@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06530: (2016-06-10 )
MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLVNIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGSKQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEEEAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFDGDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTENGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASEGYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARDRVYKAVDEIFKPGLFFRKDIGARALKAAQK
Atome Classification :
(20 SA)
.........10.........20........30-....--.-...--40..--..--.-...50........60........70........80........90........100.......110.......120.......130.......-140.......150.......160.......170.......180.......190.......200.......210.......220.......230-.......-240.......-250........260.......270.....-..-280.......290.......300......---.----310----........--320.-.....-----...330--........340--.---....-...--350.-.--.--.-...----.-----.360......-.370.......380.......390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
V
L
I
I
GKGG-RE
H
T
L
A
W
K
A
A
Q
S
S
L
V
E
N
V
FAA-PGND--G-MAA--S
A
Q
L
--
V
N
--I-EESDH
A
G
L
V
S
F
AKQNQV
G
L
T
I
VGPEV
P
L
I
E
G
L
V
D
E
F
E
KAG
L
H
V
FGP
S
K
A
A
A
I
I
EG
S
K
Q
F
A
K
D
L
M
K
KYDIPT
A
E
Y
E
TFT
S
F
D
E
A
K
A
Y
V
Q
EKG
A
P
-
I
V
I
KADGLAAGK
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
DEKFGD
A
S
A
S
V
V
I
E
E
YLSGE
E
F
S
L
M
A
F
V
KG
E
K
V
Y
P
M
V
I
AQD
H
K
RAFDGDKGPNTGGMGAYS-PVPQI
S
E
-
E
T
V
R
H
A
V
E
T
I
-
V
-
K
P
A
A
K
A
M
V
Q
EGR
S
F
T
G
V
L
Y
A
G
L
M
LTEN-G
S
-
K
V
I
E
F
N
ARFGDPE
T
Q
V
V
L
PR
M
E
S
D
L
V
Q
V
L
---
L
----
D
L-----LDDKEV
D
L
--
R
--W-KDT
A
A
-----
V
S
V
V
L
---ASEGYPESYA---K---GTPI-GSL--A--A-E--T--
E
-
Q
V
V
----
V
-----
F
HAGTKAEGG-
E
F
VTNG
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
FKPGLF
F
R
K
D
I
G
A
R
A
L
K
AAQK
1
PsiBlast_PDB
93.46
100%
-90
- C1 -
2XD4
4
PUR2_BACSU
A:
[1-422]
M
N
V
L
I
I
G
K
G
G
-
R
E
H
T
L
A
W
K
A
A
Q
S
S
L
V
E
N
V
F
A
A
-
P
G
N
D
--
G
-
M
A
A
--
S
A
Q
L
--
V
N
--
I
-
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
E
-
E
T
V
R
H
A
V
E
T
I
-
V
-
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
N
-
G
S
-
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
---
L
----
D
L
-----
L
D
D
K
E
V
D
L
--
R
--
W
-
K
D
T
A
A
-----
V
S
V
V
L
---
A
S
E
G
Y
P
E
S
Y
A
---
K
---
G
T
P
I
-
G
S
L
--
A
--
A
-
E
--
T
--
E
-
Q
V
V
----
V
-----
F
H
A
G
T
K
A
E
G
G
-
E
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
A
A
Q
K
2
PsiBlast_PDB
91.93
97%
-93
- C1 -
2XCL
2
PUR2_BACSU
A:
[2-422]
-
N
V
L
I
I
G
K
G
G
-
R
E
H
T
L
A
W
K
A
A
Q
S
S
L
V
E
N
V
F
A
A
-
P
G
N
D
--
G
-
M
A
A
--
S
A
Q
L
--
V
N
--
I
-
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
E
-
E
T
V
R
H
A
V
E
T
I
-
V
-
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
N
-
G
S
-
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
---
L
----
D
L
-----
L
D
D
K
E
V
D
L
--
R
--
W
-
K
D
T
A
A
-----
V
S
V
V
L
---
A
S
E
G
Y
P
E
S
Y
A
---
K
---
G
T
P
I
-
G
S
L
--
A
--
A
-
E
--
T
--
E
-
Q
V
V
----
V
-----
F
H
A
G
T
K
A
E
G
G
-
E
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
A
A
Q
K
32
HHSearch
89.83
96%
-93
- C1 -
2XCL
2
PUR2_BACSU
A:
[1-422]
M
N
V
L
I
I
G
K
G
G
-
R
E
H
T
L
A
W
K
A
A
Q
S
S
L
V
E
N
V
F
A
A
-
P
G
N
D
--
G
-
M
A
A
--
S
A
Q
L
--
V
N
--
I
-
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
E
E
T
V
R
H
A
V
E
-
T
I
-
V
-
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
N
-
G
S
-
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
---
L
----
D
L
-----
L
D
D
K
E
V
D
L
--
R
--
W
-
K
D
T
A
A
-----
V
-
S
V
V
---
L
-
A
-
S
E
G
Y
P
E
---
S
Y
A
K
G
T
P
I
-
G
S
L
--
A
--
A
-
E
--
T
--
E
-
Q
V
V
----
V
-----
F
H
A
G
T
K
A
E
G
G
-
E
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
A
A
Q
K
5
PsiBlast_PDB
82.44
62%
-110
- C1 -
2YS6
2
?
