@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu07490: (2016-06-11 )
MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKSTILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGRHPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDLLLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKIYNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK
Atome Classification :
(31 SA)
.........10..-..-..--..20........30........40........50.....----.---..60....--..--.--.70---.......----..80........-90........----100.----......110--..--------...-------..120.......130-..-.....----.--------140.......150....------...160.......170.......180.......190.......200.......210...-....220.....---..230......---------.240.---......250.......260....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGKLAA
D
Q
L
T
LSY-D
S
-
T
V
--
I
I
DG
V
D
L
K
I
EE
G
K
I
T
A
L
I
GANGC
G
K
S
T
I
L
K
S
L
A
R
LMAPK----S---
G
T
V
L
LEGK--DI--H--RQ----
P
S
K
E
V
A
K
----
K
L
AILPQSPQAP-EGL
T
V
E
E
L
C
Y
----FGRH----
P
H
K
K
L
L
S
K
H--TQ--------
E
D
H
-------
D
M
V
E
W
A
L
EAT
G
M
I
-
E
-LK-DR
T
L
D
----
A
--------LSGGQR
Q
R
A
W
I
S
M
A
LAQ------G
T
D
L
L
L
LDEPT
T
Y
L
D
I
S
H
Q
I
E
V
L
E
L
L
K
K
L
N
RDHG
R
T
V
V
M
V
L
H
D
L
N
Q
A
A
Q
Y
A
D
Y
L
I
S
V
LD-GKIYNAGT
P
E
D
V---FT
Q
P
F
F
R
E
V
FG---------
L
E
C
C
I
---MRSPIDQKPMCLPTGLCPKLRAK
30
PsiBlast_CBE
84.17
31%
0
- C- -
4FWI
3
?
B:
[25-269]
-----------------------
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
N
GRIL
S
---
G
R
V
L
Y
K
G
K
--
D
L
--
L
--
T
M
----
R
E
E
E
L
R
K
IRWK
E
I
A
L
V
P
Q
A
A
Q
Q
S
-
L
N
P
T
M
K
V
I
E
H
----
F
--------------
K
D
--
T
V
--------
E
A
H
GVRWSHS
E
L
I
E
K
A
S
E
K
L
R
M
V
-
R
-
L
N
P
E
A
V
L
N
----
S
YPLQ----
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
------
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
-
G
N
L
V
E
Y
N
S
T
F
Q
I
---
F
K
N
P
L
H
P
Y
T
R
G
---------
L
I
N
S
I
---
M
----------------------
21
PsiBlast_CBE
75.48
32%
-145
- C1 -
4G1U
1
HMUV_YERPE
D:
[12-260]
---
L
E
A
S
H
L
H
Y
H
V
-
Q
Q
-
Q
A
--
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
----
H
---
G
E
C
H
L
L
G
Q
--
N
L
--
N
--
S
W
----
Q
P
K
A
L
A
R
----
T
R
A
V
M
R
Q
Y
S
E
L
A
-
F
P
F
S
V
S
E
V
I
Q
----
M
G
R
A
----
P
Y
G
G
--------
S
--------
Q
D
R
-------
Q
A
L
Q
Q
V
M
A
Q
T
D
C
L
-
A
-
L
A
-
Q
R
D
Y
R
----
V
--------
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
LWQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
-
G
K
L
V
A
C
G
T
P
E
E
V
---
L
N
A
E
T
L
T
Q
W
Y
Q
---------
A
D
L
G
V
---
S
R
H
P
E
S
A
L
P
--------------
1
PsiBlast_PDB
74.34
32%
-144
- C1 -
4G1U
1
HMUV_YERPE
C:
[12-260]
---
L
E
A
S
H
L
H
Y
H
V
-
Q
Q
-
Q
A
--
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
----
H
---
G
E
C
H
L
L
G
Q
--
N
L
--
N
--
S
W
----
Q
P
K
A
L
A
R
----
T
R
A
V
M
R
Q
Y
S
E
L
A
-
F
P
F
S
V
S
E
V
I
Q
----
M
G
R
A
----
P
Y
G
G
--------
S
--------
Q
D
R
-------
Q
A
L
Q
Q
V
M
A
Q
T
D
C
L
-
A
-
L
A
-
Q
R
D
Y
R
----
V
--------
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
-
G
K
L
V
A
C
G
T
P
E
E
V
---
L
N
A
E
T
L
T
Q
W
Y
Q
---------
A
D
L
G
V
---
S
R
H
P
E
S
A
L
P
--------------
25
PsiBlast_CBE
71.05
31%
-137
- C1 -
1VPL
2
?
