@TOME V2.3
(Nov 2016)

Ref. - - Doc.
Global output mode :
Sort entries by :
Sequence Color type :

Show alignment :
Column output:
Score:

Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : bsu07420: (2016-06-11 )
MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKSTFMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMNEIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDVTDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHDIPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFVARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIGYDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYFEQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVRLCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETWNCESWTTKVL

Atome Classification :

(20 SA) .........10...-.-------....20...-..-...30........40........50.......--.60...--------------...--..70.....-...80....--....90........100.......110..-.....120.......130.......140.......150.......160.......170.......180.......190.......200.....----.----.210-.......220.......230--.......240.......250.....---..260.......270......-.280-.......290........300.......310....--...320.......330...-.----...340----.......350.......360.......370.......380...-----------....390......-.---400..---..------------------------------------------------------------------...410---..-------------------------------------.-.....420.......430---------..-......440.......450.......460.......470....----...480....----...490.......500.......510......
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MSILSVKDLSHGFG-D-------RAIFNNVSF-RL-LKGEHVGLIGANGEGKSTFMNIITGKLEPDEG--KVEWSK--------------NVR--VGYLDQHTV-LEKGKSIRD--VLKDAFHYLFAMEEEMNEIYNKMGEADPD-ELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDVTDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQE----Y----ENAF-ILISHDIPFLNSVINLIYHV--ENQELTRYVGDYHQFMEVYEVKKQQ---LEAAYKKQQQEVAELKDFVAR-NKAR-VSTRNMAM-SRQKKLDKMDMIELAAEKPKPEFHFK--PARTSGKLIFETKDLVIGY-D----SPLSRP----LNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGE-----------HIYTGYFEQEVKE-T---NNNTC---IE------------------------------------------------------------------EVWSE----FP-------------------------------------S-YTQYEIRAALAKCGLTT----------KH-IESRVSVLSGGEKAKVRLCKLINSETNLLVLDEPTNHLDADAK----EELKRALKEY----KGSILLISHEPDFYMDIATETWNCESWTTKVL
21 HHSearch 78.2529% -84 - C1 -4FIN ETTA_ECOLI A:[4-517] -FVYTMHRVGKVVPPK-------RHILKNISL-SF-FPGAKIGVLGLNGAGKSTLLRIMAGIDKDIEG--EARPQP--------------DIK--IGYLPQEPQ-LNPEHTVRE--SIEEAVSEVVNALKRLDEVYALYADPD-A-DFDKLAAEQGRLEEIIQ------LNVQLERAADALRLP--DWDAKIANLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHD----F----EGTV-VAITHDRYFLDNVAGWILEL--DRGEGIPWEGNYSSWLEQKDQRLAQ---EASQEAARRKSIEKELEWVRQGTK-----K---GK-ARLARFEELNSTEYQKRNETNELFIP--PGPRLGDKVLEVSNLRKSY-GD---RLLIDD----LSFSIPKGAIVGIIGPNGAGKSTLFRMISGQEQPDSGTITLGE-----------TVKLASVDQFRDSMD---NSKTV---WE------------------------------------------------------------------EVSGG----LDIMKI---------------------------------G-NTEMPSRAYVGRFNFKG----------VD-QGKRVGELSGGERGRLHLAKLLQVGGNMLLLDEPTNDLDIETL----RALENALLEF----PGCAMVISHDRWFLDRIATHILDYQDE-----
