@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu07430: (2016-06-11 )
MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDVIAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELRAASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVLPEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVKHQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAKKMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRAGKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK
Atome Classification :
(51 SA)
.........10.........20........30........--40--........50........60..-----....-..------------------70--------.---------.-..----.....80........90-.-...-....-100........110--.......-120.-.......130...-..-..140-........150.......----160.-.......170.----.----.---....180---------.......190.......200.......210........220..-.....-230---...-.-.-.--..240---.-.......250.......260.......----270.......280.......290.......300.......310.......-------320-..------......330.......340.......-350.......360.......370....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTQT
W
P
F
L
H
N
-
A
Q
S
F
I
Q
ENWNASGFQKPT
P
V
Q
E
Q
A
A
Q
L
I
M--D
G
--
K
D
VIAESPTGTG
K
T
L
A
Y
A
L
P
V
L
-----
E
RIK-PE------------------Q---------K---------H-P
Q
----
A
V
I
LAP
S
R
E
L
V
M
Q
I
F
Q
V
-
I
-
Q
D
W-KAGS-E-L
R
A
A
S
LIGG
A
N
V
--
K
K
Q
V
E
K
L
-
K
K-H-P
H
I
I
VGT
P
G
R
V
F
E
-
L
I
-
K
A
KK--
L
K
M
H
E
V
K
T
I
V
LDETDQLV----L
P
-
E
-
H
R
E
T
M
K
Q
I
I
K
T
----
T
----L---RDR
Q
L
L
C
---------
F
S
A
TLK
K
E
T
E
D
V
L
R
E
L
AQEP
E
V
L
K
V
Q
RS-KAEAGK
V
K
H
Q
Y
L
I
C-DQ
R
D
K
-
V
-
K
---
L
L
Q
-
K
-
L
-
S
--
R
LE
G
----
M
-
Q
A
L
V
F
V
RDIG
N
L
S
V
Y
A
E
K
L
A
Y
H
H
V
E
L
G
----
V
L
H
S
E
A
K
K
M
E
R
A
K
I
I
A
T
FEDG
E
F
P
L
L
L
A
T
D
I
A
ARGLDIENL
P
Y
V
I
HADIP-------D-E-DG------
Y
V
HRSGRTGRAGKEG
N
V
L
S
L
V
T
K
L
E
E
-
S
K
L
K
K
M
A
K
K
LG
V
E
L
S
E
A
VYAGGKLKTK
22
PsiBlast_CBE
82.08
31%
-126
- C4 -
4CT4
2
DDX6_HUMAN
D:
[24-366]
-----------------------
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
-----
E
R
L
D
-
L
K
------------------
K
---------
D
---------
N
-
I
Q
----
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
-
Q
V
S
-
K
H
M
G
-
G
-
A
K
V
M
A
T
T
G
G
T
N
L
--
R
D
D
I
M
R
L
-
D
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
-
K
K
G
V
--
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
----
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
---
K
N
R
Q
I
L
L
---------
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
-
L
T
L
K
G
-
V
T
Q
Y
Y
A
Y
V
-
T
E
R
Q
K
-
V
-
H
---
C
L
N
-
T
-
L
F
S
--
R
L
Q
I
----
N
-
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
----
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
----
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
-------
K
L
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
-------------
1
PsiBlast_PDB
82.04
31%
-132
- C4 -
4CT4
3
DDX6_HUMAN
B:
[24-366]
-----------------------
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
-----
E
R
L
D
-
L
K
------------------
K
---------
D
---------
N
-
I
Q
----
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
-
Q
V
S
-
K
H
M
G
-
G
-
A
K
V
M
A
T
T
G
G
T
N
L
--
R
D
D
I
M
R
L
-
D
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
-
K
K
G
V
--
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
----
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
---
K
N
R
Q
I
L
L
---------
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
-
L
T
L
K
G
-
V
T
Q
Y
Y
A
Y
V
-
T
E
R
Q
K
-
V
-
H
---
C
L
N
-
T
-
L
F
S
--
R
L
Q
I
----
N
-
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
----
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
-------
K
L
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
-------------
9
PsiBlast_PDB
80.22
30%
-113
- C4 -
2HYI
3
IF4A3_HUMAN
C:
[55-402]
---------------------
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
-----
Q
C
L
D
-
I
Q
------------------
V
---------
R
---------
E
-
T
Q
----
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
-
L
-
L
A
L
-
G
D
Y
M
-
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
L
-
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
-
R
R
R
S
--
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
----
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
---
P
A
T
Q
V
V
L
---------
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
G
I
K
-
Q
F
F
V
A
-
V
E
R
E
E
-
W
-
K
F
D
T
L
C
D
-
L
-
Y
-
D
--
T
L
T
I
----
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
-------
N
-
N
R
E
L
------
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
-----------
12
PsiBlast_PDB
80.01
30%
-111
- C4 -
2J0S
3
IF4A3_HUMAN
A:
[54-401]
---------------------
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
-----
Q
C
L
D
-
I
Q
------------------
V
---------
R
---------
E
-
T
Q
----
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
-
L
-
L
A
L
-
G
D
Y
M
-
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
L
-
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
-
R
R
R
S
--
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
----
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
---
P
A
T
Q
V
V
L
---------
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
G
I
K
-
Q
F
F
V
A
-
V
E
R
E
E
-
W
-
K
F
D
T
L
C
D
-
L
-
Y
-
D
--
T
L
T
I
----
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
-------
N
-
N
R
E
L
------
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
-----------
10
PsiBlast_PDB
79.85
30%
-111
- C4 -
3EX7
4
IF4A3_HUMAN
C:
[55-402]
---------------------
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
-----
Q
C
L
D
-
I
Q
------------------
V
---------
R
---------
E
-
T
Q
----