A:
[14-246]
-
G
A
V
V
V
K
D
L
R
K
R
I
-
G
K
-
K
E
--
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
----
S
---
G
I
V
T
V
F
G
K
--
N
V
--
V
--
E
E
----
P
H
-
E
V
R
K
----
L
I
S
Y
L
P
E
E
A
G
A
Y
-
R
N
M
Q
G
I
E
Y
L
R
----
F
--------
V
A
G
F
Y
A
S
S
--
S
S
--------
E
I
E
-------
E
M
V
E
R
A
T
E
I
A
G
L
G
-
E
K
I
K
-
D
R
-
V
S
----
T
--------
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
------
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
Q
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
-
G
T
I
V
E
T
G
T
V
E
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
F
-----------------------------------------
4
PsiBlast_PDB
66.76
33%
-132
- C1 -
4YMT
-
?
J:
[10-224]
-----------
N
F
-
G
S
-
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----
K
---
G
E
V
F
I
D
G
V
--
K
I
--
N
NG
K
V
----
N
I
N
K
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
-
P
H
L
T
A
I
E
N
I
T
----
L
A
P
V
----
K
V
K
K
M
N
K
K
E
--
A
E
--------
E
----------
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
---
F
--------------------------------------------------
3
PsiBlast_PDB
64.70
33%
-134
- C1 -
4YMS
-
?
J:
[10-224]
-----------
N
F
-
G
S
-
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----
K
---
G
E
V
F
I
D
G
V
--
K
I
--
N
NG
K
V
----
N
I
N
K
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
-
P
H
L
T
A
I
E
N
I
T
----
L
A
P
V
----
K
V
K
K
M
N
K
K
E
--
A
E
--------
E
----------
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
---
F
--------------------------------------------------
7
PsiBlast_PDB
64.07
33%
-136
- C1 -
4YMW
-
?
J:
[10-224]
-----------
N
F
-
G
S
-
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----
K
---
G
E
V
F
I
D
G
V
--
K
I
--
N
NG
K
V
----
N
I
N
K
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
-
P
H
L
T
A
I
E
N
I
T
----
L
A
P
V
----
K
V
K
K
M
N
K
K
E
--
A
E
--------
E
----------
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
---
F
--------------------------------------------------
8
PsiBlast_PDB
63.87
29%
-129
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[8-234]
---
L
K
V
E
E
L
N
Y
N
Y
S
D
G
-
T
H
--
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
----
S
---
G
R
I
L
F
D
N
K
PI
D
Y
--
S
--
R
K
----
G
I
M
K
L
R
E
----
S
I
G
I
V
F
Q
D
P
D
N
Q
L
F
S
A
S
V
Y
Q
D
V
S
----
F
G
A
V
----
N
M
K
L
----
P
--
E
D
--------
E
I
R
-------
K
R
V
D
N
A
L
K
R
T
G
I
E
-
H
-
L
K
-
D
K
P
T
H
----
C
--------
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
------
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
-
G
R
V
I
L
Q
G
N
P
K
E
V
---
F
A
E
------------------------------------------------
18
PsiBlast_PDB
63.35
29%
-129
- C1 -
1Q1E
-
MALK_ECOLI
A:
[4-259]
---
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
--
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
----
S
---
G
D
L
F
I
G
E
K
--
R
M
--
N
--
D
T
----
P
P
A
E
--
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
-
P
H
L
S
V
A
E
N
M
S
----
F
G
L
--------
K
L
A
G
A
K
--
K
E
--------
V
I
N
-------
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
----
A
--------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-
G
R
V
A
Q
V
G
K
P
L
E
L
---
Y
H
Y
P
A
D
R
F
V
A
G
F
I
GSP
K
M
N
F
L
P
V
K
V
---
T
A
T
A
I
D
Q
V
Q
V
E
L
P
----------
23
PsiBlast_CBE
63.06
33%
-136
- C1 -
4YMU
2
?
