@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06480: (2016-06-10 )
MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEIGIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNHPSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKTGRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEIIDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYREFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLRIRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPEKPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTAHITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLDAIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVKKEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKSKA
Atome Classification :
(20 SA)
.........10........20........30.---.......40........50.......--------.60.--------...------------..----..70-----........--.80.....-------..------------------.----90.-----------.......100----........110...---....120--...--....130.......140...-----------------....150.--------...---------...160.......170.....----..-----------180-------.......190.......200.......210.......220.......230..--.......240..-----.....250--...---..---...260.......270.......280.......290.......300....--------..----------------.310..--..----.-------------..320.......330.......340--.......350.......--360--.......370...---....380.......390-...-....400.......410.......420.--......430----.......440--------.----.-.....450-.-......460.......470.......480.......490....-.-..500..----...-..510.......520..-.....530.......540----.....--------...550..---.....560.......570.......580.--..-..-..590.......600.......-610........620.......630--.........640.......650.......660----.---------...-...670.......680.......690-----..--....-.700.......710.......720.......730.......740
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLLLEP
S
K
E
Q
I
K
E
E
K
L
Y
Q
QMGVS
D
D
E
F
A
L
I
E
---
S
I
L
GRLPN
Y
T
EI
G
I
F
S
V
M
W
S
EHCSYK--------NSK
P
--------
I
L
R
------------KF----PTS------G
E
R
VLQGP--GEGA
G
I
V
D
-------IG------------------D----N
Q
A
-----------
V
V
F
K
I
ESHN-----HPSALEPYQGAAT
G
---
V
G
G
I
I
R
D
--
V
F
S
--MGA
R
P
I
A
V
L
N
SLRFGELT
S
P
-----------------
R
V
K
Y
L
F
E
E
--------
V
V
A
---------
G
I
AGYGNCIGIPTVG
G
E
V
Q
FD----SS-----------YEG-------N
P
L
V
N
A
M
C
V
GLI
N
H
E
D
I
KKGQAKGVGN
T
V
M
Y
V
GAKTGRDGIHGATF
A
S
--
E
E--MSD
S
S
E
E
K
R
S
AV-----QVG
D
P
F
M
---
E
K
L
---
L
L
---
E
A
C
L
E
V
I
QCDALVG
I
Q
DMGAAGLTS
S
S
A
E
M
A
S
KAGS
G
I
E
M
N
L
D
L
IPQRET--------G
M
----------------
T
A
Y
E
M
M
--
L
S
----E-------------SQ
E
R
M
L
L
V
I
ERGRE
Q
E
I
I
D
I
F
D
KYD--
L
E
A
V
S
VGHVTDD
K
M
L
R
L
--THK--
G
E
V
V
C
EL
P
V
D
A
L
A---EEAPVYHKPSQE
P
A
Y
Y
R
-
E
F
L
-ETDVPAPQIE
D
A
N
E
M
L
K
A
L
L
QQPTIASK--E
W
V
YDQY
D
Y
----
M
V
R
T
N
T
V
VAP--------G----S-DA
G
V
L
R
IR-G-T
K
K
A
L
A
M
TTDC
N
A
R
Y
L
Y
LDPEVG
G
K
I
A
V
A
E
A
A
R
N
I
ICSGAE
P
L
-
A
-
V
TDNLNF----GNP-EK
P
E
I
F
W
Q
I
E
K
AAD
G
I
S
-
E
A
C
N
V
LSTPVIGG
N
V
S
L
-----
Y
NESN--------G
T
A
I
YPTP---
V
I
G
M
V
G
LIED
T
A
H
I
T
T
Q
H
F
K
QAG
D
L
V
Y
V
I--GE-TK-PEFA
G
S
E
L
Q
K
M
TEG
R
I
YGKAP
Q
-
I
-
D
L
D
V
E
L
S
R
Q
K
A
L
L
D
A
I
K
K
G
F
----
V
Q
SAHDVSEGGL
G
V
A
I
A
E
S
V
M
T
TENLG
A
N
V
T
V----E---------G
E
A
-
A
L
L
F
SESQ
S
R
F
V
V
S
V
K
K
E
H
Q
A
A
F
E
A
T
-----
V
K
--D
A
V
H
-
I
GEVTAD
G
I
L
A
I
QNQD
G
Q
Q
M
I
H
A
Q
T
K
E
L
E
R
V
W
K
G
A
I
P
C
L
LKSKA
21
HHSearch
81.41
47%
-74
- C3 -
3VIU
4
PURL_THET8
A:
[6-725]
------------------
K
E
I
G
I
P
E
G
E
Y
R
E
I
V
---
Q
R
L
G
R
E
P
N
R
V
E
L
L
L
F
K
V
M
W
S
E
H
C
A
Y
K
--------
N
S
R
P
--------
L
L
K
------------
A
L
----
P
K
E
------
G
E
A
V
L
Q
G
P
--
G
E
N
A
G
V
V
R
-------
V
G
------------------
E
----
G
W
A
-----------
V
A
F
K
I
E
S
H
N
-----
H
P
S
A
V
E
P
F
Q
G
A
A
T
G
---
V
G
G
I
L
R
D
--
I
M
S
--
M
G
A
R
P
I
A
L
L
D
S
L
R
F
G
P
P
E
E
A
-----------------
R
S
R
Y
L
L
K
G
--------
V
V
S
---------
G
I
A
F
Y
G
N
A
I
G
V
P
T
V
G
G
D
L
Y
F
H
----
E
G
-----------
Y
R
E
-------
N
P
L
V
N
A
M
C
L
G
L
L
R
E
E
-
H
L
K
R
S
R
A
S
L
G
R
P
I
Y
Y
A
G
A
K
T
G
R
D
G
I
-------------------------------
V
G
D
P
F
L
---
G
K
L
---
L
M
---
E
A
T
L
E
A
I
E
L
D
L
V
E
G
V
Q
D
M
G
A
A
G
L
T
S
S
L
S
E
L
A
H
K
S
G
L
G
V
E
L
H
L
D
L
V
P
T
R
E
E
--------
G
M
----------------
T
P
E
E
L
L
--
L
S
----
E
-------------
S
Q
E
R
M
V
L
V
P
K
E
G
K
