@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06440: (2016-06-10 )
MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKEDVKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTALSYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEEMKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDRHADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSENMTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNLTVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFRELVEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA
Atome Classification :
(20 SA)
.........10........20........30........-40........50-.--.......60........70........80-.-.----.......90........100.......110.......120.......130.......140.......150.......160.......170........180.......190-.----.------.---......200.....-..210.......220.......230.......240.......250.......260.......270.......280.......290...-....300.......310.......320.......330.......340.......350.......360.......--370.....-..380.......------..390......--.400..--.....410.......----420.......430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIERYSRPE
M
S
A
I
WTDE
N
R
F
Q
A
W
L
E
V
E
I
L
A
C
E
A
W
A
ELGV-I
P
K
E
D
V
K
V
M
R
EN-A--SF
D
I
N
R
I
L
E
IEKDTR
H
D
V
V
A
F
T
R
A
V
S
E
S
--L-G----EE
R
K
W
V
H
YGL
T
S
T
D
V
V
D
T
A
L
S
Y
L
L
K
QA
N
D
I
L
L
K
D
L
E
R
F
V
D
I
I
K
E
K
A
KEH
K
Y
T
V
M
MGRTHGVHAEPTTF
G
L
K
L
A
L
W
H
E
E
M
K
R
N
L
E
R
F
K
Q
-
A
KAG
I
E
V
GKISGAVGTYAN
I
---
D
----
P
------
F
---
V
E
Q
Y
V
C
E
KLGLKAA-PI
S
T
Q
T
L
Q
R
D
R
H
A
D
Y
M
A
T
L
A
L
I
A
T
S
I
E
K
F
A
V
E
I
RGLQK
S
E
T
R
E
V
E
E
F
F
AKGQKGSSAMPHKRNPIGSE
N
M
T
G
M
A
R
V
I
R
G
Y
M
M
T
A
YENV-PLWHERDISHSSA
E
R
I
ILP
D
A
T
I
A
L
N
Y
M
L
N
R
F
S
N
I
V
K
NLTVF
P
E
N
M
K
R
N
M
D
R
T
L
G
L
I
Y
S
Q
R
V
L
L
A
L
I
DTGL
T
R
E
--
E
AYDTVQ
P
-
K
A
M
--
E
A
W
E
KQV------
P
F
R
E
L
V
E
A
E
E
K
--
I
T
SRL
S
--
P
E
K
I
A
D
C
FDYNYHLK----
N
V
D
L
I
F
E
R
LGLA-
34
HHSearch
95.55
84%
-93
- C3 -
2PFM
3
?
A:
[11-439]
-
I
S
R
Y
T
R
P
E
M
G
A
I
W
T
E
E
N
K
F
K
A
W
L
E
V
E
I
L
A
C
E
A
W
A
E
L
G
D
-
I
P
K
E
D
V
K
K
I
R
E
H
-
A
--
S
F
D
I
D
R
I
Y
E
I
E
K
E
T
R
H
D
V
V
A
F
T
R
A
V
S
E
T
PA
L
-
G
----
E
E
R
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
Y
I
L
K
Q
A
N
E
I
I
L
K
D
L
E
N
F
V
S
I
L
A
N
K
A
K
E
H
K
Y
T
I
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
L
K
L
G
L
W
Y
E
E
M
K
R
N
V
E
R
F
K
Q
-
A
A
N
T
V
R
V
G
K
L
S
G
A
V
G
T
Y
A
N
I
---
D
----
P
------
F
---
V
E
K
Y
V
C
E
N
L
G
L
E
A
A
-
P
I
S
T
Q
T
L
Q
R
D
R
H
A
H
Y
M
S
T
L
A
L
I
A
T
S
I
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K
M
A
V
E
I
R
G
L
Q
K
S
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
M
T
G
L
A
R
V
I
R
G
Y
M
M
T
A
Y
E
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
V
I
L
P
D
A
T
I
A
L
N
Y
M
L
N
R
F
G
N
I
V
K
N
L
T
V
Y
P
E
N
M
K
R
N
M
T
R
T
Y
G
L
I
Y
S
Q
R
V
M
L
T
L
I
D
K
G
M
V
R
E
--
E
A
Y
D
I
V
Q
P
-
K
A
M
--
E
A
W
E
T
Q
V
------
Q
F
K
E
L
V
E
A
D
E
R
--
I
T
S
K
L
T
--
Q
E
E
I
N
E
C
F
N
Y
E
H
H
M
Q
----
H
V
D
T
I
F
E
R
L
----
2
PsiBlast_PDB
95.35
83%
-94
- C3 -
2PFM
3
?