2 PsiBlast_PDB 74.2830% -76 - C1 -4FIN ETTA_ECOLI A:[19-509] -----------------------RHILKNISL-SF-FPGAKIGVLGLNGAGKSTLLRIMAGIDKDIEG--EARPQP--------------DIK--IGYLPQEPQ-LNPEHTVRE--SIEEAVSEVVNALKRLDEVYALY--ADPDADFDKLAAEQGRLEEIIQ------LNVQLERAADALRLPD--WDAKIANLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHD----F----EGTV-VAITHDRYFLDNVAGWILEL--DRGEGIPWEGNYSSWLEQKDQRLAQEASQEAARRKSIEK--ELEWVRQG-TK-----K---GK-ARLARFEELNSTEYQKRNETNELFIP--PGPRLGDKVLEVSNLRKSYGD----RLLIDD----LSFSIPKGAIVGIIGPNGAGKSTLFRMISGQEQPDSGTITLGE-----------TVKLASVDQ-FRD-S---MDNS-----K------------------------------------------------------------------TVWEE----VSGGLDIMKI-----------------------------G-NTEMPSRAYVGRFNFKG----------VD-QGKRVGELSGGERGRLHLAKLLQVGGNMLLLDEPTNDLDIETL----RALENALLEF----PGCAMVISHDRWFLDRIAT-------------
22 HHSearch 72.9330%-101 - C1 -2IW3 EF3A_YEAST A:[439-977] ------CEFSLAYG-A-------KILLNKTQL-RL-KRARRYGICGPNGCGKSTLMRAIANGQV--DG--FP-TQE--------------ECR--TVYVEHDIDGTHSDTSVLD--FVFESGV---------------------------------------------GTKEAIKDKLIEFGFTDEMIAMPISALSGGWKMKLALARAVLRNADILLLDEPTNHLDTVNVAWLVNYLNT----C----GITS-ITISHDSVFLDNVCEYIINY--EGLKLRKYKGNFTEFVKKCPAA---------------KAYEELSN---T----D-------L---E-FKF--------PE----P-GYLE--GVKTKQKAIVKVTNMEFQY-PGTS-KPQITD----INFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHE-----------NCRIAYIKQHAFAHIESHLDKTP---SEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRIAGIHSRRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWIPRGELVESHSKMVAEVDMKEALASGQFRP-LTRKEIEEHCSMLGLDP----------EIVSHSRIRGLSGGQKVKLVLAAGTWQRPHLIVLDEPTNYLDRDSL----GALSKALKEF----EGGVIIITHSAEFTKNLTEEVWAVKDGRMT--
1 PsiBlast_PDB 67.8930% -56 - C1 -3J5S - ETTA_ECOLI D:[19-509] -----------------------RHILKNISL-SF-FPGAKIGVLGLNGAGKSTLLRIMAGIDKDIEG--EARPQP--------------DIK--IGYLPQEPQ-LNPEHTVRE--SIEEAVSEVVNALKRLDEVYALY--ADPDADFDKLAAEQGRLEEIIQAHDGHNLNVQLERAADALRLPD--WDAKIANLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHD----F----EGTV-VAITHDRYFLDNVAGWILEL--DRGEGIPWEGNYSSWLEQKDQRLAQEASQEAARRKSIEK--ELEWVRQG-TKGR-QSK---GK-ARLARFEELNSTEYQKRNETNELFIP--PGPRLGDKVLEVSNLRKSYGD----RLLIDD----LSFSIPKGAIVGIIGPNGAGKSTLFRMISGQEQPDSGTITLGE-----------TVKLASVDQFRDS-M---DNSKT------------------------------------------------------------------------VWEE----VSGGLDIMKI-----------------------------G-NTEMPSRAYVGRFNFKG----------VD-QGKRVGELSGGERGRLHLAKLLQVGGNMLLLDEPTNDLDIETL----RALENALLEF----PGCAMVISHDRWFLDRIAT-------------