E
K
A
L
E
E
V
F
G
R
W
G
--
L
D
C
V
P
V
A
R
T
I
P
E
R
V
F
R
V
--
L
F
R
--
G
E
V
V
A
E
V
P
T
E
A
L
A
----
E
A
P
T
Y
V
R
V
G
R
E
D
P
E
V
R
-
R
L
R
-
E
T
-
P
I
P
P
L
E
A
D
P
Q
E
V
L
R
R
L
L
A
S
P
N
L
A
S
R
--
E
A
V
Y
E
R
Y
D
H
----
Q
V
G
T
R
T
A
L
L
P
--------
G
K---
G
-
D
A
A
V
L
W
I
K
-
G
-
T
R
L
G
V
A
A
K
V
D
Q
N
P
R
Y
S
R
L
H
P
R
L
G
A
M
H
A
L
A
E
A
C
R
N
V
S
V
V
G
A
K
P
L
-
A
-
Y
T
D
G
L
N
L
----
G
S
P
-
E
T
P
E
G
Y
H
E
L
A
E
T
I
A
G
L
K
-
E
A
S
E
A
L
G
V
P
V
V
S
G
N
V
S
L
-----
Y
N
E
S
G
--------
G
K
R
I
P
P
T
A
---
M
V
G
V
V
G
V
L
E
V
-
D
K
R
A
E
M
G
F
R
R
P
G
E
V
L
L
L
I
--
G
E
-
E
R
-
G
E
L
G
A
S
E
V
L
Y
L
L
T
G
K
E
F
G
H
P
P
R
-
L
-
D
L
G
R
E
K
A
V
Q
E
A
I
R
D
L
I
Q
R
G
L
----
T
R
T
A
H
D
V
A
E
G
G
L
L
L
A
L
A
E
M
T
F
P
Y
-
G
V
G
A
T
V
E
V
----
R
E--------
E
G
L
-
E
A
L
F
G
E
A
P
S
R
V
L
F
T
V
E
K
T
R
L
Q
E
A
T
L
L
L
E
E
R
-
G
L
--
P
Y
R
V
-
L
G
E
T
G
G
K
S
-
L
T
V
L
-
T
P
G
-
G
V
L
E
W
S
L
E
E
L
L
S
A
W
K
A
P
L
R
E
V
L
D
G
--
1
PsiBlast_PDB
77.25
48%
-70
- C3 -
3VIU
4
PURL_THET8
A:
[2-667]
--------------
E
A
L
A
K
E
I
G
I
P
E
G
E
Y
R
E
I
V
---
Q
R
L
G
R
E
P
N
R
V
E
L
L
L
F
K
V
M
W
S
E
H
C
A
Y
K
--------
N
S
R
P
--------
L
L
K
------------
A
L
----
P
K
E
------
G
E
A
V
L
Q
G
P
--
G
E
N
A
G
V
V
R
-------
V
G
------------------
E
----
G
W
A
-----------
V
A
F
K
I
E
S
H
N
-----
H
P
S
A
V
E
P
F
Q
G
A
A
T
G
---
V
G
G
I
L
R
D
--
I
M
S
--
M
G
A
R
P
I
A
L
L
D
S
L
R
F
G
P
P
E
E
A
-----------------
R
S
R
Y
L
L
K
G
--------
V
V
S
---------
G
I
A
F
Y
G
N
A
I
G
V
P
T
V
G
G
D
L
Y
F
H
----
E
G
-----------
Y
R
E
-------
N
P
L
V
N
A
M
C
L
G
L
L
R
E
E
H
L
K
R
S
R
A
S
-
L
G
R
P
I
Y
Y
A
G
A
K
T
G
R
D
G
I
-------------------------------
V
G
D
P
F
L
---
G
K
L
---
L
M
---
E
A
T
L
E
A
I
E
L
D
L
V
E
G
V
Q
D
M
G
A
A
G
L
T
S
S
L
S
E
L
A
H
K
S
G
L
G
V
E
L
H
L
D
L
V
P
T
R
E
E
--------
G
M
----------------
T
P
E
E
L
L
--
L
S
----
E
-------------
S
Q
E
R
M
V
L
V
P
K
E
G
K
E
K
A
L
E
E
V
F
G
R
W
G
--
L
D
C
V
P
V
A
R
T
I
P
E
R
V
F
R
V
--
L
F
R
--
G
E
V
V
A
E
V
P
T
E
A
L
A
----
E
A
P
T
Y
V
R
V
G
R
E
D
P
E
V
R
-
R
L
R
-
E
T
P
I
P
-
P
L
E
A
D
P
Q
E
V
L
R
R
L
L
A
S
P
N
L
A
S
R
--
E
A
V
Y
E
R
Y
D
H
----
Q
V
G
T
R
T
A
L
L
P
--------
G
----
K
G
D
A
A
V
L
W
I
K
-
G
-
T
R
L
G
V
A
A
K
V
D
Q
N
P
R
Y
S
R
L
H
P
R
L
G
A
M
H
A
L
A
E
A
C
R
N
V
S
V
V
G
A
K
P
L
-
A
-
Y
T
D
G
L
N
L
----
G
S
P
-
E
T
P
E
G
Y
H
E
L
A
E
T
I
A
G
L
K
-
E
A
S
E
A
L
G
V
P
V
V
S
G
N
V
S
L
-----
Y
N
E
S
G
--------
G
K
R
I
P
P
T
A
---
M
V
G
V
V
G
V
L
E
V
D
K
R
-
A
E
M
G
F
R
R
P
G
E
V
L
L
L
I
--
G
E
-
E
R
-
G
E
L
G
A
S
E
V
L
Y
L
L
T
G
K
E
F
G
H
P
P
R
-
L
-
D
L
G
R
E
K
A
V
Q
E
A
I
R
D
L
I
Q
R
G
L
----
T
R
T
A
H
D
V
A
E
G
G
L
L
L
A
L
A
E
M
T
F
P
Y
-
G
V
G
A
T
V
E
V
----
R
---------
E
E
G
L
E
A
L
F
G
E
A
P
S
R
V
L
F
T
V
E
K
-------------------------------------------------------------------
6
PsiBlast_PDB
65.20
40%
-96
- C3 -
2HRY
4
PURL_THEMA
A:
[8-500]
-----------------------------
I
L
K
---
E
K
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
------------
R
L
----
P
K
T
--------------------
G
V
V
N
-------
L
D
------------------
D
----
Y
Y
S
-----------
V
A
F
K
I
E
S
A
N
-----
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
---
V
G
G
I
I
R
D
--
V
L
A
--
M
G
A
R
P
T
A
I
F
D
S
L
H
M
S
R
I
-------------------------
I
D
G
--------
I
I
E
---------
G
I
A
D
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
----
S
L
-----------
Y
A
H
-------
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
-------------------------------
V
G
D
P
F
A
---
E
K
M
---
L
I
---
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
--------
D
M
----------------
E
P
W
E
I
L
--
I
S
----
E
-------------
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
--
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
--
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
N
AP
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
-
E
V
--------
N
A
R
E
------------------
V
F
E
Q
Y
D
H
----
M
V
G
T
D
T
V
V
P
P
--------
G
----
F
-
G
A
A
V
M
R
I
K
---
R
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
A
E
P
L
-
A
-
I
T
N
C
V
N
Y
----
G
D
P
-
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
K
-
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
---
V
V
G
M
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
65.19
40%
-95
- C3 -
2HS0
4
PURL_THEMA
A:
[8-500]
-----------------------------
I