A:
[22-439]
M
N
V
L
V
I
G
R
G
G
-
R
E
H
A
I
A
W
K
A
A
Q
S
P
L
V
G
K
L
Y
V
A
-
P
G
N
P
--
G
-
I
A
D
--
V
A
E
L
--
V
H
--
I
-
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
D
-
E
M
M
D
A
A
L
E
A
I
-
L
-
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
N
-
G
P
-
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
---
L
----
A
V
-----
M
D
G
K
E
L
E
L
--
E
--
W
-
T
D
E
A
V
-----
L
G
V
V
L
---
A
A
K
G
Y
P
G
A
Y
E
---
R
---
G
A
E
I
-
R
G
L
--
D
--
R
-
I
--
S
--
P
-
D
A
L
----
L
-----
F
H
A
G
T
K
R
E
G
G
-
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
E
----
3
PsiBlast_PDB
82.33
62%
-112
- C1 -
2YRW
1
?
A:
[22-439]
M
N
V
L
V
I
G
R
G
G
-
R
E
H
A
I
A
W
K
A
A
Q
S
P
L
V
G
K
L
Y
V
A
-
P
G
N
P
--
G
-
I
A
D
--
V
A
E
L
--
V
H
--
I
-
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
------
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
D
-
E
M
M
D
A
A
L
E
A
I
-
L
-
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
N
-
G
P
-
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
---
L
----
A
V
-----
M
D
G
K
E
L
E
L
--
E
--
W
-
T
D
E
A
V
-----
L
G
V
V
L
---
A
A
K
G
Y
P
G
A
Y
E
---
R
---
G
A
E
I
-
R
G
L
--
D
--
R
-
I
--
S
--
P
-
D
A
L
----
L
-----
F
H
A
G
T
K
R
E
G
G
-
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
E
----
4
PsiBlast_PDB
82.04
62%
-109
- C1 -
2YRX
3
?
A:
[22-438]
M
N
V
L
V
I
G
R
G
G
-
R
E
H
A
I
A
W
K
A
A
Q
S
P
L
V
G
K
L
Y
V
A
-
P
G
N
P
--
G
-
I
A
D
--
V
A
E
L
--
V
H
--
I
-
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
D
-
E
M
M
D
A
A
L
E
A
I
-
L
-
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
N
-
G
P
-
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
---
L
----
A
V
-----
M
D
G
K
E
L
E
L
--
E
--
W
-
T
D
E
A
V
-----
L
G
V
V
L
---
A
A
K
G
Y
P
G
A
Y
E
---
R
---
G
A
E
I
-
R
G
L
--
D
--
R
-
I
--
S
--
P
-
D
A
L
----
L
-----
F
H
A
G
T
K
R
E
G
G
-
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
-----
33
HHSearch
81.62
61%
-110
- C1 -
2YRX
3
?
