@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu07060: (2016-06-11 )
MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYRDGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAKPEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAYKLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGTAYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSVADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDATKPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLFTSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQPAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDPVYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-------------.........210.......220.......-----230.......240.......---250.......260..-.....270.......280-.......290..-------------------------.....300.......310.......320...---.--...330.......340.....-------..350------.......---..360..----------..-------------...370......---------.380......-----.390.......400.......410.......420.......430.......440.....-..450........460--..---.......470---..-.....480.......490--......---...500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKP
K
K
R
Q
M
E
Y
L
T
RG
L
I
A
V
QTEQ
G
V
F
V
S
W
R
F
LGTDHE
T
T
A
F
H
L
Y
RDGKRITRDPIAESTNFLDQNGTAD
S
V
Y
Q
V
A
AVNKG
R
E
E
K
L
S
K
K
A
R
V
W
Q
E
NVLEVPLAKPEGGVTPDGK
P
Y
T
YSANDASVGDIDGDG
E
Y
E
M
I
L
K
WDPSNSKDNAHDGYT
G
E
V
L
I
D
A
Y
KLD
G
T
F
L
W
R
I
NLGRNIRAGA
H
Y
T
Q
F
M
V
Y
DLDGDG
K
A
E
I
A
M
---------------
K
TADGTTDGKG
H
I
IGDEQADFRNEQGRIL-----SGP
E
Y
L
T
V
F
KGETG
E
A
L
T
T
V
---EYEPPRGKLEDWGDG-Y
G
N
R
M
D
R
F
L
AGTAYLDGE-RP
S
L
V
M
A
RG
Y
Y
T
-------------------------
R
T
V
L
V
A
Y
DFRNG
R
L
K
K
R
W
V
FDSNQPGHEAYA---G--QGNH
S
L
S
V
A
DVDGDGKD
E
I
I
Y
-------
G
A
M
--------
A
VDHDGT---GLYSTGL----------GH-------------GD
A
M
H
VGDLDPS---------RKG
L
E
V
F
Q
VH-----EDATKPY
G
L
S
LRDAGTG
E
I
L
W
G
VHAGTDVGRGMAAHIDPSYKG
S
L
V
W
GIDPPGNDGMSY-GLFT-SKGEKISDK----AP---SSA
N
F
A
I
W
W
D
---
G
D
-
L
V
R
E
L
L
DHDWDGTIGR----PKIEKW---DAEN
G
C
L
K
T
I
FQPAGVLSNNGTKGN
P
V
L
Q
ANL
F
G
D
W
R
E
E
V
I
W
RTEDS
S
A
L
R
I
Y
T
T
T
H
L
T
R
H
C
F
Y
T
L
MHD
P
V
Y
RLG
I
A
WQNTAYNQPPHT
S
F
Y
LGTGMKKPPK
P
A
L
Y
I
AGSKAEAPL-----------------------
1
PsiBlast_PDB
74.44
100%
-40
- C7 -
2ZUY
9
YESX_BACSU
A:
[3-606]
--
P
K
K
R
Q
M
E
Y
L
T
R
G
L
I
A
V
Q
T
E
Q
G
V
F
V
S
W
R
F
L
G
T
D
H
E
T
T
A
F
H
L
Y
R
D
G
K
R
I
T
R
D
P
I
A
E
S
T
N
F
L
D
Q
N
G
T
A
D
S
V
Y
Q
V
A
A
V
N
K
G
R
E
E
K
L
S
K
K
A
R
V
W
Q
E
N
V
L
E
V
P
L
A
K
P
E
G
G
V
T
P
D
G
K
P
Y
T
Y
S
A
N
D
A
S
V
G
D
I
D
G
D
G
E
Y
E
M
I
L
K
W
D
P
S
N
S
K
D
N
A
H
D
G
Y
T
G
E
V
L
I
D
A
Y
K
L
D
G
T
F
L
W
R
I
N
L
G
R
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
I
A
M
---------------
K
T
A
D
G
T
T
D
G
K
G
H
I
I
G
D
E
Q
A
D
F
R
N
E
Q
G
R
I
L
-----
S
G
P
E
Y
L
T
V
F
K
G
E
T
G
E
A
L
T
T
V
---
E
Y
E
P
P
R
G
K
L
E
D
W
G
D
G
-
Y
G
N
R
M
D
R
F
L
A
G
T
A
Y
L
D
G
E
-
R
P
S
L
V
M
A
R
G
Y
Y
T
-------------------------
R
T
V
L
V
A
Y
D
F
R
N
G
R
L
K
K
R
W
V
F
D
S
N
Q
P
G
H
E
A
Y
A
---
G
--
Q
G
N
H
S
L
S
V
A
D
V
D
G
D
G
K
D
E
I
I
Y
-------
G
A
M
--------
A
V
D
H
D
G
T
---
G
L
Y
S
T
G
L
----------
G
H
-------------
G
D
A
M
H
V
G
D
L
D
P
S
---------
R
K
G
L
E
V
F
Q
V
H
-----
E
D
A
T
K
P
Y
G
L
S
L
R
D
A
G
T
G
E
I
L
W
G
V
H
A
G
T
D
V
G
R
G
M
A
A
H
I
D
P
S
Y
K
G
S
L
V
W
G
I
D
P
P
G
N
D
G
M
S
Y
-
G
L
F
T
-
S
K
G
E
K
I
S
D
K
----
A
P
---
S
S
A
N
F
A
I
W
W
D
---
G
D
-
L
V
R
E
L
L
D
H
D
W
D
G
T
I
G