L
K
---
E
K
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
------------
R
L
----
P
K
T
------
G
---
F
E
G
-----
N
A
G
V
V
N
-------
L
D
------------------
D
----
Y
Y
S
-----------
V
A
F
K
I
E
S
H
N
-----
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
---
V
G
G
I
I
R
D
--
V
L
A
--
M
G
A
R
P
T
A
I
F
D
S
L
H
M
S
R
I
-------------------------
I
D
G
--------
I
I
E
---------
G
I
A
D
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
----
S
L
-----------
Y
A
H
-------
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
------------------------
I
-----
Q
V
G
D
P
F
A
---
E
K
M
---
L
I
---
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
--------
D
M
----------------
E
P
W
E
I
L
--
I
S
----
E
-------------
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
--
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
--
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
-
E
V
--------
N
A
R
E
------------------
V
F
E
Q
Y
D
-------
G
T
D
T
V
V
P
P
--------
G
----
F
-
G
A
A
V
M
R
I
K
---
R
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
A
E
P
L
-
A
-
I
T
N
C
V
N
Y
----
G
D
P
-
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
K
-
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
---
V
V
G
M
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.89
40%
-84
- C3 -
2HS3
2
PURL_THEMA
A:
[8-500]
-----------------------------
I
L
K
---
E
K
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
------------
R
L
----
P
K
T
------
G
---
F
E
G
-----
N
A
G
V
V
N
-------
L
D
------------------
D
----
Y
Y
S
-----------
V
A
F
K
I
E
S
H
N
-----
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
---
V
G
G
I
I
R
D
--
V
L
A
--
M
G
A
R
P
T
A
I
F
D
S
L
H
M
S
R
I
-------------------------
I
D
G
--------
I
I
E
---------
G
I
A
D
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
----
S
L
-----------
Y
A
H
-------
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
H
G
A
S
F
A
S
--
E
D
--
L
T
G
D
K
A
T
K
L
S
-
I
-----
Q
V
G
D
P
F
A
---
E
K
M
---
L
I
---
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
--------
D
M
----------------
E
P
W
E
I
L
--
I
S
----
E
-------------
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
--
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
--
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
-
E
V
--------
N
A
R
E
------------------
V
F
E
Q
Y
D
H
----
M
V
G
T
D
T
V
V
P
P
--------
G
----
F
-
G
A
A
V
M
R
I
K
---
R
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
A
E
P
L
-
A
-
I
T
N
C
V
N
Y
----
G
D
P
-
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
K
-
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
---
V
V
G
M
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.53
24%
-65
- C3 -
4MGH
16
PUR4_SALTY
A:
[171-990]
---
L
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
------------
T
F
----
E
T
T
------
P
D
Y
V
L
S
A
Y
--
K
D
N
A
A
V
M
E
G
S
A
V
G
R
Y
F
A
------------------
D
----
H
N
T
G
R
Y
D
F
H
QEPA
H
I
L
M
K
V
E
T
H
N
-----
H
P
T
A
I
S
P
W
P
G
A
A
T
G
---
S
G
G
E
I
R
D
E
G
A
T
G
--
R
G
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
-----------------
G
F
E
Q
P
W
E
E
DFGKPERI
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
KV
N
S
-----------
H
N
G
E
E
L
R
G
YH
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
----------------------
F
A
S
V
-----
Q
R
D
N
P
E
M
---
E
R
R
C
Q
E
V
I
---
D
R
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
--------
G
M
----------------
S
P
L
E
I
W
--
C
N
----
E
-------------
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
--
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
---
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
-
D
A
L
N
R
A
D
I
---
T
I
A
D
A
---
V
K
R
V
L
H
L
P
T
V
A
E
K
--
T
F
L
V
T
I
G
D
R
TVTG
M
V
A
R
D
Q
M
V
G
P
--------
W
QVPV
A
-
D
C
A
V
T
T
A
S
L
D
-
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
-
K
R
I
K
L
S
A
N
W
M
AAA
G
H
P
-
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
--
E
-
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
DL
G
K
-
G
H
-
N
A
L
G
A
T
A
L
A
Q
V
Y
--
R
Q
L
G
D
K
P
A
-
D
-
V
R
D
V
--
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
RK
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
-
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
-
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
