@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06960: (2016-06-11 )
MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKIVHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHYLLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVAQLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKVAEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSLKWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEIGFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG
Atome Classification :
(20 SA)
.........----10........20........30........40...-.....50........60........70.--..--.....80........90........100.......110.......120.......130....--------------------------...140.......150...-----------------------------....160.......170.......180.......190.......200.........210.......220------.---------------------......230......--.240------------........250.......260.......---270.......280.......290.......300.......310----------------.......320.-------......330.......340.......350.......360......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
K
I
L
LADD----
E
R
I
I
LDGM
A
G
I
I
E
W
E
S
L
G
A
S
L
I
GKAQN
G
H
E
A
Y
E
K
I
-
V
HKQP
H
I
V
I
T
DVKMPGM
D
G
L
E
L
I
K
K
V
SA--VS--P
S
V
Q
F
I
V
L
SGFG
E
F
E
Y
A
K
E
A
M
K
Y
G
V
K
H
Y
LLKPC
N
E
Q
Q
I
I
S
S
L
E
E
I
I
A
E
L
K
R
Q
D
V
H
K
K
K
T
A
H
L
--------------------------
K
H
E
L
D
H
I
R
S
F
A
A
D
Q
Y
L
E
G
L
-----------------------------
I
A
G
V
A
QLSPPPSLAG
K
K
I
R
L
L
I
L
KGEQS
I
D
A
A
A
R
E
A
L
G
S
A
L
T
A
V
C--SSG
E
W
T
V
L
A
VEE
N
A
A
E
K
V
A
E
V
F
------A---------------------D
R
K
M
A
I
S
QAG
E
L
R
H
A
--
G
Q
L
-------------
F
R
D
T
A
EASGDL
H
G
S
A
V
I
S
K
M
I
R
L
I
A
D
EL---GNPN
L
S
L
K
W
AAK
D
M
L
F
M
N
P
D
Y
L
G
K
L
F
K
Q
E
T
G
E
K
F
S
Q
Y
V
T
R
V
R
L
----------------
E
H
A
M
K
Q
M
K
I
RR-------DV
S
V
S
E
I
A
E
E
IGFGDN
P
K
Y
F
S
L
V
F
K
K
YTGL
T
P
S
E
F
R
R
KQGGASAG
56
Fugue
80.04
17%
-126
- C2 -
1NY5
8
?
A:
[1-384]
-
M
N
V
L
V
I
E
D
----
D
K
V
F
R
G
L
L
E
E
Y
L
S
M
K
G
I
---
K
V
E
S
A
E
R
G
K
E
A
Y
K
L
L
-
S
E
K
H
F
N
V
V
L
L
D
L
L
L
P
D
V
N
G
L
E
I
L
K
W
I
K
E
--
R
S
--
P
E
T
E
V
I
V
I
T
G
H
G
T
I
K
T
A
V
E
A
M
K
M
G
A
Y
D
F
L
T
K
P
C
M
L
E
E
I
E
L
T
I
N
K
A
I
E
H
R
K
L
R
K
E
N
E
L
L
R
R
E
K
--------------------------
D
L
K
E
E
E
Y
V
F
--
E
S
P
K
M
K
E
I
-----------------------------
L
E
K
I
K
K
I
S
C
A
E
C
P
-------
V
L
I
T
G
E
S
G
V
G
---
K
E
V
V
A
R
L
I
H
K
L
S
DR
S
K
E
P
F
V
A
L
N
V
A
S
I
P
R
D
I
F
E
A
E
L
FGYEKG
A
---------------------
F
T
G
A
V
S
S
K
E
G
F
F
E
L
A
DG
G
T
L
-------------
F
L
D
E
I
G
E
L
S
----
L
E
A
Q
A
K
L
L
R
V
I
E
S
G
K
F
Y
R
L
G
G
R
K
E
I
E
V
N
V
R
I
L
A
A
T
N
R
N
I
K
E
L
V
K
E
G
K
F
R
E
D
L
Y
Y
R
L
G
V
I
E
I
E
I
P
P
LRERKED
I
I
P
L
A
N
H
F
L
K
K
F
S
R
K
Y