A:
[10-224]
-----------
N
F
-
G
S
-
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----
K
---
G
E
V
F
I
D
G
V
--
K
I
--
N
NG
K
V
----
N
I
N
K
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
-
P
H
L
T
A
I
E
N
I
T
----
L
A
P
V
----
K
V
K
K
M
N
K
K
E
--
A
E
--------
E
----------
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
---
F
--------------------------------------------------
5
PsiBlast_PDB
63.01
33%
-130
- C1 -
4YMU
2
?
J:
[10-224]
-----------
N
F
-
G
S
-
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----
K
---
G
E
V
F
I
D
G
V
--
K
I
--
N
NG
K
V
----
N
I
N
K
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
-
P
H
L
T
A
I
E
N
I
T
----
L
A
P
V
----
K
V
K
K
M
N
K
K
E
--
A
E
--------
E
----------
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
---
F
--------------------------------------------------
22
PsiBlast_CBE
62.31
33%
-130
- C1 -
4YMV
1
?
A:
[10-224]
-----------
N
F
-
G
S
-
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----
K
---
G
E
V
F
I
D
G
V
--
K
I
--
N
NG
K
V
----
N
I
N
K
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
-
P
H
L
T
A
I
E
N
I
T
----
L
A
P
V
----
K
V
K
K
M
N
K
K
E
--
A
E
--------
E
----------
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
---
F
--------------------------------------------------
9
PsiBlast_PDB
62.00
29%
-170
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[5-227]
---
L
S
V
E
N
L
G
F
Y
Y
-
Q
A
E
N
F
--
L
F
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
R
P
I
----
Q
---
G
K
I
-----------------------
E
V
Y
Q
----
S
I
G
F
V
P
Q
F
F
S
S
P
-
F
A
Y
S
V
L
D
I
V
L
----
M
G
R
S
----
T
H
I
N
T
F
A
K
P
--
K
S
--------
H
D
Y
-------
Q
V
A
M
Q
A
L
D
Y
L
N
L
T
-
H
-
L
A
-
K
R
E
F
T
----
S
--------
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
------
E
C
K
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
A
Q
S
Q
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
L
-
L
L
N
-
K
Q
N
F
K
F
G
E
T
R
N
I
---
L
T
S
E
N
L
T
A
L
F
H
---------
L
------------------------------
6
PsiBlast_PDB
60.40
33%
-131
- C1 -
4YMV
1
?
J:
[10-224]
-----------
N
F
-
G
S
-
L
E
--
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
----
K
---
G
E
V
F
I
D
G
V
--
K
I
--
N
NG
K
V
----
N
I
N
K
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
-
P
H
L
T
A
I
E
N
I
T
----
L
A
P
V
----
K
V
K
K
M
N
K
K
E
--
A
E
--------
E
----------
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
----
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
---
F
--------------------------------------------------
67
HHSearch
58.91
29%
-129
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-225]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
--
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
----
S
---
G
D
L
F
I
G
E
K
--
R
M
--
N
--
D
T
----
P
--
P
A
E
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
-
P
H
L
S
V
A
E
N
M
S
----
F
G
L
K
----
L
A
G
A
----
K
--
K
E
--------
V
I
N
-------
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
----
A
--------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-
G
R
V
A
Q
V
G
K
P
L
E
L
---
Y
H
Y
P
-----------------------------------------------
14
PsiBlast_PDB
58.23
29%
-112
- C1 -
5D3M
1
?