A:
[11-441]
-
I
S
R
Y
T
R
P
E
M
G
A
I
W
T
E
E
N
K
F
K
A
W
L
E
V
E
I
L
A
C
E
A
W
A
E
L
G
D
-
I
P
K
E
D
V
K
K
I
R
E
H
-
A
--
S
F
D
I
D
R
I
Y
E
I
E
K
E
T
R
H
D
V
V
A
F
T
R
A
V
S
E
T
PA
L
-
G
----
E
E
R
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
Y
I
L
K
Q
A
N
E
I
I
L
K
D
L
E
N
F
V
S
I
L
A
N
K
A
K
E
H
K
Y
T
I
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
L
K
L
G
L
W
Y
E
E
M
K
R
N
V
E
R
F
K
Q
-
A
A
N
T
V
R
V
G
K
L
S
G
A
V
G
T
Y
A
N
I
---
D
----
P
------
F
---
V
E
K
Y
V
C
E
N
L
G
L
E
A
A
-
P
I
S
T
Q
T
L
Q
R
D
R
H
A
H
Y
M
S
T
L
A
L
I
A
T
S
I
E
K
M
A
V
E
I
R
G
L
Q
K
S
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
M
T
G
L
A
R
V
I
R
G
Y
M
M
T
A
Y
E
N
V
-
P
L
W
H
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R
D
I
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S
S
A
E
R
V
I
L
P
D
A
T
I
A
L
N
Y
M
L
N
R
F
G
N
I
V
K
N
L
T
V
Y
P
E
N
M
K
R
N
M
T
R
T
Y
G
L
I
Y
S
Q
R
V
M
L
T
L
I
D
K
G
M
V
R
E
--
E
A
Y
D
I
V
Q
P
-
K
A
M
--
E
A
W
E
T
Q
V
------
Q
F
K
E
L
V
E
A
D
E
R
--
I
T
S
K
L
T
--
Q
E
E
I
N
E
C
F
N
Y
E
H
H
M
Q
----
H
V
D
T
I
F
E
R
L
G
L
--
21
PsiBlast_CBE
94.48
83%
-91
- C3 -
2PFM
2
?
B:
[11-441]
-
I
S
R
Y
T
R
P
E
M
G
A
I
W
T
E
E
N
K
F
K
A
W
L
E
V
E
I
L
A
C
E
A
W
A
E
L
G
D
-
I
P
K
E
D
V
K
K
I
R
E
H
-
A
--
S
F
D
I
D
R
I
Y
E
I
E
K
E
T
R
H
D
V
V
A
F
T
R
A
V
S
E
T
PA
L
-
G
----
E
E
R
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
Y
I
L
K
Q
A
N
E
I
I
L
K
D
L
E
N
F
V
S
I
L
A
N
K
A
K
E
H
K
Y
T
I
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
L
K
L
G
L
W
Y
E
E
M
K
R
N
V
E
R
F
K
Q
-
A
A
N
T
V
R
V
G
K
L
S
G
A
V
G
T
Y
A
N
I
---
D
----
P
------
F
---
V
E
K
Y
V
C
E
N
L
G
L
E
A
A
-
P
I
S
T
Q
T
L
Q
R
D
R
H
A
H
Y
M
S
T
L
A
L
I
A
T
S
I
E
K
M
A
V
E
I
R
G
L
Q
K
S
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
M
T
G
L
A
R
V
I
R
G
Y
M
M
T
A
Y
E
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
V
I
L
P
D
A
T
I
A
L
N
Y
M
L
N
R
F
G
N
I
V
K
N
L
T
V
Y
P
E
N
M
K
R
N
M
T
R
T
Y
G
L
I
Y
S
Q
R
V
M
L
T
L
I
D
K
G
M
V
R
E
--
E
A
Y
D
I
V
Q
P
-
K
A
M
--
E
A
W
E
T
Q
V
------
Q
F
K
E
L
V
E
A
D
E
R
--
I
T
S
K
L
T
--
Q
E
E
I
N
E
C
F
N
Y
E
H
H
M
Q
----
H
V
D
T
I
F
E
R
L
G
L
--
3