R
----
P
K
I
E
K
W
---
D
A
E
N
G
C
L
K
T
I
F
Q
P
A
G
V
L
S
N
N
G
T
K
G
N
P
V
L
Q
A
N
L
F
G
D
W
R
E
E
V
I
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
H
L
T
R
H
C
F
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
T
A
Y
N
Q
P
P
H
T
S
F
Y
L
G
T
G
M
K
K
P
P
K
P
A
L
Y
I
A
G
S
-----------------------------
31
HHSearch
73.85
99%
-40
- C7 -
2ZUY
9
YESX_BACSU
A:
[3-606]
--
P
K
K
R
Q
M
E
Y
L
T
R
G
L
I
A
V
Q
T
E
Q
G
V
F
V
S
W
R
F
L
G
T
D
H
E
T
T
A
F
H
L
Y
R
D
G
K
R
I
T
R
D
P
I
A
E
S
T
N
F
L
D
Q
N
G
T
A
D
S
V
Y
Q
V
A
A
V
N
K
G
R
E
E
K
L
S
K
K
A
R
V
W
Q
E
N
V
L
E
V
P
L
A
K
P
E
G
G
V
T
P
D
G
K
P
Y
T
Y
S
A
N
D
A
S
V
G
D
I
D
G
D
G
E
Y
E
M
I
L
K
W
D
P
S
N
S
K
D
N
A
H
D
G
Y
T
G
E
V
L
I
D
A
Y
K
L
D
G
T
F
L
W
R
I
N
L
G
R
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
I
A
M
---------------
K
T
A
D
G
T
T
D
G
K
G
H
I
I
G
D
E
Q
A
D
F
R
N
E
Q
G
R
I
L
-----
S
G
P
E
Y
L
T
V
F
K
G
E
T
G
E
A
L
T
T
V
---
E
Y
E
P
P
R
G
K
L
E
D
W
G
D
G
-
Y
G
N
R
M
D
R
F
L
A
G
T
A
Y
L
D
G
E
-
R
P
S
L
V
M
A
R
G
Y
Y
T
-------------------------
R
T
V
L
V
A
Y
D
F
R
N
G
R
L
K
K
R
W
V
F
D
S
N
Q
P
G
H
E
A
Y
A
---
G
--
Q
G
N
H
S
L
S
V
A
D
V
D
G
D
G
K
D
E
I
I
Y
-------
G
A
M
--------
A
V
D
H
D
G
T
---
G
L
Y
S
T
G
L
----------
G
H
-------------
G
D
A
M
H
V
G
D
L
D
P
S
---------
R
K
G
L
E
V
F
Q
V
H
-----
E
D
A
T
K
P
Y
G
L
S
L
R
D
A
G
T
G
E
I
L
W
G
V
H
A
G
T
D
V
G
R
G
M
A
A
H
I
D
P
S
Y
K
G
S
L
V
W
G
I
D
P
P
G
N
-
D
G
M
S
Y
G
L
F
T
-
S
K
G
E
K
I
S
D
K
----
A
P
---
S
S
A
N
F
A
I
W
W
D
---
G
D
-
L
V
R
E
L
L
D
H
D
W
D
G
T
I
G
R
----
P
K
I
E
K
W
---
D
A
E
N
G
C
L
K
T
I
F
Q
P
A
G
V
L
S
N
N
G
T
K
G
N
P
V
L
Q
A
N
L
F
G
D
W
R
E
E
V
I
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
H
L
T
R
H
C
F
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
T
A
Y
N
Q
P
P
H
T
S
F
Y
L
G
T
G
M
K
K
P
P
K
P
A
L
Y
I
A
G
S
-----------------------------
32
HHSearch
71.63
68%
-32
* C7 *
2ZUX
15
YESW_BACSU
A:
[2-583]
----
A
R
Q
M
E
A
L
N
R
G
L
V
A
V
K
T
D
G
G
I
F
V
S
W
R
F
L
G
T
E
N
A
S
V
L
F
N
V
Y
R
D
G
Q
K
L
N
A
A
P
V
K
-
T
T
N
Y
V
D
K
N
G
S
A
G
S
T
Y
T
V
R
A
V
V
N
G
T
E
Q
P
A
S
E
K
A
S
V
W
A
Q
P
Y
H
S
V
P
L
D
K
P
A
G
G
T
T
P
K
G
E
S
Y
T
Y
S
A
N
D
A
S
V
G
D
V
D
G
D
G
Q
Y
E
L
I
L
K
W
D
P
S
N
S
K
D
N
S
Q
D
G
Y
T
G
D
V
L
I
D
A
Y
K
L
D
G
T
K
L
W
R
I
N
L
G
K
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
V
A
M
---------------
K
T
A
D
G
T
K
D
G
T
G
K
V
I
G
N
A
N
A
D
Y
R
N
E
Q
G
R
V
L
-----
S
G
P
E
Y
L
T
V
F
Q
G
S
T
G
K
E
L
V
T
A
---
N
F
E
P
A
R
G
N
V
S
D
W
G
D
S
-
Y
G
N
R
V
D
R
F
L
A
G
I
A
Y
L
D
G
Q
-
R
P
S
L
I
M
T
R
G
Y
Y
A
-------------------------
K
T
M
L
V
A
Y
N
F
R
D
G
K
L
S
K
L
W
T
L
D
S
S
K
S
G
N
E
A
F
A
---
G
--
Q
G
N
H
N
L
S
I
A
D
V
D
G
D
G
K
D
E
I
I
F
-------
G
S
M
--------
A
V
D
H
D
G
K
---
G
M
Y
S
T
G
L
----------
G
H
-------------
G
D
A
L
H
T
G
D
L
D
P
G
---------
R
P
G
L
E
V
F
Q
V
H
-----
E
D
K
N
A
K
Y
G
L
S
F
R
D
A
A
T
G
K
I
L
W
G
V
Y
A
G
K
D
V
G
R
G
M
A
A
D
I
D
P
R
Y
P
G
Q
E
V
W
A
N
G
----------
S
L
Y
S
-
A
K
G
V
K
I
G
S
G
----
V
P
---
S
S
T
N
F
G
I
W
W
D
---
G
D
-
L
L
R
E
Q
L
D
S
------------
N
R
I
D
K
W
---
D
Y
Q
N
G
V
S
K
N
M
L
T
A
S
G
A
A
A
N
N
G
T
K
A
T
P
T
L
Q
A
D
L
L
G
D
W
R
E
E
V
V
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
I
P
T
E
H
R
L
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
I
A
Y
N
Q
P
P
H
T
S
F
F
L
G
D
G
M
A
E
Q
P
K
P
N
M
Y
T
P
-------------------------------
2
PsiBlast_PDB
71.39
68%
-30
- C7 -
4CAG
11
?
