@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06520: (2016-06-10 )
MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENGVDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVNLYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKEEGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGENPHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHMNPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSFSQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTKREPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEKAKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIRHFKH
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150......--.--160-........170.......180.......190...-..-----..200---.........210---.......220-....--...230.......240.......250.......260....----.----..270-.......280-..--------------------.-.---...--------------------290.......300.......310.......320.......330.......340.......350......-.-360-........370....---...380.---..---.-.--..390-..-.....400.......410.......420.......430......---.440.......-----------------------------------------------------------------450.......460.......470.......480.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
I
K
R
A
L
ISVSDKT
N
L
V
P
F
V
K
E
L
T
E
L
G
V
E
V
ISTG
G
T
K
K
L
L
Q
ENG
V
D
V
I
G
I
S
EVTG
F
P
E
I
MDG
R
L
K
TLHPNIHG
G
L
L
A
VRG
N
E
E
H
M
A
Q
I
N
EHGIQ
P
I
D
L
V
V
V
N
LY
P
F
K
E
TISKEDV
T
Y
E
E
A
I
ENIDIGGP
G
M
L
RAASKNH
Q
D
V
T
V
I
VDPAD
Y
S
P
V
L
N
Q
I
--
K
--
E
E--GS
V
S
L
Q
K
K
R
E
L
A
A
K
V
F
R
H
T
A
A
Y
D
A
L
I
A
D
Y
L
T
N
V
V-GE-----KEP-----
E
Q
F
T
V
T
F
EKKQS---LRYGENPHQE-
A
T
F
Y
--
Q
TALPVKGSI
A
Q
A
E
Q
LHGKELSYNNIK
D
A
D
A
A
V
Q
I
V
R
E
FT----E----
P
A
A
V
A
-
V
KHMNPCGVG-TG--------------------
K
-
T
---
I
A
E
--------------------
A
F
D
R
A
FEAD
K
T
S
I
F
G
G
I
I
A
LNR
E
V
D
K
A
T
A
E
A
L
H
N
I
F
L
E
I
I
IAPSF
S
Q
E
A
L
D
V
L
TAKKN
L
R
L
L
T
L
D
V
S
A
A
-
V
-
Q
K
--
E
K
Q
L
T
S
VQG
G
L
L
I
Q
D---LDMHGFD---DA---
E
-
I
--SIPTK-RE-P
N
E
Q
E
W
E
D
L
K
L
A
W
K
V
V
K
H
VKSN
A
I
V
L
AKD
N
M
T
V
G
VGAGQMNRVG---S
A
K
I
A
I
EQAGE-----------------------------------------------------------------KAKGSALGSDAYFPM
P
D
T
V
E
E
A
A
KAG
V
T
A
I
IQPGGSIR
D
E
D
SIK
K
A
D
EYG
I
A
M
V
F
T
G
I
R
HFKH
2
PsiBlast_PDB
81.99
43%
-106
- C12 -
4A1O
6
PUR9_MYCTU
A:
[10-523]
--
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
---
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
R
K
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
--
R
--
A
---
G
G
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
-
A
P
-----
E
H
P
VAAFP
Q
W
F
G
R
S
W
R
R
V
A
M
---
L
R
Y
G
E
N
P
H
Q
Q
-
A
A
L
Y
G
D
P
T
A
W
P
---
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
----
Q
----
T
C
V
A
I
-
I
K
H
A
N
P
C
G
I
A
I
S
S
--------------------
V
-
S
---
V
A
D
--------------------
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
N
I
R
V
L
V
--
A
A
E
P
-
L
-
A
G
--
G
S
E
L
R
P
I
S
G
G
L
L
I
Q
Q
S
DQ
L
D
A
H
G
D
N
---
P
A
---
N
-
W
--
T
L
A
T
G
-
S
P
-
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
---
A
A
R
L
A
V
E
R
G
G
E
-----------------------------------------------------------------
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
22
PsiBlast_CBE
81.75
43%
-106
- C12 -
3ZZM
4
PUR9_MYCTU
B:
[10-523]
--
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
R
K
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
--
R
--
A
---
G
G