A:
[24-280]
---
I
S
F
D
H
V
T
F
T
Y
-
P
D
-
S
P
RP
A
L
S
D
L
S
F
A
I
E
R
G
S
W
T
A
L
I
G
H
N
G
S
G
K
S
T
V
S
K
L
I
N
G
L
L
A
P
D
----
D
LDK
S
S
I
T
V
D
G
V
--
K
L
--
G
--
A
D
----
T
V
W
E
V
R
E
----
K
V
G
I
V
F
Q
N
P
D
N
Q
F
V
G
A
T
V
S
D
D
V
A
----
F
G
L
E
N
R
AV
P
R
P
E
M
L
K
-------------------------
I
V
A
Q
A
V
A
D
V
G
M
A
-
D
-
Y
A
-
D
S
E
P
S
----
N
--------
L
S
G
G
Q
K
Q
R
V
A
I
A
G
I
L
A
V
------
K
P
Q
V
I
I
L
D
E
S
T
S
M
L
D
P
E
G
K
E
Q
I
L
D
L
V
R
K
I
K
E
D
N
N
L
T
V
I
S
I
T
H
D
L
E
E
A
A
G
-
A
D
Q
V
L
V
L
D
D
-
G
Q
L
L
D
Q
G
K
P
E
E
I
---
F
P
K
V
E
M
L
K
R
I
G
---------
L
D
I
P
F
V
Y
R
L
K
Q
L
L
K
E
R
G
I
V
L
P
----------
16
PsiBlast_PDB
57.79
29%
-127
- C1 -
1Q1B
-
MALK_ECOLI
A:
[4-259]
---
V
Q
L
Q
N
V
T
K
A
W
-
G
E
-
V
V
--
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
----
S
---
G
D
L
F
I
G
E
K
--
R
M
--
N
--
D
T
----
P
P
A
E
--
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
-
P
H
L
S
V
A
E
N
M
S
----
F
G
--------
L
K
L
A
G
A
K
--
K
E
--------
V
I
N
-------
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
----
A
--------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
-
G
R
V
A
Q
V
G
K
P
L
E
L
---
Y
H
Y
P
A
D
R
F
V
A
G
F
IGSP
K
M
N
F
L
P
V
K
V
---
T
A
T
A
I
D
Q
V
Q
V
E
L
P
----------
42
PsiBlast_CBE
57.27
31%
-107
- C1 -
1B0U
4
HISP_SALTY
A:
[5-244]
-
N
K
L
H
V
I
D
L
H
K
R
Y
-
G
G
-
H
E
--
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
----
E
---
G
A
I
I
V
N
G
Q
--
N
I
--
N
--
L
V
----
R
D
K
D
G
Q
L
----
K
V
A
D
K
N
Q
L
R
L
L
R
-
T
R
L
T
M
-
V
F
Q
H
----
F
N
L
W
----
S
H
M
T
V
L
E
N
V
--
M
E
APIQVLGL
S
K
H
-------
D
A
R
E
R
A
L
K
Y
L
A
K
V
-
G
-
I
D
-
E
R
A
Q
G
----
K
YPVH----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
------
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
---
F
G
N
P
-----------------------------------------------
26
PsiBlast_CBE
57.01
31%
-127
- C1 -
4MKI
4
ECFA2_CALS4
B:
[23-249]
---------------
A
-
T
V
--
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
----
K
---
G
K
I
Y
I
N
G
I
--
D
I
TD
K
--
K
V
----
S
L
K
D
I
R
K
----
Q
V
G
L
V
F
Q
---
Y
P
-
E
Y
Q
L
F
E
E
T
V
F
K
D
I
A
F
G
------
P
S
N
L
G
L
S
E
----
E
--------
E
V
K
-------
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
-
L
A
-
D
K
S
P
F
----
E
--------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
------
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
-
G
K
I
E
L
I
G
T
P
R
E
V
---
F
R
E
A
E
R
L
E
K
I
G
---------
L
S
V
----------------------------
63
HHSearch
56.89
34%
-116
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[2-234]
T
A
A
L
H
I
G
H
L
S
K
S
F
-
Q
N
-
T
P
--
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
----
S
---
G
E
I
S
L
S
G
K
--
T
I
--
F
--
S
K
N
T
--
N
L
P
V
R
E
R
----
R
L
G
Y
L
V
Q
E
G
V
L
F
-
P
H
L
T
V
Y
R
N
I
A
----
Y
G
L
G
----
N
G
K
G
----
R
--
T
A
--------
Q
E
R
-------
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
-
L
A
-
G
R
Y
P
H
----
E
--------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
------
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
---
Y
R
Q
------------------------------------------------
24
PsiBlast_CBE