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
-
L
-
L
A
L
-
G
D
Y
M
-
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
L
-
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
-
R
R
R
S
--
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
----
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
---
P
A
T
Q
V
V
L
---------
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
G
I
K
-
Q
F
F
V
A
-
V
E
R
E
E
-
W
-
K
F
D
T
L
C
D
-
L
-
Y
-
D
--
T
L
T
I
----
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
-------
N
-
N
R
E
L
------
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
-----------
3
PsiBlast_PDB
79.77
31%
-136
- C4 -
5ANR
-
DDX6_HUMAN
B:
[115-457]
-----------------------
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
-----
E
R
L
D
-
L
K
------------------
K
---------
D
---------
N
-
I
Q
----
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
-
Q
V
S
-
K
H
M
G
-
G
-
A
K
V
M
A
T
T
G
G
T
N
L
--
R
D
D
I
M
R
L
-
D
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
-
K
K
G
V
--
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
----
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
---
K
N
R
Q
I
L
L
---------
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
-
L
T
L
K
G
-
V
T
Q
Y
Y
A
Y
V
-
T
E
R
Q
K
-
V
-
H
---
C
L
N
-
T
-
L
F
S
--
R
L
Q
I
----
N
-
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
----
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
----
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
-------
K
L
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
----
L
G
L
A
I
N
L
I
T
Y
D
D
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
-------------
8
PsiBlast_PDB
79.29
30%
-112
- C4 -
2XB2
4
IF4A3_HUMAN
A:
[55-402]
---------------------
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
-----
Q
C
L
D
-
I
Q
------------------
V
---------
R
---------
E
-
T
Q
----
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
-
L
-
L
A
L
-
G
D
Y
M
-
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
L
-
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
-
R
R
R
S
--
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
----
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
---
P
A
T
Q
V
V
L
---------
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
G
I
K
-
Q
F
F
V
A
-
V
E
R
E
E
-
W
-
K
F
D
T
L
C
D
-
L
-
Y
-
D
--
T
L
T
I
----
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
-------
N
-
N
R
E
L
------
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
-----------
105
HHSearch
78.90
29%
-138
- C4 -
5ANR
-
DDX6_HUMAN
B:
[96-462]
----
N
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
-----
E
R
L
D
-
L
K
------------------
K
---------
D
---------
N
-
I
Q
----
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
-
C
-
I
Q
V
-
S
K
H
M
G
G
-
A
K
V
M
A
T
T
G
G
T
N
L
--
R
D
D
I
M
R
L
-
D
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
-
K
K
G
V
--
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
----
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
---
K
N
R
Q
I
L
L
---------
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
--
L
T
L
K
G
V
T
Q
Y
Y
A
Y
V
-
T
E
R
Q
K
-
V
-
H
---
C
L
N
T
L
-
F
-
S
--
R
L
Q
I
----
N
-
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
----
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
----
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K------
L
-
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
----
L
G
L
A
I
N
L
I
T
Y
D
D
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
P
I
P
S
--------
21
PsiBlast_CBE
78.86
31%
-131
- C4 -
4CT5
1
DDX6_HUMAN
B:
[24-366]
-----------------------
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
-----
E
R
L
D
-
L
K
------------------
K
---------
D
---------
N
-
I
Q
----
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
-
Q
V
S
-
K
H
M
G
-
G
-
A
K
V
M
A
T
T
G
G
T
N
L
--
R
D
D
I
M
R
L
-
D
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
-
K
K
G
V
--
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
----
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
---
K
N
R
Q
I
L
L
---------
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
-
L
T
L
K
G
-
V
T
Q
Y
Y
A
Y
V
-
T
E
R
Q
K
-
V
-
H
---
C
L
N
-
T
-
L
F
S
--
R
L
Q
I
----
N
-
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
----
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
-------
K
L
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
-------------
11
PsiBlast_PDB
78.67
30%
-108
- C4 -
2J0Q
3
IF4A3_HUMAN
A:
[54-401]
---------------------
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
-----
Q
C
L
D
-
I
Q
------------------
V
---------
R
---------
E
-
T
Q
----
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
-
L
-
L
A
L
-
G
D
Y
M
-
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
L
-
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
-
R
R
R
S
--
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
----
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
---
P
A
T
Q
V
V
L
---------
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
G
I
K
-
Q
F
F
V
A
-
V
E
R
E
E
-
W
-
K
F
D
T
L
C
D
-
L
-
Y
-
D
--
T
L
T
I
----
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
-------
N
-
N
R
E
L
------
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
-----------
113
HHSearch
78.59
29%
-141
- C4 -
1XTI
4
DX39B_HUMAN
A:
[10-377]
------
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
-----
Q
Q
L
E
-
P
V
------------------
T
---------
G
---------
Q
-
V
S
----
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
-
Y
-
E
R
F
-
S
K
Y
M
P
N
-
V
K
V
A
V
F
F
G
G
L
S
I
--
K
K
D
E
E
V
L
K
K
N
-
C
-
P
H