A
--
D
C
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
--
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
------------
14
PsiBlast_PDB
63.97
24%
-65
- C3 -
4LGY
17
PUR4_SALTY
A:
[173-992]
---
L
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
W
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
------------
T
F
----
E
T
T
------
P
D
Y
V
L
S
A
Y
--
K
D
N
A
A
V
M
E
G
S
A
V
G
R
Y
F
A
------------------
D
----
H
N
T
G
R
Y
D
F
H
Q
E
PA
H
I
L
M
K
V
E
T
H
N
-----
H
P
T
A
I
S
P
W
P
G
A
A
T
G
---
S
G
G
E
I
R
D
E
G
A
T
G
--
R
G
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
-----------------
G
F
E
Q
P
W
E
E
DFGKPERI
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
KV
N
S
-----------
H
N
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
--------------------
D
F
A
S
V
-----
Q
R
D
N
P
E
M
---
E
R
R
C
Q
E
V
I
---
D
R
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
--------
G
M
----------------
S
P
L
E
I
W
--
C
N
----
E
-------------
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
--
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
---
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
-
D
A
L
N
R
A
D
I
---
T
I
A
D
A
---
V
K
R
V
L
H
L
P
T
V
A
E
K
--
T
F
L
V
T
I
G
D
R
TVTG
M
V
A
R
D
Q
M
V
G
P
--------
W
QVPV
A
-
D
C
A
V
T
T
A
S
L
D
-
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
-
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
-
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
--
E
-
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
DL
G
K
-
G
H
-
N
A
L
G
A
T
A
L
A
Q
V
Y
--
R
Q
L
G
D
K
P
A
-
D
-
V
R
D
V
--
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
RK
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
-
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
-
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
A
--
D
C
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
--
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
------------
7
PsiBlast_PDB
63.97
24%
-65
- C3 -
1T3T
5
PUR4_SALTY
A:
[171-990]
---
L
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
------------
T
F
----
E
T
T
------
P
D
Y
V
L
S
A
Y
--
K
D
N
A
A
V
M
E
GSA
V
G
R
Y
F
A
------------------
D
----
H
N
T
G
R
Y
D
F
H
Q
E
PA
H
I
L
M
K
V
E
T
H
N
-----
H
P
T
A
I
S
P
W
P
G
A
A
T
G
---
S
G
G
E
I
R
D
E
G
A
T
G
--
R
G
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
-----------------
G
F
E
Q
P
W
E
E
DFGKPERI
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
KV
N
S
-----------
H
N
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
----------------------
F
A
S
V
-----
Q
R
D
N
P
E
M
---
E
R
R
C
Q
E
V
I
---
D
R
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
--------
G
M
----------------
S
P
L
E
I
W
--
C
N
----
E
-------------
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
--
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
---
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
-
D
A
L
N
R
A
D
I
---
T
I
A
D
A
---
V
K
R
V
L
H
L
P
T
V
A
E
K
--
T
F
L
V
T
I
G
D
R
TVTG
M
V
A
R
D
Q
M
V
G
P
--------
W
QVPV
A
-
D
C
A
V
T
T
A
S
L
D
-
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
-
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
-
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
--
E
-
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
DL
G
K
-
G
H
-
N
A
L
G
A
T
A
L
A
Q
V
Y
--
R
Q
L
G
D
K
P
A
-
D
-
V
R
D
V
--
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
RK
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
-
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
-
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
A
--
D
C
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
--
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
------------
5
PsiBlast_PDB
63.96
40%
-93
- C3 -
2HRU
4
PURL_THEMA
A:
[8-500]
-----------------------------
I
L
K
---
E
K
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
------------
R
L
----
P
K
T
------
G
---
F
E
G
-----
N
A
G
V
V
N
-------
L
D
------------------
D
----
Y
Y
S
-----------
V
A
F
K
I
E
S
A
N
-----
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
---
V
G
G
I
I
R
D
--
V
L
A
--
M
G
A
R
P
T
A
I
F
D
S
L
H
M
S
R
I
-------------------------
I
D
G
--------
I
I
E
---------
G
I
A
D
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
----
S
L
-----------