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
-
A
P
-----
E
H
P
VAAFP
Q
W
F
G
R
S
W
R
R
V
A
M
---
L
R
Y
G
E
N
P
H
Q
Q
-
A
A
L
Y
G
D
P
T
A
W
P
---
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
----
Q
----
T
C
V
A
I
-
I
K
H
A
N
P
C
G
I
A
I
S
S
--------------------
V
-
S
---
V
A
D
--------------------
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
N
I
R
V
L
V
--
A
A
E
P
-
L
-
A
G
--
G
S
E
L
R
P
I
S
G
G
L
L
I
Q
Q
S
DQ
L
D
A
H
G
D
N
---
P
A
---
N
-
W
--
T
L
A
T
G
-
S
P
-
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
---
A
A
R
L
A
V
E
R
G
G
E
-----------------------------------------------------------------
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
1
PsiBlast_PDB
81.56
43%
-101
- C12 -
3ZZM
4
PUR9_MYCTU
A:
[10-523]
--
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
R
K
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
--
R
--
A
---
G
G
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
-
A
P
-----
E
H
P
VAAFP
Q
W
F
G
R
S
W
R
R
V
A
M
---
L
R
Y
G
E
N
P
H
Q
Q
-
A
A
L
Y
G
D
P
T
A
W
P
---
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
----
Q
----
T
C
V
A
I
-
I
K
H
A
N
P
C
G
I
A
I
S
S
--------------------
V
-
S
---
V
A
D
--------------------
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
N
I
R
V
L
V
--
A
A
E
P
-
L
-
A
G
--
G
S
E
L
R
P
I
S
G
G
L
L
I
Q
Q
SDQ
L
D
A
H
G
D
N
---
P
A
---
N
-
W
--
T
L
A
T
G
-
S
P
-
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
---
A
A
R
L
A
V
E
R
G
G
E
-----------------------------------------------------------------
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
21
PsiBlast_CBE
81.02
43%
-104
- C12 -
4A1O
6
PUR9_MYCTU
B:
[10-523]
--
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
R
K
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
--
R
--
A
---
G
G
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
-
A
P
-----
E
H
P
VAAFP
Q
W
F
G
R
S
W
R
R
V
A
M
---
L
R
Y
G
E
N
P
H
Q
Q
-
A
A
L
Y
G
D
P
T
A
W
P
---
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
----
Q
----
T
C
V
A
I
-
I
K
H
A
N
P
C
G
I
A
I
S
S
--------------------
V
-
S
---
V
A
D
--------------------
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
N
I
R
V
L
V
--
A
A
E
P
-
L
-
A
G
--
G
S
E
L
R
P
I
S
G
G
L
L
I
Q
Q
S
DQ
L
D
A
H
G
D
N
---
P
A
---
N
-
W
--
T
L
A
T
G
-
S
P
-
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
---
A
A
R
L
A
V
E
R
G
G
E
-----------------------------------------------------------------
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
40
HHSearch
79.49
44%
-97
* C12 *
3ZZM
4
PUR9_MYCTU
A:
[9-523]
-
P
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
R
K
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
E
S
G
-
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
--
R
--
A
---
G
G
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
-
A
P
EHPVA
A
F
P
-----
Q
W
F
G
R
S
W
R
R
V
A
M
---
L
R
Y
G
E
N
P
H
Q
Q
-
A
A
L
Y
--
G
D
-
P
T
A
W
P
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
----
Q
----
T
C
V
A
I
-
I
K
H
A
N
P
C
G
I
A
-
I
S
--------------------
S
V
S
---
V
A
D
--------------------
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
N
I
R
V
L
V
A
A
E
P
L
A
----
G
--
G
S
E
L
R
P
I
S
G
G
L
L
I
Q
Q
---
S
D
Q
L
D
A
H
GDN
P
A
---
N
-
W
--
T
L
A
T
G
-
S
P
-
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
---
A
A
R
L
A
V
E
R
G
G
E
-----------------------------------------------------------------
