@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu07250: (2016-06-11 )
MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQIHTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAHNILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGFNYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLVDSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLLSFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAFSLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHAYKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHISVQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVARELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIKPGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQLDEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENRELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTLSASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSAEGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQASITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMVGPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTVHTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQAVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI
Atome Classification :
(83 SA)
.........10........------20........30........40........--50........60........70-----.........80........90........100.......110.......120.......130.......140--.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-.......340.......350.......360.......370.......380.......390.......400.......410.......420......---.430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKETSPIPQPKTFGPLGNL------PLIDKDKP
T
L
S
L
I
K
L
AEEQG
P
I
F
Q
I
HTPAG--
T
T
I
V
VS
G
H
E
L
V
K
E
V
C
D
E
E
R
F
D
------
K
S
I
E
G
A
L
E
K
V
R
AFSGDG
L
F
T
SWTHEPNW
R
K
A
H
NILM
P
T
F
S
Q
R
A
M
K
D
Y
H
E
K
M
V
D
I
A
V
Q
L
I
Q
K
W
ARLNPNEAVD--VPGD
M
T
R
L
T
L
D
TIGLCGFNYRFN
S
Y
YRETP
H
P
F
I
N
S
M
V
R
A
L
D
E
A
M
H
Q
M
Q
RL
D
V
Q
D
K
L
M
V
R
T
K
R
Q
F
R
Y
D
I
Q
T
M
F
S
L
V
D
S
I
I
A
E
RRANGD
Q
D
E
K
D
L
L
A
R
M
LNVEDPETGEKLDDEN
I
R
F
Q
I
I
T
F
L
IAGHETT
S
G
L
L
S
F
A
T
Y
F
L
LKH
P
D
K
L
K
K
A
Y
E
E
V
D
R
V
L
TDA
A
P
T
Y
K
Q
V
L
E
L
T
Y
I
R
M
I
L
NESLRLWPTAP-AFSLYPKEDTVIGGKFPITTN
D
R
I
S
V
L
I
P
Q
LHRDRDAWGK
D
A
E
EF
R
P
E
RFEHQDQVPHHAYKPFGNGQ
R
A
C
I
G
M
Q
F
A
L
H
E
A
T
L
V
L
G
M
I
L
K
Y
F
T
L
ID---HEN
Y
E
L
D
I
K
Q
T
L
T
LKPG
D
F
H
I
S
V
Q
SR
H
Q
E
A
I
H
A
D
V
Q
A
A
EKAAP
D
E
Q
K
E
K
T
EAKG
A
S
V
I
GLNNR
P
L
L
V
L
YGSDTG
T
A
E
G
V
A
R
E
L
A
D
T
A
SLHGVRTKTAPL
N
D
R
I
GKLPKE
G
A
V
V
I
V
TSSYNGKPPS
N
A
G
Q
F
V
Q
W
L
Q
EIKPGELE
G
V
H
Y
A
V
F
GCGDH
N
W
A
S
T
Y
Q
Y
V
P
R
F
I
D
E
Q
L
A
E
KGATRFSARGEGDVSGDFEG
Q
L
D
E
W
K
K
S
M
W
A
D
A
I
K
A
FGLELNENADKERS
T
L
S
L
Q
F
V
R
GLGES
P
L
A
R
SYEASHA
S
I
AENRELQSADSDRS
T
R
H
I
E
I
ALPPDVEYQEGDHLGVLPKNSQT
N
V
S
R
I
L
H
R
FGLKGT
D
Q
V
T
L
SASGRSAGHLPLGRP
V
S
L
H
D
L
L
S
Y
S
V
E
V
Q
E
A
A
T
R
A
Q
I
R
E
L
A
SFTVCP
P
H
R
R
E
L
E
E
L
S
AEG
V
Y
Q
E
Q
I
L
K
K
R
I
S
M
L
D
L
L
E
K
Y
E
ACD
M
P
F
E
R
F
L
E
L
L
RPLK
P
R
Y
Y
SISSSPRVNPR
Q
A
S
I
T
V
G
V
VRGPAWSGRGEYRGVASN
D
L
A
ERQAGD
D
V
V
M
F
I
RT
P
E
S
RFQLPKDPET
P
I
I
M
VGPGTG
V
A
P
F
R
G
F
L
Q
A
R
D
V
L
K
REGKTLGE
A
H
L
Y
F
G
CRNDRDF
I
Y
R
D
E
L
E
R
FEKD
G
I
V
T
V
H
TAFSRKEGM
P
K
T
Y
V
Q
H
L
M
AD
Q
A
D
T
L
I
S
I
L
DRG
G
R
L
Y
V
CGDGSKMA
P
D
V
E
A
A
L
Q
K
A
Y
Q
A
VHGT
G
E
Q
E
A
Q
N
W
L
R
H
L
Q
DTGM
Y
A
K
D
V
WAGI
46
PsiBlast_CBE
88.24
66%
-107
- C3 -
1P0X
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
-----
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
Y
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
87.36
66%
-106
- C3 -
2HPD
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
87.26
65%
-106
- C3 -
4DUC
1
CPXB_BACME
A:
[6-452]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
C
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
L
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
S
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
L
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
87.04
66%
-105
- C3 -
4KF2
2
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
F
G
D
G
L
V
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
--
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
87.04
66%
-102
- C3 -
4HGI
6
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
86.85
66%
-104
- C3 -
1ZO4
11
CPXB_BACME
B:
[8-454]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
S
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
86.79
66%
-104
- C3 -
4HGI
7
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
86.78
66%
-107
- C3 -
4HGJ
6
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
-----
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
86.77
66%
-101
- C3 -
4HGH
3
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
86.76
65%
-105
- C3 -
4DUC
1
CPXB_BACME
B:
[6-452]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
C
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
L
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
S
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
L
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
86.55
66%
-103
- C3 -
1P0W
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
-----
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
W
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.50
66%
-101
- C3 -
1ZO4
14
CPXB_BACME
A:
[8-454]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
S
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.44
66%
-105
- C3 -
3WSP
3
CPXB_BACME
A:
[6-452]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.32