AKEVEGF
T
K
S
A
Q
E
L
L
L
S
Y
P
W
Y
G
N
V
R
E
L
K
N
V
I
E
R
A
V
L
F
S
E
G
K
F
I
D
R
G
E
L
S
C
L
V
61
Fugue
73.78
14%
-82
- C2 -
1W25
4
PLED_CAUCN
A:
[1-454]
S
A
R
I
L
V
V
D
D
----
I
E
A
N
V
R
L
L
E
A
K
L
T
A
E
Y
Y
---
E
V
S
T
A
M
D
G
P
T
A
L
A
M
A
-
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
DP
T
T
--
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
RRMGVIAGAAARLDG
L
G
G
R
V
L
I
V
D
DN
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
V
I
E
SD
P
E
K
A
K
I
S
A
G
GPVD
L
V
I
V
N
AAAKNFD
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
A
L
E
I
G
V
N
D
I
L
S
R
P
--
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
R
K
R
Y
T
D
Y
------
L
R
N
NLDHSLELAVTDQLTGLHN
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
--
T
L
G
G
D
P
V
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
---
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
-
T
A
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
P
F
----------------
T
V
A
H
G
R
E
M
L
N
V
-------
T
I
S
I
G
-
V
S
A
T
A
G
E
G
D
T
P
E
A
L
L
K
R
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
A
A
H
9
PsiBlast_PDB
63.70
30%
-149
- C2 -
4QYW
-
CHEY_THEMA
A:
[4-118]
--
R
V
L
I
V
D
D
----
A
A
F
M
R
M
M
L
K
D
I
I
T
--
K
A
G
Y
E
V
A
G
E
A
T
N
G
R
E
A
V
E
K
Y
-
K
E
L
K
P
D
I
V
T
M
-
I
T
M
P
E
M
N
G
I
D
A
I
K
E
I
M
K
--
I
D
--
P
N
A
K
I
I
V
A
S
A
M
G
Q
Q
A
M
V
I
E
A
I
K
A
G
A
K
D
F
I
V
K
P
F
Q
P
S
R
V
V
E
A
L
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
63.65
31%
-140
- C2 -
3TMY
1
CHEY_THEMA
B:
[4-118]
--
R
V
L
I
V
D
D
----
A
A
F
M
R
M
M
L
K
D
I
I
T
--
K
A
G
Y
E
V
A
G
E
A
T
N
G
R
E
A
V
E
K
Y
-
K
E
L
K
P
D
I
V
T
M
D
I
T
M
P
E
M
N
G
I
D
A
I
K
E
I
M
K
--
I
D
--
P
N
A
K
I
I
V
C
S
A
M
G
Q
Q
A
M
V
I
E
A
I
K
A
G
A
K
D
F
I
V
K
P
F
Q
P
S
R
V
V
E
A
L
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
63.41
33%
-161
- C2 -
3CU5
-
?
A:
[3-122]
-
L
R
I
L
I
V
D
D
----
E
K
L
T
R
D
G
L
I
A
N
I
N
W
K
A
L
S
F
D
Q
I
D
Q
A
D
D
G
I
N
A
I
Q
I
A
-
L
K
H
P
P
N
V
L
L
T
D
V
R
M
P
R
M
D
G
I
E
L
V
D
N
I
L
K
--
L
Y
--
P
D
C
S
V
I
F
M
S
G
Y
S
D
K
E
Y
L
------
R
A
I
R
Y
V
E
K
P
I
D
P
S
E
I
M
D
A
L
K
Q
S
I
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.37
30%
-159
- C2 -
1L5Z
5
DCTD_RHIME
A:
[6-130]
---
V
F
L
I
D
D
----
D
R
D
L
R
K
A
M
Q
Q
T
L
E
L
A
G
F
T
V
S
S
F
A
S
A
T
---
E
A
L
A
G
L
-
S
A
D
F
A
G
I
V
I
S
D
I
R
M
P
G
M
D
G
L
A
L
F
R
K
I
L
A
--
L
D
--
P
D
L
P
M
I
L
V
T
G
H
G
D
I
P
M
A
V
Q
A
I
Q
D
G
A
Y
D
F
I
A
K
P
F
A
A
D
R
L
V
Q
S
A
R
R
--
A
E
K
K
R
R
L
V
M
E
N
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.23
31%
-133
- C2 -
4IGA
3
CHEY_THEMA
A:
[7-121]
--
R
V
L
I
V
D
D
----
A
A
F
M
R
M
M
L
K
D
I
I
T
--
K
A
G
Y
E
V
A
G
E
A
T
N
G
R
E
A
V
E
K
Y
-
K
E
L
K
P
D
I
V
T
M
D
I