Y
A
H
-------
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
-------------------------------
V
G
D
P
F
A
---
E
K
M
---
L
I
---
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
--------
D
M
----------------
E
P
W
E
I
L
--
I
S
----
E
-------------
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
--
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
--
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
-
E
V
--------
N
A
R
E
------------------
V
F
E
Q
Y
D
H
----
M
V
G
T
D
T
V
V
P
P
--------
G
----
F
-
G
A
A
V
M
R
I
K
---
R
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
A
E
P
L
-
A
-
I
T
N
C
V
N
Y
----
G
D
P
-
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
K
-
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
---
V
V
G
M
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.71
24%
-67
- C3 -
4R7G
6
PUR4_SALTY
A:
[171-990]
---
L
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
------------
T
F
----
E
T
T
------
P
D
Y
V
L
S
A
Y
--
K
D
N
A
A
V
M
E
G
S
A
V
G
R
Y
F
A
------------------
D
----
H
N
T
G
R
Y
D
F
H
QEPA
H
I
L
M
K
V
E
T
H
N
-----
H
P
T
A
I
S
P
W
P
G
A
A
T
G
---
S
G
G
E
I
R
D
E
G
A
T
G
--
R
G
A
K
P
K
A
G
L
I
G
F
S
V
S
N
L
R
I
P
-----------------
G
F
E
Q
P
W
E
E
DFGKPERI
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
KV
N
S
-----------
H
N
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
----------------------
F
A
S
V
-----
Q
R
D
N
P
E
M
---
E
R
R
C
Q
E
V
I
---
D
R
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
--------
G
M
----------------
S
P
L
E
I
W
--
C
N
----
E
-------------
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
--
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
---
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
-
D
A
L
N
R
A
D
I
---
T
I
A
D
A
---
V
K
R
V
L
H
L
P
T
V
A
E
K
--
T
F
L
V
T
I
G
D
R
TVTG
M
V
A
R
D
Q
M
V
G
P
--------
W
QVPV
A
-
D
C
A
V
T
T
A
S
L
D
-
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
-
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
-
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
--
E
-
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
DL
G
K
-
G
H
-
N
A
L
G
A
T
A
L
A
Q
V
Y
--
R
Q
L
G
D
K
P
A
-
D
-
V
R
D
V
--
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
RK
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
-
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
-
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
A
--
D
C
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
--
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
------------
11
PsiBlast_PDB
63.65
24%
-67
- C3 -
3UGJ
8
PUR4_SALTY
A:
[171-992]
---
L
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
------------
T
F
----
E
T
T
------
P
D
Y
V
L
S
A
Y
--
K
D
N
A
A
V
M
E
G
S
AVGR
Y
F
A
------------------
D
----
H
N
T
G
R
Y
D
F
H
QEPA
H
I
L
M
K
V
E
T
H
N
-----
H
P
T
A
I
S
P
W
P
G
A
A
T
G
---
S
G
G
E
I
R
D
E
G
A
T
G
--
R
G
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
-----------------
G
F
E
Q
P
W
E
E
DFGKPERI
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
KV
N
S
-----------
H
N
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
--------------------
D
F
A
S
V
-----
Q
R
D
N
P
E
M
---
E
R
R
C
Q
E
V
I
---
D
R
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
--------
G
M
----------------
S
P
L
E
I
W
--
C
N
----
E
-------------
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
--
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
---
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
-
D
A
L
N
R
A
D
I
---
T
I
A
D
A
---
V
K
R
V
L
H
L
P
T
V
A
E
K
--
T
F
L
V
T
I
G
D
R
TVTG
M
V
A
R
D
Q
M
V
G
P
--------
W
QVPV
A
-
D
C
A
V
T
T
A
S
L
D
-
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
-
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
-
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
--
E
-
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
----------
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
DL
G
K
-
G
H
-
N
A
L
G
A
T
A
L
A
Q
V
Y
--
R
Q
L
G
D
K
P
A
-
D
-
V
R
D
V
--
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
RK
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
-
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
-
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
A
--
D
C
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