52.15
34%
-114
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[9-230]
-------
H
L
S
K
S
F
-
Q
N
-
T
P
--
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
----
S
---
G
E
I
S
L
S
G
K
--
T
I
--
F
--
S
K
NTNL
P
V
R
E
--
R
----
R
L
G
Y
L
V
Q
E
G
V
L
F
-
P
H
L
T
V
Y
R
N
I
A
----
Y
G
L
G
----
N
G
K
G
----
R
--
T
A
--------
Q
E
R
-------
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
-
L
A
-
G
R
Y
P
H
----
E
--------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
------
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
---
Y
R
Q
P
-----------------------------------------------
38
PsiBlast_CBE
49.60
31%
-124
- C1 -
1L2T
4
Y796_METJA
B:
[21-223]
----------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
----
E
---
G
E
V
Y
I
D
N
I
--
K
T
--
N
--
D
L
----
D
D
D
E
L
T
K
IRRD
K
I
G
F
V
F
Q
Q
F
N
L
I
-
P
L
L
T
A
L
E
----------
N
----
V
E
L
P
L
I
F
K
Y
RG
A
M
--------
S
G
E
-------
E
R
R
K
R
A
L
E
C
L
K
M
A
-
E
-
L
E
-
E
R
F
A
N
HKPN
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
---------------------------------------------------------------
15
PsiBlast_PDB
49.51
34%
-115
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[9-235]
-------
H
L
S
K
S
F
-
Q
N
-
T
P
--
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
----
S
---
G
E
I
S
L
S
G
K
--
T
I
--
F
--
S
K
N
T
N
L
P
V
R
E
--
R
----
R
L
G
Y
L
V
Q
E
G
V
L
F
-
P
H
L
T
V
Y
R
N
I
A
----
Y
G
L
G
----
N
G
K
G
----
R
--
T
A
--------
Q
E
R
-------
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
-
L
A
-
G
R
Y
P
H
----
E
--------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
------
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
---
Y
R
Q
P
-----------------------------------------------
41
PsiBlast_CBE
48.70
31%
-117
- C1 -
3TIF
7
Y796_METJA
A:
[21-223]
----------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
----
E
---
G
E
V
Y
I
D
N
I
--
K
T
--
N
--
D
L
----
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
-
P
L
L
T
A
L
E
----------
N
----
V
E
L
P
L
I
F
K
Y
R
G
A
M
--------
S
G
E
-------
E
R
R
K
R
A
L
E
C
L
K
M
A
-
E
-
L
E
-
E
R
F
A
N
HKPN
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
---------------------------------------------------------------
40
PsiBlast_CBE
47.49
31%
-127
- C1 -
3TIF
6
Y796_METJA
B:
[21-223]
----------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
----
E
---
G
E
V
Y
I
D
N
I
--
K
T
--
N
--
D
L
----
D
D
D
E
L
T
K
IRRD
K
I
G
F
V
F
Q
Q
F
N
L
I
-
P
L
L
T
A
L
E
----------
N
----
V
E
L
P
L
I
F
K
Y
RG
A
M
--------
S
G
E
-------
E
R
R
K
R
A
L
E
C
L
K
M
A
-
E
-
L
E
-
E
R
F
A
N
HKPN
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
---------------------------------------------------------------
34
PsiBlast_CBE
45.87
33%
-115
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[390-598]
---------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
----
S
---
G
T
I
S
L
D
G
H
--
D
I
--
R
--
Q
L
----
N
P
V
W
L
R
S
----
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
----
G
A
D
D
----
P
-----
S
S
V
--
T
A
--------
E
E
I
-------
Q
R
V
A
E
V
A
N
A
V
A
F
I
-
R
-
N
F
-
P
Q
G
F
N
----
T
V
V
G
EKG