PsiBlast_PDB
87.53
74%
-82
- C3 -
2X75
4
PUR8_STAAW
A:
[2-431]
-
I
E
R
Y
S
R
E
E
M
S
N
I
W
T
D
Q
N
R
Y
E
A
W
L
E
V
E
I
L
A
C
E
A
W
S
E
L
G
H
-
I
P
K
A
D
V
Q
K
I
R
Q
N
-
A
--
K
V
N
V
E
R
A
Q
E
I
E
Q
E
T
R
H
D
V
V
A
F
T
R
Q
V
S
E
T
--
L
-
G
----
E
E
R
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
F
V
I
K
Q
A
N
D
I
I
E
K
D
L
E
R
F
I
D
V
L
A
E
K
A
K
N
Y
K
Y
T
L
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
V
K
M
A
L
W
Y
T
E
M
Q
R
N
L
Q
R
F
K
Q
-
V
R
E
E
I
E
V
G
K
M
S
G
A
V
G
T
F
A
N
I
---
P
----
P
------
E
---
I
E
S
Y
V
C
K
H
L
G
I
G
T
A
-
P
V
S
T
Q
T
L
Q
R
D
R
H
A
Y
Y
I
A
T
L
A
L
I
A
T
S
L
E
K
F
A
V
E
I
R
N
L
Q
K
T
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
I
T
G
I
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R
V
I
R
G
Y
I
T
T
A
Y
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N
V
-
P
L
W
H
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D
I
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S
S
A
E
R
I
M
L
P
D
V
T
I
A
L
D
Y
A
L
N
R
F
T
N
I
V
D
R
L
T
V
F
E
D
N
M
R
N
N
I
D
K
T
F
G
L
I
F
S
Q
R
V
L
L
A
L
I
N
K
G
M
V
R
E
--
E
A
Y
D
K
V
Q
P
-
K
A
M
--
I
S
W
E
T
K
T
------
P
F
R
E
L
I
E
Q
D
E
S
--
I
T
---
T
--
K
E
E
L
D
E
C
F
D
P
K
H
H
L
N
----
Q
V
D
T
I
F
E
R
A
G
L
A
-
4
PsiBlast_PDB
82.35
51%
-96
- C3 -
1C3U
2
PUR8_THEMA
A:
[2-428]
-
V
E
R
Y
S
L
S
P
M
K
D
L
W
T
E
E
A
K
Y
R
R
W
L
E
V
E
L
A
V
T
R
A
Y
E
E
L
G
M
-
I
P
K
G
V
T
E
R
I
R
N
N
-
A
--
K
I
D
V
E
L
F
K
K
I
E
E
K
T
N
H
D
V
V
A
F
V
E
G
I
G
S
M
--
I
-
G
----
E
D
S
R
F
F
H
Y
G
L
T
S
S
D
V
L
D
T
A
N
S
L
A
L
V
E
A
G
K
I
L
L
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S
L
K
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F
C
D
V
L
W
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A
N
R
Y
K
H
T
P
T
I
G
R
T
H
G
V
H
A
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P
T
S
F
G
L
K
V
L
G
W
Y
S
E
M
K
R
N
V
Q
R
L
E
R
-
A
I
E
E
V
S
Y
G
K
I
S
G
A
V
G
N
Y
A
N
V
---
P
----
P
------
E
---
V
E
E
K
A
L
S
Y
L
G
L
K
P
E
-
P
V
S
T
Q
V
V
P
R
D
R
H
A
F
Y
L
S
T
L
A
I
V
A
A
G
I
E
R
I
A
V
E
I
R
H
L
Q
R
T
E
V
L
E
V
E
E
P
F
R
------
S
A
M
P
H
K
K
N
P
I
T
C
E
R
L
T
G
L
S
R
M
M
R
A
Y
V
D
P
S
L
E
N
I
-
A
L
W
H
E