I
V
V
G
T
P
G
R
I
L
A
-
L
A
-
R
N
K
S
--
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
----
E
Q
L
D
-
M
R
R
D
V
Q
E
I
F
R
M
----
T
----
P
---
H
E
K
Q
V
M
M
---------
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
T
K
L
T
L
H
G
L
Q
Q
Y
Y
V
K
L
-
K
D
N
E
K
N
R
-
K
---
L
F
D
-
L
-
L
-
D
--
V
L
E
F
----
N
-
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
N
F
P
A
I
----
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E------
D
-
S
-
D
T
------
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
S
D
E
N
D
A
K
I
L
N
D
V
Q
D
R
F
E
V
N
I
S
E
L
----------
2
PsiBlast_PDB
78.58
31%
-130
- C4 -
4CT5
1
DDX6_HUMAN
A:
[24-366]
-----------------------
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
--
S
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
-----
E
R
L
D
-
L
K
------------------
K
---------
D
---------
N
-
I
Q
----
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
-
Q
V
S
-
K
H
M
G
-
G
-
A
K
V
M
A
T
T
G
G
T
N
L
--
R
D
D
I
M
R
L
-
D
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
-
K
K
G
V
--
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
----
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
---
K
N
R
Q
I
L
L
---------
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
-
L
T
L
K
G
-
V
T
Q
Y
Y
A
Y
V
-
T
E
R
Q
K
-
V
-
H
---
C
L
N
-
T
-
L
F
S
--
R
L
Q
I
----
N
-
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
----
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
-------
K
L
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
-------------
107
HHSearch
78.10
29%
-126
- C4 -
1S2M
-
DHH1_YEAST
A:
[46-409]
----
N
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
--
T
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
-----
E
K
V
K
-
P
K
------------------
L
---------
N
---------
K
-
I
Q
----
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
-
V
-
R
T
L
-
G
K
H
C
-
G
-
I
S
C
M
V
T
T
G
G
T
N
L
--
R
D
D
I
L
R
L
-
N
E
-
T
-
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
-
S
R
K
V
--
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
----
S
R
-
D
-
F
K
T
I
I
E
Q
I
L
S
F
----
L
----
P
---
P
T
H
Q
S
L
L
---------
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
--
L
T
L
K
G
I
T
Q
Y
Y
A
F
V
-
E
E
R
Q
K
-
L
-
H
---
C
L
N
-
T
L
F
-
S
--
K
L
Q
I
----
N
-
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
----
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K------
T
-
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
-
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
A
I
----------
6
PsiBlast_PDB
77.47
30%
-127
- C4 -
1S2M
-
DHH1_YEAST
A:
[64-407]
----------------------
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
--
T
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
-----
E
K
V
K
-
P
K
------------------
L
---------
N
---------
K
-
I
Q
----
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
-
V
-
R
T
L
-
G
K
H
C
-
G
-
I
S
C
M
V
T
T
G
G
T
N
L
--
R
D
D
I
L
R
L
-
N
E
-
T
-
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
-
S
R
K
V
--
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
----
S
R
-
D
-
F
K
T
I
I
E
Q
I
L
S
F
----
L
----
P
---
P
T
H
Q
S
L
L
---------
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
-
L
T
L
K
G
-
I
T
Q
Y
Y
A
F
V
-
E
E
R
Q
K
-
L
-
H
---
C
L
N
-
T
-
L
F
S
--
K
L
Q
I
----
N
-
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
----
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K------
T
-
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
-
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
------------
121
HHSearch
76.74
31%
-128
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[17-387]
------
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
--
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
-----
S
Q
I
Y
-
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
---------
Q
---------
Y
-
P
I
----
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
-
A
-
R
K
F
-
S
Y
R
S
-
R
-
V
R
P
C
V
V
Y
G
G
A
D
I
--
G
Q
Q
I
R
D
L
-
E
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
-
E
R
G
K
--
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
----
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
----
D
TMPP
K
---
G
V
R
H
T
M
M
---------
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-----
T
S
E
N
I
T
Q
K
V
V
W
V
-
E
E
S
D
K
-
R
-
S
---
F
L
L
-
D
-
L
-
L
N
A
T
G
K
D
----
S
-
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
----
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S------
D
-
I
-
E
E
------
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
I
-
N
I
-------------------------
114
HHSearch
75.75
30%
-104
- C4 -
2DB3
3
VASA1_DROME
A:
[58-408]
------
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
--
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
-----
S
K
L
L
-
E
D
------------------
P
H
E
L
E
L
----
G
---------
R
-
P
Q
----
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
-
A
-
R
K
F
-
A
F
E
S
-
Y
-
L
K
I
G
I
V
Y
G
G
T
S
F
--
R
H
Q
N
E
C
I
-
T
R
-
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
-
F
V
-
D
R
T
F
--
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
----
D
M
-
G
-
F
S
E
D
M
R
R
I
M
T
H
----
V
TM--
R
---
P
E
H
Q
T
L
M
---------
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
-
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
-
N
K
Y
A
K
R
S
-
K
---
L
I
E
-
I
---
L
--
S
E
Q
A
----
D
-
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
----
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S------
K
-
I
-
D
D
------
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
-----------------------------
109
HHSearch
75.65
30%
-106
- C4 -
4D25
4
?