A:
[22-438]
M
N
V
L
V
I
G
R
G
G
R
E
H
A
I
A
W
K
-
A
A
Q
S
P
L
V
G
K
L
Y
V
A
-
P
G
N
P
--
G
-
I
A
D
--
V
A
E
L
--
V
H
--
I
-
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
D
-
E
M
M
D
A
A
L
E
A
I
-
L
-
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
N
-
G
P
-
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
---
L
----
A
V
-----
M
D
G
K
E
L
E
L
--
E
--
W
-
T
D
E
A
V
-----
L
G
V
V
L
---
A
A
K
G
Y
P
G
A
Y
E
---
R
---
G
A
E
I
-
R
G
L
--
D
--
R
-
I
--
S
--
P
-
D
A
L
----
L
-----
F
H
A
G
T
K
R
E
G
G
-
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
-----
21
PsiBlast_CBE
76.74
52%
-91
- C1 -
2YW2
2
PUR2_AQUAE
B:
[1-420]
M
K
V
L
V
V
G
N
G
G
-
R
E
H
A
I
A
W
K
V
A
Q
S
P
L
V
K
E
L
Y
V
A
-
K
G
N
A
--
G
-
I
W
E
--
I
A
K
R
--
V
D
--
I
-
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
T
P
V
I
N
E
-
E
V
E
K
R
I
R
E
E
I
-
V
-
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
E
-
G
P
-
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
---
L
----
N
F
-----
Y
E
G
K
D
V
H
I
--
K
--
E
-
D
E
R
Y
A
-----
L
D
V
V
L
---
A
S
R
G
Y
P
E
K
P
E
---
T
---
G
K
I
I
-
H
G
L
DY
L
--
K
-
S
--
M
--
E
-
D
V
V
----
V
-----
F
H
A
G
T
K
K
E
G
N
-
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
----
7
PsiBlast_PDB
76.63
52%
-89
- C1 -
2YW2
2
PUR2_AQUAE
A:
[1-420]
M
K
V
L
V
V
G
N
G
G
-
R
E
H
A
I
A
W
K
V
A
Q
S
P
L
V
K
E
L
Y
V
A
-
K
G
N
A
--
G
-
I
W
E
--
I
A
K
R
--
V
D
--
I
-
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
T
P
V
I
N
E
-
E
V
E
K
R
I
R
E
E
I
-
V
-
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
E
-
G
P
-
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
---
L
----
N
F
-----
Y
E
G
K
D
V
H
I
--
K
--
E
-
D
E
R
Y
A
-----
L
D
V
V
L
---
A
S
R
G
Y
P
E
K
P
E
---
T
---
G
K
I
I
-
H
G
L
D
Y
L
--
K
-
S
--
M
--
E
-
D
V
V
----
V
-----
F
H
A
G
T
K
K
E
G
N
-
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
----
10
PsiBlast_PDB
76.29
51%
-97
- C1 -
3MJF
12
PUR2_YERPE
A:
[5-427]
-
N
I
L
I
I
G
N
G
G
-
R
E
H
A
L
G
W
K
A
A
Q
S
P
L
A
D
K
I
Y
V
A
-
P
G
N
A
--
G
-
T
A
L
--
E
P
T
L
E
N
V
D
--
I
-
A
A
T
D
I
A
G
L
L
A
F
A
Q
S
H
D
I
G
L
T
I
V
G
P
E
A
P
L
V
I
G
V
V
D
A
F
R
A
A
G
L
A
I
F
G
P
T
Q
A
A
A
Q
L
E
G
S
K
A
F
T
K
D
F
L
A
R
H
N
I
P
S
A
E
Y
Q
N
F
T
D
V
E
A
A
L
A
Y
V
R
Q
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
I
V
A
M
T
Q
E
E
A