T
M
P
E
M
N
G
I
D
A
I
K
E
I
M
K
--
I
D
--
P
N
A
K
I
I
V
C
S
A
M
G
Q
Q
A
M
V
I
E
A
I
K
A
G
A
K
D
F
I
V
K
P
F
Q
P
S
R
V
V
E
A
L
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
63.02
31%
-139
- C2 -
3H1G
4
CHEY_HELPY
A:
[7-126]
--
K
L
L
V
V
D
D
S
S
T
M
R
R
I
I
K
N
T
L
S
------
R
L
G
Y
E
D
V
L
E
A
E
H
G
V
E
A
W
E
K
L
D
A
N
A
D
T
K
V
L
I
T
D
W
N
M
P
E
M
N
G
L
D
L
V
K
K
V
R
S
--
D
S
RF
K
E
I
P
I
I
M
I
T
A
E
G
G
K
A
E
V
I
T
A
L
K
A
G
V
N
N
Y
I
V
K
P
F
T
P
Q
V
L
K
E
K
L
E
V
V
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.90
31%
-150
- C2 -
1TMY
-
CHEY_THEMA
A:
[4-118]
--
R
V
L
I
V
D
D
----
A
A
F
M
R
M
M
L
K
D
I
I
T
--
K
A
G
Y
E
V
A
G
E
A
T
N
G
R
E
A
V
E
K
Y
-
K
E
L
K
P
D
I
V
T
M
D
I
T
M
P
E
M
N
G
I
D
A
I
K
E
I
M
K
--
I
D
--
P
N
A
K
I
I
V
C
S
A
M
G
Q
Q
A
M
V
I
E
A
I
K
A
G
A
K
D
F
I
V
K
P
F
Q
P
S
R
V
V
E
A
L
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
62.84
31%
-133
- C2 -
4TMY
1
CHEY_THEMA
B:
[4-118]
--
R
V
L
I
V
D
D
----
A
A
F
M
R
M
M
L
K
D
I
I
T
--
K
A
G
Y
E
V
A
G
E
A
T
N
G
R
E
A
V
E
K
Y
-
K
E
L
K
P
D
I
V
T
M
D
I
T
M
P
E
M
N
G
I
D
A
I
K
E
I
M
K
--
I
D
--
P
N
A
K
I
I
V
C
S
A
M
G
Q
Q
A
M
V
I
E
A
I
K
A
G
A
K
D
F
I
V
K
P
F
Q
P
S
R
V
V
E
A
L
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
62.53
31%
-134
- C2 -
3TMY
1
CHEY_THEMA
A:
[4-118]
--
R
V
L
I
V
D
D
----
A
A
F
M
R
M
M
L
K
D
I
I
T
--
K
A
G
Y
E
V
A
G
E
A
T
N
G
R
E
A
V
E
K
Y
-
K
E
L
K
P
D
I
V
T
M
D
I
T
M
P
E
M
N
G
I
D
A
I
K
E
I
M
K
--
I
D
--
P
N
A
K
I
I
V
C
S
A
M
G
Q
Q
A
M
V
I
E
A
I
K
A
G
A
K
D
F
I
V
K
P
F
Q
P
S
R
V
V
E
A
L
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
62.43
31%
-137
- C2 -
3GWG
4
CHEY_HELPY
A:
[7-126]
--
K
L
L
V
V
D
D
S
S
T
M
R
R
I
I
K
N
T
L
S
------
R
L
G
Y
E
D
V
L
E
A
E
H
G
V
E
A
W
E
K
L
D
A
N
A
D
T
K
V
L
I
T
D
W
N
M
P
E
M
N
G
L
D
L
V
K
K
V
R
S
--
D
S
RF
K
E
I
P
I
I
M
I
T
T
E
G
G
K
A
E
V
I
T
A
L
K
A
G
V
N
N
Y
I
V
K
P
F
T
P
Q
V
L
K
E
K
L
E
V
V
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
62.39
30%
-152
- C2 -
1L5Y
11
DCTD_RHIME
A:
[6-130]
---
V
F
L
I
D
D
----
D
R
D
L
R
K
A
M
Q
Q
T
L
E
L
A
G
F
T
V
S
S
F
A
S
A
T
---
E
A
L
A
G
L
-
S
A
D
F
A
G
I
V
I
S
D
I
R
M
P
G
M
D
G
L
A
L
F
R
K
I
L
A
--
L
D
--
P
D
L
P
M
I
L
V
T
G
H
G
D
I
P
M
A
V
Q
A
I
Q
D
G
A
Y
D
F
I
A
K
P
F
A
A
D
R
L
V
Q
S
A
R
R
--
A
E
K
K
R
R
L
V
M
E
N
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
62.32
31%
-140
- C2 -
3H1E
4
CHEY_HELPY
A:
[7-126]
--
K
L
L
V
V
D
D
S
S
T
M
R
R
I
I
K
N
T
L
S
------
R
L
G
Y
E
D
V
L
E
A
E
H
G
V
E
A
W
E
K
L
D
A
N
A
D
T
K
V
L
I
T
D
W
N
M
P
E
M
N
G
L
D
L
V
K
K
V
R
S
--
D
S
RF
K
E
I
P
I
I
M
I
T
T
E
G
G
K
A
E
V
I
T
A
L
K
A
G
V
N
N
Y
I
V
K
P
F
T
P
Q
V
L
K
E
K
L
E
V
V
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.10
33%
-160
- C2 -
3CU5
-
?