A:
[57-409]
-----------
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
--
S
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
-----
N
M
L
L
-
Q
D
------------------
P
KD
L
I
S
E
NG
C
A
---------
Q
-
P
Q
----
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
-
A
-
R
K
F
-
S
Y
G
S
-
V
-
L
K
V
A
V
A
Y
G
G
T
A
V
--
R
H
Q
G
D
N
I
-
A
R
-
G
-
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
-
E
R
N
R
--
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
----
D
M
-
G
-
F
M
P
S
I
E
K
M
M
L
H
PTMV
E
----
T
---
T
K
R
Q
T
L
M
---------
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
-
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
-
T
K
Y
E
K
-
R
N
S
---
L
K
Q
-
L
-
I
-
E
--
E
N
D
G
----
K
-
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
----
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K------
S
-
I
-
D
E
------
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
-----------------------------
4
PsiBlast_PDB
75.32
30%
-125
- C4 -
4BRU
-
DHH1_YEAST
A:
[64-407]
----------------------
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
--
T
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
-----
E
K
V
K
-
P
K
------------------
L
---------
N
---------
K
-
I
Q
----
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
-
V
-
R
T
L
-
G
K
H
C
-
G
-
I
S
C
M
V
T
T
G
G
T
N
L
--
R
D
D
I
L
R
L
-
N
E
-
T
-
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
-
S
R
K
V
--
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
----
S
R
-
D
-
F
K
T
I
I
E
Q
I
L
S
F
----
L
----
P
---
P
T
H
Q
S
L
L
---------
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
-
L
T
L
K
G
-
I
T
Q
Y
Y
A
F
V
-
E
E
R
Q
K
-
L
-
H
---
C
L
N
-
T
-
L
F
S
--
K
L
Q
I
----
N
-
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
----
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K------
T
-
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
-
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
------------
7
PsiBlast_PDB
75.17
30%
-118
- C4 -
2HXY
-
IF4A3_HUMAN
A:
[55-402]
---------------------
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
--
K
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
-----
Q
C
L
D
-
I
Q
------------------
V
---------
R
---------
E
-
T
Q
----
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
-
L
-
L
A
L
-
G
D
Y
M
-
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
L
-
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
-
R
R
R
S
--
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
----
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
---
P
A
T
Q
V
V
L
---------
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
G
I
K
-
Q
F
F
V
A
-
V
E
R
E
E
-
W
-
K
F
D
T
L
C
D
-
L
-
Y
-
D
--
T
L
T
I
----
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
----
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
-------
N
-
N
R
E
L
------
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
-----------
13
PsiBlast_PDB
74.89
29%
-120
- C4 -
1HV8
5
H669_METJA
A:
[25-355]
-----------------------
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
-
D
E
--
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
-----
E
L
V
N
--
E
------------------
N
---------
N
---------
G
-
I
E
----
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
-
I
-
E
S
L
-
K
G
N
K
-
N
-
L
K
I
A
K
I
Y
G
G
K
A
I
--
Y
P
Q
I
K
A
L
-
K
--
N
-
A
N
I
V
V
G
T
P
G
R
I
L
D
-
H
I
-
N
R
G
T
--
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
----
N
M
-
G
-
F
I
K
D
V
E
K
I
L
N
A
----
C
----
N
---
K
D
K
R
I
L
L
---------
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
I
N
-----
A
N
I
E
Q
S
Y
V
E
V
-
N
E
N
E
R
-
F
-
E
---
A
L
C
-
R
-
L
-
L
--
K
N
K
E
----
F
-
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
----
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q------
N
-
P
-
E
S
------
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
Y
-
K
K
L
R
Y
I
E
R
-------------------
5
PsiBlast_PDB
74.65
30%
-121
- C4 -
4BRW
2
DHH1_YEAST
A:
[19-362]
----------------------
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
--
T
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
-----
E
K
V
K
-
P
K
------------------
L
---------
N
---------
K
-
I
Q
----
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
-
V
-
R
T
L
-
G
K
H
C
-
G
-
I
S
C
M
V
T
T
G
G
T
N
L
--
R
D
D
I
L
R
L
-
N
E
-
T
-
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
-
S
R
K
V
--
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
----
S
R
-
D
-
F
K
T
I
I
E
Q
I
L
S
F
----
L
----
P
---
P
T
H
Q
S
L
L
---------
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
-
L
T
L
K
G
-
I
T
Q
Y
Y
A
F
V
-
E
E
R
Q
K
-
L
-
H
---
C
L
N
-
T
-
L
F
S
--
K
L
Q
I
----
N
-
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
----
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K------
T
-
A
-
E
T
------
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
-
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
------------
30
PsiBlast_CBE
74.31
32%
-137
- C4 -
3EWS
1
DD19B_HUMAN
A:
[79-413]
---------------------
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
AE
P
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
-----
S
Q
V
E
-
P
A
------------------
N
---------
K
---------
Y
-
P
Q
----
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
-
I
E
Q
M
G
-
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
R
G
N
K
L
--
E
R
---
G
Q
-
K
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
F
--
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
----
A
T
-
Q
G
H
Q
D
Q
S
I
R
I
Q
R
M
----
L
----
P
---
R
N
C
Q
M
L
L
---------
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
-
E
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
S
R
D
E
-
K
------
F
Q
-
A
-
L
-
C
--
N
L
Y
G
A
ITI
A
-
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
----
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
-
K
-
D
G
NPD
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
---------------------------------
14
PsiBlast_PDB
74.22
30%
-107
- C4 -
4D25
4
?