66%
-103
- C3 -
2J1M
8
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
86.20
66%
-103
- C3 -
4HGH
6
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
86.07
66%
-106
- C3 -
2J4S
5
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
-----
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.97
66%
-104
- C3 -
3BEN
2
CPXB_BACME
A:
[6-452]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
85.93
66%
-100
- C3 -
4HGJ
3
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
85.88
66%
-106
- C3 -
4KF2
2
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
F
G
D
G
L
V
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
----
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
85.81
66%
-106
- C3 -
4KF0
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
F
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
--
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
85.66
66%
-102
- C3 -
3WSP
3
CPXB_BACME
B:
[6-452]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
85.63
66%
-102
- C3 -
1P0V
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
---------
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
A
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
85.62
66%
-102
- C3 -
3KX5
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
E
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
85.58
66%
-104
- C3 -
2X80
3
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.55
66%
-109
- C3 -
1BVY
3
CPXB_BACME
A:
[20-451]
---------------------------
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.47
66%
-100
- C3 -
1JPZ
2
CPXB_BACME
A:
[8-454]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
85.40
66%
-101
- C3 -
2X80
5
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.38
66%
-104
- C3 -
2HPD
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
85.32
66%
-108
- C3 -
3DGI
2
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
------------------------
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
----
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
A
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
85.26
66%
-107
- C3 -
4KF0
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
F
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
-----------
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
-
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.23
66%
-105
- C3 -
4KPB
1
?
B:
[29-475]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
E
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
---------
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
85.22
66%
-102
- C3 -
4HGG
5
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
R
M
N
K
------------
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
85.15
66%
-103
- C3 -
4KEY
2
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
F
G
D
G
L
V
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
---
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
85.11
66%
-101
- C3 -
1ZOA
6
CPXB_BACME
B:
[8-454]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
V
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
85.02
66%
-101
- C3 -
1BU7
9
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
84.98
66%
-104
- C3 -
3BEN
4
CPXB_BACME
B:
[6-452]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
84.97
66%
-103
- C3 -
2IJ3
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
H
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
84.95
66%
-104
- C3 -
4HGF
2
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
K
M
-------------
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.84
66%
-100
- C3 -
1BU7
7
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
84.78
66%
-101
- C3 -
2J1M
6
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
84.70
66%
-105
- C3 -
4HGG
7
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
R
M
------------------
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.64
66%
-100
- C3 -
2BMH
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
84.53
66%
-104
- C3 -
3EKD
2
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
---
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
M
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
84.51
66%
-105
- C3 -
2IJ2
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
-
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
-------
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
-
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
84.45
66%
-99
- C3 -
1ZOA
3
CPXB_BACME
A:
[8-454]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
V
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
84.40
66%
-100
- C3 -
2IJ3
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
H
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.24
66%
-101
- C3 -
4KPA
2
CPXB_BACME
A:
[29-475]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
---
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
84.23
66%
-106
- C3 -
3EKB
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
C
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
84.16
66%
-102
- C3 -
3DGI
2
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
----
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
A
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
84.16
66%
-100
- C3 -
4KEW
2
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
F
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
---
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
84.08
66%
-99
- C3 -
5DYZ
2
?
C:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
-
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
G
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
H
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
84.03
66%
-98
- C3 -
1JPZ
2
CPXB_BACME
B:
[8-454]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
84.02
66%
-100
- C3 -
3KX4
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
E
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
83.99
66%
-100
- C3 -
5DYZ
1
?
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
---------
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
-
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
G
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
H
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
83.89
66%
-103
- C3 -
3EKF
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
---
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
Q
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
83.88
66%
-102
- C3 -
3EKD
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
M
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.88
66%
-99
- C3 -
1ZO9
12
CPXB_BACME
A:
[8-454]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.85
66%
-99
- C3 -
1ZO9
9
CPXB_BACME
B:
[8-454]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
83.83
66%
-99
- C3 -
3M4V
1
CPXB_BACME
A:
[6-452]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
P
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.69
66%
-101
- C3 -
1FAH
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
A
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
83.59
66%
-103
- C3 -
2BMH
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.54
66%
-101
- C3 -
2J4S
3
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
---
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
83.53
66%
-105
- C3 -
1BVY
4
CPXB_BACME
B:
[21-451]
----------------------------
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
83.45
66%
-102
- C3 -
1SMI
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
-
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
-----------
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
-----
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
E
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
83.44
66%
-100
- C3 -
1SMI
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
E
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
83.43
66%
-100
- C3 -
3KX4
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
E
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
83.41
66%
-103
- C3 -
4HGF
3
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
K
M
-------------
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
83.40
66%
-101
- C3 -
4O4P
2
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
F
G
D
G
L
V
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
---
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
83.33
66%
-102
- C3 -
5DYP
1
?
C:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
----
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
G
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
H
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
83.13
66%
-100
- C3 -
4O4P
2
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
---
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
F
G
D
G
L
V
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
---
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
83.08
66%
-98
- C3 -
3KX3
2
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
E
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
82.90
66%
-98
- C3 -
3KX3
2
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
E
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
82.87
66%
-103
- C3 -
1FAH
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
A
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
82.51
66%
-99
- C3 -
3KX5
2
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
E
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
81.65
66%
-102
- C3 -
3EKF
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
-----------
Q
F
Q
E
--
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
Q
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
81.18
66%
-97
- C3 -
2IJ4
1
CPXB_BACME
B:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
K
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
81.10
66%
-99
- C3 -
3HF2
1
CPXB_BACME
A:
[6-452]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
----
S
M
V
R
A
L
D
E
A
M
--------------
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
-----
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
P
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
80.77
66%
-102
- C3 -
3HF2
1
CPXB_BACME
B:
[6-452]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
------
S
M
V
R
A
L
D
E
------------------
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
----
E
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
P
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.42
66%
-98
- C3 -
3EKB
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
-----------
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
---
Q
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
C
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
80.33
66%
-96
- C3 -
2IJ4
1
CPXB_BACME
A:
[5-451]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
--
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
---
S
D
-
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
K
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
79.85
66%
-104
- C3 -
3PSX
1
CPXB_BACME
A:
[11-457]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
--------------------------------------
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
H
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
V
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
T
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
I
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
79.82
66%
-104
- C3 -
3PSX
1
CPXB_BACME
B:
[11-457]
------
M
P
Q
P
K
T
F
G
E
L
K
N
L
------
P
L
L
N
T
D
K
P
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
--
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
E
S
R
F
D
------
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
H
I
E
--
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
------------------------------------
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
--
Q
S
D
-
D
L
L
T
H
M
L
H
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
V
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
T
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
I
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
---
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
P
E
G
F
V
V
K
A
K
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Fugue
75.81
61%
-98
- C3 -
1JPZ
2
CPXB_BACME
A:
[4-461]
--
T
I
K
E
M
P
Q
P
K
T
F
G
E
L
K
N
-LPLLNT
D
---
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
--G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
D
--
E
S
R
FDKNLS--
Q
A
L
K
F
V
R
D
F
A
--
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
-
A
D
E
H
I
E
V
P
E
-
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
---
S
Q
S
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
A
-
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
-
D
F
E
DHT--
N
Y
E
L
D
I
K
E
T
-
L
T
L
K
P
E
G
-
F
V
V
K
A
K
S
K
K
I
P
L
G
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------