E
T
A
V
N
D
M
L
A
G
N
A
F
G
D
A
G
H
R
I
V
V
E
E
F
L
D
G
E
E
A
S
F
I
V
M
V
D
G
E
N
V
L
P
M
A
T
S
Q
D
H
K
R
V
G
D
G
D
T
G
P
N
T
G
G
M
G
A
Y
S
-
P
A
P
V
V
T
D
-
D
V
H
Q
R
V
M
D
Q
V
-
I
-
W
P
T
V
R
G
M
A
A
E
G
N
I
Y
T
G
F
L
Y
A
G
L
M
I
S
A
D
-
G
Q
P
K
V
I
E
F
N
C
R
F
G
D
P
E
T
Q
P
I
M
L
R
M
R
S
D
L
V
E
L
C
---
L
A
G
T
Q
G
K
-----
L
N
E
K
T
S
D
------
W
-
D
E
R
P
S
-----
L
G
V
V
L
---
A
A
G
G
Y
P
A
D
Y
R
---
Q
---
G
D
V
I
-
H
G
L
--
P
Q-
Q
-
E
--
V
--
K
-
D
G
K
----
V
-----
F
H
A
G
T
K
L
N
G
N
H
E
V
V
T
N
G
G
R
V
L
C
V
T
A
L
G
E
T
V
A
Q
A
Q
Q
Y
A
Y
Q
L
A
E
G
I
Q
W
E
G
V
F
C
R
K
D
I
G
Y
R
A
I
-----
8
PsiBlast_PDB
74.72
52%
-91
- C1 -
2YYA
-
PUR2_AQUAE
A:
[1-420]
M
K
V
L
V
V
G
N
G
G
-
R
E
H
A
I
A
W
K
V
A
Q
S
P
L
V
K
E
L
Y
V
A
-
K
G
N
A
--
G
-
I
W
E
--
I
A
K
R
--
V
D
--
I
-
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
T
P
V
I
N
E
-
E
V
E
K
R
I
R
E
E
I
-
V
-
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
E
-
G
P
-
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
---
L
----
N
F
-----
Y
E
G
K
D
V
H
I
--
K
--
E
-
D
E
R
Y
A
-----
L
D
V
V
L
---
A
S
R
G
Y
P
E
K
P
E
---
T
---
G
K
I
I
-
H
G
L
D
Y
L
--
K
-
S
--
M
--
E
-
D
V
V
----
V
-----
F
H
A
G
T
K
K
E
G
N
-
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
----
12
PsiBlast_PDB
74.23
48%
-101
- C1 -
2IP4
2
?
A:
[2-412]
-
K
V
L
V
V
G
S
G
G
-
R
E
H
A
L
L
W
K
A
A
Q
S
P
R
V
K
R
L
Y
A
A
-
P
G
N
A
--
G
-
M
E
A
--
L
A
E
L
--
V
P
--
W
-
N
-
G
D
V
E
A
L
A
D
W
A
L
A
E
G
I
D
L
T
L
V
G
P
E
A
P
L
V
E
G
I
A
D
A
F
Q
A
R
G
L
L
L
F
G
P
T
Q
K
A
A
M
I
E
G
S
K
A
F
A
K
G
L
M
E
R
Y
G
I
P
T
A
R
Y
R
V
F
R
E
P
L
E
A
L
A
Y
L
E
E
V
G
V
P
-
V
V
V
K
D
S
G
L
A
A
G
K
G
V
T
V
A
F
D
L
H
Q
A
K
Q
A
V
A
N
I
L
N
R
A
E
G
G
E
----
V
V
V
E
E
Y
L
E
G
E
E
A
T
V
L
A
L
T
D
G
E
T
I
L
P
L
L
P
S
Q
D
H
K
R
L
L
D
G
D
Q
G
P
M
T
G
G
M
G
A
V
A
-
P
Y
P
M
-
D
E
-
A
T
L
R
R
V
E
E
E
I
-
L
-
G
P
L
V
R
G
L
R
A
E
G
V
V
Y
R
G
V
V
Y
A
G
L
M
L
T
R
E
-
G
P
-
K
V
L
E
F
N
A
R
F
G
D
P
E
A
Q
A
L
L
P
L
L
E
N
D
L
V
E
L
A
---
L
----
R
V
-----
A
E
G
R
L
A
G
T
--
R
L
S
W
-
K
E
G
A
A
-----
A
C
V
V
L
---
A
A
P
G
Y
P
E
S
P
R
---
K
---
G
I
P
L
--
H
V
--
P
--
E
-
P
--
P
--
E
-
G
V
L
----
V
-----
F
H
A
G
T
R
R
E
G
G
-
R
L
V
S
A
G
G
R
V
L
N
V
V
G
L
G
R
D
L
K
E
A
L
E
R
A
Y
A
Y
I
P
Q
V
G
F
P
G
A
V
Y
R
R
D
I
G
R
R
A
L
-----
13
PsiBlast_PDB
74.03
41%
-102
- C1 -
3LP8
6
?