A:
[56-404]
---------
N
-
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
--
S
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
-----
N
M
L
L
-
Q
D
------------------
P
---------
K
D
L
I
S
E
NG
C
A
Q
-
P
Q
----
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
-
A
-
R
K
F
-
S
Y
G
S
-
V
-
L
K
V
A
V
A
Y
G
G
T
A
V
--
R
H
Q
G
D
N
I
-
A
R
-
G
-
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
-
E
R
N
R
--
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
DMGF
M
P
-
S
-
I
E
K
M
M
L
H
P
T
M
V
----
E
----
T
---
T
K
R
Q
T
L
M
---------
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
-
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
-
T
K
Y
E
K
-
R
-
N
---
S
L
K
-
Q
-
L
I
E
--
E
N
D
G
----
K
-
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
----
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
-------
K
-
S
I
D
E
------
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
----------------------------------
15
PsiBlast_PDB
73.65
30%
-106
- C4 -
4D26
4
?
A:
[56-404]
---------
N
-
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
--
S
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
-----
N
M
L
L
-
Q
D
------------------
P
---------
K
D
L
I
S
E
NG
C
A
Q
-
P
Q
----
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
-
A
-
R
K
F
-
S
Y
G
S
-
V
-
L
K
V
A
V
A
Y
G
G
T
A
V
--
R
H
Q
G
D
N
I
-
A
R
-
G
-
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
-
E
R
N
R
--
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
DMGF
M
P
-
S
-
I
E
K
M
M
L
H
P
T
M
V
----
E
----
T
---
T
K
R
Q
T
L
M
---------
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
-
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
-
T
K
Y
E
K
-
R
-
N
---
S
L
K
-
Q
-
L
I
E
--
E
N
D
G
----
K
-
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
----
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
-------
K
-
S
I
D
E
------
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
----------------------------------
32
PsiBlast_CBE
73.61
32%
-127
- C4 -
3FHT
4
DD19B_HUMAN
A:
[42-376]
---------------------
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
AE
P
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
-----
S
Q
V
E
-
P
A
------------------
N
---------
K
---------
Y
-
P
Q
----
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
-
I
E
Q
M
G
-
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
R
G
N
K
L
--
E
R
---
G
Q
-
K
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
F
--
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
----
A
T
-
Q
G
H
Q
D
Q
S
I
R
I
Q
R
M
----
L
----
P
---
R
N
C
Q
M
L
L
---------
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
-
E
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
S
R
D
E
-
K
------
F
Q
-
A
-
L
-
C
--
N
L
Y
G
AITI
A
-
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
----
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V------
D
-
K
-
D
G
NPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
---------------------------------
19
PsiBlast_PDB
72.96
32%
-134
- C4 -
3RRM
1
DBP5_YEAST
A:
[22-353]
---------------------
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
-----
T
R
V
N
-
P
E
------------------
D
---------
A
---------
S
-
P
Q
----
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
-
V
-
Q
E
M
-
G
K
F
T
-
K
-
I
-
T
S
Q
L
I
----
V
--
P
D
S
F
E
K
N
-
K
Q
I
N
-
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
-
R
R
K
L
--
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-------
D
-
Q
Q
G
L
G
D
Q
C
I
R
V
----
K
----
R
F
LP
K
D
T
Q
L
V
L
---------
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
-----
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
K
-
F
-
D
---
V
L
T
-
E
-
L
-
Y
--
G
V
M
T
----
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
----
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQA
D
-
P
-
A
T
------
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
---------------------------------
20
PsiBlast_PDB
72.59
32%
-121
- C4 -
3RRN
2
DBP5_YEAST
A:
[22-353]
---------------------
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
-----
T
R
V
N
-
P
E
------------------
D
---------
A
---------
S
-
P
Q
----
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
-
V
-
Q
E
M
-
G
K
F
T
-
K
-
I
-
T
S
Q
L
I
----
V
--
P
D
S
F
E
K
N
-
K
Q
I
N
-
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
-
R
R
K
L
--
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-------
D
-
Q
Q
G
L
G
D
Q
C
I
R
V
----
K
----
R
F
LP
K
D
T
Q
L
V
L
---------
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-------
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
K
-
F
-
D
---
V
L
T
-
E
-
L
-
Y
--
G
V
M
T
----
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
----
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQA
D
-
P
-
A
T
------
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
---------------------------------
31
PsiBlast_CBE
72.54
32%
-127
- C4 -
3FHT
6
DD19B_HUMAN
B:
[42-376]
---------------------
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
AE
P
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
-----
S
Q
V
E
-
P
A
------------------
N
---------
K
---------
Y
-
P
Q
----
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
-
I
E
Q
M
G
-
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
R
G
N
------------
K
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
F
--
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
----
A
T
-
Q
G
H
Q
D
Q
S
I
R
I
Q
R
M
----
L
----
P
---
R
N
C
Q
M
L
L
---------
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
-
E
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
S
R
D
E
-
K
------
F
Q
-
A
-
L
-
C
--
N
L
Y
G
AITI
A
-
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
----
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V------
D
-
K
-
D
G
NPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
---------------------------------
29
PsiBlast_CBE
72.20
32%
-124
- C4 -
3G0H
4
DD19B_HUMAN
A:
[58-392]
---------------------
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
AE
P
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
-----
S
Q
V
E
-
P
A
------------------
N
---------
K
---------
Y
-
P
Q
----
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
-
I
E
Q
M
G
-
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
R
G
N
K
L
--
E
R
---
G
Q
-
K
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
F
--
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
----
A
T
-
Q
G
H
Q
D
Q
S
I
R
I
Q
R
M
----
L
----
P
---
R
N
C
Q
M
L
L
---------
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
-
E
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
-
S
S
R
D
E
-
K
------
F
Q
-
A
-
L
-
C
--
N
L
Y
G
AITI
A
-
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
----
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V------
D
-
K
-
D
G
NPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
---------------------------------
16
PsiBlast_PDB
71.43
33%
-110
- C4 -
5ELX
7
?