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
42
HHSearch
78.83
39%
-88
- C12 -
1G8M
2
PUR9_CHICK
A:
[5-593]
--
Q
Q
L
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
-
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
--
A
--
A
S
KD
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
R
K
E
Y
-
S
-------------------
K
G
V
S
Q
L
P
---
L
R
Y
G
M
N
P
H
Q
S
-
P
A
Q
L
--
Y
T
-
T
R
P
---
K
L
P
L
T
V
V
N
G
S
-
P
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
A
LG
I
----
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLS
E
E
E
A
Q
V
C
MVHDLHKTL
T
-
P
---
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
E
P
D
--
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
---
L
-
F
K-
N
I
V
T
K
-
N
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
N
S
W
W
L
R
H
H
P
R
V
L
S
MKFKAGVK
R
A
E
V
S
N
A
I
D
Q
Y
V
T
GTIGE
D
E
D
L
V
K
W
Q
A
M
F
EEVPAQLT
E
A
E
K
K
Q
W
I
A
K
L
T
A
V
S
L
S
S
D
A
F
F
P
F
R
D
N
V
D
R
A
K
R
I
G
V
Q
F
I
V
A
P
S
G
S
A
A
D
E
V
V
I
E
A
C
N
E
L
G
I
T
L
I
H
T
N
L
R
L
F
H
H
41
HHSearch
71.16
42%
-97
- C12 -
4EHI
7
PUR9_CAMJE
A:
[23-534]
-
N
A
M
R
A
L
L
S
V
S
D
K
E
G
I
V
E
F
G
K
E
L
E
N
L
G
F
E
I
L
S
T
G
G
T
F
K
L
L
K
E
N
G
I
K
V
I
E
V
S
D
F
T
--------------------------------------
I
L
G
I
D
L
V
C
V
N
L
Y
P
F
K
K
T
T
I
M
S
-
D
D
F
D
E
I
I
E
N
I
D
I
G
G
P
A
M
I
R
S
A
A
K
N
Y
K
D
V
M
V
L
C
D
P
L
D
Y
E
K
V
I
E
T
L
--
K
--
K
---
G
Q
N
D
E
N
F
R
L
N
L
M
I
K
A
Y
E
H
T
A
N
Y
D
A
Y
I
A
N
Y
M
N
E
R
F
-
N
G
-----
G
F
G
-----
A
S
K
F
I
V
G
Q
K
V
F
D
---
T
K
Y
G
E
N
P
H
Q
K
-
G
A
L
Y
--
E
F
-
D
A
F
--
F
S
A
N
F
K
A
L
K
G
-
E
A
S
F
N
N
L
T
D
I
N
A
A
L
N
L
A
S
S
F
D
K---
A
----
P
A
I
A
I
-
V
K
H
G
N
P
C
G
F
A
-
I
K
--------------------
E
-
N
---
L
V
Q
--------------------
S
Y
I
H
A
L
K
C
D
S
V
S
A
Y
G
G
V
V
A
I
N
G
T
L
D
E
A
L
A
N
K
I
N
E
I
Y
V
E
V
I
I
A
A
N
V
D
E
K
A
L
A
V
F
E
G
K
K
R
I
K
I
F
T
Q
E
S
P
F
L
I
R
S
F
D
--
K
Y
D
F
K
H
I
D
G
G
F
V
Y
Q
N
---
S
D
E
V
G
E
D
E--
L
K
---
N
-
A
--
K
L
M
S
Q
-
R
E
-
A
S
K
E
E
L
K
D
L
E
I
A
M
K
I
A
A
F
T
K
S
N
N
V
V
Y
V
K
N
G
A
M
V
A
I
G
M
G
M
T
S
R
I
D
---
A
A
K
A
A
I
A
K
A
K
E
M
GL--------------------------------------------------------------
D
L
Q
G
C
V
L
A
S
E
A
F
F
P
F
R
D
S
I
D
E
A
S
K
V
G
V
K
A
I
V
E
P
G
G
S
I
R
D
D
E
V
V
K
A
A
D
E
Y
G
M
A
L
Y
F
T
G
V
R
H
F
L
H
15
PsiBlast_PDB
71.14
36%
-94
- C12 -
1G8M
2
PUR9_CHICK
A:
[8-463]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
Q
L
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
A
LG
I
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLS
E
E
E
A
Q
V
C
MVHDLH---
K
-
T
LT
P
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D
-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
71.11
36%
-97
- C12 -
2B1G
2
PUR9_CHICK
B:
[8-463]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
AA
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
QLP
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
ALGI
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLSEEEAQVCMVHDLH---
K
-
T
LTP
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
70.67
36%
-102
- C12 -
2IU0
2
PUR9_CHICK
B:
[8-463]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
AA
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
QLP
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
ALGI
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLSEEEAQVCMVHDLH---
K
-
T
LTP
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.47
36%
-93
- C12 -