40 HHSearch 57.6427%-130 - C1 -2YYZ ? A:[2-222] -PSIRVVNLKKYFG-K-------VKAVDGVSF-EV-KDGEFVALLGPSGCGKTTTLLMLAGIYKPTSG--EIYFDDVLVNDIPPK-----YRE--VGMVFQNYA-LYPHMTVFE--NIAFPLRARR--------------------------------------ISKDEVEKRVVEIARKLLIDN-LLDRKPTQLSGGQQQRVALARALVKQPKVLLFDEPLSNLDANLRMIMRAEIKH----LQQELGITS-VYVTHDQAEAMTMASRIAVF--NQGKLVQY-GTPDEVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41 HHSearch 55.2726%-136 - C1 -1OXX ? K:[1-230] MVRIIVKNVSKVFK-KGK-----VVALDNVNI-NI-ENGERFGILGPSGAGKTTFMRIIAGLDVPSTG--ELYFDDRLVASNGKLIVPPEDRK--IGMVFQTWA-LYPNLTAFE--NIAFPLTNMK--------------------------------------MSKEEIRKRVEEVAKILDIHH-VLNHFPRELSGAQQQRVALARALVKDPSLLLLDEPFSNLDARMRDSARALVKE----VQSRLGVTL-LVVSHDPADIFAIADRVGVL--VKGKLVQV-GKPEDLYD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37 HHSearch 53.6327%-126 - C1 -3FVQ FBPC_NEIG1 A:[2-233] TAALHIGHLSKSFQ-N-------TPVLNDISL-SL-DPGEILFIIGASGCGKTTLLRCLAGFEQPDSG--EISLSGKTIFSKNTNLPVR-ERR--LGYLVQEGV-LFPHLTVYR--NIAYGLGNGKG--------------------------------------RTAQERQRIEAMLELTGISE-LAGRYPHELSGGQQQRAALARALAPDPELILLDEPFSALDEQLRRQIREDMIAALRAN----GKSA-VFVSHDREEALQYADRIAVM--KQGRILQT-ASPHELYR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42 HHSearch 52.1623%-132 - C1 -1V43 - ? A:[10-237] MVEVKLENLTKRFG-N-------FTAVNKLNL-TI-KDGEFLVLLGPSGCGKTTTLRMIAGLEEPTEG--RIYFGDRDVTYLPPK-----DRN--ISMVFQ-------HMTVYE--NIAFPL--KK--------------------------------------FPKDEIDKRVRWAAELLQIEE-LLNRYPAQLSGGQRQRVAVARAIVVEPDVLLMDEPLSNLDAKLRVAMRAEIKK----LQQKLKVTT-IYVTHDQVEAMTMGDRIAVM--NRGQLLQI-GSPTEVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34 HHSearch 51.1324%-139 - C1 -4TQU - ? S:[2-223] VASVSIQNVVKRYD-K-------TTVVHGVSL-DI-EPGEFVVLVGPSGCGKSTTLRMVAGLEEISGG--TIRIDGRVINDLAPK-----DRD--VAMVFQNYA-LYPHLNVRD--NISFGLRLKR-T-------------------------------------KKSVIDAAVKTAADILGLQP-LLERKPSDLSGGQRQRVAMGRAIVRDPKVFLFDQPLSNLDAKLRTQMRAEIKR----LHQRLGTTV-IYVTHDQVEAMTLADRIVVM--RDGLIEQI-GKPMDLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39 HHSearch 51.1023%-130 - C1 -4YER ? A:[3-253] EDIIVVENLVKKFG-D-------FEAVKGVSF-SV-KKGEIFAFLGPNGAGKTTTIHMLTTLLKPTSG--KAWVAGHDVLKEPREV----RRK--IGIVFQDQS-LDRELTAYE--NMYIHGKIYG-Y-------------------------------------GGEKLKKRILELLEFVELLE-FKDKPVKTFSGGMARRLEIARSLIHEPEVLFLDEPTIGLDPHTRAHMWEYISK----MKKEHNMTI-FLTTHYMDEAEQLADRVAII--DHGKIIAL-GTPTELK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38 HHSearch 51.0227%-133 * C1 *2IT1 - ? A:[1-222] MVEIKLENIVKKFG-N-------FTALNNINL-KI-KDGEFMALLGPSGSGKSTLLYTIAGIYKPTSG--KIYFDEKDVTELPPK-----DRN--VGLVFQNWA-LYPHMTVYK--NIAFPLELRKA--------------------------------------PREEIDKKVREVAKMLHIDK-LLNRYPWQLSGGQQQRVAIARALVKEPEVLLLDEPLSNLDALLRLEVRAELKR----LQKELGITT-VYVTHDQAEALAMADRIAVI--REGEILQV-GTPDEVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36 HHSearch 50.6325%-133 - C1 -1Z47 ? A:[13-235] -MTIEFVGVEKIYPGG-------ARSVRGVSF-QI-REGEMVGLLGPSGSGKTTILRLIAGLERPTKG--DVWIGGKRVTDLPPQ-----KRN--VGLVFQNYA-LFQHMTVYD--NVSFGLREKR-V-------------------------------------PKDEMDARVRELLRFMRLES-YANRFPHELSGGQQQRVALARALAPRPQVLLFDEPFAAIDTQIRRELRTFVRQ----VHDEMGVTS-VFVTHDQEEALEVADRVLVL--HEGNVEQF-GTPEEVYE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23 HHSearch 49.9023% -85 - C1 -3BK7 ? A:[83-547] --AISIVNLPEQLD-EDCVHRYGVNAFVLYRL-PIVKDGMVVGIVGPNGTGKTTAVKILAGQLIPNLC--EDNDS---------------WDN--VIRAFRGNE-LQNYFERLKNGEIRPVVKP-----QYVDLLP--------K-AV----K--GKVRELL---KKVDEVGKFEEVVKELELEN-VLDRELHQLSGGELQRVAIAAALLRKAHFYFFDEPSSYLDIRQRLKVARVIRR----LANE-GKAV-LVVEHDLAVLDYLSDVIHVV--YGEPG-VY-GIFSKPKGTRN---------------------GINEFLQG-YLKD-EN----VR-FRPY---------------EIRFTKLSERVDVERETLVEYPRLVKDY-G----SFKLEV----EPGEIRKGEVIGIVGPNGIGKTTFVKMLAGVEEPTEGKVEWD-------------LTVAYKPQYIKA-E---YEGTV---YE------------------------------------------------------------------LLSKI----DSSK-----------------------------------L-NSNFYKTELLKPLGII-----------DL-YDRNVEDLSGGELQRVAIAATLLRDADIYLLDEPSAYLDVEQR----LAVSRAIRHLMEKNEKTALVVEHDVLMIDYVSDRLIVFEG------
26 HHSearch 49.4421% -88 - C1 -3OZX ? A:[4-463] -------EVIHRYK---------VNGFKLFGLPTP-KNNTILGVLGKNGVGKTTVLKILAGEIIPNFG--DPNSKVGKDEVLKRFR----GKE--IYNYFKELY--SNELKIVH--KIQYVEYA-SKFL-------------------K------GTVNEIL---TKIDERGKKDEVKELLNMTN-LWNKDANILSGGGLQRLLVAASLLREADVYIFDQPSSYLDVRERMNMAKAIRE----LLK--NKYV-IVVDHDLIVLDYLTDLIHII--YGE-SSVY-GRVSKSYAARVG------------------I---NNFLKG-YLPA--ENMKIRPDEIKFMLK--------------------------LKTKMKWTKIIKKL-G----DFQLVV----DNGEAKEGEIIGILGPNGIGKTTFARILVGEITADEGSVTPE------------KQILSYKPQRIFP-N---YDGTV---QQ------------------------------------------------------------------YLENA----SKDAL----------------------------------S-TSSWFFEEVTKRLNLH-----------RL-LESNVNDLSGGELQKLYIAATLAKEADLYVLDQPSSYLDVEER----YIVAKAIKRVTRERKAVTFIIDHDLSIHDYIADRIIVFKGEP----
27 HHSearch 49.2125% -81 - C1 -1YQT ? A:[25-478] ------EDCVHRYG-VN------AFVLYRLP--VV-KEGMVVGIVGPNGTGKSTAVKILAGQLIPNLCGDNDSWDG--------------VIRAFRGNELQNYFEKLKNGEIRP--VVKPQYVDL------IPKAV------------------KGKVIEL---LKKADETGKLEEVVKALELEN-VLEREIQHLSGGELQRVAIAAALLRNATFYFFDEPSSYLDIRQRLNAARAIRR----LSEE-GKSV-LVVEHDLAVLDYLSDIIHVV--YGEPG-VY-GIFSQPKGTRN------------------GI---NEFLRG-YLKDENVRFRPYE----IKFTK--------------T-GE--RVEIERETLVTYPRLVKDY-G----SFRLEV----EPGEIKKGEVIGIVGPNGIGKTTFVKMLAGVEEPTEGKIEWDL-------------TVAYKPQYIKA-D---YEGTV---YE------------------------------------------------------------------LLSKI----DAS------------------------------------KLNSNFYKTELLKPLGII-----------DL-YDREVNELSGGELQRVAIAATLLRDADIYLLDEPSAYLDVEQR----LAVSRAIRHLMEKNEKTALVVEHDVLMIDYVSDRLMVFEGE-----