A:
[19-350]
---------------------
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
-----
T
R
V
N
-
P
E
------------------
D
---------
A
---------
S
-
P
Q
----
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
-
V
-
Q
E
M
-
G
K
F
T
-
K
-
I
-
T
S
Q
L
I
----
V
--
P
D
S
F
E
K
N
-
K
Q
I
N
-
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
-
R
R
K
L
--
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-------
D
-
Q
Q
G
L
G
D
Q
C
I
R
V
----
K
----
R
F
LP
K
D
T
Q
L
V
L
---------
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
-
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
K
-
F
-
D
---
V
L
T
-
E
-
L
-
Y
--
G
L
M
T
----
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
----
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQA
D
-
P
-
A
T
------
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
---------------------------------
18
PsiBlast_PDB
71.41
32%
-112
- C4 -
3PEW
9
DBP5_YEAST
A:
[22-353]
---------------------
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
-----
T
R
V
N
-
P
E
------------------
D
---------
A
---------
S
-
P
Q
----
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
-
V
-
Q
E
M
-
G
K
F
T
-
K
-
I
-
T
S
Q
L
I
----
V
--
P
D
S
F
E
K
N
-
K
Q
I
N
-
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
-
R
R
K
L
--
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-------
D
-
Q
Q
G
L
G
D
Q
C
I
R
V
----
K
----
R
F
LP
K
D
T
Q
L
V
L
---------
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
-
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
K
-
F
-
D
---
V
L
T
-
E
-
L
-
Y
--
G
V
M
T
----
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
----
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQA
D
-
P
-
A
T
------
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
---------------------------------
36
PsiBlast_CBE
71.14
32%
-126
- C4 -
4KBF
2
?
A:
[12-324]
---------------
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
-----
E
R
L
A
-
P
S
------------------
Q
ERG------
R
---------
K
-
P
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
-
L
-
T
---
A
V
A
P
-
H
-
L
K
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
L
-
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
Q
G
V
--
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
----
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
---
P
S
R
Q
T
L
L
---------
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--
I
-
K
D
E
P
V
T
Y
E
E
E
A
V
P
A
-
P
V
R
G
R
-
L
-
E
---
V
L
S
-
D
-
L
-
L
--
Y
V
A
S
----
P
D
R
A
M
V
F
T
R
T
K
A
E
----
T
E
E
I
A
Q
G
L
L
R
L
G
HP
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
-------
D
-
R
A
E
A
------
Y
Q
H
---------------------------------------------------
17
PsiBlast_PDB
70.75
33%
-109
- C4 -
3PEY
10
DBP5_YEAST
A:
[22-353]
---------------------
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
--
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
-----
T
R
V
N
-
P
E
------------------
D
---------
A
---------
S
-
P
Q
----
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
-
V
-
Q
E
M
-
G
K
F
T
-
K
-
I
-
T
S
Q
L
I
----
V
--
P
D
S
F
E
K
N
-
K
Q
I
N
-
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
-
R
R
K
L
--
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-------
D
-
Q
Q
G
L
G
D
Q
C
I
R
V
----
K
----
R
F
LP
K
D
T
Q
L
V
L
---------
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
-
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
K
-
F
-
D
---
V
L
T
-
E
-
L
-
Y
--
G
L
M
T
----
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
----
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQA
D
-
P
-
A
T
------
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
---------------------------------
63
PsiBlast_CBE
62.59
32%
-149
- C4 -
2OXC
1
DDX20_HUMAN
B:
[35-228]
---------------
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
-----
D
S
L
V
-
L
E
------------------
N
---------
L
---------
S
-
T
Q
----
I
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
-
I
-
T
A
I
-
G
I
K
M
-
E
G
L
E
C
H
V
F
I
G
G
T
P
L
--
S
Q
D
K
T
R
L
-
K
K
-
C
--
H
I
A
V
G
S
P
G
R
I
K
Q
-
L
I
-
E
L
D
Y
--
L
N
P
G
S
I
R
L
F
I
L
D
E
A
D
K
L
L
----
E
E
G
S
-
F
Q
E
Q
I
N
W
I
Y
S
S
----
L
----
P
---
A
S
K
Q
M
L
A
---------
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
61.98
32%
-145
- C4 -
2OXC
1
DDX20_HUMAN
A:
[35-228]
---------------
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
--
C
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
-----
D
S
L
V
-
L
E
------------------
N
---------
L
---------
S
-
T
Q
----
I
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
-
I
-
T
A
I
-
G
I
K
M
-
E
G
L
E
C
H
V
F
I
G
G
T
P
L
--
S
Q
D
K
T
R
L
-
K
K
-
C
--
H
I
A
V
G
S
P
G
R
I
K
Q
-
L
I
-
E
L
D
Y
--
L
N
P
G
S
I
R
L
F
I
L
D
E
A
D
K
L
L
----
E
E
G
S
-
F
Q
E
Q
I
N
W
I
Y
S
S
----
L
----
P
---
A
S
K
Q
M
L
A
---------
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
59.46
33%
-143
- C4 -
1T6N
1
DX39B_HUMAN
B:
[32-215]
----------------------
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
-----
Q
Q
L
E
-
P
V
------------------
T
---------
G
---------
Q
-
V
S
----
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
-
Y
-
E
R
F
S
K
Y
M
P
