
V
-
L
S
A
L
F
F
---------
A
R
K
V
S
Q
---
L
--------------------------------------------------
36
Fugue
59.82
19%
-148
- C3 -
4NNB
2
?
A:
[4-527]
---
T
S
L
Y
I
T
A
---------
A
P
I
G
A
V
P
K
F
L
D
P
F
--
E
A
T
F
I
-
P
--
S
F
L
L
E
G
F
F
D
A
D
R
C
A
S
I
A
A
D
L
K
T
D
G
W
E
----
V
V
P
A
G
G
R
L
L
Q
V
GHA
Q
P
-
I
-
A
-
H
F
P
K
P
W
-
L
A
A
--
L
S
N
K
L
A
-----
R
R
I
V
L
-
Q
L
T
-
T
Y
G
W
I
V
------
S
E
Q
G
----
D
L
L
W
E
H
E
R
Q
H
----
H
Y
L
P
---
P
A
L
--------
I
E
A
I
E
K
E
S
P
A
L
L
K
N
M
E
E
A
G
W
I
A
C
A
A
G
Y
W
Q
A
G
-
K
A
R
SPYLP
I
T
---
P
E
A
I
----
T
-
E
E
T
I
R
S
-
M
R
A
G
AA
V
V
H
L
H
T
R
D
LSD
R
R
-
R
I
E
I
-
P
G
L
G
V
V
T
V
G
S
Q
--
R
N
-----
Q
-----------
I
V
--
L
D
---
D
Y
D
-----------
A
I
V
P
-
M
V
K
K
R
E
P
A
A
I
L
N
L
S
----
T
S
V
R
G
D
R
H
G
A
R
S
K
L
R
R
A
-
H
L
---
K
F
YDDVGSA
P
E
V
----
A
S
L
S
P
A
A
V
V
--
F
QG
G
G
G
Y
D
NA
P
D
F
L
D
A
Q
F
D
H
F
E
R
V
G
T
R
P
E
V
E
V
F
N
-
H
--
A
I
V
D
N
A
T
-
S
L
Y
R
D
R
L
L
R
T
G
K
P
V
---
L
F
M
L
V
A
G
V
D
Q
Y
R
R
DPIT
G
-
E
-
V
E
D
D
S
L
I
A
R
----
V
V
-----
R
E
E
I
S
S
L
L
A
D
-------------------------
E
S
A
-
D
S
H
R
R
A
V
---
E
L
A
I
G
Q
L
R
P
V
V
--
E
R
L
----
R
A
S
-
F
P
---
V
S
K
I
----
S
I
L
L
P
G
P
M
Q
N
L
L
V
D
V
A
L
G
L
G
L
D
G
----
I
R
V
--
G
L
E
-
D
G
L
T
V
N
D
ARVPGG
V
R
K
A
R
G
T
W
---
E
-
Q
V
S
L
V
--
R
-----
E
E
L
L
G
R
G
A
T
I
-----
L
T
A
A
Q
V
R
D
M
F
GLGI-------
18
HHSearch
59.39
19%
-154
* C7 *
3QE7
2
URAA_ECOLI
A:
[4-341]
-----
R
A
I
G
V
S
E
R
P
P
-
L
L
Q
T
I
P
L
S
L
Q
H
L
F
A
M
F
--
G
A
T
V
L
-
V
P
V
L
F
H
----------------
I
N
P
A
T
V
L
----
L
F
N
G
I
G
T
L
L
Y
----
L
F
-
I
C
K
G
K
I
P
A
Y
L
-
G
S
S
F
A
F
-
I
S
P
V
-----
L
L
L
L
----
P
-
L
-
G
Y
E
V
------
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
-----
G
W
L
--------
D
V
L
F
P
P
A
----
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
-
A
G
L
-----
L
P
---
A
E
-----------
G
Q
T
-
P
D
S
K
-------------
T
I
-
I
I
S
I
-
T
T
L
-
A
V
T
V
L
G
S
--
V
L
FRGFL
A
-----------
I
I
--
P
I
---
L
-
I
-----------
G
V
L
V
-
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
P
I
I
N
A
H
W
F
A
L
-----
P
T
L
Y
T
---
P
---
R
F
-------
E
--------
W
F
A
I
L
T
I
--
L
----------
P
A
A
L
V
V
I
--
A
E
H
V
G
H
L
V
V
T
A
N
I
V
-
K
--
K
-
D
L
L
R
D
-
P
G
L
H
R
S
M
F
A
N
G
L
S
T
---
V
I
S
G
F
F
G
S
T
P
N
T
-----
T
-
Y
G
E
N
I
G
V
M
A
I
T
----
R
V
-----
Y
S
T
W
V
I
G
G
A
A
I
F
----
A
I
L
----
L
-
S
C
V
G
K
L
A
A
A
I
Q
M
I
-
P
L
P
V
M
G
G
---
V
S
L
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