A:
[7-588]
---
Q
A
R
Q
M
E
S
L
N
R
G
L
V
A
V
K
T
G
N
G
V
F
V
S
W
R
L
L
G
T
E
P
S
S
V
S
F
N
V
Y
R
N
G
K
K
L
N
G
S
P
I
T
S
S
T
N
Y
Q
D
A
G
G
D
L
N
A
V
Y
Q
V
R
A
V
L
N
G
R
E
Q
A
P
S
E
S
V
G
V
L
N
K
Q
Y
K
S
V
P
L
Q
K
P
A
G
G
K
T
P
D
G
V
S
Y
T
Y
S
A
N
D
A
S
V
G
D
L
D
G
D
G
Q
Y
E
I
I
L
K
W
D
P
S
N
S
K
D
N
S
Q
D
G
Y
T
G
D
V
L
I
D
A
Y
K
L
D
G
T
M
M
W
R
I
N
L
G
K
N
I
R
A
G
A
H
Y
T
Q
F
L
V
Y
D
F
D
G
D
G
K
A
E
I
A
M
---------------
K
T
A
D
G
T
K
D
G
K
G
K
V
I
G
N
A
N
A
D
Y
R
N
A
Q
G
R
I
L
-----
S
G
P
E
Y
L
T
V
F
K
G
D
T
G
A
E
L
T
T
V
---
N
Y
E
P
A
R
G
N
V
A
D
W
G
D
S
-
Y
G
N
R
V
D
R
F
L
A
G
V
A
Y
L
D
G
E
-
R
P
S
F
V
M
A
R
G
Y
Y
T
-------------------------
R
T
V
L
V
A
Y
N
F
R
G
G
K
L
T
K
L
W
T
F
D
S
D
A
P
G
N
G
A
Y
A
---
G
--
Q
G
N
H
S
L
S
V
A
D
V
D
G
D
G
K
D
E
I
I
Y
-------
G
A
M
--------
A
V
D
H
D
G
K
---
G
L
Y
S
T
G
W
----------
G
H
-------------
G
D
A
M
H
T
G
N
L
D
P
S
---------
R
P
G
L
E
V
F
Q
V
H
-----
E
N
S
N
S
P
Y
G
L
S
F
R
D
A
K
T
G
K
I
I
W
G
V
H
A
G
K
D
V
G
R
G
M
A
A
D
I
D
P
R
Y
E
G
A
E
V
W
A
---------
N
G
-
S
L
Y
T
-
A
K
G
V
K
I
G
N
T
----
L
P
---
S
S
T
N
F
G
I
W
W
D
---
G
D
-
L
Q
R
E
L
L
D
S
N
------------
R
I
D
K
W
---
D
Y
Q
N
S
R
T
V
N
L
L
T
A
S
G
A
S
A
N
N
G
T
K
A
T
P
S
L
Q
A
D
I
L
G
D
W
R
E
E
V
V
W
R
A
E
D
S
S
E
L
R
I
Y
T
T
T
D
V
T
E
H
R
M
Y
T
L
M
H
D
A
V
Y
R
L
G
I
A
W
Q
N
V
G
Y
N
Q
P
P
H
T
G
F
Y
L
G
E
G
M
Q
T
P
E
K
P
N
I
Y
---------------------------------
5
PsiBlast_PDB
71.32
67%
-32
- C7 -
2ZUX
15
YESW_BACSU
A:
[3-581]
-----
R
Q
M
E
A
L
N
R
G
L
V
A
V
K
T
D
G
G
I
F
V
S
W
R
F
L
G
T
E
N
A
S
V
L
F
N
V
Y
R
D
G
Q
K
L
N
A
A
P
V
-
K
T
T
N
Y
V
D
K
N
G
S
A
G
S
T
Y
T
V
R
A
V
V
N
G
T
E
Q
P
A
S
E
K
A
S
V
W
A
Q
P
Y
H
S
V
P
L
D
K
P
A
G
G
T
T
P
K
G
E
S
Y
T
Y
S
A
N
D
A
S
V
G
D
V
D
G
D
G
Q
Y
E
L
I
L
K
W
D
P
S
N
S
K
D
N
S
Q
D
G
Y
T
G
D
V
L
I
D
A
Y
K
L
D
G
T
K
L
W
R
I
N
L
G
K
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
V
A
M
---------------
K
T
A
D
G
T
K
D
G
T
G
K
V
I
G
N
A
N
A
D
Y
R
N
E
Q
G
R
V
L
-----
S
G
P
E
Y
L
T
V
F
Q
G
S
T
G
K
E
L
V
T
A
---
N
F
E
P
A
R
G
N
V
S
D
W
G
D
S
-
Y
G
N
R
V
D
R
F
L
A
G
I
A
Y
L
D
G
Q
-
R
P
S
L
I
M
T
R
G
Y
Y
A
-------------------------
K
T
M
L
V
A
Y
N
F
R
D
G
K
L
S
K
L
W
T
L
D
S
S
K
S
G
N
E
A
F
A
---
G
--
Q
G
N
H
N
L
S
I
A
D
V
D
G
D
G
K
D
E
I
I
F
-------
G
S
M
--------
A
V
D
H
D
G
K
---
G
M
Y
S
T
G
L
----------
G
H
-------------
G
D
A
L
H
T
G
D
L
D
P
G
---------
R
P
G
L
E
V
F
Q
V
H
-----
E
D
K
N
A
K
Y
G
L
S
F
R
D
A
A
T
G
K
I
L
W
G
V
Y
A
G
K
D
V
G
R
G
M
A
A
D
I
D
P
R
Y
P
G
Q
E
V
W
A
---------
N
G
-
S
L
Y
S
-
A
K
G
V
K
I
G
S
G
----
V
P
---
S
S
T
N
F
G
I
W
W
D
---
G
D
-
L
L
R
E
Q
L
D
S
N
------------
R
I
D
K
W
---
D
Y
Q
N
G
V
S
K
N
M
L
T
A
S
G
A
A
A
N
N
G
T
K
A
T
P
T
L
Q
A
D
L
L
G
D
W
R
E
E
V
V
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
I
P
T
E
H
R
L
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