-
N
-
V
K
V
A
V
F
F
G
G
L
S
I
--
K
K
D
E
E
V
L
-
K
K
-
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
-
L
A
-
R
N
K
S
--
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
----
E
Q
L
D
-
M
R
R
D
V
Q
E
I
F
R
M
----
T
----
P
---
H
E
K
Q
V
M
M
---------
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
59.15
33%
-146
- C4 -
1T6N
1
DX39B_HUMAN
A:
[32-215]
----------------------
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
--
L
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
-----
Q
Q
L
E
-
P
V
------------------
T
---------
G
---------
Q
-
V
S
----
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
-
Y
-
E
R
F
S
K
Y
M
P
-
N
-
V
K
V
A
V
F
F
G
G
L
S
I
--
K
K
D
E
E
V
L
-
K
K
-
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
-
L
A
-
R
N
K
S
--
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
----
E
Q
L
D
-
M
R
R
D
V
Q
E
I
F
R
M
----
T
----
P
---
H
E
K
Q
V
M
M
---------
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
58.64
34%
-130
- C4 -
2GXQ
1
?
A:
[12-205]
---------------
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
-----
E
R
L
A
-
P
S
------------------
Q
ERG------
R
---------
K
-
P
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
-
L
-
T
---
A
V
A
P
-
H
-
L
K
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
L
-
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
Q
G
V
--
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
----
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
---
P
S
R
Q
T
L
L
---------
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
58.33
33%
-134
- C4 -
3MWL
2
?
B:
[12-205]
---------------
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
-----
E
R
L
A
-
P
S
------------------
Q
ERG------
R
---------
K
-
P
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
-
L
-
T
---
A
V
A
P
-
H
-
L
K
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
L
-
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
Q
G
V
--
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
----
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
---
P
S
R
Q
T
L
L
---------
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
58.13
34%
-132
- C4 -
2GXS
3
?
A:
[12-205]
---------------
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
-----
E
R
L
A
-
P
S
------------------
Q
ERG------
R
---------
K
-
P
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
-
L
-
T
---
A
V
A
P
-
H
-
L
K
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
L
-
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
Q
G
V
--
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
----
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
---
P
S
R
Q
T
L
L
---------
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
58.01
34%
-129
- C4 -
2GXS
4
?
B:
[12-205]
---------------
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
--
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
-----
E
R
L
A
-
P
S
------------------
Q
ERG------
R
---------
K
-
P
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
-
L
-
T
---
A
V
A
P
-
H
-
L
K
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
L
-
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
Q
G
V
--
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
----
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
---
P
S
R
Q
T
L
L
---------
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
57.37
33%
-129
- C4 -
3NBF
2
?
A:
[12-205]
---------------
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
-----
E
R
L
A
-
P
S
------------------
Q
ERG------
R
---------
K
-
P
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
-
L
-
T
---
A
V
A
P
-
H
-
L
K
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
L
-
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
Q
G
V
--
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
----
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
---
P
S
R
Q
T
L
L
---------
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
57.16
33%
-125
- C4 -
3NBF
2
?
B:
[12-205]
---------------
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
-----
E
R
L
A
-
P
S
------------------
Q
ERG------
R
---------
K
-
P
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
-
L
-
T
---
A
V
A
P
-
H
-
L
K
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
L
-
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
Q
G
V
--
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
----
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
---
P
S
R
Q
T
L
L
---------
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
56.75
33%
-124
- C4 -
3MWK
2
?
B:
[12-205]
---------------
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
-----
E
R
L
A
-
P
S
------------------
Q
ERG------
R
---------
K
-
P
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
-
L
-
T
---
A
V
A
P
-
H
-
L
K
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
L
-
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
Q
G
V
--
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
----
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
---
P
S
R
Q
T
L
L
---------
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
56.30
33%
-129
- C4 -
3NBF
4
?