51.97
13%
-141
- C6 -
1IOK
-
CH60_PARDE
A:
[2-526]
---
A
A
K
E
V
K
F
---
N
S
D
A
R
D
R
M
L
K
G
V
N
I
L
A
D
A
V
--
K
V
T
L
--
G
P
K
G
R
N
V
V
I
D
K
S
F
G
A
P
R
I
T
K
D
G
V
S
V
A
K
E
I
ELSD
K
F
E
N
M
G
A
Q
M
V
----
R
E
-
V
-
A
-
S
R
T
N
D
E
-
A
G
D
G
T
T
T
A
T
V
L
-----
A
Q
A
I
V
-
R
E
G
-
L
-
K
A
V
A
A
GMN
P
M
D
L
K
R
G
I
D
V
A
T
A
K
V
V
E
A
I
K
----
S
A
-
A
---
R
P
V
ND
S
S
E
V
A
Q
V
G
T
I
S
A
N
----
G
E
S
F
I
G
Q
Q
I
A
E
A
M
Q
R
V
G
N
E
G
-
V
I
T
-----
V
E
E
N
K
G
M
E
T
----
E
-
V
E
V
V
E
G
-
M
Q
F
D
-------------
R
G
-
Y
L
S
P
-
Y
F
V
-
T
N
A
D
K
M
I
--
A
E
-----
L
-----------
E
D
--
A
Y
---
I
L
L
H
EKKLSSLQPQ
K
P
L
L
-
I
V
A
E
D
V
E
I
A
A
V
K
A
P
GFG-
D
R
R
K
A
M
L
Q
D
I
A
I
L
T
G
G
--------
I
-------
D
M
L
----
G
R
A
K
K
V
S
I
N
KD
N
----------
T
T
I
V
D
G
A
--
G
E
K
A
E
I
E
A
R
V
S
Q
I
R
-
Q
--
Q
I
E
E
T
T
S
-
D
Y
D
R
E
K
L
Q
E
R
V
A
K
L
A
G
G
V
A
V
I
R
V
G
G
M
T
E
I
-----
E
-
V
-
K
E
R
K
D
R
V
D
D
----
A
L
-----
N
A
T
R
A
A
V
Q
E
G
I
V
VGGG
V
A
L
----
V
-
Q
G
---
A
K
V
L
E
G
L
S
G
A
N
S
D
Q
D
A
---
G
I
A
I
I
R
R
A
L
E
A
--
P
M
R
----
Q
I
A
-
E
N
A
GV
D
G
A
V
----
V
A
--
G
K
V
R
E
S
S
D
K
A
F
G
F
N
A
-
Q
T
E
----
E
Y
G
--
D
M
F
-
K
F
G
V
I
D
---------
P
A
K
V
V
R
---
T
-
A
L
E
D
A
A
S
V
-----
A
G
L
L
I
--
T
T
E
-----
A
M
I
A
E
K
P
--------------
19
HHSearch
51.73
15%
-144
- C7 -
4YZF
1
B3AT_HUMAN
A:
[384-801]
-------
R
D
I
R
R
R
Y
P
Y
Y
L
S
D
I
T
D
A
F
S
P
Q
V
L
A
A
V
I
F
I
Y
F
A
A
L
S
P
A
I
T
F
G
G
L
L
G
E
K
----
T
R
N
Q
M
G
V
S
E
L
L
----
I
S
T
A
V
Q
G
I
L
F
----
A
L
-
L
-
G
-
A
Q
P
L
L
V
V
G
F
S
G
P
L
-
L
V
F
E
E
A
F
--
F
S
F
C
E
-
T
N
G
L
E
-
Y
I
V
G
------
R
V
W
I
G
F
W
L
I
L
L
V
V
L
V
V
A
F
----
E
G
-----
S
F
L
--------
V
R
F
I
S
R
Y
----
T
Q
E
I
F
S
F
L
I
S
L
I
F
I
Y
E
T
F
S
K
L
I
K
I
-----
F
Q
---
D
H
P
L
Q
K
T
Y-----
L
P
N
-
T
A
L
L
-------------
S
L
-
V
L
M
A
-
G
T
F
-
F
F
A
M
M
L
R
--
K
F
-----
K
N
SSYFPG
K
L
R
R
V
I
G
D
F
G
---
V
P
I
-----------
S
I
L
I
-
M
V
L
V
D
F
F
I
Q
D
T
Y
T
Q
------
K
L
S
V
P
D
G
F
K
V
--
V
I
H
P
L
G
LRS
E
F
-------
P
I
W
----
M
M
F
A
S
A
L
P
A
--
L
----------
L
V
F
I
L
I
F
--
L
E
S
Q
I
T
T
L
I
V
S
K
P
E
-
R
----
K
M
V
K
G
-
S
G
F
H
L
D
L
L
L
V
V
G
M
G
---
G
V
A
A
L
F
G
M
P
W
L
S
-----
A
T
T
-
V
R
S
V
T
H
A
N
A
L
TVM--I
Q
E
V
K
E
Q
R
I
S
G
L
L
V
A
V
L
----
V
G
L
----
S
-
I
L
---
M
E
P
I
L
S
R
I
-
P
L
A
V
L
F
G
---
I
F
L
Y
M
G
V
T
S
L
S
-----------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
48.01
19%
-99
- C2 -
4O6D
8
?