R
D
I
S
H
S
S
V
E
R
Y
V
F
P
D
A
T
Q
T
L
Y
Y
M
I
V
T
A
T
N
V
V
R
N
M
K
V
N
E
E
R
M
K
K
N
I
D
L
T
K
G
L
V
F
S
Q
R
V
L
L
K
L
I
E
K
G
L
T
R
K
--
E
A
Y
D
I
V
Q
R
-
N
A
L
--
K
T
W
N
S
E
K
------
H
F
L
E
Y
L
L
E
D
E
E
--
V
K
K
L
V
T
--
K
E
E
L
E
E
L
F
D
I
S
Y
Y
L
K
----
H
V
D
H
I
F
E
R
F
----
33
HHSearch
82.19
51%
-92
- C3 -
1C3C
-
PUR8_THEMA
A:
[3-428]
--
E
R
Y
S
L
S
P
M
K
D
L
W
T
E
E
A
K
Y
R
R
W
L
E
V
E
L
A
V
T
R
A
Y
E
E
L
G
M
-
I
P
K
G
V
T
E
R
I
R
N
N
-
A
--
K
I
D
V
E
L
F
K
K
I
E
E
K
T
N
H
D
V
V
A
F
V
E
G
I
G
S
M
--
I
-
G
----
E
D
S
R
F
F
H
Y
G
L
T
S
S
D
V
L
D
T
A
N
S
L
A
L
V
E
A
G
K
I
L
L
E
S
L
K
E
F
C
D
V
L
W
E
V
A
N
R
Y
K
H
T
P
T
I
G
R
T
H
G
V
H
A
E
P
T
S
F
G
L
K
V
L
G
W
Y
S
E
M
K
R
N
V
Q
R
L
E
R
-
A
I
E
E
V
S
Y
G
K
I
S
G
A
V
G
N
Y
A
N
V
---
P
----
P
------
E
---
V
E
E
K
A
L
S
Y
L
G
L
K
P
E
-
P
V
S
T
Q
V
V
P
R
D
R
H
A
F
Y
L
S
T
L
A
I
V
A
A
G
I
E
R
I
A
V
E
I
R
H
L
Q
R
T
E
V
L
E
V
E
E
P
F
R
K
-----
S
A
M
P
H
K
K
N
P
I
T
C
E
R
L
T
G
L
S
R
M
M
R
A
Y
V
D
P
S
L
E
N
I
-
A
L
W
H
E
R
D
I
S
H
S
S
V
E
R
Y
V
F
P
D
A
T
Q
T
L
Y
Y
M
I
V
T
A
T
N
V
V
R
N
M
K
V
N
E
E
R
M
K
K
N
I
D
L
T
K
G
L
V
F
S
Q
R
V
L
L
K
L
I
E
K
G
L
T
R
K
--
E
A
Y
D
I
V
Q
R
-
N
A
L
--
K
T
W
N
S
E
K
------
H
F
L
E
Y
L
L
E
D
E
E
--
V
K
K
L
V
T
--
K
E
E
L
E
E
L
F
D
I
S
Y
Y
L
K
----
H
V
D
H
I
F
E
R
F
----
5
PsiBlast_PDB
82.09
51%
-92
- C3 -
1C3C
-
PUR8_THEMA
A:
[2-428]
-
V
E
R
Y
S
L
S
P
M
K
D
L
W
T
E
E
A
K
Y
R
R
W
L
E
V
E
L
A
V
T
R
A
Y
E
E
L
G
M
-
I
P
K
G
V
T
E
R
I
R
N
N
-
A
--
K
I
D
V
E
L
F
K
K
I
E
E
K
T
N
H
D
V
V
A
F
V
E
G
I
G
S
M
--
I
-
G
----
E
D
S
R
F
F
H
Y
G
L
T
S
S
D
V
L
D
T
A
N
S
L
A
L
V
E
A
G
K
I
L
L
E
S
L
K
E
F
C
D
V
L
W
E
V
A
N
R
Y
K
H
T
P
T
I
G
R
T
H
G
V
H
A
E
P
T
S
F
G
L
K
V
L
G
W
Y
S
E
M
K
R
N
V
Q
R
L
E
R
-
A
I
E
E
V
S
Y
G
K
I
S
G
A
V
G
N
Y
A
N
V
---
P
----
P
------
E
---
V
E
E
K
A
L
S
Y
L
G
L
K
P
E
-
P
V
S
T
Q
V
V
P
R
D
R
H
A
F
Y
L
S
T
L
A
I
V
A
A
G
I
E
R
I
A
V
E
I
R
H
L
Q
R
T
E
V
L
E
V
E
E
P
F
R
K
-----
S
A
M
P
H
K
K
N
P
I
T
C
E
R
L
T
G
L
S
R
M
M
R
A
Y
V
D
P
S
L
E
N
I
-
A
L
W
H
E
R
D
I
S
H
S
S
V
E
R
Y
V
F
P
D
A
T
Q
T
L
Y
Y
M
I
V
T
A
T
N
V
V
R
N
M
K
V
N
E
E
R
M
K
K
N
I
D
L
T
K
G
L
V
F
S
Q
R
V
L
L
K
L
I
E
K
G
L
T
R
K
--
E
A
Y
D
I