C:
[12-205]
---------------
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
--
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
-----
E
R
L
A
-
P
S
------------------
Q
ERG------
R
---------
K
-
P
R
----
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
-
L
-
T
---
A
V
A
P
-
H
-
L
K
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
L
-
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
Q
G
V
--
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
----
S
M
-
G
-
F
E
E
E
V
E
A
L
L
S
A
----
T
----
P
---
P
S
R
Q
T
L
L
---------
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
55.14
33%
-129
- C4 -
3BER
4
DDX47_HUMAN
A:
[56-242]
-----------------
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
--
Q
G
--
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
-----
N
A
L
L
-
E
T
------------------
P
---------
Q
---------
R
-
L
F
----
A
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
-
F
-
E
A
L
-
G
S
S
I
-
G
-
V
Q
S
A
V
I
V
G
G
I
D
S
--
M
S
Q
S
L
A
L
-
A
K
-
K
-
P
H
I
I
I
A
T
P
G
R
L
I
D
H
L
E
-
N
T
K
G
--
F
N
L
R
A
L
K
Y
L
V
M
D
E
A
D
R
I
L
----
N
M
-
D
-
F
E
T
E
V
D
K
I
L
K
V
----
I
----
P
---
R
D
R
K
T
F
L
---------
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
54.92
32%
-136
- C4 -
3FMO
1
DD19B_HUMAN
B:
[109-299]
---------------------
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
AE
P
P
--
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
-----
S
Q
V
E
-
P
A
------------------
N
---------
K
---------
Y
-
P
Q
----
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
-
I
E
Q
M
G
-
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
R
G
N
K
L
--
E
R
G
-
Q
K
I
-
S
E
----
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
F
--
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
----
A
T
-
Q
G
H
Q
D
Q
S
I
R
I
Q
R
M
----
L
----
P
---
R
N
C
Q
M
L
L
---------
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
54.60
32%
-163
- C4 -
3IUY
1
DDX53_HUMAN
A:
[39-216]
-----------------------
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
--
Q
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
L
D----------------------------------------------
N
G
P
G
----
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
-
C
-
S
K
Y
-
S
Y
K
G
---
L
K
S
I
C
I
Y
G
--------
Q
I
E
D
I
-
S
K
-
G
-
V
D
I
I
I
A
T
P
G
R
L
N
D
-
L
Q
-
M
N
N
S
--
V
N
L
R
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
----
D
M
-
E
-
F
E
P
Q
I
R
K
I
L
L
D
----
V
----
R
---
P
D
R
Q
T
V
M
---------
T
S
A
T
W
----
P
D
T
V
R
Q
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
53.83
32%
-156
- C4 -
3IUY
2
DDX53_HUMAN
B:
[39-216]
-----------------------
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
--
Q
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
L
D
S---------------------------------------------
N
G
P
G
----
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
-
C
-
S
K
Y
-
S
Y
K
G
---
L
K
S
I
C
I
Y
G
-------------------
V
D
I
I
I
A
T
P
G
R
L
N
D
-
L
Q
-
M
N
N
S
--
V
N
L
R
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
----
D
M
-
E
-
F
E
P
Q
I
R
K
I
L
L
D
----
V
----
R
---
P
D
R
Q
T
V
M
---------
T
S
A
T
W
----
P
D
T
V
R
Q
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
53.18
32%
-143
- C4 -
2PL3
6
DDX10_HUMAN
A:
[49-232]
----------------------------
T
E
I
Q
K
Q
T
I
G
L
A
L
--
Q
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
-----
E
A
L
Y
-
R
L
------------------
Q
---------
W
---------
T
-
S
T
DGLG
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
-
L
-
R
K
V
-
G
K
N
H
-
D
-
F
S
A
G
L
I
I
G
G
--
L
--
K
H
E
A
E
R
I
--
N
-
N
-
I
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
-
E
T
V
S
--
F
H
A
T
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
----
D
M
-
G
-
F
A
D
T
M
N
A
V
I
E
N
----
L
----
P
---
K
K
R
Q
T
L
L
---------
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
W
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
50.24
34%
-128
- C4 -
3DKP
4
DDX52_HUMAN
A:
[42-225]
-----------------
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
V
M
L
--
H
G
--
R
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
I
L
-----
M
Q
L
K
Q
P
A
------------------
N
---------
K
---------
G
-
F
R
----
A
L
I
I
S
P
T
R
E
L
A
S
Q
I
H
R
E
-
L
-
I
K
I
-
S
E
G
T
-
G
-
F
R
-
I
H
M
I
H
K
A
A
V
A
A
K
K
F
G
P
K
S
-
S
K
-
K
-
F
D
I
L
V
T
T
P
N
R
L
I
Y
-
L
L
-
K
Q
D
P
PG
I
D
L
A
S
V
E
W
L
V
V
D
E
S
D
K
L
F
-----------
E
D
G
--
G
F
R
D
----
Q
----
L
---
A
S
I
F
L
A
C
TSHK
V
R
R
A
M
F
S
A
T
F
A
Y
D
V
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------