A:
[19-377]
-----
L
Y
F
Q
S
N
A
-
D
T
G
C
A
I
D
I
S
R
Q
E
L
R
C
G
S
G
V
--
F
I
H
---
N
D
V
E
A
W
M
D
R
Y
K
Y
Y
P
E
T
---
P
Q
G
L
A
K
I
I
Q
K
----
A
H
K
E
G
V
C
G
L
R
----
S
V
S
R
-
L
-
E
H
Q
M
W
E
-
A
V
K
D
E
L
N
T
L
L
K
E
N
GVD
L
S
V
V
V
-
E
---------------
K
Q
E
G
M
Y
K
S
----
A
P
K
R
L
T
----
A
T
-
A
---
N
N
T
--------
F
V
V
D
G
P
E
----
T
K
E
C
P
T
Q
N
R
A
W
N
S
L
E
V
E
D
F
G
-
F
G
L
----------
T
S
T
R
----
M
-
F
L
K
V
R
E
-
S
N
T
T
-------------
E
C
-
D
S
K
I
-
I
G
T
-
A
V
K
-
N
N
L
--
A
I
-----
H
-----------
S
D
--
L
S
---
Y
W
I
-----------
E
S
R
L
-
N
-------
D
T
W
K
L
E
----
R
A
V
L
G
E
V
K
S
C
--
T
W
P
E
T
-
H
T
---
L
W
-------
G
D
G
----
I
L
E
S
D
L
I
I
P
--
V
----------
T
L
----------
A
G
P
R
S
N
H
N
R
R
P
-
G
--
Y
K
T
Q
N
Q
G
-
P
-----
W
D
E
G
R
V
E
I
---
D
F
D
Y
C
P
G
T
T
V
T
L
-----
S
-
E
-
S
C
G
H
R
G
P
A
T
----
R
T
-----
T
T
E
S
G
K
L
I
T
--------------------------
D
W
C
-
C
R
S
C
T
L
P
-----------------------------------------------------
P
L
R
Y
Q
T
-
D
S
G
----
C
W
Y
--
G
M
-------
E
---------
I
R
P
Q
R
H
---
D
-
E
K
T
L
V
--
Q
-----
S
Q
V
N
A
-------------------------------
24
HHSearch
42.77
42%
-372
- C5 -
4XTR
-
?
G:
[15-33]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
R
--
V
-----
Y
L
L
I
V
L-
L
V
M
-----
L
L
F
I
F
L
---------------
6
PsiBlast_PDB
32.53
27%
-137
- C5 -
4KG7
-
?
A:
[274-377]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
M
A
G
P
W
V
G
I
A
A
P
G
E
N
--
I
V
S
V
S
N
A
-
P
D
G
G
L
S
N
A
L
P
S
E
R
D
---
R
L
V
P
L
T
G
T
S
Y
A
A
-----
A
-
Y
-
V
---
S
G
V
A
A
----
L
V
-----
R
S
K
F
P
D
L
T
A
--------------
R
-
Q
V
---
V
H
R
L
T
T
T
A
-
Q
G
A
A
R
S
P
---
S
N
L
I
-
G
A
G
M
V
D
--
P
V
A
----
A
L
T
-
W
D
--------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_CBE
32.32
31%
-149
- C5 -
3OFU
1
?