A:
[22-440]
M
N
V
L
V
I
G
S
G
G
-
R
E
H
S
M
L
H
H
I
R
K
S
T
L
L
N
K
L
F
I
A
-
P
G
R
E
--
G
-
M
S
G
--
L
A
D
I
--
I
D
--
I
-
D
I
N
S
T
I
E
V
I
Q
V
C
K
K
E
K
I
E
L
V
V
I
G
P
E
T
P
L
M
N
G
L
S
D
A
L
T
E
E
G
I
L
V
F
G
P
S
K
A
A
A
R
L
E
S
S
K
G
F
T
K
E
L
C
M
R
Y
G
I
P
T
A
K
Y
G
Y
F
V
D
T
N
S
A
Y
K
F
I
D
K
H
K
L
P
-
L
V
V
K
A
D
G
L
A
Q
G
K
G
T
V
I
C
H
T
H
E
E
A
Y
N
A
V
D
A
M
L
V
H
H
K
F
G
E
A
G
C
A
I
I
I
E
E
F
L
E
G
K
E
I
S
F
F
T
L
V
D
G
S
N
P
V
I
L
G
V
A
Q
D
Y
K
T
I
G
D
N
N
K
G
P
N
T
G
G
M
G
S
Y
S
-
K
P
N
I
I
T
Q
-
E
M
E
H
I
I
I
Q
K
I
-
I
-
Y
P
T
I
K
A
M
F
N
M
N
I
Q
F
R
G
L
L
F
A
G
I
I
I
K
K
N
-
E
P
-
K
L
L
E
Y
N
V
R
F
G
D
P
E
T
Q
S
I
L
P
R
L
N
S
D
F
L
K
-
L
---
L
----
S
L
T
A
K
GK
L
G
N
E
S
V
E
L
--
S
--
K
-
K
--
A
A
-----
L
C
V
V
V
---
A
S
R
G
Y
P
G
E
Y
K
---
K
---
N
S
I
I
-
N
G
I
E
N
I
--
E
-
K
--
L
--
P
-
N
V
Q
----
L
-----
L
H
A
G
T
R
R
E
G
N
-
N
W
V
S
D
S
G
R
V
I
N
V
V
A
Q
G
E
N
L
A
S
A
K
H
Q
A
Y
A
A
L
D
L
L
D
W
P
D
G
I
Y
R
Y
D
I
G
S
C
-------
11
PsiBlast_PDB
73.93
47%
-101
- C1 -
2QK4
5
PUR2_HUMAN
A:
[26-451]
-
R
V
L
I
I
G
S
G
G
-
R
E
H
T
L
A
W
K
L
A
Q
S
H
H
V
K
Q
V
L
V
A
-
P
G
N
A
--
G
-
T
A
C
--
S
E
K
I
--
S
N
T
A
I
-
S
I
S
D
H
T
A
L
A
Q
F
C
K
E
K
K
I
E
F
V
V
V
G
P
E
A
P
L
A
A
G
I
V
G
N
L
R
S
A
G
V
Q
C
F
G
P
T
A
E
A
A
Q
L
E
S
S
K
R
F
A
K
E
F
M
D
R
H
G
I
P
T
A
Q
W
K
A
F
T
K
P
E
E
A
C
S
F
I
L
S
A
D
F
P
A
L
V
V
K
A
S
G
L
---
K
G
V
I
V
A
K
S
K
E
E
A
C
K
A
V
Q
E
I
M
Q
E
-------
E
T
I
V
I
E
E
L
L
D
G
E
E
V
S
C
L
C
F
T
D
G
K
T
V
A
P
M
P
P
A
Q
D
H
K
R
L
L
E
G
D
G
G
P
N
T
G
G
M
G
A
Y
C
-
P
A
P
Q
V
S
N
-
D
L
L
L
K
I
K
D
T
V
-
L
-
Q
R
T
V
D
G
M
Q
Q
E
G
T
P
Y
T
G
I
L
Y
A
G
I
M
L
T
K
N
-
G
P
-
K
V
L
E
F
N
C
R
F
G
D
P
E
C
Q
V
I
L
P
L
L
K
S
D
L
Y
E
V
I
Q
S
T
L
----
D
G
-----
L
L
C
T
S
L
P
V
--
W
--
L
-
E
N
H
T
A
-----
L
T
V
V
M
---
A
S
K
G
Y
P
G
D
Y
T
---
K
---
G
V
E
I
T
G
F
P
--
E
--
A
-
Q
--
A
--
L
-
G
L
E
----
V
-----
F
H
A
G
T
A
L
K
N
G
-
K
V
V
T
H
G
G
R
V
L
A
V
T
A
I
R
E
N
L
I
S
A
L
E
E
A
K
K
G
L
A
A
I
K
F
E
G
A
I
Y
R
K
D
I
G
F
R
A
I
A
F
L
--
36
HHSearch
72.17
48%
-103
- C1 -
2IP4
2
?