I
A
Y
N
Q
P
P
H
T
S
F
F
L
G
D
G
M
A
E
Q
P
K
P
N
M
Y
---------------------------------
18
PsiBlast_CBE
71.23
67%
-31
- C7 -
2ZUX
12
YESW_BACSU
B:
[3-581]
-----
R
Q
M
E
A
L
N
R
G
L
V
A
V
K
T
D
G
G
I
F
V
S
W
R
F
L
G
T
E
N
A
S
V
L
F
N
V
Y
R
D
G
Q
K
L
N
A
A
P
V
-
K
T
T
N
Y
V
D
K
N
G
S
A
G
S
T
Y
T
V
R
A
V
V
N
G
T
E
Q
P
A
S
E
K
A
S
V
W
A
Q
P
Y
H
S
V
P
L
D
K
P
A
G
G
T
T
P
K
G
E
S
Y
T
Y
S
A
N
D
A
S
V
G
D
V
D
G
D
G
Q
Y
E
L
I
L
K
W
D
P
S
N
S
K
D
N
S
Q
D
G
Y
T
G
D
V
L
I
D
A
Y
K
L
D
G
T
K
L
W
R
I
N
L
G
K
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
V
A
M
---------------
K
T
A
D
G
T
K
D
G
T
G
K
V
I
G
N
A
N
A
D
Y
R
N
E
Q
G
R
V
L
-----
S
G
P
E
Y
L
T
V
F
Q
G
S
T
G
K
E
L
V
T
A
---
N
F
E
P
A
R
G
N
V
S
D
W
G
D
S
-
Y
G
N
R
V
D
R
F
L
A
G
I
A
Y
L
D
G
Q
-
R
P
S
L
I
M
T
R
G
Y
Y
A
-------------------------
K
T
M
L
V
A
Y
N
F
R
D
G
K
L
S
K
L
W
T
L
D
S
S
K
S
G
N
E
A
F
A
---
G
--
Q
G
N
H
N
L
S
I
A
D
V
D
G
D
G
K
D
E
I
I
F
-------
G
S
M
--------
A
V
D
H
D
G
K
---
G
M
Y
S
T
G
L
----------
G
H
-------------
G
D
A
L
H
T
G
D
L
D
P
G
---------
R
P
G
L
E
V
F
Q
V
H
-----
E
D
K
N
A
K
Y
G
L
S
F
R
D
A
A
T
G
K
I
L
W
G
V
Y
A
G
K
D
V
G
R
G
M
A
A
D
I
D
P
R
Y
P
G
Q
E
V
W
A
---------
N
G
-
S
L
Y
S
-
A
K
G
V
K
I
G
S
G
----
V
P
---
S
S
T
N
F
G
I
W
W
D
---
G
D
-
L
L
R
E
Q
L
D
S
N
------------
R
I
D
K
W
---
D
Y
Q
N
G
V
S
K
N
M
L
T
A
S
G
A
A
A
N
N
G
T
K
A
T
P
T
L
Q
A
D
L
L
G
D
W
R
E
E
V
V
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
I
P
T
E
H
R
L
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
I
A
Y
N
Q
P
P
H
T
S
F
F
L
G
D
G
M
A
E
Q
P
K
P
N
M
Y
---------------------------------
21
Fugue
71.21
68%
-32
- C7 -
2Z8R
14
YESW_BACSU
A:
[1-583]
---
A
A
R
Q
M
E
A
L
N
R
G
L
V
A
V
K
T
D
G
G
I
F
V
S
W
R
F
L
G
T
E
N
A
S
V
L
F
N
V
Y
R
D
G
Q
K
L
N
A
A
P
V
-
K
T
T
N
Y
V
D
K
N
G
S
A
G
S
T
Y
T
V
R
A
V
V
N
G
T
E
Q
P
A
S
E
K
A
S
V
W
A
Q
P
Y
H
S
V
P
L
D
K
P
A
G
G
T
T
P
K
G
E
S
Y
T
Y
S
A
N
D
A
S
V
G
D
V
D
G
D
G
Q
Y
E
L
I
L
K
W
D
P
S
N
S
K
D
N
S
Q
D
G
Y
T
G
D
V
L
I
D
A
Y
K
L
D
G
T
K
L
W
R
I
N
L
G
K
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
V
A
M
---------------
K
T
A
D
G
T
K
D
G
T
G
K
V
I
G
N
A
N
A
D
Y
R
N
E
Q
G
R
V
L
-----
S
G
P
E
Y
L
T
V
F
Q
G
S
T
G
K
E
L
V
T
A
---
N
F
E
P
A
R
G
N
V
S
D
W
G
D
S
-
Y
G
N
R
V
D
R
F
L
A
G
I
A
Y
L
D
G
Q
-
R
P
S
L
I
M
T
R
G
Y
Y
A
-------------------------
K
T
M
L
V
A
Y
N
F
R
D
G
K
L
S
K
L
W
T
L
D
S
S
K
S
G
N
E
A
F
A
---
G
--
Q
G
N
H
N
L
S
I
A
D
V
D
G
D
G
K
D
E
I
I
F
-------
G
S
M
--------
A
V
D
H
D
G
K
---
G
M
Y
S
T
G
L
----------
G
H
-------------
G
D
A
L
H
T
G
D
L
D
P
G
---------
R
P
G
L
E
V
F
Q
V
H
-----
E
D
K
N
A
K
Y
G
L
S
F
R
D
A
A
T
G
K
I
L
W
G
V
Y
A
G
K
D
V
G
R
G
M
A
A
D
I
D
P
R
Y
P
G
Q
E
V
W
A
N
G
----------
S
L
Y
S
-
A
K
G
V
K
I
G
S
G
----
V
P
---
S
S
T
N
F
G
I
W
W
D
---
G
D
-
L
L
R
E
Q
L
D
S