F:
[20-97]
------------------------------------------------------------------------------------------------------
P
G
V
E
Q
D
Y
F
A
A
-----
W
K
T
L
L
D
G
P
G
-
L
-
V
W
S
T
------
A
N
G
G
H
W
I
A
A
R
G
D
V
V
R
E
L
W
----
G
D
-
A
---
E
R
L
--------
S
S
Q
C
---------
L
A
V
T
P
G
L
G
K
V
M
Q
F
I
P
L
Q
Q
-
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_CBE
31.78
31%
-138
- C5 -
3OFU
2
?
C:
[20-91]
------------------------------------------------------------------------------------------------------
P
G
V
E
Q
D
Y
F
A
A
-----
W
K
T
L
L
D
G
P
G
-
L
-
V
W
S
T
------
A
N
G
G
H
W
I
A
A
R
G
D
V
V
R
E
L
W
----
G
D
-
A
---
E
R
L
--------
S
S
Q
C
---------
L
A
V
T
P
G
L
G
K
V
M
Q
F
I
P
L
Q
Q
-
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_CBE
31.26
31%
-137
- C5 -
3OFT
2
?
C:
[20-97]
------------------------------------------------------------------------------------------------------
P
G
V
E
Q
D
Y
F
A
A
-----
W
K
T
L
L
D
G
P
G
-
L
-
V
W
S
T
------
A
N
G
G
H
W
I
A
A
R
G
D
V
V
R
E
L
W
----
G
D
-
A
---
E
R
L
--------
S
S
Q
C
---------
L
A
V
T
P
G
L
G
K
V
M
Q
F
I
P
L
Q
Q
-
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_CBE
31.09
31%
-128
- C5 -
3OFU
1
?
D:
[20-93]
------------------------------------------------------------------------------------------------------
P
G
V
E
Q
D
Y
F
A
A
-----
W
K
T
L
L
D
G
P
G
-
L
-
V
W
S
T
------
A
N
G
G
H
W
I
A
A
R
G
D
V
V
R
E
L
W
----
G
D
-
A
---
E
R
L
--------
S
S
Q
C
---------
L
A
V
T
P
G
L
G
K
V
M
Q
F
I
P
L
Q
Q
-
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_CBE
30.88
31%
-145
- C5 -
3OFU
1
?
E:
[20-97]
------------------------------------------------------------------------------------------------------
P
G
V
E
Q
D
Y
F
A
A
-----
W
K
T
L
L
D
G
P
G
-
L
-
V
W
S
T
------
A
N
G
G
H
W
I
A
A
R
G
D
V
V
R
E
L
W
----
G
D
-
A
---
E
R
L
--------
S
S
Q
C
---------
L
A
V
T
P
G
L
G
K
V
M
Q
F
I
P
L
Q
Q
-
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_CBE
30.84
31%
-132
- C5 -
3OFT
1
?
B:
[20-94]
------------------------------------------------------------------------------------------------------
P
G
V
E
Q
D
Y
F
A
A
-----
W
K
T
L
L
D
G
P
G
-
L
-
V
W
S
T
------
A
N
G
G
H
W
I
A
A
R
G
D
V
V
R
E
L
W
----
G
D
-
A
---
E
R
L
--------
S
S
Q
C
---------
L
A
V
T
P
G
L
G
K
V
M
Q
F
I
P
L
Q
Q
-
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_CBE
30.83
31%
-130
- C5 -
3OFU
2
?
B:
[20-91]
------------------------------------------------------------------------------------------------------
P
G
V
E
Q
D
Y
F
A
A
-----
W
K
T
L
L
D
G
P
G
-
L
-
V
W
S
T
------
A
N
G
G
H
W
I
A
A
R
G
D
V
V
R
E
L
W
----
G
D
-
A
---
E
R
L
--------
S
S
Q
C
---------
L
A
V
T
P
G
L
G
K
V
M
Q
F
I
P
L
Q
Q
-
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
30.67
31%
-130
- C5 -
3OFT
2
?
A:
[20-91]
------------------------------------------------------------------------------------------------------
P
G
V
E
Q
D
Y
F
A
A
-----
W
K
T
L
L
D
G
P
G
-
L
-
V
W
S
T
------
A
N
G
G
H
W
I
A
A
R
G
D
V
V
R
E
L
W
----
G
D
-
A
---
E
R
L
--------
S
S
Q
C
---------
L
A
V
T
P
G
L
G
K
V
M
Q
F
I
P
L
Q
Q
-
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------