A:
[1-414]
M
K
V
L
V
V
G
S
G
G
-
R
E
H
A
L
L
W
K
A
A
Q
S
P
R
V
K
R
L
Y
A
A
-
P
G
N
A
--
G
-
M
E
A
--
L
A
----
E
L
--
V
P
W
N
G
D
V
E
A
L
A
D
W
A
L
A
E
G
I
D
L
T
L
V
G
P
E
A
P
L
V
E
G
I
A
D
A
F
Q
A
R
G
L
L
L
F
G
P
T
Q
K
A
A
M
I
E
G
S
K
A
F
A
K
G
L
M
E
R
Y
G
I
P
T
A
R
Y
R
V
F
R
E
P
L
E
A
L
A
Y
L
E
E
V
G
V
P
-
V
V
V
K
D
S
G
L
A
A
G
K
G
V
T
V
A
F
D
L
H
Q
A
K
Q
A
V
A
N
I
L
N
R
----
A
E
G
G
E
V
V
V
E
E
Y
L
E
G
E
E
A
T
V
L
A
L
T
D
G
E
T
I
L
P
L
L
P
S
Q
D
H
K
R
L
L
D
G
D
Q
G
P
M
T
G
G
M
G
A
V
A
-
P
Y
P
M
-
D
E
-
A
T
L
R
R
V
E
E
E
I
-
L
-
G
P
L
V
R
G
L
R
A
E
G
V
V
Y
R
G
V
V
Y
A
G
L
M
L
T
R
E
-
G
P
-
K
V
L
E
F
N
A
R
F
G
D
P
E
A
Q
A
L
L
P
L
L
E
N
D
L
V
E
L
A
---
L
----
R
V
-----
A
E
G
R
L
A
G
T
--
R
L
S
W
-
K
E
G
A
A
-----
A
C
V
V
L
---
A
---
A
P
G
Y
P
E
S
P
R
K
---
G
I
P
L
--
H
V
--
P
--
E
-
P
--
P
--
E
-
G
V
L
----
V
F
H
A
G
T
R
R
E
G
G
R
L
------
V
S
A
G
G
R
V
L
N
V
V
G
L
G
R
D
L
K
E
A
L
E
R
A
Y
A
Y
I
P
Q
V
G
F
P
G
A
V
Y
R
R
D
I
G
R
R
A
L
A
R
---
34
HHSearch
72.17
49%
-93
- C1 -
2YW2
2
PUR2_AQUAE
A:
[1-421]
M
K
V
L
V
V
G
N
G
G
-
R
E
H
A
I
A
W
K
V
A
Q
S
P
L
V
K
E
L
Y
V
A
K
G
N
A
G
--
I
-
W
E
I
--
A
K
R
---
V
D
--
I
-
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
T
P
V
I
N
E
-
E
V
E
K
R
I
R
E
E
I
-
V
-
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
E
-
G
P
-
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
---
L
----
N
F
-----
Y
E
G
K
D
V
H
I
--
K
--
E
-
D
E
R
Y
A
-----
L
D
V
V
L
A
S
R
G
Y
P
E
K
P
E
T
G
K
---
I
---
I
H
G
L
-
D
Y
L
-----
K
-
S
--
M
--
E
-
D
V
V
----
V
F
H
A
GT
K
K
E
G
N
F
T
V
------
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
Y
---
35
HHSearch
72.04
40%
-96
- C1 -
3LP8
6
?