--
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
------------
12
PsiBlast_PDB
63.43
24%
-66
- C3 -
4L78
17
PUR4_SALTY
A:
[171-990]
---
L
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
------------
T
F
----
E
T
T
------
P
D
Y
V
L
S
A
Y
--
K
D
N
A
A
V
M
E
G
S
AVGR
Y
F
A
------------------
D
----
H
N
T
G
R
Y
D
F
H
Q
E
PA
H
I
L
M
K
V
E
T
H
N
-----
H
P
T
A
I
S
P
W
P
G
A
A
T
G
---
S
G
G
E
I
R
D
E
G
A
T
G
--
R
G
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
-----------------
G
F
E
Q
P
W
E
E
DFGKPERI
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
KV
N
S
-----------
H
N
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
---------------------
D
F
A
S
V
-----
Q
R
D
N
P
E
M
---
E
R
R
C
Q
E
V
I
---
D
R
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
--------
G
M
----------------
S
P
L
E
I
W
--
C
N
----
E
-------------
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
--
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
---
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
-
D
A
L
N
R
A
D
I
---
T
I
A
D
A
---
V
K
R
V
L
H
L
P
T
V
A
E
K
--
T
F
L
V
T
I
G
D
R
TVTG
M
V
A
R
D
Q
M
V
G
P
--------
W
QVPV
A
-
D
C
A
V
T
T
A
S
L
D
-
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
-
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
-
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
--
E
-
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
DL
G
K
-
G
H
-
N
A
L
G
A
T
A
L
A
Q
V
Y
--
R
Q
L
G
D
K
P
A
-
D
-
V
R
D
V
--
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
RK
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
-
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
-
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
A
--
D
C
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
--
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
------------
22
HHSearch
63.38
23%
-64
- C3 -
4LGY
17
PUR4_SALTY
A:
[174-1001]
----
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
W
A
Q
A
N
S
E
H
C
R
H
K
--------
I
F
N
A
--------
D
W
I
I
DGKPQPKS
L
F
K
M
I
K
N
T
F
E
T
T
------
P
D
Y
V
L
S
A
Y
--
K
D
N
A
A
V
M
E
-------
G
S
A
V
G
R
Y
F
A
D
HNTG
R
Y
D
F
H
Q
E
----
P
A
H
-----------
I
L
M
K
V
E
T
H
N
-----
H
P
T
A
I
S
P
W
P
G
A
A
T
G
---
S
G
G
E
I
R
D
--
E
G
A
TG
R
G
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
GFEQPWEEDFGKPERIV
T
A
L
D
I
M
T
E
--------
G
P
L
---------
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
----
E
E
KVNSHN
G
E
E
L
R
G
Y
H
-------
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
-
Q
K
G
E
I
V
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
--------------------
D
F
A
S
V
-----
Q
R
D
N
P
E
M
---
E
R
R
---
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
--------
G
M
----------------
S
P
L
E
I
W
--
C
N
----
E
-------------
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
--
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
--
H
D
N
HF
D
N
Q
P
I
D
L
P
L
D
V
L
L
---
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
-
D
A
------
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
--
T
F
L
V
T
I
G
D
R
----
T
V
T
G
M
V
A
R
D
Q
MVGPWQVP
V
----
A
-
D
C
A
V
T
T
A
S
-
L
D
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
K
R
-
I
K
L
S
A
N
W
----
M
A
A
A
G
H
P
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
E
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
-----
S
M
K
T
R
W
Q
EGN
E
Q
R
E
M
T
S
P
L
S
L
---
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
DL
G
K
-
G
H
-
N
A
L
G
A
T
A
L
A
Q
V
Y
-
R
Q
L
G
D
K
P
A
D
-
V
R
D
V
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
R
K
----
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
-
H
C
G
V
Q
V
D
I
----
A
ALGD-----
D
H
L
-
A
A
L
F
N
E
E
-
L
G
G
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
-
G
L
AD
C
V
H
Y
-
L
G
Q
A
L
A
G
D
R
F
V
I
T
-
A
N
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
W
A
E
T
T
W
Q
M
Q
----
4
PsiBlast_PDB
62.96
40%
-85
- C3 -
2HS4
6
PURL_THEMA
A:
[8-500]
-----------------------------
I
L
K
---
E
K
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
--------
H
T
K
K
--------
Y
I
R
------------
R
L
----
P
K
T
------
G
---
F
E
G
-----
N
A
G
V
V
N
-------
L
D
------------------
D
----
Y
Y
S
-----------
V
A
F
K
I
E
S
H
N
-----
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