V
Q
R
-
N
A
L
--
K
T
W
N
S
E
K
------
H
F
L
E
Y
L
L
E
D
E
E
--
V
K
K
L
V
T
--
K
E
E
L
E
E
L
F
D
I
S
Y
Y
L
K
----
H
V
D
H
I
F
E
R
F
----
22
PsiBlast_CBE
82.05
51%
-95
- C3 -
1C3U
2
PUR8_THEMA
B:
[2-428]
-
V
E
R
Y
S
L
S
P
M
K
D
L
W
T
E
E
A
K
Y
R
R
W
L
E
V
E
L
A
V
T
R
A
Y
E
E
L
G
M
-
I
P
K
G
V
T
E
R
I
R
N
N
-
A
--
K
I
D
V
E
L
F
K
K
I
E
E
K
T
N
H
D
V
V
A
F
V
E
G
I
G
S
M
--
I
-
G
----
E
D
S
R
F
F
H
Y
G
L
T
S
S
D
V
L
D
T
A
N
S
L
A
L
V
E
A
G
K
I
L
L
E
S
L
K
E
F
C
D
V
L
W
E
V
A
N
R
Y
K
H
T
P
T
I
G
R
T
H
G
V
H
A
E
P
T
S
F
G
L
K
V
L
G
W
Y
S
E
M
K
R
N
V
Q
R
L
E
R
-
A
I
E
E
V
S
Y
G
K
I
S
G
A
V
G
N
Y
A
N
V
---
P
----
P
------
E
---
V
E
E
K
A
L
S
Y
L
G
L
K
P
E
-
P
V
S
T
Q
V
V
P
R
D
R
H
A
F
Y
L
S
T
L
A
I
V
A
A
G
I
E
R
I
A
V
E
I
R
H
L
Q
R
T
E
V
L
E
V
E
E
P
F
R
------
S
A
M
P
H
K
K
N
P
I
T
C
E
R
L
T
G
L
S
R
M
M
R
A
Y
V
D
P
S
L
E
N
I
-
A
L
W
H
E
R
D
I
S
H
S
S
V
E
R
Y
V
F
P
D
A
T
Q
T
L
Y
Y
M
I
V
T
A
T
N
V
V
R
N
M
K
V
N
E
E
R
M
K
K
N
I
D
L
T
K
G
L
V
F
S
Q
R
V
L
L
K
L
I
E
K
G
L
T
R
K
--
E
A
Y
D
I
V
Q
R
-
N
A
L
--
K
T
W
N
S
E
K
------
H
F
L
E
Y
L
L
E
D
E
E
--
V
K
K
L
V
T
--
K
E
E
L
E
E
L
F
D
I
S
Y
Y
L
K
----
H
V
D
H
I
F
E
R
F
----
1
PsiBlast_PDB
76.90
100%
-
- C3 -
1F1O
-
PUR8_BACSU
A:
[9-416]
--------
E
M
S
A
I
W
T
D
E
N
R
F
Q
A
W
L
E
V
E
I
L
A
C
E
A
W
A
E
L
G
V
-
I
P
K
E
D
V
K
V
M
R
E
N
-
A
--
S
F
D
I
N
R
I
L
E
I
E
K
D
T
R
H
D
V
V
A
F
T
R
A
V
S
E
S
--
L
-
G
----
E
E
R
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
Y
L
L
K
Q
A
N
D
I
L
L
K
D
L
E
R
F
V
D
I
I
K
E
K
A
K
E
H
K
Y
T
V
M
M
--
T
H
G
V
H
A
E
P
T
T
F
G
L
K
L
A
L
W
H
E
E
M
K
R
N
L
E
R
F
K
Q
-
A
K
A
G
I
E
V
G
K
I
S
G
------
N
I
---
D
----
P
------
F
---
V
E
Q
Y
V
C
E
K
L
G
L
K
A
A
-
P
I
S
T
Q
T
L
Q
R
D
R
H
A
D
Y
M
A
T
L
A
L
I
A
T
S
I
E
K
F
A
V
E
I
R
G
L
Q
K
S
E
T
R
E
V
E
E
F
--------
S
A
M
P
H
K
R
N
P
I
G
S
E
N
M
T
G
M
A
R
V
I
R
G
Y
M
M
T
A
Y
E
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
I
I
L
P
D
A
T
I
A
L
N
Y
M
L
N
R
F
S
N
I
V
K
N
L
T
V
F
P
E
N
M
K
R
N
------
L
I
Y
S
Q
R
V
L
L
A
----------------------------------------------
E
E
K
--
I
T
S
R
L
S
--
P
E
K
I
A
D
C
F
D
Y
N
Y
--------------------
23
PsiBlast_CBE
76.22
40%
-102
- C3 -
5HW2
4
?