A:
[22-440]
M
N
V
L
V
I
G
S
G
G
-
R
E
H
S
M
L
H
H
I
R
K
S
T
L
L
N
K
L
F
I
A
-
P
G
R
E
--
G
M
S
G
L
--
A
D
-
I
--
I
D
--
I
-
D
I
N
S
T
I
E
V
I
Q
V
C
K
K
E
K
I
E
L
V
V
I
G
P
E
T
P
L
M
N
G
L
S
D
A
L
T
E
E
G
I
L
V
F
G
P
S
K
A
A
A
R
L
E
S
S
K
G
F
T
K
E
L
C
M
R
Y
G
I
P
T
A
K
Y
G
Y
F
V
D
T
N
S
A
Y
K
F
I
D
K
H
K
L
P
-
L
V
V
K
A
D
G
L
A
Q
G
K
G
T
V
I
C
H
T
H
E
E
A
Y
N
A
V
D
A
M
L
V
H
H
K
F
G
E
A
G
C
A
I
I
I
E
E
F
L
E
G
K
E
I
S
F
F
T
L
V
D
G
S
N
P
V
I
L
G
V
A
Q
D
Y
K
T
I
G
D
N
N
K
G
P
N
T
G
G
M
G
S
Y
S
K
P
N
I
I
-
T
Q
-
E
M
E
H
I
I
I
Q
K
I
-
I
-
Y
P
T
I
K
A
M
F
N
M
N
I
Q
F
R
G
L
L
F
A
G
I
I
I
K
K
N
-
E
P
-
K
L
L
E
Y
N
V
R
F
G
D
P
E
T
Q
S
I
L
P
R
L
N
S
D
F
L
K
L
L
---
S
----
L
T
-----
A
K
G
K
L
G
N
E
S
V
E
--
L
-
S
K
K
A
A
-----
L
C
V
V
V
---
A
S
R
G
Y
P
G
E
Y
K
---
K
---
N
S
I
I
-
N
G
I
--
E
N
I
E
-
K
--
L
--
P
-
N
V
Q
----
L
-----
L
H
A
G
T
R
R
E
G
N
-
N
W
V
S
D
S
G
R
V
I
N
V
V
A
Q
G
E
N
L
A
S
A
K
H
Q
A
Y
A
A
L
D
L
L
D
W
P
D
G
I
Y
R
Y
D
I
G
S
C
-------
37
HHSearch
71.60
46%
-102
- C1 -
2QK4
5
PUR2_HUMAN
A:
[25-448]
A
R
V
L
I
I
G
S
G
G
-
R
E
H
T
L
A
W
K
L
A
Q
S
H
H
V
K
Q
V
L
V
A
-
P
G
N
A
GT
A
-
C
S
E
--
K
I
S
N
--
T
A
--
I
-
S
I
S
D
H
T
A
L
A
Q
F
C
K
E
K
K
I
E
F
V
V
V
G
P
E
A
P
L
A
A
G
I
V
G
N
L
R
S
A
G
V
Q
C
F
G
P
T
A
E
A
A
Q
L
E
S
S
K
R
F
A
K
E
F
M
D
R
H
G
I
P
T
A
Q
W
K
A
F
T
K
P
E
E
A
C
S
F
I
L
S
A
D
F
P
A
L
V
V
K
A
S
G
L
---
K
G
V
I
V
A
K
S
K
E
E
A
C
K
A
V
Q
E
I
M
Q
E
-------
E
T
I
V
I
E
E
L
L
D
G
E
E
V
S
C
L
C
F
T
D
G
K
T
V
A
P
M
P
P
A
Q
D
H
K
R
L
L
E
G
D
G
G
P
N
T
G
G
M
G
A
Y
C
-
P
A
P
Q
V
S
N
-
D
L
L
L
K
I
K
-
D
T
V
L
-
Q
R
T
V
D
G
M
Q
Q
E
G
T
P
Y
T
G
I
L
Y
A
G
I
M
L
T
K
N
-
G
P
-
K
V
L
E
F
N
C
R
F
G
D
P
E
C
Q
V
I
L
P
L
L
K
S
D
L
Y
E
V
I
---
Q
----
S
T
-----
L
D
G
L
L
C
T
S
--
L
P
V
W
L
E
N
H
T
A
-----
L
T
V
V
M
---
A
S
K
G
Y
P
G
D
Y
T
---
K
---
G
V
E
I
-
T
G
F
--
P
--
E
-
A
Q
A
L
--
G
L
E
V
F
H
A
G
T
A
-----
L
K
N
G
K
V
V
T
-------
H
G
G
R
V
L
A
V
T
A
I
R
E
N
L
I
S
A
L
E
E
A
K
K
G
L
A
A
I
K
F
E
G
A
I
Y
R
K
D
I
G
F
R
A
I
-----
38
HHSearch
67.86
49%
-93