------------
N
R
I
D
K
W
---
D
Y
Q
N
G
V
S
K
N
M
L
T
A
S
G
A
A
A
N
N
G
T
K
A
T
P
T
L
Q
A
D
L
L
G
D
W
R
E
E
V
V
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
I
P
T
E
H
R
L
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
I
A
Y
N
Q
P
P
H
T
S
F
F
L
G
D
G
M
A
E
Q
P
K
P
N
M
Y
T
P
-------------------------------
20
PsiBlast_CBE
70.99
67%
-30
- C7 -
2Z8R
12
YESW_BACSU
B:
[3-581]
-----
R
Q
M
E
A
L
N
R
G
L
V
A
V
K
T
D
G
G
I
F
V
S
W
R
F
L
G
T
E
N
A
S
V
L
F
N
V
Y
R
D
G
Q
K
L
N
A
A
P
V
-
K
T
T
N
Y
V
D
K
N
G
S
A
G
S
T
Y
T
V
R
A
V
V
N
G
T
E
Q
P
A
S
E
K
A
S
V
W
A
Q
P
Y
H
S
V
P
L
D
K
P
A
G
G
T
T
P
K
G
E
S
Y
T
Y
S
A
N
D
A
S
V
G
D
V
D
G
D
G
Q
Y
E
L
I
L
K
W
D
P
S
N
S
K
D
N
S
Q
D
G
Y
T
G
D
V
L
I
D
A
Y
K
L
D
G
T
K
L
W
R
I
N
L
G
K
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
V
A
M
---------------
K
T
A
D
G
T
K
D
G
T
G
K
V
I
G
N
A
N
A
D
Y
R
N
E
Q
G
R
V
L
-----
S
G
P
E
Y
L
T
V
F
Q
G
S
T
G
K
E
L
V
T
A
---
N
F
E
P
A
R
G
N
V
S
D
W
G
D
S
-
Y
G
N
R
V
D
R
F
L
A
G
I
A
Y
L
D
G
Q
-
R
P
S
L
I
M
T
R
G
Y
Y
A
-------------------------
K
T
M
L
V
A
Y
N
F
R
D
G
K
L
S
K
L
W
T
L
D
S
S
K
S
G
N
E
A
F
A
---
G
--
Q
G
N
H
N
L
S
I
A
D
V
D
G
D
G
K
D
E
I
I
F
-------
G
S
M
--------
A
V
D
H
D
G
K
---
G
M
Y
S
T
G
L
----------
G
H
-------------
G
D
A
L
H
T
G
D
L
D
P
G
---------
R
P
G
L
E
V
F
Q
V
H
-----
E
D
K
N
A
K
Y
G
L
S
F
R
D
A
A
T
G
K
I
L
W
G
V
Y
A
G
K
D
V
G
R
G
M
A
A
D
I
D
P
R
Y
P
G
Q
E
V
W
A
---------
N
G
-
S
L
Y
S
-
A
K
G
V
K
I
G
S
G
----
V
P
---
S
S
T
N
F
G
I
W
W
D
---
G
D
-
L
L
R
E
Q
L
D
S
N
------------
R
I
D
K
W
---
D
Y
Q
N
G
V
S
K
N
M
L
T
A
S
G
A
A
A
N
N
G
T
K
A
T
P
T
L
Q
A
D
L
L
G
D
W
R
E
E
V
V
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
I
P
T
E
H
R
L
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
I
A
Y
N
Q
P
P
H
T
S
F
F
L
G
D
G
M
A
E
Q
P
K
P
N
M
Y
---------------------------------
3
PsiBlast_PDB
70.98
67%
-32
- C7 -
2Z8R
14
YESW_BACSU
A:
[3-581]
-----
R
Q
M
E
A
L
N
R
G
L
V
A
V
K
T
D
G
G
I
F
V
S
W
R
F
L
G
T
E
N
A
S
V
L
F
N
V
Y
R
D
G
Q
K
L
N
A
A
P
V
-
K
T
T
N
Y
V
D
K
N
G
S
A
G
S
T
Y
T
V
R
A
V
V
N
G
T
E
Q
P
A
S
E
K
A
S
V
W
A
Q
P
Y
H
S
V
P
L
D
K
P
A
G
G
T
T
P
K
G
E
S
Y
T
Y
S
A
N
D
A
S
V
G
D
V
D
G
D
G
Q
Y
E
L
I
L
K
W
D
P
S
N
S
K
D
N
S
Q
D
G
Y
T
G
D
V
L
I
D
A
Y
K
L
D
G
T
K
L
W
R
I
N
L
G
K
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
V
A
M
---------------
K
T
A
D
G
T
K
D
G
T
G
K
V
I
G
N
A
N
A
D
Y
R
N
E
Q
G
R
V
L
-----
S
G
P
E
Y
L
T
V
F
Q
G
S
T
G
K
E
L
V
T
A
---
N
F
E
P
A
R
G
N
V
S
D
W
G
D
S
-
Y
G
N
R
V
D
R
F
L
A
G
I
A
Y
L
D
G
Q
-
R
P
S
L
I
M
T
R
G
Y
Y
A
-------------------------
K
T
M
L
V
A
Y
N
F
R
D
G
K
L
S
K
L
W
T
L
D
S
S
K
S
G
N
E
A
F
A
---
G
--
Q
G
N
H
N
L
S
I
A
D
V
D
G
D
G
K
D
E
I
I
F
-------
G
S
M
--------
A
V
D
H
D
G
K
---
G
M
Y
S
T
G
L
----------
G
H
-------------
G
D
A
L
H
T
G
D
L
D
P
G
---------
R
P
G
L