D:
[1-428]
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
-
E
D
R
M
-
V
P
K
G
T
A
A
E
I
R
A
R
-
A
--
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
T
A
----
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
-
Q
F
S
G
A
V
G
N
Y
C
I
L
---
T
----
T
------
E
---
D
E
K
K
A
A
D
I
L
G
L
P
V
E
-
E
V
S
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
S
K
G
-------
P
H
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
--
D
C
Y
K
I
V
Q
Q
-
V
----
E
S
F
S
K
K
L
--------
Q
K
V
M
H
D
E
H
N
--
I
I
L
D
I
---
P
E
M
D
F
E
G
I
K
K
T
Y
-
L
K
----
E
I
D
H
V
F
D
R
-----
24
PsiBlast_CBE
75.41
40%
-92
- C3 -
5HW2
7
?
C:
[1-428]
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
-
E
D
R
--
V
P
K
G
T
A
A
E
I
R
A
R
-
A
--
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
T
A
----
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
-
Q
F
S
G
A
V
G
N
Y
C
I
L
---
T
----
T
------
E
---
D
E
K
K
A
A
D
I
L
G
L
P
V
E
-
E
V
S
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
--
G
Q
K
G
S
S
T
M
P
H
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
--
D
C
Y
K
I
V
Q
Q
-
V
--G-
E
S
F
S
K
K
L
--------
Q
K
V
M
H
D
E
H
N
--
I
I
L
D
I
---
P
E
M
D
F
E
G
I
K
K
T
Y
-
L
K
----
E
I
D
H
V
F
D
R
-----
6
PsiBlast_PDB
75.27
40%
-98
- C3 -
4EEI
12
?
A:
[1-428]
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
-
E
D
R
M
-
V
P
K
G
T
A
A
E
I
R
A
R
-
A
--
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
T
A
----
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
-
Q
F
S
G
A
V
G
N
Y
C
I
L
---
T
----
T
------
E
---
D
E
K
K
A
A
D
I
L
G
L
P
V
E
-
E
V
S
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
------------
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
--
D
C
Y
K
I
V
Q
Q
-
V
----
E
S
F
S
K
K
L
--------
Q
K
V
M
H
D
E
H
N
--
I
I
L
D
I
---
P
E
M
D
F
E
G
I
K
K
T
Y
-
L
K
----
E
I
D
H
V
F
D
R
-----
26
PsiBlast_CBE
75.12
40%
-99
- C3 -
4EEI
17
?
B:
[1-428]
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
-
E
D
R
M
-
V
P
K
G
T
A
A
E
I
R
A
R
-
A
--
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
T
A
----
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
-
Q
F
S
G
A
V
G
N
Y
C
I
L
---
T
----
T
------
E
---
D
E
K
K
A
A
D
I
L
G
L
P
V
E
-
E
V
S
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
------------
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
--
D
C
Y
K
I
V
Q
Q
-
V
A
F
DL
E
S
F
S
K
K
L
--------
Q
K
V
M
H
D
E
H
N
--
I
I
L
D
I
---
P
E
M
D
F
E
G
I
K
K
T
Y
-
L
K
----
E
I
D
H
V
F
D
R
-----
7
PsiBlast_PDB
74.82
40%
-98
- C3 -
5HW2
6
?
A:
[1-428]
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
-
E
D
R
M
-
V
P
K
G
T
A
A
E
I
R
A
R
-
A
--
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
T
A
----
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
-
Q
F
S
G
A
V
G
N
Y
C
I
L
---
T
----
T
------
E
---
D
E
K
K
A
A
D
I
L
G
L
P
V
E
-
E
V
S
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
------------
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
--
D
C
Y
K
I
V
Q
Q
-
V
----
E
S
F
S
K
K
L
--------
Q
K
V
M
H
D
E
H
N
--
I
I
L
D
I
---
P
E
M
D
F
E
G
I
K
K
T
Y
-
L
K
----
E
I
D
H
V
F
D
R
-----
25
PsiBlast_CBE
74.61
40%
-102
- C3 -
5HW2
5
?
B:
[1-428]
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
-
E
D
R
M
-
V
P
K
G
T
A
A
E
I
R
A
R
-
A
--
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
T
A
----
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
-
Q
F
S
G
A
V
G
N
Y
C
I
L
---
T
----
T
------
E
---
D
E
K
K
A
A
D
I
L
G
L
P
V
E
-
E
V
S
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
----------
P
H
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
--
D
C
Y
K
I
V
Q
Q
-
V
----
E
S
F
S
K
K
L
--------
Q
K
V
M
H
D
E
H
N
--
I
I
L
D
I
---
P
E
M
D
F
E
G
I
K
K
T
Y
-
L
K
----
E
I
D
H
V
F
D
R
-----
55
Fugue
74.18
38%
-95
- C3 -
4EEI
12
?