- C1 -
3MJF
12
PUR2_YERPE
A:
[4-428]
M
N
I
L
I
I
G
N
G
G
-
R
E
H
A
L
G
W
K
A
A
Q
S
P
L
A
D
K
I
Y
V
A
-
P
G
N
A
--
G
-
T
A
L
EP
T
L
E
N
--
V
D
--
I
-
A
A
T
D
I
A
G
L
L
A
F
A
Q
S
H
D
I
G
L
T
I
V
G
P
E
A
P
L
V
I
G
V
V
D
A
F
R
A
A
G
L
A
I
F
G
P
T
Q
A
A
A
Q
L
E
G
S
K
A
F
T
K
D
F
L
A
R
H
N
I
P
S
A
E
Y
Q
N
F
T
D
V
E
A
A
L
A
Y
V
R
Q
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
I
V
A
M
T
Q
E
E
A
E
T
A
V
N
D
M
L
A
G
N
A
F
G
D
A
G
H
R
I
V
V
E
E
F
L
D
G
E
E
A
S
F
I
V
M
V
D
G
E
N
V
L
P
M
A
T
S
Q
D
H
K
R
V
G
D
G
D
T
G
P
N
T
G
G
M
G
A
Y
S
-
P
A
P
V
V
T
D
-
D
V
H
Q
R
V
M
D
Q
V
-
I
W
P
T
V
R
G
M
A
A
E
G
N
I
-
Y
T
G
F
L
Y
A
G
L
M
I
S
A
D
G
Q
P
-
K
V
I
E
F
N
C
R
F
G
D
P
E
T
Q
P
I
M
L
R
M
R
S
D
L
V
E
L
C
---
L
----
A
G
-----
T
Q
G
K
L
N
E
K
--
T
S
D
W
-
D
E
R
P
S
L
G
V
V
L
A
A
G
G
Y
---
P
A
D
Y
R
Q
G
D
V
-----------
I
-
H
G
L
--
P
--
Q
Q
E
--
V
KD
G
-
K
V
F
----
H
A
G
T
K
-
L
N
G
N
H
E
V
------
V
T
N
G
G
R
V
L
C
V
T
A
L
G
E
T
V
A
Q
A
Q
Q
Y
A
Y
Q
L
A
E
G
I
Q
W
E
G
V
F
C
R
K
D
I
G
Y
R
A
I
A
----
14
PsiBlast_PDB
62.86
34%
-75
- C1 -
1VKZ
-
PUR2_THEMA
A:
[16-410]
V
R
V
H
I
L
G
S
G
G
-
R
E
H
A
I
G
W
A
F
A
K
Q
G
Y
--
E
V
H
F
Y
-
P
G
N
A
--
G
-
T
K
R
--
D
G
T
----------
N
H
P
Y
E
G
E
K
T
L
K
A
I
P
E
E
D
I
V
I
P
G
S
E
E
F
L
V
E
-----
R
S
----
N
V
F
G
P
V
K
E
V
A
R
L
E
G
S
K
V
Y
A
K
R
F
M
K
K
Y
G
I
R
T
A
R
F
E
V
A
E
T
P
E
E
L
R
E
K
I
K
K
F
S
P
P
-
Y
V
I
K
A
D
G
L
A
R
G
K
G
V
L
I
L
D
S
K
E
E
T
I
E
K
G
S
K
L
I
I
G
E
L
I
K
G
V
K
G
P
V
V
I
D
E
F
L
A
G
N
E
L
S
A
M
A
V
V
N
G
R
N
F
V
I
L
P
F
V
R
D
Y
K
R
L
M
D
G
D
R
G
P
N
T
G
G
M
G
S
W
G
-
P
V
-
E
I
P
S
-
D
T
I
K
K
-
I
E
E
L
-
F
-
D
K
T
L
W
G
V
E
K
E
G
Y
A
Y
R
G
F
L
Y
L
G
L
M
L
H
D
G
-
D
P
-
Y
I
L
E
Y
N
V
R
L
G
D
P
E
T
E
V
I
V
T
L
N
P
E
G
F
V
N
A
V
---
L
----
E
G
-----
Y
R
G
G
K
M
E
P
--
V
--
E
-
P
R
G
F
A
-----
V
D
V
V
L
---
A
A
R
G
Y
P
D
A
P
E
---
K
---
G
K
E
I
---------
T
-
L
--
P
--
E
-
E
G
L
----
I
-----
F
F
A
G
V
A
E
K
D
G
-
K
L
V
T
N
G
G
R
V
L
H
C
M
G
T
G
E
T
K
E
E
A
R
R
K
A
Y
E
L
A
E
K
V
H
F
E
G
K
T
Y
R
R
D
I
----------