E
V
F
Q
V
H
-----
E
D
K
N
A
K
Y
G
L
S
F
R
D
A
A
T
G
K
I
L
W
G
V
Y
A
G
K
D
V
G
R
G
M
A
A
D
I
D
P
R
Y
P
G
Q
E
V
W
A
---------
N
G
-
S
L
Y
S
-
A
K
G
V
K
I
G
S
G
----
V
P
---
S
S
T
N
F
G
I
W
W
D
---
G
D
-
L
L
R
E
Q
L
D
S
N
------------
R
I
D
K
W
---
D
Y
Q
N
G
V
S
K
N
M
L
T
A
S
G
A
A
A
N
N
G
T
K
A
T
P
T
L
Q
A
D
L
L
G
D
W
R
E
E
V
V
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
I
P
T
E
H
R
L
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
I
A
Y
N
Q
P
P
H
T
S
F
F
L
G
D
G
M
A
E
Q
P
K
P
N
M
Y
---------------------------------
19
PsiBlast_CBE
70.94
67%
-31
- C7 -
2Z8S
11
YESW_BACSU
B:
[3-581]
-----
R
Q
M
E
A
L
N
R
G
L
V
A
V
K
T
D
G
G
I
F
V
S
W
R
F
L
G
T
E
N
A
S
V
L
F
N
V
Y
R
D
G
Q
K
L
N
A
A
P
V
-
K
T
T
N
Y
V
D
K
N
G
S
A
G
S
T
Y
T
V
R
A
V
V
N
G
T
E
Q
P
A
S
E
K
A
S
V
W
A
Q
P
Y
H
S
V
P
L
D
K
P
A
G
G
T
T
P
K
G
E
S
Y
T
Y
S
A
N
D
A
S
V
G
D
V
D
G
D
G
Q
Y
E
L
I
L
K
W
D
P
S
N
S
K
D
N
S
Q
D
G
Y
T
G
D
V
L
I
D
A
Y
K
L
D
G
T
K
L
W
R
I
N
L
G
K
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
V
A
M
---------------
K
T
A
D
G
T
K
D
G
T
G
K
V
I
G
N
A
N
A
D
Y
R
N
E
Q
G
R
V
L
-----
S
G
P
E
Y
L
T
V
F
Q
G
S
T
G
K
E
L
V
T
A
---
N
F
E
P
A
R
G
N
V
S
D
W
G
D
S
-
Y
G
N
R
V
D
R
F
L
A
G
I
A
Y
L
D
G
Q
-
R
P
S
L
I
M
T
R
G
Y
Y
A
-------------------------
K
T
M
L
V
A
Y
N
F
R
D
G
K
L
S
K
L
W
T
L
D
S
S
K
S
G
N
E
A
F
A
---
G
--
Q
G
N
H
N
L
S
I
A
D
V
D
G
D
G
K
D
E
I
I
F
-------
G
S
M
--------
A
V
D
H
D
G
K
---
G
M
Y
S
T
G
L
----------
G
H
-------------
G
D
A
L
H
T
G
D
L
D
P
G
---------
R
P
G
L
E
V
F
Q
V
H
-----
E
D
K
N
A
K
Y
G
L
S
F
R
D
A
A
T
G
K
I
L
W
G
V
Y
A
G
K
D
V
G
R
G
M
A
A
D
I
D
P
R
Y
P
G
Q
E
V
W
A
---------
N
G
-
S
L
Y
S
-
A
K
G
V
K
I
G
S
G
----
V
P
---
S
S
T
N
F
G
I
W
W
D
---
G
D
-
L
L
R
E
Q
L
D
S
N
------------
R
I
D
K
W
---
D
Y
Q
N
G
V
S
K
N
M
L
T
A
S
G
A
A
A
N
N
G
T
K
A
T
P
T
L
Q
A
D
L
L
G
D
W
R
E
E
V
V
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
I
P
T
E
H
R
L
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
I
A
Y
N
Q
P
P
H
T
S
F
F
L
G
D
G
M
A
E
Q
P
K
P
N
M
Y
---------------------------------
4
PsiBlast_PDB
70.28
67%
-31
- C7 -
2Z8S
11
YESW_BACSU
A:
[3-581]
-----
R
Q
M
E
A
L
N
R
G
L
V
A
V
K
T
D
G
G
I
F
V
S
W
R
F
L
G
T
E
N
A
S
V
L
F
N
V
Y
R
D
G
Q
K
L
N
A
A
P
V
-
K
T
T
N
Y
V
D
K
N
G
S
A
G
S
T
Y
T
V
R
A
V
V
N
G
T
E
Q
P
A
S
E
K
A
S
V
W
A
Q
P
Y
H
S
V
P
L
D
K
P
A
G
G
T
T
P
K
G
E
S
Y
T
Y
S
A
N
D
A
S
V
G
D
V
D
G
D
G
Q
Y
E
L
I
L
K
W
D
P
S
N
S
K
D
N
S
Q
D
G
Y
T
G
D
V
L
I
D
A
Y
K
L
D
G
T
K
L
W
R
I
N
L
G
K
N
I
R
A
G
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
V
A
M
---------------
K
T
A
D
G
T
K
D
G
T
G
K
V
I
G
N
A
N
A
D
Y
R
N
E
Q
G
R
V
L
-----
S
G
P
E
Y
L
T
V
F
Q
G
S
T
G
K
E
L
V
T
A
---
N
F
E
P
A
R
G
N
V
S
D
W
G
D
S
-
Y
G
N
R
V
D
R
F
L
A
G
I
A
Y
L
D
G
Q
-
R
P
S
L
I
M
T
R
G
Y
Y
A
-------------------------
K
T
M
L
V
A
Y
N