A:
[4-121]
--
R
I
L
I
V
D
D
----
E
K
L
T
R
D
G
L
I
A
N
I
N
W
K
A
L
S
F
D
Q
I
D
Q
A
D
D
G
I
N
A
I
Q
I
A
-
L
K
H
P
P
N
V
L
L
T
D
V
R
M
P
R
M
D
G
I
E
L
V
D
N
I
L
K
--
L
Y
--
P
D
C
S
V
I
F
M
S
G
Y
S
D
K
E
Y
L
------
R
A
I
R
Y
V
E
K
P
I
D
P
S
E
I
M
D
A
L
K
Q
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
61.69
31%
-128
- C2 -
4TMY
1
CHEY_THEMA
A:
[4-118]
--
R
V
L
I
V
D
D
----
A
A
F
M
R
M
M
L
K
D
I
I
T
--
K
A
G
Y
E
V
A
G
E
A
T
N
G
R
E
A
V
E
K
Y
-
K
E
L
K
P
D
I
V
T
M
D
I
T
M
P
E
M
N
G
I
D
A
I
K
E
I
M
K
--
I
D
--
P
N
A
K
I
I
V
C
S
A
M
G
Q
Q
A
M
V
I
E
A
I
K
A
G
A
K
D
F
I
V
K
P
F
Q
P
S
R
V
V
E
A
L
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.50
31%
-153
- C2 -
2TMY
-
CHEY_THEMA
A:
[4-118]
--
R
V
L
I
V
D
D
----
A
A
F
M
R
M
M
L
K
D
I
I
T
--
K
A
G
Y
E
V
A
G
E
A
T
N
G
R
E
A
V
E
K
Y
-
K
E
L
K
P
D
I
V
T
M
D
I
T
M
P
E
M
N
G
I
D
A
I
K
E
I
M
K
--
I
D
--
P
N
A
K
I
I
V
C
S
A
M
G
Q
Q
A
M
V
I
E
A
I
K
A
G
A
K
D
F
I
V
K
P
F
Q
P
S
R
V
V
E
A
L
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.83
31%
-158
- C- -
1U0S
-
CHEY_THEMA
Y:
[4-118]
--
R
V
L
I
V
D
D
----
A
A
F
M
R
M
M
L
K
D
I
I
T
--
K
A
G
Y
E
V
A
G
E
A
T
N
G
R
E
A
V
E
K
Y
-
K
E
L
K
P
D
I
V
T
M
D
I
T
M
P
E
M
N
G
I
D
A
I
K
E
I
M
K
--
I
D
--
P
N
A
K
I
I
V
C
S
A
M
G
Q
Q
A
M
V
I
E
A
I
K
A
G
A
K
D
F
I
V
K
P
F
Q
P
S
R
V
V
E
A
L
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.52
27%
-133
- C2 -
4LE2
3
DESR_BACSU
A:
[5-121]
M
I
S
I
F
I
A
E
D
----
Q
Q
M
L
L
G
A
L
G
S
L
L
N
L
E
D
-
D
M
E
V
V
G
K
G
T
T
G
Q
D
A
V
D
F
V
-
K
K
R
Q
P
D
V
C
I
M
D
I
E
M
P
G
K
T
G
L
E
A
A
E
E
L
K
----
D
--
T
G
C
K
I
I
I
L
T
T
F
A
R
P
G
Y
F
Q
R
A
I
K
A
G
V
K
G
Y
L
L
K
D
S
P
S
E
E
L
A
N
A
I
R
S
V
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
59.68
30%
-161
- C- -
1QKK
-
DCTD_RHIME
A:
[7-131]
---
V
F
L
I
D
D
----
D
R
D
L
R
K
A
M
Q
Q
T
L
E
L
A
G
F
T
V
S
S
F
A
S
A
T
---
E
A
L
A
G
L
-
S
A
D
F
A
G
I
V
I
S
D
I
R
M
P
G
M
D
G
L
A
L
F
R
K
I
L
A
--
L
D
--
P
D
L
P
M
I
L
V
T
G
H
G
D
I
P
M
A
V
Q
A
I
Q
D
G
A
Y
D
F
I
A
K
P
F
A
A
D
R
L
V
Q
S
A
R
R
--
A
E
E
K
R
R
L
V
M
E
N
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------