7 PsiBlast_PDB 48.4424% -81 - C1 -3OZX ? A:[28-453] -----------------------------------------LGVLGKNGVGKTTVLKILAGEIIPNFG------DP--------------NSK--VGK-DEVLK-RFRGKEIYN--YFKELYSNELKIVHKIQYV---------E-YASKFLK--GTVNEILTKIDE---RGKKDEVKELLNMTNL-WNKDANILSGGGLQRLLVAASLLREADVYIFDQPSSYLDVRERMNMAKAIRE----LL---KNKYVIVVDHDLIVLDYLTDLIHIIYGESSVYGRVSKSYAARVGINNFLKGY---LPAENMKIRPD--EIKFML--------------------K--------------------LK--TKMKWTKIIKKLGDFQLVV-D---------------NGEAKEGEIIGILGPNGIGKTTFARILVGEITADEGSVTPEK-----------QILS-YKPQRIFP-N---YDGTVQQYLE------------------------------------------------------------------NASKD----AL-------------------------------------S-TSSWFFEEVTKRLNLH-----------RL-LESNVNDLSGGELQKLYIAATLAKEADLYVLDQPSSYLDVEERYIVAKAIKRVTRER----KAVTFIIDHDLSIHDYIA--------------
4 PsiBlast_PDB 46.0625%-114 - C1 -2IX3 EF3A_YEAST A:[440-743] -------EFSLAYG-A-------KILLNKTQL-RL-KRARRYGICGPNGCGKSTLMRAIAN-----------------------------------GQVDG------------------------FPTQEECRTVYV---EHDID-GTHSDTSVLDFVFESGVGTKEAIKDKLIE-----FGFTDEMIAMPISALSGGWKMKLALARAVLRNADILLLDEPTNHLDTVNVAWLVNYLNT----C----GITS-ITISHDSVFLDNVCEYIINY--EGLKLRKYKGNFTEF-----VKKCP---AAKAY-------------------------------------EELSNTDLEFKFPEPGY-LE--GVKTKQKAIVKVTNMEFQY-P----G-TSKPQITDINFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHE-----------NCRIAYIKQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28 HHSearch 46.0222%-118 - C1 -4F4C - PGP1_CAEEL A:[1075-1294] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKVIFKNVRFAY-PERPEIEILKG----LSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTL-F----DCSI---AE------------------------------------------------------------------NIIYG----LDPS-----------------------------------S-VTMAQVEEAARLANIHNFIAELPEGFETR-VGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE----KVVQEALDRARE--GRTCIVIAHRLNTVMN-ADCIAVVSNGTII--
3 PsiBlast_PDB 45.9525%-114 - C1 -2IWH EF3A_YEAST A:[440-743] -------EFSLAYG-A-------KILLNKTQL-RL-KRARRYGICGPNGCGKSTLMRAIAN-----------------------------------GQVDG------------------------FPTQEECRTVYV---EHDID-GTHSDTSVLDFVFESGVGTKEAIKDKLIE-----FGFTDEMIAMPISALSGGWKMKLALARAVLRNADILLLDEPTNHLDTVNVAWLVNYLNT----C----GITS-ITISHDSVFLDNVCEYIINY--EGLKLRKYKGNFTEF-----VKKCP---AAKAY-------------------------------------EELSNTDLEFKFPEPGY-LE--GVKTKQKAIVKVTNMEFQY-P----G-TSKPQITDINFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHE-----------NCRIAYIKQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 43.6424%-113 - C1 -2IW3 EF3A_YEAST A:[440-743] -------EFSLAYG-A-------KILLNKTQL-RL-KRARRYGICGPNGCGKSTLMRAIAN-----------------------------------GQVDG------------------------FPTQEECRTVYV---EHDID-GTHSDTSVLDFVFESGVGTKEAIKDKLIE-----FGFTDEMIAMPISALSGGWKMKLALARAVLRNADILLLDEPTNHLDTVNVAWLVNYLNT----C----GITS-ITISHDSVFLDNVCEYIINY--EGLKLRKYKGNFTEF-----VKKCP---AAKAY-------------------------------------EELSNTDLEFKFPEPGY-LE--GVKTKQKAIVKVTNMEFQY-P----G-TSKPQITDINFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHE-----------NCRIAYIKQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------