2B1I
5
PUR9_CHICK
A:
[8-463]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
Q
L
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
A
LG
I
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLS
E
E
E
A
Q
V
C
MVHDLH---
K
-
T
LT
P
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
70.20
36%
-97
- C12 -
1THZ
3
PUR9_CHICK
B:
[8-463]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
AA
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
QLP
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
ALGI
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLSEEEAQVCMVHDLH---
K
-
T
LTP
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.12
36%
-96
- C12 -
1OZ0
4
PUR9_CHICK
A:
[28-483]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
Q
L
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
A
LG
I
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLS
E
E
E
A
Q
V
C
MVHDLH---
K
-
T
LT
P
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D
-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
70.08
36%
-97
- C12 -
2B1G
2
PUR9_CHICK
C:
[8-463]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
AA
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
QLP
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
ALGI
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLSEEEAQVCMVHDLH---
K
-
T
LTP
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
69.89
36%
-98
- C12 -
2B1G
2
PUR9_CHICK
A:
[8-463]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
Q
L
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
A
LG
I
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLS
E
E
E
A
Q
V
C
MVHDLH---
K
-
T
LT
P
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D
-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
69.53
36%
-96
- C12 -
2IU3
2
PUR9_CHICK
B:
[8-463]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
AA
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
QLP
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
ALGI
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLSEEEAQVCMVHDLH---
K
-
T
LTP
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
69.43
36%
-95
- C12 -
1PL0
3
PUR9_HUMAN
B:
[7-464]
-----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
A
R
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
--
Q
SS
E
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
F
R
-------------------
K
Q
Y
S
K
G
V
S
-
Q
M
P
---
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
TL
Q
P
K
L
P
I
T
-------
V
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
E
ALGI
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
--------------------
I
-
P
---
L
S
E
DEAKVCMVYDLYKTLTPISA
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
K
K
K
N
G
N
Y
C
V
L
Q
M
D
Q
S
-
Y
-
K
P
--
D
E
N
E
V
R
T
L
F
G
L
H
L
S
Q
---
K
R
N
N
G
V
V
---
D
K
---
S
-
L
FS
N
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.15
36%
-93
- C12 -
1M9N
3
PUR9_CHICK
A:
[28-483]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
Q
L
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
A
LG
I
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLS
E
E
E
A
Q
V
C
MVHDLH---
K
-
T
LT
P
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D
-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
69.12
36%
-94
- C12 -
1OZ0
4
PUR9_CHICK
B:
[28-483]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
AA
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