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
------
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
--
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------------------------------------------
39
PsiBlast_CBE
45.37
31%
-115
- C1 -
1L2T
4
Y796_METJA
A:
[21-223]
----------------------
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
----
E
---
G
E
V
Y
I
D
N
I
--
K
T
--
N
--
D
L
----
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
-
P
L
L
T
A
L
E
----------
N
----
V
E
L
P
L
I
F
K
Y
R
G
A
M
--------
S
G
E
-------
E
R
R
K
R
A
L
E
C
L
K
M
A
-
E
-
L
E
-
E
R
F
A
N
HKPN
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
---------------------------------------------------------------
31
PsiBlast_CBE
44.51
33%
-120
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[359-572]
---------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
----
S
---
G
T
I
S
L
D
G
H
--
D
I
--
R
--
Q
L
----
N
P
V
W
L
R
S
----
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
----
G
A
D
D
----
P
-----
S
S
V
--
T
A
--------
E
E
I
-------
Q
R
V
A
E
V
A
N
A
V
A
F
I
-
R
-
N
F
-
P
Q
G
F
N
----
T
V
V
G
EK
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
------
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
--
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
---
L
S
K
P
-----------------------------------------------
32
PsiBlast_CBE
42.46
33%
-113
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[359-567]
---------------------
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
----
S
---
G
T
I
S
L
D
G
H
--
D
I
--
R
--
Q
L
----
N
P
V
W
L
R
S
----
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
----
G
A
D
D
----
P
-----
S
S
V
--
T
A
--------
E
E
I
-------
Q
R
V
A
E
V
A
N
A
V
A
F
I
-
R
-
N
F
-
P
Q
G
F
N
----
T
VVGEKG
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
------
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
--
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------------------------------------------
48
PsiBlast_CBE
29.45
31%
-125
- C1 -
3BK7
1
?
A:
[378-548]
----------------------------
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
----
E
---
G
K
V
-----------------------
E
W
D
L
----
T
V
A
Y
K
P
Q
Y
I
K
A
E
-
Y
E
G
T
V
Y
E
L
------
L
S
K
I
----
D
S
S
K
L
N
S
N
F
--
Y
K
--------
T
E
-------------
L
L
K
P
L
G
I
I
-
D
-
L
Y
-
D
R
N
V
E
----
D
--------
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
------
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
-
V
F
E
-
G
E
----------------------------------------------------------------
47
PsiBlast_CBE
18.07
31%
-124
- C1 -
3J15
1
?
B:
[364-534]
----------------------------
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
----
E
---
G
K
V
-----------------------
E
W
D
L
----
T
V
A
Y
K
P
Q
Y
I
K
A
E
-
Y
E
G
T
V
Y
E
L
L
---------------
S
K
I
D
S
S
K
--
L
N
--------
S
N
F
-------
Y
K
T
E
L
-
L
K
P
L
G
I
I
-
D
-
L
Y
-
D
R
N
V
E
----
D
--------
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
------
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
-
V
F
E
-
G
E
----------------------------------------------------------------