A:
[1-433]
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
E
D
-
R
M
-
V
P
K
G
T
A
A
E
I
R
A
R
-
A
--
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
T
A
----
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
-
F
Q
K
D
G
L
T
V
Q
F
S
G
A
V
G
N
Y
C
I
L
---
T
----
T
------
E
---
D
E
K
K
A
A
D
I
L
G
L
P
V
E
-
E
V
S
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
------------
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
--
D
C
Y
K
I
V
Q
Q
-
V
E
S
--
F
S
K
K
----------
L
Q
K
V
M
H
D
E
H
N
--
I
I
--
L
D
--
I
P
E
M
D
F
E
G
I
K
K
T
Y
L
K
----
E
I
D
H
V
F
D
R
S
V
K
A
R
39
HHSearch
74.11
28%
-109
- C3 -
2J91
5
PUR8_HUMAN
A:
[39-486]
L
A
S
R
Y
A
S
P
E
M
C
F
V
F
S
D
R
Y
K
F
R
T
W
R
Q
L
W
L
W
L
A
E
A
E
Q
T
L
G
L
P
I
T
D
E
Q
I
R
E
M
K
S
N
L
E
--
N
I
D
F
K
M
A
A
E
E
E
K
R
L
R
H
D
V
M
A
H
V
H
T
F
G
H
C
--
C
-
P
----
K
A
A
G
I
I
H
L
G
A
T
S
C
Y
V
G
D
N
T
D
L
I
I
L
R
N
A
L
D
L
L
L
P
K
L
A
R
V
I
S
R
L
A
D
F
A
K
E
R
A
S
L
P
T
L
G
F
T
H
F
Q
P
A
Q
L
T
T
V
G
K
R
C
C
L
W
I
Q
D
L
C
M
D
L
Q
N
L
K
R
-
V
R
D
D
L
R
F
R
G
V
K
G
T
T
G
T
Q
A
S
F
---
L
Q
L
F
E
G
D
D
H
K
V
E
Q
---
L
D
K
M
V
T
E
K
A
G
F
K
R
A
F
I
I
T
G
Q
T
Y
T
R
K
V
D
I
E
V
L
S
V
L
A
S
L
G
A
S
V
H
K
I
C
T
D
I
R
L
L
A
N
--
L
K
E
M
E
E
P
F
-----------
Y
K
R
N
P
M
R
S
E
R
C
C
S
L
A
R
H
L
M
T
L
V
M
D
P
L
Q
T
A
S
V
Q
W
F
E
R
T
L
D
D
S
A
N
R
R
I
C
L
A
E
A
F
L
T
A
D
T
I
L
N
T
L
Q
N
I
S
E
G
L
V
V
Y
P
K
V
I
E
R
R
I
R
Q
E
L
P
F
M
A
T
E
N
I
I
M
A
M
V
--
G
G
S
R
Q
--
D
C
H
E
K
I
R
V
-
L
S
Q
--
Q
A
A
S
V
V
K
QEGGDN
D
L
I
E
R
I
Q
V
D
------
A
Y
F
S
PI
H
S
Q
L
D
H
L
L
D
P
S
S
F
T
G
R
A
S
Q
Q
V
Q
R
F
L
E
E
E
----
35
HHSearch
73.57
29%
-104
- C3 -
1RE5
2
?