---
V
G
G
I
I
R
D
--
V
L
A
--
M
G
A
R
P
T
A
I
F
D
S
L
H
M
S
R
I
-------------------------
I
D
G
--------
I
I
E
---------
G
I
A
D
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
----
S
L
-----------
Y
A
H
-------
N
P
L
V
N
V
L
A
A
G
V
V
R
N
D
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
H
G
A
S
F
A
S
--
E
D
--
L
T
G
D
K
A
T
K
L
S
-
I
-----
Q
V
G
D
P
F
A
---
E
K
M
---
L
I
---
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
--------
D
M
----------------
E
P
W
E
I
L
--
I
S
----
E
-------------
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
--
L
F
G
D
V
V
A
E
V
I
E
E
P
V
Y
R
V
--
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
-
E
V
--------
N
A
R
E
------------------
V
F
E
Q
Y
D
H
----
M
V
G
T
D
T
V
V
P
P
--------
G
----
F
-
G
A
A
V
M
R
I
K
---
R
D
G
G
Y
S
L
V
T
H
S
R
A
D
L
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
A
E
P
L
-
A
-
I
T
N
C
V
N
Y
----
G
D
P
-
D
V
D
P
V
--
G
L
S
A
M
M
T
A
L
K
-
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
-----
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
---
V
V
G
M
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.90
24%
-66
- C3 -
3UJN
5
PUR4_SALTY
A:
[171-990]
---
L
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
------------
T
F
----
E
T
T
------
P
D
Y
V
L
S
A
Y
--
K
D
N
A
A
V
M
E
G
S
A
V
G
R
Y
F
A
------------------
D
----
H
N
T
G
R
Y
D
F
H
Q
E
P
A
H
I
L
M
K
V
E
T
H
N
-----
H
P
T
A
I
S
P
W
P
G
A
A
T
G
---
S
G
G
E
I
R
D
E
G
A
T
G
--
R
G
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
-----------------
G
F
E
Q
P
W
E
E
DFGKPERI
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
KV
N
S
-----------
H
N
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
--------------------
D
F
A
S
V
-----
Q
R
D
N
P
E
M
---
E
R
R
C
Q
E
V
I
---
D
R
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
--------
G
M
----------------
S
P
L
E
I
W
--
C
N
----
E
-------------
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
--
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
---
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
-
D
A
L
N
R
A
D
I
---
T
I
A
D
A
---
V
K
R
V
L
H
L
P
T
V
A
E
K
--
T
F
L
V
T
I
G
D
R
TVTG
M
V
A
R
D
Q
M
V
G
P
--------
W
QVPV
A
-
D
C
A
V
T
T
A
S
L
D
-
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
-
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
-
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
--
E
-
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
DL
G
K
-
G
H
-
N
A
L
G
A
T
A
L
A
Q
V
Y
--
R
Q
L
G
D
K
P
A
-
D
-
V
R
D
V
--
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
RK
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
-
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
-
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
A
--
D
C
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
--
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
------------
9
PsiBlast_PDB
62.41
24%
-66
- C3 -
3UMM
6
PUR4_SALTY
A:
[171-990]
---
L
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
IFN
A
D
W
I
I
D
G
K
P
QPKS
L
F
K
M
I
K
N
------------
T
F
----
E
T
T
------
P
D
Y
V
L
S
A
Y
--
K
D
N
A
A
V
M
E
GSA
V
G
R
Y
F
A
------------------
D
----
H
N
T
G
R
Y
D
F
H
Q
E
P
A
H
I
L
M
K
V
E
T
H
N
-----
H
P
T
A
I
S
P
W
P
G
A
A
T
G
---
S
G
G
E
I
R
D
E
G
A
T
G
--
R
G
A
K
P
K
A
G
L
V
G
F
S
V
S
N
L
R
I
P
-----------------
G
F
E
Q
P
W
E
E
DFGKPERI
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
A
L
T
G
Y
F
R
T
Y
E
E
KV
N
S
-----------
H
N
G
E
E
L
R
G
Y
H
K
P
I
M
L
A
G
G
I
G
N
I
R
A
D
H
V
Q
K
G
E
I
V
-
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
---------------------
D
F
A
S
V
-----
Q
R
D
N
P
E
M
---
E
R
R
C
Q
E
V
I
---
D
R
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
--------
G
M
----------------
S
P
L
E
I
W
--
C
N
----
E
-------------
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
--
A
P
Y
A
V
I
G
D
A
T
E
E
Q
H
L
S
L
H
D
N
H
F
--
D
N
Q
P
I
D
L
P
L
D
V
L
L
---
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
A
K
G
-
D
A
L
N
R
A
D
I
---
T
I
A
D
A
---
V
K
R
V
L
H
L
P
T
V
A
E
K
--
T
F
L
V
T
I
G
D
R
TVTG
M
V
A
R
D
Q
M
V
G
P
--------
W
QVPV
A
-
D
C
A
V
T
T
A
S
L
D
-
S
Y
Y
G
E
A
M
S
I
G
E
R
A
P
V
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
-
K
R
I
K
L
S
A
N
W
M
A
AA
G
H
P
-
G
E
D
A
G
L
Y
D
A
V
K
A
V
G
--
E
-