QLP
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
ALGI
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLSEEEAQVCMVHDLH---
K
-
T
LTP
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
69.09
36%
-96
- C12 -
2B1I
5
PUR9_CHICK
B:
[8-463]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
AA
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
QLP
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
ALGI
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLSEEEAQVCMVHDLH---
K
-
T
LTP
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
68.95
36%
-95
- C12 -
1M9N
4
PUR9_CHICK
B:
[28-483]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
AA
S
--
K
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
-----------------------
F
R
K
E
Y
S
K
G
V
S
QLP
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
--
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
Q
ALGI
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
IPLSEEEAQVCMVHDLH---
K
-
T
LTP
L
A
S
--------------------
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
N
G
G
Y
C
V
L
Q
M
D
P
N
-
Y
-
E
P
D-
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
---
R
N
N
A
V
I
D
---
R
S
LFK
N
-
I
--
V
T
K
N
K
-
T
L
-
P
-
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.68
36%
-94
- C12 -
1P4R
6
PUR9_HUMAN
A:
[7-462]
-----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
-
R
N
I
P
E
D
N
A
D
M
A
R
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
--
Q
S
S
E
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
F
R
-------------------
K
Q
Y
S
K
G
V
S
-
Q
M
P
---
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
T
L
Q
P
K
L
P
I
T
-------
V
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
----
E
A
LG
I
P
A
A
A
S
-
F
K
H
V
S
P
A
G
A
A
-
V
G
--------------------
I
-
P
---
L
S
E
D
E
A
K
V
C
MVYDLYKTLT
P
I
S
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
K
K
K
N
G
N
Y
C
V
L
Q
M
D
Q
S
-
Y
-
K
P
--
D
E
N
E
V
R
T
L
F
G
L
H
L
S
Q
---
K
R
N
N
G
V
V
---
D
K
---
S
-
L
FS
N
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
---
C
T
R
L
A
G
D
K
A
----------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.30
40%
-92
- C12 -
4EHI
7
PUR9_CAMJE
A:
[26-534]
----
R
A
L
L
S
V
S
D
K
E
G
I
V
E
F
G
K
E
L
E
N
L
G
F
E
I
L
S
T
G
G
T
F
K
L
L
K
E
N
G
I
K
V
I
E
V
S
D
F
T
--------------------------------------
I
L
G
I
D
L
V
C
V
N
L
Y
P
F
K
K
T
T
I
M
S
D
-
D
F
D
E
I
I
E
N
I
D
I
G
G
P
A
M
I
R
S
A
A
K
N
Y
K
D
V
M
V
L
C
D
P
L
D
Y
E
K
V
I
E
T
L
--
K
---
K
--
G
Q
N
D
E
N
F
R
L
N
L
M
I
K
A
Y
E
H
T
A
N
Y
D
A
Y
I
A
N
Y
M
N
E
R
F
N
G
G
-----
F
G
A
-----
S
K
F
I
V
G
-
Q
K
V
F
D
---
T
K
Y
G
E
N
P
H
Q
K
-
G
A
L
Y
--
E
F
D
A
F
F
S
---
A
N
F
K
A
L
K
G
-
E
A
S
F
N
N
L
T
D
I
N
A
A
L
N
L
A
S
S
F
D
----
K
----
A
P
A
I
A
I
V
K
H
G
N
P
C
G
F
A
-
I
K
--------------------
E
-
N
---
L
V
Q
--------------------
S
Y
I
H
A
L
K
C
D
S
V
S
A
Y
G
G
V
V
A
I
N
G
T
L
D
E
A
L
A
N
K
I
N
E
I
Y
V
E
V
I
I
A
A
N
V
D
E
K
A
L
A
V
F
E
G
K
K
R
I
K
I
F
T
Q
E
S
P
F
L
-
I
-
R
S
F
D
K
Y
D
F
K
H
I
D
G
G
F
V
Y
Q
N
---
S
D
E
V
G
E
D
---
E
L
---
K
N
A
--
K
L
M
S
Q
-
R
E
-
A
S
K
E
E
L
K
D
L
E
I
A
M
K
I
A
A
F
T
K
S
N
N
V
V
Y
V
K
N
G
A
M
V
A
I
G
M
G
M
T
S
R
I
D
A
A
K
A
A
I
A
K
A
K
E
M
G
L
-----------------------------------------------------------------
D
L
Q
G
C
V
L
A
S
E
A
F
F
P
F
R
D
S
I
D
E
A
S
K
V
G
V
K
A
I
V
E
P
G
G
S
I
R
D
D
E
V
V
K
A
A
D
E
Y
G
M
A
L
Y
F
T
G
V
R
H
F
L
H