F
R
D
G
K
L
S
K
L
W
T
L
D
S
S
K
S
G
N
E
A
F
A
---
G
--
Q
G
N
H
N
L
S
I
A
D
V
D
G
D
G
K
D
E
I
I
F
-------
G
S
M
--------
A
V
D
H
D
G
K
---
G
M
Y
S
T
G
L
----------
G
H
-------------
G
D
A
L
H
T
G
D
L
D
P
G
---------
R
P
G
L
E
V
F
Q
V
H
-----
E
D
K
N
A
K
Y
G
L
S
F
R
D
A
A
T
G
K
I
L
W
G
V
Y
A
G
K
D
V
G
R
G
M
A
A
D
I
D
P
R
Y
P
G
Q
E
V
W
A
---------
N
G
-
S
L
Y
S
-
A
K
G
V
K
I
G
S
G
----
V
P
---
S
S
T
N
F
G
I
W
W
D
---
G
D
-
L
L
R
E
Q
L
D
S
N
------------
R
I
D
K
W
---
D
Y
Q
N
G
V
S
K
N
M
L
T
A
S
G
A
A
A
N
N
G
T
K
A
T
P
T
L
Q
A
D
L
L
G
D
W
R
E
E
V
V
W
R
T
E
D
S
S
A
L
R
I
Y
T
T
T
I
P
T
E
H
R
L
Y
T
L
M
H
D
P
V
Y
R
L
G
I
A
W
Q
N
I
A
Y
N
Q
P
P
H
T
S
F
F
L
G
D
G
M
A
E
Q
P
K
P
N
M
Y
---------------------------------
15
PsiBlast_PDB
34.48
45%
-145
- C9 -
4A7Z
3
AUD_PHACH
A:
[337-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
V
V
C
A
D
I
D
G
D
G
E
D
E
F
L
V
-------
A
M
M
--------
G
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
32.60
45%
-151
* C9 *
4A7Y
1
AUD_PHACH
A:
[337-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
V
V
C
A
D
I
D
G
D
G
E
D
E
F
L
V
-------
A
M
M
--------
G
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
32.18
45%
-143
- C9 -
4A7K
2
AUD_PHACH
A:
[337-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
V
V
C
A
D
I
D
G
D
G
E
D
E
F
L
V
-------
A
M
M
--------
G
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
28.97
13%
-70
- C7 -
2BWR
10
?
A:
[1-401]
-----------------------------------------------------------------------------------------------------------------
S
V
V
V
I
S
Q
A
L
P
V
P
T
R
I
P
G
V
A
D
L
V
G
F
G
N
G
G
-----------
V
Y
I
I
R
N
S
L
L
I
Q
V
V
K
V
I
N
N
F
G
Y
D
A
G
G
W
R
V
E
K
H
V
R
L
L
A
D
T
T
G
D
N
Q
S
D
V
V
G
FGEN
G
V
W
I
S
T
N
NGNN
T
F
V
D
P
P
K
M
V
L
A
N
F
A
Y
A
A
G
G
W
R
V
E
K
H
I
R
F
M
A
DLRK
T
G
R
A
D
I
V
G
F
G
D
G
G
I
Y
I
S
R
N
N
GGG
Q
F
A
P
A
Q
L
A
L
N
N
F
G
Y
A
-
Q
G
W
R
L
D
R
H
L
R
F
L
A
D
V
T
G
D
-
G
L
L
D
V
V
G
F
G
--
E
-------------------------
N
Q
V
Y
I
A
R
N
S
G
N
G
T
F
Q
P
A
Q
A
V
V
N
N
F
C
I
G
A
G
G
W
---
T
--
I
S
A
H
P
R
V
V
A
D
L
T
G
D
R
K
A
D
I
L
G
FGVA---
G
V
Y
--------
T
S
L
N
N
G
N
---
G
T
F
G
A
V
N
----------
L
V
LKDFGVNSGWRVE
K
H
V
R
C
V
S
S
L
T
N
K
K
V
G
D
I
I
G
FG
D
A
G
V
Y
V
A
L
N
N
GNGTF
G
P
V
K
R
V
I
D
N
F
G
Y
N
Q
G
W
R
V
D
K
H
P
R
F
V
V
D
L
T
G
D
G
C
A
D
I
V
G
F
G
E
N
S
V
W
A
C
M
N
K
G
D
G
----
T
F
-
G
P
I
M
-
K
L
I
D
D
M
T
V
S
----
K
G
---
W
T
L
Q
K
T
V
R
Y
A
---
A
N
-
L
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
28.89
19%
-44
- C7 -
5CVL
9
WDR48_HUMAN
A:
[27-578]
--
R
R
K
V
Q
V
S
Y
V
I
R
D
E
V
E
K
Y
N
R
N
G
V
N
A
----
L
Q
L
D
P
A
L
--
N
R
L
F
T
A
G
R
--------------------
D
S
I
I
R
I
W
S
V
N
Q
H
K
Q
D
P
Y
I
A
S
M
E
H
H
T
D
W
V
N
D
I
V
L
C
C
-------
N
G
K
T
L
I
S
A
S
S
D
T
T
V
K
V
W
N
-------------------
A
H
K
G
F
C
M
S
T
L