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
SM
K
T
R
W
Q
E
G
N
--------
E
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
E
D
N
A
L
L
L
I
DL
G
K
-
G
H
-
N
A
L
G
A
T
A
L
A
Q
V
Y
--
R
Q
L
G
D
K
P
A
-
D
-
V
R
D
V
--
A
Q
L
K
G
F
Y
D
A
M
Q
A
L
V
A
A
RK
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
-
H
C
G
V
Q
V
D
I
AALG
D
---------
D
H
L
-
A
A
L
F
N
E
E
L
G
G
-
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
Y
G
L
A
--
D
C
V
H
Y
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
D
--
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
------------
27
HHSearch
43.05
22%
-90
- C3 -
3VIU
3
PURL_THET8
A:
[26-360]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
R
V
E
L
L
L
F
K
V
M
W
S
E
H
C
A
Y
K
NS
R
P
L
L
K
A
L
P
K
----
E
G
-
E
A
V
L
Q
G
P
--------
G
----
E
-
N
A
G
V
V
R
V
G
-
E
--
G
W
A
V
A
F
K
I
E
S
H
N
H
P
S
A
V
E
P
F
Q
G
A
A
T
G
V
G
G
I
L
R
D
I
M
S
M
G
A
R
P
I
-
A
-
L
L
D
S
L
R
F
----
G
P
P
-
E
E
A
R
S
R
Y
L
L
K
G
V
V
S
G
I
A
-
F
Y
G
N
A
I
G
V
P
T
V
G
G
D
L
Y
F
-----
H
E
G
Y
R
-----------
E
N
P
L
V
---
N
A
M
C
L
G
L
L
R
E
-
E
-
H
L
K
R
S
R
A
S
L
G
R
P
I
Y
Y
A
--
G
A
K
T
G
R
D
G
I
-------------------V
G
-
D
P
F
L
G
K
L
L
M
E
A
T
L
E
A
I
E
L
D
L
----
V
E
G
V
Q
D
M
G
A
A
G
L
T
S
S
L
S
E
L
A
H
K
S
-
G
L
G
V
E
L
H
L
----
D
LVPTREEGM
T
P
E
-
E
L
L
L
S
E
S
Q
E
R
M
V
L
V
P
K
E
G
K
E
K
A
L
E
E
V
F
G
R
W
-
G
L
--
D
C
V
P
-
V
A
R
T
I
P
E
R
V
F
R
V
L
-
F
R
G
E
V
V
A
E
V
P
T
E
A
L
----------------
36
HHSearch
41.21
15%
-126
- C3 -
2Z01
-
PUR5_GEOKA
A:
[32-342]
----------------------------------------------------------------------------------------------------------------
P
E
V
L
G
-------
G
G
L
F
D
-------
L
S
------------------
A
LGYR
Q
P
V
-----------
L
I
S
G
T
D
G
V
G
T
K
L
K
L
A
F
L
L
D
R
H
D
T
I
G
I
D
C
---
V
A
M
C
V
N
D
--
I
I
V
--
Q
G
A
E
P
L
F
F
L
D
Y
I
A
C
G
K
A
V
---------------------
P
E
K
I
A
A
--------
I
V
K
---------
G
V
A
D
G
C
V
E
A
G
C
A
L
I
G
G
E
T
A
E
----------------------------
E
Y
D
L
A
G
F
A
V
G
V
A
E
K
E
R
L
I
T
G
E
T
I
Q
A
G
D
A
L
V
G
L
----
P
S
S
G
L
H
S
N
G
Y
S
L
--
V
R
R
I
V
F
E
Q
A
K
L
S
L
D
E
I
YEPLD
V
P
L
G
E
E
L
L
KP
T
R
I
---
Y
A
---
K
L
L
R
S
V
R
E
R
F
T
I
K
G
M
A
H
I
T
G
G
G
L
I
E
N
I
P
R
M
L
P
P
-
G
I
G
A
R
I
Q
L
G
S
W
P
I
L
P
I
F
D
F
L
R
E
K
G
S
L
----------------
E
E
E
E
M
F
S
V
F
N
----
M
-------------
G
-
I
G
L
V
L
A
V
S
P
E
T
A
A
P
L
V
E
W
L
S
E
R
G
--
E
P
A
Y
I
I
G
E
V
A
K
G
A
G
V
S
F
--
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
37.48
20%
-89
- C3 -
3U0O
1
SELD_ECOLI
A:
[29-338]
-------------------------------------------------------------------------------------------------
I
----
L
H
S
EQA
K
F
V
D
P
N
L
L
V
G
N
ET
R
D
D
A
A
V
Y
D
-------
L
G
------------------
N
----
G
T
S
-----------
V
I
S
T
T
D
F
-
F
-----
M
P
I
V
D
N
P
F
D
F
G
R
I
A
---
A
T
N
A
I
S
D
--
I
F
A
--
M
G
G
K
P
I
M
A
I
A
I
L
G
W
P
I
N
K
-------------------
L
S
P
E
I
A
R
E
--------
V
T
E
---------
G
G
R
Y
A
C
R
Q
A
G
I
A
L
A
G
G
H
S
I
D
A
----
P
----------------------
E
P
I
F
G
L
A
V
T
G
I
V
P
T
E
R
V
K
K
N
S
T
A
Q
A
G
C
K
L
F
L
----
T
K
P
L
G
I
G
V
L
T
T
A
E
--
K
-----
K
S
L
-
L
K
P
E
H
Q
-----
G
L
A
T
E
V
M
---
C
R
----
M
N
---
I
A
G
A
S
F
A
N
I
E
G
V
K
A
M
T
D
V
T
G
F
G
L
L
G
H
L
S
E
M
C
Q
G
A
G
V
Q
A
R
V
D
Y
E
A
I
P
K
L
P
G
--------
V
E
E
Y
I
KLGAVP
G
G
T
E
R
N
F
A
S
Y
G
H
L
--
M
G
----
E
MP
R
E
V
R
D
L
L
C
DPQ
T
S
G
G
L
L
L
A
V
M
P
E
A
E
N
E
V
K
A
T
A
A
E
F
G
--
I
E
L
T
A
I
G
E
L
V
P
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
36.93
24%
-88
- C3 -
3WJQ
16
?
A:
[51-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
H
-----------
I
V
F
T
I
D
G
H
T
-----
V
K
P
L
F
F
P
--
G
G
D
I
G
R
L
A
V
S
G
T
V
N
D
--
L
A
V
--
M
G
A
E
P
I
A
L
A
N
S
M
I
I
G
E
G
L
D
M
-----------------
E
V
---
L
K
R
--------
V
L
K
---------
S
M
D
E
T
A
R
E
V
P
V
P
I
V
T
G
D
T
K
V
V
----
E
D
-----------
K
I
E
-------
M
F
V
I
T
A
-
G
I
G
I
A
E
H
P
-
V
S
D
A
G
A
K
-
V
G
D
A
V
L
V
----
S
G
T
I
G
D
H
G
I
A
L
M
S
H
R
E
G
--
I
A
F
E
T
E
L
K
S
D
V
A
-----
P
I
W
D
------------
V
V
---
K
A
V
A
E
T
I
G
W
E
N
I
H
A
M
K
D
P
T
R
A
G
L
S
N
A
L
N
E
I
A
R
K
S
N
V
G
I
L
V
R
E
A
D
I
P
I
R
P
E
--------
V
R
----------------
A
A
S
E
M
L
G-
I
S
PYD
V
A
-------------
N
E
G
K
V
V
M
V
V
A
R
E
Y
A
E
E
A
L
E
A
M
R
K
T
E
KG
R
N
A
A
I
I
G
E
V
I
A
D
--------
Y
R
--
G
K
V
L
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------