A:
[6-445]
F
D
A
Y
F
T
A
P
A
M
R
E
I
F
S
D
R
G
R
L
Q
G
M
L
D
F
E
A
A
L
A
R
A
E
A
S
A
G
L
-
V
P
H
S
A
V
A
A
I
E
A
A
C
Q
AE
R
Y
D
T
G
A
L
A
N
A
I
A
T
A
G
N
S
A
I
P
L
V
K
A
L
G
K
V
--
I
-
A
T
GVP
E
A
E
R
Y
V
H
L
G
A
T
S
Q
D
A
M
D
T
G
L
V
L
Q
L
R
D
A
L
D
L
I
E
A
D
L
G
K
L
A
D
T
L
S
Q
Q
A
L
K
H
A
D
T
P
L
V
G
R
T
W
L
Q
H
A
T
P
V
T
L
G
M
K
L
A
G
V
L
G
A
L
T
R
H
R
Q
R
L
Q
E
-
L
R
P
R
L
L
V
L
Q
F
G
G
A
S
G
S
L
A
A
L
GSK
A
----
M
------
P
---
V
A
E
A
L
A
E
Q
L
K
L
T
L
P
-
E
-
Q
P
W
H
T
Q
R
D
R
L
V
E
F
A
S
V
L
G
L
V
A
G
S
L
G
K
F
G
R
D
I
S
L
L
M
Q
T
E
A
G
E
V
F
E
P
S
A
P
----------
K
R
N
P
V
G
A
A
V
L
I
G
A
A
T
R
V
P
G
L
L
S
T
L
F
A
A
M
-
P
Q
E
H
E
R
S
L
G
L
W
H
A
E
W
E
T
L
P
D
I
C
C
L
V
S
G
A
L
R
Q
A
Q
V
I
A
E
G
M
E
V
D
A
A
R
M
R
R
N
L
D
L
T
Q
G
L
V
L
A
E
A
V
S
I
V
L
A
-
Q
R
L
G
R
D
--
R
A
H
H
L
L
E
Q
-
C
C
Q
--
R
A
V
A
E
Q
R
------
H
L
R
A
V
L
G
D
E
P
Q
--
V
S
A
E
L
S
--
G
E
E
L
D
R
L
L
D
P
A
H
Y
L
G
Q
A
R
V
W
V
A
R
A
V
S
E
H
----
38
HHSearch
72.45
39%
-95
- C3 -
4EEI
12
?
A:
[1-433]
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
E
D
-
R
M
-
V
P
K
G
T
A
A
E
I
R
A
R
-
A
--
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
-
T
A---
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
-
F
Q
K
D
G
L
T
V
Q
F
S
G
A
V
G
N
Y
C
I
L
---
T
----
T
------
E
---
D
E
K
K
A
A
D
I
L
G
L
P
V
E
-
E
V
S
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
------------
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
-
Y
L
S
S
F
Y
L
H
F
L
V
A
-
N
T
P
F
M
R
E
D
C
Y
K
I
V
Q
Q
-
V
----------
E
------
S
F
S
K
K
L
Q
K
V
M
H
D
E
H
N
I
I
L
D
--
I
P
E
M
D
F
E
G
I
K
K
T
Y
L
K
E
I
D
H
V
F
D
R
S
V
K
A
R
----
8
PsiBlast_PDB
72.20
34%
-105
- C3 -
1DOF
-
?
A:
[9-395]
---
R
Y
G
S
E
E
I
R
R
L
F
T
N
E
A
I
I
N
A
Y
L
E
V
E
R
A
L
V
C
A
L
E
E
L
G
V
-
A
E
R
G
C
C
E
K
V
-
N
K
-
A
--
S
V
S
A
D
E
V
--------
H
D
I
L
S
L
V
L
L
L
E
Q
K
--
S
-
G
------
C
R
Y
V
H
Y
G
A
T
S
N
D
I
I
D
T
A
W
A
L
L
I
R
R
A
L
A
A
V
K
E
K
A
R
A
V
G
D
Q
L
A
S
M
A
R
K
Y
K
T
L
E
M
V
G
R
T
H
G
Q
W
A
E
P
I
T
L
G
F
K
F
A
N
Y
Y
Y
E
L
Y
I
A
C
R
Q
L
A
L
-
A
E
E
F
I
R
-
A
K
I
G
G
A
V
G
T
M
A
S
W
---
G
----
E
------
L
G
L
E
V
R
R
R
V
A
E
R
L
G
L
P
H
H
-
V
I
T
T
Q
V
A
P
R
E
S
F
A
V
L
A
S
A
L
A
L
M
A
A
V
F
E
R
L
A
V
E
I
R
E
L
S
R
P
E
I
G
E
V
----
V
E
G
G
---------
A
N
P
T
A
S
E
R
I
V
S
L
A
R
Y
V
R
A
L
T
H
V
A
F
E
N
V
-
A
L
W
H
E
R
D
L
T
N
S
A
N
E
R
V
W
I
P
E
A
L
L
A
L
D
E
I
L
T
S
A
L
R
V
L
K
N
V
Y
I
D
E
E
R
I
T
E
N
L
Q
K
A
L
P
Y
I
L
T
E
F
H
M
N
R
M
I
K
E
G
A
S
R
A
--
E
A
Y
K
K
A
K
E
V
K
A
L
--
T
F
E
Y
Q
K
W
------
P
V
E
R
L
I
E
----------------------------------------------