--------------------
R
T
H
K
D
Y
V
K
A
L
A
Y
A
K
D
---
K
E
L
V
A
S
---------------
A
G
L
D
R
Q
---------------------------------
I
F
L
W
D
V
N
T
L
T
A
L
T
A
S
---
N
N
T
V
T
T
S
S
L
S
G
N
K
D
S
I
Y
S
L
A
M
N
Q
L
--
G
T
I
I
V
S
G
S
-
T
E
K
V
L
R
V
W
D
P
R
T
-------------------------
C
A
K
L
M
K
L
K
G
H
T
D
N
V
K
A
L
L
L
---
N
R
D
G
T
Q
C
L
S
---
G
--
S
S
D
G
T
I
R
L
W
S
L
-
G
Q
Q
R
C
I
A
T
Y
RVHDEGV
W
A
L
--------
Q
V
N
D
A
F
T
---
H
V
Y
S
G
G
---------------------------
R
D
R
K
I
Y
C
T
D
L
R
---------
N
P
D
I
R
V
L
I
C
E
-----
E
K
A
P
V
L
K
M
E
L
D
R
S
A
D
P
P
P
A
I
W
V
A
T
T
K
S
T
V
N
K
W
T
L
K
G
I
H
N
F
R
A
S
G
P
I
T
P
L
C
T
Q
P
D
Q
V
I
K
G
-
G
A
S
I
-
I
Q
C
H
I
L
N
D
K
R
H
I
L
T
K
---
D
T
N
N
N
V
A
Y
W
D
VLK
A
C
-
K
V
E
D
L
G
K
V
D
F
E
D
E
I
K
K
R
FKM
V
Y
V
P
N
W
F
S
V
D
L
K
T
G
M
L
T
I
T
L
D
E
S
D
C
F
A
-------
A
W
V
S
A
K
D
A
G
-------
F
S
S
P
D
G
S
D
P
K
L
N
L
G
G
L
L
L
Q
A
L
L
E
Y
W
P
R
T
H
V
N
P
M
D
K
G
--
N
G
Y
F
Q
V
P
P
H
T
P
V
I
F
G
E
A
G
G
R
T
L
F
R
L
L
C
R
D
S
G
G
E
T
E
S
M
L
L
N
E
T
VP
Q
W
V
I
D
I
TVDKNMPKFN
10
PsiBlast_PDB
28.56
37%
-188
- C8 -
1KUG
3
A:
[77-108]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
F
G
D
W
R
E
R
V
L
L
K
K
K
N
H
D
H
A
Q
L
L
T
D
T
N
F
A
R
N
------------------------------------------------------------------------------
33
HHSearch
27.06
17%
-34
- C7 -
2ZUX
13
YESW_BACSU
A:
[115-470]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
A
S
V
G
D
V
D
G
D
G
Q
Y
E
L
I
L
---------------
K
W
D
P
S
N
S
-----------
K
D
N
-
S
Q
D
G
--
Y
-----
T
G
D
V
L
I
D
A
Y
K
L
D
-
G
T
K
L
W
R
I
---
N
L
G
K
N
I
R
---------
A
G
--
A
H
Y
T
Q
F
M
V
Y
D
L
D
G
D
G
K
A
E
V
A
M
K
T
A
D
G
T
KDGTGKVIGNANADYRNEQGRVLS
G
P
E
Y
L
T
V
F
Q
G
S
T
G
K
E
L
V
T
A
N
F
E
P
A
R
G
N
V
S
D
W
G
DSY
G
NR
V
D
R
F
L
A
G
I
A
Y
L
D
G
Q
-
R
P
S
L
I
M
-------
T
R
G
YY
A
K
T
M
L
V
A
Y
N
F
R
D
G
K
L
S
K
L
W
T
L
D
S
SKSGNEAFAG
Q
G
-------------
N
H
N
L
S
I
A
D
V
D
G
D
---------
G
K
-
D
E
I
I
F
G
S
--------------
M
A
V
D
H
-
D
G
K
G
M
Y
S
T
G
L
G
-
H
G
D
A
L
H
T
G
D
L
D
P
G
R
P
G
L
E
V
F
Q
V
H
E
D
K
N
A
K
Y
G
L
-
S
F
R
D
A
A
T
G
K
I
L
W
G
V
----
Y
A
GKD
V
G
R
G
M
A
A
D
I
D
---
P
R
Y
P
G
Q
E
V
W
A
N
G
------------
S
L
--
Y
---
S
A
K
-
G
--
V
K
I
G
S
G
--------
V
P
S
S
T
N
F
G
I
W
W
D
G
D
L
L
R
E
Q
L
D
S
N
-----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
26.55
37%
-175
- C8 -
1KUI
2
A:
[77-108]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
F
G
D
W
R
E
R
V
L
L
K
K
K
N
H
D
H
A
Q
L
L
T
D
T
N
F
A
R
N
------------------------------------------------------------------------------
9
PsiBlast_PDB
26.51
37%
-177
- C8 -
1KUK
2
A:
[77-108]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
F
G
D
W
R
E
R
V
L
L
K
K
K
N
H
D
H
A
Q
L
L
T
D
T
N
F
A
R
N
------------------------------------------------------------------------------